CA2423481C - Isolated peptides which bind to hla-c molecules and uses thereof - Google Patents

Isolated peptides which bind to hla-c molecules and uses thereof Download PDF

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Publication number
CA2423481C
CA2423481C CA002423481A CA2423481A CA2423481C CA 2423481 C CA2423481 C CA 2423481C CA 002423481 A CA002423481 A CA 002423481A CA 2423481 A CA2423481 A CA 2423481A CA 2423481 C CA2423481 C CA 2423481C
Authority
CA
Canada
Prior art keywords
hla
cells
cell
peptide
eso
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002423481A
Other languages
English (en)
French (fr)
Other versions
CA2423481A1 (en
Inventor
Sacha Gnjatic
Lloyd J. Old
Yasuhiro Nagata
Elke Jager
Yao-Tseng Chen
Alexander Knuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ludwig Cancer Research
Cornell Research Foundation Inc
Memorial Sloan Kettering Cancer Center
Original Assignee
Ludwig Cancer Research
Cornell Research Foundation Inc
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Cancer Research, Cornell Research Foundation Inc, Memorial Sloan Kettering Cancer Center filed Critical Ludwig Cancer Research
Publication of CA2423481A1 publication Critical patent/CA2423481A1/en
Application granted granted Critical
Publication of CA2423481C publication Critical patent/CA2423481C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4269—NY-ESO
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002423481A 2000-09-26 2001-09-24 Isolated peptides which bind to hla-c molecules and uses thereof Expired - Fee Related CA2423481C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/670,456 2000-09-26
US09/670,456 US6506875B1 (en) 2000-09-26 2000-09-26 Isolated peptides which bind to HLA-C molecules and uses thereof
PCT/US2001/029920 WO2002026778A2 (en) 2000-09-26 2001-09-24 Isolated peptides which bind to hla-c molecules and uses thereof

Publications (2)

Publication Number Publication Date
CA2423481A1 CA2423481A1 (en) 2002-04-04
CA2423481C true CA2423481C (en) 2008-06-10

Family

ID=24690468

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002423481A Expired - Fee Related CA2423481C (en) 2000-09-26 2001-09-24 Isolated peptides which bind to hla-c molecules and uses thereof

Country Status (9)

Country Link
US (2) US6506875B1 (enExample)
EP (1) EP1320609B1 (enExample)
JP (1) JP4174570B2 (enExample)
CN (1) CN1253572C (enExample)
AT (1) ATE325876T1 (enExample)
AU (2) AU9305101A (enExample)
CA (1) CA2423481C (enExample)
DE (1) DE60119552T2 (enExample)
WO (1) WO2002026778A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7888100B2 (en) * 1996-10-03 2011-02-15 Memorial Sloan-Kettering Cancer Research Isolated nucleic acid molecules which encode immunogenic portions of NY-ESO-1 protein
CN105555756B (zh) 2013-06-28 2018-12-07 奥克兰联合服务有限公司 氨基酸缀合物和肽缀合物及缀合方法
CN105085615A (zh) * 2014-05-23 2015-11-25 上海市普陀区中心医院 一种多肽序列及其应用
CN105085616A (zh) * 2014-05-23 2015-11-25 上海市普陀区中心医院 一种氨基酸序列及其应用
CA2971677A1 (en) 2014-12-23 2016-06-30 Margaret Anne Brimble Amino acid and peptide conjugates and uses thereof
TW201735952A (zh) 2016-02-26 2017-10-16 瑪格蕾特 安 布萊博 胺基酸及肽共軛物以及共軛過程
MX2021010537A (es) 2019-03-04 2021-12-10 Univ Health Network Receptores de linfocitos t y metodos de uso de estos.
AU2020231927A1 (en) 2019-03-04 2021-09-30 University Health Network T cell receptors and methods of use thereof
US12522644B2 (en) 2019-03-04 2026-01-13 University Health Network T cell receptors and methods of use thereof
EP3935173A4 (en) * 2019-03-04 2023-05-31 University Health Network T-CELL RECEPTORS AND METHODS OF USE THEREOF
CA3133945A1 (en) 2019-03-25 2020-10-01 University Health Network T cell receptors and methods of use thereof
CN120397921B (zh) * 2025-05-28 2025-12-02 江苏新恒鼎装备制造有限公司 一种具有自锁功能的船用曲轴红套升降平台

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013481A (en) * 1993-07-22 2000-01-11 Ludwig Institute For Cancer Research Isolated, nucleic acid molecules which code for gage tumor rejection antigen, the tumor rejection antigen, and uses thereof
US6251603B1 (en) * 1996-10-03 2001-06-26 Ludwig Institute For Cancer Research Method for determining status of a cancerous condition by determining antibodies to NY-ESO-1 in a patient sample
DE69837273T2 (de) * 1997-10-08 2008-01-31 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Menschliches krebsantigen ny eso-1/cag-3 und dazu kodierendes gen
WO1999037665A1 (en) * 1998-01-23 1999-07-29 Ludwig Institute For Cancer Research Isolated, polypeptides which bind to hla-a29 molecules, nucleic acid, the molecules encoding these, and uses thereof
AU5992999A (en) * 1998-10-02 2000-04-26 Ludwig Institute For Cancer Research Tumor antigens and ctl clones isolated by a novel procedure
WO2001062917A1 (en) * 2000-02-22 2001-08-30 Ludwig Institute For Cancer Research Isolated genomic sequences which encode the ny-eso-1 cancer testis tumor antigen and uses thereof

Also Published As

Publication number Publication date
US6506875B1 (en) 2003-01-14
EP1320609A2 (en) 2003-06-25
CA2423481A1 (en) 2002-04-04
WO2002026778A2 (en) 2002-04-04
EP1320609B1 (en) 2006-05-10
WO2002026778A3 (en) 2003-02-13
US20030050451A1 (en) 2003-03-13
JP2004524271A (ja) 2004-08-12
ATE325876T1 (de) 2006-06-15
DE60119552D1 (de) 2006-06-14
AU2001293051B2 (en) 2007-04-26
AU9305101A (en) 2002-04-08
DE60119552T2 (de) 2007-04-19
HK1060594A1 (en) 2004-08-13
JP4174570B2 (ja) 2008-11-05
US7009035B2 (en) 2006-03-07
CN1253572C (zh) 2006-04-26
CN1476480A (zh) 2004-02-18

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Effective date: 20170925