CA2422902A1 - Modified factor viii - Google Patents
Modified factor viii Download PDFInfo
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- CA2422902A1 CA2422902A1 CA002422902A CA2422902A CA2422902A1 CA 2422902 A1 CA2422902 A1 CA 2422902A1 CA 002422902 A CA002422902 A CA 002422902A CA 2422902 A CA2422902 A CA 2422902A CA 2422902 A1 CA2422902 A1 CA 2422902A1
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- factor viii
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/10—Factor VIII, AHF; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
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| US23404700P | 2000-09-19 | 2000-09-19 | |
| US60/234,047 | 2000-09-19 | ||
| US23646000P | 2000-09-29 | 2000-09-29 | |
| US60/236,460 | 2000-09-29 | ||
| PCT/US2001/029431 WO2002024723A1 (en) | 2000-09-19 | 2001-09-19 | Modified factor viii |
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| CA2422902A1 true CA2422902A1 (en) | 2002-03-28 |
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| CA002422902A Abandoned CA2422902A1 (en) | 2000-09-19 | 2001-09-19 | Modified factor viii |
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| EP (1) | EP1319016A4 (enExample) |
| JP (1) | JP2004525608A (enExample) |
| KR (1) | KR100638184B1 (enExample) |
| CN (1) | CN1205221C (enExample) |
| AU (1) | AU2001292861A1 (enExample) |
| CA (1) | CA2422902A1 (enExample) |
| HU (1) | HUP0301179A3 (enExample) |
| MX (1) | MXPA03002256A (enExample) |
| PL (1) | PL206105B1 (enExample) |
| RU (1) | RU2003107100A (enExample) |
| WO (1) | WO2002024723A1 (enExample) |
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| US7560107B2 (en) | 1996-06-26 | 2009-07-14 | Emory University | Modified factor VIII |
| US6458563B1 (en) * | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
| MXPA04005079A (es) * | 2001-11-30 | 2004-08-19 | Univ Emory | Variantes del dominio c2 del factor viii. |
| US7485291B2 (en) | 2003-06-03 | 2009-02-03 | Cell Genesys, Inc. | Compositions and methods for generating multiple polypeptides from a single vector using a virus derived peptide cleavage site, and uses thereof |
| US7709224B2 (en) | 2003-06-03 | 2010-05-04 | Biosante Pharmaceuticals, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
| US20050123997A1 (en) * | 2003-10-30 | 2005-06-09 | Lollar John S. | Modified fVIII having reduced immunogenicity through mutagenesis of A2 and C2 epitopes |
| US7855274B2 (en) * | 2003-12-03 | 2010-12-21 | University Of Rochester | Recombinant factor VIII having increased specific activity |
| EP1750733B1 (en) * | 2004-05-03 | 2013-12-11 | Emory University | METHOD OF ADMINISTERING PORCINE B-DOMAINLESS fVIII |
| SI1824988T1 (sl) | 2004-11-12 | 2017-11-30 | Bayer Healthcare Llc | Usmerjena modifikacija FVIII |
| WO2006063031A2 (en) | 2004-12-06 | 2006-06-15 | Haplomics | Allelic variants of human factor viii |
| FR2913020B1 (fr) * | 2007-02-23 | 2012-11-23 | Biomethodes | Nouveaux facteurs viii pour le traitement des hemophiles de type a |
| CA2703948A1 (en) * | 2007-11-01 | 2009-05-07 | University Of Rochester | Recombinant factor viii having increased stability |
| CN104059155A (zh) * | 2008-05-16 | 2014-09-24 | 拜耳医药保健有限公司 | 靶向性凝固因子及其使用方法 |
| BR112012004094A2 (pt) | 2009-08-24 | 2016-03-08 | Amunix Operating Inc | composições de fator vii de coagulação e métodos para fazer e usar as mesmas |
| EP2498804A4 (en) * | 2009-11-13 | 2013-05-08 | Puget Sound Blood Ct | FACTOR VIII B CELL EPITOPARIANTS WITH REDUCED IMMUNOGENITY |
| US20110177107A1 (en) * | 2010-01-14 | 2011-07-21 | Haplomics, Inc. | Predicting and reducing alloimmunogenicity of protein therapeutics |
| US9150637B2 (en) | 2010-11-05 | 2015-10-06 | Baxalta Inc. | Variant of antihemophilic factor VIII having increased specific activity |
| HRP20221531T1 (hr) | 2012-02-15 | 2023-02-17 | Bioverativ Therapeutics Inc. | Pripravci faktora viii i postupci dobivanja i korištenja istih |
| LT2822577T (lt) | 2012-02-15 | 2019-03-25 | Bioverativ Therapeutics Inc. | Rekombinantiniai faktoriaus viii baltymai |
| US10272163B2 (en) | 2012-12-07 | 2019-04-30 | The Regents Of The University Of California | Factor VIII mutation repair and tolerance induction |
| US10093901B2 (en) | 2013-05-10 | 2018-10-09 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Use of specific regulatory T-cells to induce immune tolerance |
| WO2014209942A1 (en) | 2013-06-24 | 2014-12-31 | Weidong Xiao | Mutant factor viii compositions and methods |
| EP3033097B1 (en) | 2013-08-14 | 2021-03-10 | Bioverativ Therapeutics Inc. | Factor viii-xten fusions and uses thereof |
| US10058624B2 (en) * | 2015-04-16 | 2018-08-28 | Emory University | Recombinant promoters and vectors for protein expression in liver and use thereof |
| MX2018001497A (es) | 2015-08-03 | 2018-05-15 | Bioverativ Therapeutics Inc | Proteinas de fusion de factor ix y metodos para producirlas y usarlas. |
| PE20231949A1 (es) | 2015-10-30 | 2023-12-05 | Spark Therapeutics Inc | VARIANTES DEL FACTOR VIII REDUCIDO CON CpG, COMPOSICIONES Y METODOS Y USOS PARA EL TRATAMIENTO DE TRASTORNOS DE LA HEMOSTASIA |
| WO2018102743A1 (en) | 2016-12-02 | 2018-06-07 | Bioverativ Therapeutics Inc. | Methods of treating hemophilic arthropathy using chimeric clotting factors |
| US20210093735A1 (en) * | 2018-04-26 | 2021-04-01 | The University Of North Carolina At Chapel Hill | Methods and compositions for treatment of hemophilia |
| RS66972B1 (sr) | 2018-05-18 | 2025-07-31 | Bioverativ Therapeutics Inc | Metode lečenja hemofilije a |
| US11795207B2 (en) | 2021-03-30 | 2023-10-24 | AAVnerGene Inc. | Modified plasma clotting factor VIII and method of use thereof |
| CN117157316A (zh) | 2021-03-30 | 2023-12-01 | 艾诺健基因治疗股份有限公司 | 修饰的血浆凝血因子viii及其使用方法 |
| CN113970279B (zh) * | 2021-10-26 | 2023-07-07 | 珠海城市职业技术学院 | 数字式螺旋测微仪 |
| CN114196677A (zh) * | 2021-12-30 | 2022-03-18 | 广西医科大学第一附属医院 | 一种高活性的凝血因子Ⅷ或Ⅷa多肽变体Gly710Ala |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663060A (en) * | 1992-04-07 | 1997-09-02 | Emory University | Hybrid human/animal factor VIII |
| US5744446A (en) | 1992-04-07 | 1998-04-28 | Emory University | Hybrid human/animal factor VIII |
| US6180371B1 (en) | 1996-06-26 | 2001-01-30 | Emory University | Modified factor VIII |
| US5888974A (en) * | 1992-04-07 | 1999-03-30 | Emory University | Hybrid human/animal factor VIII |
| US5859204A (en) | 1992-04-07 | 1999-01-12 | Emory University | Modified factor VIII |
| CA2225189C (en) * | 1997-03-06 | 2010-05-25 | Queen's University At Kingston | Canine factor viii gene, protein and methods of use |
| AU6770200A (en) * | 1999-08-13 | 2001-03-13 | Fred Hutchinson Cancer Research Center | Crystal of a truncated protein construct containing a coagulation factor viii c2domain in the presence or absence of a bound ligand and methods of use thereof |
| EP1460131A3 (en) * | 2000-03-22 | 2005-06-01 | Octagene GmbH | Production of recombinant blood clotting factors in human cell lines |
-
2001
- 2001-09-19 WO PCT/US2001/029431 patent/WO2002024723A1/en not_active Ceased
- 2001-09-19 PL PL366199A patent/PL206105B1/pl not_active IP Right Cessation
- 2001-09-19 AU AU2001292861A patent/AU2001292861A1/en not_active Abandoned
- 2001-09-19 HU HU0301179A patent/HUP0301179A3/hu unknown
- 2001-09-19 CA CA002422902A patent/CA2422902A1/en not_active Abandoned
- 2001-09-19 CN CNB018191495A patent/CN1205221C/zh not_active Expired - Fee Related
- 2001-09-19 JP JP2002529131A patent/JP2004525608A/ja active Pending
- 2001-09-19 KR KR1020037003993A patent/KR100638184B1/ko not_active Expired - Fee Related
- 2001-09-19 US US09/957,641 patent/US6770744B2/en not_active Expired - Fee Related
- 2001-09-19 EP EP01973263A patent/EP1319016A4/en not_active Withdrawn
- 2001-09-19 MX MXPA03002256A patent/MXPA03002256A/es active IP Right Grant
- 2001-09-19 RU RU2003107100/13A patent/RU2003107100A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004525608A (ja) | 2004-08-26 |
| RU2003107100A (ru) | 2004-08-27 |
| AU2001292861A1 (en) | 2002-04-02 |
| PL366199A1 (en) | 2005-01-24 |
| EP1319016A4 (en) | 2006-05-10 |
| US20020182670A1 (en) | 2002-12-05 |
| HUP0301179A2 (hu) | 2003-10-28 |
| KR100638184B1 (ko) | 2006-10-26 |
| KR20030033074A (ko) | 2003-04-26 |
| CN1205221C (zh) | 2005-06-08 |
| US6770744B2 (en) | 2004-08-03 |
| HUP0301179A3 (en) | 2006-11-28 |
| MXPA03002256A (es) | 2003-09-10 |
| WO2002024723A9 (en) | 2003-04-03 |
| WO2002024723A1 (en) | 2002-03-28 |
| EP1319016A1 (en) | 2003-06-18 |
| PL206105B1 (pl) | 2010-07-30 |
| CN1474830A (zh) | 2004-02-11 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request | ||
| FZDE | Discontinued |