CA2421388A1

CA2421388A1 - Novel poypeptides and nucleic acids encoding the same

Info

Publication number: CA2421388A1
Application number: CA002421388A
Authority: CA
Inventors: William I. Wood; Austin L. Gurney; Audrey Goddard; Kevin P. Baker; Jian Chen; Jean Yuan
Original assignee: Genentech, Inc.; William I. Wood; Austin L. Gurney; Audrey Goddard; Kevin P. Baker; Jian Chen; Jean Yuan
Current assignee: Genentech Inc
Priority date: 1998-03-10
Filing date: 1999-03-08
Publication date: 1999-09-16
Also published as: CA2421333A1; CA2421375A1; CA2421322A1; CA2421339C; CA2421319A1; CA2421315A1; CA2421364A1; CA2421345A1; CA2421394A1; CA2421372A1; CA2421329A1; CA2421339A1

Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Description

DE1~IANDES OU BREVETS VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DE1'I_.~i~IDE OU CE BREVETS
CO!~iPREND PLUS D'UN TOME.
CECI EST LE TOME ~ DE~
NOTE: Pour les tomes additionels, veillez contacter 1e Bureau Canadien des Brevets.
JUMBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION i PATENT CONTAINS WORE
THAN ONE VOLL VIE.
THIS IS VOLUItE~ OF
NOTE: For additional volumes please contact the Canadian Patent Office.

His Phe Leu Ala Leu Asp Ala Se.r Gln His SE:r Ser Leu Ser Thr 245 a50 255 Arg Phe Gly Thr Val Ala Val Pro A~;n Ile Leu Leu Phe Gln G1y Ala Lys Pro Met Ala Arg Phe Asn His Thr Asp Arg Thr heu Glu Thr Leu Lys I.le Phe Ile Phe Asn G1n 'I'hr Gly Ile Glu Ala Lys Lys Asn Val Val Val Thr Gln A1a P.sp Gln Ile Gly Pro Leu Pro Ser Thr Leu Ile Lys Ser Val Asp Trp Leu heu Val Phe Ser Leu Phe Phe Leu L1e Ser Phe Ile Met 'I'yr Ala 'Chr Ile Arg Thr Glu Ser Ile Arg Trp Leu Ile Pro Gly ~~ln Glu Gln Glu His Val Glu 350 3'_~5 360 <210> 411 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <:400> 411 cacagagcca gaagtggcgg aatc 24 <210> 412 <'211> 25 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-25 <223> Artificial Sequence <400> 412 ccacatgttc ctgct<atgt cctgg 25 <210> 413 <211> 45 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-45 <223> Artificial Sequence <400> 913 267.

cggtagtgac tgtactctag tcctgtttta cvacc:ccgtgg tgccg 45 <210> 414 <211> 1196 <212> DNA
<213> Homo Sapiens <400> 419 cccggctccg ctccctctgc cccctcgggg tcgcgc:gccc acgatgctgc 50 agggccctgg ctcgctgctg ctgctcatcc tcgccr_cgca ctgctgcctg 100 ggctcggcgc gcgggctctt cctctt:tggc cagcccg~.ct tct:cctacaa 1.50 gcgcagcaat tgcaagccca tcccggtcaa cctgcagctg tgccacggca 200 tcgaatacca gaacatgcgg ca gcccaacc tgctgggcca cgagaccatg 250 aaggaggtgc tggagcaggc cggcgcttgg atc:c:cgctgg tcatgaagco 300 gtgccacccg gacaccaaga agttcctgtg ctcgctcttc gcccccgtct 350 gcctcgatga cctagacgag accatccagc catgccactc gca ctgcgtg 900 caggtgaagg accgctgcgc cccgcltcatq tccg~~cttcg gcttcccctg 450 gcccgacatg cttgagtgcg accgtttccc: ccaggacaac gacctttgca 500 tccccctcgc tagcagcgac cacctcctgc; cagccac~cga ggaagctcca 550 aaggtatgtg aagcctgcaa aaataaaaat gatgatgaca acgacataat 600 ggaaacgctt tgtaaaaatg attttgcact gaaaataaaa gtgaaggaga 650 taacctacat caaccgagat accaaaatca tcctggagac caagagcaag 700 accatttaca agctgaacgg tgtgtccgaa agggacctga agaaatcggt 750 gctgtggctc aaagacagct tgcagtgcrac ctgtgaggag atgaacgaca 800 tcaacgcgcc ctatctggtc: atgggacaga aac;agggtgg ggagctggtg 850 atcacctcgg tgaagcggtg gcagaaggylg cagag,sgagt tcaagcgcat 900 ctcccgcagc atccgcaagc tgcagtgcta gtc:ccggcat cctgatggct 950 ccgacaggcc tgctccagag cac;ggctgac cat:ttctgct ccgggatc;tc 1000 agctcccgtt ccccaagcac aci:cctagct. gc:tcc.agtct. cagcctgggc 1050 agcttccccc tgccttttgc acgtttgc;at cr_ccagcatt. tcctgagtta 1100 taaggccaca ggagtggata gctgttttca cctaaaggaa aagcccaccc 1150 gaatcttgta gaaatattc:a aactaataaa atca~gaata ttttaa 1196 <210> 415 <21.1> 295 <212> PRT
<213> Homo Sapiens <900> 415 Met Leu Gln Gly Pro Gly Ser Leu Leu Leu Leu Phe Leu Ala Ser

2 c~ 2 His Cys Cys Leu Gly Ser Ala Arg G:iy Leu Phe Leu Phe Gly Gln Pro Asp Phe Ser Tyr Lys Arg Ser Asn Cy~s Lys Pro Ile Pro Val Asn Leu Gln Leu Cy~. His Gly Ile Glu Tyr Gln Asn Met Arg Leu Pro Asn Leu Leu Gly His Glu Thr Met Lys C~lu Vai Le~.a Glu Gin 65 '70 75 Ala Gly Ala Trp Ile Pro Leu Val Met: Lys c:~ln Cys His Pro Asp Thr Lys Lys Fhe Leu Cys Ser heu I?he Ala Fro Val Cys Leu Asp Asp Leu Asp Glu Thr Ile Glr: Pro Cys His Ser Leu Cys Val Gln 110 1:15 120 Val Lys Asp Arg Cys Ala Pro 'Jal Met Ser Ala Phe G1y Phe Pro Trp Pro Asp Met Leu Gl.u Cys Asp Arg Phe Pro Gln Asp Asn Asp Leu Cys Ile Pro Leu A:La Ser Ser Asp His Leu Leu Pro F.la Thr Glu Glu Ala Pro Lys Val Cys Glu Ala Cys Lys Asn Lys Asn Asp Asp Asp Asn Asp Ile Met Giu Thr Leu ~Cya Lys Asn Asp Phe Ala Leu Lys Ile Lys Val hys Glu IlcThr Ty° Ile Asn Arg Asp Thr 200 20'~ 210 Lys Ile Ile Leu Glu 'Chr Lys See Lys Thr Ile Tyr Lys Leu Asn Gly Val Ser G.lu Arg Asp Leu Lys Lys Ser Val Leu Trp Leu Lys 2.30 235 240 Asp Ser Leu Gln Cys Thr Cys Glu Glu Met Asn Asp Il.e Asn Ala Pro Tyr Leu Val Met Gly t~ln Lys C~ln Gl.y Gly Glu Leu Val Ile Thr Ser Val Lys Arg Trp Gln Lys Gly Gln Arg Glu Phe Lys Arg Ile Ser Arg Ser Ile Arg Lys Leu Gln Cys <210> 416 <211> 21 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-21 <223> Artificial Sequence <400> 416 cctggctcgc tgctgctgct c 21 <210> 417 <211> 25 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-25 <223> Artificial Sequence <400> 91.
cctcacaggt gcactgcaag ctgtc ''<:5 <2i0> 418 <211> 4.
<212> DNA
<213> Artificial <220>
<221> Artificial Sequence <:222> 1-47 <223> Artificial Sequence <400> 41S
ctcttcctct ttggccagcc cgacttctcc tacaaccgca gaatt.gc 47 <210> 419 <211> 1830 <212> DNA
<213> Homo Sapiens <400> 919 gtggaggccg ccgacgatgg cggggccgac ggaggccgag acggggttgg 50 ccgagccccg ggccctgtgc gcac<~gcggg gccaccgcac ctacgcgcgc 100 cgctgggtgt tcctgctcgc gatcagcctg ctcaactgct ccaacgccac 150 gctgtggctc agctttgcac ctgtggctga cgtcattgct gaggacttgg 200 tcctgtccat ggagcagat:c aactggctgt cactggtcta cctcgtggta 250 tccaccccat ttggcgtggc ggccatctgg atcctggact ccgtcgggct 300 ccgtgcggcg accatcctgg gtgcgtggct gaactttgcc gggagtgtgc 350 tacgcatggt gccctgcatg gttgttggga cccaaaaccc: atttgccttc 400 ctcatgggtg gccagagcct ctgtgccct.t gccc:agagcc. tggtcatctt 450 ctctccagcc: aagctggctg c<~ttgtggtt cccagagcac: cagcgagcca 500 cggccaacat gctcgccacc atgtcgaacc ctctgggcgt ccttgtggcc 550 aatgtgctgt cccctgtgct ggtcaagaag ggtgaggaca ttc~ugttaat 600 gctcggtgtc tataccatcc ctgctggcgt ;:gtctgcctg ctgtccacca 650 tctgcctgtg ggagagtgtg ccccccaccc ~gccca:ctgc cggggctgcc 700 agctccacct cagagaagtt cctagcatggg ct:caa<~ctgc agcacatgtg 750 gaacaaggcc tatgt.catcc tggctgtgtg cttggggclga at<~atcggga 800 tctctgccag cttctcagcc: ctcctggagc agatcctca g tgcaagcggc 850 cactccagtg ggttttccgg cctctgtggc gct<:tcti~ca tcacgtt_tgg 900 gatcctgggg gcactggctc tcggccccta tgtgGac::gg accaagcact 950 tcactgaggc caccaagatt ggcctgtgcc tgttca ct.ct ggcctgcgtg 1000 ccctttgccc tggtgtccca gctgcaggga cagac ccttg ccctggctgc 1050 cacctgctcg ctgctcgggc tgttt.ggctt ctcggtgggc cccgtggcca 1100 tggagttggc ggtcgagtgt tccttccccc; tggggg<iggg ggctgccaca 1150 ggcatgatct ttgtgctggg gcaggccgacggaatactca tcatgctggc 1200 aatgacggca ctgactgtgc gacgctcgga gccgtc~ttg tccacctgcc 1250 agcaggggga ggatccactt gactggacag tgtca ctgct gctgatggcc 1300 ggcctgtgca ccttcttcag ctgcat:cctg gcggtcttct tccac:acc<:c 1350 ataccggcgc ctgcaggccg agtcagggga gc.~.cccctcc acccgtaacg 1900 ccgtgggcgg cgcagactca gggccgggtg tggaccgagg gggagcagga 1450 agggctgggg tcctggggcc cag cacggc;g act.ccc~gagt gcacggcgag 1500 gggggcctcg ctagaggacc: ccagaggg.:c cgggagcccc cacccagcct 1550 gccaccgagc gactccccgt gcgcaaggcc cagcagccac cgacgcgccc 1600 tcccgccccg gcagactcgc aggcagggtc ca<3gcgtcca ggtttatt.ga 1650 cccggctggg tctcactcct cct:tctcctc cc~~gtgggtg atcacgtagc 1700 tgagcgcctt gtagtccagg ttgc~~cgcca catcgatgga ggcgaactgg 1750 aacatctggt ccacctgcgg gcgggggcga aaggg ctcct tgcgggctc:c 1800 gggagcgaat tacaagcgcg cacctgaaaa 1830 <210> 420 <211> 560 <212> PRT
<213> Homo Sapiens <400> 420 Met Ala Gly Pro Thr Glu A1a C~lu Thr Gly Leu Ala Glu Pro Arg 7. ' 10 15 Ala Leu Cys Ala Gln Arg Gly Isis Arg 'lhr Tyr Ala Arg Arg Trp Val Phe Leu Leu Ala Ile Ser Leu Lc=u Asn Cys Ser Asn Ala Thr Leu Trp Leu Ser Phe Ala Pro Val Ala Asp Val I1e Ala Glu Asp Leu Val Leu Ser Met Glu Gln Ile Asn Trp heu Ser Leu Val Tyr n;j 75 Leu Val Val Ser Thr Pro Phe Gly Val Ala Ala Ile Trp Ile Leu Asp Ser Val Gly Leu Arc, Ala Ala '"hr Ile Leu Gly Aia Trp Leu Asn Phe Ala Gly Ser Va1 Leu Arg Met Val Pro Cys Met. Val Val 11U 1~5 120 Gly Thr Gln Asn Pro Phe Ala Phe Leu Met Gly Gl.y Gln Ser Leu Cys Aia Leu Ala Gln Ser Le.a Val Ile Phe Ser Pro Ala Lys Leu 1.10 i45 150 Ala Ala Leu Trp Phe Pro Glu His Gln Arg Ala Thr Ala Asn Met 155 i60 165 Leu Ala Thr Met 5er Asn Pro Leu Gly Val Leu Val Ala Asn Val Leu Ser Pro Val Leu Val Lys Lys Gly Glu Asp 1:1e Pro L~eu Met '.85 190 195 Leu Gly Val Tyr 'I'hr Lle Pro Ala Gly Va:. Val Cys Leu Leu Ser Thr Ile Cys Leu Trp Glu Ser Val Pro Pry Thr Pro Pro Ser Ala Gly Ala Ala Ser Ser Thr Ser Glu Lys Phe Leu Asp Gly Leu Lys Leu Gln Leu Met Trp Asn Lys Ala Tyr Val I:Le Leu Ala Val Cys Leu Gly Gly Met Ile Gly Ile SE~r A1a Ser Phe Ser Ala Leu Leu Glu Gln Ila Leu Cys Ala Ser G1y His Ser Ser Gly Phe Ser Gly Leu Cys G1y Ala Leu Phe Il.e Thr Phe Gly Ile Leu Gly Ala Leu Ala Leu Gly Pro Tyr Val Asp Arg Thr hys His Phe Thr Glu Ala Thr Lys Ile Gly Leu Cys Leu Phe Ser :~eu A1a Cys Val Pro Phe 32(i 325 330 Ala Leu Val Ser Gln Leu Gln Gly Gln Thr Leu Ala Leu Ala Ala Thr Cys Ser Leu I:eu Gly Leu Phe G.'_y F?he Ser Val Gly Pro Val 350 35': 360 Ala Met Glu Leu Ala Val Glu Cys Sur Phe: Pro Val Gly Glu c,ly Ala Ala Thr Gly Met I1e Phe Val Leu Gly G1n Ala Glu Gly Ile Leu Tle Met. Leu Ala Met Thr Ala I..eu Thr Val Arg Arg Ser Glu Fro Ser Leu Ser Thr Cys Gln Gln Gly Glu asp Pro Leu Asp Trp Thr Val Ser Leu Leu Leu Met Ala Gly Leu Cys Thr Phe PY.e Ser Cys Ile Leu Ala Val Phe Phe fiis Thr Pro Tyr Arg Arg Leu Gln Ala Glu Ser Gly Glu Pro Pro Ser Thr Arg Asn Ala Val Gly Gly AIa Asp Ser Gly Pro Gly Val Asp Arg Gly Giy Ala G1y Arg Ala Gly Val Leu Gly Pro Ser Thr Ala Thr Pro Glu Cys Thr Ala Arg Gly Ala Ser Leu Glu Asp Pro Ara Gly Pro Gly Ser Fro His Pro Ala Cys His Arg Ala Thr Pro Arc, Ala Glr: Gly Pro Ala Ala Thr Asp Ala Pro Ser Arg Pro Gly Arg 'Leu Al,a Gly Arg Val Gln Ala Ser Arg Phe Ile Asp Pro F,la Gly Ser His Ser Ser Phe Ser Ser Pro Trp Val Ile Thr <210> 421 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-24 <22.3> Artificial Sequence <400> 421 agcttctcag ccctcctgga gc:ag 2~1 <210> 422 <211> 25 <212> DNA
<213> Artificial a: 6 7 <220>
<221> Artificial Sequence <222> 1-25 <223> Artificial. Sequence <400> 422 cgggtcaata aacctggacg cttgg 2'>
<210> 423 <211> 93 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-43 <223> Artificial Sequence <400> 423 tatgtggacc ggaccaagca cttcactgaq gccaccaaga ttg 43 <210> 429 <21i> 4313 <212> DNA
<213> Homo Sapiens <400> 429 gtcccacatc ctgctcaact gggt.caggtc cctcttagac cagctcttgt 50 ccatcatttg ctgaagtgga ccaac~agtt ccccaqtagg <~ggtctcccc 100 tggcaattct tgatcggcgt ttggacatca cagatc:gctt_ ccaatgaaga 150 tggccttgcc ttggggtcct gcttgttt~:a taatc.3tcta actatgggac 200 aaggttgtgc cggcagctct gggggaagga gcacggggct gatcaagcca 250 tccaggaaac actggaggac ttgtccagcc tt:gaaagaac tctagtggtt 300 tctgaatcta gcccacttgg cggtaagcat gatgcaactt ctgcaacttc 350 tgctggggct. tttggggcca ggtggctact tattt:ctttt aggggattgt 900 caggaggtga ccactctcac ggtgaaatac caagrgtcag aggaagtgcc 450 atctggtaca gtgatcggga agctgtc~~ca ggaactgggc cgggaggaga 500 ggcggaggca agctggggcc: gc.cttccagg tc~ttgcagct gcctcaggcg 550 ctccccattc aggtggactc tcxaggaaggc ttgca cagca caggcaggcg 600 gctggatcga gagcaqctgt gccgacagtg ggat:ccctgc ct.ggtttcct 650 ttgatgtgct tgccacaggg gatttgctctc tga~_ccatgt ggagatccaa 700 gtgctggaca tcaatgacca ccagccacgg t.tt::ccaaag gcgagcagga 750 gctggaaatc tctgagagcg cct.ctctgcg aacccggatc cccctggaca 800 gagctcttga cccagacaca ggccctaaca ccc.tgcacac ctacactctg 850 tctcccagtg agcactttgc cttggatgtc att:gtgggcc ctgatgagac 900 caaacatgca gaactcatag tggtgaagga gctggacagg gaaatccatt 950 cattttttga tctggtgtta actgcctatg acaatgggaa cccccccaag 1000 t;~aggtacca gcttggtcaa ggtcaacgtc ttggactcca atgacaatag 1050 ccctgcgttt gctgagagtt cactggcact ggaaatccaa gaagatgctg 1100 cacctggtac gcttctc<~ta aaactc3a~~cg ccacagaccc tgaccaaggc 1150 cccaatgggg aggtggagtt catcctcagt aagcaca:gc ctccagaggt 1200 gctggacacc ttcagtattg atgccaagac aggcc:aggtc attctgcgtc 1250 gacctctaga ctatgaaaag aaccctgcct acgac3gtgga tgttcaggca 1300 agggacctgg gtcccaatcc tatcc;cagcc cattgcaaag ttctcatca<~ 1350 ggttctggat gt.caatgaca acatcccaag catccacgtc acatgggc:ct 1400 cccagccatc actggtgtca gaagctcttc: ccaaggacag ttttattgct 7.450 cttgtcatgg cagatgactt ggattcagga caca.atggtt tggtccactg 1500 ctggctgagc caagagctgg gccacttcag gctgaaaaga actaatgg<:a 1550 acacatacat gttgctaacc aatgcc:acac tggacagaga crcagtggccc 1600 aaatataccc tcactctgtt agcr:caagac caaggactcc agccctta~c 1650 agccaagaaa cagctcagcs ttcagatcag tgacat:caac gacaatgcac: 1700 ctgtgtttga gaaaagcagg tatgaagtct ccacgcggga aaacaactta 1750 ccctctcttc acctcattac~ catcaaggc t catgatgcag acttgggc:at 1800 taatggaaaa gtctcatacc gcatc;cagga ctccccagtt gctcactt.ag 1850 tagctattga ctccaacaca ggag<aggtca ctgctcagag gtcactgaac 1900 tatgaagaga tggccggctt tgagttcc,ag gtgat:cgcag aggacagcgg 1950 gcaacccatg cttgcatcca gtg tctc'-gt gtgggtcagc ctcttggatq 2000 ccaatgataa tgccccagag gtggtccagc ct.gt:~ctcag cgatggaaaa 2050 gccagcctct ccgtgcttgt gaat.gcctcc acaggccacc tgctggi:gcc 2100 catcgagact cccaatggct tgggcccagc gggc:actgac; acacctccac 2150 tggccactca cagc:tcccgg cc:attccttt tgac;aaccai: tgt ggcaaga 2200 gatgcaga<a. cgggggcaaa tggagagccc: ctci.acagca tccgcaatgg 2250 aaatgaagcc cacctcttca tcctcaaccc: tcatacgggg cagctgttcg 2300 t.caatgtcac caatgccagc ;gcctc:~t:tu ggagtgagtg ggagctggag 2350 atagtagtag aggaccaggg aagccccccc ttacagaccc gagccctgtt 2900 gagggtcatg tttgtcacca gtgtggacca ~~ct.gagggac tcagcccgca 2450 agcctggggc cttgagcatg tcgatgctga cggtgatctg cctggctgta 2500 ctgttgggca tcttcgggtt gatcctgcct ctgttc:atgt ccatctgccg 2550 gacagaaaag aaggacaaca gggcctacaa ctgtcgggag gcc.gagtcca 2600 cctaccgcca gcagcccaag aggcccc<~ga aacacattca gaaggcagac 2650 atccacctcg tgcctgtgct caggggtcag gcaggtgagc cttgtgaagt 2700 cgggcagtcc cacaaagatg tggacaagga gg<:gatg<stg gaagcaggct 2750 gggacccctg cctgcaggcc cccttccacc tcacc:ccgac cctgtacagg 2800 acgctgcgta atcaaggcaa ccagggagca ccgg<:ggaga gccgagaggt 2850 gctgcaagac acggtcaacc tcctttt,caa ccatcccagg cagaggaatg 2900 cctcccggga gaacctgaac cttcc~cgagr cccagcc:tgc cacagcaccag 2950 ccacgttcca ggcctctgaa ggttgcaggc agccccacag ggaggctggc 3000 tggagaccag ggcagtgagg aagccccac-3 gaggccacca gcctcctctg 3050 caaccctgag acggcagcga catc:tcaatg gcaaagtgtc ccctgagaaa 3100 gaatcagggc cccgtcagat cctgcggaac ctggtccggc t.gtctgtggc 3150 tgccttcgcc gagcggaacc ccgt:ggagga gctcaca gtg gattctcctc 3200 ctgttcagca aatctcccag ctgctgtcca tgctgc:atca gggccaattc 3250 cagcccaaac caaaccaccg aggaaataag tacttggcca agccaggagg 3300 cagcaggagt gcaatcccag acacagatgg ccc:aagtgca agggctggag 3350 gccagacaga cccagaacag gar,gaagggc ca ttggatcc tgaagaggac 3400 ctctctgtga agcaactgct agaagaagag ctgtcaagtc tgctggaccc 3450 cagcacaggt ctggccctgg acc:ggctgag cgcccctgac ccggcctgga 350C
tggcgagact ctctttgccc ctcacca~:ca actaccgtga caatgtgatc 3550 tccccggatg ctgcagccac ggaggag~~cg aggaccttcc agacgttcgg 3600 caaggcagag gcaccagagc tgagcccaac aggcacgagg ctggccagca 3650 cctttgtctc ggagatgagc tc;actgctgg agatgctgct: ggaacagcgc 3700 tccagcatgc ccgtggaggc cgcctcc:gag gcgc:tgcggc ggca ctcggt 3750 ctgcgggagg accctcagtt tagacttggc: c:accagtgca gcctcaggca 3800 tgaaagtgr_a aggggaccca ggtggaaaga cggg gactga gggcaagagc 3850 agaggcagca gcagcagcag caggtgcctg t:gaacatacc tcagacgcct 3900 ctggatccaa gaaccagggg c:ctegaggatc r_gtggacaag agctggtttc 3950 taaaatcttg taactcacta gcT,agcggcg gccagagaac tttagggtga 4000 ctgatgctac ccccacagag gaggcaagag ccccaggact aacagctgac 4050 '270 tgaccaaagc agccccttgt aagcagctct ~_~agtcttt-,_g gaggacaggg 4100 acggtttgtg gctgagataa gt:.gtttcctg gcaaaacata tgtggagcac 4150 aaagggtcag tcctct.ggca gaacagatgc cacggagtat. cac:aggcagg 4200 aaagggtggc cttcttgggt agcaggagtc agggggctgt. accctggggg 9250 tgccaggaaa tgctctctga cctatcaata aaggaaaagc agtaaaaaaa 9300 aaaaaaaaaa aaa 4313 <210> 425 <211> 1109 <212> PRT
<?13> Homo Sapiens <400> 425 Met. Met GIn Leu Leu Gln Leia Leu Leu Gly Leu Leu C>Iy P.ro Gly Gly Tyr Leu Phe Leu Leu Gly Asp Cys Gln Glu Val Thr Thr Leu Thr Val Lys Tyr Gln Val Seer Glu Glu Val Pro Ser Cly Thr Val.

Ile Gly Lys Leu Sex Gln Gnu Lei: Gl.y Arcr Glu Glu Arg Arg Arg 50 5'~ 6C
Gln Ala Gly Al.a Ala Phe Gln Vas Leu Gl~.z Leu Pro Gln Ala Leu Pro Ile Gln Val Asp Ser Glu Glu Gly Leu Leu Ser Th r Gly Arg Arg Leu Asp Arg Glu Gln heu Cys Arg Gln Trp Asp Pro Cys Leu Val Ser Phe Asp Val Leu Ala Thr Gly Asp Leu Ala Leu Ile His Val Gl.u Ile Gln Val Leu Asp ILe Asn Asp His Gln Prc: Arg Fhe Pro Lys Gly Glu Gln Glu Leu Glu Ile ~~er Glu Ser Ala Ser Leu Arg Thr Arg Ile Pro Leu Asp Arg Al.a ';.eu Asp Pro Asp Thr Gly Pro Asn Thr Leu His Thr T'yr Thr Leu Ser Pro Ser Glu His Phe Ala Leu Asp Val Ile Val Gly Prc Asp Glu Thr Lys His Ala Glu Leu Ile Val Val Lys Glu Leu Asp Arg Glu Ile His Ser Phe Phe 200 205 2.10 Asp Leu Val Leu Thr Ala Tyr Asp Asn Gly Asn Pro Pro Lys Ser Gly Thr Ser Leu Val Lys Val Asn Val Leu Asp Ser Asn Asp Asn Ser Prc Ala Fhe Ala Glu Ser Se.~_ Leu Rl.a Leu Glu Ile Gln Glu Asp Ala Ala Pro Gly Thr Leu Leu Ire Lys LE:u Thr Ala Thr Asp Pro Asp Gln Gly Pro Asn Gly Glu Val Glu Phe Phe Leu Ser Lys His Met Pro Pro Glu Val Leu Ash Tt~r Phe Ser Ile Asp Ala Lys Thr Gly Gln Val Ile Leu Arg Arg Pao Leu Asp Tyr Glu Lys Asn 305 310 :815 Pro Ala Tyr Glu Val Asp Val Gln A.ia Arg Asp Leu Gly Prc Asn 320 325 :330 Pro Ile Pro Ala His Cys Lys Val Leu Ile Lys Val Leu Asp Val Asn Asp Asn Ile Pro Ser Ile His V<il Thr Trp Ala Ser Gln Prc 350 35~:~ 360 Ser Leu Val Ser Glu Ala Leu Pro Lys Asp Ser Phe Ile Ala Leu Val Met Ala Asp Asp Leu Asp Ser Gly His Asn Gly Leu Vai His 380 j8'i 390 Cys Trp Leu Ser Gln Glu Leu Gly His Phe Arg Leu Lys Arc_ Thr Asn Gly Asn Thr Tyr Met Leu LE:u Thr Asn Ala Thr Leu Asp Arg 97.C 915 920 G'~u Gln Trp Fro Lys Tyr Thr Leu Thr l.,eu Leu Ala Gln Asp Gln Gly Leu Gln Fro Leu Ser Aia Lys L~ys Gln heu Ser Ile Gln Ile Ser Asp Ile Asn Asp Asn Ala Pro V'al Phe Glu Lys Ser Arg Tyr Glu Val Ser Thr Arg Glu Asn Asn Iaeu Pro :aer Leu His Leu Ile Thr Ile Lys Ala His Asp Ala Asp l.~eu Gly ;1e Asn Gly Lys Val Ser Tyr Arg Ile Gln Asp Ser Pro Val Al.a His Leu Val Ala Ile Asp Ser Asn Thr Gly Glu Val Thr Ala Gln i~rg Ser Leu Asn Tyr Glu Glu Met Ala Gly Phe Glu Phe (~ln Val Ile Ala Glu Asp Ser 2a.

Gly Gln Pro Met Leu Ala Ser Ser Val Ser Val Trp Val Ser Leu Leu Asp Ala Asn Asp Asn Ala Pro Glu 'v'al Val Glr: Pro Val Leu Ser Asp Gly Lys Ala Ser Leu Ser Val Leu Val Asn Ala Ser Thr Gly His Leu Leu Val Pro Ile Glu Thr Pro Asn Gly Leu Gly Pro Ala Gly Thr Asp Thr Pro Pro Leu Ala 'nhr His Ser Ser Arg Pro Phe Leu Leu Thr 'Ihr Ile Val A-~a Arg Asp F.la Asp Ser Gly Ala Asn Gly Glu Pro Leu Tyr Ser Ile Arg Asn C~ly Asn Glu Ala His 635 fig ~ 695 Leu Phe Ile Leu Asn Pro fii.s Thr Gly Gln Leu Phe Val Asn Val Thr Asn Ala Ser Ser Leu Ile Gly ;per Glu 'Trp Glu Leu Glu Ile Val Val Glu Asp Gln Gly Ser Pro Fro Leu C~lr. Thr Arg Ala Leu Leu Arg Val Met Phe Val Thr S~~r Val Asp His Leu Arg Asp Ser Ala Arg Lys Pro Gly Ala Leu Ser Met Ser Met Leu Thr Va1 Ile Cys Leu Ala Vai Leu Leu Gly Ile f'he Gl.y Leu Ile Leu Ala Leu Phe Met Ser Ile Cys Ar_q Thr Glu Lys Lys Asp Asn Arg Ala Tyr Asn Cys Arg Glu Ala Glu Ser Thr '1'yr Arg Gln Gln Pro Lys Arg 755 '7Ei0 765 Fro Gln Lys His Ile Gln Lys Ala Asp Ile His Leu Val Pro Val Leu Arg Gly Gln Ala Gly Glu Pro c.,ys Glu b'al Gly Gln Ser His Lys Asp Val Asp Lys Glu Ala Met Met Glu .~la Gly Trp Asp Pro Cys Leu Gln Ala Pro Phe His Leu Thr Pro Thr Leu Tyr Arg Thr 815 82'0 ~025 Leu Arg Asn Gln Gly Asn Gln Cly Ala Pro Ala Glu Ser Arg Glu Val Leu Gln Asp Thr Val Asn L,eu :Leu Phe Asn His Pro Arg Gln 2 '7 3 Arg Asn Ala Ser Arg Glu Asn Leu Asn Leu Pro Glu Pro Gln Pro Ala Thr Gly Gln Pro Arg Ser ,Arg P.ro Leu Lys Val. Ala Gly Ser Pro Thr Gly Arg Leu Ala G1y Asp GIn G1y S~~r Glu Glu A1a Pro Gln Arg Fro Pro Aia Ser Ser Ala Thr Leu Arg Arg Gln Arc His Leu Asn Gly Lys Val Ser Pro Glu Lys Glu Ser Gly Pro Arg Gln Ile Leu Arg Ser Leu Val Arg LE:u Ser Val Ala Ala Phe Ala Glu Arg Asn Pro Val. Glu Glu Leu Thr Val Asp ~er Pro Pro Vai Gln Gln Ile Ser Gln Leu Leu Ser Leu l.eu His C~ln Gly Glr. Phe Gln Pro Lys Pro Asn His Arg Giy Asn I,ys Tyr I~eu Ala Lys Pro Gly 98(7 985 990 Gly Ser Arg Ser Ala Ile Pro Asp 'I'hr Asp Gly Pro Ser Ala Arg Ala Gly Gly Gln Th.r Asp Pro Glu Gln Glu Glu Gly Pro Leu Asp Pro Glu Glu Asp Leu Ser Val Lys Gln Leu Leu Glu Gl.u Glu Leu 1025 10?0 1035 Ser Ser Leu Leu Asp Pro Ser Thr ,1y Leu Ala Leu Asp Arg Leu Ser Ala Pro Asp Pro Ala Trp Met Ala Arg Leu Ser Leu Prc Leu 1055 10Ei0 1065 Thr Thr Asn Tyr Arg Asp Asr: Va1 Ile Ser Pro Asp Ala A:a Ala 10'70 10'75 1080 Thr Glu Glu Pro Arg Thr Phe Gln Thr Phe Gly Lys Al.a Glu Ala Pro Glu Leu Ser Pro Thr Gly 'Phr Arg Leu Ala Ser Thr Phe Val Ser Glu Met Ser Ser Leu Leu Glu Met Leu Leu Glu Gi.n Arq_ Ser 1115 1120 1.125 Ser Met Pro Val Glu Al.a Al.a Ser Glu Ala Leu Arg Arg Lec.z Ser Val Cys Gly Arg Thr Leu Ser Leu Asp I.,eu A.la Thr Ser Ala Ala Ser Gly Met Lys Val Gln Gly Asp Pro Gly Gly Lys Thr Gly Thr 11E;0 1165 11'10 2 ?4 Glu Gly Lys Ser Arg Gly Ser Ser Ser Ser Ser Arg Cys Leu <210> 426 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <900> 926 gtaagcacat gcctccagag gtgc 24 <210> 927 <211> 29 <212> DNA
<2i3> Artificial <220>
<221> Artificial Sequence <222> 1-29 <223> Artificial Sequence <400> 427 gtgacgtgga tgcttgggat gttg 29 <210> 428 <211> 50 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-50 <223> Artificial Sequence <900> 928 tggacacctt cagtattgat gccaagacag gccaggtcat tctgcgtcga 50 <210> 929 <211> 2037 <212> DNA
<213> Homo Sapiens <400> 929 cggacgcgtg ggcggacgcg tgggggagaa ccgcagt:ccc ggctgcagca 50 cctgggagaa ggcagaccgt gtgagggggc° ctgtggc~ccc agcgtgctgt 100 ggcctcgggg agtgggaagt ggaggcagg<i gccttcctta cacttcgcca 150 tgagtttcct catcgactcc agcatcatg._i tt.acct~,:cca gatactattt 200 tttggatttg ggtggctttt cttcatgcg~: caattgttta aagactatga 250 gatacgtcag tatgttgtac aggtgatctt ctcc:gtgacg tttgcatttt 300 cttgcaccat gtttgagctc atcatctttg aaatcttagg agtattgaat 350 2'75 agcagctccc gttattttca ctggaaaatg aacctgtgt:g taattctgct 400 gatcct.ggtt ttcatggtgc ctttttac.at tggctatttt attgt.gagca 450 atatccgact actgcataaa caacgactgc t ttttt.cctg tctcttatgg 500 ctgaccttta tgtatttctt ctggaaa cta ggagatccct ttcccattct 550 cagcc-caaaa catgggatct tatccataga a~cagctcatc agccgggttg 600 gtgtgattgg agtgactctc atggctcttc tttctggatt tggtgctgtc 650 aactgcccat acacttacat gtcttacttc ~~tcaggaatg tgactgacac 700 ggatattcta gccctggaac ggcgac:tgct gcaaaccatg gatatgatca 750 taagcaaaaa gaaaaggatg gcaatggcac ggaga<scaat gtt:ccagaag 800 ggggaagtgc ataacaaacc atcaggtttc tggggaat.ga taaaaagtgt 850 taccacttca gcatcaggaa gtgaaaatct tactcttatt caacaggaag 900 tggatgcttt ggaagaatta agcaggcagc tttttctgga aacagctgat 950 ctatatgcta ccaaggagag aatagaatac tcc:aaaac~ct tcaaggggaa 1000 atattttaat tttcttggtt actttttctc ta~~tt:acvgt gtttggaaaa 1050 ttttcatggc taccatcaat attgtttttg atcgagttgg gaaaacggat 1100 cctgtcacaa gaggcattga gatcactgtg aattatctgg gaatccaatt 1150 tgatgtgaag ttttggtccc aacacatttc ctt.cattctt gttggaat.aa 1200 tcatcgtcac atccatcaga ggattgctga tcactcttac caagttcttt. 1250 tatgccatct ctagcagtaa gtcct.ccaat gtcattgtcc tgctattagc 1300 acagataatg ggcatgt.act ttgtc~tcctc: tatgctc~ctg atccgaatga 1350 gtatgccttt agaataccgc accar_aatc~; ctgaagtcct tggagaactg 1900 cagttcaact tctatcaccg ttggtttgat gtgatcitcc tggtcagcgc 1950 tctctctagc atactcttcc tctatttggr tcacaaa cag gcaccagaga 1500 agcaaatggc accttgaact taagcctact acagactgtt agaggccagt 1550 ggtttcaaaa tttagatata agagggggga aaaatggaac cagggcctga 1600 cattttataa acaaacaaaa tgctatggta gcat:ttttca ccttcatagc 1650 atactccttc cccgtcaggt gatact:atga ccat=gagtag c:atcagccag 1700 aacatgagag ggagaactaa ctcaagacaa tactcagcag agagcatccc 1750 gtgtggatat gaggctggtg tagaggcgga gaggacccaa gaaactaaag 1800 gtgaaaaata cactggaact ctggggcaag acatgt.ctat ggtagctgag 1850 ccaaacacgt aggatttccg ttttaaggt.t cacatggaaa aggttatagc 1900 tttgccttga gattgactca ttaaaatcag agactgtaac aaaaaaaaaa 1950 aaaaaaaaaa agggcggccg cgactctaga gtcgacctcac agaagcttgg 2000 ccgccatggc ccaacttgtt tattgcagct tataatg :%037 <210> 430 <2I1> 455 <2i2> PRT
<.273> Homo sapiens <400> 430 Met Ser Phe Leu Ile Asp Ser Ser Ile Mei= Ile Thr Ser Gln Ile Leu Phe Phe Gly Phe Gly Trp Leu Phe Phe filet Arc:l Gln Lea Fhe Lys Asp Tyr Glu Ile Arg Gln T-yr Val Val c~ln Va.L Ile Phe Ser Val Thr Phe Ala Phe Ser Cys Thr Met Phe Glu Leu Ile Ile Phe C:lu Ile Leu Gly Val Leu Asn Ser Ser Seer Arg Tyr Phe His Trp hys Met Asn Leu Cys Val Ile Leu Leu Ile Leu Val Phe Met Val 80 :>5 90 Pro Phe Tyr ile Gly Tyr Phe Ile Val Ser Asn Il.e Arg Leu Leu His Lys Gln Arg Leu Leu Phe~ Ser Cys L~au Leu Tt:p Leu Thr Phe Met Tyr Phe Phe Trp Lys Leu Gly Asp Pro Phe Pro Ile Leu Ser Pro Lys His Gly I1e Leu Ser Ile Glu Gln Leu Ile Ser Arg Val Gly Val. Ile Gly Val Thr Leu Met Ala L,eu Leu Ser Gly Fhe Gly Ala Val Asn Cys Pro Tyr Thr Tyr Met Ser Tyr Fhe Leu Arg Asn 170 ~-75 180 Val Thr Asp Thr Asp Ile Leu Ala Leu Glu Arg Arg Leu Leu Gln Thr Met Asp Met: 11e Ile Ser Lys. Lys Ly:~ Arg Met Ala Met Ala Arg Arg Thr Met Phe Gln Lys Gly Glu Va:. His Asn Lys .Pro Ser Gly Phe Trp Gly Met Ile Lys Ser Val Th:r Thr Ser A1a Sex Gly 230 23 ~~ 240 Ser Glu Asn Leu Thr Leu Ile Gln Gln Glu Val Asp A1a Leu Glu 245 25(7 255 Glu Leu Ser Arg Gln Leu Phe Lea Glu Thr Ala Asp Leu Tyr Ala ;? 7 7 Th r Lys Glu Arg Ile Glu Tyr Ser Lys Thr Phe Lys Gly Lys Tyr Phe Asn Phe Leu Gly Tyr Phe Phe Ser Ile Zyr Cys Val Trp Lys Ile Phe Met Ala Thr Ile Asn Ile Val I?he F~sp Arg Val Gly Lys 30'i 310 31.5 Thr Asp Pro Val Thr Arg Gly Ile t,lu Ile ~~hr Val Asn Tyr Leu Gly Ile Gln F~he Asp Val Lys Phe '!'rp Ser ~~ln His Ile Ser Phe Ile Leu Val Gly Ile Ile Ile Val Thr Ser Ile Arg Gly Leu Leu Ile Thr Leu Thr Lys Phe Phe Tyr .Alts Ile Ser Ser Ser Lys Ser Ser Asn Val Ile Val Leu Leu Leu Ala Gln Il.e Met Gly Met Tyr Phe Val Ser Ser Val Leu Leu Ile Arg Met Ser Met Pro Leu Glu Tyr Arg Thr Ile Ile Thr Glu Val Leu Gly Glu Leu Gln Phe Asn Phe Tyr His Arg Trp PY~e Asp Val Ile Phe Leu Val Ser Ala Leu Ser Ser Ile Leu Phe Leu Tyr Leu Alts His Lys Gln Ala F'ro Glu Lys Gln Met Ala Fro <210> 931 <211> 407 ~:212> DNA
<213> Homo Sapiens <220>
<221> unsure <222> 78, 81, 113, 15;, 229, 29' <223> unknown base <400> 931 catgggaagt ggagccggag ccttccttac act.cg:~catg agtttcctca 50 tcgactccag catcatgatt accts cccnga nactattttt tggatttggg 100 tggcttttct tcngcgccaa tgttt:aaaga ctatgagata cgtcagtatg 150 ttgtacnggt gatcttctcc gtgac:gtttg ccatttcttg caccatgttt 200 gagctcatca tctttgaaat ctr_nggaqta ttgaatagca gctcccgtta 250 ttttcactgg aaaatgaacc tgtgtgtaat tctgc:tgatc ctggttntca 300 tggtgccttt ttacattggc tattttattg tgagcaatat ccgactactg 350 cataaacaac gactgctttt ttcctgtctc ttat:ggctga cctttat.gta 400 tttCCag 4~7 <210> 932 <211> 457 <212> DNA
<213> Homo Sapiens <220>
<221> unsure <222> 31, 6F, 81-82, 89, 122, 184, 187, 2:~2, 291, 900, 424, 427, 439 <223> unknown base <400> 432 gtgttgccct tggggagggg aaggggagcc nggecctttc ctaaaatttg 50 gccaagggtt tctttnttga attccgggtt nngnatacct tcccagaaaa 100 tattttttgg atttggggta gntttttttc atgcgccaat tgtttaaaga 150 ctatgagata cgtcagt.atg ttgt<~caggt gatnttntcc gt:gacgtttg 200 cattttcttg caccatgttt gagctcatca tntttgaaat nt=taggagta 250 ttgaatagca gctcccgtta ttttcactgci aaaatge3ar_c tgtgtgtaat 300 tctgctgatc <a ggttttca tggtgcctt~ ttacat:.ggc tattttattg 350 tgagcaatat ccgactactg cataaacaac gactgctttt ttcctgtctn 400 ttatggctga cctttatgta tttnttntgg aaantaggag atccctttcc 450 cattctc 457 <210> 433 <211> 20 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-20 <223> Artificial Sequence <400> 433 aagtggagcc ggagccttcc 20 <210> 934 <211> 22 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-22 <223> Artificial Sequence <900> 434 tcgttgttta tgcagtagtc gg 22 <210> 435 <211> 9i <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> l.-41 <223> Artificial Sequence <900> 935 attgtttaaa gactatgaga t.acgtcagta tgttgtac~ag g 41 <210> 936 <211> 3951 <212> DNA
<213> Homo sapiens <900> 936 ctcgcgcagg gatcgtccca tggccggggc tcggagccgc gacccttggg 50 gggcctccgg gatttgctac ctttttggct ccctgctcgt cgaactgctc: 100 ttctcacggg ctgtcgcctt caatctggac- gtgatgctgtg ccttgcgcaa 7.50 ggagggcgag ccaggcagcc tcttcggctt ctct:gtggcc ctgcaccggc 200 agttgcagcc ccgaccccag agctggctgc tggtgg3tgc tccccaggcc 250 ctggctcttc ctgggcagca ggcgaatcgc actc7gaggcc t.cttcgctt.g 300 cccgttgagc ctggaggaga ctgact:gcta cag<~gtggac atcgaccagg 350 gagctgatat gcaaaaggaa agcaaggaga accagtggtt. gggagtcagt 900 gttcggagcc aggggcctgg gggcaagatt gttaccagtg cacaccgata 45G
tgaggcaagg cagcgagtgg accagatcc:t ggagacgcgg gatatgattg 500 gtcgctgctt tgtgctcagc: caggacct~~g ccatcc~ggga tgagttggat 550 ggtggggaat ggaagttctg tgagggacgc ccc:caaggcc atgaacaatt 600 tqggttctgc cagcagggca cagctgccgc ctt:ctcccct gatagccact 650 acctcctctt tggggcccca ggaacctata attggaaggg cacggccagg 700 gtggagctct gtgcacaggg ctcagcggac ctggc:acacc tggacgacgg 750 tccctacgag gcggggggag agaaggagca ggacccccgc ctcatcccgg 800 tccctgccaa cagctactt.t ggcttctca a ttgactcggg gaaaggtctg 850 gtgcgtgcag aagagctgag ctttgtggct ggagcccccc gcgccaacca 900 caagggtgct gtggtcatcc tgcgcaagga cagcgccagt cgcctggtgc 950 ccgaggttat gctgtctggg gagcgcctga cca ccggctt tggctac;tca 1000 ctggctgtgg ctgacctcaa c~:gt=gatggc t.ggccagacc: tgatagtggg 1050 tgccccctac ttctttgagc gccaagaaga gctggggggt gct.gtgtatg 1100 tgtacttgaa ccaggggggt cactgggc:tg ggatct=cccc tctccggctc 1150 tgcggctccc ctgactccat gttcgggatc agcct:~gctg i:.cctggggga 1200 cctcaaccaa gatggctttc cagataittgc agtgggtgcc ccctttgatg 1250 gtgatgggaa agtcttcatc taccat:.ggga gcagcct<~gg ggttgtcgcc 1300 aaaccttcac aggtgctgga gggcgaggct gtgggca~~ca ag;agcttcgg 1350 ctactccctg tcaggcagct tggatatgga tgggaac~~aa taccctgacc 1400 tgctggtggg ctccctggct gacaccgcag tgct<a tcag ggccagaccc 1450 atcctccatg tctcccatga ggtctctatt gctccacgaa gcatcgacct 1500 ggagcagccc aactgtgctg gcggc:cactc ggtctgtgtg gacctaaggg 1550 tctgtttcag ctacatt:gca gtccc cagca gctatagccc tactgt.ggcc 1600 ctggactatg tgttagatgc ggac.acagac: cggaggctcc ggggccaggt 1650 tccccgtgtg acgttcctga gccgtaacct ggaagaac<:c aagcaccagg 1700 cctcgggcac cgtgtggct.g aagcaccagc atgaccgagt ctgtggagac 1750 gccatgttcc agctccagga aaatgtcaaa gacaagcttc gggccattet 1800 agtgaccttg tcctacagtc tccagaccctcggctccgg cgacaggctc 1850 ctggccaggg gctgcctcca gtggccccca tcctcaatgc ccaccagcc:c 1900 agcacccagc gggcagagat ccacttcctg aagcaaggct gtggtgaaga 1950 caagatctgc cagagcaatc tgcag~;tgcrt ccacg<.~ccgc ttctgtaccc 2000 gggtcagcga cacggaattc caacctctc~c c~catgc~atgt ggatggaaca 2050 acagccctgt ttgcactgag tgggcagcca gtcattggcc tggagctgat 2100 ggtcaccaac ctgccatcgg acccagccca gcc:ccaggct gatggggatg 2150 atgcccatga agcccagct:: ctggtcatgc ttcctgactc actgcact.ac 2200 tcaggggtcc gggccctgga cccagcggag aagccactct gcctgtcc:aa 2250 tgagaatgcc tcccatgttg agt:gtgagct ggggaacccc atgaagagag 2300 gtgcccaggt. caccttctac ctcatcctta gcacctccgg gatcagcat.t 2350 gagaccacgg aactggaggt agagctgc:tg tt.ggccacga tcagtgagca 2400 ggagctgcat ccagtctctg racgagc<;cg tgtcttcatt gagctgccac 2450 tgtccattgc aggaatggcc attccccagc aactcttctt ctctggtgtg 2500 gtgaggggcg agagagccat gc:agtctgag cgggatgt.gg gcagcaaggt 2550 caagtatgag gtcacggttt cc:aaccaagg ccagtcgctc: agoaccctgg 2600 gctctgcctt cctcaacatc atgtggcctc atgagattgc caatgggaag 2650 tggttgctgt acccaatgca ggttgagctg gagggc:gggc aggggcctgg 2700 gcagaaaggg ctttgctctc ccaggc:c<:aa catcc:tccac <;tggatgtgg 2750 acagtaggga taggaggcgg cgggagctgg agccacct:ga gcagcaggag 2800 cctggtgagc ggcaggagcc c:agcatgtcc tggtggcc:ag tgtcctctgc 2850 tgagaagaag aaaaacatca <:cctggactg cgcccggc.~gc acggccaact 2900 gtgtggtgtt cagctgccca ca ctacagct ttgac:cgcgc ggctgtgctg 2950 catgtctggg gccgtctctg gaacagcacc tttct~ggagg agtactcagc: 3000 tgtgaagtcc ctggaagtga ttgtccgggc caacatcaca gt.gaagtcct 3050 ccataaagaa cttgatgctc cgagatgcct ccacagt.gat cc:cagtgatg 3100 gtatacttgg acc:ccatggc tgtggtggca gaaggac)tgc cct.ggtgggt 3150 catcctcctg gctgtactgg ctgggctgct ggtgctagca ctgctggtgc 3200 tgctcctgtg gaagatggga ttcttcaaac. gggcga,sgca ccccgaggcc 3250 accgtgcccc agtaccatgc ggtgaagatt. cctc;gggaag accgacagca 3300 gttcaaggag gagaagacgg gcaccatcct gaggaacaac tggggcagcc 3350 cccggcggga gggcccggat gcacacccc:a tcc~gcctgc: t.gacaggcat 3400 cccgagctgg gccccgatgg gcar_ccaggg ccaggcaccg cctaggttcc 3450 catgtcccag cctggcctgt ggctgccct.c catcccttcc ccagagatgg 3500 ctccttggga tgaagagggta agagtggg:~t gctggtgtcg catcaagatt 3550 tggcaggatc ggcttcctca ggggcacaga cctctcccac ccacaagaac 3600 tcctcccacc caacttcccc ttagagtgct gtgagatgag agtgggtaaa 3650 tcagggacag ggccatgggg tagggtgaga agggcagggg tgtcctgatg 3700 caaaggtggg gagaagggat cctaatcoct tc~~tc:tccca ttcacccLgt 3750 gtaacaggac cccaaggacc tg~~ctccc-:cg gaagt_gcctt aacctaga_qg 3800 gtcggggagg aggttgtgtc actgactcag gctgc,tcctt ctctagtttc 3850 ccctctcatc tgaccttagt ttgctgc<~at cagt~tagtg gtttcgtggt 3900 ttcgtctatt tattaaaaaa tatt.tgagaa caaaaaaaaa aaaaaaaaaa 3950 a 3951 <210> 437 <2i1> 1191 <212> PRT
<213> Homo sapiens <400> 437 Met Ala Gly Ala Arg Ser Arg Asp Pro Trp Gly Ala Ser Gly Ile Cys Tyr Leu Phe Gly Ser Leu Leu Val Glu Leu Leu Phe Ser Arg Ala Val. Ala Phe Asn Leu Asp Val Met Gly Ala Leu Arg Lys Glu Gly Glu Pro Gly Ser Leu Phe Gly I~he Ser ~~'al Ala Leu His Arg G1n Leu Gln Pro Arg Pro Gln Ser Trp Leu Leu Val Giy Ala Pro Gln Ala Leu Ala Leu Pro Giy Gln Gln A-i.a Asn Arg Thr Gly Gly Leu Phe Ala Cys Pro Leu Ser Leu Glu Glu Thr Asp Cys Tyr Arg 95 100 1.05 Val Asp Ile Asp Gln Gly Ala Asp Met Gln Lys Glu Ser Lys Glu Asn Gln Trp Leu Gly Val Ser Val Arg ier Gln Gly Prc Gly Gly Lys Ile Val Thr Cys Ala His Arg T'yr Glu Ala Arg Gln Arg Val 140 145. 150 Asp Gln Ile Leu Glu Thr Arg As~~ Met Ile Gly Arg Cys Phe Val Leu Ser Gln Asp Leu Ala I1e Arg Asp Glu Leu Asp Gly Gly Glu 170 17~ 180 Trp Lys Phe Cys Glu Gly Arc Pry G1n Gly His Glu Gln Phe Gly Phe Cys Gln Gln Gly Thr Ala Ala Aia Phe Ser Pro Asp Ser His Tyr Leu Leu Phe Gly Ala Pro Gly Thr Tyr Asn Trp Lys Gly Thr 215 2<t0 225 Ala Arg Va1 Glu Leu Cys Ala G'~n Gly Ser Ala Asp Leu Ala His Leu Asp Asp Gly Fro Tyr Glu A1a Gly Gly Glu Lys Glu Gln Asp Pro Arg Leu Ile Pro Val Pr_o Ala Asn Ser Tyr Phe Gly Phe Ser I1e Asp Ser Gly Lys Gly Leu Val Arg Ala Glu Glu Leu Ser Phe 275 .%8C) 285 Val Ala Gly Ala Pro Arg Ala Asn His Lys Gly Ala Val Val Ile 290 ~'95 300 Leu Arg Lys Asp Ser Ala Ser Arg Leu Val Pro Glu Val Met Leu 305 31.0 315 Ser Gly Glu Arg Leu Thr Ser Gly Phe Gly Tyr Ser Leu Ala Val Ala Asp Leu Asn Ser Asp Gly Trp Pro Asp Leu Ile Val Gly Ala Pro Tyr Phe Phe Glu Arg Gln G:Lu Glu Leu Gly Gly Ala Val Tyr 350 35.5 360 Val Tyr Leu Asn Gln Gly Gly His Trp Ala C~ly Ile Ser Pro Leu 36'.p 370 375 Arg Leu Cys Gly Ser Pro AsF Ser Met Fhe ~.~ly Ile Ser Leu Ala Val Leu Gly Asp Leu Asn Glrv Asp Gly Fhe Fro Asp Ile A1a Val Gly Ala Pro Fhe Asp Gly Asp Gly Lys Val Phe Iie Tyr His Gly Ser Ser Leu Gly Val Val Ala Lys Pro Ser Gln Val Leu Glu Gly Glu Ala Val GIy Ile Lys Ser Phe Gly Tyr Ser Leu Ser Gly Ser Leu Asp Met Asp Gly Asn Gin Tyr Pro Asp Leu heu Val Gly Ser 455 46C 96'i Leu Ala Asp Thr Ala Val Leu Phe Arg Ala Arg F?ro Ile Leu His 470 975 4$0 Val Ser His Glu Vai Ser Ile Ala Pro Arg Ser Ile Asp Leu Glu Gln Pro Asn Cys Ala Gly C;ly His Ser Val Cys Val Asp Leu Arg Val Cys Phe Ser Tyr Ile Ala Val Pro Ser Ser 'I'yr Ser Pro Thr 51.5 52 0 525 Val Ala Leu Asp Tyr Val Leu Asp Ala Asp Thr Asp Arg Arg Leu Arg Gly Gln Val Pro Arg Val Thr Phe L~2u Ser Arg Asn Leu Glu Glu Pro Lys His Gln Ala Ser Gl.y 'I'hr Val Trp Leu Lys His Gln His Asp Arg Val Cys Gly Asp Ala Met Fhe Gln Leu Gln Glu Asn Val Lys Asp Lys Leu Arg A1a ~le Val Va7. Thr Leu Ser Tyr Ser Leu Gln Thr Pro Arg Leu P.rg Arg Gl.n Ala Pro Gly Gln Gly Leu Fro Pro Val Ala Pro Ile Leu Asn A:La His Gln Pro Ser Thr Gln Arg Ala Glu Ile His Phe Leu Lys Gln Gly Cys G1y Glu Asp Lys I1e Cys Gin Ser Asn Leu Gln Leu Val His P.la ArG Phe Cys Thr Arg Val Ser Asp Thr Glu Phe Gln Fro Leu Prcu MeC Asp Val Asp Gly Thr Thr Ala Leu Phe Ala Leu per Gly Gln Prn Va1 Ile Gly 680 685 b90 Leu Glu Leu Met Val 'rhr Asn heu e'ro Ser Asp Pro Ala Gln Pro Gln Ala Asp G1y Asp Asp Ala His Glu ALa Gln Leu Leu Val Met Leu Pro Asp Ser Leu His Tyr Ser Gly Val Arg A:La Leu Asp Pro Ala Glu Lys Pro Leu Cys Leu Ser Asn Glu Asn Ala Ser His Val Glu Cys Glu Leu Gly Asn Pro Met Lys Arg Gly Ala Gln ~'al Thr 755 760 76_'.
Fhe Tyr Leu Ile Leu Ser Thr Ser Gl.y Ile: Ser Ile Glu Thr Thr Giu Leu Glu Val Glu Leu Leu Lei Ala Thr Ile :3er Glu Gln Glu Leu His Pro Val Ser Ala Arg Ala Arg Val Phe Ile Glu Leu Pro Leu Ser Ile Ala Gly Met hla Ile Pro Gln Gin Leu Phe Phe Ser Gly Val Val Arg Gly G1u Arg Ala Met Gln Ser Glu Arg Asp Val Gly Ser Lys Val Lys Tyr Glu Val Thr Val Ser Asn Gln Gly Gl.n 895 8~0 855 Ser Leu Arg Thr Leu Gly Ser Ala Phe Leu Asn Iie Met Trp Pro His Glu Ile Ala Asn Gly LVS Trp Leu Leu Tyr Pre Me!. Gln Val Glu Leu Glu Gly Gly Gln G1y Fro Gly Gln Ly.s Gly Leu Cys Ser 8901 f395 900 Pro Arg Pro Asn Ile Leu Hi.s i~eu Asp 'Jal Asp Ser Arg Asp Arg Arg Arg Arg Glu Lea Glu Pro Pro G:lu <>ln Gln Glu Pro Gly Glu Arg Gln Glu Pro Ser Met Ser Trp Trp Pro Val Ser Ser Ala Glu Lys Lys Lys Asn Ile Thr Leu Asp Cys Ala Arg Giy Thr Ala Asn CysValValFheSerCysPro LeuI'yrSer PheAspArgAla Ala ValLeuHisValTrpGlyArg LeuirpAsn ,perThrPheLeu Glu C~luTyrSerAlaValLysSer LeuGluVal IleValArgAla Asn IleThrValLys5erSerIle LysAsnLeu MetLeuArgAsp Ala SerThrValIleProValMet 'JalTyrL~euAspProMetAla Val ValAlaGluGlyValPrcTrp TrpValIle LeuLeuAlaVa.1 Leu AlaGlyLeuLeuValLeuAia LeuLeuVal LeuLeuLeuTrp Lys MetGlyPhePheLysArgAia Ly:HisPro GluAlaThrVal Pro 1070 107c> 1080 GlnTyrHisAlaValLysIle ProArgGlu AspArgGlnGln Phe 1085 109;) 1095 LysGluGluLysThrGlyThr IleLeuArg AsnAsnTrpGly Ser PreArgArgGluGlyProlispAnaHisPro Il.eLeuAlaAla Asp 7.115 110 1125 GlyHisProGluLeuGlyPro A:pGlyHis ProGlyProGly Thr 11:30 l 1140 1~j5 Ala <210> 438 <211> 24 <212> DNA
<213> Artificial.
<220>
<221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <400> 438 ggctgacacc gcagtgctct tcag 24 <210> 439 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-29 <223> Artificial Sequence <900> 439 gctgctgggg act.gcaatgt agct 24 <210> 440 <211> 46 .212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-46 <22?> Artificial Sequence <400> 440 catcctccat gtctcccatg aggtctctae: tgctcc<3cga agcatc 46 <210> 941 <211> 1964 <212> DNA
<=.213> Homo sapiens <400> 441 cgcgccgggc gcagggagct gagtggacgg ctcgagacgg cggcgcgtgc 50 agcagctcca gaaagcagcg agttggcaga gcagggctgc atttccagca 100 ggagctgcga gcacagtgct. ggctcacaac aagatgctca aggtgtcagc 150 cgtactgtgt gtgtgtgcag ccqcttggtg cagtcagtct ctcgcagctg 200 ccgcggcggt ggctgcagcc ggggggcggt cggacggcgg taattttc:tg 250 gat:gataaac aatggctcac ca<:aatctct cagtatgaca aggaagtcgg 300 acagtggaac aaattccgag acgaagt«ga ggatgattat ttcc:gcactt 350 ggagtccagg aaaaccctt:c gatcagg~at: taga~ccagc taaggatcca 400 tgcttaaaga t_qaaatgtag tcgccataaa gtatgcattg ctcaagattc 450 tcagactgca gtctgcatta gtcaccggag gcttaca<:ac aggatgaaag S00 aagcaggagt agaccatagg cagtggaggg gtcc:catatt atccacctgc 550 aagcagtgcc cagtggtc:ta tcccagc:cct gttt:gtggtt cagatggtca 600 tacctactct tttcagtgca aactagaata tca<xgcatgt gtcttaggaa 650 aacagatctc agtcaaatgt gaaggac;att acc~atgtcc ttcagataag 700 cccaccagta caagcagaaa tgttaagaga gcatgcagtg acctggagtt 750 cagggaagtg gcaaacagat tgcgggactg gttcaaggcc cttcat~gaaa 800 gtggaagtca aaacaagaag acaaaaacat tgctgaggcc taagagaagc 850 agattcgata ccagcat.ctt gccaatttgc aaggactcac ttggctggat 900 gtttaacaga cttgatacaa actatgacct gctattggac cagtcagagc 950 tcagaagcat ttaccttgat aagaatgaac agtgtaccaa ggcattcttc 1000 aattcttgtg acacatacaa ggacagtita atatctaata atgagtggtg 1050 ctactgcttc cagagacagc aagac<:cacc ttgc:cag~.ct gagctcagca 1100 atattcagaa gcggcaaggg gtaaayaagc tc<:taggaca gtatat:cccc 1150 ctgtgtgatg aagatggtta caacaagcca acacaatgtc atggcagtgt 1200 tggacagtgc tggtgtgttg acagatatgg aaatc7aagtc atgggatcca 1250 gaataaatgg tgttgcagat tgtgcaatag attttgagat ctccggagat. 1300 tttgctagtg gcgattttca tgaatgcxact gatgatc,agg atgatgaaga 1350 cgatattatg aatgatgaag atgaaattga agatgat:gat gaagatgaag 1400 gggatgatga t:gatggtggt gatgaccat<3 atgt:at<~cat ttgattgatg 1450 acagttgaaa tcaataaatt ctacatttct aatatttaca aaaatgatag 1500 cctatttaaa attatcttct tccccaataa caaaatgatt ctaaacctca 1550 catatatttt gt.ataattat ttgaaaaatt gcagctaaag t:tatagaact 1600 ttatgtttaa ataagaatca ttt.gcttt<.:a gttttt:atat tccttaca~~a 1650 aaaagaaaat acatatgcag tctagtcaya caaaa':aaag ttttgaagtg 1700 ctactataat aaatttttca cgagaacaaa ctt.tgtaaat cttccataag 1750 caaaatgaca gctagtgctt gggat:cgtac atgttaatt.t tttgaaagat 1800 aattctaagt gaaat.ttaaa ataaa taaat ttttaatgac ctgqgtcT_ta 1850 aggatttagg aaaaatatgc atgctttaat tgcat:ttcca aagtagcatc 1900 ttgctagacc tagatgagt:c aggataa~:ag agagatacca catgactcca 1950 aaaaaaaaaa aaaa 1964 <210> 442 <211> 936 <2i2> PRT
<213> Homo sapiens <400> 442 Met Leu Lys Val Ser Ala Val ~~eu Cys Val Cys Ala Ala Aia Trp Cys Ser Gln Ser Leu Ala fila Ala A1a Ala Val Ala Ala AIa Gly Gly Arg Ser Asp Gly Gly Asn Phe Leu Asp Asp Lys Gin Trp Leu Thr Thr Ile 5er Gln Tyr Asp Lys Glu Val Gly G'yn Trp Asn Lys 50 'a5 60 Phe Arg Asp Glu Val Glu Asp Asp T'yr Phe Arg Thr Trp Ser Pro Gl.y Lys Pro Fhe Asp Gln Ala Leu Asp Pro Ala Lys Asp Pro Cys Leu Lys Met Lys Cys Ser Arg His Ly;> Val C:ys Ile Ala Gln Asp Ser Gln Thr Ala Val Cys Iie Ser His Arg llrg Leu Thr His Arg 110 11.5 1.20 Met Lys Glu Ala Gly Val. Asp His Arg Gl.n Trp Arg Gly Pro Tle Leu Ser Thr Cys Lys Gln Cys Pro Val Val Tyr Fro Ser Pro Val 140 1~5 150 Cys Gly Ser Asp Gly His Thr 'ryr Ser Phe Gln Cys Lys Leu G1u Tyr Gln Ala Cys Val Leu Gly Lys Glu Ile Ser Val Lys Cys Glu G1y His Cys Pro Cys Pro Ser Asp Lys Pro Thr Ser Thr Ser Arg Asn Val Lys Arg Ala Cys Ser Asp Leo Glu Phe Arg Glu Val Ala Asn Arg Leu Arg Asp Trp Phe Ly: Ala Leu His Glu Ser Gly Se:r Gln Asn Lys Lys Thr Lys Thr Leu Leu Arg Pro Glu Arg Ser Arg Phe Asp Thr Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Phe Asn Arg Leu Asp 'Phr An Tyr Asp Leu Leu Leu Asp Gln 260 265 2'70 Ser Glu Leu Arg Ser Ile Tyr Leu Asp Lys Asn Glu Gln Cys Thr Lys Ala Phe Phe Asn Ser Cys Asp Thr Tyr Lys Asp Ser Leu I1e Ser Asn Asn Glu Trp Cys Tyr C:ys Phe Gln Arg Gln Gln Asp Pro 305 a10 315 Pro Cys Gln Thr C>1u Leu Ser Asn Ile c;ln Lys Arg Gln Gly Val Lys Lys Leu Leu Gly Gln Tyr Ile Pro Leu Cys Asp Glu Asp Gly Tyr Tyr Lys Pro Thr Gln Cys Hi.s Gly Ser Val Gly Gin Cys Trp Cys Val Asp Arg Tyr Gly .Asn Glu Val Met G:Ly Ser Arg Ile Asn Gly Val Ala Asp Cys Ala Ile Asp Phe Glu Ile Ser Gly Asp Phe Ala Ser Gly Asp Phe His Glu Trp 'rhr Asp Asp Glu Asp Asp Glu Asp Asp Ile Met Asn Asp Glu Asp Glu Ile Glu Asp Asp Asp Glu Asp Glu Gly Asp Asp Asp Asp Gly Gly Asp Asp His Asp Jal Tyr Tle <210> 443 <211> 25 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-25 <223> Artificial Sequence <400> 443 cagcaatatt cagaagcggc aaggg 25 <210> 449 <211> 28 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> ~-28 <223> Artificial Sequence <400> 449 catcatggtc atcaccacc:a tcatcatc: 28 <210> 44' <211> 98 <212> DNA
<213> Artificial <220>
<22i> Artific.iai Sequence <222> 1-48 <223> Artificial Sequence <400> 945 ggt.tactaca agccaacaca atgtcatggc agtgttggac agtgctgg 48 <210> 446 <211> 361'l <212> DNA
<213> Homo sapiens <400> 946 cagactccag atttccctgt caaccacgag gagtccagag aggaaacgcg 50 gagcggagac aacagtacct gacgcctctt. tcagcccggg atcgccccag 100 cagggatggg cgacaagatc tggctgccct tccccgtgct ccttctggcc 150 gctctgcctc cggtgctgct gcctggggcg gccggctt:ca caccatccct 200 cgatagcgac ttcaccttta cccttcccgc cggccagaag gagtgcttct 250 accagcccat gcccctgaag gcctcgctgg agatcgagta ccaagtt:tta 300 gatggagcag gattagatat t:gatttccat ct.tgcctctc cagaaggcaa 350 aaccttagtt tttgaacaaa gaaaatcaga tggagttrac actgtagaga 400 ctgaagttgg tgattacatg ttctactttg acaat:acatt cagcaccatt: 450 tctgagaagg tgattttctt tgaatta atc ctggataata tgggagaaca 500 ggcacaagaa caagaagatt ggaagaaata tattact:ggc acagatat_ar- 550 tggatatgaa actggaagac atcctggaar ccatcaacag catcaagtcc 600 agactaagca aaagtgggca catacaaatt ctgcttagag catttgaagc 650 tcgtgatcga aacatacaag aaagcaactt: tgat~agagtc aatttctggt 700 ctatggttaa tttagtggtc atggtggtc,g tgtcagcr:at tcaagtttat 750 atgctgaaga gtctgtttga agataa gaqg aaaagt:agaa cttaaaactc 800 caaactagag tacgtaacat_ tgaaaaatcaa qgc;atasaaaa tgcaataaac 850 tgttacagtc aagaccatta atggtcttct ccaaaatatt ttgagatata 900 aaagtaggaa acaggtataa ttttaatgtg aaaattaagt cttcactttc 950 tgtgcaagta atcct.gctga tcc;agttgta ct-.aagtgtg taacaggaat 1000 attttgcaga atataggttt aactgaatga agcc<3tatta ataactgcat 1050 tttcctaact ttgaaaaat:t. ttgcaaa~.gt cttag gtgat ttaaataaat 1100 gagtattggg cctaattgca acaccagr_ct gtttttaaca ggttctatta 1150 cccagaactt ttttgtaaat gcggcagtta c<aaattaact gtggaagttt 1200 tcagttttaa gttataaatc acct:gagaat to ccaaatga tggattgaat 1250 aaatctttag actacaaaag ccc,sactttt ctctatttac atatgcatct 1300 ctcctataat gtaaat:agaa taatagctt:t gaaatacaat taggtttttg 1350 agatttttat aaccaaatac atttcagtgt uacatattag cagaaagcat 1900 tagtcttt.gt actttgctta cattcccaaa <igctgacatt ttcacgattc 1950 ttaaaaacac aaagttacac t.tactaaaat tac,gacatgt tttctctttg 1500 aaatgaagaa tat:agtttaa aag ctt.cctc ctccataggg acacattttc 1550 tctaaccctt aactaaagtg taggat.ttta aaatt:aaatg tgaggtaaaa 1600 taagtttatt tttaatagta tctgtcaagt taatatctgt caacagttaa 1650 taatcatgtt atgttaattt taacatgatt gctgacttgg ataattcatt 1700 attaccagca gttatgaagg aaatattgct aGaatgatct gggcctacca 1750 taaataaata tctccttttc tgagc.tctaa gaattatcag aaaacaggaa 1800 agaatttaga aaaacttgag aaaac:ctaat cc~aaaataaa attcacttaa 1850 gtagaactat aaataaatat ctagaatctg actggctcat catgacatcc 1900 t:actcataac at:aaatcaaa ggagatgatt aattt:cc,sgt tagctggaag 1950 aaactttggc tgtaggtttt tattttc:tac aagaattctg gtttgaatta 2000 tttttgtaag caggtacatt ttataaaatg taagccctac tqtaaggttt: 2050 agcactgggt qtacatattt attaaaaatt tttattataa caacttttat. 2100 taaaatggcc t.ttctgaaca ctttatttat tgatgtt:gaa gtaaggatta 2150 gaaacataga ctcccaagtt ttaaacacct aaatgtgaat aacccat.ata 2200 tacaacaaag tttcagccat ctagcttttt gaagtctatg ggggtcttac 2250 tcaagtacta gtaatttaac ttcatc-atga atgaactata atttttaagt 2300 tatgcccatt tataacgttg tttatgacta cattgt.gagt tagaaacaaa 2350 cttaaaattt ggggtataga accc:ctcaac aggttagtaa tgctggaatt 2400 cttgatgagc aataatgata accagaga~yt gat:tt~:attt acactcatag 2950 tagtataaaa agagatacat ttccca ct~~a ggc:ccctggg agaagagcag 2500 cttagatttc cctactggca aggtttttaa aaatgaggta aatgccgt.at 25_'0 atgatcaatt accttaattg gcc:aagaaaa tgctt.caggt gtctaggggt 2600 atcctctgca acacttgcag aacaaag<tc aataagatcc ttgcctatga 2650 atacccctcc cttttgcgct gttaaatttg caatgagaag caaatttaca 2700 gtaccataac taataaagca gggt.acagat at:aaactact gcatcttttc 2750 tataaaactg tgattaagaa ttct:acctct cctgtatggc tgttactgta 2800 ctgtactctc tgactcctta cctaacaatg aatttgttac ataatcttct 2850 acatgtatga tttgtgcc:ac tgatcttaaa cct<3tgattc agtaacttct 2900 taccatataa aaacgataat tgctttatt,' ggaaaagaat ttaggaatac 2950 taaggacaat tatttttat.a aacaaagtaa aaagacagat atttaagagg 3000 cataaccaaa aaagcaaaac t.tgtaaacag <~gtaaaaatc tttaat_attt 3050 ctaaagacat actgtttatc tgcttcatat gcttttttt:a atttcactat 3100 tccatttcta aattaaagtt atgctaaat.t gagtaagctg tttatcactt 3150 aacagctcat tttgtctttt tcaatatac a aav.tttaaaa atactacaat 3200 atttaactaa ggcccaa ccg atttccataa tgtagcagtt accgtgttca 3250 cctcacacta aggcctagag tttgctctga tatgcatttg gat:gattaat 3300 gttatgctgt tctttcatgt gaatgtcaag ac:atggaggg tgtttgtaat 3350 tttatggtaa aattaatcct tcttacacat aatggtgtct taaaattgac 3400 aaaaaatgag cacttacaat tgtatgtctc ctcaaatgaa gattctttat 3950 gtgaaatttt aaaagacatt gattc~:g::at gtaaggattt ttcatctgaa 3500 gtacaataat gcacaatcag tgttgctcaa actgcttv.at acttataaac 3550 agccatctta aataagcaa~: gtattgtgag t,actc(atatg tatataataa 3600 aaattatcaa aggaaaa 3617 <210> 447 <217> 229 <212> PRT
<213> Homo sapiens <400> 447 Met Gly Asp Lys Ile Trp Leu Pra Phe Pro Val. Leu Leu L,eu Ala Ala Leu Pro Pro Val Leu Leu Pre Gly Ala Ala Gly Phe ~'hr Pro 20 2~. 30 Ser Leu Asp Ser Asp Phe Th r Phe Thr Leu Pro Ala Gly Gin Lys Glu Cys Phe Tyr Gln I?ro Met Pr;,Leu Lys Ala Ser Leu Glu Ile Glu Tyr Gln Val Leu Asp Gly Ala Gly Leu Asp Ile Asp Phe His Leu Ala Ser Pro Glu Gly Lys Thr Leu Val Phe Glu Gln Arg Lys Ser Asp Gly Val H=s Thr Val Glu Thr G:L.u Val Gly Asp Tyr Met Phe Cys Phe Asp Asn Thr Phe Ser Thr Ile Ser Glu Lys Val Ile 110 11 '. 120 Phe Phe Glu Leu Ile Leu Asp Asn Met Gly Glu Gln Alm Gln Glu 125 7.30 135 Gln Glu Asp Trp Lys Lys Tyr Ile Thr Gly Thr Asp Ile heu Asp Met Lys Leu Glu Asp Ile I_~eu ~~lu Ser Ile Asn Ser Ile hys Ser Arg Leu Ser Lys Ser Gls.~ flis Ile Gln Ile Leu Leu Arg Ala Phe Glu Ala Arg Asp Arg Asn Ile Gln Glu Ser Asn Phe Asp Arg Val Asn Phe Trp Ser Met Val Asn Leu Val Val Met Val Val Val Ser Ala Ile Gln Val Tyr Met Leu Lys Ser Leu Phe Glu Asp Lys Arg Lys Ser Arg Thr <210> 448 <211> 23 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-23 <223> Artificial Sequence <400> 498 cccagcaggg ctgggcgaca aga 23 <210> 499 <:211> 2 3 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-23 <223> Artificial Sequence <400> 949 gtcttcc:.agt ttcatatcca ata 23 <210> 450 <211> 93 <212> DNA
<213> Artifi-cial <220>
<221> Artificial Sequence <222> 1-43 <223> Artificial Sequence <400> 450 ccagaaggag cacggggaag ggcagcc:aga tcttgtcgcc: cat 43 <210> 451 <21I> 859 <'~ 12 > DNA
<213> Home sapiens <400> 451 ccatccctga gatcttttta taaaaaaccc <~gtctttgct gaccagacaa 50 agcataccag atctcaccag agagtc:gcag acactatgc:t gcctcccatg 100 gccctgccca gtgtgtcctg gatgctgctt tcc:tgcctca ttctcctgtg 150 tcaggttcaa ggtgaagaaa cccagaagga act.gccctct ccacggatca 200 gctgtcccaa aggctccaag gcctatggct ccccctgcta tgccttgttt 250 ttgtcaccaa aatcctggat ggatgcagat ctggcttgcc agaagcggcc 300 ctctggaaaa ctggtgtctg tgctcagtgg ggctgaggga tccttecgtgt 350 cctccct.ggt gaggagcatt agtaacagct acacatacat ctggattggg 400 ctccatgacc ccacacaggg ctctgagcct g<~tggagatg gatgggagtg 450 gagtagcact gatgtgatga attactttgc atgggag.jaa aat.ccctcca 500 ccatcttaaa ccctggccac tgtgggGgcc tgtcaagaag cacaggattt 550 ctgaagtgga aagattataa ctgtgat:gca aagt:r_accct atgtctgca<~ 600 gttcaaggac t.agggcagGt gggaag=cag cagcctc:agc ttggcgtgca 650 gctcatcatg gacatgagac cagtgtgaacr actcaccctg gaagagaata 700 ttctccccaa actgccctac ctgactacct_ tgtcat~~atc ctccttcttt 750 ttccttt.ttc ttcaccttca t.ttcaggctt ttctctgtct tccatgtcit. 800 gagatctcag agaataataa taaaaatgtt actttataaa aaaaaaaaaa 850 aaaaaaaaa 859 <21 0> 452 <211> 175 <212> PRT
<213> Homo sapi.ens <900> 452 Met Leu Pro Pro Met Ala Leu E'ro Ser Val Ser Trp Met Leu Leu Ser Cys Leu Ile Leu Leu ~~ys Gin Val Gl.n Gly Glu Glu Thr Gln c: 0 a' S 3 0 Lys Glu Leu Pro Ser Pro Arg I.e Ser Cys Pro Lys Gly Ser Lys Ala Tyr Giy Ser Pro Cys Tyr Ala Leu Phe Leu Ser Pre: Lys Ser Trp Met Asp Ala Asp Leu Ala Cys Gln hys Arg Pro Ser Gly Lys 65 7C. 75 Leu Val Ser Val Leu Ser Gly Ala Glu (~ly Ser Phe Val Ser Ser 8(r 85 90 Leu Val Arg Ser Ile Ser Asn Ser Tyr Ser Tyr Ile Trp Ile Gly Leu His Asp Pro Thr Gln Gly Ser G:Lu Pro Asp Gly Asp Gly Trp Glu Trp Ser Ser Thr Asp 'Jal Met Asn Tyr Phe Ala Trp Glu Lys lay 130 135 Asn Pro Ser Thr Iie Leu Asn Pro Gly His Cys Gly Ser Leu Ser Arg Ser Thr Gly Phe Leu Lys Trp l.,ys Asp Tyr Asn C',ys Asp Ala Lys Leu Pro Tyr Val Cys Ly:- Phe Lys Asp 170 i75 <210> 453 <211> 5 50 <212> DNA
<213> Homo sapiens <400> 453 ccagtctgtc gccacctcac ttggtgtctg ctgtccccgc caggcaagcc 50 tggggtgaga gcacagagga cxtgggccggg accatgcggg ggacgcggct 100 ggcgctcctg gcgctggtgc tggctgcctg cggagagctg gcgccggccc 150 tgcgctgcta cgtctgtccg gagcccacag gagtgtcgga ct.gtgt:cacc: 200 atcgccacct gcaccaccaa cgaaac~~atc; tgcaagacca cactctactc 250 ccgggagata gtgtacccct tccaggggg« ctccacggtg accaagtcct 300 gtgccagcaa gtgtaagccc tcggatgtgr3 atggcatcgg ccagaccctg 350 cccgtgtcct gctgcaatac tgagctgtgc aatgtagacg gggcgcccgc 900 tctgaacagc ctccactgcg gggccctcac gctcctccca ctcttgagc;c 950 tccgactgta gagtccccgc ccacccccat ggccct:atgc ggcccagccc 500 cgaatgcctt gaagaagtgc cccctgcai:c aggaaaaaaa aaaaaaaaaa 550 <210> 459 <2i1> 125 <212> PRT
<213> Homo Sapiens <400> 459 Met Arg Gly Thr Arg Leu Ala Lc=a Leu Ala Leu Val Leu Ala Ala Cys Gly Glu Leu Ala Fro Ala Leu Arch Cys Tyr Val Cys Pro Glu 20 a5 30 Pro Thr Gly Val Ser Asp Cys Val Thr I1e Ala Thr Cys Thr Thr Asn Glu Thr Met Cys Lys Thr Thr Leu Tyr Ser Arg Glu Ile Val 50 5°, 60 Tyr Pro Fhe Gln Gly Asp Ser 'Thr Val '1'hr Lys Ser Cys Ala Ser Lys Cys Lys Pro S2r Asp Val Asp Gly Ile Gly Gln Thr Leu Pro Val Ser Cys Cys Asn Thr Glu Leu Cys Asn Val Asp Gly Ala Pro Ala Leu Asn Ser Leu His Cys Gly Ala Leu Thr Leu Leu Pro Leu Leu Ser Leu Arg Leu <210> 455 <211> 1518 <212> DNA
<213> Homo Sapiens <400> 455 ctgcagtcag gactctggga ccgcaggggg ctcccggacc ctgactctgc 'i0 agccgaaccg gcacggtttc gtggggaccc aggcttgcaa agtgacggtc i00 attttctctt tctttctccc. t:.cttgagtcc ttc:tgag,3tg atggctctgg :L50 gcgcagcggg agctacccgg gtctttGtcg cgatggtagc ggcggctctc: 200 ggcggccacc ctctgctggg agtgagc:gcc accttgaact cggttctcaa 250 ttccaacgct atcaagaacc tgcccccacc gctgggc:ggc gctgcggggc 300 acccaggctc tgcagtcagc gccgcgccgg gaatcct:gta cc cgggcggg 350 aataagtacc agaccattga caactaccag ccgt:aci:cgt gcgcagagga 400 cgaggagtgc ggcactgatg agtactgcgc tagt:cccacc cgcggagggg 950 acgcaggcgt gcaaatctgt ctcgcctgca ggaagcgccg aaaacgctgc 500 atgcgtcacg ctatgtgctg ccccgggaat tactgcaaaa atggaatatg 550 tgtgtcttct gatcaaaatc attrc~cgayg agaaat_tgag gaaaccat~ca 600 ctgaaagctt tggtaatgat catagcacc-t t.ggatcxggta ttccagaaga 650 accaccttgt cttcaaaaat. gtatcacac~c aaaggacaag aaggttctgt 700 ttgtctccgg tcatcagact gtgcctcagg attgtgttgt gctagacact 750 tctggtccaa gatctgtaaa cct:gtcctga aagaaggtca agtgtgtacc 800 aagcatagga gaaaaggctc tcatggacta gaaat:attcc agcgttgtta 850 ctgtggagaa ggtctgt.ct.t gccggataca gaaagatcac c atcaagcca 900 gtaattcttc taggcttcac acttgtc,~ga gacawtaaac cagctatcca 950 aatgcagtga actcctttta tataatagat gca atgaaaa ccttttatga 1000 ccttcatcaa ctcaatccta aggatataca agttctgtgg tttcagttaa 1050 gcattccaat aacaccttcc aaaaacctgg agtc,taagag ctttgtttct 1100 ttatggaact cccctgtgat tgcagtaaat tact:gtattg taaattctca 1150 gtgtggcact tacctgtaaa tgcaatgaaa rtt.~:taatta tttttctaaa 1200 ggtgctgcac tgcctatttt tcctcttgtt atgtaaattt ttgt.acacat 1250 tgattgttat cttgactgac aaatattcta tattgaactg aagtaaatca 1300 tttcagctta tagttcttaa aagcataacc ctttacccc:a tttaattcta 1350 gagtctagaa cgcaaggatc t,cttggaat.g acaaatgata ggtacctaaa 1400 atgtaacatg aaaatactag cttatt.ttc:t gaa~atgtact atcttaatgc 1450 ttaaattata tttcccttta ggctgtgata gtttttgaaa taaaatttaa 1500 catttaaaaa aaaaaaaa 151E

<:210> 456 <211> 266 <212> PRT
<213> Homo Sapiens <900> 456 Met Met A1a Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro Gly Ile Leu Tyr Pro (~ly Gly Asn hys Tyr Gln Thr Ile Asp Asn Tyr Gln Pro Tyr Pro wya Ala Gl.u Asp Glu Glu 80 8'9C
Cys Gly Thr Asp Glu Tyr Cys Ala Ser Pr~_~ Thr Arg Gly Gly Asp 95 10~ 105 Ala Gly Va1 Gln Ile Cys LeLn Ala Cys: Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp G1n Asn H_s Phe Arg Gly <~lu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser Lys Met. Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys heu Arg Ser Ser Asp C:ys Ala Ser Gly Leu Cys Cys Ala llrg His 1?he Trp Ser Lys Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Vr:l Cys Thr Lys His Arg Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser 2_95 250 255 Asn Ser Ser Arg Leu His Thr Cys Gln Arg His <210> 457 <211> 638 <212> DNA
<213> Homo sapiens <220>
<221> unsure <222> 30, 123, 133, 139, 180, 214, 259, 282, 308, 452, 46'1, 471, 473, 509, 556 <223> unknown base <400> 45'?
tgtgtttccc tgcagtcaga atttgggacr gcaggggttc ccggac:ctga 50 ttttgcagcg gaacgggaag gttttgtggc; ac:ccaggttg aaatgacggt 100 catttttttt tctttctcct tcng:aagtccv t.tntgag ang atggttttgg 150 gcgcagcggg agctaacccg gttttttgtn gcgatggtag cggcggtttt 200 cggcggccac cttntgctgg gagtgagcgc ca<~cttgaat cggttttcaa 250 ttccaacgnt atcaagaacc tgc<.:cc:cacc gntgggcggc gctgcggg<~c 300 acccaggntt tgcagtcagc gccgcgccgg gaatcc:tgta cccgggcggg 350 aataagtacc agaccattga caattaccag c.cgtac ccgt gcgcagagga 400 cgaggagtgc ggcactgatg agtactgc~3c tagtcc:cacc cgcggagggg 450 angcgggcgt gcaaatntgt ntngcctgca ggaagcgccg aaaacgctgc 500 atgcgtcang ctatgtgctg ccccgggaat tactgcaaaa atggaat<ctg 550 tgtgtnttct gatcaaaatc atttccgagg agaaattgag gaaaccatca 600 ctgaaagctt tggtaatgat catagcacct tggat:ggg E38 <210> 958 <211> 9040 <212> DNA
<213> Homo Sapiens <900> 458 gaggaaccta ccggtaccgg ccgcgcgctg gtagtcgccg gtgtggctgc 50 acctcaccaa tcccgtgegc cgcggctggg ccgt:cggaga gtcxcgtgtgc 100 ttctctcctg cacgcggtgc ttgggctcgg ccac~gcgggg tccgccgcca 150 gggtttgagg atgggggagt agctacagga agcgaccccg cgatggcaag 200 gtatattttt gtggaatgaa aaggaagtat tagaaatgag ctgaagacca 250 ttcacagatt. aatatttttg <~ggacagatt tgtgatgctt gattcaccct 300 tgaagtaatg tagacagaag tt~~tcaaat:t tgc:atattac atcaactgga 350 accagcagtg aatcttaatg ttcact:taaa tc<igaacttg cataagaaag 400 agaatgggag tctggttaaa taaagatgac tatatcagag acttgaaaag 450 gatcar_tctc tgttttctga tagtgtatat ggccatttta gtgggcacag 500 atcaggattt ttacagttta cttggagtgt ccaaaactgc aagcagtaga 550 gaaataagac aagctttcaa gaaattggca ttgaagt~ac atcctgataa 600 aaacccgaat aacccaaatg ~:acatgccga ttttt.taaaa ataaatagag 650 catatgaagt actcaaagat gaagatctac ggaaaaagta tgacaaatat 700 ggagaaaagg gacttgagga taatraaggt gg<:cagtatg aaagctggar~ 750 ctattatcgt tatgattttg gtatttatga tgatgatcct gaaat<:ataa 800 cattggaaag aagagaattt gatgctgctc~ tt:aattc:tgg agaactgtgg 850 tttgtaaatt tttactcccc aggctottca cact.gccatg atttagctcc 900 cacatggaga gact:ttgcta aagaagtgga tgggttactt cgaattggag 950 ctgttaactg tggtgatgat agaatgcttt gccgaatgaa aggagtcaac 1000 agctatccca gtctcttcat ttttcggtct ggaatggccc cagtgaaata 1050 tcatggagac agatcaaagg agagtttagt gagttttgca atgcagcatg 1100 ttagaagtac agtgacagaa ctttggacag gaaatt.ttgt caactccata 1150 caaactgctt ttgctgctgg tattggctgg ctgatcactt tttgttcaaa 1200 aggaggagat tgtttgactt cacagacacg ac:tcaggctt agtggcatgt 1250 tgtttctcaa ctcattggat gcta,sagaaa tatat:ttgga agt.aatacat 1300 aatcttccag attttgaaca actttcggca aacacactag aggatcgttt 1350 ggctcatcat cggtggctgt tattttttca tt:ttggaaaa aatgaaaatt 1400 caaatgatcc tgagctgaaa aaaca aaaaa ctctacttaa aaatgatcat 1950 attcaagttg gcaggtttga ct.gttcctct gc:accagaca tctgtagtaa 1500 tctgtatgtt tttcagccgt c~_ctagcagt atttaaagga caaggaacca 1550 aagaatatga aattcatcat ggaaagaaga ttctatatga tatacttgcc 1600 tttgccaaag aaagtgtgaa ttctcat~gtt accacgcttg gacctcaaaa 1650 ttttcctgcc aatgacaaag aaccatggct t:gttgatttc tttgccccc:t 1700 ggtgtccacc atgtcgagct ttactaccag agttacgaag agcatcaaat 1750 cttctttatg gtcagcttaa c~tttgcrtaca ctagattgt:a cagttcatga 1800 gggactctgt aacatgt.ata acattc:aggc ttatccaaca acagtggtat 1850 tcaaccagtc caacattcat gagtat:gaag gac:atcactc tgctgaacaa 1900 atcttggagt tcatagagga tcttatgaat ccttcagtgg tctcccttac 1950 acccaccacc ttcaacgaac tagttacaca aagaaaacac aacgaagtct 2000 ggatggttga tttctattct ccgtggtgtc atccttgc:ca agtct:taatg 2050 cc~agaatgga aaagaatggc ccggacatta ac:tggactga tcaacgtggg 2100 cagtatagat tgccaacagt atcattcttt ttgtgccc:ag gaaaacgttc 2150 aaagataccc tgagataaga t:tttttcccc caaaatcaaa taaagcttat 2200 cagtatcaca gttacaatgg ttggaatagg gatgc:ttatt ccctgagaat 2250 ctggggtcta ggatttttac ctcaagtatc cacagatcta acacctcaga 2300 ctttcagtga aaaagttcta caagggaaaa atcattoggt gattgatttc 2350 tatgctcctt ggtgtggacc ttgccagaat tt.tgctccag aatttgagct 2400 cttggctagg atgattaaag gaaaagtga<.~ agctggaaaa gtagactgtc 2450 aggcttatgc tcagacatgc cagaaagctc~ ggatcagggc ctatccaact 2500 gttaagtttt atttctacga aagagc:aaag agaaatttt.c aagaagagca 2550 gataaatacc agagatgcaa aagcaatcgc tgccttaata agtgaaaa<~t 2600 tggaaactct ccgaaatcaa ggcaagagga ataaggatga acttt:gataa 2650 tgttgaagat gaagaaaaag tttaaaagaa attctgacag atgacatcag 2700 aagacaccta tttagaatgt: tacatttat:g atgggaatga atgaacatta 2750 tcttagactt gcagttgtac tgccagaat_t atca acagca ctggtgtaaa 2800 agaagggtct gcaaactttt tctgtaaagg gccggtttat aaatatttta 2850 gactttgcag gctataatat atggttcaca catgagaaca agaatagagt 2900 catcatgtat tctttgttat ttGc'_tttaa caacc:tttaa aaaatattaa 2950 aacgattctt. agctcagagc catacaaaag taggctggat tcagtccatg 3000 gaccatagat tgctgtccc:c ctcgacggac ttat~~atgtt tcaggtggct 3050 ggcttgaaca tgagtctgct gtgctatc~t.a cataaatgtc taagttgtat 3100 aaagtccact tt.cccttcac gttttttggc tgacctgaaa agaggtaact 3150 tagtttttgg tcacttgttc t<.:ctaaaaat gctatcccta accatatatt 3200 tatatttcgt tttaaaaaca cccatgatgt ggcacagtaa acaaac~~ctg 3250 ttatgctgta ttattatgag gagattcttc attgttttct ttccttctca 3300 aaggttgaaa aaatgctttt aatttttmcac agc:,gagaaa cagtgcagca 3350 gtatatgtgc acacagtaag tacacaaatt t:gagcaacag taagtgcaca 3400 aattctgtag tttgctgtat cat:ccaggaa a acctgaggg aaaaaaatta 3450 tagcaattaa ctgggcattg tagagt.atcc ta~.atatgt:t atcaagtatt 3500 tagagttcta tattt.taaag atatat:gtgt tcatgtattt tctgaaattg 3550 ctttcataga aattttccca ctgata gttg at!:tttgagg catctaatat 3600 ttacatattt gccttctgaa ctttgttttg acctgtatcc tttatt.taca 3650 ttgggttttt ctttcatagt tttggttttt cactcctgtc cagtctattt 3700 attattcaaa taggaaaaat tactttacag gttgt.tti:ac. tgtagcttat 3750 aatgatactg tagtt:attc: <?gttactagt ttactgt~::ag agggctgcct 3800 ttttcagata aatattgaca taataac:tga agttattttt ataagaaaat 3850 caagtatata aatctaggaa aggg<atcttc tagt.ttctgt gttgtttaga 3900 ctcaaagaat cacaaatttg tcagtaacat gt.agttc;tt.t agttataatt 3950 cagagtgtac agaatggtaa aaattccaat cagtcaaaag aggtcaatga 4000 attaaaaggc rtgcaacttt ttcaaaaaaa aaaaaaaaaa 9040 <210> 459 ~~211 > 747 <212> PRT
<213> I-iomo sapiens <900> 459 Met Gly Val Trp Leu Asn Lys Asia Asp Tyr Ile Arg Asp Leu Lys Arg Ile Ile Leu Cys Phe Leu Ile Val Tyr Met Ala Ile Leu Val 20 2 °~ 30 Gly Thr Asp Gln Asp Phe Tyr Ser Leu Leu Gly Val Ser Lys Thr Ala Sex Ser Arg Glu Ile Arg Gl.n Ala Pr.e Lys Lys Leu Ala Leu Lys Leu His Pro Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly 65 'i0 75 Asp Phe Leu Lys Ile Asn Arg ALa Tyr Glu Val Leu Lys Asp Glu so a5 90 Asp Leu Arg Lys Lys Tyr Asp Lys Tyr Gly Glu Lys Gly Leu Glu Asp Asn Gln Gly Gly Gln Tyr clu Ser Trp Asn Tyr 'Lyr Arg Tyr Asp Phe Gly Ile Tyr Asp Asp Asp Pro c;lu Ile I1e 'Phr Leu Glu 12'> 130 135 Arg Arg Glu Phe Asp Ala Ala 'Jal Asn Ser Gly Glu Leu Trp Phe Val Asn Phe Tyr Ser Pro Gly Cys Ser His Cys His Asp Leu Ala Pro Thr Trp Arg Asp Phe Ala Lys Glu Val Asp Gly Leu Leu Arg Ile Gly Ala Val Asn Cys Gly Asp Asp Arg Met Leu Cys Arg Met Lys Gly Val Asn Ser Tyr Pro Ser l,eu Phe Ile Phe Arg Ser Gly Met Ala Pro Val Lys Tyr His Gly Asp Arg Ser Lys Glu Ser heu Val Ser Phe Ala Mer Gln His Val Arg Ser Thr Val Thr Glu Leu Trp Thr Gly Asn Phe Val Asn Ser Ile Gln Thr Ala Fhe Ala Ala Gly Ile Gly Trp Leu Ile Thr Phe Cys Ser Lys Gly Gly Asp Cys Leu Thr Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Phe Leu Asn Ser Leu Asp Ala Lys Glu Ile Tyr l,eu Glu Val Ile His Asn Leu Pro Asp Phe Glu Leu Leu Ser Ala Asn Thr I,eu Glu Asp Arg Leu Ala His His Arg Trp Leu Leu Phe Phe His Phe Gly Lys Asn Glu Asn Ser Asn Asp Fro Glu Leu Lys Lys Leu Lys Thr Leu Leu 335 34~ 395 Lys Asn Asp His Ile Gln Val Gly Arq_ Phe Asp Cys Ser 5er Ala Pro Asp Ile Cys Ser Asn Leu Tyr Val Phe Gln Pro Ser Leu Ala Val Phe Lys Gly Gln Gly Thr Lys Glu T~ir Glu Ile His His Gly Lys Lys I.Le Leu Tyr Asp Ile Leu Ala P:ne Ala Lys Glu Ser Val Asn Ser His Val Thr Thr Leu Gl.y Pro Gln Asn Phe Pro Ala Asn Asp Lys Glu Pro Trp Leu Val Asp Phe Phe Ala Pro Trp Cys Pro 42= 430 435 Pro Cys Arg Ala Len Leu Pro f:~lu Leu i?rg Arg Ala Ser Asn Leu Leu Tyr Gly Gln Leu Lys Fhe Gly Thr Leu Asp Cys Ttr Val His Glu Gly Leu Cys Asn Met iyr Asn I=Le Gln Ala Tyr Pro Thr Thr Val Val Phe Asn Gln Ser Asn Ile His Glu Tvrr Glu Gly His His Ser Ala Glu Gln Ile Leu Glu Phe Ile Glu Asp Leu Met Asn Pro 500 505. 510 Ser Val Val Ser Leu Thr Pro Thr Thr Phe Asn Glu Leu Val Thr Gln Arg Lys His Asn Glu Val Trp hlet Val Asp Phe Tyr Ser Pro Trp Cys His Pro Cys Gln Val Leu Met Pro (_~lu Trp Lys Arg Met Ala Arg Thr Leu Thr G1y Leu Ile Asn Val G1y Ser Ile Asp Cys Gln Gln Tyr His Ser Phe Cys Ala Gln Glu Asn Val Gln Arg Tyr 5~?5 580 585 Pra Glu Ile Arg Phe Phe Pro Pro Lys Ser Asn Lys Ala Tyr G1n Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp Ala Tyr Ser Leu Arg Ile Trp Gly Leu G1y Phe Leu Pro Gln Val Ser Thr Asp Leu Thr Pro Gln Thr Phe Ser Glu Lys VaLeu Gln C~ly Lys Asn His Trp Val Ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln Asn Phe Ala Pro Glu Phe Glu Leu lieu Ala Arg Met Ile Lys Gly Lys Val 665 670 6?5 Lys Al.a Giy Lys Val Asp c:ys Gln Ala Tyr A1a Gln Thr Cys G.ln 680 6f.5 690 Lys Ala Gl.y Ile Arg Ala Tyr Pro 'rhr V.al Lys Phe Tyr Phe Tyr Glu Arg Ala Lys Arg Asn Phe Gln Glu G.lu GIn Ile Asn Thr Arg 710 715 l20 Asp Ala Lys Ala Ile Ala Ala I.~eu Ile F>ex: Glu Lys Leu Glu Thr 'J2'. '?30 735 Leu Arg Asn Gln Gly Lys Arg isn Lys Asp Glu Leu '14(J 795 <2I0> 460 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> i-29 <223> Artificial Sequence <400> 460 actccccagg ctgttcacac tgcc 29 <210> 961 <211> 24 <212> DNA
<2i3> Artificial <220>
<221> Artificial Sequence <222> i-24 <'223> Artificial Sequence <400> 461 gatcagccag ccaataccag cagc 2~
<210> 962 <211> 50 <212> DNA
<213> Artificial <220>
<221.> Artificial Sequence <~222> 1-50 <:223> Artificial Sequence <900> 462 gtggtgatga tagaatgctt tgccgaatga aaggagtcaa cagctatccc 50 <210> 463 <211> 1818 <212> DNA
<213> Homo sapi.ens <40C> 463 agacagtacc tcctccctag gac:tacacaa ggactgaacc agaaggaaga 50 ggacagagca aagccatgaa catcatccvt.a gaaatccttc t.gcttctgat 100 caccatcatc tactcctac;t tggagtcgtt ggtgaagttt ttcattcctc 150 agaggagaaa atctgtggct ggggagattg tt:ctcattac tggagct.ggg 200 catggaatag gcaggcagac tacttatgaa tttgcaaaac gacagagcat 250 attggttctg tgggatatta at.aagcgcgg tgtggaggaa actgcagctg 300 agtgccgaaa actaggcgtc actgc:g<.:~atg cgtatgtggt agactgcagc 350 aacagagaag agatctatcg ctctct.iaat c:aggtgaaga aagaagtggg 400 tgatgtaac:a atcgtggtga ataatgctgg gacagtatat ccagccgatc 950 ttctcagcac caaggatgaa gagattacca agacatttga ggtcaacatc 500 ctaggacatt tttggatcac: <3aaagc-actt ctt:ccatcga tgatggagag 550 aaatcatggc cacatcgtca ~~agtgclcttc agt:.gtgcgg<: cacgaaggga 600 ttccttacct catcccatat tgttccagca aatttgccgc tgttggcttt 650 cacagaggtc tgacat;:aga acatcaggcc ttgggaaaaa ctggtatcaa 700 aacctcatgt ctctgcccag tttttgtgaa tactgggttc accaaaaatc 750 caagcacaag attatggcct gtattggaga cagatgaagt cgtaagaagt 800 ctgatagatg gaatacttac caataagaaa a~gatttttg ttccatcgta 850 tatcaatatc tttctgagac tacagaagtt tcttcctgaa cgcgcctcag 900 cgattttaaa tcgtatgcag aatattcaat ttgaagcagt ggttggccac 950 aaaatcaaaa tgaaatgaat aaataagctc cagccagaga tgtatgcat.g 1000 ataatgatat gaatagtttc gaatcaatgc tgc~aaag<at tatttcacat 1050 tttttcagtc ctgataatat taaaaacatt ggtttggcac tagcagcagt 1100 caaacgaaca agattaatta cctgtcttcc tgtt:t:ctcaa gaatatttac 1150 gtagtttttc ataggtctgt tttt<.ctttc atgcctctt:a aaaacttctg 1200 tgcttacata aacatactta aaaggttttc tttaagatat tt:tatttttc 1250 catttaaagg tggacaaaag ctacctccct aaaagtaaat acaaagagaa 1300 cttatttaca cagggaaggt ttaagactgt tcaagtagca ttccaatctg 1350 tagccatgcc acagaatatc aacaagaaca cagaatgagt gcacagc:taa 1400 gagatcaagt ttcagcaggc agc;rttatct caa~~ctggac atatttta<ig 1450 attcagcatt tgaaagattt. ccctagcctc ttcctt:tttc:attagcccaa 1500 aacggtgcaa ctctattctca gactttatta cttgar.tctg tcttctgtat 1550 aactctgaag tccaccaaaa gtggaccctc tatatttcct ccctttttat 1600 agtcttataa gatacattat gaaaggtgac cgactctat:t ttaaatct_ca 1650 gaattttaag ttctagcccc atgataacct ttttcat.tgt aatttatgct 1700 ttcatatatc: cttggtccca gagatgttta gacaatttta ggctcaaaaa 1750 ttaaagctaa cacaggaaaa ggaactgtac tcgctattac ataagaaaca 1800 atggacccaa gagaagaa 181E
<210> 469 <211> 300 <212> PRT
<213> Homo Sapiens <400> 469 Met Asn Ile Ile Leu Glu Iie L.eu Leu Leu Leu Iie Tt~r Ile Ile Tyr Ser Tyr Leu Glu Ser Leu val Lys Phe Phe Ile Fro Gln Arg Arg Lys Ser Val Ala Gly Glu I1e Val Leu Ile Thr Gly Ala Gly His Gly Tle Gly Arg Gln Thr Thr Tyr Glu Phe Ala Lys Arg Gln Ser Ile Leu Val Leu Trp Asp Ile Asr_ Lys Arg Gly Val Glu Glu Thr Ala Ala Glu C:ys Arg Lys Leu Gly Val Thr Ala His Ala Tyr Val Val Asp Cys Ser Asn Arg Glu Glu Ile Tyr Arg Ser Leu Asn Gln Val Lys Lys Glu Val G.ly Asp Val Thr lle Val Val Asn Asn Ala Gly Thr Val Tyr Pro Ala Asp Leu Leu Ser Thr Lys Asp Glu Glu Ile Thr Lys Thr Phe Gl.u Val Asn Ile Leu Gly His Phe Trp lle Thr Lys Ala Leu Leu Pro Ser Met Met Glu Arg Asn His Gly His Tle Val Thr Val Ala Se:r Val Cys Gly His Glu Gly !:1e Pro Tyr Leu Ile Pro Tyr Cys Ser Ser Lys Phe Ala Ala Val Gly Phe i85 190 195 Hi.s Arg G1y Leu Thr Ser G.Lu Leu Gln Ala Leu Gly Lys Thr Gly ale Lys Thr Ser Cys Leu Cys Prc~ Val Phe Val Asn Thr Gly Phe Thr Lys Asn Pro Ser Thr Arg Leu Trp Pro Val Leu Glu Thr Asp Glu Val Val Arg Ser Leu I.le AsP~ Gly Ile Leu 'Thr Asn Lys Lys 295 25(7 255 Met Ile Phe 'Jal Pro Ser Tyr I1<> Asn Ile Phe Leu Arg Leu Gln 260 26.'i 270 Lys Phe Leu Pro Glu Arg Al.a SeAla Ile Leu Asn Arg Met Gln 275 28» 285 Asn Ile Gln Phe Glu Ala Val Val Gly His Lys Iie Lys Met Lys 290 29, 300 <210> 465 <211> 154'7 <212> bNA
<213> Homo Sapiens <400> 965 cggcggcggc tgcgggcgcg aggtgagggg cgc:gaggtga gg ggcgcgag 50 gttcccagca ggatgccccg gctctgcagg aagctgaagt gagaggcccg 100 gagagggccc agcccgcccg gggcaggat.g accaaggcc:c ggctgttccg 150 gctgtggctg gtgctggggt cggtgttcat gat:cctgct_g atcatcgtgt 200 actgggacag cgc:aggcgcc gcgcacttc:t acttgcacac gtccttct:ct 250 aggccgcaca cggggccgcc gctgc;ccacg cccgggccgg acagggac;ag 300 ggagctcacg gccgactccg atgtcgacga gtttctggac aagttt.ctca 350 gtgctggcgt gaagcagagc gaccttccca gaaaggagac ggagcagccg 900 30i cctgcgccgg ggagcatgga ggagagcgt~x agaggctacg actggtcccc 950 gcgcgacgcc cggcgcagcc cagacc:aggg ccggcagcag gcggagcgga 500 ggagcgtgct gcggggcttc t:gcc;cc:aact ccagcctggc cttccccacc 550 aaggagcgcg cattcgacga catccccaac tcggagctga gccacctgat 600 cgtggacgac cggcacgggg ccatct=actg ctacgtgccc aaggtggcct 650 gcaccaactg gaagcgcgtg atgatcgtgc tgagcggaag cctgctgcac 700 cgcggtgcgc cctaccgcga cccgctgcgc atcccccgcg agcacgtgca 750 caacgccagc gcgcacctga cctt~caacaa gttctc(gcgc cgctacggga 800 agctctcccg ccacctcatg aaggt~~aacac tcaagaagta caccaagtwe 850 ctcttcgtgc gcgacccctt cgtgcgcci:g atctcc:gcct r_ccgcagcaa 900 gttcgagctg gagaacgagg agttctacc:~g caagticgcc gtgcccatgc 950 tgcggctgta cgccaaccac accagcctctc ccgcctcggc gc:gcgaggcc 1000 ttccgcgctg gcctcaaggt gtccttcgc:c aacttcatcc agtacctgct 1050 ggacccgcac acggagaagc tggcgccctt c:aacgagcac tggcggcagg 1100 tgtaccgcct ctgccacccg tgccagatcg act.acgactt cgtggggaag 1150 ctggagactc tggacgagga cgccgcgcag ctgctgcagc tactccaggt 1200 ggaccggcag ctccgcttcc ccccgagcta ccggaacagg accgccagca 1250 gctgggagga ggactggttc gccaagatc:c ccctggcctg gaggcagcag 1300 ctgtataaac tctacgaggc cgactttgtt ctcttcggct accccaaqcc 1350 cgaaaacctc ctccgagact. gaaagctttc gc:gttgcttt ttctcgcgtg 1900 cctggaacct gacgcacgcg cactccagtt tt.tttatgac ctacgatttt 1450 gcaatctggg cttcttgttc actccactgc ctctatccat tgagtacr_gt 1500 atcgatattg ttttttaaga ttaatatatt tcagcttattt aatacga 1597 <21.0> 466 <211> 414 <27.2> PRT
<213> Homo sapiens <400> 966 Met Thr Lys Ala Arg Leu Phe Arg Leu Trp Leu Val Leu Gly Ser Val Phe Met Ile Leu Leu Ile I1e Val Tyr Trp Asp Ser Al.a Gly 20 ~5 30 Ala Ala His Phe Tyr Leu His T~~r Ser Phe Ser Arg Pro His Thr Gly Pro Pro Leu Pro Thr Pro Gly Pro Asp Arg Asp Arg Glu Leu Thr Ala Asp Ser Asp Val Asp Glu Phe Leu Asp Lys Phe Leu Ser Ala Gly Val Lys GLn Ser Asp Leu Pro Arg Lys Glu Thr Glu Gln Pro Pro A1a Pro Gly Ser Met Glu Glu Ser Val. Arg Gly Tyr Asp Trp Ser Prc Arg Asp Ala Arg Ara Ser Prc Asp C~ln Gly Arg Gln Gln Ala Glu Arg Arg Ser Val Leu Arg Gly Phe C'ys Ala Asn Ser i25 130 135 Ser Leu Ala Phe Pro Thr L.,~s G1~: Arg Ala Phe Asp Asp Lle Pro Asn Ser Glu Leu Ser Hi.s Leu Ile Val Asp Asp Arg His GLy Ala Ile Tyr Cys Tyr Vai Pro Lys Va.Ala Cys Thr Asn Trp Lys Arg 170 17!. 180 Val Met Ile Val Leu Ser Gly Ser Leu Leu His Arg Gly Ala Pro Tyr Arg Asp Pro Leu Arg Ile Pr;~ Arg Glu His Val His Asn Ala Ser Ala His Leu Thr Phe Asn Lys Phe Trp Arg Arg Tyr Gly Lys Leu Ser Arg His Leu Met Lys Val Lys Leu Lys Lys Tyr Thr Lys Phe Leu Phe Val Arg Asp 1'ro Fhe Val Arg Leu Ile Ser Ala Phe Arg Ser Lys Phe G1u Leu Glu Asn Glu Glu Phe Tyr Arg Lys Phe Ala Val Pro Met Leu Arg Leu Tyr Al.a Assn His Thr Ser Leu Pro Ala Ser Ala Arg Glu Ala Phe Arg Ala Gly Leu Lys Val Ser Phe Ala Asn Phe Ile Gln Tyr Leu Leu Asp Pro His Thr Glu Lys Leu 305 3:10 315 Ala Pro Phe Asn Glu His Trp Aog G.ln Val Tyr Arg Leu Cys His Pre Cys Gln Ile Asp Tyr Asp Pt:e Val Gly Lys Leu Glu Thr Leu Asp Glu Asp Ala A1a Gln Leu Leu Gln Leu Leu Gln Val Asp Arg Gln Leu Arg Phe Pro Pro Ser Tyr Arg Asn Arg Thr Ala Ser Ser Trp Glu Glu Asp Trp Phe A~.a Lys Ile Pro Leu Ala Trp Arg Gln

3 8 '~

Gln Leu Tyr Lys Leu Tyr G:i.u Ala Asp Phe Val Leu Phe Gly Tyr 395. 90C? 905 Pro Lys Pro Glu Asn Leu Leu Arg Asp <210=> 967 <211> 1071 <212:> DNA
<213> Ilomo sapiens <400> 467 tcgggccaga attcggcacg aggc:ggcacg agggcgacgg cctcacgggg 50 ctttggaggt gaaagaggcc cagaatagag agagagagag accgacgtac I00 acgggatggc tacgggaacg cgcaatgccg ggaaggtggt ggtcgtgacc 150 gggggcgggc gcggcatcgg agctgggatc gtgcgcgcct tcgtgaac:ag 200 cggggcccga gtggttatct gcgac:aagga tgagtctggg ggccgggccc 250 tggagcagga gctccctgga gctgtcttta tcctctgtga tgtgactcag 300 gaagatgatg tgaagaccct ggt:ttctgag accatccgcc gatttggccg 350 cctggattgt gttgtcaaca acgc~gge:ca ccacc:caccc ccacagaggc 900 ctgaggagac ctctgcccag ggattccacc agctgctgga gctgaaccta 450 ctggggacgt acaccttgac caagctcc~cc ca cccctacc tgcggaagag 500 tcaagggaat gtcatcaaca tctccagc:ct ggtgggggca atcggcc.agg 550 cccaggcagt tccctatgtg gccaccaagg gggcagtaac agccsatgacc 600 aaagctttgg ccctggatga aagtccat:at ggtgtccgag t=caactgtat 650 ctccccagga aacatctgga ccccgct~-~tg ggaggagctg gcagccttaa 700 tgccagaccr_ tagggccaca atccgaga gg gcatgctggc ccagccactg 75U
ggccgcatgg gccagcccgc tgaggtcggg gctgcggcag tgttcctggc 800 ctccgaagcc aacttctgca cc~ggcatt.ga actgctcgtg acggggggtg 850 cagagctggg gtacgggtgc aaggccagtc ggagcacccc cgtggacgcc 900 cccgatatcc cttcctgatt t!-tctcattt c:tactt.gggg cccccttcct 950 aggactctcc caccccaaac tccaacctgt atcagatgca gcccccaagc 1000 ccttagactc taagcccagt tagcaaggtg ccgggt.cacc ctgcaggttc 1050 ccotaaaaac gatttgcagc c 1071 <2I0> 468 <211> 270 <212> PRT

<213> Homo Sapiens <400> 468 Met Ala Thr Gly Thr Arg Tyr Ala Gly :Lys Va1 Val Val Val Thr 1 ' 10 15 Gly Gly Gly Arg Gly Ile G:l.y Ala Gl.y Ile Val Arg Ala Pte Val 20 2_'> 30 Asn Ser Gly Ala Arg Val Val Ile Cys Asp Lys Asp Glu Ser Gly 35 4(i 45 Gly Arg Ala Leu Glu Gln G.Lu Leu Pro G1~,~ Ala Val Phe Ile Leu 0 5'~ 6 0 Cys Asp Vai Thr Gln Glu Asp AsF% Val Lys Thr Leu Va1 Ser Glu Thr Ile Arg Arg Phe Gly Arg Lea Asp Cys Val Val Asn Asn Ala Gly His His Pro Pro Pro Gln Arg Pro Glu Glu Thr 5er Ala Gln Gly Phe Arg Gln Leu Leu Glu Leu Asrn Leu Leu Gly Thr Tyr Thr Leu Thr Lys Leu Ala heu Pro Tyr Let-: Arg Lys Ser Gl.n Gly Asn Val Ile Asn Ile Ser Ser Leu Va.1 Gly Ala Ile Gly Gln Ala Gln Ala Val Pro Tyr Val Ala '1'h_= Lys Gly Ala Val Thr Ala Met Thr Lys Ala Leu Ala Leu Asp Glu Ser Pro Tyr Gly Val Arg Val Asn 1;0 1'.?5 180 Cys Ile Ser Pro G1y Asn Ile Trp Thr Pro Leu Trp G1u G1u Leu 185 1!~0 195 Ala Ala Leu Met Pro Asp Fro Arg A1a Thr Ile Arg Glu Gly Met Teu Ala Gln Pro Leu Gly Arg Met Gly GLn Prc Ala Glu Val Gly Ala Ala Ala Val Phe Leu Ala Ser Glu Al.a Asn Phe Cys Thr Gly 230 2:35 290 Ile Glu Leu Leu Val Thr Gly GLy Ala Glu Leu Gly Tyr Gly Cys Lys Ala Ser Arg Ser Thr Pro Val Asp Ala Pro Asp Ile Pro Ser <21U> 969 <211> 687 <212> DNA
<213> Homo sapiens <400> 469 3 ?.1 aggcgggcag cagctgcagg ctgaccttac: agctt:Igcgg aatggactgg 50 cctcacaacc tgctgtttct tcttaccai.t: tc:<:atcttcc tggggctggg 100 ccagcccagg agccccaaaa gcaagaggaa ggggcaaggg cggcctgggc 150 ccctggcccc tggccctcac caggtgccac tggac~~tggt gtcac:ggatg 200 aaaccgtatg cccgcatgga ggagtatgag aggaacatcg aggagatggt 250 ggcccagctg aggaacagct cagagctggc ccagagaaag tgtgaggtca 300 acttgcagct gtggatgtcc aacaagagga gc<;tgtctcc ctggggctac 350 agcatcaacc acgaccccag ccgtatcccc gtggacctgc cggaggcacg 400 gtgcctgtgt ctgggctgtg tgaacccctt <:accatgcag gaggaccgca 950 gcatggtgag cgtgccggtg ttc:agccagg ttcctgtgcg ccgccgccac 500 tgcccgccac cgccc:cgcac agggcctt.gc cgccagcgcg cagtcatgga 550 gaccatcgct gtgggctgca cctgc atc:tt. ctgaatcacc t.ggcccagaa 600 gccaggccag cagcccgaga ccatcctoct tgcac:ctttg tgcc:aagaaa 650 ggcctatgaa aagtaaacac tg,~cttttga aagcaag 68~J
<210> 970 <21i> 180 <212> PRT
<213> Homo sapiens <900> 470 Met Asp Trp Pro His Asn Leu Leu Ptie Lc~u Leu Thr Ile Ser Ile Phe Leu Gly Leu Gly Gln Pro Arg Seer Pro Lys Ser Lys Arg Lys Gly Gln Gly Arg Pro Gly Pro Leu ALa Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Ile Glu Glu Met Val. Ala Gln Leu Arg Asn Ser Ser Glu heu Ala Gin Arg i,ys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg Ser Leu Ser Fro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu C:ly Cys Val Jsn Pro Phe Thr Met: Gln Glu Asp 125 7.30 135 Arg Ser Met Val Ser Val Pro Val Fhe Ser Gln Val Pro Val Arg 140 :L45 150 Arg Arg Leu Cys Pro Fro Pro Prc~ Ara, Thr Gly Fro C:ys Arg Gln 15s l6C:c 165 Arg Ala Val Met Giu Thr Tle A1<Val Gly Cys 'rhr Cys Ile Phe <210> 971 <211> 2368 <212=> DNA
<213> Homo Sapiens <400> 971 gcgccgccag gcgtaggcgg ggtggccctt gcgtctcccg cttccttgaa 50 aaacccggcg ggcgagcgag gctgcgggcc ggccgctgcc cttccccaca 100 ctccccgccg agaagcctcg ctcggcgccc aacatggcgg gtgggcgctg 150 cggcccgcag ctaacggcgc tcc::a ggccgc ctggatcgcg gctgtggc:gg 200 cgacggcagg ccccgaggag gccgc:gctgc cgc:cggagca gagccgggtc 250 cagcccatga ccgcctccaa ctqgacgctg gtgatggagg gcgagtggat 300 gctgaaattt tacgccccat ggtgt:ccatc ctgccagcag actgattcag 350 aatgggaggc ttttgcaaag aatggtgaaa tactt.cagat cagtgtgggg 900 aaggtagatg tcattcaaga accaggtttg agtggccgca tctttgtcac 450 cactctccca gcattttttc atc~caaactga tgggatattc cgccgttatc 500 gtggcccagg aatcttcgaa gacctgcaga attateatctt agagaagaaa 550 tggcaatc:aa tcgagcca ct gactggctgg aaat<:cccag cttctctaac 600 gatgtctgga atggctggtc tttttagcat ctct<lgcaag atatggcat~c 650 ttcacaacta tt.tcacagtg actcttggaa ttcc~:_gcttg gtgttcttat 700 gtgtttttcg tcatagccac ctt:ggttrt:t ggccttttta t=gggtctggt 750 cttggtggta atatcagaat gtttctargt gcca~~:ttcca aggcatttat 800 ctgagcgttc tgagcagaat cggagatcJag aggaggctca 1=agagctgaa 850 cagttgcagg atgcggagga ggaaaaagat gattcaaatg aagaagaaaa 900 caaagacagc cttgtagatg atgaagaaga gaaagaagat cttggcgatg 950 aggatgaagc agaggaagaa gagqaggagg ac:aacttggc tgctggt.gtg 1000 gatgaggaga gaagtgaggc caatgatcag gggcccccag gagaggacgg 1050 tgtgacccgg gaggaagtag agcctgagga ggctgaagaa ggcatct..ctg 1100 agcaaccctg cccagctgac acagaggtgg t:ggaagactc cttgaggcag 1150 cgtaaaagtc agcatgctga caagggactg tagatttaat gatgcgtttt 1200 caagaataca caccaaaaca atatgtcagc ttcc:ctttgg cctgcagttt 1250 3:3 gtaccaaatc r:ttaattttt cctgaatgag caagcttctc ttaaaagatg 1300 ctctctagtc atttggtctc atggcagtaa gcc:tcatgta tactaaggag 1350 agtcttccag gtgtgacaat caggat:atag aaaaacaaac gtagtgttgg 1400 gatctgtttg gagactggga tggctaacaag ttc:atttact taggggtcaig 1950 agagtctcga ccagaggagg ccat.tcccag tcctaatcag c:accttccag 1500 agacaaggct gcaggccctg tgaaatgaaa gccaagcagg agccttggct 1550 cctgagcatc cccaaagtgt aacgtagaag ccttgc:atcc t:tttcttgtg 1600 taaagtattt atttttgtca aattgcagra aacatcaggc accac:agtgc 1650 atgaaaaatc tttcacagct agaaattgaa agggccttgg gtatagagag 1700 cagctcagaa gtcatcccag ccct.ctga~:~t ctcctgtgct atgtrttatt 1750 tcttaccttt aatttttc:ca gcatttcca~c catgggcatt cagget.ctcc 1800 acactcttca ctattatctc ttggtcagag gactccaata acagccaggt 1850 ttacatgaac tgtgtttgtt catt:ctgar:c taaggggttt agataatcag 1900 taaccataac ccctgaagct gtgactgcc:a aac:atctcaa atgaaatgtt 1950 gtggccatca gagactcaaa aggaagtaag gattttacaa gacagattaa 2000 aaaaaaattg ttttgtccaa aatatagttg ttgttgattt ttttttaagt 2050 tttctaagca atatttttca agc:cagaagt cctctaagtc ttgccagt_ac 2100 aaggtagtct tgt.gaagaaa agt.tgaatac tgttttattt tcatctcaag 2150 gggttccctg ggtcttgaac tactttaata ataaotaaaa aaccacttct 2200 gattttcctt cagtgatgtg ct.vttggtga aagaattaat gaactccagt 2250 acctgaaagt gaaagatttg attttgtttc catct:tctgt aatcttccaa 2300 agaattatat ctttgtaaat ct:a caatac tcaatctact gtaagtaccc 2350 agggaggcta atttcttt 2368 <210> 472 <211> 34g <212> PRT
<213> Homo sapiens <900> 472 Met Ala Gly Gly Arg Cys Gly Pro Gln Leu Thr Ala Leu Leu Ala Ala Trp Ile Ala Ala Val Ala Ala Thr Ala Gly Pro Glu Glu Ala 20 '25 30 Ala Leu Pro Pro Glu Gln Ser Arg Va.L Gln Pro Met Thr Ala Ser Asn Trp Thr Leu Val Met Glu Gay c;l.u T'rp Met. Leu Lys Phe Tyr 37.4 Ala Pro Trp ~~ys Pro Ser Cys Gln Gln Thr Asp :.,er Glu Trp Glu 65 ~0 75 Ala Phe Ala Lys Asn Gly G.W Ile Leu Gln I1e Ser Val C~ly Lys Val Asp Val Ile Gln Gl.u Pro Gly Leu Ser Gly Arg Phe Phe Val Thr Thr Leu Fro Ala Phe Phe Hi:v Ala Lys Asp Gl.y Ile Phe Arg Arg Tyr Arc_ Gly Pro Gly I.Le Phe Glu Asp Leu Gln Asn T yr Ile Leu Glu L~ys Lys Trp Gln Ser Va-~ Glu Pro Leu 'Ihr Gly Trp Lys 5er Pro Ala Ser heu Thr Met Ser G.ly Met Ala Gly Leu Phe Ser Ile Ser Gly Lys Ile Trp His Le,. His Assn Tyr Fhe Thr Val Thr Leu Gly Ile Pro Ala Trp C:ys Ser Tyr Val Fhe Phe Val Ile Ala Thr Leu Va1 Phe Gly Leu Phe Met G1y Leu Val Leu Val Val Ile 2_00 205 210 Ser Glu Cys Phe Tyr Val Pro Leu Fro Arg His Leu Ser Glu Arg Ser Glu Gln Asn Arg Arg Ser Glu Glu Ala His Arg Ala Glu Gln 230 2.~5 240 Leu Gln Asp Ala Glu Glu Glu Lys Asp Asp Ser Asn Glu Glu Glu Asn Lys Asp Ser Leu Val Asp Asp Glu Glu Glu Lys Glu Asp Leu Gly Asp Glu Asp Glu Ala Glu G.iu Glu G:L.u Glu Glu Asp Asn Leu 2?5 280 285 Ala Ala Gly Val Asp Glu Glu Arg Ser Glu Ala Asn Asp Gln Gly Pro Pro Gly Glu Asp Gly Val Thr Arg Glu Glu Val Glu Pro Glu Glu Ala Glu Glu G1y Ile Ser GLu Gln Pro Cys Fro Ala Asp Thr Glu Val Val Glu Asp Ser Leu Arg Gln Arg Lys Ser Gln His Ala Asp Lys Gly Leu <210> 973 <211> 29 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence v 222> 1-2.4 ~'223> Artificial Sequence <400> 973 gtccagccca tgaccgcctc caac 29 <210> 974 <211> 24 <212> DNA
<213> Artificial t2LO>
<221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <900> 474 ctctcatcat ccacaccagc agcy 24 <210> 975 <211> 44 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-94 <223> Artificial Sequence <400> 975 gtggatgctg aaattttacg cc<:catggtg tccatc.ctgc cagc 94 <210> 476 <211> 2478 <212> DNA
<:213> Homo sapiens <400> 476 atctggttga actacttaag cttaattt:gt taaa<:tccgg taagtaccta 50 gcccacatga tttgactcag agattctcett ttgt<ecacag acagtcatct 100 caggggcaga aagaaaagag ctcccaaatg ctat<3tctat t.caggggctc 150 tcaagaacaa tggaatatca tc<agattta gaaaa tttgg atgaagatgg 200 atatactcaa ttacacttcg actctcaaag coat,~ccagg aatagctgttg 250 tttcagagaa aggatcgtgt gctgcat;:tc ctccttggcg cctcatt.gct 300 gtaattttgg gaatcctatg cttggtaata ctggtgatag ctgtggtcct 350 gggtaccatg ggggttcttt cc<3gcccttg tcctcctaat tggattatat 900 atgagaagag ctgt.tatcta ttcagcatgt cactaaattc ctgggatgga 450 agtaaaagac aatgctggca actgggctct aatctcctaa agatagacag 500 3i6 ctcaaatgaa ttgggattta tagtaaaaca agtgtcttcc caacctgata 550 attcattttg gataggcctt tctcggcccc agactgaggt accatggctc 600 tgggaggatg gatcaacatt ctcttctaac ttatttcaga t:cagaaccac 650 agctacccaa gaaaacccat ctccaaattg tgtaatggatt cacgtgtc<3g 700 tcatttatga ccaaci:gtgt agtgtgccct catatagt:at: tt.gtgagaag 750 aagttttcaa tgtaagagga agggtggaqa aggagagaga aatatgtgag 800 gtagtaagga ggacagaaaa cagaacagr~a aagagtaaca gctgaggtca 850 agataaatgc agaaaatgtt tagagagctt ggccaactgt aatcttaacc 90C
aagaaattga agggagaggc tgtgatttc_-t gt.atttgtcg ac:ctacaggt 950 aggctagtat tatttttcta gttagtagat c:ccaagacat ggaatcaggg 1000 cagccaagct tgagttttta ttttttattt att:tattttt ttgagatagg 1050 gtctcacttt gttacccagg ctggagtgc.a gtggcacaat ctcgactcac 1100 tgcagctatc tctcgcctca gccccacaag ta<~ctgggac tacaggtgca 1150 tgccaccatg ccaggctaat ttttggtgtt ttttgtagag actgggtt.tt 1200 gccatgttga ccaagctggt ctctaactc c tgggcttaag tgatctgccc 1250 gccttggcct cccaaagtgc tgggattaca gatgtgagcc accacacctg 1300 gccccaagct tgaattttca ttcagccatt gacttggcat ttaccttggg 1350 taagccataa gcgaatctta atttctgc;ct c:t:atc:agagt tgtttcatgc 1400 tcaacaatgc cattgaagtg cacggtgtgt tgccacgatt tgaccctcaa 1450 cttctagcag t:atatcagt.t atgaactgag ggtgaaatat: atttctgaat 1500 agctaaatga agaaatggga aaaaatcttc acca<.~agtca gagcaatttt 1550 attattttca tcagtatgat cataattatg attarcatct t:agtaaaaag 1600 caggaactcc tactttttct tt.atcaatta aatagctcag agagtacatc 1650 tgccatatct ctaatagaat cttttttttt tttttttttt tttgagacag 1700 agtttcgctc ttgttgccca ggctggagtg c:aacggc:acg atctcggctc 1750 accgcaacct ccgccccctg ggtt.caagca attctcctgc ctcagcctcc 1800 caagtagctg ggattacagt caggcaccac c<scacccggc: taattttgta 1$50 tttttttagt agagacaggg tttctccatg tcggtcaggg tagtcccgaa 1900 ctcctgacct caagtgatct gc:ctgcctcg gcctcccaag tgctgggatt 1950 acaggcgtga gccactgcac cc:agcctaga atcttgtata atatgtaatt 2000 gtagggaaac tgctctcata gga<iagtttt c:tgcatttta aatacaaaaa 2050 tacataaaaa tacataaaat ct=gatgatga atat:aaaaaa gtaaccaacc 2100 3 ~~. 7 tcattggaac aagtat.taac attttggaat atgttttatt agttttgtga 2150 tgtactgttt tacaat,tttt accaatttttt tcagtaatta cagtaaaatg 2200 gtattattgg aatgaaacta tati_tcctoa tgtgct.gatt tgtcttattt 2250 ttttcatact ttcccactgg tgctattttt atttc<:aatg gatatttctg 2300 tattactagg gaggcatt.ta cagtcctcra atgttgatta atatgtgaaa 2350 agaaattgta ccaattttac taaattatcc agtttaaaat ggatgatttt 2400 atgttatgtg gatttcattt caataaaaaa aaactcttat caaaaaaaaa 2450 aaaaaaaaaa aaaaaaaaaa aaaaaaaa 2478 <210> 477 <211> 201 <212> PRT
<213> Homo Sapiens <400> 477 Met Gl.u Tyr His Pro Asp Leu G1u Asn Leu Asp Glu Asp Gly Tyr Thr Gln Leu His Phe Asp Ser Gln Ser Asn Thr Arg Ile Ala Val Val Ser Glu Lys Gly Ser c;yS Ala Ala Ser Pro Pro Trp Arg Leu Ile Ala Val Ile Leu Gly lle Leu Cys Leu Val Ile Leu Val Ile 5'0 55 60 Ala Val Val Leu Gly Thr Met G::y Val Leu Ser 5er Pro Cys Pro 65 ~'0 75 Pro Asn Trp Ile Ile Tyr i_lu Lys Ser Cvs Tyr Leu Phe Ser Met 80 f35 90 Ser Leu Asn Ser Trp Asp Gly Seer Lys A:_g Gln Cys Trp Gln Leu Gly Ser Asn Leu Leu Lys Ile Asp Ser Ser Asn Glu Leu Gly Phe Ile Val Lys Gln Val Ser Ser G1n Pro Asp Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln Thr Glu Val. Pro Trp Leu Trp Glu Asp Gly Ser Thr Phe Ser Ser ASn Leu Phe Gln Ile Arg Thr Thr Ala Thr Gln Glu Asn Pro Ser Pro Asn Cys Val Trp Ile His Val Ser Val Ile Tyr Asp Gln Leu Cys Ser Val Fro Ser Tyr Ser Ile Cys Glu Lys Lys Phe Ser Met 3 _8 <210> 478 <211> 27 <212> DNA
<213> Artificial <220>
<221> Artificial :iequence <2 22> 1-27 <223> Artificial Sequence <400> 478 gtccacagac agtcatctca ggagcag ;'.
<210> 479 <211> 20 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-20 <223> Artificial Sequence <900> 479 acaagtgtct tcccaacctg 20 <210> 480 <211> G4 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <:222> 1-24 <:223> Artificial Sequence <:400> 980 atcctcccaq agccatggt.a cctc 24 ~~210> 481 ~:211> 51 <?_ 12 > DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-51 <223> Artificial Sequence <900> 981 ccaaggatag ct:gttgtttc agagaaagga tcgtgtgctg catctcctcc 50 t 51 <210> 482 <211> 3819 <212> DNA
<213> Homo sapiens <900> 482 ggaaggggag gagcaggcca cacaggcaca ggcc:ggtgaq ggacctgccc 50 agacctggag ggtctcgctc tgtcacacag gctggagt.gc agtggtgtga 100 tcttggctca tcgtaacctc cacctc:ccgg gttcaagtga ttctcatgcc 150 tcagcctccc gagtagctgg gatt.acaggt ggtgacttcc aagagtgac:t 200 ccgtcggagg aaaatgactc cccagtcgct gctgcagacg acactgttc:c 250 tgctgagtct gctcttcctg gtcca<~ggtg cccaccigcag gggccacag g 300 gaagactttc gcttctgcag ccac3cggazzc cagacacaca ggagcagcct 350 ccactacaaa cccacaccag acctgcgca:t ctccat:cgag aactc:cgaag 400 aggccctcac agtccatgcc cctttccct:.g cagccoac;cc tgcttcccga 450 tccttccctg accccagggg cct.ct.accaac ttctgcctct actggaaccg 500 acatgctggg agottacatc: ttctctatgg caagcgtgac tt:cttgctga 550 gtgacaaagc ctctagcctc ctctgcttcc agcac~agga ggagagcctg 600 gctcagggc:c ccccgctgtt agccacttat gtc.acctcct ggtggagccc 650 tcagaacatc agcctgccca gtgccgccag ctt:caccttc tccttccaca 700 gtcctcccca cacggccgct cacaatgcct cggtggacat gtgcgagctc 750 aaaagggacc tccagctgct cagccagttc ctgaagcatc cccagaaggc 800 ctcaaggagg ccctcggctg ccc:ccgccag ccagcagttg cagagcctgg 850 agtcgaaact gacctctgtg agatt_catgg gggac:atggt gtccttcgag 900 gaggaccgga tcaacgccac ggtgtggaag ctccagccca cagccggcct 950 ccaggacctg cacatccact cccggcagga ggaggagcag agcgaga=ca 1000 tggagtactc ggtgctgctg cctcgaac;ac tcttc;cagag gacgaaaggc 1050 cggagcgggg aggctgagaa gag actcr;tc ctggt:ggact tcagcagcca 1100 agccctgttc caggacaaga attccagc:c;a agtcctgggt gagaaggtct 1150 tggggattgt; g gtacagaac accaaag;.ag ccaacctcac ggagcccgtg 1200 gtgctcac;tt tccagcacca gc.tacag%;cg aagaatgtga c:tctgcaatg 1250 tgtgttctgg gttgaagacc ccacattgag cagcc:cgggg cattggagca 1300 gtgctgggtg tgagaccgtc aggagagaaa ccca.aacatc ctgcttctgc 1350 aaccacttga cctactttgc agtgctgatg gtctcctcgg tggaggtgga 1400 cgccgtgcac aagcactacc tgagcctcct ctcctacgtg ggctgtctcg 1450 tctctgccct ggcctgcctt gt.caccattg ccgcctacct ctgctccagg 1500 gtgcccctgc cgtgcaggag gaaacctcgg gactacacca tcaaggtgca 1550 catgaacctg ctgctggccg tc.ttcctgct ggacacgagc ttcctgca ca 1600 gcgagccggt ggccctgaca ggctctgagg ctggctgccg agccagtgcc 1650 atcttcctgc acttctccct gctcacctgc ctti=cctgga tgggcctcqa 1700 ggggtacaac ctctaccgac tcgtggtgga ggt.ctttggc acctatgtcc 1750 ctggctacct actc:aagctg agcgc<:atag gctggggct.t ccccatcttt 1800 ctggtgacgc tggtggccct ggtggatgtg gacaactotg gccccatcat 1850 cttggctgtg cataggactc cagagggcgt catctaccct tccatgtgct 1900 ggatccggga ctccctggtc agcr_a~~atca ccaacctggg cctcttcagc: 1950 ctggtgtttc tgttcaacat ggc~~atgcta gccaccatgg tggtgcagat. 2000 cctgcggctg cgcccccaca cccaaaagrg gtcacatgtg ctgacactgc 2050 tgggcctcag cctggtcctt ggc~ctgccct gggccttgat cttcttctcc 2100 tttgct.tct=g gcaccttcca gcttgtcga~c ctcta~~cttt tcagcatcat 2150 cacctccttc caaggcttcc tcatcttcat ctggtactgg tccatgcggc 2200 tgcaggcccg gggtggcccc tcccctctga agagcaact.c agacagcgcc 2250 aggctcccca tcagctcggg cac~cacctcg tccagccgca tctaggcctc 2300 cagcccacct gcccatgtga tgaagcagag atgcggcctc gtcgcacact 2350 gcctgtggcc cccgagccag gcc:cagcccc aggccagtca gccgcagact 2900 ttggaaagcc caacgaccat ggagagatgg gccgttgcca tggtggac:gg 2450 actcccgggc tgggcttttg aattggccr_t ggggactact cggctctc;ac 2500 tcagctccca cgggactcag aagtc~cgccg ccatgctgcc tagggtac~tg 2550 tccccacatc tgtcccaacc cagctggagg cctggtc.tct ccttacaacc 2600 cctgggccca gccctcattg ctgggggc:ca ggcct:tggat c.ttgagggtc 2650 tggcacatcc t:taatcctgt gcccctgc:ct gggac:agaaa tgtggctcca 2700 gttgctctgt. ctctcgtggt ca~,cctga:~gg gcaci=ctgca tcctctgtca 2750 ttttaacca c aggtggcac:c cagggcgaat ggggc:ccagg gcagaccttc 2800 agggccagag ccctggcgga ggagaggc:cc tttg~~cagga gcacagcagc 2850 agctcgccta cctct.gagcc caggccccct ccctccctca gccccccagt 2900 cctccctcca tcttccctgg ggttctcctc ct:ctcccagg gcctccttgc 2950 tccttcgttc acagctgggg gtccccgatt ccaatgctgt tttttgggga 3000 gtggtttcca ggagctgcct ggtc~tctgct gtaaatgttt gtctactgca 3050 caagcctcgg cctgccc:ctg agccaggctc ggtaccgatg cgtgggctgg 3100 gctaggtccc tctgtccatc tgggcctttg tatgagctgc: attgcccatg 3150 ctcaccctga ccaagcacac gc..ctcagagg ggccctcagc: ctctcct~gaa 3200 gccctcttgt ggcaaqaact gtgqaccatg ccagtcccgt ctggtttcca 3250 tcccaccact ccaaggactg agactgacct cct:ctggtga cactggccta 3300 gagcctgaca ctctcctaag aggttctctc caagccccca aatagctcc:a 3350 ggcgccctcg gccgcccatc atg<lttaatt ctgtcc:aaca aacacacacg 3900 ggtagattgc tggcctgttg taggtggta:g ggacacagat gaccgacctg 3450 gtcactcctc ctgccaacat tcagtctgc~t atgtgaggcg tgcgtgaagc. 3500 aagaactcct ggagctacag ggacagggaYg ccatc<3tt.cc tgcctgggaa 3550 tcctggaaga cttcctgcag gagtcagccft: tcaatcttga ~:rttgaagat 3600 gggaaggatg ttctttttac gtaccaatt_c: t.tttg-cttt tgatattaaa 3650 aagaagtaca tgttcattgt. agagaatttg gaaactgtag aagagaatca 3700 agaagaaaaa taaaaatcag ctgttgtaat cgcctagcaa aaaaaaaaaa 3750 aaaaaaaaaa aaaaaaaaaa aaaaaaaa<-~a aaaaaaaaaa aaaaaaaaaa 3800 aaaaaaaaaa aaaaaaaaa 3819 <210> 983 <211> 693 <212> PRT
<213> Homo Sapiens <900> 983 Met Thr Pro Gln Ser Leu Leu G1n 'I'hr Tr.r Leu Phe Leu Leu Ser Leu Leu Phe Leu Val G In Gly Ala Hi.s Gl y Arg Gly His Arg Glu Asp Phe Arg Phe Cys Ser c~ln Arg Asn Gln Thr His Arg Ser Ser Leu His Tyr Lys Pro Thr Pro Aap Leu Arg Ile Ser Ile G:Lu Asn 50 .'~5 60 Ser Glu Glu Ala Leu Thr Val Hi.s Ala P:ro Phe Pro Ala Ala His 65 ?0 75 Pro Ala Ser Arg Ser Phe Pro Asp Pro Arg Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu heu Cys Phe Gln His Gln Glu G7_u Ser Leu Ala Gln Gly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser T'rp Trp Ser Pro Gln Asn I1e Ser Leu Pro Ser Ala Ala Ser Phe Thr Phe Ser Phe His Ser f'ro Pro His Thr Ala Ala His Asn A7.a Ser Val Asp Met Cys Glu heu Lys Arg Asp Leu Gln Leu Leu Ser Glr: Phe :Leu Lys His F'ro Gln Lys Ala Ser Arg Arg Prc Ser Ala Ala Pro Ala Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr Sez: Val Arg Phe Met Gly Asp Met Val Ser Phe Glu Glu Asp Arg I1<> Asn Ala Thr Val 'I'rp Lys Leu 230 23.'; 290 Gln Pro Thr Ala Gly L~eu Gl.n Asp Leu His Ile His Ser Arg Glr!

Glu G'_u Glu Gl.n Ser Glu Ile Met Glu Tyr Ser Val Leu Leu Pro 260 26'; 270 Arg Thr Leu Phe Gln Arg Thr Lys Gly Arg Ser Gly Glu Ala Glu Lys Arg Leu Leu Leu Va1 Asp Phe Ser Ser Gln Al.a Leu Fhe G1n Asp Lys Asn Ser Ser Gln Va-_ Leu Gly Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val 320 32'5 330 Leu Thr Phe Gln His Gln Leu Gln Pro Lys Asn Val Th r Leu Gln Cys Val Phe Trp Val Glu Asp Pr-o Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly Cys Glu Tt~~r Val Arg Arg Glu Thr Gln Thr 365 3'70 375 Ser Cys Phe Cys Asn His Leu Ttor Tyr Phe Ala Val Leu Met Ual 380 3.35 390 Ser Ser Vai Glu Val Asp Ala Val Hip; Lys His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser Ala Leu Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu Cys Ser Arg Val Pro Leu Pro Cys Arg Arg Lys Pro Arg Asp Tyr Thr Ile Lys Val. His Met Asn Leu Leu Leu Ala Val Phe Leu Leu Asp T'hr Ser Phe Leu Leu Ser Glu Pro 3a?3 Val Ala Leu Thr Gly Ser G1u Ala Gly C:ys Arg AIa Ser AIa Ile Fhe Leu His Phe Ser Leu Leu Thr Cys i~eu Ser Trp Met c;ly Leu Clu Gl.y Tyr Asn heu Tyr Arg Leu Val Val Glu Val Phe (~ly Thr 500 50'. 510 Tyr Va1 Pro Gly Tyr Leu Leu Lye. Leu Ser Ala Met Gly T rp Gly 51 ' 52() 525 Phe Fro Ile Phe Leu Val T'hr Leu Val Ala Leu Val Asp Vai Asp Asn Tyr Gly Pro Ile Ile Leu A1<: Val His Arg TYrr Pro Glu Gly Val Ile Tyr Pro Ser Met C'ys Trx:~ Ile Ar~a Asp Ser Leu Val Ser 560 56~ 570 Tyr Ile Thr Asn Leu Gly Leu Phe Ser Leu Val Phe Leu Phe Asn Met AIa Met Leu Ala Thr Met Val Val G:Ln Ile Leu Arg Leu Arg Pro His Thr Gln Lys Trp Ser Hi.s Va.l Leu Thr Leu Leu Gly Leu Ser Leu Va1 Leu Gly Leu l'ro 'T'rp Ala Leu I l a Phe Pt:e Ser Phe Ala Ser Gly Thr Phe Gln Leu Val Val Leu Tyr Leu Phe Ser Ile I1e Thr Ser Phe Gln Gly PhE= LEeu IIe Phe Ile Trp Tyr Trp Ser Met Arg Leu Gln Aia Arg t.~ly G;iy Pro Ser Pro Leu Lys Ser Asn 665 6'~0 675 Ser Asp Ser Ala Arg Leu Pro Ile Ser Seer Gly Ser Thr Ser Ser Ser Arg Ile <210> 484 <211> 516 <212> DNA
<213> Homo sapiens <220>
<221> unsure <222> 68, 70, 89, 197 <223> unknown base <900> 484 tgcctggcct gccttgtcaa caatgccgct tactctgctt ccaggttgcc 50 ctgccttgca gaggaaancn tcgggactac accn.tcaagt; gcacatgaac 100 ctgctgctgg ccgtcttcct gctggacacg agcttcctgc tcagcgnagc 150 cggtggccct gacaggctct gaaggctggc tgccgagcca gtgccatctt 200 cctgcacttc tcctgctcac ctgc.ctttcc tggatgggcc tcgaggggt.a 25G
caacctctac cgactcgtgg tggaggtctt tggcacctat qtccctggct 300 acctactcaa gctgagcgcc atgggctggg gcttccccat ctttctggtg 350 acgctggtgg ccctggtgga tgtggaca~~c tatggc:ccca tcatcttggc 400 tgtgcatagg actccagagg gcgtc,atcta cccttc:catg tgctggatcc 450 gggactccct ggtcagctac atcaccaaoc tgggcctctt cagcctggtg 500 tttctgttca acatgg 516 <210> 985 <211> 22 <2i2> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-22 <223> Artificial Sequence <900> 985 ggcattggag cagtgctggg tg 22 <210> 486 <211> 24 <212> DNA
<:213> Artificial <220>
<:221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <900> 486 tggaggccta gatgcggctg gacg 29 <210> 48%
<21.1> 2849 <212> DNA
<21.3> Homo sapiens <220>
<221> unsure <222> 2715 <223> unknown base <400> 48?
cggacgcgtg ggcggacgcg tgggcgga cg cgtgggcgga cgcgtgggct 50 ggttcaggtc caggttttgc tttgatcctt ttcaaaaact ggagacacag 100 aagagggctc taggaaaaag tttt=ggatgg gattatgtgg aaactaccct 150 gcgattctct gctgccagag caggctcggc gcttccaccc cagtgcagcc 200 ttcccctggc ggtggtgaaa gagactcggg agtcgc'vgct tccaaagtgc 250 ccgccgtgag tgagctctca ccccagtcag ccaaatgagc: ctcttcgggc 300 ttctcctgct gacatctgcc ctggccggcc agagacaggg gactcaggcg 350 gaatccaacc tgagtagtaa attc.cagttt tccagcaaca aggaacagaa 400 cggagtacaa gatcctcagc atgagagaat tattacagtg t:ctactaat:g 450 gaagtattca cagcccaagg tttcctcata cttatc:caag aaatacggtc 500 ttggtatgga gattagtagc agtagaggaa aatgtatgga tacaacttac 550 gtttgatgaa agatttgggc ttgaagacr:c agaagatgac ;~tatgcaagt: 600 atgattttgt agaagttgag gaacccagtg atggaa ctat attagggcgc 650 tggtgtggtt ctggtactgt acc:aggaa,~a cagat.ttcta aaggaaatca 700 aattaggata agatttgtat ctgatgaata ttttc~~ttct gaaccagggt 750 tctgcatcca ctacaacatt gtc:atgcc;~c aat:tcacaga agctgtgagt 800 ccttcagtgc tacccccttc agctttgc~:a ctggacctgc ttaataatgc 850 tataactgcc tttagtacct tggaagacct tattcgatat cttgaacc:ag 900 agagatggca gttggactta gaagatctat ataggccaac ttggcaac:tt 950 cttggcaagg cttttgtttt tggaagaaaa tcc~agagtgg tggatctgaa 1000 ccttctaaca gaggaggtaa gattatacag ctgcacacct cgtaactt:ct 1050 cagtgtccat aagggaagaa ctaaagaqaa ccgat.accat tttctggr:ca 1100 ggttgtctcc t:ggttaaacg <ac~tclgtc~gg aactcJtgcct gttgtctcca 1150 caattgcaat gaatgtcaat gtgt~~ccaaag c;aaac~ttact aaaaaatacc 1200 acgaggtcct tcagttgaga ccaaagao cg gtgtcagggg attgcacaaa 1250 tcactcac:cg acgtggccct ggagcac<;at gagg<igtgtg actgtgtgtg 1300 cagagggagc acaggaggat agccgcat:ca ccacc,agcag c:tcttgccca 1350 gagctgtgca gtgcagtggc tgattctatt agagaacgta t:gcgttatct 1900 ccatccttaa tctcagttgt ttgcttcaag gacctttcat cttcaggatt 1450 tacagtgcar_ tctgaaagag gagacataaa acagaattag gagttgtgca 1500 acagctcttt tgagaggagg cctaaaggac aggagaaaag gtcttcaatc 1550 gtggaaagaa aattaaatgt tgtattaaat agatcaccag ctagtttcag 1600 agttaccatg tacgtattcc actagctggg ttctgtattt cagttctttc 1650 gatacggctt agggtaatgt cagt~acagga aaaaaactgt gcaagtgagc 1700 acctgattcc gttgccttgc ttaactctaa agctccatgt. cctgggccta 1750 aaatcgtata aaatctggat tt:tt_tttttt tttt.ttgctc: atattcacat 1800 atgtaaacc.a gaacattcta tgtactacaa acctggtttt taaaaaggaa 1850 ctatgttgct atgaattaaa cttgtgtcat gctgatagga cagactggat 1900 ttttcatatt tcttattaaa attt=ctgcca tttagoagaa gagaacteac:a 1950 ttcatggttt ggaagagata aacc:tgaaaa gaagagtggc catat.ctt<:a 2000 ctt:tatcgat aagtcagttt attT_gtttc:a ttgtgtacat ttttatattc 2050 tccttttgac attataactg ttggcttttc taatcttgtt aaatatatct 2100 att.tttacca aaggtattta atattctttt ttatgacaac ttagatcaac 2150 tatttttagc ttggtaaatt tttct.aaac:a c;aattcxttat agccagagga 2200 acaaagatga tataaaatat tgttgctctg acaaaaatac atgtatttca 2256 ttctcgtatg gtgctagagt tagattaarc tgcattttaa aaaa<:tgaat 2300 tggaatagaa ttggtaagtt gcaaagac't. r_tt.gaaaata attaaattat 2350 catatcttcc attcctgtta ttggagatga aaataaaaag caacttatga 2900 aagtagacat tcagatccag ccattactaa cctattcctt ttttggggaa 2450 atctgagcct agctcagaaa aac:ataaagc accttgaaaa agacttgaca 2500 gcttcctgat. aaagcgtgct gtgctgtgca gtaggaacac atcctattta 2550 ttgtgatgtt gtggttttat tatcttaaac tctgttccat acacttgtat 2600 aaatacatgg atatttttat gtacagaagt atgtctctt:a accagttcac 2650 ttattgtact ctggcaattt aaaagaaaat c:agtaaaata ttttgctrgt. 2700 aaaatgctta atatngtgcc taggttatgt ggtgactatt. tgaatcaaaa 2750 atgtattgaa tcatc:aaata aaagaatcatg gctattttgg ggagaaaatt 2800 aaaaaaaaaa aaaaaaaaaa aggtttaeXgg ataacagggt aatgcggcc 2849 <210> 988 <211> 395 <212> PRT
<213> Homo sapiens <400> 988 Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly Gln Arg Gl.n Gly Thr Gln Al.a Glu Ser Asn L~eu Ser Sex Lys Phe Gln Phe Ser Ser Asn Lys Glu Gin Asn Gly Val Gln Asp Pro Gln His Glu Arg Ile Ile Thr Val Ser Thr Asn Gly Ser Ile His Ser 50 55~ 60 Pro Arg Phe Pro His Thr Tyr Fro Arg F,sn Thr Val Len Val Trp 32 ?

Arg Leu Val Ala Val Glu Glu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Gly Leu Glu Asp Pro Glu Asp Asp Ile C.:ys Lys 95 :00 105 Tyr Asp Phe Val Glu Val Glu Glu Pro Ser Asp Gly Thr ~7.e Leu Gly Arg Trp Cys Gly Ser Gly Thr Val Prc Gly Lys Gln ~le Ser Lys Gly Asn Gln Ile Arg I.ie Arc: Phe Val Ser Asp Glu '"yr Phe 7_40 145 150 Pro Ser Glu Pro Gly Phe Cys Ilc Hip: Tyr Asn .Lle Val Met Pro Gln Phe Thr Glu Ala Val Ser Pr~~ Ser Val Leu Pro Pro Ser Ala 170 17'=: 180 Leu Pro Leu Asp Leu Leu Asn Asn Ala Ilt~ Thr Al.a Phe Ser Thr Leu Glu Asp Leu Ile Arg Tyr Le.x Glu Pro Glu Arg Trp Gln Leu Asp Leu Glu Asp Leu Tyr P.ra, Pr~:~ Thr Trp Gln Leu Leu Gly Lys Ala Phe Val Phe Gly Arg Lys Ser Arg Val Val Asp Leu Asn Leu Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe Ser Val Ser Ile Arg Glu Glu Leu Lys Arg Thr Asp Thr Ile Phe 260 26w 270 Trp Pro Gly Cys Leu Leu Val Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu His Asn Cys Asn Gnu C'ys G).n Cys Val Pro Ser Lys Val Thr Lys Lys Tyr His Glu Val Leu Gln Leu Arg Pro Lys Thr 305 3:10 315 Gly Val Arg Gly Leu His Lys Ser Leu Thr Asp Val Ala lieu Glu 32.0 3:% 5 330 His His Glu Glu Cys Asp Cys Val Cys Arg Gly Ser Thr Gly Gly <210> 489 <211> 21 <212> DNA
<213> Artificial <220%
<221> Artificial Sequence <222> 1-21 <22.3> Artificial Sequence <400> 989 acttctcagt gtccataagg g 27 <210> 490 <211> 40 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <'Z22> 1-4G
<223> Artificial Sequence <400> 490 gaactaaaqa gaaccgat=ac cattttctgg c:cagg~tgtc 40 <210> 491 <211> 20 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-20 <223> Artificial Sequence <900> 991 caccacagcg tttaaccagg 20 <210> 492 <211> 20 <212> DNA
<213> Artificial <220>
<:221> Artificial Sequence <222> 1-20 <223> Artificial Sequence <400> 49~:
acaacaggca cagttcccac 20 <210> 493 <211> 21 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> l-21 <223> Artificial Sequence <400> 993 ggcggaatcc aacctgagta g 21 <210> 494 <211> 20 <212> DNA
<213> Artificial <220>

<221> Artifir_ial Sequence <222> 1-20 <223> Artificial Sequence <400> 494 gcggctatcc tcctgtgctc 20 <210> 995 <211> 3283 <212> DNA
<27.3> Homo sapiens <900> 995 cccatctcaa gctgatcttg gcacctctca tgctc~=gctc tcttcaacca 50 gacctctaca ttccattttq gaagaagac~t aaaaatggtg tttccaatgt 100 ggacactgaa gagacaaatt ctt:atccttt ttaac._itaat cctaatttcc 150 aaactccttg gggctagatg gtttcctaaa act:ctgccct gtgatgtcac 200 tctggatgtt ccaaagaacc atgtgatcgt. qgactgcaca gacaagcatt 250 tgacagaaat tcctggaggt attcccacga acaccacgaa cctcaccctc 300 accattaacc acataccaga catctcccca gcgtcctttc acagactgga 350 ccatctggta gagatcgatt tcagatgcaa ctgtgtacct attccact::gg 400 ggtcaaaaaa caacatgtgc atcaagaggc t.gcacattaa accc.agae3gc 450 tttagtggac tcacttattt aaaatccc:tt taco ggatg gaaaccagct 500 actagagata ccgcagggcc t.cccgcctag cttac:agctt ctcagccttg 550 aggccaacaa catcttttcc atcagaaaag agaatctaac agaactggcc 600 aacatagaaa tactctacct gggccaaaaac tgttattatc gaaatccttg 650 ttatgtttca tattcaatag agaaagatgc cttcctaaac ttgacaaagt 700 taaaagtgct ctccctgaaa gataaca,-atg tcacagccgt ccctaca gtt 750 ttgccatcta ctttaacaga actatat_etc taca,scaaca tgattgcaaa 800 aatccaagaa gatgatttta ataacct.~.a~ ccaattacaa attcttgacc 850 taagtggaaa ttgccctcgt tgLtataatg c<:ccatttcc ttgtgcgccg 900 tgtaaaaata attctcccct acagatccct gtaaatgctt ttgatgc:gct 950 gacagaatta aaagttttac gtctacacag t<~actctctt: cagcatgtgc 1000 ccccaagatg gtttaagaac atcaacaaac tccaggaact: ggatctgtcc 1050 caaaacttct tggccaaaga aatt=ggggat gctaaatttc: tgcattttct 1100 ccccagcctc atccaattgg atctgtcttt caattttgaa cttcaggtct 1150 atcgtgcatc tatgaatcta tcacaagcat. tttcatcact: gaaaagcctg 1200 aaaattctgc ggatcagagg atatgtcttt aaagagttga aaagctttaa 1250 cctctcgcca ttacataatc ttcaaaatct tgaagttctt gatcttggca 1300 ctaactttat aaaaattgct aaci:tcagc:a tgtttaaaca atttaaaaga 1350 ctgaaagtca tagatctttc agtc~aataaa atatcacctt caggagatt:c 1900 aagtgaagtt ggcttctgct caaatgccag aacttctgta caaaagttata 1450 aaccccaggt cctggaacaa tta;-attatt tcagat:atga t=aagtatgca 1500 aggagttgca gattcaaaaa caaagaggca. tcttteatgt ctgttaatga 1550 aagctgctac aagtatgggc agaccttgc~a tctaagtaaa aatagtat,at 1600 tttttgtcaa gtcctetgat tttcagcatc t.ttctttcct caaatgcctg 1650 ,satctgtcag gaaatctc:at tagccaaact: cataarggca gtgaattcca 1700 acctttagca gagctgagat att.tggactt ctr.:caacaac cggcttgatt 1750 tactccattc aacagcattt gaagagcttc acaaactgga agttctggat 1800 ataagcagta atagccatta ttttcaatca gaaggaatta ctcatatgct 1850 aaactttacc aagaacctaa aggttctgca gaaactgatg atgaacgaca 1900 atgacatctc ttcctccacc agcaggacca t:ggagagtga gtctcttaga 1950 actctggaat tcagaggaaa tcact_tagat gttttatgga gagaaggtga 2000 taacagatac ttacaattat t.caagaatct gctaaaatta gaggaatt=ag 2050 acatctctaa aaattcccta agtttcttgc ct=tctggagt ttttgatg gt 2100 atgcctccaa atctaaagaa tctctctttq gccaaaaatg ggctcaaatc 2150 tttcagttgg aagaaactcc agtgtctuaa gaacct:ggaa actt:tggacc 2200 tcagccacaa ccaactgacc actgtccc;tg agagatt.atc caactgttcc 2250 agaagcct.ca agaatctgat tcttaagaat aatcaaatca ggagtctgac 2300 gaagtatt.tt ctacaagatg cct.tccagtt gcgaratctg gatctcagct 2350 caaataaaat. ccagatgatc caaaagac:ca gctt.cccaga aaatgtcctc 2400 aacaatctga agatgttgct tttgcatcat. aatcggtttc tgtgcacctg 2450 tgatgctgtg tggtttgtct ggtgggttaa c:c:atacggag gtgactattc 2500 cttacctggc cacagatgtg acttgtgtgg ggccaggagc acacaagggc 2550 caaagtgtga tctccctgga tctgtacacc tgtgagttag atctgacaaa 2600 cctgattctg ttctcacttt cc:atatctgt atctctcttt ctcatggtga 2650 tgatgacagc aagtcacctc tatttctggg atgtgtggta tatttaccat 2700 ttctgtaagg ccaagataaa ggggtatcag cgtctaatat caccagactg 2750 ttgctatgat gctttt.attg tgtatgacac t;aaGgaccca gctgtgaccg 2800 agtgggtttt ggctgagctg gt:ggccaaac tggaagaccc aagagacXaaa 2850 3 z1 cattttaatt tatgtctcga ggaaagggac tggttaccag ggcagccagt 2900 tctggaaaac ctttcccaga gcatacagct tagcaaaaag acagtgttt:g 2950 t.gatgacaga caagtatgca aagactgaaa attttGagat a:zgcat.tttac 3000 ttgtcccatc agaggctcat ggatgaaaaa gttgat.gtga ttatcttgat 3050 atttcttgag aagccc:tttc agaagtccaa gttcctccag ctccggaaaa 3100 ggctctgtgg gagttctgtc cttgagtgcxc caaca<iaccc: gcaagctcac 3150 ccatacttct ggcagtgtct. aaagaacgcc ctggccac.ag ac:aatcatgt 3200 ggcctatagt caggtgttca aggaaacg<Xt ctagcccttc tttgcaaaac: 3250 acaactgcca agtttaccaa ggagaggcc;t ggc 3:?83 <210> 496 <211> 1049 <212> PRT
<213> Homo sapiens <400> 496 Met Val Phe Pro Met Trp Thr Leu Lys Arg Gln Ile Leu Ile Leu Phe Asn Ile I.le Leu Ile ;:>er Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys Thr Leu Pro Cys hasp Val Thr Leu Asp Val Pro Lys Asn His Vai Ile Val Asp <.'ys Thr A:~p hys His Leu Thr Glu Ile Pro Gly Gly Ile Pro Thr Asn Th,r Ttar Asn Leu Thr Leu Thr Lle Asn E~5 ''0 75 His Ile Pro Asp Ile Ser Pro A:la Ser Phe His Arg Leu Asp His Leu Val Gl.u Ile Asp Phe Arg Cys Asn Cys Val I'ro Ile Pro Leu Gly Ser Lys Asn Asn Met Cys Ile Lys Arg Leu Gln Ile Lys Pro 1i0 115 720 Arg Ser Phe Ser Gly Leu Thr T;,,~r Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu Ile Fro Gln Gly heu Pro Prc: Ser Leu Gln Leu Leu Ser Leu Glu Ala Asn Asn Ile Fhe Ser Ile Arg Lys Glu Asn Leu Thr Glu Leu A_a A,sn Ile Clu IlE: Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Z'yr Val Ser Tyr Ser Ile 1s5 190 195 Glu Lys Asp Ala Phe Leu A~.n Leu Thr Lys Leu Lys Val Leu Ser 200 a?05 210 Leu Lys Asp Asn Asr~ Val Thr Ala Val Pro Thr Val Leu Pro Ser 2:L'_v 220 225 Thr Leu Thr Glu Leu Tyr LF>a Tyr Asn Asn Met Ile Ala Lys Ile Gln Glu Asp Asp Phe Asn Asn Leu Asn Gln Leu Gln Ile Leu Asp 29 ~: 250 255 Leu Ser Gly Asn C;ys Pro Arg Cya Tyr Asn Ala Pro Phe Pro Cys 260 26'.i 270 Ala Pro Cys Lys Asn Asn Ser Prc> Leu Gln Ile Pro Val Asn Ala Phe Asp Ala Leu Thr Glu heu Ly:> Val Leu Arg Leu His Ser Asn Ser Leu Gln His Val Pro Pr.o Arg Trp Phe Lys Asn Ile Asn Lys Leu Gln Glu Leu Asp Leu Ser Gln Asn Phe Leu Ala Lys Glu Ile Gly Asp Ala Lys Phe Leu His Phe Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe Glu Lea Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val Phe Lys Glu Leu Lys Ser Phe Asn Leu Ser Pro Leu Hi.s Asn Leu c~ln A;n heu G7a Val Leu Asp Leu Gly Thr Asn Phe Ile Lys Ile Ala A:=n Leu Ser Met. Phe Lys Gln Phe 470 9:.5 420 Lys Arg Leu Lys Val :Ile Asp Le:u Ser V<~1 Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu Val Gay F'he Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Giu Pro Gln Val Leu Glu Gln Leu His Tyr Phe Arg Tyr Asp Lys Tyr Ala Arg Ser Cys Arg Phe Lys Asn Lys Glu Ala Ser Phe Met Ser Val Asn Glu Ser Cys Tyr Lys Tyr Gly Gln Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Phe Val Lys Ser 500 50_'. 510 Ser Asp Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu Ile Ser Gln Thr Leu Asn Gly Ser Cilu Phe Gln Pro Leu Ala Glu Leu Arg Tyr Leu AsF; Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr Ala Phe Glu Glu Leu His Lys Leu Glu Val 560 56'. 570 Leu Asp Ile Ser Ser Asn Ser Hip. T,rr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr Ly;: Asn Leu Lys Val Leu Gln Lys 590 59~ 600 Leu Met Met. Asn Asp Asn Asp Ile Ser Ser Ser Thr Ser Arg Thr Met Glu S'er Glu Ser Leu Arg Thr Leu Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Glu Gly Asp Asn Arg Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys I~eu Glu G1u Leu Asp Ile Ser Lys Asn Ser Leu Ser Phe Leu Pro Ser Gly 'Jal Phe Asp Gly Met. Fro Pro Asn Leu Lys Asn Leu Ser Leu Ala Lys Asn Gly L~eu Lys Ser Phe Ser Trp Lys Lys Leu Gln Cys LE:~u Lys Asn Leu Glu Thr Leu Asp Leu Ser His Asn Gin Leu Thr Thr Val Pro Glu Arg Leu Ser Asn 710 7'15 720 Cys Ser Arg Ser Leu Lys Asn Leu Ile Leu Lys Asn Asn Gln Ile Arg Ser Leu Thr Lys Tyr I'he Leu Gln Asp Ala Phe Glr: Leu Arg Tyr Leu Asp Leu Ser Ser Asn Lys Ile G.ln Met :Ile Glr: Lys Thr Ser Phe Pro Glu Asn Val Leu Asn Asn Leu Lys Met Leu Leu Leu His His Asn Arg Phe Leu Cys Thr Cys A.sp Ala Val Trp Phe Val Trp Trp Val Asn His Thr Glu Val Thr Ile Pro Tyr Leu Ala Thr Asp Val Thr Cys Val Gly Pro Cly Ala His Lys Gly Gln Ser Val 3:39 Ile Ser Leu Asp Leu Tyr Thr Cys Glu Leu Asp heu Thr Asn Leu 830 83'. 890 Ile Leu Fhe Ser Leu Ser Lle Ser Val Ser Leu Phe Leu Met Val 895 85C) 855 Met Met Thr Ala Ser His Leu Tyr Phe Trp Asp Val Trp 'Iyr Ile Tyr His Phe Cys Lys Ala hys Ile Lys Gly 'I'yr Gln Arg Leu Ile 875 88~) 885 Ser Prc Asp Cys Cys Tyr Asp Ala Phe I1~~ Val Tyr Asp Thr Lys Asp Pro Ala Val Thr Glu 'I'rF: Va1 Leu Ala Glu Leu Val Ala Lys 905 91(7 915 Leu Gl.u Asp Pro Arg Glu Ly:; His Phe Asn Leu Cys Leu Glu Glu Arg Asp Trp Leu Pro Gly C=In Fro Val Leu Glu Asn Leu Ser Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys 950 95.5 960 Tyr Ala Lys Thr Glu Asn Phe Lys Ile Ala Phe Tyx Leu Ser His 965 9;0 975 Gln Arg Leu Met Asp Glu Lys Val Asp Val Ile Ile Leu Ile Phe Leu Glu Lys Pro Phe Gln L,ys SE>r Lys Phe Leu Gln Leu Arg Lys Arg Leu Cys Gly Ser S'er Val Lr:u Glu T:~p Pro Thr Asn Pro Gln Ala His Pro Tyr Phe Trp Gln Cys Leu Lys Asn Ala Leu Ala Thr Asp Asn His Val Ala Tyr Ser Gln Val. Phe Lys Glu Thr Val <210> 99'7 <211> 4199 <212> DNA
<213> Homo sapiens <400> 997 gggtaccatt ctgcgctgct gcaagttacg gaatgaaaaa ttagaac:aac 50 agaaacatgg aaaacatgt.t cc:ttcagtcg tcaa.tgctga cctgcatttt 100 cctgctaata tctggttcct gtgagttatg cgcc:gaagaa aatttttcta 150 gaagctatcc ttgtgatgag aaaaagcaaa atgactcagt tattgcagag 200 tgcagcaatc gtcgactaca ggaagttccc caaacggtgg gcaaatatgt 250 gacagaacta gacctgtctg ataatttcat cacacacata acgaatgaat 300 3a5 catttcaagg gctgcaaaat ctcactaaaa taaatctaaa ccacaacccc 350 aatgtacagc accagaacgg aaatcccggt atacaat::aa atggcttgaa 900 tatcacagac ggggcattcc tcaacctaaa aaacctaagg gagttactgc 950 ttgaagacaa ccagttaccc caaataccct c:tggtttgcc agagtctttg 500 acagaactta gtctaattca aaacaatata tacaacataa ctaaagagg g 550 catttcaaga cttataaact tgaaaaatc:t ctatttggcc tggaactgct 600 attttaacaa agtttgcgag aaaactaac_a t.agaa<aatgg agtatttgaa 650 acgctgacaa atttggagtt gctat.cact_a t:ctttcaatt ctctttcaca 700 cgtgccaccc aaactgccaa gct:ccctas:g caaacttttt ctgagcaaca 750 cccagatcaa atacattagt gaagaagatt tc:aagggatt gataaattta 800 acattactag atttaagcgg gaactgtc;,g aggtgcttca atgccccatt 850 tccatgcgtg ccttgtgatg gtggtgcttc aattaatata gatcgttttg 900 cttttcaaaa cttgacccaa cttcgataac taaacctctc tagcacttcc 950 ctcaggaaga ttaatgctgc ctggtttaaa aatatgcctc atctgaaggt 1000 gctggatctt gaattcaact atttagtggg agaaatagt:c t.ctggggc_at 1050 ttttaacgat gctgccccgc: ttagaaatac ttgacatgtc ttttaacr_at 1100 ataaagggga gttatccaca gcatattaat atttc:cagaa acttctct=aa 1150 acttttgtct ctacgggcat tgc~atttaag aggttatgtg ttcc:aggaac 1.200 tcagagaaga tgatttccag cccctgat;gc agctt:ccaaa ctt:atcgar_t 1250 atcaacttgg gtattaattt. tattaag<:aa atcga tttca aactt.ttcca 1300 aaatttctcc: aatctggaaa ttatttartt gtcagaaaac agaatatcac 1350 cgttggtaaa agatacccgg c:agagtt«tg caaa-agtt.c ctcttttcaa 1900 cgtcatatcc ggaaacgacg ctcaaca<:lat tttgagtttg acccacattc 1450 gaacttttat catttcaccc gtcctttr~at aaagccacaa tgtgctgctt 1500 atggaaaagc cttagattta agcctcaaca gtattttctt cattgggcca 1550 aaccaatttg aaaatcttcc tgacattc~cc tgtttaaatc tgtctgcaaa 1600 tagcaatgct caagtgttaa gtggaacrga attttcagcc attcctc:atg 1650 tcaaatattt ggatttgaca aacaatag ac tagactttga taatgctagt 1700 gctcttactg aatt.gtccga ctt.ggaagtt ctagat:ctca gctataattc 1750 acactatttc agaatagcag gc:gtaacaca tcatctagaa tttattcaaa 1800 atttcacaaa tctaaaagtt ttaaacttga gccacaac:aa catttatact 1850 ttaacagata agtataacct ggaaagcaag tccctggtag aattagtttt 1900 cagtggcaat cgccttgaca tttt.gtggaa tgatgatgac aacaggtai=a 1950 tctccatttt caaaggtc:tc aagaatctca cacgtc:tgga t:ttatccct=t 2000 aataggctga agcacat<:cc aaatgaag<°a ttcctt.aatt tgccagcgag 2050 tctcactgaa ct.acata~.aa atgataatcat gttaaagttt tttaactgga 2100 cattactcca gcagttt<~ct cgtctcgaqt t.gcttc~actt acgtggaaac 2150 aaactactct ttttaacvga tagcctatut gactt_acat cttccctt~~g 2200 gacactgctg ctgagtcata acaggatttc c:cacct:accc tctggctttc 2250 tttctgaagt cagtagt~tg aagcacctcg attta.3gttc caatctgcta 2300 aaaacaatca acaaatc:~gc act:tgaaa<:t aagaccacca ccaaattatc 2350 tatgttggaa ctacacggaa acc:cctttga atgcacctgt gacattggag 2400 atttccgaag atggatggat gaacatctga atgtcaaaat tcccagaca g 2950 gtagatgtca tttgtgccag tcctggggat caaagaggga agagtattgt 2500 gagtctggag ctaacaactt gtgtttcaga tgtcactgc:a gtgatattat 2550 ttttcttcac gtt.ct.ttatc acwaccatgg ttatgttggc t.gccctgqct 2600 caccatttgt tttactqgga tgi:.ttggttt at=atGtaata tgtgtttagc 2650 taaggtaaaa ggctacaggt ct<attcc,ac at_ccc:aaact ttctat.g<3tg 2700 cttacatttc t:tatgac:acc aaaagatgc;ct ctgtt:actga ctgggtgata 2750 aatgagctgc gctacc<:cct tgaag agagc cgagacaaaa acgt:tctc~ct 2800 ttgtctagag gagaggc~att gg:~accccrgg attggccatc atcgacaacc 2850 tcatgcagag catcaaa:.caa agc:aagaaaaa cagtatttgt to taaccaaa 2900 aaatatgcaa aaagctc:~gaa ctttaaa,::~ca gctt~ttact tggctttgca 2950 gaggctaatg gatgagaaca tggatgt::tat t.atatttatc ca gctggagc 3000 cagtgttaca gcattctcag tatttgaggc tacggcagcg gatctgtaag 3050 agctccatcc tccagt:xgcc tgacaacccg aaggcagaag gcttgttttg 3100 gcaaactctg agaaatgtgg tc:ttgact,:ga aaatgattca cggtataaca 3150 atatgtatgt cgattccatt. aagc;aat3ct aactgacgtt aagtcatgat 3200 ttcgcgccat aataaagatg caaaggaatg acatttctgt attagttatc 3250 tattgctatg taacaaatta tcccaaaact. tagtggtt.ta aaacaacaca 3300 tttgctggcc cacagttttt gagggtcagg agtccaggcc cagcataact 3350 gggtcctctg ctcagggtgt ctca gaqgct gcaa.tgtagg tgttcaccag 3400 agacataggc atcactgggg tcacactcat gtggtt.gttt tctggattca 3450 3 3'7 attcctcctg ggctattagc caaaggctat actcatgt.aa clccat.gcgag 3500 cctc:tcccac aaggcagcat gct.tc~atcug agctagcaaa aaagagaggt: 3550 tgctagcaag atgaagt<:ac aat~~ttttgt aatcgaatca aaaaagtgat 3600 atctcatcac tttggccata t.tctatttrt tagaagtaaa c cacaggtcc 3650 caccagctcc atgggagtga cca~~ctca~xt_ ccagggaaaa cagc~gaaga 3700 ccaagatggt gagctctgat tgct=tcagt_t ggtcatcaac tattttccct 3750 tgactgctgt cctgggatgg cctgctat~.t tgatgataga ttgtgaatat 3800 caggaggcag ggatcactgt ggaccatc-:.t agcagttgac ctaacacatc 3850 ttcttttcaa tatctaagaa ctttt.gccac tgtgactaat ggtcctaata 3900 ttaagctgtt gtttatattt atc:atata_c tatggctaca tggttatatt 3950 atgctgtggt tgcgttcggt tttattta~~a gttgctttta caaatatttg 4000 ctgtaacatt tgacttctaa ggttt:agatg ccatttaaga actgagatgg 4050 atagctttta aagcatcttt tacttcttac cattttttaa aagtatgcag 9100 ctaaattcga agcttttggt ctatattatt aattciccatt gctgtaaatc 4150 ttaaaatgaa tgaataaaaa tgt:ttcattt tacaaaaaaa aaaaaaaaa 4199 <210> 498 <211> 1041 <211> PRT
<213> Homo Sapiens <400> 998 Met Glu Asn Met Phe Leu Gln Seer Ser Met Leu 'Phr Cys Ile Phe Leu Leu Iie Ser GLy Ser Cys GLu Leu Cys Ala Glu Glu Asn Phe Ser Arg Ser Tyr Pro Cys Asp G::u Lys Lys Gln Asn Asp Ser Val Ile Ala Gl.u Cys Ser Asn Arg A~g Leu Gln Glu Val Prc: Gln Thr Val Gly Lys I'yr Val Tpr Glu I:eu Asp Leu .'per Asp Asr. Phe Ile Thr His Ile Thr Ian Glu Ser Fhe Gln Gly Lei:c Gln Asn Leu Thr 80 8'_> 90 Lys Ile Asn Leu Issn His Asn Prc Asn Val Gln His Gln Asn Gly Asn Fro Gly Iie C~ln Ser Asn C;ly Leu Asn lle Thr Asp Gly Ala 1G 7.15 120 Phe Leu Asn Leu ,ys Asn Leu Arg Glu Leu Leu Leu Glu Asp Asn .25 i30 135 Gln Leu Pro Gln Ile, Pro Ser Gly Leu Pr<> Giu Ser Leu Thr Glu 29(i 195 150 Leu Ser Leu Ile Glr: Asn Asn IlE:~ Tyr Asn 11e 'Phr Lys !.1u Gly 15', 160 165 Ile Ser Arg Leu Iie Asn Leu Ly:: Asn Leu Tyr -~,eu Ala '1'rp Asn 17-'0 17!~ 180 Cys Tyr Phe Asn Ly:~ Val Cys Gl~.i Lys Th:r Asn Ile Gl.u Asp Gly 18 ~ 190 195 Val Phe Glu Thr Le.1 Thr Asn Leu Glm Lev Leu Ser Leu Ser Phe Asn Ser Leu Ser His 11a1 F'ro Pro Lys Leu Pro Ser Ser Leu Arg Lys Leu Phe Leu Ser Asn Thr Gln ile Lys 'Iyr Ile Ser Glu Glu Asp Phe Lys Gly Leu Il.e Asn Le..z Thr Leu Leu Asp Leu Ser Gly Asn Cys Pro Arg Cys Phe Asn Ala Pro Phe Pro Cys Val Pro Cys 2E.0 265 270 Asp Gly Gly Ala Ser Ile Asn Iie Asp Arg Phe Ala Phe Gln Asn 2''5 280 285 Leu Thr Gln Leu Ax g Tyr Leu As n L,eu Ser Ser T'hr Ser Leu Arg 2~a0 2~)5 300 Lys Ile Asn Ala Aa Trp Phe L;s Asn Met Pro His Leu Lys Val 3 .t5 3:1 0 315 Leu Asp Leu Glu Phe Asn Tyr Lf~u Val G:Ly Glu I:le Val 5er Gly 3:?0 3:'S 330 Ala Phe Leu Thr M~=t :Leu Pro A.cg Leu Glu Ile heu Asp Leu Ser Phe Asn Tyr Ile Lys Gly Ser Tyr Pro G1n His Ile Asn Ile Ser 350 3'i5 360 Arg Asn Phe Ser hys Leu Leu Ser Leu Arg Ala Leu His Leu Arg 365 370 3'75 Gly Tyr Va1 Phe Gln Glu Leu Arg Glu Asp Asp Phe Gln Pro Leu Met Gln Leu Pro P~sn Leu SE:r T:lr Ile Asn Leu Gly I1e Asn Phe Ile Lys Gln Ile F~.sp Phe Lys L.eu Phe Gln Asn Phe Ser Asn Leu Glu Ile Ile Tyr Leu Ser Glu Asn Arg Ile Ser Pro Leu Val Lys ~25 X30 435 Asp Thr Arg Gln Ser Tyr A.la Asn Ser Ser Ser Phe Gln Arg His 3 :3 9 Ile Arg Lys Arg Arc Ser Thr Asp Phe Glu Phe Asp Pro f'is Ser 95' 460 465 A.sn Phe Tyr His Phe Thr Arg Pro Leu Tle hys Pro Gln C.ys Ala 9'7C~ 475 480 Ala Tyr Gly Lys AlaLeu A;~p LeL; Ser Leu Asn Ser Ile Phe Phe 98~ 990 495 Ile Gly Pro Asn Glr~ Phe GLu Asr~ Leu Prc> Asp 1e Ala Cys Leu Asn Leu Ser Ala Asri Ser Asn Ala Gln Va-~ Leu Ser Gly T hr Glu 51'~ 520 525 Phe Ser Ala Ile Pr~; His Val Ly:: Tyr Leu Asp Leu Thr Asn Asn 530 53'._590 Arg Leu Asp Phe Asp Fa n Ala SeA1a Len Thr Glu Leu Ser Asp 545 55~ 555 Leu Glu Val Leu Asp Leu Ser Tyr Asr~ Ser His Tyr Phe Arg Iie Ala Gly Va.L Thr His His Leu Glu Phe Ile Gln Asn Phe Thr Asn 5'75 580 585 Leu Lys Val Leu Asn Leu :ver Hi:; Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu Ser Lys Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp Ile Leu Trp Asn Asp Asp Asp Asn Arg 6a:0 6~ 5 630 Tyr Ile Ser Ile Pte Lys Gly Leu Lys A:;n Leu Thr Arg Leu Asp 6;s5 64:0 695 Leu Ser Leu Asn A.-g Leu Lys His Ile Pno Asn Glu Ala Phe Leu 6'.'.0 6.'i5 660 Asn Leu Pro Ala Ser Leu 'I'thr Giu Leu H=~s Ile Asn Asp Asn Met 6~~5 6'J0 675 L~eu Lys Phe Phe Asn Trp Thr Lf.:~u I:eu G.Ln Gl.n F'he Pro Arg Leu 6r30 685 690 Glu Leu Leu Asp Leu Arg G'ly Ann Lys Leu Leu I'he Leu Thr Asp Ser Leu Ser Asp Phe Thr Ser Ser Leu Arg Thr Leu Leu Leu Ser His Asn Arg Ile Ser His Le~u P:.o Ser Gly Phe L,eu Ser Glu Val Ser Ser Leu Lys His Leu Asp Leu Ser Ser Asn L,eu L,eu Lys Thr Ile Asn Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser '.~55 760 765 Met Leu Glu Leu His Gly Asn Prc: Phe Glu Cys Thr Cys Asp Ile 77C: 775 780 Gly Asp Phe Arg Arc; Trp Met Asp Glu Hip; Leu Asn Val ':~ys Ile 78w, 790 795 Pro Arg Leu Val Asp Val Ile CyAla Ser Fro C~ly Asp Gl.n Arg Gly Lys Ser Ile Vai Ser Leu Glu Leu Thr Thr Cys Val Ser Asp 81~ 820 825 Val Thr Ala Val Ile Leu Phe Pht~ Phe Th:. Phe Phe Ile Thr Thr 83 7 83:, 890 Met Val Met Leu Ala Ala L,eu A1=3 His Hi.s Leu Phe Tyr Trp Asp Val Trp Phe Ile Tyr Asn Val Cys Leu Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr Ser C:ln Thr Phe Tyr Asp Ala Tyr Ile Ser Tyr Asp Thr Lys Asp Ala Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu Glu Glu Ser Arg Asp Lys Asn Val Leu Leu 9C~5 910 915 Gys Leu Glu Glu Arg Asp Trp Asp Pro Gly Leu Ala Ile Ile Asp 9a 0 925 930 Asn Leu Met Gln SEr Ile Asn Gln Ser Lys Lys Thr Val Phe Val 9.'-,5 940 945 Leu Thr Lys Lys Tyr Ala L~ys SE_r Trp Asn Phe Lys Thr Ala Phe Tyr Leu Ala Leu Gin Arg Leu Met Asp G:Lu Asn Met Asp Val Ile Ile Phe Ile Leu Leu Glu Pro V~~l lieu Gln His Ser Gln Tyr Leu Arg Leu Arg Gln Arg Ile Cys Lys Ser Ser Ile Leu Gln Trp Pro Asp Asn Pro Lys A1a Glu Gly Leu Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr C~lu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile Lys Cln Tyr <210> 499 <21.1> 20 <212> DNA
<2i3> Artificial, <220>
<221> Artificial Se<~uence <222> 1-2O
<223> Artificial Sequence <400> 499 taaagaccca gctgtgaccg 20 <21U> 500 <211> 20 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-c:0 <223> Artificial Sequence <900> 500 atccatgagc ctctgatggg 20 <210> 501 <211> 45 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-45 <22's> Artificial Sequence <400> 501 atttatgtct cgaggaaagg gactggtt:ac caggclcagcc agttc 45 ':210> 502 ~:211> 21 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-21.
<223> Artificial Sequence <400> 502 gccgagacaa aaacgttctc c 21 <210> 503 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial .equencE>
<222> 1-24 <223> Artificial 6equencc,e <400> 503 catccatgtt ctcatc-catt agc~~ 2~i <210> 504 <211> 96 <212> DNA
3q2 <213> Artificial.
<220>
<221> Artificial Sequence <222> 1-96 <223> Artificial Sequence <900> 504 tcgacaacct catgcagagc atcaacca~:a gcaagaaaac agtatt 9n <210> 505 <211> 1738 <212> DNA
<213> Homo sapiens <900> 505 ccaggtccaa ctgcacctcg gttctatc<xa t:tgaattccc cggggatcct 50 ctagagatcc ctcgacctcg acccacgcgt ccgccaagct gg ccctgcac 100 ggctgcaagg gaggctc:ctg tggac:agg::;c aggcaggtgg gcctcaggag 150 gtgcctccag gcggccagtg ggcctgaggc cccagcaagg gctagggtcc 200 atctccagtc ccaggacaca gcagcggcca c:catggccac gcctgggctc 250 cagcagcatc agcagccccc agc;ar_cgggg aggcocaggt ggcccccacc 300 acccggagga gcagctc:ctg cccc~gtccg ggggatgact gattctcct.c 350 cgccaggcca cccagaggag aaggccac:cc cgcct:ggagg cacaggcc;at 900 gaggggctct caggagcltgc tgctgatc,;tg gcttc:tggtg t.tggcagt_gg 450 gcggcacaga gcacgcca ac cggcccgc;cc, gtagggtgtg tgctgtccgg 500 gctcacgggg accctg~:.ctc cgagtcgttc. gtgc<sgcgtg t.gtaccagcc 550 cttcctcacc acctgc~yacg ggcaccgggc Ctgcagcacc taccgaacca 600 tctataggac cgccta~~cgc cgcagcc<:tg ggct~3gcccc tgccaggcct 650 cgctacgcgt gctgccccgg ctggaag<agg accagcgggc t~tcctggggc 700 ctgtggagca gcaatatgcc agccgcc;atg ccggaacgga gggagctgtg 750 tccagcctgg ccgctg:~cgc tgcc:ctgcag gatggcgggg tgacacttgc 800 cagtcagatg tggatgaatg cagtgct<xgg aggggcggct gtccccagcg 850 ctgcatcaac accgc:cggca gttactggtg ccagtgttgg gaggggcaca 900 gcctgtctgc agacggtaca ctctgtgtgc ccaagggagg gccccccagg 950 gtggccccca acccgacagg agtggacagt gcaatgaagg aagaagtgca 1000 gaggctgcag tccagc;gtgg acctgctgga ggagaagctd cagctgc,~tgc 1050 tggccccact gcacaccctg gcctcgc:agg cact:ggagca tgggctcccg 1100 gaccccggca gcctcc: tggt gcactcc:ttc cagc:agctcg gccgcatcga 1150 ctccctgagc gagcac;attt ccttcctgga ggagcagctg gggtcctgct 1200 3~~3 cctgcaagaa agactcgtga ctgcc~~agc:g c:cccaggctg gactgagccc 1250 ctcacgccac cctgcagccc ccatgcccct gcccaa catg ctgggggt~Jc 1300 agaagccacc tcggggtgac tgagcggaag gccagc~cagg gc:cttcctcc 1350 tcttcctcct ccccttc:~tc gggaggctc:c c:cagaccctg gcatgggatg 1900 ggctgggatc ttctctgtga atccaccc~:t ggctaccccc accctggcta 1950 ccccaacggc atcccaaggc caggtgggc:c ctcag~~tgag ggaaggtacg 1500 agctccctgc tggagcctgg gacccatggc acaggccagg cagcccggag 1550 gctgggtggg gcctcagtgg gggctgctc~c ctgaccccca gcacaataaa 1660 aatgaaacgt gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1650 aaagggcggc cgcgact:cta gagtcgacct gc:agaagctt ggccgccatg 1700 gcccaacttg tttattgcag ctt:at:aatgg ttacaaat. 1738 <210> 506 <211:~ 273 <212PR';
<213> Homo sapiens <400> 506 Met Arg Gly Ser Gin C~lu Val Le:u Leu Met Trp Leu Leu Val Leu 1 5 =0 15 Ala Val Gly Gly Thr Glu His A-~;a Tyr Arg Pro Gly Arg Arg Val ..?0 25 30 Cys Ala Val Arg Aia His Gly A:-.p Pro Val Ser Glu Ser Phe Val ?5 90 95 Gln Arg Val Tyr GLn Pro Phe Le~u Thr Thr Cys Asp Gly His Arg '~0 =;5 60 Ala Cys Ser Thr Tyr Arg Thr Ite Tyr Arg Thr Ala Tyr A rg Arg Ser Pro Gly Leu Ala Pro Ala Aa:g Pro Arg Tyr Al.a Cys Cys Pro Gly Trp Lys Arg Thr Ser Gly Le a Pro Gly Ala Cys Gly Ala Ala Ile Cys Gln Pro Pro Cys Arg Asn ugly Gly Ser Cys Vas Gln Pro Gly Arg Cys Arg C'ys Pro Ala Gly Trp P,rg Gly Asp Thr Cys G1n Ser Asp Val Asp c:~lu Cys Ser Ala Arg Arg Gly Gly Cys Pro Gln .90 7.95 150 Arg Cys Ile Asn "'hr Ala Gly Ser Tyr Trp Cys Gln Cys Trp Glu S5 x.60 165 Gly His Ser Leu 'per Ala Asp C-'ly Thr l.;eu Cys Val Pro Lys Gly 3.~ 4 Gly Pro Pro Arg Val Al<3 Prro Asr, Pro Thr Gly Val Asp Ser A1a 18' 190 195 Met Lys G1u Glu Va: Gln Arg Leu Gl,n Ser Arg Val Asp Leu Leu <'0(~ 205 Glu Glu hys Leu Gln Leu Val Leu Ala Prc: Leu His Ser Leu Ala 2.1 ' 220 225 Ser Gln Ala Leu Glu His Gly Lei: Pro AsF> Pro Gly Ser Leu Leu 23 ) 235 290 Val His Ser Phe Gl:u Gln Leu G1;' Arg Ile Asp Ser Leu Ser Glu 29-~ 250 255 Gln Ile Ser Phe L,e~.a Glu Glu Gltc Leu Gly Ser Cys Ser Cys Lys Lys Asp Ser <210. 507 <211? 1700 212> DNA
<213~ Homo sapiens <400> 507 gccaggcagg tgggcctcag gaggtgcctc caggcggcca gtgggcctga 50 ggccccagca agggctaggg tccatctc.ca gtcccaggac acaacagc:gg 100 ccaccatggc cacgcctggg ctc:ca gce,gc atcagagcag cccca gtggt 150 tggcagcaaa gttcagottg gctgggccvcg ca gtc~agggg cttcgcgcta 200 cgccctgcgg tgtccc~Iagg gctgaggtct cctcatct.tc tccctagcag 250 tggatgagca acccaac;ggg ggcccggc.;ga ggggaactgg c:cccgaggga 300 gaggaacccc aaagccacat ctgtagccvag gatgagcagt gtgaatccag 350 gcagccccca ggaccgggga ggcacagcitg gcccccacca cccggaggag 900 cagctcctgc ccctgt~cgg gggatga::ta attctcctcc gccaggccac 450 ccagaggaga aggcca::ccc gcctggaggc acaggccatg aggggctctc 500 aggaggtgct gctgatgtg g cttc:tggt:,gt tggcagtggg cggcacagag 550 cacgcctacc ggcccggccg tagggtgt:gt gctgtccggg ctcacgggga 600 ccctgtctcc gagtcgttcg tgcagcgtgt gtaccagcco ttcctcacca 650 cctgcgacgg gcaccgggcc tgcagca~~ct accgaaccat ctataggacc 700 gcctaccgcc gcagcc-ctgg gctggcc:~ct gccaggcctc: gctacgcgtg 750 ctgccccggc tggaacagga cc:agcgggct tcctggggcc: tgtggagcag 800 caatatgcca gccgccatgc cggaacggag ggagctgtgt ccagcctggc 850 3 <! 5 cgctgccgct gccctgcagg atggcggggt gacacttgcc agtcagatgt 900 ggatgaatgc agtgctacga ggggcggct g tccccagcgc t:gcat.caac:a 950 ccgccggcag ttactggtgc cagtgttggg aggggca<:ag cctgtctgca 1000 gacggtacac t.ctgtgtgcc caagggagc.g c.cc:cccaggg t~ggcccccaa 1050 cccgacagga gtggacac7tg caatgaagga agaagtgcag aggctgcagt 1100 ccagggtgga cctgctggag gagaagctc:c agctggtgct ggccccactg 1150 cacagcctgg cctcgcalgc actggagc<lt gggct~~ccgg accccggcag 1200 cctcctggtg cactccttcc agcagctcgg ccgcatcgac tccctgagcg 1250 agcagatttc cttcctggag gagcagctgg ggtcctgctc ctgcaagaaa 1300 gactcgtgac tgcccagcgc tc<:acgct:~g actgagcccc tcacgccgcc 1350 ctgcagcccc catgcccctg cccaacatgc tgggggtcca gaagccacct 1900 cggggtgact gagcggaagg ccaggcaggg c:cttcctcct cttcctcc:tc 1450 cccttcctcg ggaggctccc cagaccctgg catgggatgg gctgggat_ct 1500 tctctgtgaa tccaccc:ctg gctaccccca ccctggctac cccaacggca 1550 tcccaaggcc aggtggaccc tcagctgagg gaaggtacga gctccctg ct 1600 ggagcctggg acccatUgca caggccaggc agccc:ggagg ctgggtgggg 1650 cctcagtggg ggctgctgcc tga cccc<;ag cacaataaaa atgaaacgtg 1700 <210> 50E~
<~?11> 273 <21.2> PRT
<213> Eiomo Sapiens <400> 508 Met Arg G.ly Ser Gln Glu Val LF~u Leu Met Trp Leu Leu Val Leu i 5 J0 75 Ala Val Giy Gly Tnr Glu His ALa Tyr Arg Pro Gly Arg Arg Val Cys Ala Val Arg Ala His Gly Asp Pro Val Ser Glu Ser Phe Val Gln Arg Val Tyr Gln Pro Phe Leu Thr Thr Cys Asp Gly His Arg Ala Cys Ser Thr 7yr Arg Thr Ile Tyr Arg Thr Ala Tyr Arg Arg Ser Pro Gly Leu 1,1a Pro Ala F,rg Pro F,rg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser Gly Leu Pro Gly Ala Cys Gly Ala Ala 95 7.00 105 Iie Cys Gln Pro Pro Cys Arg Asn Gly Gly Ser Cys Val Gln Pro IC :.15 120 3 ~~ 6 Gly Arg Cys Arg Cy« Pro Aia Gly Trp Arg Gly Asp Thr Cys Gln 12'- 130 135 Ser Asp Val Asp G11:: Cys Ser Ale; Arg Arg Gly Gl.y Cys Pro Gln 19(: 1.4;> 150 Arg Cys Ile Asn Th= F.la G 1y Ser Tyr Trh C:ys Gln C:ys 'rrp Glu 15~, 160 165 Gly His Ser Leu Se_ Ala Asp G1~:; Thr Leu Cys 'Jal Pro Lys Gly 17-~ 175 180 Gly Pro Prc: Arg 'Jai Ala Pro Asn P'ro Thr Gly Val Asp 5er Ala Met Lys Glu Glu Vai Gln Arg Leu Gln Ser Arg Val Asp Leu Leu Glu Glu Lys Leu Gln Leu Val Le,~ Ala Pro Leu His Ser Leu Ala Ser Gln Ala Leu Glu His Gly Leu Pro Asp Pro C~ly Ser Leu Leu Val His Ser Phe Gln Gin lieu Gly Arg Ile Asp Ser Leu Ser Glu 2~!5 250 255 Gln Ile Ser Pi-ie Leu Glu C.;lu Gln Leu Gly Ser Cys Ser Cys Lys 2F.0 265 270 Lys Asp Ser <210> 509 <211> 1538 <2.12:> DNA
<213> Homo sapiens <400> 509 cccacgcgtc cgaagctggc cctgcacggc tgcaagqgag gctcctgtgg 50 acaggccagg caggtg:~gcc tcaggagqtg cctccaggcg gccagtgggc 100 ctgaggcccc agcaagggct aaggtccatc tccagtccca ggacacagca 150 gcggccacca tggccacgcc tgggctccag cagcatcagc agcccccagg 200 accggggagg cacaggtggc ccccacc.scc cggaggagca gctcctgccc 250 ctgtccgggg gatgactgat tctcctc~~gc c.aggccaccc: agaggagaag 300 gccaccccgc ctggaggcac aggccatgag gggctctcag gaggtgctgc 350 tgatgtggct tctggtgttg gcagtgggcg gcac:agagca cgcctaccgg 400 cccggccgta gggtgtgtgc tgtccgggct cacggggacc ctgtctccga 450 gtcgttcgtg cagcgtgtgt a~,cagccctt cctc;accacc tgcgacgggc 500 accgggcctg cagcac:ctac cgaaccatct ataggaccgc ctaccgccgc 550 agccctgggc tggccc:ctgc caggcctcgc tacgcgtgct gccccggctg 600 gaagaggacc agcgggcttc ctggggcctg tggagcagca atatgccaqc 650 cgccatgccg gaacggaggg agctgtgtcc agcctcgccg ctgccgctgc 700 cctgcaggat ggcggggtga cacttgccag tc:agatgtgg atgaatgcag 750 tgctaggagg ggcggcacxtc cccag~~gctg cgtcaacacc gccggcagtt 80G
actggtgcca gtgttgggag ggg:~acagoc tgtctc;caga cggtacactc 850 tgtgtgccca agggaggcrcc ccccagggtg gcccccaacc cgacaggagt 900 ggacagtgca atgaaggaag aagtgcag~_g gctgcagtcc agggtqgacc 950 tgctggagga gaagctg~:ag ctggtgctc;g cccca~~tgca cagcctggcc 1000 tcgcaggcac tggagcatgg gctcccgg<~c cccgg.~agcc tcctggtgca 1050 ctccttccag cagctcggcc gcatcgac'=c cctgagcgag cagatttcct 1100 tcctggagga gcagctgggg tcctcctc~:t gc:aagaaaga ctcgtgactg 1150 cccagcgccc caggctggac tgagcccc~c acgccgccct gcagccccca 1200 tgcccctgcc caacatgctg ggggtccaga ag ccacctcg gggtgactga 1250 gcggaaggcc aggcagggcc ttcctcct~~t tcctcctccc cttcctcggg 1300 aggctcccca gaccctcgca tgggatggg c tgggatcttc tctgtgaatc 1350 cacccctggc tacccccacc ctggctac:cc caacggcatc ccaaggc<;ag 1400 gtgggccctc agctgaggga aggtacgagc: tccct.gctgg agccagggac 1450 ccatggcaca ggccagqcag ccoggagc~ct gggtc~gggcc t.cagtggggg 1500 ctgctgcctg acccccagca caataaaaat gaaacgtg 1538 <210> 510 <~11> 273 <212> PRT
<213> Hcmo sapiens <400> 510 Met Arg Gly Ser GLn Glu Val Le a Leu Met Trp Leu Leu Val Leu 1 5 :LO 15 Ala Val Gly Gly Tnr Glu His A:.a Tyr Arg Pro Gly Arg Arg Val ?0 25 30 Cys Ala Val Arg Ala His Gly A>p Pro Val Ser Glu Ser Phe Val Gln Arg Val Tyr Gln Pro Phe h~~u Thr Thr C:ys Asp Gly His Arg Ala Cys Ser Thr 'Tyr Arg Thr Ile Tyr A.rg Thr Ala Tyr Arg Arg Ser Pro Gly Leu Ala Pro Ala Arg Pro F,rg Tyr Ala Cys Cys Pro 3 ~18 Gly Trp Lys Arg Thr Ser Gly Leu Pro Gly Ala Cys Gly F.la Ala Ile Cys Gln Prc Frc: Cys Arg Asn Gly Gly Ser Cys Val Gln Pro Gly Arg Cys Arg C.:y~ Pro Ala Gly Trp Arg Gly Asp Thr c'ys Gln 12~. 13G 135 Ser Asp Val Asp Gli.~ Cys Ser A1a Arg Arch Gly Gly Cys Pre Gln 14(~ 14~; 150 Arg Cys Val Asn 'lh:r Ala Gly Ser Tyr Trp Cys (~ln Cys Trp Glu 15~~ 160 165 Gly His Ser Leu Sev Ala Asp G1~, Thr Leu Cys 'Jal fro Lys Gly 17!180 1. 7 0 Gly Pro Pro Arg Va1 Ala Pro Asm Pro Thr Gly Val Asp Ser Ala Met Lys Glu Glu Va1 Gln Arg Leu Gin Ser Arg Val Asp Leu Leu Glu G1u Lys Leu Gln Leu Val Leu Al.a Pro Leu His Ser Leu Ala Ser Gln A1<i Leu Glu His G:ly Leu Prc Asp Pro Gly Ser Leu Leu Val His Ser Phe Gln Gln L~eu Gl_v Arg Ile Asp Ser Leu Ser Glu Gln I1e Ser Phe Leu Gl.u (;1u Gln Leu Gly Ser Cys Ser Cys Lys 2(0 2H5 270 Lys Asp Ser <210:~ 511 <211> 27.
<212> DNA
<213> Artificial <220>
<221> Artificial Sc-~quence <222> 1-21 <2'23> Artificial Sequence <900> 51?
tggagcagca atatgc;~agc c 21 <210> 512 <211> 22 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence=
<222> 1-22 <223> Artificial Sequence <900> 512 ttttccacr_c ctgtcgggt.t gg <'2 ~:210> 513 <211> 46 <2 12> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> l.-96 <223> Artificial Sequence <900> 513 ggtgacactt gccagtcaga tgtggatgaa tgcagtgcta ggaggg 96 <210> 519 <211> 2690 <212> DNA
<213> Homo Sapiens <220>
<221> unsure <222> 2039-2065 <223> unknown base <40C> 514 ggttgccaca gctggtttag ggccccgacc actggggccc cttgtcagga 50 ggagacagcc tcc:cggcccg gggaggacaa gtcgctgcca cctttggctg 100 ccgacgtgat tccctgc;gac ggtc~~gtttc ctgccgtcag ctgccggccg 150 agttgggtct ccgtgt~,.tca ggccggctcc cccti:cctgg tctcccttct 200 cccgctgggc cggttta~tcg ggaggagatt gtctt ccagg gctagcaati_ 250 ggacttttga tgatgtttga cccagcggca ggaavagcag gcaacgtgat 30C
ttcaaagctg ggctcagcct ct-gtttcttc tctcgtgtaa tcgcaaaacc 350 cattttggag caggaatt<:c aatcatgtct gtgatggt.gg tgagaaagaa 400 ggtgacacgg aaatgggaga aactccc,~gg caggaacacc ttttgctgtg 450 atggccgcgt catgat:ggcc cggcaaaagg gcattttcta cctgaccctt 500 ttcctcatcc tggggacatg tacactc=tc ttcgcctt:tg agtgccgcta 550 cctgqctgtt cagctatctc ctgccatccc tgtatttgct gccatgctct 600 tccttttctc catggctaca ct gt:tgagga ccagcttcag tgaccct:gga 650 gtgattcctc gggcg<:tacc ac~atgaagca gctttcatag aaatggagat 700 agaagctacc aatggtgcgg tgccccaggg ccaqcgacca ccgc~~tcgta 750 tcaagaattt ccagataaac aaccagattg tga~cac:tgaa atactgttac 800 acatgcaaga tcttcc:ggcc tcc~ccg<~gcc tcc<:attgca gcatctgtga 850 caactgtgtg gagcgcvtt.cg accatcactg cccctgggtg gggaattgtg 900 ttggaaagag gaactaccgc tacttci_acc tctt:catcct ttctctctcc 950 ctcctcacaa tctatgtc:tt cgccttcaac atcgtcaatg tggccctcaa 7.000 atctttgaaa at:tggctt ct tggagacatt gaaagaaact c:ctggaact.g 1050 ttctagaagt cctcatt'gc ttctttacac tctggtccgt c:gtgggactg 1100 actggatttc atactttc:ct cgtggctcic aaccagacaa coaatgaaga 1150 catcaaagga tcatgga:ag ggaagaatc:g cgtccagaat ccctacagcc 1200 atggcaatat tgtgaagaac tgctgtga:ug i_gctgt:.gtgg ccccttgccc 1250 cccagtgtgc tggatcgaag gggtattt",=g cc:actggagg aaagtggaag 1300 tcgacctccc agtactcaag agaccagt<~g cagcctcttg ccacagagcc 1350 cagcccccac agaacacctg aac:tc:aaa~:g agatgccgga ggacagcagc 1900 actcccgaag agatgccacc tccagagc~:;c ccagagccac cacaggaggc 1450 agctgaagct gagaagtagc ctatcaat~~g aagagacttt tgtttgtgtt 1500 taattagggc tatgagagat ttc:ag gtgag aagttaaac:c tgagacagag 2550 agcaagtaag ctgtc:ccttt t::a<ictgtttt tctttggtct ttagtcaccc 1600 agttgcacac tggcattttc ttg ctgcaag cttttttaaa tttctgaa ct 1650 caaggcagtg gcagaacaatg tcagtcac~ct: ctgataactg gaaaaatggg 1700 tctcttgggc c.ctggc<.:ctg gttctccatg gcctcagcca cagggtcccc 1750 ttggaccccc tctcttc:cct ccagatcc::c:a gccctcctgc ttggggtcac 1800 tggtctcatt ctggggcaaa aagttttt.ga gactc~gctca aatcctccca 1850 agctgctgca cgtgctgagt ccagaggc:ag tcac,~gagac ctctggccag 1900 gggatcctaa ctgggt~ctt ggggtctt:ca ggactgaaga ggagggagag 1950 tggggtcaga agattctcct ggccacc<~ag tgccagcatt gcccacaaat 2000 ccttttagga at.gggacagg taccttc~:~ac ttgttgtann nnnnnnnnnn 2050 nnnnnnr.nnn nr:nnnttgtt. tttccttttg actcctgctc ccattaggag 2100 caggaatggc agtaataaaa gtctgcactt tggtcatttc ttttcctcag 2150 aggaagcccg agtgctcact taaacactat cccctcagac tccctgtgtg 2200 aggc:ctgcag aggccctgaa tgcacaaatg ggaaaccaag gcacagagag 2250 gct.ctcctct cctctcctct cccc:cgatgt accca caaaa aaaaaaaaat 2300 gctaaccagt tctt.ccatta agcctcggct gagt:gaggga aagcccagca 2350 ctgctgccct ctcgggtaac tcawcctaag gcct:cggccc acctctggct 2400 atggtaacca cactgggggc ttcctcc:aag ccccgctctt ccagcacttc 2450 caccggcaga gtccc<igagc cacttcaccc tgggggtggg ctgtggcccc 2500 cagtcagctc tgctcaggac ctgctctatt tcagggaaga agatttatgt. 2550 attatatgtg gctatatttc ct.aqagcacc tgt.gttttcc tctttctaag 2600 ccagggtcct gtctggatga cttatgcggt gggggagtgt aaaccggaac 2650 ttttcatcta tttgaagc;cg attaaactc;t gtctaatgca 2690 <210> 515 <2'11> 369 <2>1i_'> PRT
<213:> Homo sapiens <400> 515 Met Ser Val Met Val Val P.rg Ly:, Lys Val Thr Arg Lys Trp Gl.u Lys Leu Pro Gl.y Ar:l Asn Thr Phe- Cys Cys Asp Gly Arg Val Met 2.'> 3G
Met Ala Arg Gln Lys Gly Ile Phi: Tyr Leu Thr Leu Phe Leu Ile Leu Gly Thr Cys Thr Leu F'hE: Phe Al.a Phe Glu Cys Arg Tyr Leu Ala Val Gln Leu Ser Pr.e Ala Ile Pro Val Phe Ala Ala Met Leu Phe Leu Phe Ser Met Ala _'hr Leu Leu Arg Thr Ser Phe Ser Asp E'; 0 ~ 5 9 0 Pro Gly Vai Ile Pro Arg Ala Le~u Pro Asp Glu Ala Ala Phe Ile fa5 100 105 Glu Met Glu Ile G~.u Ala Thr Asn Gly Ala Val Pro Gln Gly Gln 1 i 0 1. 5 120 Arg Pro Pro Pro Arg Ile Lys Ann Phe G.ln Ile Asn Asn Gln Ile 1:'S 130 135 Val Lys Leu Lys Tyr Cys 'I'yr Thr C:ys Lys Ile Phe Arg Pro Pro 1~0 145 150 Arg Ala Ser His Cys Ser Ile Cys Asp Asn Cys 'Jal Glu Arg Phe Asp His His Cys Fro Trp Val Gly Asn Cys Val Gly Lys Arg Asn Tyr Arg Tyr Phe Tyr Leu Phe I.Le Leu Ser Leu Ser Leu Leu Thr Ile Tyr Val Phe F.la Phe Asn Ile Val Tyr Val Ala Leu Lys Ser Leu Lys I.le Gly Phe Leu Glu Thr Leu hys Glu Thr Pro Gly Thr a15 220 225 Val Leu Glu Val I,eu Ile Cys Phe Phe Thr Leu Trp Ser Val Val a 30 a:35 240 Gl.y Leu Thr Gly Phe His T:nr Phe Leu Val Ala Leu Asn Gln Thr 3 -'':~ 2 Tl:r Asn G.lu Asp Ile Lys Gly Ser Trp Thr Gly Lys Asn Arg Val 26C: 265 270 Gln Asn Fro Tyr Ser His Gly Asn Ile Val Lys Asn Cys C'ys Glu 27': 280 285 Val Leu Cys Gly Fr< Leu Pro Pro Ser VaI Leu Asp Arg Arg Gly i:9C: 295 300 Tle Leu Pro Leu C;lt. Glu S<~r Gly Ser Arq Pro Pro Ser ':'hr Gln 30'. 310 315 Glu Thr Ser Ser Ser Leu Leu Prc. GIn Ser Pro AIa Pro Thr G1u 32t,) 32_'330 His Leu Asn Ser Asr: Glu Met Prc~ Gl.u Asp Ser :3er Thr Pro Glu 33'~ 390 345 Glu Met Pro Pro Pr:> Glu Pro Prco Glu Pro Pro Gln Glu Ala Ala 350 35~ 360 Glu Ala Glu Lys <210> 516 <211> 255 <212> DNA
<213> Homo sapiens <220~
<221> unsure <222> 36, 38, 88, 718, 13'., 19 ~, 213, 222 <'223> unknown base <400> 51b aaaaccctgt attttttaca atgcaaatag acaatnancc tggaggtcat 50 tgaattaggt attatac;(gga tggtggggtt gatttatntt cctggaggct 100 tttggctttg gactctcwct ttctccc~aca gagcncttcg accatcac.tg 150 cccctgggtg gggaattgtg ttggaaa<aag gaact:accgc tanttctacc 200 tcttcatcct ttntct~.acc cncctca~:aa tctatgtctt cgccttcaac 250 atcgt 255 <210> 517 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-29 <223> Artificial Sequence <400> 517 caacgtgatt tcaaagctgg gctc 24 <210> 518 <211> 20 x212%~ DNA
<213> Artificial '~2GO%~
<2~1> Artificial Se<luence <222> 1-20 <223> Artifi.ci.al Sequence <400> 518 gcctcgtatc aagaatt'cc 20 <210> 5i9 <211> 18 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-78 <223> Art:ifici.al Sequence <400> 519 agtggaagtc gacctccc 18 <210> 520 <:211> 24 <:212> DNA
<:213=> Artificial <220>
<::221> Artificial Sequence <222:> 1-29 <223> Artificial Sequence <400> 520 ctcacctgaa atctctc:ata gccc 29 '2i0> 521 <'211> 50 <212> DNA
<213> Artificial <220>
<227> Artificial Sequence <222> 1-50 <223> Artificial SequencF
<400> 521 cgcaaaaccc attttgggag coggaat:cc aatcatgt:ct gtgatggtgg 50 <210> 522 <211> 1679 <212> DNA
<213> Homo Sapiens <900> 522 gttgtgtcct tcagcaaaac aqtggattta aatcaccttg cacaagcttg 50 agagcaacac aatct~:tcag gaaaga<~aga aag~iaaaaaa ccgaac~~tga 100 caaaaaagaa gaaaaagaag aaga aaaaaa atcatgaaaa ccatccagcc 150 aaaaatgcac aatt:ctatct cttgggcaat cttcacgggg caggctgcr_c 200 tgtgtctctt ccaaggaatg cccgtgcgca gcggagatgc caccttccc;c 250 aaagctatgg acaacgtc;ac ggtccggc~;g ggggacaagcg ccaccctcag 300 gtgcactatt gacaacccagg tca;;ccggct ggcctggcta aaccgcag;:a 350 ccatcctcta tgctgggaat gacaagtg<at gcctggatcc tcgcgtggtc 400 cttctgagca acacccaaac- gcagtacayc atcgagatcc agaacgtgga 450 tgtgtatgac gagggcc.-tt acacctgctc ggtgcagaca gacaaccacc 500 caaagacctc tagggtc:~ac ctcattgtc:3c aagtatctcc caaaattgta 550 gagatttctt cagatat..tc cattaatgaa gggaacaata ttagcctcac 600 ctgcatagca actggtagac cagagcct,3c ggttacttgg agacacatct 650 ctcccaaagc ggttggcttt gtc~agtga,sg acgaatactt ggaaattcag 700 ggcatcaccc gggagcagtc aggggactac gagtgcagtg cctccaatga 750 cgtggccgcg cccgtggtac ggagagtaaa ggtcaccgtg aactatc<:ac 800 catacatttc agaagcraag ggtacagqtg tcccc:gtggg acaaaagggg 850 acactgcagt gtgaagc:ctc: agcagtcccc tcagc:agaat tccagtggta 900 caaggatgac aaaagactga tt,:3aaggaaa gaaaggggtg aaagtggaaa 950 acagaccttt cctctca-~aaa ctcatcttct tcaatgtctc t.gaacatgac 1000 tatgggaact acacttqcgt ggcctcc~;ac aagci_gggcc acaccaatgc 1050 cagcatcatg ctattt~~gtc caggcgcc:gt cagcgaggtg agcaacggca 1100 cgtcgaggag ggcaggc~tgc gtctggctgc tgcctcttct ggtcttgcac 1150 ctgcttctca aatttt:~atg tgagtgc::ac: ttccccaccc gggaaaggct 1200 gccgccacca ccaccaccaa cacaacagca atggcaacac cgacagcaac 1250 caatcagata tatacaaatg aaattag,aag aaacacapcc tcatgggaca 1360 gaaatttgag ggaggggaac aaagaat:~ct ttggggggaa aagagtttta 1350 aaaaagaaat tgaaaattgc: cttgcagata tttaggtaca atggagtttt 1400 cttttcccaa acgggoagaa cacagca~ae ccggct:tgga cccactgcaa 1450 gctgcatcgt gcaacctctt tg gtgcc:agt gtgqgcaagg gctcagc:ctc 1500 tctgcccaca gagtgc:cccc ac,gtggaaca ttct.ggagct ggccate:cca 1550 aattcaatca gtccaLagag ac:gaacagaa tgac~accttc cggcccaagc 1606 gtggcgctgc gggcar:tttg gtag actgtg cca<:cacggc gt.gtgttgtg 1650 aaacgtgaaa taaaaagagc aaaaaauaa 1679 <210> 523 <211> 349 <21.2> PRT
<21.3> Homo Sapiens <4C0> 523 Met Lys Thr Ile C~lr~ Pro I,ys Met His Asn Ser Il.e Ser 'I'rp Ala i ' 10 15 Ile Phe Thr Gly Leu Ala Ala Lea Cys Leu Phe Gln Gly 'Jal Prc 2ty 2'~ 30 Val Arg Ser Gly Asp Ala Thr Phe Fro Lys Ala Met Asp Asn Val 3 i 90 95 Thr Val Arg Gln Gly Glu Ser Al,3 Thr Leu Arg ~.ys 'I'hr Iie Asp 50 5'. 60 Asn Arg Val Thr Arg Val Ala Trt~ Leu Asn Arg Ser Thr Ile Leu Tyr Ala Gly Asn Asp Lys Trp Cy:~ Leu Asp Pro Arg Val Val Leu Leu Ser Asn Thr Gln Thr Gln Tyr Ser Ile Glu Iie Gln Asn Val ~5 100 105 Asp Val Tyr Asp Glu Gly Fero Tyr Thr Cys Ser Val Gln Thr Asp Asn His Pro Lys TYr Ser Arg Val His Leu Ile Val Gln Val Ser 125 1'0 135 Fro Lys Ile Val G-a Ile ;e:r Se:r Asp Il.e Ser Ile Asn Gl.u Gly 1~i0 145 150 Asn Asn Ile Ser LE'u Thr Cys I2.e Al.a Thr Gly Arg Fro Glu Pro 1p5 1E;0 165 Thr Val Thr Trp A.rg His I:le S<~r Pro Lys Ala Val Gly Phe Val 1 %0 1'75 180 Ser Glu Asp Glu Tyr Leu Glu Ile Gln Gly Ile Thr Arg Giu Gln Ser Gly Asp Tyr Glu Cys Ser A_a Ser Asn Asp Vai Ala Ala Fro Val Val Arg Arg Val Lys Val Thr val Asn 'I'yr Pro Prc, Tyr Ile Ser Glu Ala Lys Gly Thr Gly Val. Pro Val Gly Gln Lys Gly Thr Leu Gln Cys Glu Ala Ser Aia Val t?ro Ser Ala Glu Fhe Gln Trp a45 250 255 Tyr Lys Asp Asp lays Arg Leu Lle Glu C~ly Lys Lys Gly Val Lys a'60 a:6'_i 270 Val Glu Asn Arg Hrc Phe Leu :ver Lys Leu Il<_> Phe Phe Asn Val Ser Glu His Asp ":'yr Gly Asn 'Cyr Thr (:ys Val Ala Ser Asn Lys I~eu Gly His Thr Asr~ Ala Ser Ile Met Leu Phe Gly Fro Gly Ala 30' 31C 315 Val Ser Glu Val :~ex Asn Gl.y Thl Ser Arq Arg Ala Gly Cys Val 32( 325 330 Trp Leu Leu Pro Leu Leu Val Lei: His Leu Leu Leu hys Phe 33'; 390 <210> 529 <211> 503 <212> DNA
<213> Homo Sapiens <400> 524 gaaaaaaaat catgaaaacc atccagccaa aaatgcacaa ttctatctct 50 tgggcaatct tcacggg:4ct ggctgctc~:g tgtctcttcc aaggagtgcc 100 cgtgcgcagc ggagatg:oca ccttcccc~ja agctatggac aacgtgac:gg 150 tccggcaggg ggagagcgcc accctcaggt gcactattga caaccgggtc 200 acccgggtgg cctggctaaa ccgcagcacc atcctctatg ctgggaatga 250 caagtggtgc ctggatc:ctc gcatggtcct tctgagcaac acccaaacgc 300 agtacagcat cgagatccag aacgtggatg tgtatgacga gggcccttac 350 acctgctcgg tgcagacaga caaccaccoa aagacctcta gggtccac:ct 400 cattgtgcaa gtatctccca aaattgtaga gattt.cttca gatatctc~ca 950 ttaatgaagg gaacaa? att age:ctcacct gcatagcaac tggtagac~ca 500 gag 503 <210> 525 <211> 2602 <21Z> DNA
<213> Homo Sapiens <400> 525 atggctggtg acggcggggc cgggcagggg accggggccg cggcccggga 50 gcgggccagc tgccgggagc cctgaatcac cgcctggccc gactccacca 100 tgaacgtcgc gctgcaggag ctgggagutg gcagcaac:gt gggattccag 150 aaggggacaa gacagctgtt. aggca cac:gc acgcagct.gg agctggtctt 200 agcaggtgcc tctctactgc tggctgcact gcttct.gggc: tgccttgtgg 250 ccctaggggt ccagtoccac agagacccat cccacagc:ac ctgccttaca 300 gaggcctgca ttcgactggc tqgaaaaatc ctggagtccc: tggaccgagg 350 ggtgagcccc tgtgaggact tttaccagtt ctcc:tgtggg ggctggattc 400 ggaggaaccc cctgcc:cga t gggcgtt ctc gctggaaca<: ctt:caacagc 450 ctctgggacc aaaaccaggc catactgaag cacctgcttg aaaacaccac 500 cttcaactcc agcagtgaag ctgagcagaa gacacagcgc ttctacctat 550 cttgcctaca ggtggagogc attgaggagc tgggaaccca ctCCactgac:~a 600 gacctcattg agaagatt gg tggt:tggaac attacc~gggc c:ctgggacca 650 ggacaacttt atggaggtgt tgaagg cac;t agcagc~gacc t~acagggcca 700 c~cacattctt caccgtc~:aa atcagtgcrg actct<3agag r_tccaacagc 750 aatgttatcc aggtgga~:ca gtctgggctc tttctgccct ctcgggatta 800 ctacttaaac agaactg;:ca atgagaaacTt gctcactgcc tatctggatt 850 acatggagga actgggg;~tg ctgctggg'=g ggcgg~~ccac ctccacgagg 900 gagcagatgc agcaggty ct= ggagttgga g at.acagctgg ccaacatcac 950 agtgccccag gaccagcggc gcgacgagga gaagatctac cacaagatga 1000 gcatttcgga gctgcaggct ctggcgccct ::catggactg gcttgagttc 1050 ctgtctttct tgctgtc:acc attggagttg agtgactctg agcctgtggt 1100 ggtgtatggg atggattatt t.gc:agcaggt gtcagagctc atcaaccgca 1150 cggaaccaag catcctaaac aattacctga tctggaacct ggtgcaaaag 1200 acaacctcaa gcctggaccg acgcl~ttgag tctgc:acaag agaagc:tgct 1250 ggagaccctc tatggc<cta agaagtcc;tg t.gtgc:cgagg tggc:agacct 1300 acatctccaa cacggatgac: gcccttggct ttgct:ttggg gtcactc~t.c 1350 gtgaaggcca cgtttga-lccg gcr~aagca~aa gaaat tgcag aggggatgat 1400 cagcgaaatc cggaccrtcat ttgaggac:,gc:. c:ctgc3gacag ctggtttgga 1450 tggatgagaa gacccg<;cag gcagccaa gg agaaagcaga tgccatctat 1500 gatatgattg gtttcc:.aga ctttatc::ag gagcccaaag agctggatga 1550 tgtttatgac gggtac3aaa tttctgaaga ttctttcttc caaaacatgt 1600 tgaatttgta caactt~~tct gccaaggt.ta t_ggctgacca gctccgcaag 1650 cctcccagcc gagacc.agtg gagcatga cc ccccagacag tgaatgccta 1700 ctaccttcca actaagaatg agatcgt:at ccccgctggc atcctgcagg 17'>0 cccccttcta tgcccgcaac cacc:ccaa~gg ccctgaactt cggtggr:atc 1800 ggtgtggtca tgggccatga gttgacgcat gcctttgatg accaagggcg 1850 cgagtatgac aaagaaggga ac:ct:gcggcc ca ggtggcaq aatgagtccc 1900 tggcagcctt ccggaa~ccac ac:ggcctgca tggaggaaca gtacaatcaa 1950 taccaggtca atggggagag gcac~aacggc cgcc:agacgc tgggggagaa 2000 cattactgac aacggc~gggv tga,sggctgc ctacaatgct tacaaagcat 2050 ggctgagaaa gcatggggag gagceagcaac tgccagccgt ggggctcacc 2100 aaccaccagc tcttct.tc:gt gggatttgcc caggtcrtggt gctcggtccg 2150 cacaccagag agctctcacg aggggctggt gaccgacccc <:acagccctg 2200 cccgcttccg cgtgctgqgc actct~Ltc<~a actcccgtga cttcctgcgg 2250 cacttcggct gccctgtogg ctcccccat.g aacccagggc agctgtgtga 2300 ggtgtggtag acctggatca ggggagaaat ggccagctgt caccagacct 2350 ggggcagct:c tcctgac<3aa gctgtttgia catgggttgg gaggaagcaa 2900 atgcaagctg ggctgggtct agtccct.c~:c cccca~~aggt gacatgagta 2450 cagaccctcc tcaatcacca cattgtgc;:~t ctgctttggg ggtgcccctg 2506 cctccagcag agccccc,~cc att:cactg~::g acatctttcc gtgtcaccct 2550 gcctggaaga ggtctgggtg gggaggcc,:~g ttcccatagg aaggagtctg 2600 cc 2602 <210> 526 <211> 736 <212> PRT
<213> Homo Sapiens <900> 525 Met Asn Val Ala LE~u GIn alu Leu Gl.y A7.a Gl.y Ser Asn Val Gly 1 5 7 0 1. 5 Phe GI,n Lys Gly Thr Arg ~:~ln Leu heu G_y Ser Arg Thr Gln Leu :'0 a?5 30 Glu Leu Val Leu Ala Gly Ala Scv,r Lea Le a heu Ala Ala Leu Leu i5 ~10 95 Leu Gly Cys Leu Val Ala L~eu Gy 'Jal Gln Tyr tlis Arg Asp Pro Ser His Ser Thr Cys Leu Thr Giu Ala Cys Lle Arg Val Ala Gly Lys Ile Leu Glu Ser Leu Asp Arg Gly Val Ser Pro Cys Glu Asp Phe Tyr Gln Phe Ser Cys Gly Gly 'I'rp Ile Arg Arg Asn Pro Leu Pro Asp Gly Arg Ser Arg 'rrp Asn Th r Fhe Asn Ser Leu Trp Asp Gln Asn Gln Ala Ile Leu L_vs His Leu heu Glu Asn Thr Thr Phe Asn Ser Ser Ser <;1u Ala Glu Cln Lys Thr Gln Arg Phe Tyr Leu ~9G 145 150 Ser Cys Leu Gln Val Glu Arg ~le Glu Glu Leu Gly Ala Gln Pro 55 ., 60 165 3 !~ 9 Leu Arg Asp Leu 11E Glu Lys Ile Gly Gly Trp Asn Ile 'I'hr Gly Pro Trp Asp Gln AsI- Asn Fhe Met Glu Val Leu Lys Ala Val Ala 18' 190 195 Gly Thr Tyr P.rg Alra Thr Pro Phe Phe Thr Val Tyr I:le Ser Ala 20(' 205 210 Asp Ser Lys Ser Ser Asn Ser Asn Val Ile Gln 'Jal Asp Gln Ser 21', 220 225 Giy Leu Phe Leu Pr~~ Ser Arg Asx> Tyr Ty.r Leu Asn Arg Thr Al.a 23:) 23'~ 240 Asn Glu Lys Val Leu Thr Ala Tyr L,eu Asp Tyr Met Glu Glu Leu Gly Met Leu Leu Gly Gly Ara_ Pre Thr Ser Thr Arg Glu Gln Met Gln Gln Val Leu Glu Leu C~lu Ile G.l_n Leu Ala Asn Ile Thr Val Pro Gln Asp Gln Arg Arg Asp Glw Glu Lys Ile Tyr Hl.s Lys Met Ser Ile Ser Glu Leu Gln Ala Leu Ala Pro Ser Met Asp Trp Leu 3f~5 310 315 Glu Phe Leu Ser PY:e Leu Leu Ser Pro Leu Glu Leu Ser Asp Ser 3r'0 325 330 Glu Pro Val Val Val Tyr Gly Met Asp Tyr Leu Gln Gln Val Ser 3a5 340 345 Glu Leu Ile Asn Arg Thr ~=lu P:o Ser I:Le Leu Asn Asn Tyr Leu Ile Trp Asn Leu Val Gln Lys TPnr Thr Ser Ser Leu Asp Arg Arg 3~5 3'70 375 Phe Glu Ser Ala Gln Glu Lys Leu L,eu Glu Thr Leu Tyr Gly Thr Lys Lys Ser C.'ys Val Pro Arg Trp G In Thr Cys Ile Sex Asn Thr Asp Asp Ala Leu GIy Phe Ala Leu Gly Ser Leu Phe Val Lys Ala Thr Phe Asp Arg C--In Ser Lys Glu Tle Ala Gla Gly Met. Ile Ser Glu Ile Arg Thr F;la Phe G:Lu C;lu Ala heu Gly Gln Leu Val Trp Met Asp Glu Lys Thr Arg Gln Ala Ala hys Glu Lys Ala Asp Ala Ile Tyr Asp Met ;:1e Gly P:~e I-'ro Asp I?he Ile Leu Gla Pro Lys 470 <175 480 Glu Leu Asp Asp Val Tyr Asp Gly Tyr Glu Ile Ser Glu Asp Ser 48~- 99C 495 Phe Fhe Gln Asn Met Leu Asn Let: Tyr Asn Phe Ser Ala L~ys Val 50C 50't 510 Met Ala Asp C-In Lei; Arg Lys Pr;Pro Ser Arg Asp Gln 'I'rp Ser 51-'520 525 Met Thr Pro Gln Th; Val Asn Al~a Tyr Tyr heu Pro Thr i.,ys Asn 53~~ 535 540 Glu Ile Val Phe Pr~:~ Ala Gl.y I1:' Leu Glo Ala Pro Phe Tyr Ala 54=> 55~~ 555 Arg Asn His Pro Lys Ala Leu P.su Phe Gly Gly Ile Gly Val Val Met Gly His G1_u Leu Thr His Al,~ Phe Asp Asp Gln Gly Arg Glu Tyr Asp Lys Glu Gly Asn I,eu Arg Pre Trp Trp Gln Asn Glu Ser Leu Ala Ala Phe Arg Asn His Thr Ala Cys Met Glu Giu Gln Tyr Asn Gln Tyr Gln V~~1 Asn C,lv Glu Arg Leu Asn Gly Arg Gln Thr 6a0 ~ 625 630 Leu Gly Glu Asn Ile Thr Asp Asn Gly Gly Leu Lys Ala Ala Tyr 6: 5 640 645 Asn Ala Tyr Lys A~a Trp Leu Arg Lys His Gly Gl.u Glu Gln Gln 6'>0 655 660 Leu Pro Ala Val G.~y Leu 'Chr Ann His Gln Leu Phe Phe Val Gly 6~;5 b'70 675 Phe Ala Gln Val Tip Cys Ser V~~1 Arg Thr Pro Glu Ser Ser His 630 6~=>5 690 Glu Gly Leu Val T:~r Asp Pro His Ser Pro Ala Arg Phe Arg Val Leu Gly Thr Leu Ser Asn Ser Arg Asp Phe Leu Arg His Phe Gly Cys Pro Val Gly Ser Pro Met A:~n Pro Gly Gln Leu Cys Glu Val.

Trp <210> 527 <211> 4308 <212> DNA
<213> Homo sapien:;
<220>
<221> unsure <222> 1978, 3978, 4057-9058, 4070 3iil ~223> unknown base <400> 527 gcccggccct ccgccctc:cg cactcccgr~ tccctccctc c:gcccgctcc 50 cgcgccctcc tccctccctc ctccccagct gtcccgttcg <:gtcatgccg 100 agcctcccgg ccccgcccrgc cccgc~gctg ctcctc:gggc tgctgctgct 150 cggctcccgg ccggcccgcg gcgc:cggcc:c agagcccccc gtgctgccca 200 tccgttctga gaaggagc:cg ctgcccgttc ggggagcggc aggtaggtgg 250 gcgcccgggg gaggcgcyagg cggggagtcg ggctcg gggc gagtcagcgc 300 cagcccggag ggggcgc;:agg gcgcaggtclg ctcggcgcgg cgggcggccc 350 ggagggtggg cgggggc,~ga agggcgcggt gcctgggacc cgggacccgc 400 gggcagcccc cggggcggca cacggcgccla gctgggcagc ggcctccagc 950 caagcccgtc cccgcaggct gcaccttcc~g cgggaaggtc tatgccttgg 500 acgagacgtg gcacccggac ct.aggggac~c cattcggggt gatgcgctgc 550 gtgctgtgcg cctgcgaggc gccagtggggt caccgtacca ggggccctgg 600 cagggtcagc tgcaagaaca tcaaaccaga gtgcccaacc ccggcctgtg 650 ggcagccgcg ccagctaccg ggac<ict~ct, g<.:cagacctg cccccaggac 700 ttcgtggcgc tgctgac:agg gcc:gaggt cg caggcggtgg cacgagc<;cg 750 agtctcgctg ctgcgcicta gcca ccgctt ct:.ctatctcc tacaggcggc 800 tggaccgccc taccagciatc cgc;ttctcag actcc:aatgg cagtgtcct.g 850 tttgagcacc ctgcage ccc cacccaac:aat. ggcctggtct gtggggtgtg 900 gcgggcagtg cctcgg~:tgt ctctgcgact. ccttagggca gaacagctgc 950 atgtggcact tgtgac:~ctc actcacc~at caggggaggt ca gggggcct 1000 ctcatccggc accggg:_cct gtccccaqag acctt.cagtg ccatcctgac 1050 tctagaaggc ccccac~agc agggcgt<~gg gggcatcacc ctgctcactc 1100 tcagtgacac agaggactcc ttgcattt:tt tgctgctctt ccgaggcctt 1150 gcaggactaa cccaggttcc cttcagg,~tc cagattctac accaggggca 1200 gctactgcga gaacttcagg ccaatgtctc agcccaggaa ccaggctttg 1250 ctgaggtgct gcccaacctg acagtccagg agatggactg gctggtgctg 1300 ggggagctgc agatggccct ggagtgg:3ca ggcaggccag ggctgcgcat 1350 cagtggacac attgctgcca ggaagagctg cgac:gtcctg caaagtgtcc 1900 tttgtggggc taatgccctg at:cccaatcc aaac:gggtgc tgccggctca 1450 gccagcctca ctctgr-tagg aaa~ggc-ncc ctgatcctcc aggtgcaott 1500 3p2 ggt.agggaca accagtgGgg tggtggccat gacactggaa accaagcctc 1550 agcggaggga tcagcccacct gtcc~tgtgoc acatggctgg c:ctatcctcc 1600 c:ctgccccca ggccgtgcagt atctgccct.g ggctggggtg cccgaggggc 1650 tcatatgctg ctgcaga<-;tg agctcttcc:t. gaacgi.gqgc <3ccaaggact 1700 tcccagacgg agagcttcgg gggcaacgtg gctgccctgc c ctactgtgg 1750 ggcatagcgc ccgccctgcc cgtgcccct:a gcaggagccc tggtgctacc 1800 ccctgtgaag agccaagcag cagggcac:;3c ctggctttcc ttggat.accc 1850 actgtcacct gcactatgaa gtgctgctcxg cctgggcttgg tggctcagaa 1900 caaggcactg tcactgcc ca cctc cttg;xg cctcctggaa cgccagggcc 1950 tcggcggctg ctgaagggat tctat.ggctc agaggcccag ggtgtggtga 2000 aggacctgga gccggaactg ctgcggcacc tggcaaaagg catggcttcc 2050 ctgatgatca ccaccaaggt ag<:cc:cag.ag gcxgagctccg agggcagcct 2100 ctcctcccag gtgcacatag ccaa<:caatg tgaggttggc ggactgcgcc 2150 tggaggcg gc cggggcrgag ggggtgccagg cgctqggggc tccggat<--~ca 2200 gcctct.gctg cgccgcctgt ggtgcctcagt. ctccc:ggccc tagcgcccgc 2250 caaacctggt ggtc<acaggc gg<:cccgaga c:ccc<iac:aca tgcttcttcg 2300 aggggcagca gcgcccc;cac ggggctcg ct. gggcg cccaa ctacgacccg 2350 ctctgctcac tctgca<:ct.g ccagaga~,ga acggtgatct gtgacccggt 2900 ggtgtgccca ccgccc:~gct gc_ccacar:cc ggtgcaggct cccgaccagt 2450 gctgccctgt t;tgccctggc tgctatt~:t=g atggtgaccg gagctggcgg 2500 gcagcgggta cgcggt.~gca ccccgttc:~tg cccccctttg g cttaattaa 2550 gtgtgctgtc tacacctgca aacaggg:~gg cactggagag gtgcactgtg 2600 agaaggtgca gtgtccccgg ctggcct::xtg cccagcctgt gcgtgtc.aac 2650 cccaccgact gctgcaaaca gtgtcca:~gt: gaggcccacc cccagctggg 2700 ggaccccatg caggctgatg ggccccgggg ctgccgtttt gctgggcagt 2750 ggttcccaga gagtcagagc tggcacccct c:agtgccccc: gtttggagag 2800 atgagctgta tcacctgcag atgtggggta agtggggagc agaggct:tgt 2850 gtgaggtggg tactgggagc ctggtctgga gtagggagac: cttcccaggg 2900 aggtccctga agaag<agaa ggt~~actgtg tccc:agtgcc tctgggggac 2950 actcagtgtc tgctct.gtct tgt.accaggc aggggtgcct cactgtgagc 3000 gggatgactg ttcacrgcca c:tgtcctgtg gctcggggaa ggagagtcga 3050 tgctgttccc gctgcacggc ccaccgcrcgg cgt<3agtgag ggagtccagg 3100 gtcagcagct gtgagtggag ggctcacctg cctgtgggac tcctgat.cag 3150 ggaagggagc actr_actgtg tgcaggaaca gtgcagcctg cctcacaagt 3200 gccattccaa tccaccctca cagcaacctg gtggaa.ttgt: tatttatgac 3250 cttttcttta caaatgacaat ttct=gaagct cagagaaatt aagcaacgag 3300 atgaaggtca cccagctcrtg tgcactgacc tgttt<igaaa atactggcct 3350 ttctgggacc aaggcaggga tgctttgccc tgccctctat gcctctctgt 3400 gcctctccac tccctcta cc ctcctcca<,c- attccctccc ttctgtctcc 3950 agcagcccca gagaccagaa ctgatcca<~a gctggagaaa gaagccgaag 3500 gctcttaggg agcagccaga gggccaagt:g accaagagga tggggcct.ga 3550 gctggggaag gggtggcatc gaggacctt.c ttgcattctc ctgtgggaag 3600 cccagtgcct ttgctcctct gtcctgcct:c tactcccacc cccactacct 3650 ctgggaacca cagctccaca agggggagaa gcagctgggc cagaccgagg 3700 tcacagccac tccaagtcct gccctgcc;~c cctcggcctc tgtcct.ggaa 3750 gccccacccc tttcttcctg tacataatgt cactggcttg ttgggatt.tt 3800 taatttatct tcactcagca ccaag ggccc cggacactcc actcctgca g 3850 cccctgagct gagcagagtc attattggag aqttt.tgtat ttattaaaac 3900 attt.cttttt: cagtcat tgg gcatgagc;ti: ggctcattgt ggccaggaac 3950 cagagtgggg cctggtggag aaggggcr:ga gagtaggagg t.gagagagag 4000 gagctctgac acttggggag ctgaaagaga cctggagagg c:agaggatag 4050 cgtggcnntt. ggctgg~:atn cctgggttcc gcagaggggc tggggatggt 4100 tcttgagatg gtctag-jgac tcaagaattt aggga agtag aagcaggatt 9150 ttgactcaag tttagt'.tcc cac:atcgcag gcctg tttgc tgacttcatg 4200 tttgaagttg ctccagagag agaatca<:ag gtgtcaccag cccctctctc 9250 cctccttccc ttcccttccc tttctttcvcc tcccctcccc tcccctcccc 4300 tcccctcc 9308 <210> 528 <211> 1285 <212> DNA
<213> Homo sapien <400> 528 ggccgagcgg gggt.gctgcg cggcggccgt gatggctggt= gacggcgggg 50 ccgggcaggg gaccgc;ggcc g<:ggcccggg agcgggccac~ ctgccgggag 100 ccctgaatca ccgccvggcc cgactcc:aCC atgaacgtcg cgctgcagga 150 3h9 gctgggagct ggcagcaacg tgggattcc<~ gaaggggaca agacagctrt 200 taggctcacg cacgcagctg gagca ggtcr tagcaggtgc ctctctactg 250 ctggctgcac: tgcttctagg ctgc:cttgtg gccctagggg tccagtacca 300 c.agagaccca tcccacacca cctctccttac agaggcctgc attcgagtgg 350 caggaaaaat cctggagtcc ctggaccgag gggtgagccc c:tgtgaggac 400 ttttaccagt tctcctgtgg gggc~tggat t c:ggaggaacc c:cctgcccga 450 t;gggcgt:tct cgctgga~:zca ccttcaacag cctct<~ggac caaaaccagg 500 ccatactgaa gcacctgcat gaaaacacca c cttcaactc cagcagtgaa 550 gctgagcaga agacacagcg cttctacct:a tcttgcctac aggtggagcg b00 cattgaggag ctgggag~;cc agccactg~:cg agacctcatt gagaagattg 650 gtggttggaa cattacg~:lgg ccctgggacc aggac.=actt tatggaggtg 700 ttgaaggcag r_agcagggac ctacagggcc accccattct tcaccgtcta 750 catcagtgcc gactctaaga gttccaac<sg caatgttatc caggtggacc 800 agtctgggct ctttctgccc tc.tcggga-_t aca acttaaa cagaactgcc 850 aatgagaaag taaggaacat cttccgaac~c cccatcccta cccctggctg 900 agctgggctg atccctgttg acttttcc.~t t:tgccaaggg tcagagcagg 950 gaaggtgagc ctatcctgtc acct<3gtgaa caaactgccc ctcctttc,tt 1000 tcttct.tttc ttcct.ccctc cctccctttc ttcccctttt cctt.cctr_cc 1050 ttcctcttat tcttctagta ggtttcatag acacc;tactg t.gtgcc:aggt 1100 ccagtggggg aattcgqaga t,ata~agtttc cgagccattg ccacaggaag 1150 cgttcagtgt cgatgggttc atggacct ag atagc~ctgat aacaaagctc 1200 acaagagggt cctgaggatt caggagac:ac ttatggagcc agcaaagtct 1250 t:cctgaagag attgca~tta agccaggtcc tgtag X285 <210> 529 <211> 1380 <212> DNA
<21.3> Homo sapiens <400> 529 atgcctacta ccttccaact aagaatgaga tcgtcttccc cgctggcatc 50 ctgcaggccc ccttctatgc ccgcaaccac cccaaggccc tgaactt.cgg 100 tggcatcggt gtggtcatgg gccatgagtt. gacgcatgcc: tttgatgacc 150 aagggcgcga gtatgacaaa gaagggaacc tgcggccctg gtggcaqaat 200 gagtccca gg cagccttccg gaaccac:acg gcct.gcatgg aggaacagta 250 caatcaatac caggtcaatg gggagaggct caac:ggccgc: cagacgctgg 300 gggagaacat tgctgacaac ggggggctga aggctgccta c:aatgcttac 350 aaagcatggc tgagaaagca tggggaggag cagcaactgc c:agccgtggg 400 gctcaccaac caccagct ct tctt.cgtgc;g at t.tgc:ccag gtgtggtgc-t. 950 cggtccgcac accagagagc tctcacgac~g ggctggtgac cgacccccac 500 agccctgccc gcttccgc:gt gctgggca< t <:t_ctcc:aact cc:cgt:gactt 550 cctgcg_qcac ttcggctclcc ctgtcggctc ccccatgaac ccagggcagc 600 tgtgtgaggt gtggtagacc: tggatcag~:Ig gagaa,3tggc cagctgtcac: 650 cagacctggg gcagctc=cc: tgacaaag~a gtttgctctt gggttgggag 700 gaagcaaatg caagctgggc tgggtcta~lt ccctcccccc cacaggtgac 750 atgagtacag accctcctca atcac:cacat tgtgcctctg ctttgggggt 800 gcccctgc-ct ccagcagagc ccc-caccatt cactgtgaca tctttccgtg 850 tcaccctgcc tggaagaggt ctgggtgggg aggccagttc ccatagg-<cag 900 gagtctgc.ct cttctgtccc: caggctcact cagccaggcg gccatggggc 950 ctgccgtgcc tgccccactg tgacccacag gcctgggtgg tgtacctcct 1000 ggacttctcc ccaggci.cac tcagtgccca cttaggggtg gactcagctc 1050 tgtctggctc accctcacgg gctaccccvca cctcaccctg tgctccttgt 1100 gccactgctc ccagtgc:tgc tgctgac~wtt c:actgacagc tcctagtgga 1150 agcccaaggg cctctg:~aag cctcctgc:tg ccca~~tgttt c:cctgggctg 1200 agaggggaag tgcatatgtg tagcgggt:ac tggttcctgt g tcttagggc 1250 acaagcctta gcaaatgatt gattctc;:ct. ggacaaagca ggaaagc:aga 1300 tagagcaggg aaaaggaaga ac:agagttta t:.ttttacaga aaagagggtg 1350 ggagggtgtg gtcttggccc ttat:agg,~cc 1380 <210> 530 <211> 39 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence.
<222> 1-39 <223> Artificial :sequence <400> 530 gaagcagtgc agccaclcagt agagaggcac: ctgct.aaga :39 <210> 531 <211> 29 <212> GNA
<213> Artificial.

<220>
<221> Artificial. Sequence <222~~ I-24 <223> Artificial Sequence <400> 531 acgcagctgg aactggt~:at agcy 24 <210> 532 <211> 24 <212> DNA
<21.3> Artificial <22_0>
<221> Artificial Sequence <222> 1-29 <223> Artificial Sequence <400> 532 ggtactggac ccctagggcc acaa 24 <210> 533 <211> 21 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-21 <223> Artificial Sequence.
<400> 533 cctcccagcc gagacc;3gtg g 21 <210> 539 <211> 21 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-21 <223> Artificial ~~equence <400> 534 ggtcctataa gggcca~agac c 21 <210> 535 <211> 99 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-99 <223> Artificial. Sequence <400> 535 gactagttct agatcgcgag cggccgccct tttttttttt tttt 94 <210> 536 <211=> 16 <212> DNA

<'213> Artificial <220>
<221> Artificial Sequence <222> 1-7.6 W'23> Artificial SPrn »n~P
<900> 536 c.ggacgcgtg ggtcga 16 ~''<'10> 537 ~211> 21 <212> DNA
W 13> Artificial <220>
W:21> Artificial Sequence <222=> 1-21 <223> Artificial Sequence <400> 537 c:ggccgtgat gqctggtga:v g 21 <210> 538 <211> 20 <212> DNA
<213> Artificial <220>
<221> Artificial. Sequence <222> 1-20 <223> Artificial. Sequence <400> 538 ggcagactcc ttcctatggca 20 _s68 DE~IANDES OU BREVETS VOLUl~TINEUX
LA PRESENTE PAR'TIE DE CETTE DEVL~NDE OU CE BREVETS
C01'IPREND PLUS D"UN TO1~IE.
C ECI EST LE T01~IE ~ DE~
NOTE: Pour les tomes additionels, veillez contacter 1e Bureau Canadien des Brevets.
JL' MBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION / PATENT CONTAINS MORE
THAN ONE VOLUME.
'THIS IS VOLC,'ME~ OF
NOTE: For additional volumes please contact the Canadian Patent Office.

Claims

WHAT IS CLAIMED IS:

1. Isolated nucleic acid having at least 80% sequence identity to a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence shown in Figure 196 (SEQ ID NO:468).

2. The nucleic acid of Claim 1, wherein said nucleotide sequence comprises the nucleotide sequence shown in Figure 195 (SEQ ID NO:467).

3. The nucleic acid of Claim 1 or Claim 2, wherein said nucleotide sequence comprises the full-length coding sequence from within the sequence shown in Figure 195 (SEQ
ID NO:467).

4. The nucleic acid of Claim 1 which comprises the full-length coding sequence of the DNA deposited under accession number ATCC 209865.

5. Isolated nucleic acid having a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence shown in Figure 196 (SEQ ID NO:468).

6. The nucleic acid of Claim 5, wherein said nucleotide sequence comprises the nucleotide sequence shown in Figure 195 (SEQ ID NO:467).

7. The nucleic acid of Claim 5 or Claim 6, wherein said nucleotide sequence comprises the full-length coding sequence from within the sequence shown in Figure 195 (SEQ
ID NO:467).

8. The nucleic acid of Claim 5 which comprises the full-length coding sequence of the DNA deposited under accession number ATCC 209865.

9. A vector connprising the nucleic acid of any one of claims Claim 1 to 8.

10. The vector of Claim 9 wherein said nucleic acid is operably linked to control sequences recognized by a host cell transformed with the vector.

11. A host cell comprising the vector of Claim 9 or Claim 10.

12 The host cell of Claim 11 wherein said cell is a CHO cell, an E. toll or a yeast cell.

13. A process for producing a polypeptide comprising culturing the host cell of Claim 11 or Claim 12 under conditions suitable for expression of said polypeptide and recovering said polypeptide from the cell culture.

14. Isolated polypeptide comprising a sequence having at least 80% sequence identity to the amino acid sequence shown in Figure 196 (SEQ ID NO:468).

15. Isolated polypeptide comprising a sequence having at least 80% sequence identity to the amino acid sequence encoded by the nucleotide deposited under accession number ATCC
209865.

1 (i. Isolated polypeptide comprising a sequence having the amino acid sequence shown in Figure 196 (SEQ ID NO:468).

17. Isolated polypeptide comprising a sequence having the amino acid sequence encoded by the nucleotide deposited under accession number ATCC 209865.

18. A chimeric molecule comprising a polypeptide according to any one of Claims 14 to 17, fused to a heterologous amino acid sequence.

19. The chimeric molecule of Claim 18 wherein said heterologous amino acid sequence is an epitope tag sequence.

20. The chimeric molecule of Claim 18 wherein said heterologous amino acid sequence is a Fc region of an immunoglobulin.

21. An antibody which specifically binds to a polypeptide according to any one of Claims 14 to 17.

22. The antibody of Claim 21 wherein said antibody is a humanised antibody.

23. The antibody of Claim 21 wherein said antibody is a monoclonal antibody.

24. The antibody of Claim 23 wherein said antibody is a chimeric antibody.

25 A composition comprising an antibody according to any one of Claims 21 to inadmixture with a pharmaceutically acceptable carrier.