CA2421364A1 - Novel polypeptides and nucleic acids encoding the same - Google Patents

Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Description

DE1~IA~TDES OU BREVETS VOLUl~'IINEUX
LA PRESENTE PARTIE DE CETTE DEVLANDE OU CE BREVETS
COVIPREND PLUS D'UN TOME.
CECI EST LE TOME ~ DE
NOTE: Pour les tomes additionels. veillez contacter 1e Bureau Canadien des Brevets.
JUMBO APPLICATIONS / PATENTS
THIS SECTION OF THE APPLICATION i PATENT CONTAINS WORE
THAN ONE VOLUME.
THIS IS VOLUME OF
NOTE: For additional volumes please contact the Canadian Patent Office.

His Phe Leu Ala Leu Asp Al.a Ser Gln His Ser Ser Leu Ser Thr 245 a50 255 Arg Phe G.Ly Thr Val Ala Val Pro Asn 1.1e Leu Leu Phe C;ln Gly 260 a:65 270 Ala Lys P.ro Met. Ala Arg Phe Asn Hi.s fhr Asp Arg Thr Leu Glu 275 ~'80 285 Thr Leu Lys Ile Phe Ile Phe Asn G~~n Thr Gly Ile Glu Ala Lys 290 :?95 300 Lys Asn Vai. Val. Val Th:r Gl,n Ala Asp (~ln Il,e C~ly Fro L~eu Pro Ser Thr Leu Ile L,ys Ser Val Asp Trp Leu Leu Val Phe Ser Leu Phe Phe Leu Ile Ser Phe Il.e Met Tyr Ala Thr I:le Arg Thr Glu Ser Iie Arg Trp Leu Ile Pro Gly Gln Glu Gln (~lu His 'Jal Glu <210> 911 <211> 29 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-29 <223> Artificial Sequence <400> 911 cacagagcca gaagtggcgg aatc 29 <210> 412 <211> 25 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-25 <223> Artificial Seauence <400> 912 ccacatgttc ctgctcttgt cctgg 25 <210> 413 <211> 45 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> I-45 <:223> Artificial Sequence <900> 413 2 6 .:

cggtagtgac tgtactctag tcctgtttta caccccgtgg tgc:cg 45 -:210> 419 <:211> 1166 <:212> DNA
<:.213> Hcmo sapiens <.-400> 419 cccggctccg ctccctctgc cccctcgggg t.cgc:gcgccc acgatgctcc 50 agggccctgg ctcgctgctg ctgctcttc~:~ tcgc:ctcgca ctgctgcctg 100 ggctcggcgc gcgggctctt cctctttggc cagcccgact tctcctacaa 150 gcgcagcaat t.gcaagccca tcccggtcaa cca<~cagctg tgccacggca 200 tcgaatacca gaacatgcgg ctg<vcc:aacc tgct:gggcca cgagaccatg 250 aaggaggtgc tggagcaggc cggc:gcttgg atcc.cgctgg tcatgaagca 300 gtgccacccg gacaccaaga agttcctgtg ctcgctct:tc gcccc:cgtct 350 gcctcgatga cctagacgag accatccaac catgcc:actc qctctgcgtg 400 caggtgaagg accgctgcgc ccc<gt:catg tccgccat.cg gcttcccctg 450 gcccgacatg cttgagtgcg accgtttc<:c ccaggacaac ctacct.ttgca 500 tccccctcgc tagcagcgac cac~:tcctgc cagccaccga ggaagctc~~a 550 aaggtatgtg aagcctgcaa aaataaaaat galgat.gaca <3cgacata;~t: 600 ggaaacgctt tgtaaaaatg attttg cac-t gaaaat.aaaa gtgaaggaga 650 taacctacat caaccgagat acc:~aaato.a t:cctgc~agac caagagcaag 700 accatttaca agctgaacgg tgtgtccg<aa agggacctga agaaatcggt 750 gctgtggct:c aaagacagct tgcagtgcu c ctgtg«ggag at:gaacgaca 800 tcaacgcgcc ctatctggtc atgggacaga aacagggtgg ggagctggtg 850 atcacctcgg tgaagcggtg gcagaagggg cagag,sgagt tcaagcgcat 900 ctcccgcagc atccgcaagc tgcagtgcT:a gtcccggcat cctgatggct 950 ccgacaggcc tgctccagag cacggctgac cat.ttctgct ccgggatctc 1000 agctcccgtt ccccaagcac actcctag:Jt gctccagtct cagcctgggc 1050 agcttccccc tgccttttgc acgtttgcat ccc:cagcatt tcctgagtta 1100 taaggccaca ggagtggata gctgttttca c:ct:aaaggaa aagcccaccc 1150 gaatcttgta gaaatattca aacaaataaa atc:atgaata ttttaa X196 <210> 915 <211> 295 <212> PRT
<213> Homo sapiens <400> 915 Met Leu Gln Gly Pro Gly Ser Leu Leu Leu Leu Phe Leu Ala Ser 26~:

1. 5 10 15 His Cys Cys Leu Gly Ser Al.a Arg Gly heu Phe Leu Phe Gly Gln Fro Asp Phie Ser Tyr Lys Arg Ser Asr~ C'ys Lys Fro Ile Pro Val Asn Leu Gln Leu Cys His Gly Ile Glu Tyr Gir_ Asn Met ~?rg Leu Fro Asn Leu Leu Gly His Glu Thr Met Lys G1u Val Leu C.lu Gln Ala Gly Ala Trp Ile Pro Leu Val Met. Lys Gln C:ys His Faro Asp Thr Lys Lys Phe L,eu Cys Ser Leu Phe Ala Pro Val Cys Leu Asp Asp Leu Asp Glu Thr Ile Gin Pro Cys His Ser Leu Cys 'Jal Gln 11G 11~ 120 Va7. Lys Asp Arg Cys Ala Pro Va1 Met 5er Ala Phe Gly Phe Pro Trp Pro Asp Met Leu Giu Cys AsL Arq Phe Pro Gln Asp Asn Asp 190 14 ~~ 150 Leu Cys Ile Pro Leu Ala Ser Ser Asp Hi:I~eu Leu Pro Ala Thr 155 16() 165 Glu Glu Ala Pro Lys Val Cys Glu Ala Cys hys Asn Lys Asn Asp Asp Asp Asn Asp Ile Met Glu Th: heu Cys Lys Asn Asp Phe Ala 18~, 190 195 Leu Lys Ile Lys Val Lys Glu IlF, Thr Ty.r Ile Asn Arg Asp Thr 200 20'210 Lys Ile Ile Leu Glu Thr Lys Ser Lys Thr Ile Tyr Lys Leu Asn Giy Val Ser Glu Arg Asp Leu Lys Lys Ser Val Leu Trp Leu Lys Asp Ser Leu Gln Cys Thr C.'ys Glu Glu Met Asn Asp Ile Asn Ala Pro Tyr Leu Val Met Gly Cain Lys Gln Gly Gly Glu Leu Val Ile Thr Ser Val Lys Arg Trp Gln Lys G1y Gln Arg Glu Phe Lys Arg Ile Ser Arg Ser I1e Arg Lys Leu Gln Cys 290 2cri <210> 416 <211> 21 e212> DNA
<213> Artificial ~:220>
<221> Artificial Sequence <222> 1-27.
<223> Artificial Sequence <400> 416 cctggctcgc tgctgctgct c 21 <210> 9i7 <211> 25 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> :'~-25 <22:3> Artificial Sequence <400> 41i cctcacaggt gcactgcaag ctgtc 25 <210> 918 <211> 47 <2i2> DNA
<213> Arta.ficial <220>
<221> Artificial Sequence <222> 1-47 <223> Artificial Sequence <400> 418 ctcttcctct ttggccagcc cgacttctcc tacaagcgca gaattgc 4'7 <210> 419 <211> 7830 <212> DNA
<213> Homo Sapiens <900> 419 gtggaggccg ccgacgatgg cggggccgac ggaggccgag acggggtt.gg 50 ccgagccccg ggccctgtgc gcqcagcggg gcc:accgCac ctacgcgc;gc 100 cgctgggtgt tcctgctcgc gatcagcctg ctc~aactgct ccaacgcc;ac 150 gctgtggctc agctttgcac ctgtggctqa cgtcattgct gaggacttgg 200 tcctgtccat ggagcagatc aacac7gctgt cactagtcta cctcgtggta 250 tccaccccat ttggcgtggc ggc:catctgg atcctggact ccgtcgggct 300 ccgtgcggcg accatcctgg gtgcgtggct qaactttgcc gggagtgtgc 350 tacgcatggt gccctgcat.g gtt:gttgctga cccaaaaccc atttgccttc 900 ctcatgggtg gccagagcct ctgtgccctt gcccagagcc tggt:catct.t 450 ctctccagcc aagctggctg ccttgtggtt cccagagcac cagcgagcca 500 cggccaacat. gctcgccacc atc7tcgaacc ctctgggcgt ccttgtggcc 550 26~

aatgtgctgt: cccctgtgct ggtcaagaa~ ggtgaggaca ttccgttaat 600 gctcggtgtc: tataccatcc ctgctggcgi: c.gtca gcctg ctgtccacca 650 tctgcctgtq ggagagtgtg ccccccaccc~ cgccctctgc cggggctgcc 700 agctccacct cagagaagtt cctggatgg:4 ctcaagctgc agctcatgtg 750 gaacaaggcc tatgtcatcc tggctgtgtg cttgggggga atgatcggga 800 tctctgccag cttctcagcc ctcctggagc agat=cctctg tgcaagcggc 850 cactccagtg ggttttccgg cctctqtggc gctctcttoa tcacgtttgg 900 gatcctgggg gcactggctc tcggcc:ccta tgtc~gaccgg accaagcac:t 950 tcactgaggc c:accaagatt ggcctgtgcc tgttctctct ggcctgcgt:g 1000 ccctttgccc tggtgtccca gctgcaggga cagacccttg c:cctggctclc 1050 cacctgctcg ctgctcgggc tgtt=tggctt ctcggtgggc c:ccgtggcc:a 1100 tggagttggc ggtcgagtgt tcct~tcccc:g tgggggaggg ggctaccac~a 1150 ggcatgatct ttgtgctggg gcaggccgag ggaatactca 1=catgctggc 1200 aatgacggca ctgactgtgc gacgctcgc.a gccgtc:cttg tccacctgcc 1250 agcaggggga ggatccactt gactggacag tqtctctgct gctgatggcc 1300 ggcctgtgca ccttcttcag ctg:.atcctg gcggtc:ttct tccacacccc 1350 ataccggcgc ctgcaggccg agtctgggcta gcccccctcc ac:ccgtaacg 1400 ccgtgggcgg cgcagactca gggccgggtg tggaccgagg gggagcagga 1950 agggctgggg tcctggggcc cagcacgg~:g actccggagt gc:acggcgag 1500 gggggcctcg ctagaggacc ccagagggcc cgggagcc:cc cacccagcct 1550 gccaccgagc gactccccgt gcgcaaggc:c cagcagccac cgacgcgccc 1600 tcccgccccg gcagaca cgc aggcagggT~c c:aagcgtcca gg tttattga 1650 cccggctggg totcactcct ccttctcc~c cccgtgggtg atcacgtagc 1700 tgagcgcctt gtagtccagg ttccccgc-;:a catcgatgga ggcgaactgg 1750 aacatctggt ccacctgcgg gcgggggcga aagggctcct tgcggqctcc 1800 gggagcgaat tacaagcgcg cacct.gaaaa 1830 <210> 420 <211> 5E0 <212> PRT
<213> Homo Sapiens <40C> 920 Met Ala Gly Pro Thr G1u Ala Glu Thr Gly Leu Ala Gl.u Pro Arg Ala Leu Cys Ala Gln Arg Gly His Arg Thr Tyr Ala Arg Arg Trp 20 c:5 30 Val Phe Leu Leu Ala Iie Ser Leu Leu Asn Cys Ser Asn Ala Thr Leu Trp Leu Ser Phe Ala Pro Val Ala F~sp Val Ile Ala C-l.u Asp Leu Val Leu Ser Met Glu Gln Ile Asn 1.'rp Leu Ser Leu Va1 Tyr Leu Val Val Ser Thr Pro Phe Gly Val Ala Ala Ile Trp Ile Leu Asp Ser Val Gly Leu Arg Ala Ala Thr Ile Leu Gly Ala Trp Leu 9'.i L00 105 Asn Phe Ala Gly Ser Val Leeu Arq Met Val Pro C;ys Met: ~~'al Val Gly Thr Gln Asn Pro Phe A:a Pha Leu Met Gly Gly Gln Ser Leu Cys Ala Leu Ala Gln Ser Lf~u Val Ile Phe Ser Pro Ala Lys Leu 190 14,~ 150 Ala Aia Leu Trp Phe Fro Glu His Gln Arc( Ala Thr Ala Asn Met Leu Ala Thr Met Ser Asn Pro Let: Gly Va7_ Leu Val Ala Asn Val Leu Ser Pro Val Leu Val Lys Ly:; G1y Glu Asp Ile Pro Leu Met 185 19(1 195 Leu Gly Val Tyr Thr I.Le Pro Ala.: Gly Val Val Cys Leu Leu Ser 200 20'~~ 210 Thr Ile C:ys Leu Trp Glu Ser Va. Pro Pro Thr Pro Pro Ser Ala 215 22.7 225 Gly Ala Ala Ser Ser Thr Ser Glu Lys Ph~~ Leu Asp Gly Leu Lys Leu Gln Leu Met Trp Asn Lys A1~3 T'yr Val lle Le a Ala Val Cys 245 25t'? 255 Leu Gly Gly Met Ile Gly Ile Se.r Aia Ser Phe Ser Ala Leu Leu Glu Gln Ile Leu Cys Ala Ser Gly His Ser Ser Gly Phe Ser Gly 275; 280 285 Leu Cys Gly Ala Leu Phe Lle Thr Plie Gly Ile Leu Gly Ala Leu Ala Leu Gly Pro Tyr Val Asp Arg Thr Lys His Phe Thr Glu Ala Thr Lys Ile Gly Leu Cys Leu Phe Ser Leu Ala Cys Val Pro Phe Ala Leu Val Ser Gln Leu Gln Gly Gln Thr Leu Ala Leu Ala Ala 26( Thr Cys Ser I_,eu Leu Gly Leu Phe Gly Fhe Ser Val Gly Pro Val Ala Met Glu Leu Ala Val Glu Cys Ser Fhe Pro Val Gly Glu Gly Ala Ala Thr Gly Met I12 Phe Val Leu C~ly G:n Ala Glu Gly Ile 380 ,85 390 Leu Ile Met Leu Ala Met Thr Ala Leo Thr Val Arg Arg Ser Glu Fro Ser Leu Ser Thr Cys Gln Gln G1y Glu Asp Pro Leu Asp Trp Thr Val Ser Leu Leu Leu Met Ala Gly Leu Cys Thr Phe Phe Ser Cys Ile Leu Ala Val Phe Ptue His Thr Prc Tyr Arg Arg Leu Gln Ala Glu Ser Gly Glu Pro Pro Ser Thr Arg Asn I'~la Vai C;ly Gly Ala Asp Ser Gly Pro Gly Val Asp: Arg Gly Gly Ala C;ly Arg Ala 970 47~=. 480 Gly Val Leu Gly Pro Ser Thr Ala Thr Pro Glu Cys Thr Ala Arg Gly Ala Ser Leu Glu Asp Pro Arc: Gly Pro Gly Ser Faro His Pro Ala Cys His Arg Ala Thr Pro Arg Aia Gln Gly Pro Ala Ala Thr Asp Ala Pro Ser Arg Pro G.Ly Ar<I Leu Ala Gly Arg Val Gln Ala Ser Arg Phe Ile Asp Pro A.la Gly Ser Hi:: Ser Ser Phe Ser Ser Pro Trp Val Ile 'Thr <210> 421 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <900> 421 agcttctcag ccctcctgga gcag 24 <210> 422 <211> 25 <212> DNA
<213> Artificial 26i <220>
~:221> Artificial Sequence <222> 1-25 <223> Artificial Sequence <900> 422 cgggtcaata aacctggacg cttqg 25 <210> 923 <:211> 43 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-43 <223> Artificial Sequence <900> 423 tatgtggacc ggaccaagca ctt.cactgag gccacc:aaga Ltg 43 <210> 424 <211> 9313 <212> DNA
<213> Homo Sapiens <900> 424 gtcccacatc ctgctcaact gggtcaggt.c cctct~agac cagctcttgt 50 ccatcatttg ctgaagtgga ccaactagtt ccccagtagg gggtctcccc 100 tggcaattct tgatcggcgt ttggacatc,t cagat~~gctt ccaatgaaga 150 tggccttgcc ttggggtcct gcttgtttca taatcatcta actatgggac 200 aaggttgtgc cggcagctct gggggaagc;a gcacggggct gatcaagcca 250 tccaggaaac actggaggac ttgtccag c ttgaaagaac tctagtggtt 300 tctgaatcta gcccacttgg cggtaagcat gatgcaact.t ctgcaacttc 350 tgctggggct tttggggcca ggt:ggctac.~t tat:ttctt_t..t aggggattgt 400 caggaggtga ccactctcac ggtgaaatac caagtgtcag aggaagtgcc 450 atctggtaca gtgatcggga agc:tgtccca ggaactgggc cgggaggaga 500 ggcggaggca agctggggcc gccttccagg tgttgcagct gcctcaggcg 550 ctccccattc aggtggactc tgaggaaggc ttc~ctcagca caggcaggcg 600 gctggatcga gagcagctgt gcc:gacagtg ggatccct.gc ctggttt,:ct 650 ttgatgtgct tgccacaggg gat.ttggctc tgatccatgt ggagatccaa 700 gtgctggaca tcaatgacca ccagccacgg tttcccaaag gcgagcagga 750 gctggaaatc tctgagagcg cctc~ctc;cg aaccc:ggatc c:ccctggac;a 800 gagctcttga cccagacaca ggccctaaca ccctgcacac ctacactctg 850 tctcccagtg agcactttgc cttggatetc attgtgggcc ctgatgagac 900 26c caaacatgca gaactcatag tggtgaagga gctggacagg gaaatccatt 950 cattttttga tctggtgtta actgcctatg ac:aatgggaa <:ccccccaag 1000 tcaggtacca gcttggtc:aa ggtc:aacgtc ttggactcca atgacaatag 1050 ccctgcgttt gctgagagtt cactggcact ggaa atccaa cfaagatgctg 1100 cacctggtac gcttctcata aaacagaccg ccacagaccc t:gaccaagc~c 1150 cccaatgggg aggtggagtt cttrc~caCt aagcac:atgc <a ccagaggt 1200 gctggacacc ttcagtattg atgc:c~aag~ac aggccaggtc attctgcgtc 1250 gacctctaga ctatgaaaag aacc:ctgcct acgaggtc:ga t=gtt<:aggca 1300 agggacctgg gtcccaatcc tat.cccagec cattg<:aaag ttctcatcaa 1350 ggttctggat gtcaatgaca acatccca<ag cat.cca cgtc acatgggcct 1900 cccagccatc actggtgtca gaagctcttc ccaaggacag ttttattgct 1450 cttgtcatgg cagatgactt ggattcagya cacaat.ggt.t tggtccactg 1500 ctggctgagc caagagctgg gccacttcGzg gctgaaaaga actaatggca 1550 acacatacat gttgctaacc aatgccaca c tggacagaga gcagtggccc 1600 aaatataccc tcactctgtt agcccaag:~c caagga ctcc agcccttatc 1650 agccaagaaa cagctcagca ttcagatc;ig t gacatcaac gacaatgcac 1700 ctgtgtttga gaaaagcagg tatgaagt~:t c;:acg.:ggga aaacaactta 1750 ccctctcttc acctcattac catcaagg:~t catgatgcag acttgggcat 1800 taatggaaaa gtctcatacc gcatccagga ctccccagtt gctcacttag 1850 tagctattga ctccaacaca ggagaggtca ctgctcagag gtcactgaac 1900 tatgaagaga tggccggctt tgagt.tccag gt<~atcg:ag aggacagcgg 1950 gcaacccatg cttgcatcca gtgtctctgt gtgggtcagc ctcttggatg 2000 ccaatgataa tgccccagag gtggt:ccagc ctgtgctcag cgatggaaaa 2050 gccagcctct ccgtgcttgt gaatgcctcc acaggccacc tgctggtgcc 2100 catcgagact cccaatggct. tgggc:ccagc gggcactgac acacctccac 2150 tggccactca cagctcccgg ccattccttt tgacaa<:cat. tgtggcaaga 2200 gatgcagact cgggggcaaa tggagagccc <:tctacagca tccgcaatgg 2250 aaatgaagcc cacctcttca tcctcaaccc tcatacgggg cagcagttcg 2300 tcaatgtcac caatgccag<: agcctcat tg ggagt.gagtg ggagctggag 2350 atagtagtag aggaccaggg aagc~ccrvcc ttacagaccc gagccctgtt 2400 gagggtcatg tttgtcacca gtgtgga<:ca c:ctg<igggac tcagcccgca 2950 2 6'-?

agcctggggc cttgagcatg tcg<itgctga c:c~gr_gatctg cctggctgta 2500 ctgttgggca tcttcgggtt gatc;ctggct to gt:tcatgt ccatctgccg 2550 gacagaaaag aaggacaaca gggcctacaa ctgtcgggag accgagtcca 2600 cctaccgcca acagcccaag aggc:cc:caga aacacattca gaaggcagac 2650 atccacctcg tgcctgtgct caggggtcag gcaggtgagc catgt:gaagt 2700 cgggcagtcc cacaaagatg tggacaagga ggcgatgatg gaagcaggct 2750 gggacccctg cctgcaggcc ccct:tccacvc tcaccc:cgac cctgtacagg 2800 acqctgcgta atcaaggcaa ccagggagca ccggcqgaga gccgagaggt 2850 gctgcaagac acggtcaacc tcc~:tttc«a ccatcccagg cagaggaatg 2900 cctcccggga gaacctgaac cttc:ccgac:c cccagc;ctgc cacaggccag 2950 ccacgttcca ggcctctgaa ggttgcagcc agcccc:acag ggaggctggc: 3000 tggagaccag ggcagtgagg aag~cccac:a gaggc<:acca gcctc:ctctg 3050 caaccctgag acggcagcga catctcaat.g gcaaa<7tc~tc cc:ctgagaaa 3100 gaatcagggc cccgtcagat cctgcggactc ctggtc:cggc tgtctgtggc 3150 tgccttcg<:c gagcggaacc ccgtggagga gctcactgtg gattctcctc: 3200 ctgttcagca aatctcccag ctgctgtc~::t tgctgcatca gggccaattc 3250 cagcccaaac caaaccaccg aggaaataag tacttggcca agccaggagg 3300 cagcaggagt gcaatcccag aca<:agat«g ccc:aagtgca ag ggctggag 3350 gccagacaga cccagaacag gaggaagggc ctttggatcc tgaagaggac 3400 ctctctgtga agcaactgcr_ agaaaaagag ctgtcaagtc tgctggaccc 3450 cagcacaggt ctggccctgg accggctgag cgc:ccctgac ccggcctgga 3500 tggcgagact ctctttgccc ctcac:cacca act:accatga caatgtgatc 3550 tccccggatg ctgcagccac ggaggagcc:g aggaccttc:c agacgttc:gg 3600 caaggcagag gcaccagagc t.gagcccaac aggcac:gagg ctggccac,aca 3650 cctttgtctc ggagatgagc tcact:gctgg agatgctgct ggaacagcgc 3700 tccagcatgc ccgtggaggc cgcctccaag gcg ctgcggc ggctctcggt 3750 ctgcgggagg accctcagtt tagacttggc caccagtgca gcctcaggca 3800 tgaaagtgca aggggaccca ggtggaaaga cgggga ctga gggc:aagagc 3850 agaggcagca gcagcagcag cagg,-_gcctg tgaac:atacc rcagacgc ct 3900 ctggatccaa gaaccagggg cctgaggatc tgtggacaag agctggtttc 3950 taaaatcttg taactcacta gctagcgrcg gcctgagaac tttagggtga 9000 ctgatgctac ccccacagag gagg~aaUag cccc<sggact aacagctgac 4050 G 71) tgaccaaagc agccccttgt aagcagctct gagtcttttg gaggacaggg 4100 acggtttgtg gctgagataa gtgtttcctg gcaaaacata tgtggagcac 4150 aaagggtcag tcctctggca gaacagatgc cacggagtat c:acaggcagg 9200 aaagggtggc ctt.cttgggt agcaggagt;~ agggggctgt accctggggg 9250 tgccaggaaa tgctctctga cctatcaata aaggaaaagc agtaaaaaaa 9300 aaaaaaaaaa aaa 9313 <210> 425 <211> 1184 <212> PRT
<213> Hcmc sapiens <400> 925 Met Met Gln Leu Leu Gln Lau Lei: Leu Gly Leu Leu Gly Pro Gly Gly Tyr Leu Phe Leu heu Gly Asp Cys Gln C;lu '~,lal. Thr 'rhr Leu Thr Val Lys Tyr Gln Val Ser Glu Glu Vaa Pro Ser c~ly Thr Val 35 9(~ 45 Ile Gly Lys Leu Ser Gln Gl.u Lets Gly Arcx C;lu Glu Arg Arg Arg (~ 5 !':~ 6 0 Gln Ala Gly Ala Al.a Phe Gln Vas I_,eu Gln Leu Prc Gln Ala Leu Pro I 1e C;ln Val Asp Ser C.lu Gl az Gly Leiz Leu Ser Thr Gly Arg Arg Leu Asp Arg Glu Gln Leu Cys Arg Gln Trp Asp Fro Cys Leu Val Ser Phe Asp Val Leu Ala Thr G1y Asp Leu Ala Leu Ile His Val Glu Ile Gln Val Leu Fap I12 Asn Asp His Gln Pro Arg Phe Pro Lys Gly Glu Gln Glu Leu Glu Ile Ser Glu Ser Ala Ser Leu Arg Thr Arg Il.e Pro Leu I~sp Arg Ala Leu Asp Fro Asp Thr Gl.y Pro Asn Thr Leu His Thr Tyr Thr Leu Ser Pro Ser G1u His Phe 170 1i5 180 Ala Leu Asp Val Ile Val. (~ly Pro Asp Glu Thr Lys His Ala Glu 18.5 190 195 Leu Ile Val Val Lys Glu Leu A:p Arg Glu Ile His Ser Phe Phe Asp Leu Va1 Leu Thr Ala 'iyr Asp Asn Gly Asn Pro Pro Lys Ser 215 2'<?0 225 2 7 :!

Gly Thr Ser Leu Val_ Lys Val Asn Val. Leu Asp Ser Asn Asp Asn 230 '~35 290 Ser Pro Ala Fhe Ala Glu Ser Ser Leu Ala Leu Glu Ile Gln Glu 295 25~ 255 Asp Ala Ala Pro Gly Thr Leu Leu Iie Lye 1:eu Thr Ala Thr Asp Pro Asp Gln Gly Prc Asn G:Ly Glt: Val Glu Phe Phe Leu :per Lys 2_75 280 285 His Met Pro Pro Glu Val Lceu AsP Thr Phe Ser Ile Asp Ala Lys Thr Gly Gln Val Ile heu Arg Arc; Pr~J Leu Asp Tyr Glu Lys Asn 305 31c) 315 Pro Ala Tyr Glu Val Asp Va:31 Gln Ala Arca Asp Leu Gly Pro Asn 320 32', 330 Pro Ile Pro Ala His Cys Lys Vas Leu Ilc~ Lys Val Leu Asp Val Asn Asp Asn ile Pro Ser Ile Hi> Val Th:r Trp .Ala Ser Gln Pro Ser Leu Val Ser Glu Ala Leu Pr..; Lys Asp Ser Phe Ile Ala Leu Val Met Ala Asp Asp Leu Asp Sec Gly His Asn Gly Leu Val His Cys Trp Leu Ser Gln Glu Leu G1~,~ His Phe Arg Leu Lys Arg Thr Asn Gly Asn Thr Tyr Me~ Leu Le~.~ Thr Asn Ala Thr Leu Asp Arg 410 41r> 420 Glu Gln Trp Pro Lys Tyr Thr Leu Thr Leu Leu Ala Gln Asp Gln Gly Leu Gln Pro Leu Ser A1<f Lys Lys Gln Leu Ser Ile Gln Ile Ser Asp Ile Asn Asp Asn Ala Pro Vai Phe Glu Lys Ser Arg Tyr Glu Val Ser Thr Arg Glu Asn A:n Leu Pro Ser Leu His Leu Ile 470 9i5 480 Thr Ile Lys Ala His Asp Ala A::p Leu Gly Ile Asn Gly Lys Val Ser Tyr Arg Ile Gln Asp .'3er Pro Val Al.a His Leu Val Ala Ile Asp Ser Asn Thr Gly Glu Val TY:r Ala Gln Arg Ser Leu Asn Tyr 515 5a0 525 Glu Glu Met Ala Gly Phe Glu Ptie Gln V<il Ile Ala G.lu Asp Ser Gly Gln Pro Met Leu Ala Ser Ser Val Ser Val. Trp Val ~er Leu Lea Asp Ala Asn Asp Asn Ala Prc Gl.u Val Va.l Gln Pro Val Leu Ser Asp Gly Lys Ala Ser Leu Ser Val. Leu Val Asn Ala Ser Thr 57~; 580 585 Gly His Leu Leu Val Pro Ile Glu T'hr Prc Asn C:ly Leu Gly Pro Ala Gl.y Thr Asp Thr Pro Pro Let: A.Ia Thr His >er Ser Arg Pro Phe Leu Leu Thr Thr Ile Val Ala Arg Asp Ala Asp Ser Gly Ala E;20 62'_; 630 Asn Gly Glu Pro Leu Tyr Ser IlE Arg Asn C~ly Asn Glu Ala His Leu Phe Ile Leu Asn Pro H:is Thr Gly Glrn Leu 1?he Val Asn Val 650 65': 660 Thr Asn Ala Ser Ser heu Ile G11~ Ser Glu Trp Giu Leu Glu Ile Val Val Glu Asp Gln Gly Ser Prc~ Pro Leu Gln 'Thr Arg Ala Leu Esc 6a5 690 Leu Arg Val Met Phe Val Thr Se_ Val Asp His Le:u Arg Asp Ser Ala Arg Lys Pro Gly Ala Leu SeY Met 5er Met Leu Thr Va7. Ile 710 71~ 720 Cys Leu Ala Val Leu Leu Gly I1~.. Phe Gly Leu Ile Leu Ala Leu 72 ~ 730 735 Phe Met 5er Il,e Cys Arg Thr Glu Lys Lys Asp Asn Arg Ala Tyr Asn Cys Arg Glu Ala Glu Ser Thr Tyr Arg Gln G.ln Pro Lys Arg 755 '760 765 Pro Gln Lys His Ile Gln Lys Al.a Asp Ile His Leu Val Pro Val Leu Arg Gly Gln Ala Gly Glu Pro Cys Glu Val. Gly Gln Ser His Lys Asp Val Asp Lys Giu Ala Met Met Glu Al,a Gly Trp Asp Pro Cys Leu Gln Ala Pro Phe His LEU 'I'hr Pro Thr Leu Tyr Arg Thr Leu Arg Asn Gln Gly Asn Gln Gly Ala Pro Ala Glu Ser Arg Glu 830 8~~5 840 Val Leu Gln Asp Thr Val flsn Leu Leu Phe Asn His Pro Arg Gln 895 8_'>0 855 Arg Asn Ala Ser Arg G.lu A:.n Leu Asn Leu Pro Glu Pro Gln Pro Ala Thr Gly Gln Pro Arg Ser Arg Fro Leu hys Val Ala Gly Ser Pro Thr Gly Arg Leu Ala G7y Asp G1n Gly Ser Glu Glu P.la Pro Gln Arg Pro Fro Ala Ser Sm Ala Thr Leu Arg Arg Gln Arg His Leu Asn Gly Lys Val Ser Pro Glu Lys GlL Ser Gly Pro I:rg Gln Ile Leu Arg Ser heu Val Arg Leu Ser Val A1a Ala Phe Ala Glu Arg Asn Pro Val Glu Glu Leu Thr Val AsF; Ser Pro Pro 'Jal Gln 950 95_'> 960 Gln Ile Ser Gln Leu Leu Ser Lei: Leu His Gln Gly G1n Phe G1n Prc Lys Pro Asn His Arg Gly Asn Lys Tyr Leu Ala hys Pro Gly Giy Ser Arg Ser Ala Ile Fro AsFa Thr Asp Gly Pro Ser Ala Arg Ala Gly G1y Gln Thr Asp Pro G1u Gln G1u Gl.u Gly Pro Leu Asp 1010 101.' 1020 Pro Glu Glu Asp Leu Ser Val Lys Gln Leu Leu Glu Glu Glu Leu Ser Ser heu Leu Asp Pro Ser Th~. Gly Lea Ala Leu Asp Arg Leu Ser Ala Pro Asp Pro Ala Trp Me:_ Ala Arg Leu Ser Leu Pro Leu Thr Thr Asn Tyr Arg Asp Asr_ Val Ile Ser Pro Asp Ala Ala Ala Thr Glu Glu Pro Arg Thr F'he GlTLur Phe Gly Lys Ala Glu Ala Pro Glu Leu Ser Pro Thr Gly 'I'hr Arg Leu A1a Ser Thr Phe Val Ser Glu Met Ser Ser Leu l.,et: Glu Met. Leu Leu Glu Gln Arg Ser Ser Met Pro Val Glu Ala A1<3 SE:r Glu Ala Leu Arg Arg Leu Ser Val Cys Gly Arg Thr Leu Ser Leu Asp Leu Ala Thr Ser Ala Ala 1195 11_'~0 1155 Ser Gly Met Lys Val Gln Gly Asp Pro Gly Gly Lys Thr Gly Thr '_160 1165 1170 Glu Gly Lys Ser Arg G.ly Ser Sex Ser ;>er Ser Arg Cys Leu 1175 1.'L80 <210> 426 <211> 29 <212> DNA
213> Artificial <220>
'221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <400> 426 gtaagcacat gcctccagag gtga 29 <210> 927 <211> 29 <2i2> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-29 <223> Artificial Sequence <400> 427 gtgacgtgga tgcttgggat gttg 29 <2i0> 928 <21.1> 50 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-50 <223> Artificial Sequence <900> 928 tggacacctt cagtattgat gccaagacag gcc:aggtcat tctgcgtcga 50 <210> 429 <211> 2037 <212> DNA
<213> Homo sapiens <400> 429 cggacgcgtg ggcggacgcg tggg<lgagag ccgcagtccc ggctgcagca 50 cctgggagaa ggcagaccgt gtgagggggc ctgtgg<:cc:c agcgtgctgt 100 ggcctcgggg agtgggaagt ggaggcaqga gccttcctta cacttcgcca 150 tgagtttcct catcgactcc: agc:a~catga tt:acc:tc:cca gatacta~tt 200 tttggatttg ggtggctttt ct~~catgcgc caatt.gttta aagactatga 250 gatacgtcag tatgttgtac aggtgatott ctccgtgacg tttgcatttt 300 cttgcaccat gtttgagctc atcatctttg aaatcatagg agt<~ttgaat 350 2 7 '~

agcagctccc gttattttca ctggaaaatg aacctgtgtq taattctgct 400 gatcctggtt ttcatggtgc ctt2ttacat: t:qgctatttt ~;ttgtgagca 450 atatccgact actgcataaa caac:gactac ttttttcctc~ tctcttatgg 500 ctgaccttta tgtatttctt ctgga<~acta gga~~atcc;ct t tcc:c:attc:t 550 cagcccaaaa catgggatct tatc:cataga acagct.catc agccgggttg 600 gtgtgattgg agtgactctc atg~~c~_cttc tttctc~ga:~ti- ?:ggtgctgtc 650 aactgcccat acacttacat gtcvtacttc ctcag<ta<itg t gact.gacac: 700 ggatattcta gccctggaac ggcga~,tgct gcaaac:catg c3atat:gatca 750 taagcaaaaa gaaaaggatg gcaatggca,c qgagaacaat qttccagaag 800 ggggaagtgc ataacaaacc atcaggtt?.c tggggaatga ~aaaaagtgt 850 taccacttc;a gcatcaggaa gtgaaaat<:.t tactct:tatt :~aacaggaag 900 tggatgcttt ggaagaatta agcaggcagc tLtttctgga aacagctgat 950 ctatatgcta ccaaggagag aatagaat<~c tc caaaacct tcaaggggaa 1000 atattttaat tttcttggtt_ actttttc?:c tatttactgt gtttggaaaa 1050 ttttcatggc taccatcaat attgtttttg atcgagttgg gaaaacggat 1100 cctgtcacaa gaggcattga gatcactgt:g aattatct.gg g<iatccaatt 1150 tgatgtgaag ttttggtccc~ aacacatt'c c:ttcattctt gttggaataa 1200 tcatcgtcac atccatcaga ggattgctga tcactcttac caagttcttt 1250 tatgccatct ctagcagtaa gtcctccaat gt<:attgtcc tgctattagc 1300 acagataatg ggcatgtact ttqtctcc;.c tqt:gctqctg atccgaatga 1350 gtatgcecttt agaataccgc accataatca ct:~aagtcca tggagaactg 1900 cagttcaact tctatcaccg ttqgt:ttgat gtgatcttcc tggtcagcgc 1950 tctctctagc atactcttcc tctatttggc tc~acaaacag gcaccagaga 1500 agcaaatggc accttgaact taagcctact acagactgtt agaggccagt 1550 ggtttcaaaa tttagatata agag<3gggga aaaatggaac cagggcc?.ga 1600 cattttataa acaaacaaaa tgctatggta gcatttttca ccttcatagc 1650 atactccttc: cccgtcaggt gat:ac tatga ccatgagtag catcagccag 1700 aacatgagag ggagaactaa ctcaagacaa tactc:agcag agagcatccc 1750 gtgtggatat gaggctggtg tagaggcgga gaggagccaa gaaactaaag 1800 gtgaaaaata cactggaact= ctggggcaag acatgtctat ggtagctgag 185C
ccaaacacgt aggatttccg ttttaagcrt.t cacatggaaa aggttatagc 1900 tttgccttga gattgactca tt:aaaatc:ag agaci:gtaac aaaaaaaaaa 1950 27v aaaaaaaaaa agggcggccg cgacactaga gtcgacctgc agaagcttgg 2000 ccgccatggc ccaacttgtt tatt.gcagct tataatg 2037 <210> 430 <211> 455 <2,12> PRT
<213> Homo sapiens <400> 930 Met Ser Phe Leu Ile Asp Ser Ser Il.e Met Ile Thr Ser ~:~lr: Ile Leu Phe Phe Gly Fhe Gly Trp Lea: Phe Fhe Met Arg Gln Leu Phe 2 0 2 .'> 3 0 Lys Asp Tyr Glu Ile Arg Gln Tyn Val Val Gln 'Jal Ile Phe Ser Val Thr E'he Ala Phe Ser Cys Th:- Met Phe Gla Leu Ile Ile Fhe Glu Ile Leu Gly Val Leu Asn Se:- Ser 5er Arg Tyr Phe His Trp Lys Met Asn Leu Cys Val Ile Lea Leu Ile Leu Val Phe Met Val Pro Fhe Tyr Ile Gly Tyr Phe Ile Val Ser Asn Ile Arg Leu Leu His Lys Gln Arg Leu Leu Fhe Ser Cys Leu Leu Trp Leu Thr Phe Met Tyr Phe Phe Trp Lys I_eu Gly Asp Pro Phe Fro Ile Leu Ser Pro Lys His Gly Ile Leu Ger Il= Glu Gln Leu Ile Ser Arg Val Gly Val Ile Gly Val Thr Leu Met Ala Leu Leu Ser Gly Phe Gly Ala Val Asn Cys Pro T'yr Thr Tyr Met Ser Tyr Phe Leu Arg Asn Val Thr Asp Thr Asp Ile Leu Ala Leu Glu Arg Arg Leu Leu Gln Thr Met Asp Met Ile Tle :~er Lys Lys Lys Arg Met Ala Met Ala 200 2Ci5 2.10 Arg Arg Thr Met Phe Gln ~~ys Gly Glu Val. His Asn Lys Pro Ser 215 2~.'0 225 Gly Phe Trp Gly Met Ile Lys Seer Val Thr Thr Ser Ala Ser Gly Ser Glu Asn Leu Thr Leu Ile G'n Gln Glu Val Asp Ala Leu Glu Glu Leu Ser Arg Gl.n Leu Phe LE~u Giu Thr Ala Asp Leu Tyr Ala 27'i 260 a?65 270 Thr Lys Glu Arg Ile Glu Tyr Ser Lys "Chr Phe L,ys Gly Lys Tyr Phe Asn Phe Leu Gly Tyr Phe Phe Ser :Cle Tyr C.'ys Val Trp Lys 290 .?95 300 Ile Phe Met Ala Thr Ile Asn Il.e Val Phe Asp Arg Val c~ly Lys Thr Asp Prc Val Thr Arg G7y Ile Gltr Ile Thr Val Asn syr Leu 320 32C~ 330 Gly Ile Gln Fhe Asp Val Lys PhE Trp Ser Gln C~is Ile Ser Phe 33_': 39C? 345 Ile Leu Val Gly ile Ile Ile Va? Thr Ser Ile Arg Gly Leu Leu Ile Thr Leu Thr Lys Phe Ph a Tyr A).a Ile Ser Ser Ser ~ys Ser 365 37C? 375 Ser Asn Val Ile Val heu Leu Leu Ala Gln Ile Met Gly Met. Tyr Phe Val Ser Ser Val Leu Leu Ilt~ Arg Met= Ser Met Pro Leu Glu Tyr Arg Thr ile Ile Thr Glu Va.l. heu Gly Glu Leu Gln Phe Asn 910 41','~ 920 Phe Tyr His Arg Trp Phe Asp Va? Ile Phe Leu Val Ser Ala Leu Ser Ser Ile Leu Phe Leu Tyr Letr A.la His hys Gln Ala Pro Glu Lys Gln Met Ala Frc <210> 431 <211> 907 <212> DNA
<21.3> Homo Sapiens <220>
<221> unsure <222> 78, 81, 113, 157, 224, 297 <223> unknown base <90C> 431 catgggaagt ggagccggag ccitccttac actcgccatg agtttcct;.ca 50 tcgactccag catcatgatt acc:tcccnga nactattttt tggatttc~gg 100 tggcttttct tcngcgccaa tgtttaaaga ct:atcagata cgtcagtatg 150 ttgtacnggt gatcttctcc gtgacgtttg cc<~ttt:c:ttg caccatgl_tt 200 gagctcatca tctttgaaat cttnggacta ttgaatagca gctcccgtta 250 ttttcactgg aaaatgaacc tgtg-gtaat tctgctgatc ctggttntca 300 tggtgccttt ttacattggc tattttattg tgagcaatat ccgactactg 350 cataaacaac gactgctttt tt.cc tc~tctc ttatggctga cctttatgt a 900 tttccag 407 <210> 932 <2.11> 457 <212> DNA
<213> Homo sapiens <220>
<221> unsure <222> 31, 66, 81-82, 89, 122, 1~4, 187, 232, 241, 900, 424, 427, 434 <Z23> unknow:~ base <400> 432 gtgttgccct tggggagggg aaggggagc-c nggcc<attc ctaaaatttg 50 gccaagggtt tctttnttga att:cgggtt nngnat=acct tcccagaaaa 100 tattttttgg atttggggta gntttttttc atgcgccaat ~gtttaaaga 150 ctatgagata cgtcagtatg ttgtacagcrt gatntl_ntcc gt:ga<:gtttg 200 cattttcttg caccatgttt gagctcat;va tntttgaaat ~t:taggagta 250 ttgaatagca gctcccgtta ttttcactqg aaaatgaacc tgtgtgtaat 300 tctgctgatc ctqgttttca tggtgccttt ttacattggc t.attttattg 350 tgagcaatat ccgactactg cataaaca=is gactg~~tttt ttcctgtctn 900 ttatggctga cctttatgta tttnttnt.lg aaantaggag atccctttcc 450 cattctc 457 <210> 433 <211> 20 <212> DNA
<213> Artificial <22C>
<221> Artificial Sequence <222> 1-20 <223> Artificial Sequence <400> 93.:
aagtggagcc ggagccttcc 20 <210> 434 <211> 22 <212> DNA
<213> Artificial <:220>
<221> Artificial Sequence <222> 1-22 <223> Artificial Sequence <400> 439 tcgttgttta tgcagtagtc gg 22 2 7 ~a <210> 435 211> 4"_ s212> DNA
<213> Artificial <220>
~:221> Artificial Sequence ~222> 1-91 <223> Artificial Sequence <400> 435 attgtttaaa gactatgaga tacgtc agt.a tgttgtacag c3 41 <210> 436 <211> 3951 <212> DNA
<213> Homo sapiens <900> 436 ctcgcgcagg gatcgtccca tggccgggc:rc tcggac~ccgc gacccttggg 50 gggcctccgg gatttgctac: ctttttggct ccctgctcgt cgaactgctc 100 ttctcacggg ctgtcgcctt caatctggac gtgatgggtg ccttgcgcaa 150 ggagggcgag ccaggcag cc tcttcggcr_t ctctgtggcc ctgcaccggc 200 agttgcagcc ccgaccccag agctggctgc tggtgg gtgc tccccaggcc 250 ctggctcttc ctgggcagca ggcgaatcgc act.ggaggcc tcttcgcttg 300 cccgttgagc ctggaggaga ctgactgcta cagagtggac atcgaccagg 350 gagctgatat gcaaaaggaa agcaaggaga ac<:agtggtt gggagtcagt 900 gttcggagcc aggggcctgg gg<~caagatt gtt:acc:tgtg cacaccgata 950 tgaggcaagg cagcgagtgg aceagatcct ggagacgcgg gatatgattg 500 gtcgctgctt tgtgctcagc caggacctgg ccatccagga tgagtt.gqat 550 ggtggggaat ggaagttctg tgagggacgc ccc:caaqgcc atgaacaatt 600 tgggttctgc cagcagggca cagct;gccgc c:ttctc<:cct gatagccact 650 acctcctctt tggggcccca ggaa<:ctata attggaaggg cacggccagg 700 gtggagctct gtgcacaggg ctcagcggac ctggcacacc tggacgac:gg 750 tccctacgag gcggggggag agaaggagca ggacc:cccgc ctcatcccgg 800 tccctgccaa cagctacttt ggct:ctcta ttgacac:ggg gaaaggtctg 850 gtgcgtgcag aagagctgag ctr.tgtggct ggagc:ccccc gcgccaacca 900 caagggtgct gtggtcatcc tgcg~~aagga cagcqccagt cgcctggtgc 950 ccgaggttat gctgtctggg gac~cgcctga cctcc:ggctt tggctactca 1000 ctggctgtgg ctgacctcaa cagtgatqgc tggc<:agacc tgatagtggg 1050 tgccccctac ttctttgagc gc~aagaaga gctggggggt gctgtgtatg 1100 tgtacttgaa ccaggggggt cacrgggctg ggatctcc:cc tctccggctc 1150 tgcggctccc ctgactccat gttcgggatc agcctggctg tcctggggga 1200 cctcaaccaa gatggctttc cagatattCC agtgggtgcc <:cctttgatg 1250 gtgatgggaa agtcttcatc taccatggc;a gc:agcc:tggg c~gttgtcgc:.~ 1300 aaaccttcac aggtgctgga ggg~:gaggct gtgggc;atca agagctt.cgg 1350 ctactccctg tcaggcagct tggatatgga tgggaaccaa t:accctgacc 1900 tgctggtggg caccctggct gacaccgc<g tgctci:tcag ggccagaccc: 1950 atcctccat.g tctcccatga ggtctctatt gctccacgaa gc:atcgacct 1500 ggagcagccc aactgtgctg gcggccactc ggtct<xtgtg gacctaaggg 1550 tctgtttcag ctacattgca gtccccagc:a gctat<~gc:cc tactgtggcc 1600 ctggactat:g tgttagatgc: ggacacagac cggaggctcc ggggccaggt 1650 tccccgtgtg acgttcctga gccgtaacvt ggaagaaccc aagca ccagg 1700 cctcgggcac cgtgtggctg aagcacca~;c atgaccgagt ctgtggagac 1750 gccatgttcc agctccagga aaatgtcaaa gacaagcttc gggccattgt 1806 agtgaccttg tcctacagt<: tccagacc-~c tcggctccgg cgacaggctc 1850 ctggccaggg gctgcca cca gtggcccc-~a tc:ca caat:gc ccaccagccc 1900 agcacccagc gggcagagat ccacttcctg aaqcaaggct gtggtgaaga 1950 caagatctgc cagagcaatc tgcagctggt ccacgcccgc ttctgtaccc 2000 gggtcagcga cacggaattc caacca ctgc ccatggatgt ggatggaaca 2050 acagccctgt ttgcactgag tgcgcagcca gtcattggcc tggagctgat 2100 ggtcaccaac ctgccatcgg acc:cagccca gccccaggct gatggggatg 2150 atgcccatga agcccagctc ctg gt:cat.gc ttc:ctgactc act.gcactac 2200 tcaggggtcc gggccctgga ccctgcggag aagccac:tct gcctgtccaa 2250 tgagaatgcc tcccatgttg agt.gtgagct ggggaacccc atgaagagag 2300 gtgcccaggt caccttctac ctcatcctta qcacctccgg gatcagcatt 2350 gagaccacgg aactggaggt agagctgctg ttggccacga tcagtgagca 2900 ggagctgcat ccagt:ctctg cac:gagcccg tgtcttcatt gagctgccac 2450 tgtccattgc aggaatggcc: at tccccagc aactcatctt ctct:ggtgtg 2500 gtgaggggcg agagagccat gcagtctc:ag cgggatgtgg gcagcaaggt. 2550 caagtatgag gtcacggttt ccaaccaagg ccagt:cgctc agaaccctgg 2600 gctctgcctt cctcaacat.c atgtggcca c atgagattgc caatgggaag 2650 tggttgctgt acccaatgca ggttgagctg gagggcgggc aggggcctgg 2700 gcagaaaggg ctttgctctc ccaggc:ccaa c::atcctccac c:tggatgtgg 2750 acagtaggga taggaggcgg cgggagctgg agccacct:ga gcagcaggag 2800 cctggtgagc ggcaggagcc cagc:atgtcc tg~3tggccag t.gtcctctgc 2850 tgagaagaag aaaaacatca ccctggactg cgcccggggc acggccaaca 2900 gtgtggtgt.t cagctgccca ctct:acagct ttgacc:gcgc c~gctatgcta 2950 catgtctggg gccgtctctg gaac:agcacc tt.tctggagg agtaca cage 3000 tgtgaagtcc ctggaagtga ttgtccggctc caacat:caca gtgaagtcct 3050 ccataaagaa cttgatgctc cgacaatgcct ccacagtgat cccadtgatg 3100 gt.atacttgg accccatggc tgtggtggua gaagga gtgc cctggtgggt 3150 catcctcctg gctgtact.gg ctgggctgot ggt.gclvagca ~~tgcr_ggtgc: 3200 tgctcctgtg gaagatggga ttcttcaaa:~c gggcgaagca cc:ccgaggcc 3250 accgtgcccc agtaccatgc ggtgaagatt cctcgc~gaag accgacagca 3300 gttcaaggag gagaagacgg gcaccatc~:t gaggaacaac tggggcagcc 3350 cccggcggga gggcccggat gcacacccc::a tcctgc~ctgc tgacgggcat 3400 cccgagctgg gccccgatgg gcatccag<~g ccaggi:accg cctaggttcc 3950 catgtcccag cctggcctgt ggctgccctc cat.cccttcc ccagagatgg 3500 ctccttggga tgaagagggt agagtgggrt gca ggtgtcg catcaagatt 3550 tggcaggatc ggcttcctca ggc~gcacacXa cct:ctcccac ccacaagaac 3600 tcctcccacc caacttcccc ttagagtgct gtgagatgag agtgggtaaa 3650 tcagggacag ggccatgggq tagggtgaga agggcagggg tgtcctgatg 3700 caaaggtggg gagaagggat cctaatc.c:~t tcca ctccca ttcaccctgt 3750 gtaacaggac cccaaggacc tgc:ct.ccccg gaagtgcctt aacctagagg 3800 gtcggggagg aggttgtgtc actgactcag gcvtgctcctt ctctagtttc 3850 ccctctcatc tgaccttagt ttgctegccat cagtctagtg gtttcgtggt 3900 ttcgtctatt tattaaaaaa tat:ttgagaa caaaaaaaaa aaaaaaaaaa 3950 a 3951 <:210> 437 <211> 1141 <212> PRT
<213> Homo Sapiens <400> 437 Met Ala G1y Ala Arg Ser Arg A:>p Yro Trp Gly Ala Ser Gly Ile gggtcagcga cacggaattc caacca ctgc Cys Tyr Leu Phe Gly Ser Leu Leu Val C>lu Leu L~eu Phe Ser Arg Ala Val Ala Phe Asn Leu As_p Val Met Gly Ala Leu Arg Lys Glu Gly Glu Pro G1y Ser Leu PI:e Gly Phe Ser Val Ala Leu His Arg Gln Leu G.Ln Pro Arg Pro Gln Sex Trp Leu Leu Val Gly Ala Pro b5 70 75 Gln Ala Leu Ala Leu Pro GLy Glr Gl.n Ala Asn Arg Thr Gly Gly Leu Phe Ala Cys Prc_ Leu Ser Leu Glu Glu Thr Asp Cys Tyr Arg Val Asp Ile Asp Gln Gly Al-a AsPMet- Gln Lys Glu Ser ~ys Glu 110 11~~ 120 Asn Gln Trp Leu Gly Va.1 Ser Val Arch Ser Gln C;ly Pro Gl.y Gly Lys Ile Val Thr Cys Ala His Arc; Tyr Glu Ala Arg C~In Arg Val Asp Gln Ile Leu Glu Thr Arg AsIMet Ile Gly Arg Cys Phe Val 155 16() 1.65 Leu Ser Gln Asp Leu A1a lle Arc; Asp Glu Leu Asp Gly Gly Glu 170 17w 180 Trp Lys F°he Cys Glu G1y Arg Pro Gln Gly His G1u (~ln Phe G1y Phe Cys Gln G1n Gly Thr Ala Ala Ala Phf~ :>er Pro Asp Ser His 200 2G~~ 210 Tyr Leu Leu Phe Gly Ala Pro G1;~ Thr Tyr Asn Trp Lys Gly Thr Ala Ara Val Glu Leu C:ys Ala Gle: C~ly Ser Ala Asp Leu Ala His 230 23'; 290 Leu Asp Asp Gly Pro Tyr ClL Al:j Gly Gly Glu Lys Glu Gln Asp Pro Arg .Leu Ile P.ro Val Fro Ala Asn Ser Tyr Phe Gly Phe Ser Ile Asp Ser Gly Lys Gly Leu Val Arg Ala Glu Glu Leu Ser Phe Val Ala Gly Ala Pro Arg Ala Asn His Lys Gly Ala Val Val Ile Leu Arg Lys Asp Ser Aia :;er Arg Leu Val Pro Glu Val Met Leu Ser Gly Glu Arg Leu Thr Ser Gly Fhe Gly Tyr Ser Leu Ala Val 28.

Ala Asp Leu Asn Ser Asp Gly Trp P.ro Asp heu 11e Val C)ly Ala Fro Tyr Phe Phe G'lu Arg Gln Glu Glu Leu Gly Gly Ala Val Tyr Val Tyr Leu Asn Cln Gly Gly Hi._= Trp Ala Gly lle Ser Pro Leu Arg Leu Cys Gly Ser Pro Asp Sex Met Fhe Gly lle Ser Leu Ala 380 38~~ 390 Val. Leu Gly Asp Leu Asn Gln Asp Gl;~ Phe~ Fro Asp Ile Ala Val Gly Ala Fro Phe Asp Gly Asp Gly Lys Val Fhe lle Tyr His Gly 910 91'. 920 Ser Ser Leu Gly Val Val ALa LyPrc Sei; c~ln Val heu Glu Gly Glu Ala Val G1y ile Lys Ser Phf: Gl y Tyr Ser Leu Ser t,1 y Ser 940 99': 450 Leu Asp Met Asp Gly Asn G1n Ty; Prc Asps Leu Leu Val Gly Ser Leu Ala Asp Thr Ala Val Leu Ph<e Arg Ala Arg Pro Ile Leu His 470 47!=, 480 Val Ser His Glu Val Ser Ile Ala Pro Arg Ser Ile Asp Leu Glu 48_°°. 490 995 Gln Prc Asn Cys Ala C~ly Gl.y Hi:~ Ser Val Cys Val Asp Leu Arg Val Cys Phe Ser Tyr Ile Ala VaL F'ro Ser Ser Tyr Ser Pro Thr ~:15 520 525 val Ala Leu Asp Tyr Val Leu Asr~ Ala Asp Thr Asp Arg Arg Leu 5j~ 535 590 Arg Gly Gln Val Fro Arg Val Thr E'he Leu Ser Arg Asn Leu Glu Glu Fro Lys His Gln Ala Ser Gly Thr Val Trp Leu Lys His Gln His Asp Arg Val Cys Gly Asp Ala Met Phe Gln Leu Gln Glu Asn Val Lys Asp Lys Leu Arg Ala Ile Val. Val Thr Leu Ser Tyr Ser Leu Gln Thr Fro Arg Leu Jlrg Axg Glr: Ala Pro Gly Gln Gly Leu 605 b10 615 Pro Pro Val Ala Pro Ile Leu Asn A1,.3 His Gln Pro Ser Thr Gln Arg Ala Glu Ile His Phe Leu Lys G:Ln Gly Cys Gly Glu Asp Lys Ile Cys G.Ln Ser Asn Leu Gln Leu Val His Ala Arg Phe Cys Thr 6_'~0 fi55 660 Arg Val Ser Asp Thr Glu POe Gln Pro Leu Pro Met Asp Val Asp Gly Thr Thr Ala Leu Phe Ala Leu Sei: Gly Gln Pro Val Ile Gly 680 tp85 690 Leu Glu Leu Met Val Thr Asn Leu Pro 5er Asp Pro Ala C~ln Pro 695 '700 705 Gln Ala Asp Gly Asp Asp A'~a His G.lu Ala C;ln lieu Leu Val Met 710 '715 720 Leu Pro Asp Ser Leu His Tyr Ser Gly Val Arg Ala Leu Asp Pro '~25 730 735 Ala Glu Lys Fro Leu Cys L,eu Ser Asn Giu Asn 11.a Ser His Val Glu Cys Glu Leu Gly Asn P.r.o Met Lys Arg Gly Ala Gln Val Thr Phe Tyr Leu Ile Leu Ser Thr Sen Gly Ile ::er Lle Glu 'f'hr Thr 770 77'> 780 Glu Leu Glu Val Glu Leu Leu Lei.: Ala Thr Ile Ser c~lu Gl n Glu Leu His Pro Val Ser Ala Arg Ala Arg Val Phe I1e Glu Leu Pro 800 80'. 810 Leu Ser I:le Ala Gly Met A1a I1<e Pro Gln Gln Leu Phe Phe Sex Gly Val Val Arg Gly Glu Arg Ala Met G1=~ Ser Glu Arg Asp Val 830 83':, 89U
Gly Ser Lys 'Jal hys Tyr Glu VaL I'hr Val Ser Asn Gl.n Gly Gln Ser Leu Arg Thr Leu Gly Ser Ala E'he Leu Asn I.le Met Trp Pro His Glu ile Ala Asn Gly L.ys Trp Leu Leu Tyr Pro Met Gln Val Glu Leu Glu Gly Gly Gln C;ly Pro G7y Gln Lys Gly Leu Cys Ser Pro Arg Pro Asn Ile Leu His Leu Asp Val Asp Ser Arg Asp Arg Arg Arg Arg Glu Leu Glu lero Pro Giu Gln Gln Glu Pro Gly Glu Arg Gln Glu Pro Ser Met Ser Trp Trp Pro Val Ser Ser Ala Glu Lys Lys Lys Asn Ile Thr Leu Asp Cys Ala Arg G1y Thr Ala Asn 950 9'_~5 960 GH_J

CysVai ValPheSerCysProLeufyrSer PheF~spArgAlaAla ValLeu HisValfrpGlyAr-gLeu'frpAsn SerThrPheLeuGlu 980 9g5 990 GluTyr SerAlaValLysS<-.rLeisGll.iVal IleValArgAlaAsn il.eThr ValLysSerSerIieLy:AsnLeu MetheuArgAspAla SerThr ValIleProValMetVa1TyrLeu AspProMetALaVal Va1ALa GluGlyValFroTrpTrp~Va1Il<=L,euLeuAlaVa1Leu 1090 7.045 1050 AiaGly LeuLeuValLeuAl.aLei.iLeuVa.1LeuLeuLeuTrpLys MetGIy PhePheLysArgAlaLy:,HisPro GluAiaThrValPro GlnTyr HisAlaValLysIlePryArgGlu AspArgGlnGlnPhe LysGlu GluLysThrGly'fhrIlaLeuArg i~snAsnTrpGlySer 1100 7.105 1110 ProArg ArgGluGlyProAspAlaHisPro IleLeuAlaAlaAsp GlyHis ProGluLeuGLyProAsr%GIyHis Pr:oGlyProGlyThr Ala <210> 938 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-29 <223> Artificial Sequence <:900> 938 ggctgacacc gcagtgctct tcag 29 <210> 939 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-29 <223> Artificial Sequence <400> 439 28n gctgctgggg actgcaatgt agcy 29 <210> 440 <211> 46 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-46 <223> Artificial Sequence <400> 440 catcctccat gtctcccatg aggtctcte:~t tqctcc:ac:ga agcatc 96 <210> 941 <211> 1969 <212> DNA
<213> Homc> Sapiens <400> 441 cgcgccgggc gcagggagct gagt.ggaccXg ctcgagac.gg cggcgcgtgc 50 agcagctcca gaaagcagcg agttggcaga gcaggc~ctgc atttccagca 100 ggagctgcga gcacagtgct. ggctcacaac aagatgctca aggtgtcagc 150 cgtactgtgt gtgtgtgcag ccgcttgg~ag cagtca gtct ctcgcagctg 2U0 ccgcggcggt ggctgcagcc ggggggcggt cggacggcgg taattttctg 250 gatgataaac aatggctcac cacaatct~:t caatatgaca aggaagtcgg 300 acagtggaac aaattccgag acgaagtaga ggatgattat ttccgcactt 350 ggagtccagg aaaacccttc gatcaggctt tagatccagc taaggatcca 900 tgcttaaaga tgaaatgtag tcgccataaa gtatgcatt.g ctcaagat.tc 450 tcagactgca gtctgcatta gtc:ac:cgg.ag gcttacacac aggatgaaag 500 aagcaggagt agaccatagg cagtggaggg gtc:ccatatt atccacctgc 550 aagcagtgcc cagtggtcta tccvcagccct gtt=tgtggtt cagatggt:ca 600 tacctactct tttcagtgca aactagaata tcaggcatgt gtcttaggaa 650 aacagatctc agtcaaatgt gaaggacatt gcc:cat.gtcc ttcagataag 700 cccaccagta caagcagaaa tgt.taagaga qcatgcagtg acctggagtt 750 cagggaagtg gcaaacagatt.gcgggac:tg gttcaaggcc cttcatgaaa 800 gtggaagtca aaacaagaag acaaaaacat tgctgaggcc tgagagaagc 850 agattcgata ccagc:atctt gcc:aatttgc aaggactcac ttggctggat 900 gtttaacaga cttgatacaa actatgacct gctattggac cagtcagagc 950 tcagaagcat ttaccttgat aagaatg<;ac agtgt:accaa ggcattcttc 1000 aattcttgtg acacatacaa ggacagtt.ta atatc:taata atgagtggtg 1050 ctactgcttc cagagacagc aagcicc;cacc tt gcc~.gact ctagctcagca 1100 atattcagaa gcggcaaagg gtoaaclaaac tcctaqgac<-i cttataaccc:c 1150 ctgtgtgatg aagatggtta cta~:~a~sgcca acacaatc~tc atggc:agtgt 1200 tggacagtgc tggtgtgttg acagatatc:g aaatgaaatc atgggatcca 1250 gaataaatgg tgttgcagat tgtg ctatag attttgagat ctccggagat 1300 tttgctagtg gcgattttca tgaatggaot gatgat:gagg atgat:gaaga 1350 cgatattat.g aatgatgaag atgaaattga agatgatgat gaagatgaag 1400 gggatgatga tgatggtggt gatc~accat.g atgtatacat ttgattgatg 1950 acagttgaaa tcaataaatt ctacatttct aatatr.taca aaaatgatag 1500 cctatttaaa attatcttct.. tccccaataa caaaatgatt ctaaacctca 1550 catatatttt gtataattat ttgaaaaatt gcagctaaag tt:atagaact 1600 ttatgtttaa ataagaatca tttgctttra gtt.tttatat tccttacaca 1650 aaaagaaaat acatatgcag tctagtcaga caaaataaag ttttgaagtg 1700 ctactataat aaatttttca cgagaacaaa ct:t:tgtaaat cttccataag 1750 caaaatgaca gctagtgc:tt gggatcgtac atgttaatt.t tttgaaagat 1800 aattctaagt gaaatttaaa ataaataa:~t ttttaatgac ctgggtctta 1850 aggatttagg aaaaatatgc atgct:ttaat tgcatttcca aagtagcatc 1900 ttgctagacc tagatgagtc agrataacag agagatacca catgactcca 1950 aaaaaaaaaa aaaa 1969 <210> 942 <211> 936 <21.2> PRT
<213> Homo sapiens <400> 442 Met Leu Lys Val Ser Ala Va1 Le~u Cys Val Cys Ala Ala Ala Trp Cys Ser Gln Ser Leu Ala Al,s Ala A1<~ A7a Val Ala Ala Ala Gly Gl.y Arg Ser Asp Gly Gly Asn Pt:e Leu A:;p Asp Lys Gln Trp Leu Thr Thr Il.e Ser Gln Tyr Asp Lys Glu Va1 Gly Gln Trp Asn Lys 50 _'~5 60 Phe Arg Asp Glu Vai Glu Asp A:>p Tyr Phe Arg Thr Trp Ser Pro Gly Lys Pro the Asp Gln Ala Lt:~u Asp Pro Ala Lys Asp Pro Cys 80 ,5 90 Leu Lys Met Lys Cys Ser Arg His Lys Val Cys Ile Ala Gln Asp Ser Gln Thr Ala Val Cys Iie Ser His Arg Arg Leu Thr His Arg Met Lys GIu Ala Gly Val Asp His Arg Gln Trp Arg Gly Pro Ile Leu Ser Thr Cys Lys Gl.n Cys Prc Vai Val Tyr I'ro Ser Pro Val 140 14'. 150 Cys Gly Ser Asp Gly His Thr Tyr Ser Phe Gln Cys Lys Leu Glu I55 16C) 165 Tyr Gln Ala Cys Val Leu Gly Lye G1:~ Ile Ser Val hys (~ys Glu Gly His Cys Pro Cys Pro Ser Asp Lys Pro T hr :per Thr Ser Arg 185 19(.~ 195 Asn Val Lys Arg Ala Cys Ser Ash Leu Glu I'he Arg ('~lu Val Ala zoo 2 c~-, 210 Asn Arg Leu Arg Asp Trp Fhe Lys Ala Leu His Glu Ser Gly Ser 27.5 220 225 Gln Asn Lys Lys Thr Lys Thr Le,a Leu Arg I'ro Glu Arg Ser Arg Phe Asp Thr Ser Ile Leu Pro Ile Cys Lys Asp Ser Leu Gly Trp Met Fhe Asn Arg Leu Asp Thr Asn Tyr Aso Leu Leu Leu Asp Gln Ser Glu Leu Arg Ser Ile Tyr Leu Asp Lys Asn Glu Gln Cys Thr Lys Ala Phe Phe Asn Ser Cys Asp 'I'hr Tyr Lys Asp Ser Leu Ile Ser Asn Asn Glu Trp Cys Tyr Cys Phe Gln Arg Gln Gln Asp Pro 30'~ 3I0 315 Pro Cys Gln Thr Glu I_,eu Ser Asn ile Gl.n Lys Arg Gln Gly Val 32(7 325 330 Lys Lys Leu Leu Gly Gin "'yx: Ile Pro Leu Cys Asp Glu Asp Gly Tyr Tyr Lys Pro Thr Gln Cy:: His Gly Ser Val Gly Gln Cys Trp Cys Val Asp Arg Tyr Gly flSI7 Glu Val Met Gly Ser Arg Ile Asn 36'> 3i0 375 Gly Val Ala Asp Cys Ala Tle Asp Phe Glu Ile Ser Gly Asp Phe 380 38,5 390 Ala Ser Gly Asp Fhe His c:;lu Txp Thr A;~p Asp Glu Asp Asp Glu Asp Asp Ile Met Asn Asp Glu Asp Glu Ile Glu Asp Asp Asp Glu 28!?

Asp Glu Gly Asp Asp Asp Asp Gly Gly Asp Asp His Asp Val Tyr 925 ~3C 935 lle <210> 493 <211> 25 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-25 <223> Artificial Sequence <400> 443 cagcaatatt cagaagcggc aaggg 25 <210> 999 <211> 28 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-28 <223> Artificial Sequence <400> 444 catcatggtc atcaccacca tcatcatc 28 <210> 445 <211> 48 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-98 <:223> Artificial Sequence <900> 995 ggttactaca agccaacaca atgtcatgg c agtgttggac agtgctgg 98 <210> 946 <211> 3617 <212> DNA
<:213> Homo sapiens <900> 446 cagactccag atttccctgt= caa ccacgag gagtc;cagag aggaaacgcg 50 gagcggagac aacagtacct~ gacgcctctt tcagc:ccggg atcgccccag 100 cagggatggg cgacaagatc tggctgccct tcccc:gtgct ccttctggcc 150 gctctgcctc cggtgctgct= gccagggqcg gccgc~ct:tca c.accttccct 200 cgatagcgac ttcaccttta cccttccc:gc cggcc~agaag gagtgcttct 250 accagcccat gcccctgaag gcctcgctgg agatcgagta ccaagtttta 300 gatggagcag gatt.agatat tgatttccat ctt.c~cctct.r cagaaggcaa 350 aaccttagtt tttgaacaaa gaaaat;caga t=ggagt.tc:ac actgtagaqa 400 ctgaagttgg tgattacatg ttctgc:tttg aca<3tacatt cagcaccatt 450 tctgagaagg tgattttctt tgaattaatc ctggataata t:.gggagaar_a 500 ggcacaagaa caagaagatt ggaagaaata tattactc~gc <,icagatatat 550 tggatatgaa actggaagac atcctggaat ccatcaac:ag <;atcaagt<;c 600 agactaagca aaagtgggca catacaaatt ctgcttacaag c:atttgaagc 650 tcgtgatcga aacatacaaq aaagcaactt tgatagagtc aatttctggt 700 ctatggttaa tt,tagtggtc atggtggtgg tgtcagccat tcaagtttat 750 atgctgaaga gtctgtttga agataagac_ag aaaagt..agaa ~ataaa«ct:c 800 caaactagag tacgtaacat tgaaaaatga ggcat<iaaaa ~gcaataaac 850 tgttacagtc aagaccatta atggtctt<a ccaaa<statt ttgagatata 900 aaagtaggaa acaggtataa ttttaatgt_g «aaat~..aagt cttcactttc 950 tgtgcaagta atcctgctga tccagttgta cttaagtgtg taacaggaat 1000 attttgcaga atataggttt aac:tgaatga agccatatta ataa~ctgcat 1050 tttcctaact ttgaaaaatt ttgcaaat~xt ctt.aggtgat ttaaataaat 1100 gagtattggg cct:aattgca acaccagtat gtt.tttaaca ggttctatta 1150 cccagaactt ttttgtaaat gcggcagtt:a caaattaact gtggaagttt 1200 tcagttttaa gttataaatc ac<vtgagaat tac:ctaatga tggattg«at 1250 aaatctttag actacaaaag cccaactttt ctca atttac atatgcatct 1300 ctcctataat gtaaatagaa taatagcttt ga<iatacaat taggtttttg 1350 agatttttat aaccaaatac at.tt<;agtgt aacatattag cagaaagcat 1400 tagtctttgt actttgctta cat.t<:ccaaa agctgacatt ttc«cgattc 1450 ttaaaaacac aaagttacac t.tact:aaaat taggacatgt tttctctttg 1500 aaatgaagaa tatagtttaa aagcttcctc ctccataggg acacattttc 1550 tctaaccctt aactaaagtg taggatttta aaattaaatg tgaggtaaaa 1600 taagtttatt tttaatagta tctg-:.caagt taatatc.tgt caacagttaa 1650 taatcatgtt atgttaattt taacatgatt gctgacttgg ataattcatt 1700 attaccagca gttatgaagg aaatattgct aaaat:gatct gggcctac:ca 1750 taaataaata tctccttttc tgagctct.aa gaatt:at:cag aaa«caggaa 1800 agaatttaga aaaacttgag aaaa:cctaat ccaaaataaa att:cacttaa 1850 29t gtagaactat aaataaatat ctagaatctg actggcacat <:atgacatc~c 1900 tactcataac ataaatcaaa ggagatgatt aatttc:cagt tagctggaag 1950 aaactttggc tgtaggtttt tatt:ttctac aagaattctg c~tttgaatta 2000 tttttgtaag caggtacatt ttataaaat g taagc<:ctac i=gtaaggttt 2050 agcactgggt gtacatattt attaaaaatt tttati_atas caactttt.at 2100 taaaatggc:c tttctgaaca ctttatttat tgatgttgaa gtaaggatta 2150 gaaacataga ctcccaagtt ttaaacacc.;t aaatg=gaat ~aacccatata 2200 tacaacaaag tttctgccat ctagcttttt= gaagtctatg ggggtcttac: 2250 tcaagtacta gtaatttaa<: ttcatcatga atgaa~aata atttttaagr_ 2300 tatgcccatt tataacgttg ttt.atgacaa cattgtgagt tagaaacaaa 2350 cttaaaattt ggggtataga acc:cctcaac aggttagtaa tgctggaatt 2900 cttgatgagc aataatgata accagagagt g<~t.ttcat.tt ac:actcatag 2450 tagtataaaa agagatacat ttc:cctctta ggc:ccctggg agaagagc:ag 2500 cttagatttc cctactggca aggtt.tttaa aaatgaggta aatgccgtat 2550 atgatcaatt accttaattg gccaagaaaa tgc:ttcaggt gtctaggggt 2600 atcctctgca acacttgcag aac:aaaggt.c aat=aagatcc ttgcctat.ga 2650 atacccctcc cttttgcgct gtta<iattt=.g caatgagaag caaatttaca 2700 gtaccataac taataaagca gggtacagat ataaactact gcatcttttc 2750 tataaaactg tgattaagaa ttctacctct cctgtatggc tgttactata 2800 ctgtactctc tgact:cctta cctaacaatg aatttgt-tac ataatctrct 2850 acatgtatga tttgt.gccac: tgatc:ttaaa cctatgattc agtaacttct 2900 taccatataa aaacgataat tgc;tttattt ggaaaagaat ttaggaatac 2950 taaggacaat tatttttata gacaaagtaa aaagacagat atttaagagg 3000 cataaccaaa aaagcaaaac ttgtaaa<:ag agt:aaaaatc tttaatattt 3050 ctaaagacat actgttt.atc tg~.:ttcat.at gcttt=tttta att.tcactat 3100 tccatttcta aattaaagtt atgctaaactt gagta agog tttatca:~tt 3150 aacagctcat. tttgtctttt tcaatataca aattl~taaaa atactacaot 3200 atttaactaa ggcccaaccg atttccat:.aa tgtagcagtt accgtgttc:a 3250 cctcacacta aggcctagag tttgctct..ga tatg~~atttg gatgattaat= 3300 gttatgctgt tctttcatgt gaatgtcaag acatggaggg t=gtttgtaat 3350 tttatggtaa aattaatcct tcttacacat aatggtgtct taaaattgac 3900 aaaaaatgag cacttacaat tgtc~tgtctc ctcaaatgaa gattctttat 3950 gtgaaatttt aaaagacatt gattccgcat gtaaggattt t.tcatctgasa 3500 gtacaataat gcacaatcag tgttgctcaa actgcttt.at acttataaac 3550 agccatctta aataagcaac gtattgtgag tactgatatg t.atataataa 3600 aaattatcaa aggaaaa 3617 <21C> 997 <211> 229 <212> PRT
<21:.~> Homc: Sapiens <400> 497 Met Gly Asp Lys Ile T.rp Leu Pro Phe Pro Val Leu Leu Len Ala Ala Leu Fro Pro Val. Leu Leu Pr~:~ Gl.y Ala Ala Gly Phe Thr Pro Ser Leu Asp Ser Asp Phe Thr Pht:~ Thr Leu Pro A1a Gly Gln Lys Glu Cys Phe Tyr Gln Prc Met Prro Leu Lys Ala Ser Leu Glu Ile Glu Tyr Gln Val Leu Asp Gly Ala Giy Leu Asp I1e Asp Phe His Leu Ala Ser Pro Glu Gl.y Lys Thr Leu Val Phe Glu Gln Arg Lys Ser Asp Gly Val His Thr Vat. G7u Thr Glu Val Gly Asp Tyr Met Phe Cys Phe Asp Asn Thr Phe Ser Thr Ile Ser Glu Lys Val Ile Phe Phe Glu Leu Ile Leu Asp ASn Met Gly Glu Gln Ala Gln Glu 12'_u 130 135 Gin Glu Asp Trp Lys Lys 'ry~° Ile 'Phr Gly Thr Asp Ile Leu Asp Met Lys Leu Glu Asp Ile :,eu G7u Ser Ile Asn Ser Ile Lys Ser 155 1E>0 165 Arg Leu Ser Lys Ser Gly His I~e Gln I7.e Leu Leu Arg Ala Phe 170 l.'s 180 Glu Ala Arg Asp Arg Asn Ile Gin Glu Ser Asn Fhe Asp Arg Val 185 1~a0 195 Asn Phe Trp Ser Met Val Asn Lc-'u Val Val Met. Val. Val Val Ser Ala Ile Gln Val Tyr Met Leu Lys Ser Lc=u Phe Glu Asp Lys Arg Lys Ser Arg Thr ~~210> 948 <211> 23 <212> DNA
<:'l'j> P.rtificia;
<:220>
<221> Artificial Sequence <222> 1-23 <~223> Artificial Sequence <400> 948 cccagcaggg ctgggcgaca aga 23 <210> 499 <211> 23 <21.2> DNA
<213> Artificial <220=>
<221> Artificial Sequence <222> 1-23 <223> Artificial Sequence <400> 449 gtcttccagt ttcatatcca ata 23 <210> 950 <211> 93 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-43 <223> Artificial Sequence <400> 450 ccagaaggag cac:ggggaag ggc:agccaga tc_~ttgtc:gcc cat 4 3 <210> 451 <211> 859 <212> DNA
<213> Homo Sapiens <900> 451 ccatccctga gatcttttta taaaaaaccc agtctttgct gaccagacaa 50 agcataccag atctcaccag agagtcgcag acact.atgct gcct_cccatg 100 gccctgccca gtgtgtcctg gatgctgctt tcctgcctca ttct.cctgtg 150 tcaggttcaa ggtgaagaaa cccagaar.ga actgc:cctct ccac:ggatca 200 gctgtcccaa aggctccaag gcctatgcrct cccccagcta tgcc:ttgttt 250 ttgtcacc:aa aatcctggat ggatgcacrat ctgg<vttgcc agaagcggcc 300 ctctggaaaa ctggtgtctg tgctcag=gg ggctgaggga tccttcgr_gt 350 cctccctggt gaggagcatt agtaaca~~ct actcatacat ctggattggg 900 ctccatgacc ccacacaggg ctc:tgagcct gatggagatg gatg ggagtg 950 gagtagcact gatgtgatga attactttgc atgggagaaa aatccctcca 500 ccatcttaaa ccctggccac tgtclggagcc tgt.caagaag cacaggattt 550 ctgaagtgga aagattataa ctgtgatgca aagttaccct aitgtctgcaa 600 gttcaaggac tagggcaggt gggaagtcag cagcct.cagc t_tggcegtge:a 650 gctcatcatg gacatgagac cagt:.gtga~zg act=caccctg daagagaata 700 ttctccccaa actgccctac ctgactacc~t tgtcat.gatc ca ccttcttt 750 ttcctttttc tt.caccttca tttcaggcit ttctct:gtct tccatgtctt 800 gagatctcag agaataataa taaaaatg~t actttataaa aaaaaaaaaa 850 aaaaaaaaa 859 <2i0> 952 <211> 175 <2i2> PRT
<213> Homc.~ sapiens <400> 452 Met Leu Pro Pro Met. Al.a L,eu Pro Ser Val Ser Trp Met Leu Leu Ser Cys Leu Ile Leu Leu (:'ys Gln Val Gln Gl.y G1u Glu Thr Gln Lys Glu Leu Pro Ser Pro Arg Ile Ser Cys Pro Lys Gly Ser Lys Ala Tyr Gly Ser Pro Cys Tyr Ala Leu Phe Leu Ser Pro Lys Ser Trp Met Asp Ala Asp Leu Ala Cys Gln Lys Arg Fro Ser Gly Lys Leu Val Ser Val Leu Ser Gly Ana Glu Gly Ser Phe Val Ser Ser 80 E',5 90 Leu Val Arc Ser Iie Ser .Asn S<-~r Tyr Se:r Tyr Ile Trp Ile Gly G5 1 ()0 105 Leu His Asp Fro Thr Gln Gly Ser Gl.u Pro Asp Gly Asp Gly Trp 1i0 1'15 120 Glu Trp Ser Ser Thr Asp Val Mot Asn Tyr Phe Ala Trp Glu Lys i25 130 135 Asn Pro Ser Thr Ile Leu Asn Pro Gly His Cys Gly Ser Leu Ser Arg Ser Thr Gly Phe Leu Lys Trp Lys Asp Tyr Asn Cys Asp Ala 155 160 7.65 Lys Leu Pro Tyr Val Cys Lys Phe Lys Asp <210> 953 <211> 550 <212> DNA
<213> Homo Sapiens <900> 453 ccagtctgtc gccac:ctcac: ttgg~gtctg ctgtccccgc caggcaagcc 50 tggggtgaga gcacagagga gtggc~ccggg accatgcggg ggacgcggct 100 ggcgctcctg gcgctggtgc tggctgcctg cggagagctg gcgccggccc 150 tgcgctgcta cgtctgtccg gacacccacag gagtgtcgga ctgtgtcacc 200 atcgccacct gcaccaccaa cgaaaccatg t:gcaagacca cactctactc 250 ccgggagata gtgtacccct tcc:aggggga ctc:cacggtg accaagtcct 300 gtgccagcaa gtgtaagccc tcgg<itgtgg atggcatcgg ccagaccc:tg 350 cccgtgtcct gctgcaatac tgagctgtgc aatgtagacg gggcgcccgc 900 tctgaacagc ctccactgcg gggccctcac gctcctccca ctcttgaqcc 450 tccgactgta gagtccccgc ccacccccat ggccctatgc ggcccagccc 500 cgaatgcctt gaagaagtgc ccc:ctgcacc aggaaaaaaa aaaaaaaaaa 550 <210> 959 <211.> 125 <2i2> PRT
<213> Homo sapiens <900> 959 Met Arg Gly Thr Arg Leu Ala Le~.~ Leu Ala Leu Val Leu Ala Ala 1 ' 10 15 Cys Gly G1n Leu Ala Pro Ala Leu Arq Cys Tyr Val Cys Pro G1u Pro Thr Gly Val Ser Asp Cys Val Thr Ile Ala Thr Cys Thr Thr ~5 40 95 Asn G1u 'Chr Met Cys Lys Thr The Leu Tyr Ser Arg Glu Ile Va1 Tyr Pro Phe Gln Gly Asp Ser Thr Val Thr Lys Ser Cys Ala Ser Lys Cys Lys Pro Ser Asp Val Asp Gly Ile Gly Gln Thr Leu Pro Va1 Ser Cys Cys Asn Thr Glu Leu Cys Asn Val Asp Gly Ala Pro Ala Leu Asn Ser Leu His C'ys Gl~~ Ala Leu Thr Leu Leu Pro Leu Leu Ser Leu Arg Leu l~~
<210> 455 <211> 1518 <21.2> DNA
<213> Homo Sapiens <9co> 455 ctgcagtcag gactctggga ccgcaggggg ctccc.ggac c ctgactctgc 50 agccgaaccg gcacggtttc gtggggaccc aggcttgcaa agtgacggtc 100 attttctctt tctttctccc tcitctagtcc ttctgagatg atggctctgg 15C
gcgcogcggg agctacccgg gtc_:tt:tgtcg c:gatggtagc ggcggctcac 200 ggcggccacc ctctgctggg agtgagcgcc accttgaact cggttctcaa 250 ttccaacgct atcaagaacc tgcccccacc gctgggcggc gctgcggggc 300 acccaggctc tgcagtcagc gccgcgccgg gaatcctgta cccgggcggg 350 aataagtacc agaccatt.ga caactaccag ccgtacccgt gcgcagagga 400 cgaggagtgc ggcactgatg agtactgcgc tagtcccacc cgcggagggg 450 acgcaggcgt gcaaatctgt ctcgcctgca ggaagcgccg aaaacgctgc 500 atgcgtcac g ctatgtgctg ccccggga:~t tactgcaaaa atggaatatg 550 tgtgtcttct gatcaaaatc atttccgagg agaaat.tgag gaaaccatca 600 ctgaaagctt tggtaatgat catagcac<a tggatgggta ttccagaaga 650 accaccttgt cttcaaaaat gtatcacac:c aaaggacaag aaggttctgt 700 ttgtctccgg tcatcagact gtgcctcagg attgtgttgt gct.agacact 750 tctggtccaa gatctgtaaa cct:gtcct::3a aagaaggtca agtgtgtacc 800 aagcatagga gaaaaggctc tcatggacta gaaat,attcc agcgttgtta 850 ctgtggagaa ggtctgtctt gccggataca gaaagatcac catcaagcca 900 gtaattcttc taggcttcac acttgtcaga gacactaaac cagct.atcca 950 aatgcagtga actcctttta tataatagat gctatgaaaa ccttttatga 1000 ccttcatcaa ctcaatccta aggatatac::a aqttctgtgg tttcagttaa 1050 gcattccaat aacaccttcc: aaaaacctcrg agtgtaagag ct:ttgtttct 1100 ttatggaact cccctgtgat tgcagtaaat tactgtattg taaattctca 1150 gtgtggcaca tacctgtaaa tgcaatgaa:~a cttttaatta tttttct.aaa 1200 ggtgctgcac tgcctatttt, tcctcttgtt: atgta<iattt ttgtacacat 1250 tgattgttat cttgactgac aaatattcta tattgaactg aagtaaatca 1300 tttcagctta tagttcttaa aagcataa<:c cttt.ac cc.ca -ttaattcta 1350 gagtctagaa cgcaaggatc tcttggaatg acaaatgata ggtacctaaa 1900 atgtaacatg aaaatact.ag cttattttct gaaatgtact atcttaatgc: 195C
ttaaattata tttcccttta ggctgtgat.a gttttt:gaaa taaaatttaa 1500 catttaaaaa aaaaaaaa 1518 ?_97 <210> 956 <211> 266 <212> PRT
<213> Homo Sapiens <900> 956 Met Met Ala Leu G1y Ala Ala Gly Ala Thr Arg Val Fhe Val Ala i ~ 10 15 Met Val Ala Ala A1a Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr Leu Asn Ser Val Leu AsrSer Asn Ala Ile Lys Asn Leu Pro Fro Pro Leu Gly Gly P.la Ai.a Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro Gly Ile Leu Tyr Frc Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr Gln F'ro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr ('ys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys Frc: Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn Asp His Ser Thr Leu Asp Gly 'yr Ser Arg Arg Thr Th_ Leu Ser Ser Lys Met Tyr His 170 1.7.~ 180 Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser Ser Asp Cys Ala Ser Gly Leu Cys C:ys Ala Arca His Php '1'rp Ser Lys Il.e Cys 200 20.'~ 210 Lys Pro Val Leu Lys G.lu Gl.y Glm Val Cy;~ I'hr Lys His Arg Arg 21' 220 225 Lys Gly Ser His Gly L~eu Glu Ilf, Phe Gln Arg Cys Tyr Cys Gly 230 23.'5 290 Glu Gly Leu Ser Cys Arg Ile Glr: Lys Asp His His Gln Aia Ser 29' 250 255 Asn Ser Ser Arg Leu His Thr Cy: Gin Arc3 His <210> 957 <211> 638 <212> DNP.
<213> Homo sapiens <220>
<221> unsure <222> 30, 123, 133, 139, 180, a:14, 259, 282, 308, 95'2, 967, 471, 973, 509, 556 <223> unknown base <400> 457 tgtgtttccc tgcagtcaga atttgggacn gcaggggttc ccggacctga 50 ttttgcagcg gaacgggaag gtttrgtc~gg acccaggttg aaatgacc~gt 100 catttttttt tctttctcct tcnggagtcc ttntgagang atggttttgg 150 gcgcagcggg agctaacccg gtt-ttttgtn gcgat.ggtag cggcggtttt 200 cggcggccac cttntgctgg gagtgagcgc caccttgaat cggttttcaa 250 ttccaacgnt atcaagaacc: tgcccccacc gntgggcggc gctgcggggc 300 acccaggntt tgcagtcagc gccgcgccgg gaatcctgta cccgggcggg 350 aataagtacc agaccattga caatt=accag ccgtacc:cgt gcgcagagga 400 cgaggagtgc ggcactgatg agtactgcgc tagtcccacc cgcqgagggg 450 angcgggcgt gcaaatntgt ntragcct.gca ggaagcgccg aaaacgctgc 500 atgcgtcang ctatgtgctg ccccgggaat tactgcaaaa atggaatatg 550 tgtgtnttct gatcaaaatc atttccgagg agaaattgag gaaacc:atca 600 ctgaaagctt tggtaatgat catagcacct tggatggg 6r'.8 <210> 458 <211> 4040 <212> DNA
<213> Homo sapiens <400> 458 gaggaaccta ccggtaccgg ccgcgcqctg gtagtcgccg gtgtggctgc 50 acctcaccaa tcccgtgcgc cgcggctggg ccgtcggaga gtgcgtgtgc 100 ttctctcctg cacgcggtgc ttaggctcgg ccaggcgggg tccgccgc:ca 150 gggtttgagg atgggggagt agctacagga aqcgaccccg cgatggcaag 200 gt:atattttt gtggaatgaa aacrgaagtat tagaaatgag ct:gaagac:ca 250 ttcacagatt aatatttttg gggacagatt tgtgatgctt gattcaccct 300 tgaagtaatg tagacagaag ttctcaaat:t tgcatattac atcaactgga 350 accagcagtg aatcttaatg ttcacttaaa tcagaacttg cataagaaag 400 agaatgggag t~tggttaaa taaagatgac t.<3t=atcagag acttgaaaag 950 gatcattctc tgttttctga tagtgtatat ggccatttta gtgggcacag 500 atcaggattt ttacagttta cttggagtgt c.caaaactgc aagcagtaga 550 '299 gaaataagac aagctttcaa gaaattgoca ttgaagttac atcctgataa 600 aaacccgaat aacccaaatg cacatggoga t:tttt taaaa ataaatagag 650 catatgaagt actcaaagat gaagatctac ggaaaaagta tgacaaatat 700 ggagaaaagg gacttgagga taat~~aaqgt ggccagtat:g aaagctggaa 750 ctatt:atcgt tatgattttg gtatttatga tgatqatcct gaaatcat=aa 800 cattggaaag aagagaattt gatgctgc:tg ttaatt<:tgg agaactgtgg 850 tttgtaaatt tttactcccc aggctgttca cactgccatg atttagctcc 900 cacatggaga gactttgcta aa:~aagtGga tgggttactt cgaattgqag 950 ctgttaactg tggtgatgat aga atgcttt qccgaatgaa aggagtcaac 1000 agctatccca gtctcttcat ttttcggtct ggaatggccc cagtgaaata 1050 tcatggagac agatcaaagg aga gtttagt gagttttgca atgcagcatg 1100 ttagaagtac agtgacagaa cttt<xgacag qaaattttgt caactccata 1150 caaactgctt ttgctgctgg tattggctgg ctgatcactt tttgttcaaa 1200 aggaggagat tgtttgactt cacagacacg actcaggctt agtggcatgt 1250 tgtttctcaa ctcattggat gcta<jagaaa tat=atttgga agtaatac:at 1300 aatcttccag attttgaact actttcggca aacacactag aggatcgttt 1350 ggctcatcat cggtggctgt tattt:ttt~a ttt=tggaaaa aatgaaaatt 1900 caaatgatcc tgagctgaaa aaactaaaaa ctctacttaa aaatgatcat 1450 attcaagttg gcaggtttga ctgttcctct gcaccaqaca tctgtagtaa 1500 tctgtatgtt tttcagc:cgt ct<:tagcagt at.ttaaagga caaggaacca 1550 aagaatatga aattcatcat ggaaagaaga ttca atatga tatacttgcc 1600 tttgccaaag aaagtgtgaa ttctcatgtt accacgcttg gacctcaaaa 1650 ttttcctgcc aatgacaaag aac:catggct tgttgatttc tttgccccct: 1700 ggtgtccacc atgtcgagct ttactaccag agt:tacgaag agcatcaaat 1750 cttctttatg gtcagcttaa gtttggtaca ctagattgta cagttcatga 1800 gggactctgt aacatgtata acattcagcxc ttatccaaca acagtggtat 1850 tcaaccagtc caacattcat gagtatgaag gacatcactc tgctgaacaa 1900 atcttggagt tcatagagga tcttatga~t ccttc~~gtgg tctcccttac 1950 acccaccacc ttcaacgaac tagttaca<;a aagaaaacac aacgaagtct 2000 ggatggttga tttctattct ccgtggtgr_c atccttgcca agtcttaatg 2050 ccagaatgga aaagaatggc ccggacatva actggactga tcaacgtggg 2100 cagtatagat tgccaacagt atcattcttt ttgtgcccag gaaaacgttc 2150 aaagataccc tgagataaga ttttttcccc c:aaaatcaaa taaagcttat 2200 cagtatcaca gttacaatgq tt-~gaatag9 qatgcttatt c:cctgagaat 2250 ctggggtcta ggatttttac ctcaagtatc cacaqatcta acacctcaaa 2300 ct:ttcagtga aaaaqttct<i caagg ga<:aa atcattqgqt gattgatt.tc 2350 tatgctcctt ggtgtggacc ttgccagaat tt=tgctccag aatttgagct 2400 cttggctagg atgattaaag gaaaagtaaa agctqgaaaa gtaqactgtc 2950 aggcttatgc: tcagacatgc caqaaagctg ggatcagggc ctatccaact 2500 gttaagtttt atttctacga aaqagcaaag agaaattttc aagaagagca 2550 gataaatacc agagatgcaa as<~caatcgc tqccttaata agtgaaaaat 2600 tggaaactct ccgaaatcaa ggc:aagagga ataaggatga actttgataa 2650 tgttgaagat gaagaaaaaq tttaaaagaa attctgacag atgacatcag 2700 aagacaccta tttagaatgt tacatttatg atgggaatga atgaacatta 2750 tcttagactt gcagttgtac tgccagaatt atctacagca ctggtgtaaa 2800 agaagggtct gcaaactttt tctgt:aaagg gccggtttat aaatatttta 2850 gactttgcag gctataatat atggttcaca catgagaaca agaatagagt 2900 catcatgtat tctttgttat tt:~ct:tttaa c:aaccttt.aa aaaatattaa 2950 aacgattctt agctcaqagc catac:aaaag taggctqgat tcagtccatg 3000 gaccatagat tgctgtcccc ctcgacggac ttataatgtt tcaggtggct 3050 ggcttgaaca tgagtctqct gte:ct.atcta c:ataaatgtc taagttgtat 3100 aaagtccact ttcccttcac gtttt:ttggc tgacctgaaa agaggtaact 3150 tagtttttgg tcacttgttc tcctaaaaat qctatcccta accatatatt 3200 tatatttcgt tttaaaaaca ccc:at:gatgt. ggcacagtaa acaaaccc:tg 3250 ttatgctgta ttattat:gag gaqattcttc att=gttttct ttccttctca 3300 aaggttgaaa aaatgctttt aatttttcac agccgagaaa cagtgcaqca 3350 gtatatgtgc acacagtaag tacacaaatt tgagcaacag taagtgcaca 3400 aattctgtaq tttgctgtat catccaggaa aac:ctgaggg aaaaaaatta 3950 tagcaattaa ctgggcattg tagagtatcc taaatatqtt atcaagtatt 3500 tagagttcta tattttaaag atatatgt~t tcatgtat:tt tctgaaattg 3550 ctttcataga aattttccca ctgatagttg atttttgagg catctaatat 3600 ttacatattt gccttctgaa ctttgtttag acctgtatcc tttatttaca 3650 ttgggttttt ctttcatagt tttggttt~t caca cctqtc cagtct.attt 3700 attattcaaa taggaaaaat tactttacag gttgttttac tgtagcttat 3750 aatgatactg tagttattcc agtta ctagt ttact.gtcag agggctgcct 3800 ttttcagata aatattgaca taataactga agttattttt ataagaaaat 3850 caagtatata aatctaggaa agg gatcttc tagtttctgt gttgtttaga 3900 ctcaaagaat cacaaatttg tcagtaacat gtagttcxttt agttataz~tt 3950 cagagtgtac agaatggtaa aaattccaat cagtcaaaag aggtcaatqa 4000 attaaaaggc ttgcaacttt ttc:aaaaaaa aaaaaaaaaa 4040 <210> 459 <211> 747 <212> PRT
<213> Homo Sapiens <400> 459 Met Gly Va1 Trp Leu Asn I,ys Asp Asp Tyr I1e Arg Asp Leu Lys Arg Iie Ile Leu Cys Phe lieu I1e Val Tyr Met Ala Ile Leu Val Gly Thr Asp Gln Asp Phe '~'yr Ser Leu Leu Gly Val Ser Lys Thr Ala Ser Ser Arg Glu Ile flrg Gln A7.a Phe Lys Lys Leu Ala Leu Lys Leu His Pro Asp Lys Asn Pro Asn Asn Pro Asn Ala His Gly Asp Phe Leu Lys lle Asn Arg Ala Tyr Glu Val Leu Lys Asp Glu Asp Leu Arg Lys Lys Tyr Asp Lys Tyr Gly Glu Lys Gly Leu Glu Asp Asn Gln Gly Gly Gln 'I'yr Glu Ser Trp Asn Tyr Tyr Arg Tyr 1i0 115 120 Asp Fhe Gly Ile Tyr Asp Asp Asp I?ro Glu Ile I1e Thr Leu Glu Arg Arg Glu Phe Asp Ala F:la Vai Asn Ser Gly Glu Leu Trp Phe Val Asn Phe Tyr Ser Pro Gly Cys Ser His C ys His Asp Leu Ala Pro Thr Trp Arg Asp Phe A.La Lys Glu Val Asp G.ly Leu Leu Arg Ile Gly Ala Val Asn Cys Gly Asp Ash: Arg Met Leu Cys Arg Met Lys Gly Val. Asn Ser 'lyr Fro Ser Leu Phe ILe Phe Arg Ser Gly Met Ala Pro Val Lys T yr His G.iy Asp Arg Ser l:ys Glu Ser Leu Val Ser Phe Ala Met Gln His Va;l Arq_ Ser Thr Val Thr Glu Leu 2~;0 2 35 290 Trp Thr Gly Asn Phe Vai Asn Star Ile G~~.n Thr A1a Phe Ala Ala 295 2':0 255 Gly Ile Gly Trp Leu Ile Thr Pt:e Cys Seer Lys Gly G.l.y Asp Cys 260 2f~~> 270 Leu Thr Ser Gln Thr Arg Leu Arg Leu Ser Gly Met Leu Phe Leu Asn Ser Leu Asp Ala Lys i~lu Ile Tyi: Le:u Glu Val Iie Hi.s Asn Leu Pro Asp Phe Glu Leu ~eu Ser Ala A:~n Tlnr Leu Glu Asp Arg Leu Ala His His Arg Trp heu Le~u Phe Phe His Phe Gly Lys Asn Glu Asn Ser Asn Asp Fro (~lu Leu Lys Lys Leu Lys Thr Leu Leu Lys Asn Asp His Ile Gln '~~al Gly Arr7 Phe Asp ('ys Ser Ser Ala 350 3'~_'~ 360 Fro Asp Ile Cys Ser Asn Leu Tyr Val Phe Gln Fro Ser Leu Ala Val Phe Lys Gly Gln Gly Thr Lys Glu Tyr Glu Ile His His Gly 380 3~5 390 Lys Lys Ile Leu Tyr Asp '_1e Leu Ala Phe Ala Lys Glu Ser Val Asn Ser His Val Tl-:r Thr Leu Gly Pro Gln Asn Fhe Pro Ala Asn 910 41'_. 420 Asp Lys Glu F'r'o Trp Leu Va~ Asp Phe Phe Ala F'ro Trp Cys Pro Fro Cys Arg Ala Leu Leu Pro Glu Leu Arg Arg Ala Ser Asn Leu Leu Tyr Gly G1n Leu Lys :'he Gly Thr Leu Asp Cys Thr Val His Glu Gly Leu Cys Asn Met Tyr Asn Ile Gln Ala Tyr Pro Thr Thr Val Val Phe Asn Gin Ser Asn Ile I3is Glu Tyr Glu Gly His His Ser Aia Glu Gln Ile Leu Glu Phe Iie Glu Asp Leu Met Asn Pro Ser Val Val Ser Leu Thr Pro Thr Thr Phe Asn Glu Leu Val Thr Gln Arg Lys His Asn Glu Val Twp Met Val Asp Phe Tyr Ser Pro 5,55 54O
Trp Cys His Pro Cys Gln Val Le~u Met Fro Glu Trp Lys Arg Met Ala Arg Thr Leu Thr Gly Leu Ile Asn V<'il Gly Ser Ile Asp Cys Gln Gln Tyr His Ser Phe Cys Ana Gln G7u Asn Val Gln Arg Tyr Pro Glu I1e Arg Phe Phe Pro Pro Lys Ser Asn Lys A1a Tyr Gln Tyr His Ser Tyr Asn Gly Trp Asn Arg Asp Ala Tyr Ser Leu Arg Ile Trp Gly Leu G'ly Phe Leu Prc ~~ln Val Ser Thr Asp Leu Thr Pro Gln Thr Phe Ser Glu Lys Val Leu Gln Gly Lys Asn His Trp Val ile Asp Phe Tyr Ala Pro Trp Cys Gly Pro Cys Gln Asn Phe Ala Pro Glu Ph a Glu Leu :i.eu A~a Arg Met Ile Lys Gly Lys Val Lys Ala Gly Lys Val Asp c:ys Gin Ala Tyr Ala Gln Thr Cys Gln Lys Ala Gly I1e Arg Ala 'f'yr Pro 'fhr Val Lys Phe Tyr Phe Tyr Glu Arg Ala Lys Arg Asn fhe Gln G1~n Glu Gi.n Ile Asn Thr Arg Asp Ala Lys Aia Ile Ala Ala Leu Ile Ser Glu Lys Leu Giu Thr Leu Arg Asn Gln Gly hys Arg Asn hy; Asp Gl.u Leu <210> 460 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <900> 460 actccccagg ctgttcacac tgc:c 29 <210> 961 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1.-29 <223> Artificial Sequence <400> 461 gatcagccag ccaataccag cagc 24 <210> 462 <211> 50 <212> DNF, <213> Artificial <220>
<221> Artificial Sequence <222> 1-50 <223> Artificial Sequence <900> 962 gtggtgatga tagaatgctt tgccgaatga aaggagtcaa cagctatccc 50 <210> 963 <211> 1818 <212> DNA
<213> Homo sapiens <900> 463 agacagtacc tcctccctag gactacac:aa ggact:gaacc agaaggaaga 50 ggacagagca aagccatgaa catcatccta gaaatccttc tgcttctgat 100 caccatcatc tactcctact: tggagtcc;tt ggtg<3agttt ttcattcctc 150 agaggagaaa atctgtggct ggggagattg ttctcattac tggagctggg 200 catggaatag gcaggcagac tacttatgaa tttgcaaaac gacagagcat 250 attggttctg tgggatatta ataagcgcgg tgtggaggaa actgcagc,tg 300 agtgccgaaa actaggcgtc actgcgcotg cgtatgtggt agactgcagc 350 aacagagaag agatctatcg ctcactaaat caggtqaaga aagaagtggg 400 tgatgtaaca atcgtggtga ataatgctgg gacaqtatat ccaaccgatc 950 ttctcagcac caaggatgaa gacla-tacca agacatttga ggtcaacatc 500 ctaggacatt tttggatcac: aaaagcac:tt cttcc:atcga tgatggagag 550 aaatcatggc cacatcgtca caqtggcttc agtgtqcggc cacgaaggga 600 ttccttacct catcccatat: tgttccagca aatttgccgc tgttggcttt 650 cacagaggtc tgacatcag<c acttc~agccc ttgggaaaaa ctggtatcaa 700 aacctcatgt ctctgcccag ttrttgtc;aa tactgggttc accaaaaatc 750 caagcacaag attatggcct: gtattggaga c~agatgaagt cgtaagaagt B00 ctgatagatg gaatacttac caataagaaa atgatt.tttg ttccatcgta 850 tatcaatatc tttctgagac tacagaagtt tc:ttc:ctgaa cgcgcctcaq 900 30'>

cgattttaaa tcgtatgcag aatattc<iat tt gaagcagt ggttggccac 950 aaaatcaaaa tgaaatgaat aastaagc_-tc cagccagaga tgtatgcatg 1000 ataatgatat gaatagtttc gaatcaatgc tgcaaaqctt tatt~tca~~at 1056 tttttcagtc ctgataatat taaaaacattt ggtttgqcac tagcagcagt 1100 caaacgaaca agattaatta ccr_gtcttcc tgtttctcaa gaatatttac 1150 gtagtttttc ataggtctgt ttttcctt_t.c atgcctctta aaaacttctg 1200 tgcttacata aacatactta aaaggtttt.c tttaagatat tttatttttc 1250 catttaaagg tggacaaaag ctacctccct aaaagtaaat acaaagagaa 1300 cttatttaca cagggaagat ttaagactgt tcaagtagca ttccaatcta 1350 tagccatgcc acagaatatc aacaagaaca cagaatcaagt gcac:agctaa 1900 gagatcaagt ttcagcaggc agctttatct caacctggac atattttaag 1450 attcagcatt tgaaagattt cc~~tagcctc ttcct:ttttc attagcccaa 1500 aacggtgcaa ctctattctg gactttatta cttgattctg tcttctgtat 1550 aactctgaag tccaccaaaa gtggacc<.:tc t.atatttcct ccctttttat 1600 agtcttataa gatacattat gaaaggtc.~ac cgactct:att ttaaatctc;a 1650 gaattttaag ttctagcccc atg ataauct ttttctttgt aatttatgct 1700 ttcatatatc cttggtccca gagatgttta gacaatttta ggctcaaaaa 1750 ttaaagctaa cacaggaaaa ggaactgtac tggctattac ataagaaaca 1800 atggacccaa gagaagaa 1818 <210> 964 <211> 300 <212> PRT
<213> Homo Sapiens <900> 964 Met Asn Ile Ile Leu Glu 1e Leu Leu LEU Leu Ile Thr Ile Ile Tyr Ser Tyr Leu Glu Ser ;~eu Val Lys Phe Phe Ile Pro Gln Arg Arg Lys Ser Val A7.a Gly ;slu I'_e Va'1 Leu Ile T'hr Gly Ala Gly His Gly Ile Gly Arg Gln Thr TY:r 'I'yr Glu Pine P.la Lys Arg Gln 50 ~5 60 Ser Ile Leu Val Leu Trp Asp I1e Asn Lys Arq_ Gly Val Glu Glu Thr Ala Al.a Glu Cys Arg Lys Leu Giy Val Thr Al.a His Ala Tyr Val Val Asp Cys Ser Asn Arg Glu Glu Ile 'I'yr Arg Ser Leu Asn Gln Val Lys Lys Glu Val Gly Asp Val Thr I1e Va1 Val Asn Asn Ala Gly Thr Val Tyr Pro Ala Asp L~eu Leu Ser Thr Lys Asp Glu Glu Ile Thr Lys Thr Phe Glu Val .Ilsn Ile Leu Gly Hi.s Phe Trp Ile Thr Lys Ala Leu Leu Prc> Ser Met Met Glu Arg Asn His Gly His I=le Val Thr Val Ala Ser Val Cys Gly His Glu Gly Ile Pro 170 1~5 180 Tyr Leu Ile Pro Tyr Cys Ser SE~r Lys Phe Ala Ala Val Gly Phe His Arg Gly Leu Thr Ser i~lu LE:u Gln Ala Leu Gly Lys Thr Gly Ile Lys Thr Ser CyS heu Cys Pro Val Phe Val. Asn Thr Gly Phe Thr Lys Asn Pro Ser Thr llrg Leu Trp Pro Val Leu Glu Thr Asp 230 2~~5 290 G1u Val Val Arg Ser Leu 7.1e A~-p Giy Ile Leu Thr Asn Lys Lys Met Ile Phe Va1 Pro Ser Tyr Ile Asn Ile Phe Leu Arg Leu G1n 260 2E~5 270 Lys Phe Leu Pro Glu Arg Ala Ser Aia Ile Leu Asn Arg Met G1n 275 2~0 285 Asn Ile Gln Phe Glu Ala Val Val Gly His Lys Ile Lys Met Lys <210> 465 <211> 159 <212> DNA
<213> Homo Sapiens <900> 965 cggcggcggc. tgcgggcgcg agqtgagqgg cqcgaqgtga ggggcgcgag 50 gttcccagca ggatgccccg gctctgcagg aagctgaagt gagaggc<:cg 100 gagagggccc agcccgcccg ggqc<iggatg a<:caaggccc ggctgttc:cg 150 gctgtggctg gtgctggggt cggt<lttc:at gatcct:gctg atcatcgtgt 200 actgggacag cgcaggcgcc gcgcacttct ac:ttgcacac gtccttctct 25C
aggccgcaca cggggccgcc gctgcccacg cccgggccgg acagggacag 300 ggagctcacg gccgactccg atgtcgacga gtttctggac aagtttctca 350 gtgctggcgt gaagcagagc gaccttccca gaaaggagac ggagcagccg 900 30l cctgcgccgg ggagcatgga qgagagc~tg agag<~ctacg actqgtcccc 950 gcgcgacgcc cggcgcagcc cagaccaqgg ccggcaqcag gcggagcgqa 500 ggagcgtgct gcggggcttc tgcgccaact ccagcctggc cttccccacc 550 aaggagcgcg cattcgacga catccccnac tcggagcaga gcc~jcctgat 600 cgtggacgac cggcacgggg ccatctactg ctacgtc,Iccc aaggtggcct 650 gcaccaactg gaagcgcgtg atgatcgtgc tgagcgqaag cctqctgcac 700 cgcggtgcgc cctaccgcga cccgctg<:gc atcccgcgcg agcacgtgca 750 caacgccagc gcgcacc:tga ccttcaae:aa gttct=gqcgc cgctacggga 800 agctctcccg ccacctcatg aaggtcaugc tcaagaagta cac<:aagttc 850 ctcttcgtgc gcgacccctt cgtgcgcctg atctccgcct tccgcagcaa 900 gttcgagctg gagaacgagg ag~tctaccg ~;aagt:tcgcc gtgc:ccatgc 950 tgcggctgta cgccaaccar_ accagcctgc ccgcctcggc gcgcgaggcc 1000 ttccgcgctg gcctcaaggt gtccttcqcc aacttcatcc agtacctgct 1050 ggacccgcac acggagaagc tggcgccctt caacgaqcac tggc:ggcagg 1100 tgtaccgcct ctgccacccg tgc cagatcg actacgactt cqtggggaag 1150 ctggagactc tggacgagga cgccgcg<:ag ctgct_gcagc tactccaggt 1200 ggaccggcag ctccqcttcc ccccgag<:ta ccggaacagg accgccagca 1250 gctgggagga qgactggttc gcc;aagatcc ccctqqc:ctg gaggcagcaq 1300 ctgtataaac tctacgaggc cgactttqtt c:tcttcggct accccaagcc 1350 cgaaaacctc: ctccgagact gaaagctt tc qcgt.t:gc:ttt ttctcgcgtq 1900 cctggaacct qacgcacgcg cactccacatt tttttatgac ctacgatttt 1950 gcaatctggg cttcttgttc actccactgc ctctatccat tgagtactgt 1500 atcgatattg ttttttaaqa ttaatatatt tcag<ttattt aatacga 1547 <210> 46E
<211> 919 ~212> PRT
<213> Homo sapiens <900> 46E
Met. Thr Lys Ala Arg Leu Phe Arg L~eu Trp Leu Val Leu G1y Ser Val Phe Met Ile Leu Leu I1e Ile Val Tyr Trp Asp Ser Ala Gly 20 a.5 30 Ala Ala His Phe Tyr Leu His Thr Ser Phe Ser Arg Pro His Thr Gly Pro Pro Leu Pro Thr Pro Gly Pro Asp Arg Asp Arg Glu Leu 30f Thr Ala Asp Ser Asp Val lisp Glu Phe Leu Asp Lys Phe Leu Ser 65 ~0 75 Ala Gly Val Lys Gln Ser Asp Leu Fro Arg Lys Glu Thr Glu G1n Pro Pro Ala Pro Gly Ser Met Glu Glu Ser Val Arq Gly Tyr Asp Trp Ser Prc Arg Asp Ala Arch Arg Ser Pro Asp Gln Gly Arg Gln Gln Ala Glu Arg Arg Ser Va.i Leu Arq Gly Phe Cys Aia Asn Ser 125 1~~0 135 Ser Leu Ala Phe Pro Thr lays Glu Arq Ala Phe Asp Asp Ile Pro Asn Ser Glu Leu Ser His Leu Ile Val A~;p Asp Arg His Gly Ala Ile Tyr Cys Tyr Val Pro Lys Va.l Ala Cys Thr Asn Trp Lys Arg Val Met Ile Val Leu Ser (~ly Ser Leu Leu His Arg Gly Ala Pro Tyr Arg Asp Pro Leu Arg Cle Pro Arg Glu His Val His Asn Ala Ser Ala His Leu Thr Phe lisp Lys Fhe Trp Arg Arg Tyr Gly Lys 2i5 220 225 Leu Ser Arg His Leu Met lays Val Lys Leu Lys Lys Tyr Thr Lys 230 23.5 240 Phe Leu Phe Val Arg Asp Pro Phe Val Arq Lcu Ile Ser Al.a Phe Arg Ser Lys Phe Glu Leu Glu Asn G:lu Glu Phe Tyr Arg Lys Phe Ala Val Pro Met Leu Arg lieu Tyr Ala Ann His Thr Ser Leu Pro 2'75 280 285 Ala Ser Ala Arg Glu Ala F'he Arg Ala Gly Leu Lys Val Ser Phe Ala Asn Phe Ile Gln Tyr Leu Le-a Asp Pro His Thr Glu Lys Leu Ala Pro Phe Asn Glu His Trp Arg Gln Val Tyr Arg Leu Cys His Pro Cys Gln Ile Asp Tyr Asp PY,e Vai Gly Lys Leu Glu Thr Leu Asp Glu Asp Ala Ala Gln Leu Leu Gln Leu Leu Gln Val Asp Arg Gln Leu Arg Phe Pro Pro Ser Tyr Arg Asn Arg Thr Ala Ser Ser Trp Glu Asp Trp lle Pro Ala Trp Gln Glu E'he Leu Arg Ala Lys Gln Leu Lys Leu Asp Phe Leu Phe Tyr Tyr 'I'yr Val Gly c~lu Aia Pro Lys Glu Asn Asp Pro Leu :~en Arg <210>

<211>

~212>
DNA

<213> apiens Homo S

<400>

tcgggccagaattcggcacgaggcggcacgagggcgacggcctcacgggg50 ctttggaggtgaaagaggcccagagtagagagagagagagaccgacgtac100 acgggatggctacgggaacgcgc:tatgccgggaaggtggtggtcgtgacc150 gggggcgggcgcggcatcggagctgggatcgtgcgcgccttcgtgaacag200 cggggcccgagtggttatctgccXacaaggatgagtctgggggccgggccc250 tggagcaggagctccctggagct.gtcttcatcctctgtgatgtgactcag300 gaagatgatgtgaagaccctggtttctgagaccatccgccgatttgg<:cg350 cctggattgtgt'tgtcaacaacgctggccaccacccacccccacagaggc400 ctgaggagacctctgcccagggattccgccagctgctggagctgaaccta450 ctggggacgtacaccttgaccaagctcgccct:cccctacctgcggaagag500 tcaagggaatgtcatcaacatct.ccagc:ctggtgggggcaatcggccagg550 cccaggcagttccctatgtggccaccaagggggcagtaacagccatgacc600 aaagctttggccctggatgaaagtccatatggtgtccgagtcaactgtat650 ctccccaggaaacatctggacccvcgctgtgggaggagctggcagccttaa700 tgccagaccctagggccacaat<:cgagagggc<xtgctggcccagccactg750 ggccgcatgggccagcccgctgaggtcggggctgcggcagtgttcctggc800 ctccgaagccaacttctgcacgggcattgaactgctcgtgacggggggtg850 cagagctggggtacgggtgcaaggccaatcggagcacccccgtggacgcc900 cccgatatcccttcctgatttctctcatttca acttggggcccccttc:ct950 aggactctcccaccccaaactccaacctgtatcagatgcagcccccaagc1000 ccttagactctaagcccagt-tagcaaggtgccgggtcaccctgcaggttc1050 ccataaaaacgatttgcagcc X071 <210>

<211>

<212>
PRT

<213> Homo Sapiens <900>468 Met A1aThrG1yThrArg'"yrAlaGly LysValValValValThr Gly GlyGlyArgGlyIleGlyA1aGly IleValArgAl.aPheVal 20 c5 30 Asn SerGlyA1aArgValValIleCys AspLysAspGluSerGly Gly ArgAl.aLeuGluGlnGluLeuPro GlyAlaValPheIleLeu 50 5' 60 Cys AspValThrGlnGluAspAsp'JalLysThrLeuValSerGl.u Thr IleArgArgPheGlyF~rgLeuAsp CysValValAsnAsnAla Gly HisHisProProProGlnArgPro GluGluThrSerAlaGln Gly PheArgGlnLeuLeu!sluLe:uAsn LeuLeuGlyThrTyrThr Leu ThrLysLeuAlaLeuPro'IyrLeu ArgLysSerGlnGlyAsn Val IleAsnIleSerSerheuValGly AlaIleGlyGinAlaGln Ala ValProTyrValAlaThrLysGly AlaValThrAlaMetThr Lys AlaLeuAlaLeuAsp~'~luSerPro TyrGlyValArgValAsn 1'70 1 180 i5 Cys IleSerProGlyAsnIleTrpThr ProLeuTrpG1uGluLeu Ala AlaLeuMetProAspProArgAla ThrIleArgGluGlyMet 200 2_05 210 Leu AlaGlnProLeuGlyArgMEtGly GlnProAlaGluValGly Ala AlaA1aValPheheuAlaSerG.luAlaAsnPheCysThrGly j5 Ile GluLeuLeuVal.Thrc~l.yGlyAla GluLeuGlyTyrGlyCys Lys AlaSerArgSerThrProValAsp AlaProAspIleFroSer <210>

<211>

<212>
DNA

<213> o ns Hom sapie <900>

31..

aggcgggcag cagctgcagg ctgacctt:gc agcttgqcgg aatggactgg 50 cc:tcacaacc tgctgtttct tcttaccatt tccat_cttcc tggggctggg 100 ccagcccagg agccccaaaa gcaagaggaa ggggcaaggg cggcctgggc 150 ccctggcccc tggccctcac caggtgc~,ac tgga<_~ctggt gtcacggatg 200 aaaccgtatg cccgcatgga ggagtat<xag aggaacatcg aggagatggt 250 ggcccagctg aggaacagct cagagctcrgc c.cagagaaag tgtgaggtca 300 acttgcagct gtggatgtcc aac:aagactga gcctgtctcc ctggggctac 350 agcatcaacc acgaccccag ccqtatcccc gtggacctgc cggaggcacg 900 gtgcctgtgt ctgggctgtg tgaacccctt caccatgcag gaggaccgca 950 gcatggtgag cgtgccggtg ttcagccagg t.tcctgtgcg ccgccgcctc 500 tgcccgccac cgccccgcac agggcctt.gc cgccagcgcg cagtcatgga 550 gaccatcgct gtgggctgca cctgcatctt ctgaatcacc tggcccagaa 600 gccaggccag cagcccgaga ccatcctc~ct tgcacctttg tgccaagaaa 650 ggcctatgaa aagtaaacac tgacttttga aagcaag 68'7 <210> 970 <211> 180 <212> PRT
<213> Homo sapiens <900> 970 Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys .'~er Lys Arg Lys Gly Gln Gly Arg Pro Gly Pro LF~u Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu 50 ';5 60 Glu Tyr G1u Arg Asn Ile Glu Giu Met Val A1a Gln Leu Arg Asn Ser Ser Glu Leu Ala Gln Arg Ls;~s Cys Glu Val Asn Leu Gln Leu 80 ~ 85 90 Trp Met Ser Asn Lys Arg Ser Leu Ser Po Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu Pro G1u Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Fro Phe Thr Met Gln Glu Asp 125 1:30 135 Arg Ser Met Val Ser Val E'ro V<~l Phe Ser Gln Val Pro Val Arg 31:' Arg Arg Leu Cys Pro Pro ,'re Pro Arg Thr Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ana Val Gly Cys Thr Cys Ile Phe 170 1?5 180 <210> 471 <211> 2368 <212> DNA
<213> Homo Sapiens <400> 471 gcgccgccag gcgtaggcgg ggtggccott gcgtctcccg cttccttgaa 50 aaacccggcg ggcgagcgag gctgcggcc:c ggccc;ctgc:c cttc:cccaca 100 ctccccgccg agaagcctcg ctcggcgc.cc aacatggcgg gtgggcgctg 150 cggcccgcag ctaacggcgc tcctggcc:gc ctgg<itcgcg gctgtggcgg 200 cgacggcagg ccccgaggag gcc:gcgct gc cgccggagca gagc:cgggtc 250 cagcccatga ccgcctccaa ctggacgc:tg gtgatggagg gcgagtggat 300 gctgaaattt tacgccccat~ ggtgtcca.tc <:tgccagcag actgattcag 350 aatgggaggc ttttgcaaag aatggtga:aa tacttcagat cagtgtgggg 400 aaggtagatg tcattcaaga accaggtttg adtggccgct tctttgtcac 950 cactctccca gcattttttc atgcaaac~ga tggg<~tattc c:gccgttatc 500 gtggcccagg aatcttcgaa gacctgcaga attatatctt agagaagaaa 550 tggcaatcag tcgagcctct gactggctgg aaatccccag cttctctaac 600 gatgtctgga atggctggtc tttttagcat ctctggcaag atat.ggcatc 650 ttcacaacta tttcacagtg actcttgoaa t:tcctgcttg gtgttcttat 700 gtgtttttcg tcatagccac cttggttttt ggccttttta tgggtctgqt 750 cttggtggta at-atc:agaat gtttctat gt gccac:tt:cca aggcatttat 800 ctgagcgttc tgagcagaat cggagatcag aggactgctca tagagctgaa 850 cagttgcagg atgcggagga ggaaaaaaat gattc:aaatg aagaagaaaa 900 caaagacagc cttgtagatg atgaagaaga gaaagaagat cttggcgatg 950 aggatgaagc agaggaagaa gaggaggagg ~acaacat.ggc tgctggtgtg 1000 gatgaggaga gaagtgaggc caatgatcag gggcccccag gagaggacgg 1050 tgtgacccgg gaggaagtag aga:ctgac;ca ggctgaagaa ggcatotctg 1100 agcaaccctg cccagctgac acagaggtgg tggaagactc cttgaggc:ag 1150 cgtaaaagtc agcatgctga caagggactg tagatttaat gatgcgtttt 1200 caagaataca caccaaaaca atatgtc~gc t=tccc:tttgg cctgcagttt 1250 gtaccaaatc cttaattttt cctgaatqag caagc;ttctc ttaaaagatg 1300 ctctctagtc atttggtctc atggcagtaa gcctc:atgta tactaaggag 1350 agtcttccag gtgtgacaat caggatatag aaaaacaaac gtagtgttgc 1400 gatctgtttg gagactggga tgggaacaag ttcatttact taggggtcag 1450 agagtctcga ccagaggagq ccaittcccag tcctaatcag caccttccag 1500 agacaaggct gcaggccctg tgaaatgaoa qccaagcagg agccttggct 1550 cctgagcatc cccaaagtgt aacgtagaag ccttqcatcc ttttcttgtg 1600 taaagtattt atttttgtca aattgcac~ga aacatcaggc accacagtgc 1650 atgaaaaatc tttcacagct agaaattaaa agggccttgg gtatagagag 1700 cagctcagaa gtcatcccag ccctctgaat ctcctgtgct atgttttatt 1750 tcttaccttt aatttttcca gcatttccac catgggcatt caggctctcc 1800 acactcttca ctattatct:: ttg gtcagag gactc:caata acagccaggt 1850 ttacatgaac tgtgtttgtt cat:tctg~cc taagc~ggttt agataatcaq 1900 taaccataac ccctgaagct gtgactgcca aacatctcaa atgaaatgtt 1950 gtggccatca gagactcaaa aggaagtaag gattttacaa gacagattaa 2000 aaaaaaattg ttttgtccaa aat:atagttg ttgttgattt ttttttaagt 2050 tttctaagca atatttttca agcvc<~ga«gt cctctaagtc ttgccagtac 2100 aaggtagtct tgtgaagaaa agtt<Iaatac tgttttgttt tcatctcaag 2150 gggttccctg ggtcttgaac tactttaata ataacaaaaa aaccacttct 2200 gattttcctt cagtgatgtq cttttg_qtga aagaattaat gaactccagt 2250 acctgaaagt gaaagatttg attttgtttc catcttctgt aatcttccaa 2300 agaattatat ctttgtaaat ctcvtcaatac tcaatctact gtaagtaccc 2350 agggaggcta atttcttt 2368 <210> 972 <211> 349 <212> PRT
<213> Homo sapiens <400> 972 Met Ala Gly Gly Arg Cys Gly Pro Gln Leu Thr Ala Leu Leu Ala Ala Trp Ile Ala Ala Vai Ala Ala Thr Ala Gly Pro Glu Glu Ala Ala Leu Pro Pro Glu Gln ,e= Arq_ Va1 Gln Pro Met Thr Ala Ser Asn Trp Thr Leu Val Met Glu G7y Glu Trp Met Leu Lys Phe Tyr Ala Pro Trp Cys Pro Ser (:ys Gln Gln Thr Asp Ser Glu Trp Glu 65 i'0 75 Ala Phe Ala Lys Asn Gly Glu Ile Leu Gln Ile Ser Va1 Gly Lys 80 E'5 90 Val Asp Val Il.e Gin Glu 'r'ro Giy Leu Se-r Gly Arg Phe Fhe Val 95 lCiO 105 Thr Thr Leu Pro Ala Phe I'he Hps Ala Lys Asp G1y Iie Phe Arg 110 1l 5 120 Arg Tyr Arg Gly Pro Gly Ile Phe Glu Asp Leu Gln Asn Tyr Ile Leu Glu Lys Lys Trp Gln Ser Val. G.lu Pro Leu Thr Gly Trp Lys Ser Pro Ala Ser Leu Thr Met Ser Gly Met Ala Gly Leu Phe Ser Ile Ser Gly Lys Iie Trp His Leu His Asn Tyr Fhe Thr Val Thr 1'70 175 180 Leu Gly Iie Pro Ala Trp C;y.s Ser Tyr Val Phe Phe Val Ile Ala Thr Leu Val Phe Gly Leu Phe ME-'t Gly Leu Val Leu Val Val Ile Ser Glu Cys Phe Tyr Val Pro Leu Pro Arg His Leu Ser Glu Arg 215 2~:0 225 Ser Glu Gln Asn Arg Flrg Ser Giu Glu Ala His Arg Ala Glu Gln 230 23 _'. 290 Leu Gln Asp Ala Glu Glu Glu Lys Asp Asp Ser Asn G1u Glu Glu Asn Lys Asp Ser Leu Val lisp Asp Glu Glu Glu Lys Glu Asp Leu Gly Asp Glu Asp Glu Ala Glu Glu G:iu Glu Glu Glu Asp Asn Leu 2'75 280 285 Ala A.La G1y Val Asp C~lu Glu Arg Ser Glu Ala Asn Asp Gln G1y Pro Pro Gly G1u Asp Gly Val Tt,r Arg Glu Glu Val Glu Pro Glu Glu Ala Glu Glu Gly I1e :3er Glu Gln Pro Cys Pro Ala Asp Thr 320 3a:5 330 Glu Val Val Glu Asp Ser Leu Arg Gln Arg Lys Ser Gl.n His Ala 335 3~0 395 Asp Lys Gly Leu <210> 973 <211> 24 31 '?

<212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-24 <:223> Artificial Sequence <900> 973 gtccagccca tgaccgcctc caac 24 <210> 479 <211> 29 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <900> 474 ctctcctcat ccacaccagc agcc 29 <210> 475 <211> 44 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-49 <:223> Artificial Sequence <900> 475 gtggatgctg aaattttacg ccccatggtg tccatcctgc cage 99 <210> 476 <211> 2978 <212> DNA
<273> Homo Sapiens <900> 476 atctggttga actacttaag ctt:aatttgt taaactccgg taagtaccta 50 gcccacatga tttgactcag agatt:ctctt rtgtccacag acagtcatct 100 caggggcaga aagaaaagag ct:ccaaatg ctatatctat tcaggggc:tc 150 tcaagaacaa tggaatatca tc<:tgattta gaaaatttgg atgaagatgg 200 atatactcaa ttacacttcg actci=caaag caataccagg atagctgttg 250 tttcagagaa aggatcgtgt get:gcatctc ctccttggcg cctcattgct 300 gtaattttgg gaatcctatg ctt:ggtaata ctggtgatag ctgtggtcct 350 gggtaccatg ggggttcttt ccagcccttg tcctcctaat tggattatat 900 atgagaagaa ctgtt:atcta ttc:adcatgt cactaaattc ctgggatgga 950 agtaaaagac aatgctggca actgggctct aatctcctaa agatagac:ag 500 31 E.

ctcaaatgaa ttgggattt<i tagtaaaaca agtgt.cttcc caacctgata 550 attcattttg gataggcctt tct:cggcc:cc agactgaggt accatggctc 600 tgggaggatg gatcaacatt ctcvttctaac ttatttcaga tcacraaccac 650 agctacccaa gaaaacccat ctcca aattg tgtatggatt cacgtgtcag 700 tcatttatga ccaactgtgt agtgtgcc:ct catatagtat ttgtgagaag 750 aagttttcaa tgtaagagqa agggtggaga aggagaqaga aatatgtgaq 800 gtagtaagga ggacagaaaa cagaacagaa aagagtaaca gctgaggtca 850 agataaatgc agaaaatgtt:- tagagagctt ggccaactgt aat<:ttaacc 900 aagaaattga agggaqaggc: tgt:gatttct gtatttqtcg acctacaggt 950 aggctagtat tatttttcta gttagtarat cc ctagacat ggaatcaggg 1000 cagccaagct tgagttttta ttttttattt atttattttt ttgagatagg 1050 gtctcacttt gttacccagg ctqgagtcrca gtgg<:acaat ctcgactcac 1100 tgcagctatc tctcgcctca gcccctcaag tagct:gggac tacaggtgca 1150 tgccaccatg ccaggctaat ttttggtatt ttttqtagag actgggtttt 1200 gccatgttga ccaagctggt ct~~taactcc tgggcttaag tgatctgccc 1250 gccttggcct cccaaagtgc tgqgattaca gatgtgagcc accacacctg 1300 gccccaagct tgaattttca ttctgccatt qactt:ggcat ttaccttggg 1350 taagccataa gcgaat<:tta at'tctg<~ct ctatcagagt tgtttcatgc 1400 tcaacaatgc cattgaagtg ca~~ggtgtgt tgcca cgatt tgaccctcaa 1950 cttctagcag tatatcagtt atqaact<aag qgtg<~aatat atttctgaat 1500 agctaaatga agaaatggga aaaaatcttc accacaatca gagcaatttt 1550 attattttca tcagtatgar_ cataattatg attar-catct tagtaaaaag 1600 caggaactcc tactttttct ttatcaatt:a aata<xctcag agagtacatc 1650 tgccatatct ctaatagaat cttttttttt ttttl-ttttt ttt<~agacag 1700 agtttcgctc ttgttgccca ggctqgaqtg caacggcacg atctcggctc 1750 accgcaacct ccgccccctg ggttcaac3ca attctcctgc ctcagcctcc 1800 caagtagc:tg qgattacagt caggcaccac cacacccggc t:aattttqta 1850 tttttttagt agagacaggg ttt.ctccatg tcggtcaggg tagtcc:cgaa 1900 ctcctgacct caagtgatct gcctgcctcg gcctc~ccaag tgctgggatt 1950 acaggcgtga gccactgcac ccagcctaga atcttgtata atatgtaatt 2000 gtagggaaac tgctctcata ggaaagtttt: ctgcttttta aatacaaaaa 2050 tacataaaaa tacataaaat ctgatgarga atata aaaaa gtaaccaacc 2100 3i7 tcattggaac aagtattaac attttggaat atgttttatt agttttgtga 2150 tgtactgttt tacaattttt acc:atttttt tcagtaatta ctgtaaaatg 2200 gtattattgg aatgaaacta tatttcctca tgtgca gatt tgtcttattt 2250 tt.ttc:atact: ttcccactgg tgc~tattt tt atttc:caatg gatatttctg 2300 tattactagg gaggcattta cagtcctcto atgttgatta atat.gtgaao 2350 agaaattgta ccaattttac t:aaattatgc agtttaaaat ggatgatttt 2400 atgttatgtg gatttcattt caataaaaaa aaactcttat caaaaaa~:aaa 2950 aaaaaaaaaa aaaaaaaaaa aaaaaaa~24?8 <210> 97?
<211> 201 <212> PRT
<213> Homo Sapiens <400> 477 Met Glu Tyr His Pro Asp Leu G1u Asn Leu Asp Glu Asp Gly Tyr Thr Gln Leu His Phe Asp Ser. G:n Ser A:n Thr Arg Ile Ala Val 20 a?5 30 Val Ser Glu Lys Gly Ser ~~ys Ala Ala Ser Pro Pro Trp Arg Leu 35 ~10 45 Ile Ala Val Ile Leu Gly Ile Leu Cys Leu Val Ile Leu Val Ile 50 _'; ~ 60 Ala Val Va.l. Leu Gly Thr Met G';y Va.1 Leu Ser Ser Pro C:ys Pro 65 ~70 75 Pro Asn Trp Ile Il.e Tyr t;lu L=Y~s Ser Cvs Tyr Leu Phe Ser Met Ser Leu Asn Ser Trp Asp Gly Sc.r Lys Arg Gln C:ys Trp Gln Leu Gl.y Ser Asn Leu Leu Lys Ile A,p Se.r SEer Asn C~lu Leu C;l.y Phe 110 l L5 120 Ile Val Lys Gln Val Ser Ser Gn Pro Asp Asn Ser Phe Trp Ile Gly Leu Ser Arg Pro Gln 'I'hr G.u Val Pro Trp Leu Trp Glu Asp Gly Ser Thr Phe Ser Ser .4sn Le-'u Phe G.i.n Ile Arg Thr Thr Ala Thr Gln Gl.u Asn Pro Ser Pro Asn Cys Val Trp Ile His Val Ser Val Ile Tyr Asp Gln Leu C'ys Ser Val P_.ro Ser Tyr Ser Ile Cys Glu Lys Lys Phe Ser Met <210> 478 <211> 27 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-27 <223> Artificial Sequence.
<900> 478 gtccacagac agtcatctca ggagcag 27 <210> 479 <211> 20 <212> DNA
<213> Artificial <:220>
<221> Artificial Sequence <222> 1-20 <223> Artificial Sequence <900> 479 acaagtgtct tcccaacctq 20 <210> 480 <211> 29 <212> DNA
~~213> Artificial <220>
<:221> Artificial Sequence <:222> 1-24 <223> Artificial Sequence <4C0> 980 atcctcccag agccatggta cct:c 2.9 <210> 981 <211> 51 <212> DNA
<213> Artificial <220>
~:221> Artificial Sequence <222> 1-51 <223> Artificial Sequence <400> 981 ccaaggatag ctgttgtttc agagaaaatga tcgtgtgctg catctcctcc 50 t 51 <210> 982 <211> 3819 <212> DNA
<213> Homo Sapiens <400> 982 ggaaggggag gagcaggcca cacaggcaca ggccggtgag ggacctgccc 50 agacctggag ggtctcgctc tgtcacac:ag gctgc~agtgc agtggtgtga 100 tcttggctca tcgtaacctc cacctccc:gg rattcaa~xtga ttctcatgcc 150 tcagcctccc gagtagctgg gattacacgt ggtg<3cttcc aagagtgact 200 ccgtcggagg aaaatgactc cc::agtcgct. gctgcagacg acactgttcc 25C
tgctgagtct gctcttcctg gtccaagc;t:g cccacggcag gggc:cacagg 30C
gaagactttc gcttctgcag cc.agcggaac cagacacaca ggagcag.cct 350 ccactacaaa cccacaccag acctgcg<:at. ctcc<jtcgag aactccgaag 400 aggccctcac agtccatgcc cctttccca:g c::agcccaccc tgcttcccga 450 tccttccctg accccagggg cctctacc:ac ttctgc~~tct actggaaccg 500 acatgctggg agattacatc tt:ctctatgg caagcgtgac t:tcttgctga 550 gtgacaaagc ctctagcctc ctctgcttcc agcaccagga ggagagcct.g 600 gctcagggcc ccccgctgtt agccacttct gtcac ctcct ggtggag::cc 650 tcagaacatc agcctgccca gtgccgccag cttcaccttc t:.ccttccaca 100 gtcctcccca cacggccgct cacaatgc:ct cggtggacat gtgcgagctc 750 aaaagggacc tccagctgct cagccagttc c,tga<3ge:atc c:ccagaaggc 800 ctcaaggagg ccctcggctd cc~~ccgcc,ag ccagcagttg cagagcctgg 850 agtcgaaact gacctctgtg agattcatgg gggacatggt gtccttcgag 900 gaggaccgga tcaacgccac ggt.gtggaag ctcc<~gccca c:agccggcct 950 ccaggacc:tg cacatccact cccggcagga ggaggagcag agcgagatca 1000 tggagtactc ggtgctgctg cctcgaa<:ac tcttccagag gacgaaaggc 1050 cggagcgggg aggctgagaa gag actcat:c ctggtggact tcagcagcca 1100 agccctgttc caggacaaga att.ccagc:ca agtcctgggt gagaaggtct 1150 tggggattgt ggtacagaac accaaagt.ag c:caacct:cac ggagcccgt:g 1200 gtgctcactt tccagcacca gct.acagc:cg aaga<itgtga ctctgcaatg 1250 tgtgttctgg gttgaagacc ccacattc~ag cagcccgggg cattggagc.a 1300 gtgctgggtg tgagaccgtc aggagag<taa cccaaac:atc c:tgcttctgc 1350 aaccacttga cctactttgc agtgctgatg gtct<~ctcgg tggaggtgga 1400 cgccgtgcac aagcactacc tgagcct~:ct ctcctacgtg ggctgtgtcg 1450 tctct.gccct ggcctgcctt gtcaccattg ccgcctacct ca gctccagg 1500 gtgcccctgc cgtgcaggag gaaacctcgg gactacacca tcaaggtgca 1550 catgaacctg ctgctggccg tcttcctcXct ggaca cgagc t:tcctgctca 1600 gcgagccggt ggccctgaca ggctctgagg ctggctgccg agccagtgcc 1650 atcttcctgc acttctccct gct.cacctgc ct:ttcctgga tgggcctc:ga 1700 ggggtacaac. ctctaccgac tcgtggtgga ggtctttgc7c acct:atgtcc 1750 ctggctacct actcaagctg agc;gc:catgg <~caggggct.t. ccccatcttt 1800 ctggtgacgc tggtggccct ggt:ggatgtg gacaactat.g gccccatcat 1850 cttggctgtg cataggactc cactagggcgt catctaccct tccatgtgct 1900 ggatccggga ctccctggtc agctacatca cc:aacctgqg cctcttcagc 1950 ctggtgtttc tgttcaacat ggc:catgca a gccaccatgg tggtgcagat 2000 cctgcggctg cgcccccaca ccc:aaaagtg gt:cacatgtg ctgacact:gc 2050 tgggcctcag cctggtcctt: ggcctgccct gggccttgat cttcttct:cc 2100 tttgcttctg gcaccttcca gct.tc~tcctc ct:ctac<:ttt. tcagcatc:at 2150 cacctccttc caaggcttcc tcatctt<at c:tggtactgg tccatgccagc 2200 tgcaggcccg gggtggcccc tcc:cctctga agagcaactc agacagcgcc 2250 aggctcccca tcagctcggg cagcacctcg tccaqcc:gca tctaggcc:tc 2300 cagcccacct gcccatgtga tgaagcagag atgcggcctc gtcgcacact 2350 gcctgtggcc cccgagccag gce:cagcccc aggccagtca gccgcagact 2900 ttggaaagcc caacgaccat ggagagatgg gccgttgcc:a tggtggacgg 2950 actcccgggc tgggcttttg aat:tggcctt ggggactact cggcactc:ac 2500 tcagctccca cgggactcag aagtgcgccg ccatqctgcc tagggtactg 2550 tccccacatc tgtcccaacc cagc~ggagg cc.tggtctct ccttacaac c 2600 cctgggccca gccctcattg ctc:~ggggcca c,~gccttggat; cttgagggtc 2650 tggcacatcc ttaatcctgt gcc:cctgcct gggac:agaaa tgtggctcca 2700 gtt.gctctgt ctctcgtggt: cac:cctg~~gg gcact.ctgca tcctctgtca 2750 ttttaacctc aggtggcacc cagggcgaat ggggc:ccagg gcagaccttc 2800 agggccagag ccctggcgga ggagagg<cc t:t_tgc:c:agga gcac:agcagc 2850 agctcgccta cctctgagcc caggcccc:ct c:cctccc:tca gccccccagt 2900 cctccctcca tcttccctgg ggttctcctc ctctcccagg qcctccttgc 2950 tccttcgttc acagctgggg gtccccgatt ccaat:gctgt. tttttgggga 3000 gtggtttcca ggagctgcct ggtgtctcct gtaaatgttt gtctactgca 3050 caagcctcgg cctgcccctg agccagg<:tc ggtaccgatg cgtgggctgg 3100 gctaggtccc tctgtccatc tgggcctttg tatgagctgc attgcccttg 3150 ctcaccctga ccaagcacac gcu.tcagagg gg ccctcagc ctctcctgaa 3200 gccctcttgt ggcaagaact gtggaccatg ccagtcccgt ctggtttcca 3250 tcccaccact ccaaggactg ag<:~ctga<ct c ctctggtga cactggccta 3300 gagcctgaca ctctcctaag aggttctctc caagccccca aatagctcca 3350 ggcgccctcg gccgcccatc atclgttaatt ct~gtc:caaca aacacacaca 3900 ggtagattgc tggcctgttg taggtggtag ggacacagat gaccgacctg 3950 gtcactcctc ctgccaacat tcagtctcxgt at_gtqaggcg t.gcgtgaagc 3500 aagaactcct ggagca acag gga c,3ggc;ag ccatc:attcc tgcctgggaa 3550 tcctggaaga cttcctgcag gagtcagcgt tcaatcttga ccttgaagat 3600 gggaaggatg ttctttttac gta ccaattc tt_ttcrtcttt tgatattaaa 3650 aagaagtaca tgttcattgt agagaatttg gaaacagtag aagagaatca 3700 agaagaaaaa taaaaatcag ctgttgtaat c;gcctagcaa aaaaaaaaaa 3750 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 3800 aaaaaaaaaa aaaaaaaaa 381' <210> 483 <211> 693 <212> PRT
<213> Homo sapiens <900> 483 Met Thr Pro Gln Ser Leu Leu Gin Thr Thr Leu Phe Leu Leu Ser Leu Leu Phe Leu Va.1 Gln (~ly Ala His G7.y Arg Gly His Arg Glu 20 a5 30 Asp Phe Arg Phe Cys Ser C~ln Axg Asn G7.n Thr His Arg Ser Ser Leu His Tyr Lys Fro Thr Pro A__p Leu Arg Ile Ser Ile Glu Asn '.~0 '_;5 60 Ser Glu Glu Ala Leu Thr 'Jal His A1a Pro Phe Pro Ala Ala His 65 ~'0 75 Pro Ala Ser Arg Ser Phe Pro A.:p Pro Aig Gly Leu Tyr His Phe Cys Leu Tyr Trp Asn Arg His Ala Gly Arg Leu His Leu Leu Tyr Gly Lys Arg Asp Phe Leu Leu Ser Asp Lys Ala Ser Ser Leu Leu 110 1_5 120 Cys Phe Gln His Gln Glu Glu S<:r L.~eu A_ a Gln C-~ly Pro Pro Leu Leu Ala Thr Ser Val Thr Ser Trp Trp Ser Pro Gln Asn Iie Ser 190 195 1.50 Leu Pro Ser Ala Ala Ser F'he Thr Phe Ser Phe His Ser Pro Pro His Thr Ala A:La His Asn Ala Ser Val Asp Met Cys Glu Leu Lys 1?0 175 180 Arg Asp Leu Gln Leu Leu Ser Gln Phe Leu Lys His Pro Gln Lys Ala Ser Arg Arg Pro Ser Ala Ala Pro Ala Ser Gln Gln Leu Gln Ser Leu Glu Ser Lys Leu Thr Ser Va.L Arg Phe Met Gly Asp Met Val Ser Phe Glu Giu Asp Arg Ile Asn Ala Thr Val Trp Lys Leu 230 ' 235 240 Gln Pro Thr Ala Gly Leu Gln Asp Leu His Ile His Ser Arg Gln Glu Glu Glu Gln Ser Glu Ile Met Glu Tyr Ser Vai Leu Leu Pro Arg Thr Leu Phe Gln Arg "'hr Lys Gly Arg Ser Gly Gl.u Ala Glu 2.75 280 285 Lys Arg Leu Leu Leu Val Asp Phe Ser Ser G1n Ala Leu Phe Gln Asp Lys Asn Ser Ser Gln Val Leu G1y Glu Lys Val Leu Gly Ile Val Val Gln Asn Thr Lys Val Ala Asn Leu Thr Glu Pro Val Val Leu Thr Phe Gln His Gln Leu Gin Pro Lys Asn Val Thr Leu Gln 3'3.'390 345 Cys Val. Phe Trp Val Glu Asp Pxo Thr Leu Ser Ser Pro Gly His Trp Ser Ser Ala Gly C:ys Glu TY,r Vai Arg Arg Glu Thr Gln Thr Ser Cys Phe Cys Asn His heu TL,r Tyr Phe Ala Val Leu Met Val Ser Ser Val G1u Val Asp Ala Val His Lys His Tyr Leu Ser Leu Leu Ser Tyr Val Gly Cys Val Val Ser A7a Leu Ala Cys Leu Val Thr Ile Ala Ala Tyr Leu c~ys Ser Arg Val Pro Leu Pro Cys Arg Arg Lys Fro Arg Asp Tyr 'I'hr Ile Lys V<~l His Met Asn Leu Leu Leu Ala Vai Phe Leu Leu Asp TY:r Ser Phe Leu Leu Ser Glu Pro Val A1a Leu '1'hr G1y :>er (~lu Ala.~ Gly Cys Arg Ala Ser Ala Ile Phe Leu His Pk:e Ser Leu Leu Thr Cys Leu Ser T:rp Met Gly Leu Glu Gly 'I'yr Asn Leu Tyr Arg Leu Val Val Glu Val Phe Gly Thr Tyr Val Pro Gly Tyr Leu heu Lys Leu Ser Ala Met. Gly Trp Gly Phe Pro Ile Phe heu Val '.Fhr Leu Val Ala Leu Val Asp Val Asp Asn Tyr Gly Pro Ile Ile L,eu Ala Va:L His Arg Thr Pro Glu Gl.y Val Iie Tyr Pro Ser Met c:."ys Trp Ile Arg Asp Ser Leu Val Ser Tyr Ile 'Ihr Asn Leu Gly heu Phe Ser Leu Val Phe Leu Phe Asn 57 '. 580 585 Met Ala Met Leu Ala Thr Met Val Val. Gln Ile Leu Arg Leu Arg Pro His Thr G:Ln Lys Trp her His Val Leu Thr Leu Leu G1y Leu Ser Leu Val Leu Gly Leu Prc- Trp Ala Leu Ile Phe Phe Ser Phe Ala Ser Gly Thr Phe Gin l.~eu Val Va.1 Leu Tyr Leu Phe Ser Ile Ile "'hr Ser Phe Gl.n Gly Phe Len Ile Phe Ile Trp Tyr Trp Ser Met Arg Leu Gln Ala Arq C~ly Gly Pro Ser Pro Leu Lys Ser Asn Ser Asp Ser Ala Arg Leu Pro Ile Ser Ser Gly Ser Thr Ser Ser Ser Arg Ile <210> 989 <:211> 516 <212> DNA
<213> Homo sapiens <220>
<221> unsure <222> 68, 70, 89, 197 <223> unknown base <400> 989 tgcctggcct gccttgtcaa ca<3tgcccact t.act<a gctt ccaggttgcc 50 ctgccttgca gaggaaancn tcgggactac accnt=caagt gcacatgaac 100 ctgctgctgg ccgtcttcct: gctggacacg agctt:cc:tgc tcagcgnagc 150 cggtggccct gacaggctct: gaagg ctggc t.gccc~agcca gtgccatctt 200 cctgcacttc tcctgctcac ctgcctttcc t.ggatgggcc tcgaggggta 250 caacctctac cgactcgtgg tggaggtott t.ggcacctat gtcc:ctggct 300 acctactcaa gctgagcgcc atgggctggg gcttc:cccat cattctggtg 350 acgctggtgg ccctggtgga tgtggacaac tatggcccca tcat.cttggc 400 tgtgcatagg actccagagg gcgtcatc:ta cccttccatg tgctggatcc 450 gggactccct ggtcagctac att:accaacc tgggc:ctctt cagcctggtg 500 tttctgttca acatgg 516 <210> 485 <211> 22 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-22 ~:223> Artificial Sequence <900> 985 ggcattggag cagtgctggg tg 22 <:210> 486 <21i> 24 <212> DNA
<:213> Artificial <220>
<2:21> Artificial Sequence <:222> 1-24 <:22 j> Artificial Sequence <900> 486 t.ggaggccta gatgc.ggctg gacg 24 <210> 487 <211> 2849 <212> DNA
<21i> Homo sapiens <220>
<221> unsure <:222> 2715 <223> unkncwn base <900> 987 cggacgcgtg ggcggacgcg tgggcggacg cgtgggcgga cgcgtgggct 50 ggttcaggtc caggttttgc tttgatc< tt ttca<3aaact. ggac~acacag 100 aagagggctc taggaaaaag ttttggatgg gattatgtgg aaactaccct 150 gcgattctct gctgccagag cag gctcggc gct.tccaccc c:agtgcagcc 200 ttcccctggc ggtggtgaaa gagactcggg agtcactgct tccaaagt~gc 250 ccgccgtgag tgagctctca ccc:c<3gtcag ccaaatgagc ctcttcgggc 300 ttctcctgct gacatctgcc ctggc~cgCCC agagacaggg gactcaggcg 350 gaatccaacc tgagtagtaa attccagttt tccaacaaca aggaacagaa 400 cggagtacaa gatcctcagc; atgagagaat tattactgtg tctactaatg 450 gaagtattca cagcccaagg ttt:cctcata cttatccaag aaatacgc~tc 500 ttggtatgga gat.tagtagc agt.agaggaa aatgtatgga tacaact.t:ac 550 gtttgatgaa agatttgggc ttgaagaccc agaagat:gac atatgcaagt 600 atgattttgt agaagttgag gaacccaatg atggaactat attagggc:gc 650 tggtgtggtt ctggtactgt accaggaaaa cagatttcta aaggaaat.ca 700 aattaggata agatttgtat ctgatgaata tt:ttc:c:t.tc.:t gaaccagggt: 750 tctgcatcca ctacaacatt: qtaatgcc:ac aattc:acaga agctgtgagt 600 ccttcagtgc tacccccttc agcy ttgcca ctggacctgc ttaataatgc 850 tataactgcc ttt.agt.acct tggaagacct t.attcgatat cttgaacc:ag 900 agagatggca gttggactta gaagatctat ataggccaac t.tggcaact.t 950 cttggcaagg cttttgt.t.tt: t:g<:~aagaaaa tccac~agtgg tggatctgaa 1000 ccttctaaca gaggaggtaa gattatac;ag ctgcacacct cgtaacttct 1050 cagtgtccat aagggaagaa ctriaagactaa ccgat.ac:cat t.ttctggc:ca 1100 ggttgtctcc tggttaaacg ctc:~tggtcagg aactqtgcct gttgtctcca 1150 caattgcaat gaatgtcaat gtgtcccaag caaagttact aaaaaatacc 1200 acgaggtcct tcagttgaga ccaaagaccg gtgtc;agggg attccacaaa 1250 tcactcaccg acgtggccct ggagcaccat gaggagtgtg actgtgtgtg 1300 cagagggagc acaggaggat: ag<:cgcat ca c;caccagcag ctct tgccca 1350 gagctgtgca gtgcagtggc tgattctatt agagaacgta tgcgttatct 1400 ccatccttaa tctcagttgt ttgcttc<sag gacctttcat cttcaggat:t 1450 tacagtgcat tctgaaagag gagacatc::aa acagaattag gagttgtgca 1500 acagctcttt tgagaggagg cctaaaggac aggagaaaag gtcttcaatc 2550 gtggaaagaa aattaaatgt tgtatta«at agat<:ac:cag ctagtttcag 1600 agttaccatg tacgtattcc actagctggg ttctgtattt. cagttctttc 1650 gatacggctt agggtaatgt cagtacagga aaaaaactgt gcaagtgagc 1700 acctgattcc gttgccttgc ttaactctaa agctccatgt cctgggccta 1750 aaatcgtata aaatctggat ttt:ttttttt ttttttgctc atattcac:at 1800 atgtaaacca gaacattcta tgt:actac:aa acctggtttt taaaaaggaa 1850 ctatgttgct atgaattaaa cttgtgtcat gctgatagga cagactgctat 1900 ttttcatatt tcttattaaa atttctgcca t:ttagaagaa gagaactaca 1950 ttcatggttt ggaagagata aacctgaaaa gaagagtggc cttatctt.ca 2000 cttt.atcgat aagtc:agttt atttgtttca tt:gtgtacat ttttatat:tc 2050 tccttttgac attataactg ttggcttttc taatcttgtt aaatatatct 2100 atttt.tacca aaggtattta atattct.ttt tt.atcacaac ttagatcaac: 2150 tatt.tttagc ttggt.aaatt tttct_aaaca caattgttat agccagagga 2200 acaaagatga tataaaatat tgt_tgctctg acaaaaatac atgtattt:ca 2250 ttctcgtatg gtgctagagt ta<~attaarc t:qcattttaa aaaactgaat 2300 tggaatagaa ttggtaagtt gcaaagactt tt:tgaaaata attaaattat 2350 catatcttcc attcctgtta ttc~gagatga aaataaaaag caacttatqa 2400 aagtagacat tcagatccag ccr~ttactaa cc:tattcctt ttttggggaa 2450 atctgagcct agctcagaaa aa<:ataaagc accttgaaaa agacttggca 2500 gcttcctgat aaagcgtgct: gtc~ctgtcaca gtaggaacac atcctatt:ta 2550 ttgtgatgtt gtggttttat: tat:cttaaac t.ctgttccat acac.ttgt:at 2600 aaatacatgg atatttttat gtacagaagt atgtctctta accagttc:ac 2650 ttattgtact ctggcaattt: aaaagaaaat cagtaaaata ttttgctt:gt 2700 aaaatgctta atatngtgcc taggttatgt ggtgactatt tgaatcaaaa 2750 atgtattgaa tcatcaaata aaagaatatg pctattttgg ggagaaaatt. 2800 aaaaaaaaaa aaaaaaaaaa aggt-taggg ataac:agggt aatgcggcc 2899 <210> 988 <211> 395 <212> PRT
<213> Homo sapiens <400> 988 Met Ser Leu Phe Gly Leu Leu Leu Leu Thr Ser Ala Leu Ala Gly 1 5 '0 15 Gln Arg Gln Gly Thr Gln Ala G7u Ser A:>n Leu Ser Ser Lys Phe Gln Phe Ser Ser Asn Lys Glu Gln Asn Gly Val Gln Asp Pro Gln 3'_~ 90 45 His Glu Arg Ile Ile Thr 'Ja.1 SEr Thr Asn Gly Ser Ile His Ser Pro Arg Phe Pro His Thr Tyr Pro Arch Asn Thr Val Leu Val Trp 65 ~~0 75 Arg Leu 'Jal Ala Val Glu C~lu Asn Val Trp Ile Gln Leu Thr Phe Asp Glu Arg Phe Giy Leu C~lu Asp Prc~ Glu Asp Asp Ile Cys Lys Tyr Asp Phe Val Glu Val Glu Glu Pro Ser Asp G1y Thr Ile Leu Gly Arg Trp Cys Gly Ser <,1y Thr Val Pro Gly Lys Gln Ile Ser Lys Gly Asr~: Gln Ile Arg =le Arq Phe Val Ser Asp Glu Tyr Phe Pro Ser Glu Pro Gly Phe Cys Ile His Tyr Asn Ile Val Met Pro Gln Phe Thr Glu A1a Val Ser Pro Ser Val Leu Pro Pro Ser Ala Leu Pro Leu Asp Leu heu Asn Asn Ala Ile Thr Ala Phe Ser Thr Leu G1u Asp Leu Ile Arg Tyr Leu Glu Pro Glu Arg Trp Gln Leu Asp Leu Glu Asp Leu Tyr Arg Pro Tt~:r Trp Gln Leu Leu Gly Lys Ala Phe Val Phe Gly Arg l,ys SEr Arg Val Val Asp Leu Asn Leu Leu Thr Glu Glu Val Arg Leu Tyr Ser Cys Thr Pro Arg Asn Phe 245 2~~0 255 Ser Val Ser Ile Arg Glu t~lu Leu Lys Arg Thr Asp Thr Ile Phe Trp Pro Gly Cys Leu Leu ~..~al Lys Arg Cys Gly Gly Asn Cys Ala Cys Cys Leu His Asn Cys Asn Glu Cys Gln Cys Val Pro Ser Lys Val Thr Lys Lys Tyr His Glu Val Leu Gl.n Leu Arg Pro Lys Thr Gly Val Arg Gly Leu His '~ys Ser Leu Thr Asp Val Ala Leu Glu His His Glu Glu Cys Asp Cys Val Cys Arg Gly Ser Thr fly Gly <210> 989 <211> 21 ~:212> DNA
<.213> Artificial <220>
<221> Artificial Sequence <222> 1-21 <223> Artificial Sequence <400> 489 acttCtcagt gtccataagg a ~'1 <210> 490 <:211> 40 <212> DNA
<213> Artificial <220>
<.221> Artificial Seauence <222> 1-90 <.223> Artificial Sequence <400> 990 gaactaaaga gaaccgatac cattttct.gg ccaggtt.gtc 40 <210> 991 <211> 20 <212> DNA
<213> Artificial «20>
<221> Artificial Sequence <222> 1-20 <223> Artificial Sequence <400> 491 caccacagcg tttaaccagg 20 <210> 492 <211> 20 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 7.-20 <c223> Artificial Sequence ~:900> 492 acaacaggca cagttcccac 20 <210> A93 <27.1> 21 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <:222> 1-21 <223> Artificial Sequence <400> 993 ggcggaatcc aacctgagta g 21 <210> 999 <211> 20 <212> DNA
<213> Artificial <220>
32'~

<':221> Artificial Sequence <222> 1-20 c:223> Artificial Sequence ~:400> 999 gcggctatcc tcctgtgctc 20 <210> 995 <211> 3283 <212> DNA
<213> Homo Sapiens <900> 995 cccatctcaa gctgatcttg gcacctctca t.gctctgctc tcttcaacca 50 gacctctaca ttccattttg gaagaagact aaaaatggtg tttccaatgt 100 ggacactgaa gagacaaatt cttatccttt ttaac:ataat cctaatttcc 15C
aaactccttg gggctagatg gtt,tcctaaa actctgccct gtgatgtc:ac 200 tctggatgtt ccaaagaacc atgtgatcgt ggactgcaca gacaagcatt 250 tgacagaaat tcctggaggt: attcccac:ga ac:accacgaa cctcaccctc 300 accattaacc acataccaga catctcccca gcgtc:ctttc acagactgga 350 ccatctggta gagatcgatt: tc<sgatgcaa c:tgtgtacct attccactgg 900 ggtcaaaaaa caacatgtgc: atcaagaegc tgcagattaa acccagaagc 450 tttagtggac tcacttattt aaaatccc:tt t.acctggatg gaaaccagct 500 actagagata ccgcagggcc tc;~cgcctag cttacagctt ctcagccttg 550 aggccaacaa catcttttcc atcagaaaag agaatctaac agaactggcc 600 aacatagaaa tactctacct gggccaaaac t:gttattatc gaaatccttg 650 ttatgtttca tattcaatag agaaagatgc cttcctaaac ttgacaaagt 700 taaaagtgct ctccctgaaa gataacaatg tcacagccgt ccctactgtt 750 ttgccatcta ctttaacaga ac~atatc:ac t.acaacaaca tgat:.tgcaaa 800 aatccaagaa gatgatttta ataacctc:aa ccaattacaa attcttgacc 850 taagtggaaa ttgccctcgt tgttataatg ccccatt:tcc ttgtgcgccg 900 tgtaaaaata attctcccct acagatc~::ct gtaaatgctt ttgatgcgct 950 gacagaatta aaagttttac gtctacacag t.aactctctt cagc:atgtgc 1000 ccccaagatg gtttaagaac atcaacaaac tccaggaact ggatctgtcc 1050 caaaacttct tggccaaaga aattgggcat gctaaatttc t.gcattttct 1100 ccccagcctc atccaattgg atctgtcrtt caattttgaa c:ttcaggtct 1150 atcgtgcatc tatgaatcta tcacaagc:at tttctt;~act gaaaagcctg 1200 aaaattct.gc ggatcagagg atatgtcttt aaagagttga aaagctttaa 1250 cctctcgcca ttacataatc ttcaaaatct t:gaagttctt gatcttggca 1300 ctaactttat aaaaattgct aacct:cagca tgtttaaaca atttaaaaga 1350 ctgaaagtca tagatctttc agtgaataaa atatcacctt caggagattc 1400 aagtgaagtt ggcttctgct caaat:gc:cag aacttctgta gaaagttatg 1950 aaccccaggt cctggaacaa ttacattatt tcagatatga taagtatgca 1500 aggagttgca gattcaaaaa caaagaggct t.ctttcatgt ctgttaatga 1550 aagctgctac aagtatgggc agacc:ttgga tc;taagt.aaa aatagtatat 1600 tttttgtcaa gtcctctgat tttcagcatc t.ttctttcct caaatgcctg 1650 aatctgtcag gaaatctcat taqccaaact ct:taatggca gtgaatt<:ca 1700 acctttagca gagctgagat atttggactt ctccaacaac cggcttgatt 1750 tactccattc aacagcattt gaaga gcttc acaaact:gga agttctggat 1800 ataagcagta atagccatta ttttcaatca gaagcaatta ctcatatgct 1850 aaactttacc aagaacctaa age;ttctgca gaaactgatg atgaacgaca 1900 atgacatctc ttcctccacc agcaggacca tggagagtga gtctcttaga 1950 actctggaat tcagaggaaa tcacttagat gt:tttatgga gagaaggtga 2000 taacagatac ttacaattat tcaagaatct <~ctaaaatta gaggaatt:ag 2050 acatctctaa aaatt.cccta agt:ttcttgc cttctggagt ttttgatggt 2100 atgcctccaa atctaaagaa tct:ctctttg gccaaaaat.g ggctcaaatc 2150 tttcagttgg aagaaactcc agtgtctaaa gaaccaggaa actttggacc 2200 tcagccacaa ccaactqacc: acrgtccctg ac~agat:tatc caactgttcc 2250 agaagcctca agaatctgat. tcttaaga:at aatcaaatca ggagtctgac 2300 gaagtatttt. ctacaagatg ccttccar,tt gcgatat:ctg gatctcagct 2350 caaataaaat ccagatgatc: caaaagaoca gcttc:cc;aga aaatgtc~:~tc 2900 aacaatctga agatgttgct ttt.gcatcat aatcggtttc tgtgcacct.g 2450 tgatgctgtg tggtttgtct ggtg~~gtt as ccatacc4gag gtgactattc 2500 cttacctggc cacagatgtg acttgtgtgg ggccaggagc acacaagggc 2550 caaagtgtga tctccctgga tct:gtaca-~cr_ tgtgagttag atct:gacr:aa 2600 cctgattctg ttctcacttt ccatatctgt atctctcttt ctcatggtga 2650 tgatgacagc aagtc:accts tatttctggg atgtgtggta tatttaccat 2700 ttctgtaagg ccaagataaa ggggtatc:ag cgtctaatat caccagactg 2750 ttgctatgat gcttttattg tg~~atgacac t:aaagaccca gctc~tgaccg 2800 agtgggtttt ggctgagctg gtggccae:ac tggaagaccc aagagagaaa 2850 cattttaatt tatgtctcga ggaaagggac tggttaccag ggcagccagt 2900 tctggaaaac ctt.tcccaga gcGtacagct t.agcaaaaag acagtgtttg 2950 tgatgacaga caagtatgca aagactgaaa at:.t:ttaagat agcattttac 3000 ttgtcccatc agaggctcat gga.tgaaaaa gt.t:gatgt.ga ttatcttoat 3050 atttcttgag aagccctttc agaagtccaa gt:tcctccag ctccggaaaa 3100 ggctct.gtgg gagttctgtc: cttgagtggc caacaaaccc gcaagctc:ac 3150 ccatacttct ggc:agtgtct aaagaacgcc ctggccacag acaatcatgt 3200 ggcctatagt caggtgttca aggaaacg:at c;tagcccttc tttgcaaaac 3250 acaactgcct agtttaccaa ggagaggcct ggc 3283 <:210> 996 <211> 1099 <212> PRT
<.213> Homo sapiens <400> 496 Met Val Phe Pro Met Trp 7'hr Lea Lys Arg Gln Ile Leu Ile Leu Phe Asn Ile Ile Leu Ile Ser Lys Leu Leu Gly Ala Arg Trp Phe Pro Lys Thr Leu Pro Cys F.sp Val Thr Leu Asp Val Pro Lys Asn His Val Ile Val Asp Cys 'Thr Asp Lys His Leu Thr Glu Ile Pro Gly Gly Ile Pro Thr Asn Thr TY<r Asn Leu Thr Leu Thr Ile Asn His Ile Pro Asp Ile Ser Pra Ala Ser Phe His Arg Leu Asp His ao s5 90 Leu Val Glu Ile Asp Fhe Arg Cys Asn Cys Val Pro Ile Pro Leu Gly Ser Lys Asn Asn Met C'ys Ile Lys Arg Leu Gln Ile Lys Pro Arg Ser Phe Ser Gly Leu Thr Tyr Leu Lys Ser Leu Tyr Leu Asp Gly Asn Gln Leu Leu Glu lle Fro Gln Gly Leu Pro Pro Ser Leu 190 19w 150 Gln Leu Leu Ser Leu Glu Ala An Asn Ile Phe Ser Ile Arg Lys 155 1E~0 165 Glu Asn Leu Thr Glu Leu Ala Asn 11.e Glu Ile Leu Tyr Leu Gly Gln Asn Cys Tyr Tyr Arg Asn Pro Cys Tyr Val Ser Tyr Ser Ile Glu Lys Asp Ala Phe Leu I~a n Leu Thr Lys Leu Lys Val Leu Ser Leu Lys Asp Asn Asn Val Thr Ala Val Pro Thr Val Leu Pro Ser Thr Leu Thr Glu Leu Tyr L,eu Tyr Asn Asn Met Ile Ala Lys Ile Gl.n Glu Asp Asp Phe Asr. Asn Leu Asn Gln Leu Gln Ile Leu Asp Leu Ser G1y Asn Cys Pro Arg Cys 'I'yr Asn Ala Pro Phe Pro Cys Ala Pro Cys Lys Asn Asn Ser Pro Leu Gln Ile Pro Val Asn Ala Phe Asp Ala Leu Thr Glu I,eu Lys Val Leu Arg Leu His Ser Asn Ser Leu Gln His Val Pro Pro Arg 'Irp Phe Lys Asn Iie Asn Lys heu Gln Glu Leu Asp heu Ser Gln Asn Phe Leu Ala Lys Glu I1e Gly Asp Ala Lys Phe Leu His PY:e Leu Pro Ser Leu Ile Gln Leu Asp Leu Ser Phe Asn Phe G1u Leu Gln Val Tyr Arg Ala Ser Met Asn Leu Ser Gln Ala Phe Ser Ser Leu Lys Ser Leu Lys Ile Leu Arg Ile Arg Gly Tyr Val F'he Lys Glu Leu Lys Ser Phe Asn Leu 380 3E?5 390 Ser Pro Leu His Asn Leu Gln Asn Leu G7u Val Leu Asp Leu Gly Thr Asn Phe Ile Lys I:le Ala A:n Leu Ser Met Phe Lys Gl.n Phe Lys Arg Leu Lys Val Ile Asp Leu Ser Val Asn Lys Ile Ser Pro Ser Gly Asp Ser Ser Glu '.Jal G:.y Phe Cys Ser Asn Ala Arg Thr Ser Val Glu Ser Tyr Glu Pro Gn Val Leu Glu Gln Leu His Tyr 455 4E>0 965 Phe Arg Tyr Asp Lys Tyr Ala Aag Ser Cys Arg Phe Lys Asn Lys 970 4?5 980 Glu Ala Ser Phe Met Ser 'Jal A~u Glu SEer Cys Tyr Lys Tyr Gly Gln Thr Leu Asp Leu Ser Lys Asn Ser Ile Phe Fhe Val hys Ser Ser Asp Phe Gln His Leu Ser Phe Leu Lys Cys Leu Asn Leu Ser Gly Asn Leu Ile Ser G1n Thr Leu Asn Gly Ser Glu Phe Gln Pro 530 5 .5 540 Leu Ala Glu Leu Arg Tyr Leu A_p Phe Ser Asn Asn Arg Leu Asp Leu Leu His Ser Thr Ala Phe GLu Gl,z Leu His hys Leu Glu Val Leu Asp Ile Ser Ser Asn Bier Hs Tyr Phe Gln Ser Glu Gly Ile Thr His Met Leu Asn Phe Thr Lys Asn Leu Lys Val Leu G1n Lys Leu Met Met Asn Asp Asn Asp Tle Ser Ser Ser Thr Ser Arg Thr Met Glu Ser Glu Ser Leu Arg Thr Leu Glu Phe Arg Gly Asn His Leu Asp Val Leu Trp Arg Gl-s Gly Asp Asn Arg Tyr Leu Gln Leu Phe Lys Asn Leu Leu Lys Leu Giu Glu Leu Asp Lle Ser hys Asn Ser Leu Ser Phe Leu Pro Ser Gly Val Phe Asp Gly Met Pro Pro 665 6''0 675 Asn Leu Lys Asn Leu Ser Leu Aa Lys Asn Gly I~eu Lys Ser Phe Ser Trp Lys Lys Leu Gln !Jys Lc~u L ys Asn Leu Glu Thr Leu Asp Leu Ser His Asn Gln Leu Thr Thr Val Pro G1u Arg Leu Ser Asn 710 7_~5 720 Cys Ser Arg Ser Leu Lys Asn heu I've Leu Lys Asn Asn Gln I1e Arg Ser Leu Thr Lys Tyr Phe Lc-u Gln Asp Ala Phe Gln Leu Arg Tyr Leu Asp Leu Ser Ser Asn Lys Ile Gln Met Ile Gin Lys Thr Ser Phe Pro Glu Asn Val Leu A:sn As:~ Leu Lys Met Leu Leu Leu 770 7'75 780 His His Asn Arg Phe Leu Cys Thr Cys A:>p A1a Val Trp Phe Val Trp Trp Val Asn His Thr Glu Vai '?'hr Iie Pro Tyr Leu Aia Thr Asp V al Thr Cys Val Gly Pro Giy Ala H.is Lys Gly Gln Ser Val 815 8:?0 825 3~j9 Ile Ser Leu Asp Leu Tyr ~'hr C}~~s Glu Leu Asp Leu Thr Asn Leu 830 8~.5 890 Ile Leu Phe Ser Leu Ser Iie Ser Val Se:r Leu Phe Leu Met Val Met Met Thr Ala Ser His L.eu 'ryr FOe TrP: Asp Val Trp Tyr Ile Tyr His Phe Cys Lys Ala Lys Ile l.ys Gly Tyr Gln Arg Leu Ile 8'75 880 885 Ser Pro Asp Cys Cys Tyr Asp Ala Prue Ile Val 'Iyr Asp Thr Lys Asp Pro Ala Val Thr Glu Trp Val heu Ala Glu Leu Val Ala Lys Leu Glu Asp Pro Arg Glu Lys Hps Phe Asn Leu Cys Leu Glu Glu 920 9~' '; 930 Arg Asp Trp Leu Pro Gly Gln Pro Val Leu Glu Asn Leu Ser Gln Ser Ile Gln Leu Ser Lys Lys Thr Val Phe Val Met Thr Asp Lys Tyr Ala Lys Thr G.lu Asn Phe Lys I:le Ala Phe Tyr Leu Ser His Gln Arg Leu Met Asp Glu ~y5 Va,l Asp Val Ile Ile Leu Ile Phe Leu Glu Lys Pro Phe Gln Lys Ser Lys Phe Leu Gln Leu Arg Lys Arg Leu Cys Gly Ser Ser 'Jal Leu Glu Trp Pro Thr Asn F'ro Gln Ala His Pro Tyr Phe Trp Cln Cys Leu Lys Asn Ala Leu Ala Thr 1.02.5 10 30 1035 Asp Asn His Val Ala Tyr Ser Gln Val Pt:e Lys Glu Thr Val 1090 10~1_'~
<210> 497 <211.> 9199 <2i2> DNP, <213> Homo sapiens <900> 49i gggtaccatt ctgcgctgct gcaagttacg gaat<xaaaaa t.tagaacaac 50 agaaacatgg aaaacatgtt cc~;tcagtcg tcaai_gctga cctgcatttt 100 cctgctaata tctggttcct gtgagttatg cgccgaagaa aattttt~uta 150 gaagctatcc ttgtgatgag aaaaagct,;aa atgactcagt tattgcagag 200 tgcagcaatc gtcgactaca ggaagttccc caaacggtgg gcaaatatgt 250 gacagaacta qacctgtctg ataatttcat cacacacata acgaatgaat 300 ?3'~

catttcaagg gctgcaaaat ctcactaaaa taaatctaaa ccacaacccc 350 aatgtacagc accagaacgg as<it<:ccqgt atacaat.caa atggcttctaa 400 tatcacagac ggggcattcc tcaac.:ctaaa aaacctaagg gagttactgc 450 ttgaagacaa ccagttaccc: ca<~atacc:ct ct:ggtttgcc agagtctt:tg 500 acagaactta gtctaattca aaacaatata tacaacataa ctaaagaggg 550 catttcaaga cttataaact: tgaaaaatct ctatttqgc:c tggaactc~ct 600 attttaacaa agtttgcgag aauactaGca t.agaagatgg agtatt:tgaa 650 acgctgacao atttggagtt: gct;atcacta tctttcaatt ctctttcaca 700 cgtgccaccc aaactgccaa gct.ccctacg caaactvtt:t ctgagcaaca 750 cccagatcaa atacattagt gaagaagatt tcaagggatt gataaattta 800 acattactag atttaagcgg garzctgtc:cg <~ggtctcttca atgccccatt 850 tccatgcgtg ccttgtgatg gtggtgcttc aattaatata gatcgttttg 900 cttttcaaaa cttgacccaa cttcg atacc tasaac:ctctc tagcacttcc 950 ctcaggaaga ttaatgctgc ctggtttaaa aatat.gcctc atctgaaggt 1000 gctggatctt gaattcaact= atttagtqgg agaaatagtc tctggggcat 1050 ttttaacgat gctgccccgc tt~agaaatac t:tgacatgtc t:tttaactat 1100 ataaagggga gttatccaca gcata ttaat atttccagaa acttctctaa 1150 acttttgtct ctacgggcat tgcattt<_ag aggtt:atgtg ttcc:aggaac 1200 tcagagaaga tgatttccag cccctgaigc agcttccaaa cttatcgact 1250 atcaacttgg gtattaattt r_attaag<aa a~tcgatttca aacttttcca 1300 aaatttctcc aatctggaaa ttatttac:tt gtcagaaaac agaatatcac 1350 cgttggtaaa agatacccgg cac.~agtt<zta caaat:agttc ctcttt.tcaa 1900 cgtcatatcc ggaaacgacg ctcaacaqat tttg<:gtttg acccacattc 1450 gaacttttat catttcaccc gtcctttaat aaagccacaa tgtgctgctt 1500 atggaaaagc: cttagattta agcctcaa-aca gtattttctt cattgggcca 1550 aaccaatttg aaaatcttcc tgacattgcc tgttl=aaatc tgtctgcaaa 1600 tagcaatgct:. caagtgttaa gtggaactga attttcaqcc attcct.catq 1650 tcaaatattt ggatttgaca aacaatagac tagactttga taatgctagt 1700 gctcttactg aattgtccga ctt.ggaac~t t ctagatctca c7ctataattc 1750 acactatttc agaatagcag gcgtaacaca tcatctagaa tttattcaaa 1800 atttcacaaa tctaaaagtt ttaaacttga gccacaacaa catttatact 1850 ttaacagata agtataacct ggaaagcaag tccctggtag aattagtttt 1900 cagtggcaat cgcct.tgaca tttt:gtggaa tgatgatgac aacaggtata 1950 tctccatttt caaaggtctc aagaatctga cacgtctgga tttatccctt 2000 aataqgctga agcacatccc aaatgaagca t.tc~cttaat,t tgccagcgag 2050 tctcactgaa ctacatataa atcrat:aatat. gt;taaagttt tttaactgga 2100 cattactcca gcagtttcct cgtct:cgagt tgcttgactt acgtggaaac 2150 aaactactct ttttaactga tac;c<:tatct gactttacat cttcccttcg 2200 gacactgctg ctgagtcata acaggatttc ccacctaccc tctggctttc 2250 tttctgaagt cagtagtctg aagcacctcg attaaagttc caat,ctgca.a 2300 aaaacaatca acaaatccgc acttgaacct aagaccacca ccaaattatc 2350 tatgttggaa ctacacggaa acc:cctttga cstgcacctgt gacattggag 2400 atttccgaag atggatggat gaacatctga atgtcaaaat tcccagactg 2950 gtagatgtca tttgtgccag tcctggggat c:aaagaggga agagtattgt 2500 gagtctggag ctaacaactt. gt<ttttcaga tgtcactgca gtgatatt:at. 2550 ttttcttcac: gttctttatc accaccatgg ttatgtt:ggc tgccctggc:t 2600 caccatttgt tttactggga tgtti=ggttt atatataatg tgtgtttagc 2650 taaggtaaaa ggctacaggt ctctttccac atcccaaact ttctatgatg 2700 cttacatttc ttatgac acc: aaa gatgcct ctgtta<vtga ctgggtgata 2750 aatgagctgc gctaccacct tgaagagagc cgagacaaaa acgttctcct 2800 ttgtctagag gagagggatt gggac:cccrgg att.ggccatc atcgacaacc 2850 tcatgcagag catcaaccaa ag<:aagaaaa cagtatttgt tttaaccaaa 2900 aaatatgcaa aaagc:tggaa ctttaaaa,ca gc:ttt tt:act tgg<attgca 2950 gaggctaatg gatgagaaca tgg atgtqat t:atat:t:tatc ctgctggagc 3000 cagtgttaca gcatt:ctcag tatttgacgc tacgdcagcg gatctgtaag 3050 agctccatcc tccagtggcc: tgacaacccg aaggcagaag gcttgttttg 3100 gcaaactctg agaaatgtgg tcttgactga aaatgattca cggtataaca 3150 atatgtatgt cgatt:ccatt aagcaata:ct aactga~:vgtt aagtcatgat 3200 ttcgcgccat aataaagatg caaagga<:tg acatttctgt attagttatc 3250 tattgctatg taacaaatta tcccaaaact t.agtg gt.tta aaacaacaca 3300 tttgctggcc cacagttttt gagggtcagg agtcc:aggcc cagcataact 3350 gggtcctctg ctcagggtgt ctcagagctct gcaai:gtagg tgttcaccag 3400 agacataggc atcactgggg tcacactcat gtggi:tgttt t.ctggattca 3950 33-i attcctcctg ggctattggc caaaggctat ar_.tcatqtaa gccatgcgag 3500 cctctcccac aaggcagctt gcttcatcag agctagcaaa aaagagaggt 3550 tgctagcaag atgaagt~ac aat:cttttgt aatcgaatca aaaaagtgat 3600 atctcatcac tttggccata ttrtatttgt t.agaagtaaa ccacaggtcc 3650 caccagctcc atgggagtga ccacctcagt ccagggaaaa cagctgaaga 3700 ccaagatggt gagctctgat tgett=cagtt ggtcatc:aac tattttccct 3750 tgactgctgt cctgggatgg cctgctatca t:g<stgataga ttgtgaatat 3800 caggaggcag ggatcactgt ggacc:atctt agc.agttgac ctaacacatc 3850 ttcttttcaa tat.ctaagaa cttttgcc:ac tgtgactaat ggtcctaata 3900 ttaagctgtt gtttatattt at<:.atat.atc t:atggctaca tggttatatt 3950 atgctgtggt tgcgttcggt tttatttac:a gttgctttta caaatatttg 4000 ctgtaacatt tgacttctaa ggtttagatg cc:atttaaga actgagatgg 9050 atagctttta aagcatcttt tac:tt:cttac c.attttt:taa aagtatgc:ag 4100 ctaaattcgo agcttttggt ctzitattgtt aattgccatt gctgtaaatc 9150 ttaaaatgaa tgaataaaaa tgtttcattt tacaaaaaaa aaaaaaaaa 4199 <210> 998 <211> 1091 <21.2> PRT
<213> Homo Sapiens <::400> 498 Met Glu Asn Met Phe Leu (~ln Ser Ser Met Leu T'hr Cys Ile Phe Leu Leu Ile Ser Gly Ser (.",ys Gnu Leu Cys Ala Glu Glu Asn Phe Ser Arg Ser Tyr Pro C:ys Asp Glu Lys Lys Gln Asn Asp Ser Val Ile Ala Glu Cys Ser Asn Flrg Arg Leu Gl n Glu Val Pro G'ln Thr Val Gly Lys Tyr Val Thr Glu Leu Asp Leu Ser Asp Asn PYie Ile Thr His Ile Thr Asn Glu Ser PY!e Gln Gly Leu Gln Asn Leu Thr Lys Ile Asn Leu Asn His Asn Pro Asn Val Gln His Gln Asn Gly Asn Pro Gly Ile Gln Ser Asn Gl.y Leu Asn Ile Thr Asp Gly Ala Phe Leu Asn Leu Lys Asn Lea Arg Glu Leu Leu heu Glu Asp Asn 125 1;'s0 7 35 Gln Leu Pro Gln Il.e Pro Ser Gly Leu Pro Glu Ser Leu Thr Glu Leu Ser Leu Ile Gln Asn Asn Ile Tyr Asn Ile Thr Lys Glu Gly Ile Ser Arg Leu Ile Asn Leu Lys Asn Leu Tyr Leu Al.a Trp Asn Cys Tyr Phe Asn Lys 'Jal Cys Gln Lys Thr Asn Ile Glu Asp Gly Val Phe Glu Thr Lea Thr ~~sr~ Leu GlLn Leu Leu Ser Leu Ser Phe 200 20~: 210 Asn Ser Leu Ser His Val Pro Pro Lys Leu Pro Ser Ser Leu Arg '215 220 225 Lys Leu Phe Leu Ser Asn Thr Gln Ile Lys Tyr Iie Ser Glu Glu Asp Phe Lys Gly Leu Ile Asn Leu Thr Leu Leu Asp Leu Ser Gly 2_.45 250 255 Asn Cys Pro Arg Cys Phe Asn Ala Fro Pre Pro Cys Val Pro Cys Asp Gly Gly Ala Ser Ile Asn Ile Asp Arg Phe Ala Phe Gln Asn Leu Thr Gln l,eu Arg Tyr heu Asn Leu Ser Ser Thr Ser Leu Arg Lys Ile Asn Ala Ala Trp Phe Lys Asn Met Pro His Leu Lys Val Leu Asp Leu Gl.u Phe Asn '1'yr LEU Vai Gly Glu Ile Val Ser Gly Ala Phe Leu Thr Met Leu Pro Arg I~eu Glu Ile Leu Asp Leu Ser Phe Asn Tyr Iie Lys Gly Ser Tyr Fro Gln His Ile Asn Ile Ser Arg Asn Phe Ser Lys Leu Leu Ser Leu Arq Ala Leu His Leu Arg 365 3:'0 375 Gly Tyr Val Phe Gln Glu Leu Arg Glu Asp Asp Phe G1n Pro Leu Met Gln Leu Pro Asn Leu Ser Tt:r Il.e Asn Leu Gly Il.e Asn Phe Ile Lys Glr. Ile Asp Phe Lys LE~u Phe G-n Asn Phe Ser Asn Leu 41 0 9 _.5 420 Gl.u Ile Ile Tyr Leu Ser GIu A:>n Arg Ile Ser Pro Leu Val Lys Asp Thr Arg Gln Ser Tyr Ala Asn Ser Ser Ser Phe Gln Arg His Ile Arg Lys Arg Arg Ser Thr Asp Phe Glu Phe Asp Pro His Ser 45', 460 965 Asn Phe Tyr His Phe Thr Arg Pro Let. Ile Lys Pro Gln Cys Ala Ala Tyr Gly Lys Ala Leu Asp Leu Ser Leu Asn Ser Ile Phe Phe 98w 490 495 Ile Gl.y Pro Asn Gln Phe Glu Asn Leu Pro Asp Ile Ala Cys Leu Asn Leu Ser Ala Asn Ser Asn Ala Gln Val Leu Ser Gly Thr Glu Phe Ser Ala Ile Pre His Va_ Lys Tyr Leu Asp Leu Thr Asn Asn Arg Leu Asp Phe Asp Asn Flla Ser i~l.a Leu T'hr Glu Leu Ser Asp Leu Glu Vas L~eu Asp Leu Ser Tyr Asn Ser Hi.s Tyr Phe Arg Ile 560 SE~: 570 Ala Gly Val Thr His His Leu Glu Phe Ile Gln Asn Phe Thr Asn Leu Lys Val Leu Asn Leu Ser His Asn Asn Ile Tyr Thr Leu Thr Asp Lys Tyr Asn Leu Glu ,'3e; Lys Ser Leu Val Glu Leu Val Phe Ser Gly Asn Arg Leu Asp =l:lc= Leu Trp A:;n Asp Asp Asp Asn Arg Tyr Ile Ser Ile Phe Lys Gly LE-a Lys A~:n Leu Thr Arg Leu Asp Leu Ser Leu Asn Arg Leu »ys His Ile Fro Asn Glu Ala Fhe Leu 650 6'_;5 660 Asn Leu Prc A.la Ser T~eu Thr Glu Leu His I:Le Asn Asp Asn Met 665 6;0 675 Leu Lys Phe Phe Asn Trp Thr LE-a Len Gln G.ln Phe Pro Arg Leu Glu Leu Leu Asp Leu Arg Gly A;;n Lys Leu Leu Fhe Leu Thr Asp Ser Leu Ser Asp Phe Thr S er Ser Leu Arg Thr Leu Leu Leu Ser 7i0 7_5 720 His Asn Arg Ile Ser His Leu Pro Ser G=~y Phe Leu Ser Glu Val Ser Ser Leu Lys Hi.s Leu Asp LE~u Ser Ser Asn Leu Leu Lys Thr Ile Asn Lys Ser Ala Leu Glu Thr Lys Thr Thr Thr Lys Leu Ser 3 9 ~~

Met Leu Glu Leu His Gly Asn Pro I?he Glu Cys Thr Cys Asp Ile Gly Asp Phe Arg Arg 'I'rp Met. Asp Glu His Leu Asn Val Lys Ile Pro Arg Leu Val Asp Va1 Ile Cys Ala Se-r Pro Gly Asp Gln Arg Gly Lys Ser Lle Val Ser Leu G1 a Leu Tl-:r 7.'hr Cys Val Ser Asp 815 8~0 825 Val Thr Aia Val Ile Leu I?he Pk~e Ftie Thr Phe Phe Ile Thr Thr 830 8~;5 840 Met Val Met Leu Ala Ala l.~eu Alaj His His Leu Phe Tyr Trp Asp 845 8'_~0 855 Val Trp Phe Ile Tyr Asn Va:1 Cys Leu Ala Lys Val Lys Gly Tyr Arg Ser Leu Ser Thr. Ser Gln Thr Phe Tyr Asp Al.a Tyr Ile Ser Tyr Asp Thr Lys Asp A.la Ser Val Thr Asp Trp Val Ile Asn Glu Leu Arg Tyr His Leu Glu (:~lu Ser Arg Asp Lys Asn Val Leu Leu 905 97_0 915 Cys Leu Glu Glu Arg Asp 'Lrp Ap Pro G'_y Leu Ala Ile Il.e Asp Asn Leu Met Gln Ser Ile Asn Gln Se:r Lys Lys Thr Val Fhe Val Leu Thr Lys Lys Tyr Ala Lys SE~r Tr.p A;n Phe hys Thr Ala Phe 950 9'.5 960 Tyr Leu Ala Leu Gln Arg l_~eu Mf.~t Asp Glu Asn Met Asp Val Ile 965 9'70 975 Iie Phe Ile Leu Leu Glu Pro V;:cl Leu GLn His Ser Gln Tyr Leu Arg Leu Arg Gln Arg Ile '~ys Lys Ser Ser Ile T~eu Gln Trp Pro 995 10()0 1005 Asp Asn Prc Lys Ala Glu Gly Lc:u Phe Trp Gln Thr Leu Arg Asn Val Val Leu Thr Glu Asn Asp Ser Arg Tyr Asn Asn Met Tyr Val Asp Ser Ile L:ys Gln 'ryr <210> 499 <211> 20 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-2.0 <223> Artificial Seauence <400> 499 taaagaccca gctgtgaccg 20 <210> 500 <211> 20 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-20 <223> Artificial Sequence <900> 500 atccatgagc ctctgatggg 20 <210> 501 ~211> 95 <2i2> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-45 <223> Artificial Sequence <900> 501 atttatgtct cgaggaaagg gactggttac cagggcagcc agttc 95 <210> 502 <211> 21 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-21 <223> Artificial Sequence <400> 502 gccgagacaa aaacgttctc c 21 <210> 503 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequa_nce <222> 1-24 <223> Arti.fi.cial Sequence <900> 503 catccatgtt ctcatccatt agcc 29 <210> 509 <211> 96 <212> DNA

<213> Artificial <220>
<221> Artificial Sequence <222> 1-46 <223> Artificial Sequence <400> 504 tcgacaacct catgcagagc atcaaccaaa gcaagaaaac agtatt 46 <210> 505 <211> 1738 <212> GNA
<213> Homo sapiens <900> 505 ccaggtccaa ctgcacctcg gttctatc:la ttgaattccc cggggatc:ct 50 ctagagatcc ctcgacctcd acccacgcgt ccgccaagct ggccctgcac 100 ggctgcaagg gaggctcctg tggacagg:c aggcaggtgg gcctcaggag 150 gtgcctccag gcggccagtg ggcctgaggc ccc:agcaagg gctagggtcc 200 atctccagtc ccaggacaca gcagcggcca ccatggccac gcctgggctc 250 cagcagcatc agcagccccc aggaccgggg aggcacaggt ggcccccacc 300 acccggagga gcagctcctg ccc.ctgtccg ggggatgact gattctcctc 350 cgccaggcca cccagaggag aaqgccaccc cgcctggagg cacaggccat 900 gaggggctct caggaggtgc tgc-tgatgtg gcttctggtg ttggcagtgg 450 gcggcacaga gcacgcctac cggcccggcc gt:agggtgtg tgctgtccgg 500 gctcacgggg accctgtctc cgagt=cgttc gtgcagcgtg tgtaccagcc 550 cttcctcacc acctgcgacg qgc:accgggc. ~tgcagc:acc taccgaacca 600 tctataggac cgcctaccgc cgcagccctg ggctggcccc tgccaggcct 650 cgctacgcgt gctgccccgg ctcagaagagg accagcgggc ttcctggggc 700 ctgtggagca gcaatatgcc agc:c<xccatg ccggaacgga gggagctgtg 750 tccagcctgg ccgctgccgc: tgc:cctgcag gatggcc,~ggg tgacactt=gc 800 cagtcagatg tggatgaatg cagtgctagg ag gggcggct gtccccagcg 850 ctgcatcaac accgccggca gtt:.act.ggtg c:cagtgt:tgg gaggggca ca 900 gcctgtctgc agacggtaca ctctgtgtgc ccaagggagg gccccccagg 950 gtggccccca acccgacagg agtggacagt gcaatgaagg aagaagtgca 1000 gaggctgcag tccagggtgg acctgctgga ggagaagctg cagctggtgc 1050 tggccccact gcacagcctg gcctcgcagg cactggagca tgggctcccg 1100 gaccccggca gcctcctggt gcactccttc cagcagctcg gccgcatcga 1150 ctccctgagc gagcagattt cctt~~ctUga ggagcagctg gggtcctgct 1200 cctgcaagaa agactcgtga ctgcccagcg ccccaggca g gactgagccc 1250 ctcacgccgc cctgcogccc ccatgccc:~t gc:c:caacatg ctgggggtcc 1300 agaagccacc tcggggtgac tgagcggaag gccaggcagg gccttcctcc: 1350 tcttcctcct ccccttcctc gggaggctcc cc:agacc<:tg gcatgggatg 1400 ggctgggatc ttctct:gtga atc<:acccct ggctaccccc accctggcta 1950 ccccaacggc atcccaaggc caggtgggcc ct.cagctgag ggaaggtacg 1500 agctccctgc tggagcctgg gac:ccatg~c acaggccagg cagcccggag 1550 gctgggtggg gcctcagtgg ggc:ctgct:g c ctgaccccca gcacaataaa 1600 aatgaaacgt gaaaaaaaaa aa<:aaaaaaa aaaaaaaaaa a,saaaaaoaa 1650 aaagggcggc cgcgactcta gagtcgact gcagaagctt ggccgccatg 1700 gcccaacttg tttattgcag cttat:aatgg ttacaaat 173 <210> 506 <211> 273 <212> PRT
<213> Homo Sapiens <400> 506 Met Arg Gly Ser Glr: Glu Val Leu Leu Met Trp Leu Leu Val Leu 1 ~ 10 15 Ala Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val Cys Ala Val Arg Ala His Gly Asp Fro Val Ser Glu Ser Phe Val Gln Arg Val Tyr Gln Fro F'he Leu Thr Thr Cys Asp Gly His Arg 0 ' 60 Ala Cys Ser Thr Tyr Arg ,'hr Lle Tyr Arg Thr AIa Tyr Arg Arg 65 i0 75 Ser F'ro Gly Leu Ala Pro Ala Arg Fro Arc, 'T'yr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser my Leu Pro Gly Ala Cys Gly Ala Ala Ile Cys Gln Fro Pro C;ys Arcl A:,n Gly Gly Ser Cys Val Gln Fro Gly Arg Cys Arg Cys Pro Ala Gly Trp Arg Gly Asp Thr Cys Gln Ser Asp Val Asp Glu Cys Ser Ala Arg Arg Gly Gly Cys Pro Gln Arg Cys Ile Asn Thr Ala Gly Seer Tyr Trp Cys Gln Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thr Leu Cys Val Pro Lys Gly 1'70 175 180 Gly Pro Pro Arg Val Ala Frc> Asn Prc> Thr Gly Val Asp Ser Ala Met Lys Glu Glu Vai ~ln Arq_ Leu Glni Ser Arg Val Asp Leu Leu Glu Glu Lys Leu Gln Leu ~.'al Leu Ala Pro Leu His Ser Leu Ala 21c~ 220 225 Ser Gln Ala Leu Glu His: Cly Leu Fro Asp Pro Gly Ser Leu Leu 2 30 23'_~ 240 Val His Ser Phe Gln Gln L~eu Gly Arg Ile Asp Ser Leu Ser Glu ~95 25C? 255 Gln Ile Ser Phe Leu Glu C~lu Gln hc:u Gly Ser Cys Ser Cys Lys Lys Asp Ser <210> 507 <211> 1700 <212> DNA
<:213> Homo sapiens <90C> 507 gccaggcagg tgggcctcag gac~gtgcctc caggc:ggcca gtgggcctga 50 ggccccagca agggctaggg tcc:atctcca gtcccaggac acagcagcgg 100 ccaccatggc cacgcctggg ct~:cagcagc atcagagcag cccc.tgtggt 150 tggcagcaaa gttcagcttg gctgggcccg ctgtgagggg cttcgcgct.a 200 cgccctgcgg tgtcccgagg gctgaggtct cctcat<a tc tcccaagcag 250 tggatgagca acccaacggg gg<;ccggcga gggg<iactgg cccc.:gaggga 300 gaggaacccc aaagccacat ctgtagc<:ag gatgagcagt gtgaatccag 35C
gcagccccca ggaccgggga ggcacaggtg gcccccacca ccccxgaggag 400 cagctcctgc ccctgtccgg gggatgacag attctcctcc gccaggccac 950 ccagaggaga aggccacccc gcctggacagc acaggcc:atg aggggctctc 500 aggaggtgct gctgatgtgg cttctggv.gt tggc<3gtggg r:ggcacagag 550 cacgcctacc ggcccggccg tagggtg?.gt gctg-cc:ggg cacacgggga 600 ccctgtct.cc gagtcgttcg tgcagcgt:.gt gtacc;agccc ttcctcacca 650 cctgcgacgg gcaccgggcc tgcagcac;ct accgaaccat ctataggacc 700 gcctaccgcc gcagccctgg gctggcc~.wa gccaggcctc gctacgcgtg 750 ctgccccggc tggaagagga ccagcgggct tcctggggcc t=gtggagcag 800 caatatgcca gccgccatgc cggaacggag ggagctgtgt c cagcctggc 850 cgctgccgct gccctgcagg atggc:ggggt gacacttgcc agtcagatgt 900 ggatgaatgc agtgctagga ggggcggctg tccccagcgc tgcatcaaca 950 ccgccggcag ttactggtgc cagtgttggg aggggcacag cctgtctgca 1000 gacggtacac tctgtgtc~cc caagcagaggg ccccccaggg tggcccccaa 1050 cccgacagga gtggacagtg caatgaagga ag aagtgcag aggctgcagt 1100 ccagggtgga cctgctggag gagaagctgc agctggtgct ggccccac:tg 1150 cacagcctgg cctcgcaggc actggagcat gggctc:ccgg accccggcag 1200 cctcctggtg cactccttcc agcagctcgg ccgcatcgac tccctgagcg 1250 agcagatttc cttcctggag gagcagctgg ggtcctgctc ctgcaagaaa 1300 gactcgtgac tgcccagcgc tcc:aggctgg a<a gagcccc tcacgccgcc 1350 ctgcagcccc catgcccctg cccaacatgc tgggggtcca gaagccac:ct 1900 cggggtgact gagcggaagg ccaggcaggg ccttc:ct:cct cttcctcctc 1950 cccttcctcg ggaggctccc cadaccctgg catgggatgg gctgggatct 1500 tctctgtgaa tccac:ccctg qct:ac~cccua ccctc~gc;tac cccaacggca 1550 tcccaaggcc aggtggaccc tcagctgagg gaaggtacga gctc:cctgct 1600 ggagcctggg acccatggca caggcdcacgc agcccggagg ctgggtgggg 1650 cctcogtggg ggctgctgcc tgacccccag cacaataaaa atgaaacgtg 1700 <210> 508 <211> 273 <212> PRT
<213> Homo sapiens <900> 508 Met Arg Giy Ser Gln Glu 'Ja1 Leu Leu Met Trp Leu Leu Val Leu 1 5 =0 15 Ala Val Gly Gly Thr Glu His Ala Tyr Arg Pro Gly Arg Arg Val ~0 a5 30 Cys Ala Val Arg Ai.a His Gly App Pro Val Ser Glu Ser Phe Val Gln Arg Val Tyr Gln Pro Phe LE~u Thr Thr Cys Asp Gi.y His Arg Ala Cys Ser Thr Tyr Arg Thr I!e Tyr Arg Thr Ala Tyr Arg Arg E.5 70 75 Ser Pro G1y Leu Ala Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly Trp Lys Arg Thr Ser e~ly Leu Pro Gly Ala Cys Gly Ala Ala Ile Cys Gl.n Pro Pro Cys Arg Asn Gly Gly Ser Cys Val Gln Pro Gly Arg Cys Arg Cys Pro Ala Gly Trp Arg Gly Asp Thr Cys Gln Ser Asp Val Asp Glu c:ys Ser Ala Arg Arg C7ly G.ly Cys Pro Gln Arg Cys Ile Asn Thr Ala C;ly Ser Ty:r Trp C:ys Gln Cys Trp Glu Gly His Ser Leu Ser Ala Ash. Gly Thr Leu Cys Val Pro Lys Gly Gly Pro Pro Arg Val Ala Fro Asn Pros Thr Gly Val Asp Ser Ala Met. Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp Leu Leu Glu Glu Lys Leu Gln Leu Val Leu Ala Pro Leu His Ser Leu Ala Ser Gln Ala Leu Glu His C;ly Leu Pro Asp Prc Gly Ser Leu Leu Val His Ser Phe Gln Gln Let. Gly Arg Ile Asp Ser Leu Ser Glu 29': 250 255 Gln lie Ser Phe Leu Glu ~~lu Gin Leu Gly Ser Cys Ser Cys Lys Lys Asp Ser <210> 509 <211> 1538 <21.2> I~NA
<213> Homo Sapiens <400> 509 cccacgcgtc cgaagctggc cct.gcacggc tgcaagggag gctcctgtgg SO
acaggccagg caggtgggcc: tcaggaggtg cctcc:aggcg gccagtgggc 100 ctgaggcccc agcaagggct: agggtccatc tc:cagtccca ggacacagca 150 gcggccacca tggccacgcc tgggctccag cagcat~:.agc agcccccagg 200 accggggagg cacaggtggc ccccaccacc cggaggagca gctcctgccc 250 ctgtccgggg gatgactgat: tc':cctccgc c:aggccaccc agaggagaag 300 gccaccccgc ctggaggcac agc~ccatgag gggctctcag gaggtgctgc: 350 tgatgtggct tctggtgttg gcagtgggcg gcacagagca cgcctaccgg 400 cccggccgta gggtgtgtgc tgtccgggct c.acgdggacc ctgtctccga 950 gtcgttcgtg cagcgtgtgt accagccc.vt.t cctc<3ccacc t.gcgacgggc 500 accgggcctg cagcacctac cgaaccat.ct ataggaccgc c:taccgccgc 550 agccctgggc tggcccctgc caggcctc:gc tacgcgt:gct gccccggctg 600 39'i gaagaggacc agcgggcttc: ctggggcct:g tggagcagca atatgccagc 650 cgccatgcc:g gaacggaggc~ agc:t:gtgt~,c agc:ctggccg ci=gccgctgc 700 cctgcaggat ggcggggtga cacttgccag t<:agatgtgg atgaatgcag 750 tgctaggagg ggcggctgtc; cccagcgctg cgt;caacacc g<:cggcagtt 800 actggtgcca gtgttgggag gggcacagcc tgtctgcaga cggtacactc 850 tgtgtgccca agggagggcc: ccccagggtg gc:ccccaacc cgacaggagt 900 ggacagtgca atgaaggaag aagtgcagag gct:gcagtcc agggtggacc 950 tgctggagga gaagctgcag ctc:gtgctgg ccccactgca cagcctggcc 1000 tcgcaggcac tggagcatgg gctcccgg:3c c;c<:ggcagc:c tcctggtgca 1050 ctccttccag cagctcggcc gcatc:gactc cctgagcgag cagatttcct 11.00 tcctggagga gcagctgggg tcctqctcct gcaagaaaga ctcgtgactg 1150 cccagcgccc caggctggao tgagc:ccct.c ac.gccgccct gcagccccca 1200 tgcccctgcc caacatgctg ggc;gt:ccaga agccacctcg gggtgactga 1250 gcggaaggcc aggcagggcc ttcctcctct tcctcctcc:c cttcctcggg 1300 aggctcccca gaccctggca tgr~g<~tgcgc t:gggatcttc tctgtgaatc 1350 cacccctggc tacccccacc ctqgctaccc caacggc:atc ccaaggc<;ag 1400 gtgggccctc agctgaggga aggtacgagc tc,cctgctgg agcctggqac 1950 ccatggcaca ggccaggcag cc<:ggaggct gggtggggcc tcactggggg 1500 ctgctgcctg acccccaqca caataaaaat gaaacqtq 1_'>38 <210> 510 <211> 273 <212> PRT
<213> Homo sapiens <400> 510 Met Arg Gly Ser Gln Glu Val hEU Leu Met Trp heu Leu Val Leu Ala Val Gly Gly Thr Glu His Ana Tyr Arg Pro Gly Arg Arg Val Cys Ala Val Arg Ala His Gly Asp Fro Val Ser Glu Ser Phe Val Gln Arg Val Tyr Gln Pro Phe Lea Thr Thr Cys Asp G1y His Arg 50 '.~5 6O
Ala Cys Ser Thr Tyr Arg Thr I.:e Tyr Arg Thr Ala Tyr Arg Arg 65 '/0 75 Ser Pro Gly Leu Ala Pro Ala Arg Pro Arg Tyr Ala Cys Cys Pro Gly~ Trp hys Arg Thr Ser Gly Leu Pro Gly Ala Cys Gly Ala Ala Ile Cys Gln Pro Pro Cys Arg Asn Gly Gly Ser Cys Val Gln Pro Gly Arg Cys Arg Cys Pro Ala Gly Trp Arg Gly Asp Thr Cys Gln 125 1 ii) 135 Ser Asp Val Asp Glu Cys Ser Ala Arg Arg Gly Gly Cys Pro Gln 140 14.5 150 Arg Cys Val Asn Thr Ala Gl.y Ser Tyr Trp Cys Gln Cys Trp Glu Gly His Ser Leu Ser Ala Asp Gly Thx Leu C:ys Val Pro Lys Gly Gly Pro Pro Arg Val Ala Prc Asr: Prcs Thr Gly V<sl Asp Ser Ala Met Lys Glu Glu Val Gln Arg Leu Gln Ser Arg Val Asp Leu Leu Glu Glu Lys Leu Gln i~eu Val Leu Ala Pro Leu His Ser Leu Ala Ser Gln Ala Leu Glu Flis C~ly Lei: Prc; Asp Pro Gly Ser Leu Leu 230 23'_~ 290 Val His Ser Phe Gln Gln L,eu Gly Arg Ile Asp Ser Leu Ser Glu Gln Ile Ser Phe Leu Glu C:lu Gln Leu Gly Ser Cys Ser Cys Lys Lys Asp Ser <210> 511 <:211> 21 <:212> DNA
<213> Artificial <220>
<221> Artificial Sequence <.222> 1-21 <223> Artificial Sequence <900> 511 tggagcagca atatgccagc c '21 <210> 512 <211> 22 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-22 <223> Artificial Sequence <900> 512 ttttccact:c ctgtcgggtt gg a_'2 <210> 513 <211> 46 <212> DNA
<213> Artificial <220>
<221> Artificial Sec~uenc:e <222> 1-46 <223> Art.ific.ial Sequence <400> 513 ggtgacactt gcc:agtcaga tgtggatgaa tgcagtgcta ggaggg 46 <210> 514 <211> 2690 <212> DNA
<213> Homo Sapiens <220>
<221> unsure <:222> 2039-2065 <223> unknown base <400> 514 ggttgccaca gctggtttag gg<:cccgacc ac.tggggccc cttgtcagga 50 ggagacagcc tcccggcccg gggaggacaa gtcgctgcca cctttggctg 100 ccgacgtgat tccctgggac ggtccgtttc ctgccgtcag ctgccggc:cg 150 agttgggtct ccgtgtttca ggccggctcc cccttcctgg tctcccttct 200 cccgctgggc cggtttatcg ggaggagatt gtcttccagg gctagcaatt 250 ggactttt.ga tgatgtttga ccc:ag cggca ggaatagcag gcaacgtgat 300 ttcaaagctg ggctcagcct ctcitttcttc tctcgt:gtaa tcgcaaaacc 350 cattttggag caggaattcc aar.c<~tgtct cxtgatggtgg tgagaaagaa 900 ggtgacacgg aaatgggaga aac.:tccca;gg caggaac:acc ttttgctgtg 450 atggccgcgt catgatggcc cggcaaa<=gg gcatttt:cta cctgaccctt 500 ttcctcatcc tggggacatg tacactcttc ttcgcctttg agtgccgcta 550 cctggctgtt cagctgtctc ctgccatc-cc tgtatttgct. gccatgctct 600 tccttttctc catggctaca ctgttgac:ga cc:agcttcag tgaccctgga 650 gtgattcctc gggcgctacc agatgaagca gctttcatag aaatggagat 700 agaagctacc aatggtgcgg tgccccaggg ccagcgacca ccgcctcg to 750 tcaagaattt ccagataaac aaccagattg tgaaa ctgaa atactgttac 800 acatgcaaga t.cttccggcc t=ccccggcxc:c tcccattgca gcatctgtga 850 caactgtgtg gagcgcttcg ac::atcacvtg cccctgggtg gggaattgtg 900 ttggaaagag gaactaccgc tacttctacc tcttcatcct ttctctctcc 950 35u ctcctcacaa tctatgtctt cgccttcaa~c atcgtctatg tggccctcaa 1000 atctttgaaa attggcttct tgqagacact gaaag.aaact cctggaactg 105C
tt.ctagaagt c:ctcatttgc ttctttacac tca.ggtccgt cgtgggactg 1100 actggat.tt:c atactttcct cgtggctct_c. aac.cagacaa ccaatgaaga 1150 catcaaagga tcatggacag ggaagaatcg cgtccagaat ccctacagcc 1200 atggcaatat tgtgaagaac tgctgtga:~g tgctgtgtgg ccccttgc.cc 125C
cccagtgtgc tggatcgaag gggtatttt:g cca ctggagg aaagtggaag 1300 tcgacctccc agtactcaag agaccagtag cagcctctt:g ccacagagcc 1350 cagcccccac agaacacctg aactc.aaar,g a<aatgccgga ggacagcagc 1900 actcccgaag agatgccacc tccagagccc ccagagccac cacaggaggc 1450 agctgaagct gagaagtagc ctatca atc~g aagagacttt tgtttgtgtt 1500 taattagggc tatgagagat ttcaggtgag aagttaaacc tgagacagag 1550 agcaagtaag ctgtcccttt taact:.gtttt tctttgqtc:t ttagtcaccc 1600 agttgcacac tggcattttc ttcctgcaag ct.tttttaaa tttctgaact 1650 caaggcagtg gcagaagatg tc<cgt:cacct ct:gataactg gaaaaatggg 1700 tctcttgggc cctggcactg gttct=ccot.g gcctcagcc:a cagggtcc:cc 1750 ttggaccccc tctcttccct cca=zgatccca qccctcctgc tt_ggggtcac 1800 tggtctcatt ctggggctaa aagtttttga gactggca ca aatcctcc:ca 1850 agctgctgca cgtgctgagt ccagaggcag tcacagagac ctctggccag 1900 gggatcc.taa ctgggttctt ggggtcttca ggact.gaaga ggagggac~ag 1950 tggggtcaga agattctcct ggccaccaag tgccagcatt gccc:acaaat 2000 ccttttagga atgggacagg taacttccac ttgttgtann nnnnnnnnnn 2050 nnnnnnnnnn nnnnnttgtt= ttTc~~ttt tg acacctgctc ccattaggag 2100 caggaatggc agtaataaaa gtat~3cactt tggtcat.tt:c tttt.cctcaa 2150 aggaagcccg agtgctcact taaacactat c-ccctcagac tccctgtgtg 2200 aggcctgcag aggccctgaa tgcacaaa:tg ggaaaccaag gcacagagag 2250 gctctcctct cctctcctct cccccgatqt accctcaaaa aaaaaaaaat 2300 gctaaccagt tcttccatta ag:~ctcggc:t gagtgaggga aagcccagca 2350 ctgctgccct ctcgggtaac tcaccctaag gcctcggccc acctctggct 2400 atggtaacca cactgggggc ttcctccaag ccccgct:ctt c:cagcacttc 2450 caccggcaga gtcccagagc cacttcac:cc tgggg gtggg ctgtggcccc 2500 cagtcagctc tgctcaggac ctg~otcta~.t tcagggaaga agatt=tatgt 2550 attatatgtg gctatatttc ctagagca::c tgtgtrttcc tca ttctaag 2600 ccagggtcct gtctggatga cttatgcgyt gggggagtgt aaaccggaac 2650 ttttcatcta tttgaaggcg attaaactyt. gt.ctaatgca 2f>90 <210> 515 <211> 364 <212> PRT
<213> Homo Sapiens <400> 515 Met Ser Val Met Val Val Arg Lys hys Val Thr Arg Lys Trp Glu Lys Leu Pro Gly Arg Asn Thr Phr: Cys Cys Asp Gly Arg Val Met Met Ala Arg Gln Lys Gly Ile Phe 1'yr Leu Thr Leu Phe Leu Ile Leu Gly Thr Cys Thr Leu Fhe Phe Ala Phe Glu Cys Arg Tyr Leu Ala Val Gln Leu Ser Fre Ala Ile Pro Val Phe Ala Ala Met Leu F>5 70 75 Phe Leu Phe Ser Met Ala Thr Lea Leu Arg Thr Ser Phe Ser Asp 80 85 gp Pro Gly Val Ile Pro Arg Ala Leu Fro Asp Glu Ala Ala Phe Ile Glu Met Glu Iie Glu Ala 'T'hz- Asn G'_y Ala V~~1 Pra Gln Gly Gln Arg Pro Pro Pro Arg Ile Lys Asn Fhe Gln Ile Asn Asn Gln Ile Val Lys Leu Lys Tyr C.ys 'yr Thr Cys Lys Ile Phe Arg Fro Pro Arg Ala Ser His Cys Ser lle Cys Asp Asn Cys Val Glu Arg Phe Asp His His Cys Pro Trp Va1 Gly Asn Cys Val Gly Lys Arg Asn Tyr Arg Tyr Phe Tyr Leu I'he Ire Leu Ser Leu Ser Leu Leu Thr Ile Tyr Val Phe Ala Phe Asn Ire Val Tyr Val Ala Leu Lys Ser Leu Lys Ile Gly Phe Leu Glu Ttar Leu Lys Glu Thr Pro Gl.y Thr Val Leu Glu Val Leu Ile t.'.ys Ptie Fhe Thr Leu Trp Ser Val Val Gly Leu Thr Gly Phe His T'hr Pine Leu Val Ala Leu Asn Gln Thr Thr Asn Glu Asp Ile Lys G;ly Ser Trp Thr Gly Lys Asn Ara_ Val Gin Asn Pro Tyr Ser His G7.y Asa Ile Va.1 Lys Asn Cys Cys Glu Val Leu Cys Gly Fro Leu Pro Pr:o Ser Val Leu Asp Arg Arg Gly Ile Leu Pro Leu Glu Glu Ser Gl,~ Ser Arg Pro Pro Ser Thr Gln Glu Thr Ser Ser Ser Leu Leu Pr:. Glr: Ser Pro Ala Pro Thr Glu His Leu Asn Ser Asn Glu Met Pr~.> GLu Asp Ser Ser Thr Prr Glu Giu Met Pro Fro Pro Glu Pro Pr~~ Glu Pro Pro Gln Glu Ala Ala Glu Ala Glu Lys <210> 516 <:211> 255 <212> DNA
<213> Homo Sapiens <220>
<221> unsure <'.222> 36, 38, 88, 118, 13'>, 193, 213, 222 <223> unknown base <900> 516 aaaaccctgt attttttaca atgcaaatag acaatn<~ncc tggaggtctt 50 tgaattaggt attataggga tg<~tgggctt. gatttttntt cctggaggct 100 tttggctttg gactctcnct ttcac ccaca gagcnct:tcg accatcactg 150 cccctgggtg gggaattgtg ttc~gaaagag gaactaccgc tanttctacc 200 tcttcatcct ttntcactc<: cncctcaeaa tctatgtctt cgccatcaac: 250 atcgt 255 <210> 517 <217.> 24 <212> DNA
<213> Artificial <220>
<227.> Artificial Sequence <222> i-29 <223> Artificial Sequence <900> 517 caacgtgatt tcaaagctgg gct.c 2,4 <210> 518 <211> 20 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-20 <223> Artificial Sequence <400> 518 gcctcgtatc aagaatttcc 20 <210> 519 <211> 1F
<212> DNA
<213> Artificial <:220>
<221> Artificial Sequence <222> 1-1S
<223> Artificial Sequence <400> 519 agtggaagtc gacctcc:c 18 <210> 520 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence c222> 1-29 <223> Artificial Sequence <900> 520 ctcacctgaa atctctcata gcc.c 24 <210> 521 <:211> 50 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence ~:222:> 1-50 <223> Artificial Sequence <900> 521 cgcaaaaccc attttgggag caggaattcc aatcatgtct. gtgatggtgg 50 <210> 522 <211> 1679 <212> DNA
<213> Homo sapiens <400> 522 gttgtgtcct tcagcaaaac agt.ggat~.ta aatctccttg c:acaagctt:g 50 agagcaacac aatctatcag gaaagaaaga aagaaaaaaa c:cgaacctga 100 caaaaaagaa gaaaaagaag aagaaaaaaa atcatgaaaa ccatccagcc 150 aaaaatgcac aattctatct cttgggcaat. cttca<~gggg ct.ggr_tgctc. 200 tgtgtctctt ccaaggagtg cccgtgcgc;a gcggagatgc caccttcccc 250 aaagctatgg acaacgtgac ggtccggcag ggggagagcg ccaccctcag 300 gtgcactatt gacaaccggg tcacccgggt ggcctggca a aaccgcagca 350 ccatcctcta tgctgggaat gacaagtggt gcctggatcc tcgcgtggtc 900 cttctgagca acacccaaac gcagtaca<7c at.cgagatcc agaacgtgga 950 tgtgtatgac gagggccctt acacctgcv.c ggt.gcagaca gacaaccacc 500 caaagacctc tagggtccac ctcattgt:lc aagtatctcc caaaattgta 550 gagatttctt cagatatctc cattaatgaa gggaacaata tr_agcctcac 600 ctgcatagca actggtagac cagagcctac ggttacttgg agacacatct 650 ctcccaaagc ggttggcttt gtgagtgaag acgaatactt ggaaattcag 700 ggcatcaccc gggagcagtc: aggggactac gagtgcagtg cctccaatga 750 cgtggccgcg cccgtggtac ggagagtaaa ggtcaccgtg aactatccac 800 catacatttc agaagccaag ggtacaggtg tccccgtggg acaaaagggg 850 acactgcagt gtgaagcctc agcagtcccc tcagcagaat tccagtggta 900 caaggatgac aaaagactga ttgaaggaaa gaaaggggtg aaagtggaaa 950 acagacctr_t cctctcaaaa ctcat=cttct tcaatgtct.c tgaacatgac 1000 tatgggaact acacttgcgt ggc.ctccaac aagctgggcc acaccaatgc 1050 cagcatcatg ctatttggtc caggcgccgt cagcgaggtg agcaacggca 1100 cgtcgaggag ggcaggctgc gtctggctgc tgcctcttct ggtcttgcac 1150 ctgcttctca aattttgatg tgagtgccac ttccccaccc gggaaaggct 1200 gccgccacca ccaccaccaa cacaacagca atggcaacac cgacagcaac 1250 caatcagata tatacaaatg aaattagaag aaacacagcc tcatgggaca 1300 gaaatttgag ggaggggaac aaagaatact ttggggggaa aagagtttto 1350 aaaaagaaat tgaaaattgc ctt~gcagata tttaggtaca atggagtttt 1400 cttttcccaa acgggaagaa cacagcacac ccggcatgga cccactgcaa 1450 gctgcatcgt gcaacctctt tggtgccagt gtgggcaagg gctcagcctc 1500 tctgcccaca gagtgccccc acgtggaaca ttctggagct ggccatccca 1550 aattcaatca gtccatagag acga.acactaa tgagaccttc cggcccaagc 1600 gtggcgctgc gggcactttg gtagactgtg ccaccacggc gtgtgttgtg 1650 aaacgtgaaa taaaaagagc aaaaaaaaa 1679 <210> 52~' <211> 344 <212> PRT
<213> Home Sapiens <4~~i> 5G3 Met Lys Thr Ile Gln Pro Lys Mei His Asn Ser Ile Ser 'i'rp Ala Ile Phe Thr Gly Leu Ala Ala Leo Cys Leu E'he G1n (~ly 'Jal Pro Val Arg Ser Gly Asp Ala Thr Fhe F'ro Lys Ala Met Asp Asn Val Thr Val Arg Gln Gly Glu Ser Ala Thr Leu Arg Cys Thr Ile Asp ~; 0 5 .'; 6 0 Asn Arg Va1 Thr Arg Val Ala Trt:~ Leu Asn Arg Ser 'Chr Ile Leu 65 ;0 75 Tyr Ala Gly Asn Asp Lys Trp Cy:~ Leu Asp Pro Arg 'Jal Val Leu Leu Ser F~sr. Thr Gln Thr Gln Tyr Ser Ile Glu Ile Gln Asn Val Asp Val Tyr Asp Glu Gly Fro Tyr Thi: Cys Ser Val Gln Thr Asp Asn His Pro Lys Thr Ser P.rg Val His Leu Ile Val Gl.n Val Ser 125 i3C 135 Pro Lys Ile Val G.lu Ile S~er Ser Asp Ile Ser Ile Asn Glu Gly Asn Asn Ile Ser Leu Thr C~ys Ile Ala Thr Gly Arg Pro Glu Pro Thr Val. Thr Trp Arg His Ile Ser Pro Lys Ala Val Gly Phe Val Ser Glu Asp Glu Tyr Leu Clu Ile Gln Gly Ile Thr Arg Glu Gln Ser Gly Asp Tyr Glu Cys Ser Ala Ser Asn Asp Val Ala Ala Pro Val Val Arg Arg Val. Lys ''al Thr Val Asn Tyr Pro Pro Tyr Ile Ser Glu Ala Lys Gly Thr (~ly Val Fro Val. Gly Gln Lys Gly Thr Leu Gln Cys Glu Ala Ser Ala Val Pro Ser Ala Glu Phe Gln Trp Tyr Lys Asp Asp Ly~> Arg ,eu Ile G1u Gly Lys Lys Gl.y Val Lys Val G.lu Asn Arg Pro Phe i~eu Se:r I_~ys Leu Ile Phe Phe Asn Val Ser Glu His Asp Tyr Gly Asn Tyr Thr Cys Val Ala Ser Asn Lys 290 29'i 300 Leu G1y His Thr Asn A1a Ser Ile Met Leu Fhe Gly I'ro Giy Ala Val Ser Glu Val Sez Asn GLy Thr Ser Arg Arg Ala C,~ly ~ys Val 320 32~~ 330 Trp Leu i~eu Pro Leu Leu Val Leu His Leu Leu Leu Lys Phe 335 39 C) <2i0> '.i24 <211> 503 <212> DNA
<213> Homo sapiens <400> 529 gaaaaaaaat catgaaaacc atccagccaa aaatgcacaa tt:ctatctct 50 tgggcaatct tcacggggct ggctgctcr_g tgtctcttcc aaggagtgcc 100 cgtgcgcagc ggagatgcca ccttccccaa agctatggac aacgtgacgg 150 tccggcaggg ggagagcgcc accctcaggt gcactattga caaccgggtc 200 acccgggtgg cctggctaaa ccgcagca~c at:cctctatg ctgggaatga 250 caagtggtgc ctggatcctc gcgtggtcct ~ctgagcaac: acccaaacgc 300 agtacagcat cgagatccag aacgtggatg tgtatgacga gggcccttac 350 acctgctcgg tgcagacaga caaccaccca aagacctcta gggtccac;ct 900 cattgtgcaa gtatctccca aaattgtaga gatttcttc,a gatatctcca 450 ttaatgaagg gaacaatatt agcctcacct gcatagcaac tggtagac:ca 500 gag 503 <:210> 525 <:211> 26C2 <212> DNA
<:213> Homo sapiens <900> 525 atggctggtg acggcggggc cgggcagggg ac:cggggccg cggcccggga 50 gcgggccagc tgccgggagc ccr_gaatcac cgcctggccc gact.ccacca 100 tgaacgtcgc gctgcaggag ctgggagctg gcagcaacgt gggattccag 150 aaggggacaa gacagctgtt aggctcacgc acgcagctgg agctggtctt 200 agcaggtgcc tctctactgc tggctgca:ct g<.t.tctgggc t.gccttgtgg 250 ccctaggggt ccagtaccac agagacccat cccacagcac ctgccttaca 300 gaggcctgca ttcgagtggc tgg aaaaaztc ctggagtccc tggaccg,sgg 350 ggtgagcccc: tgtgaggact tttaccaqtt r_tcctgtggg ggctggattc 400 ggaggaaccc cctgcc:cgat ggg cgttc:tc gctggaacac cttcaacagc 450 ctctgggacc aaaaccaggc catactga~:g cacctgcttg aaaac:accac: 500 cttcaactcc aacagtgaag ctgagcagaa gacacagcgc ttctacctat 550 cttgcctaca ggtggagcgc att:4aggacxc tgggagcc:ca gccactgaga 600 gacctcattg agaagattgg tggttgga:cc attacggggc cctgggacca 650 ggacaactt.t atggaggtgt tgaaggcac~t agcagggacc tacagggcca 700 ccccattctt caccgtctac atcagtgca.-.g act.ct.aagag ttccaacagc 750 aatgttatcc aggtggacca gtctgggcrrc tttctgc:~ct ctcgggatta 800 ctacttaaac agaactgcca atgagaaa:yt gc:tcactgcc tatctggatt 850 acatggagga actggagatc~ ctgctgggtg qgcggcccac ctccacgagg 900 gagcagatgc agcaggtgct. ggagttggag atacagctgg ccaacatcac 950 agtgccccag gaccagcggc gcgacgagga gaagatctac cacaagatga 1000 gcattt.cgga gctgcaggc~. ctcgcgccca ccatggactg gcttgagttc 1050 ctgtctttc~t tgctgtcacc attggagttg agtgac:tctg agcctgtggt 1100 ggtgtatggg atggattatt:. tgcagcaggt gtcagagctc atcaaccqca 1150 cggaaccaag catcctgaac aattacct:ga tctggaacct ggtgcaaaag 1200 acaacctcaa gcctggaccg acc:ctttgag tc:tgcacaag agaagctact 1250 ggagaccctc tatggcacta agaagtcctg tgtgccgagg tggcagacct 1300 gcatctccaa cacggatgac gcccttggct rtgctttggg gtcactcttc 1350 gtgaaggcca cgtttgaccg gcaaagcaaa gaaatt<7cag aggggatgat. 1400 cagcgaaatc cggac:cc~cat ttctaggaggc: c-ctgggacag ctggtttgga 1450 tggatgagaa gacccgccag gcagccaagg agaaagc:aga tgcc:atctat 1500 gatatgattg gtttcccaga ct:ttatcctg gagcccaaag agctggatga 1550 tgtttatgac gggtacgaaa tt'ctgaaga ttctttcttc caaaacatgt 1600 tgaatttgta caacttctct gccaaggtta tggctgacca gctc;cgcaag 1650 cctcccagcc gagacc.agtg gagcatgacc ccccagacag tgaatgccta 1700 ctaccttcca actaagaatg ag,jtcgtc:tt ccccgct:ggc atc<agcagg 1750 cccccttcta tgcccgcaac ca:ccca<~gg ccctgaactt cggtggcatc 1800 ggtgtggtca tgggccatga gttgacgc:at gcctttgatg accaagggcg 1850 cgagtatgac aaagaaggga acctgcg<Icc ctgg2.ggcag aatgagtccc 1900 tggcagcctt ccggaaccac acggcctctca tggaggaaca gtacaat.caa 1950 taccaggt:.ca atggggagag gct:caacc~gc cgccagacgc tgggggagaa 2000 cattactgac aacggggggc tgaaggctgc: ctacaatgct tacaaagcat 2050 ggctgagaaa gcatggggag gag:ragcaac tgccagcc~gt ggggca cacc 2100 aaccaccagc tcttcttcgt ggg;~tttgcc c:ag gtgtggt gctcggtccg 2150 cacaccagag agctctcacg aggggctg<rt gaccgacc:cc cacagccctg 2200 cccgcttccg cgtgctgggc act;:tctcca actcccgtga cttcctgcgg 2250 cacttcggct gccctgtcgg ctcccccat.g aacccagggc agctgtgtga 2300 ggtgtggtag acctggatca ggggagaa~t ggccagctgt caccagacct 235C
ggggcagctc tcctgacaaa gctgtttgca cttgggttgg gaggaagcaa 2400 atgcaagctg ggctgggtct. agtccctcc:c ccccacaggt gacatgagta 2450 cagaccctcc tcaatcacca cattgtgc::t c_t:gctttggg ggtgcccctg 2500 cctccagcag agcccccac<~ attcactgtg acatctttcc gtgtcaccct 2550 gcctggaaga ggtctgggtg gggaggccag ttcccatagg aaggagtctg 2600 cc 2602 <210> 52 6 <211> 736 <212> PRT
<213> Homo sapiens <400> 526 Met Asn Vai. Ala Leu Gln C,lu Leu Gly Ala Gly Ser Asn Val Gly Phe Gln Lys Gly Thr Arg tln Leu Leu GIy Ser Arg Thr GLn Leu 20 % 5 30 Glu Leu Val Leu Ala Gly Ala Ser Leu Leu Leu ALa Ala Leu Leu 35 4(? 95 Leu Gly Cys Leu Val Ala :~eu Gly Val GLn Tyr His Arg Asp Pro ';0 55 60 Ser His Ser Thr C.'ys Leu Thr Glu Ala Cys Ile Arg Val Ala Gly Lys Ile Leu Glu Ser Leu .asp A_g Gly Val Ser Pro Cys Glu Asp 80 h5 90 Phe Tyr Gln Phe Ser Cys ,Gly G:iy Trp I:le Arg Arg Asn Pro Leu Pro Asp Gly Arg Ser Arg Trp Asr: Thr Phe Asn Ser Leu Trp Asp Gln Asn Gln A1a Ile Leu Lys His Leu LE:u Glu Asn Thr Thr Phe Asn Ser Ser Ser c;lu Ala Glu GLn Lys Thr Gln Arg Phe 'ryr Leu i90 195 150 Ser Cys Leu Gln Val Glu Arg Ile Glu Gl.u Leu Gly Ala Gln Pro Leu Arg Asp Leu Ile Glu Lys Ile Gly Gly 'T'rp Asn Tle 'I'hr Gly 7 70 17~, 180 Pro Trp Asp Gln Asp Asn Pne Met Gl a Val Leu Lys Ala 'Jal Ala 185 19(~ 195 Gly Thr Tyr Arg Ala Thr Pro Ph<~ Phe Thr Val Tyr Ile Ser Ala 200 20r:~ 210 Asp Ser Lys Ser Ser Asn Ser Asn Val I'e Gln Va1 Asp Gln Ser 21F~ 220 225 G1y Leu Phe Leu Pro Ser Arg Asp Tyr Tyr Leu Asn Arg Thr Ala Asn Glu Lys Val Leu Thr Al.a Tyr heu Asp Tyr Met Glu GLu Leu Gly Met Leu Leu Gl.y Gly P.rg Pro Thr Ser Thr Arg Glu Gln Met 26G 265: 270 Gln Gln 'dal Leu Gl.u Leu Glu Ile Glr~ heu Ala Asn Ile Thr Val Pro Gin Asp Gln Arg Arg Asp Glu Giu Lys Ile Tyr His Lys Met Ser Ile Ser Glu Leu Gln Ala Leu Al.a Pro Ser Met Asp Trp Leu Glu Phe Leu Ser Phe Leu Leu Ser Pro Leu Glu Leu Ser Rsp Ser Glu Fro Val Val Val Tyr c~ly Met Asp Tyr Leu Gln Gln Val Ser Glu Leu Ile Asn Arg Thr c:~lu Pro Ser Ile Leu Asn Asn Tyr Leu Ile Trp Asn Leu Vai Gln Lys TOr Thr Ser Ser Leu Asp Arg Arg Phe Glu Ser Ala C;ln Glu Lye Lc:;u Leu G'l.u Thr Leu Tyr Gly Thr Lys Lys Ser Cys Val Pro Arg Trp Gln Thr Cys Ile Ser Asn Thr Asp Asp Ala Leu Gly Phe Ala Le~u C;ly Ser Leu Phe Val. Lys Ala Thr Phe Asp Arg c;ln Ser Lys Gl.u Ile Ala Glu Gly Met I1e 5er Glu Ile Arg Thr Ala Phe Glu Giu Ala Leu Gly Gln Leu Val Trp Met Asp Glu Lys Thr Arg Gln Ala Ala Lys Glu Lys Ala Asp Ala Ile Tyr Asp Met Ile Gly Phe Fro Asp Fhe Ile Leu Glu Fro Lys Glu Leu Asp Asp Val Tyr Asp Gly Tyr Glu Ile Ser Glu Asp Ser Phe Phe Gln Asn Met Leu Asn Leu Tyr Asn Phe Ser Ala Lys Val 50~~~

Met Ala Asp Gln Leu Arg Lys Pro Pro Ser Arg Asp Gln Trp Ser Met Thr Pro Gln Thr Val Asn Ala Tyr Tyr Leu hro Thr hys Asn Glu Ile Val Phe Pro Ala Gly Ile Leu Gln ~:la I'ro Phe Tyr Ala Arg Asn His Pro Lys Ala Leu Asn Phe Gly Gly Ile Gly Val Val 560 56_'~ 570 Met Gly His G1u Leu Thr H~s Ala Phe Asp Asp c';ln Gly Arg Glu 575 5so 585 Tyr Asp Lys Glu Gly Asn Leu Arc_; Pro Trp Trp Gln Asn Glu Ser Leu Ala Ala Phe Arg Asn His Thr Ala Cys Met G1u Glu Gln Tyr Asn Gln Tyr Gln Val Asn Gly Glu Arg Leu Asn Gly Arg Gln Thr Leu Gly Glu Asn Ile Thr Asp Asn G.ly Gly heu Lys Ala Ala Tyr 635: 640 695 Asn Ala Tyr Lys Ala Trp Leu Ar~a Lys His Gly Glu Glu Gln G1n Leu Prc Ala Val Gly Leu Thr Asri I-Iis Gln Leu Phe Phe Val Gly Phe Ala Gln Val Trp Cys Ser Val Arg Thr Pro Glu Ser Ser His Glu Gly Leu Val Thr Asp fro His Ser Pro Ala Arg Phe Arg Val.

Leu G1y Thr Leu Ser Asn Ser Arg Asp Phe Leu Arg His Phe Gly 7~~0 715 720 Cys Pro Vai Gly Ser Pro ~9et Asn Fro Gly Gln Leu Cys Glu Val '725 7:0 735 Trp <210> 527 <211> 9308 <212> DNA
<213> Homo sapiens <220>
<221> unsure <222> 1978, 3978, 905'7-4058, 9!"i70 361.

~223> unknown base -4oe> 527 gcccggccct ccgccctccg cacvc~.:cgc:c tccctcc<ac cgcccgctcc 50 cgcgccotcc tccctc:c~~tc ctccccagc:t gtcccgttcg cgtcatgccg 100 agcctcccgg ccccgccg gc ccc~.~ctgctg c:tcctcgggc tgctgctgct 150 cggetcecgg ccggcecgcg geg~~cggee.c agagecce.ec gtgctgceca 200 tccgttctga gaaggagccg ctg~ccgttc ggggagcggc aggtaggtgg 250 gcgcccgggg gaggcgcggg cggggagtc;g ggctcggc~gc gagtcagcgc 300 cagcccggag ggggcgcggg gcgcaggtr~g c:tcggcgcgg cgggcggccc 350 ggagggtggg cgggggcaga agggcgcggt gcctgggacc cgggacccgc 400 gggcagccc;c cggggcggca cacggcgcc:3a gct:gggcagc ggcctccagc 450 caagcccgtc cccgcaggct gcaccttcrag cgggaaggtc tatgccttgg 500 acgagacgtg gcacccggac ctaggggac:c cattcggggt gatgcgctgc 550 gtgctgtgcg cctgcgaggc gcagtggggt cgccgtac;ca ggggccctgg 600 cagggtcaclc tgcaagaaca tcaaacca<~a gtgccc:aacc ccggcctgtg 650 ggcagccgcg ccagctgccg ggacoctgct gccagacctg cccccaggac 700 ttcgtggcgc tgctgac:agg gccgaggtcg caggcggtgg ca cgagcc:cg 750 agtctcgctg ctgcgct:cta gcctc:cgct:t ctctatctcc tacaggcggc 800 tggaccgccc taccaggatc cgcttctcag actccaatgg cagtgtcctg 850 t.ttgagcacc ctgcagcccc caccc;aagat ggcctggtct gtggggtgtg 900 gcgggcagtg cctcggttgt ctctgcggct ccttagggc:a gaacagct.gc 950 atgtggcact tgtgacactc act.caccctt caggggaggt ctgggggcct 1000 ctcatccggc accgggcc.ct gtc;cccaaag ac;cttcagtq ccatcctgac 1050 tctagaaggc ccccaccagc: agcXgcgtagg gggcatcac;c ctgctcactc 1100 tcagtgacac agaggac:tcc ttc7cattttt tgctgctctt ccgaggcc~tt 1150 gcaggactaa cccaggttcc: cttgaggotc cagattctac accaggggca 1200 gctactgcga gaacttcagg ccaatgt<:tc agcc<:aggaa ccaggctttg 1250 ctgaggtgct gcccaacctg acagtccagg agatggactg gctggtgctg 1300 ggggagctgc agatggccct ggagtggcaca ggcaggccaa ggctgcgcat 1350 cagtggacac attgctgcca ggaagagca g cgacgtc:ctg c:aaagtgtcc 1400 tttgtggggc taatgccctg at::ccagt.cc aaacgggtgc tgccggctca 1950 gccagcctca ctctgctagg aaatggcncc ctgat.cctcc aggtgcaatt 1500 ggtagggaca accagtgagg tggtggcc~;t gacactggaa accaagcctc 1550 agcggaggga tcagccca ct gtcca:gtgcc acatggctgg cctat:cctcc 1600 cctgccccca ggccgtgggt atctg~~cctg ggctggggtg cccgaggggc 1650 tcatatgctg ct.gcagaatg agctcttccvt gaacgtgqgc ac:caaggact. 1700 tcccagacgg agagcttcgg ggg;:,aacgt.g gctgccct,gc cctactgtgg 1750 ggcatagcgc ccgccctgcc cgtgcccc~a gcaggagccc tggtgctacc 1800 ccctgtgaag agccaagcag cagggcacc~c ctggcttt:cc tt;ggataccc 1850 actgtcacct gcactatgaa gtgctgctrag ctgggctt:.gg tggctcagaa 1900 caaggcact;g tcactgccca cct.ccttgc~g cct.cctggaa cgccagggcc 1950 tcggcggctg ctgaagggat tctatggctc agaggcccag ggtgtggtga 2000 aggacctgga gccggaactg ctgcggcac:c tggcaaaagg catggcttcc 2050 ctgatgatca ccaccaaggt agc.cccagag gggagctccg agggcagcct 2100 ctcctcccag gtgcacatag ccaaccaat:g tgaggttggc ggactgcocc 2150 tggagqcggc cggggcc:gag ggggtgcggg cgctgggggc t~..cggataca 2200 gcctctgctg cgccgcctgt ggtgcctggt c-tcccggccc tagcgcccgc 2250 caaacctggt ggtcctqggc ggc.cc:cgaga c:cccaacaca tgcttctt.cg 2300 aggggcagca gcgcccccac ggggctcgct gggcgcccaa ctacgacccg 2350 ctctgct.cac tctgcac:ctg ccagagacga ac:ggtgatct gtgacccggt 2900 ggtgtgccca ccgcccagct gcccacaccc ggtgc:aggct cccgaccagt 2950 gctgccctgt ttgccctggr_. tgcaattttg atggt.gaccg gagctggcgg 2500 gcagcgggta cgcggtggca ccc:cgttqtg crcccctttg gctt.aat,~_aa 2550 gtgtgctgtc: tgcacctgca agc:agggggg cactggagag gtgcactgtg 2600 agaaggtgca gtgtccccgg ctggcctgtg cccagcctgt gcgtgtcaac 2650 cccaccgact gctgcaaaca gtgtccaggt gagg<:ccacc c:ccagctggg 2700 ggaccccatg caggctgatg ggccccgggg ctgccgtttt gctgggcagt 2750 ggttcccaga gagtcagagc tggcaccc:ct cagtgccccc gtttggagag 2800 atgagctgta tcacct.gcag atqtgggqta agtgg ggagc agaggcttgt 2850 gtgaggtggg tactgggagc ctggtctgga gtagggagac cttcccaggg 2900 aggtccctga agaagctgaa ggtcactqt.g tccc,sgtgcc t=ctgggggac 2950 actcagtgtc tgctctgtct tgtaccaggc aggggtgcct cactgtgagc 3000 gggatgactg ttcactgcca ctgtcctgtg gctcggggaa ggagagtcga 3050 tgctgttccc gctgcacggc ccaccggc;g g cgtaagtgag ggagtccagg 3100 gtcagcagct gtgagtggag ggctcacctg cctgtgggac tcctgatcag 3150 agaagggagc actc:actgtg tgc«ggaaca gtgcagcctg c:ctcacaagt 3200 gccattccaa tccaccctca cagcaacctg gtggaattgt tatttatgac 3250 cttttcttt:a caaatgagat ttct:gaagct cagagaaatt: aagcaacgag 3300 atgaaggtca cccagctgtg tgcactgacc tgtttagaaa atactggcct 3350 ttctgggacc aaggcaggga tgcrtrgcc:c tgccct:c:t:at gc:ctctctgt 3900 gcctctccac tccctctccc ctcctccaac attccctccc ttctqtctc::c 3950 agcagcccca gagaccagaa ctg<itccaga gctggagaaa gaagccgaag 3500 gctcttaggg agcagccaga ggg~~caagig accaagagga tggggcctga 3550 gctggggaag gggtggcatc gaggaccttc ttgcattc~tc ct.gtgggaag 3600 cccagtgcct ttgctcctct gtcctgcc? c: tactcccacc cc:cactacct 3650 ctgggaacca cagctccaca agggggagag gcagctgggc cagaccgagg 3700 tcacagccac tccaagtcct gcc::t,gccac cctc:ggcctc tgtcctggaa 3750 gccccacccc tttcttcctg tacataatgt cactggcttg ttgggatttt. 3800 taatttatct tcactcagca ccaagggc ,c <:qgacact:cc actcctgctg 3850 cccctgagct gagcagagtc attattggag agttttgtat ttattaaaac 3900 atttctttit cagtctttgg gcatgaggtt ggctctttgt ggccaggaac 3950 ctgagtgggg cctggtggag aaggggcnga gagtaggagg tgagagagag 9000 gagctctgac acttggggag ctgaaagaga cctggagagg cagaggatag 4050 cgtggcnntt ggctggc:atn cctgggttcc gcagaggggc tggggatggt 4100 tcttgagatg gtctagagac tcaagaattt agggaagtag aagcaggatt 4150 ttgactcaag tttagtttcc cacatcgctg gc:ctgtttgc tgacttcatg 9200 tttgaagttg ctccagagag agaatcaaag gtgtcaccag cccctctc:tc 9250 cctccttccc ttcccti::ccc ttt.cl:ttc <;c t cccca<cr_.c t.cccctcc:cc 4300 tCCCCtCC 938 <210> 528 <211> 1285 <212> DNA
<213> Homo sapiens <900> 528 ggccgagcgg gggtgctgcg cggcggcegt gatggctggt gacggcgggg 50 ccgggcaggg gaccggggcc gcggcccggg agcgggccag ctgccgggag 100 ccctgaat.ca ccgcctggcc cgactcca cc atgaacgtcg cgctgcagga 150 gctgggagct ggcagcaacg tgggattcca gaaggggaca agacagctgt. 200 taggctcacg cacgcagctg gagca ggtct tagcaggtgc ca ctctactg 250 ca ggctgcac tgcttctggg ctg<:ct:tgtg gccctagggg t:ccagtacca 300 cagagaccca tcccacagca cctqcctta~ agaggcctgc attcaagtgg 350 ctggaaaaat cctggagtcc ctggaccgag gggtgagccc ca gtgaggac 400 ttttaccagt tctcctgtgg gggcaggat t cggaggaacc <:cctgcccc~a 450 tgggcgttct cgctggaaca ccttcaaca.g cctctgggac raaaaccagg 500 ccatactgaa gcacctgctt. gaaaacacc-a crttc~aac-tc a:agcagtgaa 550 gctgagcaga agacacagcg cttctaccta tcttgcctac aggtggagcg 600 cattgaggag ctgggagccc agccactgag agacctcatt gagaagattg 650 gtggttggaa cattacgggg ccctgggac;c aggacaactt tatggaggtg 700 ttgaaggcag tagcagggac ctacagggcc accccatt:ct tcaccgtcta 750 catcagtgcc gactctaaga gttccaaca~g caatgttatc caggt:ggacc 800 agtctgggct ctttctgccc tct~gggat_t actacttaaa c<~gaactgcc 850 aatgagaaag taaggaacat. cttccgaac;c rc:catccc:t:a cccctggctg 900 agctgggctg atccctgttg acttttcc~a ttgccaaggg t~~agagcagg 950 gaaggtgagc ctatcctgtc: acctagtgaa caaactgccc ctcctttctt 1000 tCttCttttC ttCCtCCCtC: CCtCCCtttC t.tCCCCtttt CCttCCti.CC lOSO
ttcctcttat tcttctagta ggtr_tcatag acaccta~,tg tgtgccaggt 1100 ccagtggggg aattcggaga tataagtttc cgagccatt:g ccacaggaag 1150 cgttcagtgt cgatgggttc atagacctag ataggctgat aacaaagctc 1200 acaagagggt cctgaggatt caggagagac ttatggagcc agcaaagtct 1250 tcctgaagag attgcatttg agc:caggt~cc tgtag 1285 <210> 529 <211> 1380 <212> DNA
<213> Homo Sapiens <:400> 529 atgcctacta ccttccaact aagaatgaga tcgtcttccc cgctggcatc 50 ctgcaggccc ccttctatgc ccgcaacc:ac cccaaggccc tgaacttcgg 100 tggcatcggt gtggtcatgg gccatgaqtt gacgcatgcc tttgatgacc 150 aagggcgcga gtatgacaaa gaagggaacc tgcggccctg gtggcagaat 20C
gagtccctgg cagccttccg gaaccacacg gcctgcatgg aggaacagt.a 250 caatcaatac caggtcaatg gggagagg ct caacggccgc cagacgctgg 300 gggagaacat: tgctgacaac ggggggctga aggctgccta caatgcttac 350 aaagcatggc tgagaaagca tggggaggag cagcaactgc c.~agccgtggg 400 gctcaccaac caccagctct tcttcgtggg at:t:tgcccag gtgtggtgct 450 cggtccgcac accagagagc tc:.tc;acgarg ggc:tggtgac c;gacccccac 500 agccctgccc gcttccgcgt gctclggcact ctctccaact c;ccgt.gactt 550 cctgcggcac ttcggctgcc ctqtcggct.c ccccatgaac ccagggcagc 600 tgtgtgaggt gt.ggtagacc tggatcag<.tg gagaaatggc cagctgtcac 650 cagacctggg gcagctctcc tgacaaagc;t gtttgctctt gggtt:gggag 700 gaagcaaatg caagctgggc tgggtctactt cc.-ctcccccc cacaclgtgac 750 atgagtacag accctcctca atc,accac,t tgt.grct~:tg ctttgggggt 800 gcccctgcct ccagcagagc ccccaccar.t cac;tgtgaca tctttccgtg 850 tcaccctgc:c tggaagaggt ctgggtggc~g aggccagttc ccataggoag 900 gagtctgcct cttctgt.ccc caggctca.,t cagcctggcg g~~catggggc 950 ctgccgtgcc tgccccactg tg<:cccacag gcctgggtgg tgtacctc:ct 1000 ggacttctcc ccaggctcac tca.~gt:gcgca <;ttaggggtg gactcagc;tc 1050 tgtctggctc accctc<3cgg gct.accccca c;ctcaccctg tgctcctt:gt 1100 gccactgctc ccagtgc:tgc tgctgacctt cactgac:agc tcctagtqga 1150 agcccaaggg cctctgaaag cctcctgctg cccactgttt ccctgggc.tg 1200 agaggggaag tgcatatgtg tagcgggtac tggttcctgt gtcttagggc 1250 acaagcctta gcaaatgatt gattctcc:ct. ggacaaagca ggaaagcaga 1300 tagagcaggg aaaaggaaga ac.~gagttta tttttacaga aaaqagggtg 1350 ggagggtqtg gtcttggccc ttataggacc 1380 <210> 530 <211> 39 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-39 <223> Artificial Sequence <400> 530 gaagcagtgc agccagcagt agagaggcac ctgctaaga 39 <210> 531 <211> 24 <212> DNA
<213> Artificial <220>
<221> Arti.fic.ial Sequence <222> 1-24 <223> Artificial Sequence <900> 531 acgcagctgg agctggtctt agca 24 <210> 532 <211> 24 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-24 <223> Artificial Sequence <400> 532 ggt.actggac ccctagggcc acaa 29 <210> 533 <211> 21 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-21 <223> Artificial Sequence <900> 533 cctcccagcc gagaccagtg g 71 <210> 539 <21i> 21 <212> DNA
<213> Artificial <220>
~:221> Artificial Sequence <222> 1-21 <223> Artificial Sequence <900> 534 ggtcctataa gggccaagac c a1 <210> 535 <211> 44 <212> DNA
<213> Artificial <220>
<221> Artificial Sequence <222> 1-99 <223> Art-ificial Sequence <900> 535 gactagttct agatcgcgag cggccgccct tttttttttt tttt 49 <210> 536 <211> 16 <212> DNA

<213> Artificial <220>

<221>Artificial Sequence <222>1-16 <223>Artificial Sequence <400>536 cggacgcgtg ggtcga <210>53'1 <211>21 <212>DNA

<213>Artificial <220>

<221>Artificial Sequence <222>1-21 <223>Artificial Sequence <900>53i cggccgtgat ggctggtgac g 2.i <210>538 <211>20 <212>DNA

<213>Artificial <220>

<-221>Artificial Sequence <:222>1-20 <223>Artificial Sequence <400>538 ggcagactcc ttcctatggg DE1~IANDES OU BREVETS VOLUMINEUX
LA PRESENTE PARTIE DE CETTE DEyLaNDE OU CE BREVETS
CO~IPREND PLUS D'UN TOME.
CECI EST LE TOME ~ DE~
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Claims (25)

1. Isolated nucleic acid having at least 80% sequence identity to a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence shown in Figure 45 (SEQ ID NO:119).

2. The nucleic acid of Claim 1, wherein said nucleotide sequence comprises the nucleotide sequence shown in Figure 44 (SEQ ID NO:118).

3. The nucleic acid of Claim 1 or Claim 2, wherein said nucleotide sequence comprises the full-length coding sequence from within the sequence shown in Figure 44 (SEQ ID
NO:118).

4. The nucleic acid of Claim 1 which comprises the full-length coding sequence of the DNA deposited under accession number ATCC 209670.

5. Isolated nucleic acid having a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence shown in Figure 45 (SEQ ID NO:119).

6. The nucleic acid of Claim 5, wherein said nucleotide sequence comprises the nucleotide sequence shown in Figure 44 (SEQ ID NO:118).

7. The nucleic acid of Claim 5 or Claim 6, wherein said nucleotide sequence comprises the full-length coding sequence from within the sequence shown in Figure 44 (SEQ ID
NO:118).

8. The nucleic acid of Claim 5 which comprises the full-length coding sequence of the DNA deposited under accession number ATCC 209670.

9. A vector comprising the nucleic acid of any one of claims Claim 1 to 8.

10. The vector of Claim 9 wherein said nucleic acid is operably linked to control sequences recognized by a host cell transformed with the vector.

11. A host cell comprising the vector of Claim 9 or Claim 10.

12 The host cell of Claim 11 wherein said cell is a CHO cell, an E. coli or a yeast cell.

13. A process for producing a polypeptide comprising culturing the host cell of Claim 11 or Claim 12 under conditions suitable for expression of said polypeptide and recovering said polypeptide from the cell culture.

14. Isolated polypeptide comprising a sequence having at least 80% sequence identity to the amino acid sequence shown in Figure 45 (SEQ ID NO:119).

15. Isolated polypeptide comprising a sequence having at least 80% sequence identity to the amino acid sequence encoded by the nucleotide deposited under accession number ATCC
209670.

16. Isolated polypeptide comprising a sequence having the amino acid sequence shown in Figure 45 (SEQ ID NO:119).

17. Isolated polypeptide comprising a sequence having the amino acid sequence encoded by the nucleotide deposited under accession number ATCC 209670.

18. A chimeric molecule comprising a polypeptide according to any one of Claims 14 to 17, fused to a heterologous amino acid sequence.

19. The chimeric molecule of Claim 18 wherein said heterologous amino acid sequence is an epitope tag sequence.

20. The chimeric molecule of Claim 18 wherein said heterologous amino acid sequence is a Fc region of an immunoglobulin.

21. An antibody which specifically binds to a polypeptide according to any one of Claims 14 to 17.

22. The antibody of Claim 21 wherein said antibody is a humanised antibody.

23. The antibody of Claim 21 wherein said antibody is a monoclonal antibody.

24. The antibody of Claim 23 wherein said antibody is a chimeric antibody.

25 A composition comprising an antibody according to any one of Claims 21 to inadmixture with a pharmaceutically acceptable carrier.