KR101653131B1 - Composition or Kit and Method for predicting prognosis of liver cancer - Google Patents

Abstract

The present invention provides a marker for prognosis of liver cancer prognosis, a composition or kit for predicting prognosis of liver cancer, preferably a composition or kit for predicting prognosis of liver cancer for predicting prognosis by liver cancer stage, and a method for predicting prognosis of liver cancer. The marker, composition or kit or method of the present invention is effective in predicting the prognosis of liver cancer, preferably the prediction of prognosis of stage cancer.

Description

Composition or kit and method for predicting prognosis of liver cancer {Composition or Kit and Method for predicting prognosis of liver cancer}

The present invention relates to a biomarker for predicting liver cancer prognosis, and more particularly, to a composition or kit for predicting liver cancer prognosis, and a method for predicting liver cancer prognosis.

Liver cancer is known as one of the deadliest cancers in the world, and it is reported that more than 500,000 people die of liver cancer every year, especially in Asia and sub-Saharan Africa. Liver cancer can be largely divided into primary liver cancer (hepatocellular carcinoma) arising from the hepatocytes themselves and metastatic liver cancer in which cancers of other tissues have metastasized to the liver.Over 90% of liver cancers are primary liver cancer, and commonly referred to as liver cancer. It is understood to refer to primary liver cancer.

The prognosis of liver cancer refers to predicting various conditions of a patient according to liver cancer, such as the likelihood of cure of liver cancer after diagnosis of liver cancer, the possibility of recurrence after treatment, and the patient's viability. This is the severity of the disease, the time of diagnosis, and the like. It depends on various conditions such as the course of treatment. Liver cancer can be effectively treated only when various treatment methods are appropriately applied according to its prognosis. For example, for patients predicted to have a good prognosis, it is necessary to avoid dangerous treatment methods that may cause serious side effects to the patient, such as aggressive chemotherapy, surgery, and radiation treatment, and are relatively moderate and conservative. And you should choose a safe treatment method. Conversely, for patients predicted to have poor prognosis, it is necessary to actively mobilize treatment methods such as chemotherapy, surgery, and radiation to increase the duration or probability of survival.

According to the studies to date, liver cancer that has already advanced has a very poor prognosis and dies within 6 months after diagnosis and has a high fatality rate with an average survival period of only 4 months, whereas small liver cancer with a size of less than 3 cm has a prognosis. It is known that the probability of surviving one year without special treatment is 90%, and the 5-year survival rate is about 40-50% when surgery is performed. However, it is very difficult to accurately predict the prognosis of a liver cancer patient with conventional techniques. To accurately predict the prognosis, an analysis method that classifies patients by risk group is necessary. Until now, the prognosis is determined based only on the clinical pathological stage of liver cancer and primary surgical treatment at the time of diagnosis without a means to accurately predict the prognosis of liver cancer. There is a situation.

Among them, there is a BCLC (Barcelona-Clinic Liver Cancer) stage classification, and the classification is liver cancer for the purpose of determining treatment (stage-specific liver resection, liver transplant, or radiofrequency fever treatment, etc.) through preoperative stage determination of liver cancer patients. It is a patient classification method (Llovert JM, Bru C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification. Semin Liver Dis. 1999;19(3):329-338).

However, unfortunately, only the stage of liver cancer cannot accurately determine the prognosis for each liver cancer patient. Therefore, it is necessary to develop a technology using genetic markers to accurately predict the prognosis for liver cancer patients. In other words, according to the individual patient's stage and prognostic results, patients who are expected to have good results in specific treatments (e.g., hepatic resection) are selected and performed to improve the overall treatment performance of liver cancer patients as well as to reduce medical expenses, etc. Socioeconomic effects can be expected.

Meanwhile, UVRAG, NAMPT, STAT3, CIAP2, BHLHE41, MMP2, SESN2, HMGB1, SIRT1, RPS19BP1, LAMP2, AGER, SESN3, ID2, TCF3, HMGB2, TP63, RAGE, KIAA1967, SATB1, RAPTOR, SESN1, CCGNG2, and CCNG2. , CASP3, BECN1, CDH2, TWIST1, MMP9, VEGF, ATG12, DIABLO, E2F1,LAMP1, LC3, ATG7, TKT, AIFM1, BNIP3, ATG3, DRAM, ATG5, NNMT, PRKAA1, CASP8, ULK1, BCL2L1 , FRAP1, AKT1, BAX, BCL2, PTEN, CBS, XIAP proteins are not known how the expression levels or expression patterns change in liver cancer tissues by stage, and how they can be utilized by stage in predicting the prognosis of liver cancer. Until now, the protein or some of the genes encoding the protein has been used as a prognostic marker for liver cancer, but there has not been a case in which the protein or genes encoding the protein have been used as a prognostic marker for liver cancer by stage.

The present inventors have completed the present invention by knowing a gene whose expression level and expression pattern are significantly changed (by stage) as a result of a study for predicting the prognosis of liver cancer.

One technical problem to be solved in the present invention is to provide a biomarker for predicting prognosis of liver cancer that can predict the prognosis (by stage).

Another technical problem to be solved in the present invention is to provide a composition or kit for predicting the prognosis of liver cancer capable of predicting the prognosis (by stage).

Another technical problem to be solved in the present invention is to provide a method for predicting prognosis of liver cancer capable of predicting the prognosis (by stage).

The present invention provides one or more biomarkers for predicting liver cancer prognosis selected from the genes and proteins encoded by the genes shown in Table 1 below, preferably biomarkers for predicting liver cancer prognosis by stage.

[Table 1]

In the above table, NCBI GI (Geninfo Identiters) is a sequence number assigned by the National Center for Biotechnology Information (NCBI), and consists of an accession number and a version number.

In the present invention, liver cancer includes primary liver cancer (hepatocellular carcinoma) arising from hepatocytes themselves and metastatic liver cancer in which cancers of other tissues have been metastasized to the liver, and preferably refers to primary liver cancer.

In the present invention, the marker for predicting the prognosis of liver cancer refers to a genetic marker that is a criterion for predicting the prognosis after the onset of liver cancer. The marker has a significantly low probability value (p-value, p value) calculated based on the difference in expression in liver cancer cells and/or tissues of patients with different prognosis, preferably the probability value (p-value, p value) is less than 0.05.

In addition, the present invention includes a nucleic acid specific for each of one or two or more genes selected from the group shown in Table 1, or an antibody specific for the protein encoded by the gene, and group A1 {BCLC (Barcelona-Clinic Liver Cancer ) Patients with stage 0 or A according to stage classification, with tumor size less than 5 cm alone or less than 3 cm and less than 3 tumors and portal vein invasion negative}, Group A2 {with tumor size greater than 5 cm and portal invasion (portal vein invasion) negative patient group}, B group {intermediate stage patient according to BCLC stage classification, ascites tumor size exceeding 3cm or ascites tumor number exceeding 3, and portal vein invasion negative Provides a composition or kit for predicting liver cancer prognosis for predicting the prognosis for each stage of liver cancer in at least one group selected from the group of patients} or C {regardless of the size and number of cancers, patients with positive portal vein invasion}. .

The two or more genes may be three, four, five, six, seven, or eight or more genes.

Preferably, the group consisting of the genes may be a group consisting of the genes shown in Table 2 below.

[Table 2]

More preferably, the group consisting of the genes may further include the genes shown in Table 3 below.

[Table 3]

Among the genes listed in Table 2, CDH1, ID2, MMP9, and TCF3 may be excluded from Table 2, and may be additionally included in the gene group of Table 3.

The BCLC classification is the classification described in FIG. 1 and is a classification method for liver cancer patients for the purpose of determining treatment (stage hepatic resection, liver transplant, or high frequency fever treatment, etc.) through preoperative stage determination of liver cancer patients (Llovert JM, Bru C, Bruix J. Prognosis of hepatocellular carcinoma: the BCLC staging classification.Semin Liver Dis. 1999;19(3):329-338). In Fig. 1, the performance status test (PST) is classified into stages 0 to 4, and stage 0 is a case where there is no restriction on activity, stage 1 can perform a light schedule, stage 2 cannot work, but , If you can take care of yourself by yourself, step 3 can take care of yourself with a limited amount, and if you have to lie down or sit in a chair for more than 50% of your daily time, step 4 is completely incapable of activity, and you can take care of yourself. It refers to a patient who is absent, lying down or sitting and living. The Okuda stage is staged based on four items, whether the size of the cancer is larger or smaller than 50% of the total liver, whether there is ascites, bilirubin (< or> 3mg/dL), albumin (< or> 3g/). dL) is classified into I, II, III, and the Child-Pugh stage is an index to evaluate liver function in patients with cirrhosis, and albumin level (>3.5g.dL: 1 point, 2.8-3.5g/ dL: 2 points, <2.8g/dL: 3 points), jaundice (bilirubin) level (< 2.0mg/dL: 1 point, 2.0-3.0mg/dL: 2 points,> 3.0mg/dL: 3 points), Blood clotting (prothrombin time) level (>50%: 1 point, 40-50% 2 points, <40%: 3 points), ascites (none: 1 point, slight): 2 points, Moderate: 3 points), encephalopathy stage (none): 1 point, unstable personality change, depression, trembling, drowsiness, speechlessness and slowness, inability to fix posture, difficulty walking: 2 Points, muscle stiffness, loss of intellect, confusion, intermittent muscle spasms, concussion, coma, enlarged pupils, brain-brain posture: 3 points). B-level (class B), 10 points or higher are classified as C-level (class C).

The prognosis may be recurrence, survival, or disease-free survival, and the prognosis may be a prognosis after resection of liver cancer. The recurrence means that liver cancer recurs during survival after resection of liver cancer, and the survival means a 5-year survival rate after resection of liver cancer, and the disease-free survival means survival without recurrence after resection of liver cancer.

Preferably, the composition or kit is for predicting the recurrence prognosis of the group A1, and the gene may be at least one selected from the genes or gene groups shown in Table 4 below.

[Table 4]

Preferably, the composition or kit is for predicting the survival prognosis of the group A1, and the gene may be at least one selected from the genes or gene groups shown in Table 5 below.

[Table 5]

Preferably, the composition or kit is for predicting the disease-free survival prognosis of the A1 group, and the gene may be at least one selected from the genes or gene groups shown in Table 6 below.

[Table 6]

Preferably, the composition or kit is for predicting the recurrence prognosis of the A2 group, and the gene may be at least one selected from the genes or gene groups shown in Table 7 below.

[Table 7]

Preferably, the composition or kit is for predicting the survival prognosis of the A2 group, and the gene may be at least one selected from the genes or gene groups shown in Table 8 below.

[Table 8]

Preferably, the composition or kit is for predicting the disease-free survival prognosis of the A2 group, and the gene may be at least one selected from the genes or gene groups shown in Table 9 below.

[Table 9]

Preferably, the composition or kit is for predicting the recurrence prognosis of the group B, and the gene may be at least one selected from the genes or gene groups shown in Table 10 below.

[Table 10]

Preferably, the composition or kit is for predicting the survival prognosis of the group B, and the gene may be at least one selected from the genes or gene groups shown in Table 11 below.

[Table 11]

Preferably, the composition or kit is for predicting the disease-free survival prognosis of the group B, and the gene may be at least one selected from the genes or gene groups shown in Table 12 below.

[Table 12]

Preferably, the composition or kit is for predicting the recurrence prognosis of the group C, and the gene may be at least one selected from the genes or gene groups shown in Table 13 below.

[Table 13]

Preferably, the composition or kit is for predicting the survival prognosis of the group C, and the gene may be at least one selected from the genes or gene groups shown in Table 14 below.

[Table 14]

Preferably, the composition or kit is for predicting the disease-free survival prognosis of the group C, and the gene may be at least one selected from the genes or gene groups shown in Table 15 below.

[Table 15]

The nucleic acid included in the composition or kit of the present invention may be a primer or a probe.

The nucleic acid has a sequence complementary to a gene such as DNA and/or RNA, or can be hybridized.

The primer refers to a nucleic acid sequence having a free 3'hydroxyl group capable of complementarily binding to a template and allowing reverse transcriptase or DNA polymerase to initiate the replication of the template. . The primer is a nucleotide having a sequence complementary to the nucleic acid sequence of a specific gene, and has a length of about 7 bp to 50 bp, preferably about 10 bp to 30 bp. The primer may contain additional other nucleotide sequences that do not change the basic properties of the primer serving as an initiation point for DNA synthesis. Primers can be chemically synthesized using well-known methods, and such nucleic acid sequences can also be modified using a number of means known in the art.

The probe is a nucleic acid strand that is partially or completely complementary to the target nucleic acid, and is an oligonucleotide capable of binding to the target nucleic acid in a base-specific manner. Preferably, it is an oligonucleotide that is completely complementary to the target nucleic acid. The probe includes a nucleic acid as well as any known nucleic acid derivative capable of complementary binding including a peptide nucleic acid. The binding of the probe and the target nucleic acid (generally, also referred to as hybridization) is sequence-dependent and can be performed under various conditions. In general, the hybridization reaction takes place at a temperature of about 5° C. below the Tm for a particular sequence at a particular ionic strength and pH. The Tm refers to a state in which 50% of the probes complementary to the target sequence are bound to the target sequence. Examples of hybridization reaction conditions may be pH 7.0 to 8.3, 0.01 to 1.0M Na + ion concentration. In addition, in order to increase the specificity of the target nucleic acid and the probe, conditions that destabilize the binding of the target nucleic acid and the probe, such as high temperature, and the presence of a high concentration of destabilizing agent (eg formamide), etc. I can. The length of the probe is capable of sequence-specific binding to the target nucleic acid, and includes polynucleotides of any length. For example, the length of the probe may be 10 to 200 nucleotides, 10 to 150 nucleotides, 10 to 100 nucleotides, 10 to 50 nucleotides, or a length of one strand of a full-length gene, but is not limited to these examples. The probe may be labeled with a detectable label. The detectable label is SYBR Green I or a variety of probes (TaqMan Probe) at the 5'-end of the fluorescent material FAM, the 3'-end is labeled with a quencher TAMRA, but is not limited thereto. Fluorescent labels such as Cy3 or Cy5, radioactive material labels, and enzymes for converting substrates to color developing materials are included, but are not limited to these examples. In the kit of the present invention, the probe or probe set may be immobilized on a microarray.

The target nucleic acid in the sample is hybridized with the probe in the microarray, and the presence and concentration thereof can be determined by measuring the hybridization result. During the hybridization process, the target nucleic acid may be labeled with a detectable label.

The antibody refers to a protein capable of specifically binding to an antigenic epitope, and includes polyclonal antibodies, monoclonal antibodies, and recombinant antibodies. The antibody can be easily prepared using techniques well known in the art. Specifically, the polyclonal antibody can be produced by a method well known in the art in which a protein antigen encoded by a marker gene of the present invention is injected into an animal and blood is collected from the animal to obtain serum containing the antibody. Such polyclonal antibodies can be prepared from various animal species hosts such as goat, rabbit, sheep, monkey, horse, pig, cow, and dog.

The monoclonal antibody is a hybridoma method well known in the art (see Kohler and Milstein (1976) European Jounral of Immunology 6:511-519), or a phage antibody library (Clackson et al, Nature, 352 :624-628, 1991; Marks et al, J. Mol. Biol., 222:58, 1-597, 1991).

Typically, the hybridoma method uses cells from an immunologically suitable host animal such as a mouse injected with a protein antigen encoded by the liver cancer prognostic marker of the first aspect of the present invention, and the other population is cancer or myeloma. Use a cell line. These two populations of tissues are fused by methods well known in the art, such as polyethylene glycol, and then antibody-producing cells are proliferated by standard tissue culture methods. After obtaining a homogeneous cell population by subcloning by a limited dilution technique, hybridomas capable of producing a desired antibody are cultured in large quantities in vitro or in vivo according to a known technique. The phage antibody library method is a method of producing an antibody library in vitro by obtaining a gene of a desired antibody and expressing it in the form of a fusion protein on the surface of the phage, and isolating a desired monoclonal antibody from this library to produce a monoclonal antibody. . The monoclonal antibody prepared by the above method can be isolated using known methods such as gel electrophoresis, dialysis, salt precipitation, ion exchange chromatography, and affinity chromatography.

The antibody comprises a complete form having two full-length light chains and two full-length heavy chains, as well as functional fragments of antibody molecules. A functional fragment of an antibody molecule refers to a fragment that has an antigen-binding function, and includes Fab, F(ab'), F(ab')2, and Fv.

The prediction of the liver cancer prognosis may be a prediction of a prognosis before or after a liver cancer resection.

In addition to the nucleic acid or antibody, the kit may further include one or more other components, solutions, or devices suitable for the method of analyzing the amount of gene expression, the amount of gene expression, or the expression pattern, or the method of analyzing the amount of protein abundance or presence pattern. . For example, when the diagnostic kit is a kit for detecting the expression level or expression pattern of a gene, the diagnostic kit may be a diagnostic kit including essential components necessary for performing RT-PCR, and such RT- In addition to the respective primers specific for the mRNA of the marker gene, the PCR kit can be, depending on the specific implementation, for example, a test tube or other suitable container, reaction buffer, deoxynucleotides (dNTPs), enzymes such as Taq-polymerase and reverse transcriptase. , DNase, RNase inhibitor DEPC-water, sterile water, a primer pair specific to a gene used as a quantitative control, and the like may be included. On the other hand, when the kit is a diagnostic kit for detecting the abundance or presence pattern of a protein, the diagnostic kit may be, for example, a diagnostic kit including essential components necessary for performing ELISA, and such an ELISA kit Components capable of detecting bound antibodies, such as labeled secondary antibodies, chromopores, enzymes (e.g., enzymes conjugated with antibodies) and substrates thereof, and antibodies specific for a quantitative control protein, etc. It may include. In addition, according to a specific embodiment, the kit may include a DNA microarray or a protein microarray.

In addition, the present invention is a nucleic acid specific to each of one or two or more genes selected from the group described in Table 2 (described in the composition or kit for predicting liver cancer prognosis for predicting the prognosis of each liver cancer stage of the present invention), or the gene is It provides a composition or kit for predicting the prognosis of liver cancer, including an antibody specific for the encoding protein.

The group may be a composition or kit further comprising a gene described in Table 3 (described in the composition or kit for predicting liver cancer prognosis for predicting the prognosis of each liver cancer stage of the present invention).

Matters mentioned in the composition or kit for predicting liver cancer prognosis for predicting the prognosis for each stage of liver cancer of the present invention are equally applied to the composition or kit unless contradictory.

In addition, the present invention is one selected from the group consisting of (A) the genes listed in Table 1 among samples collected from liver cancer patients (described in the composition or kit for predicting liver cancer prognosis for predicting the prognosis of each liver cancer stage of the present invention) or Measuring at least one selected from two or more gene expression levels or expression patterns; And (B) predicting the prognosis of liver cancer by comparing the measured value of step (A) with a reference value, wherein the liver cancer patients are classified as 0 or A stage according to BCLC (Barcelona-Clinic Liver Cancer) stage classification. , Tumor size 5 cm or less alone or 3 cm or less and portal vein invasion negative patient group}, A2 group (tumor size greater than 5 cm tumor size and portal vein invasion negative patient group}, Group B {patients with intermediate stage according to BCLC stage classification, ascites tumors with a tumor size of more than 3 cm or ascites tumors with a tumor number of more than 3 and negative portal vein invasion}, or group C {cancer Regardless of the size and number, a method for predicting the prognosis of liver cancer for each stage of liver cancer belonging to one or more groups selected from among patients with positive portal vein invasion} is provided.

Preferably, the group consisting of the genes may be a group consisting of the genes described in Table 2 (described in the composition or kit for predicting liver cancer prognosis for predicting the prognosis of each liver cancer stage of the present invention), and the group consisting of the genes is shown in Table 2 The gene described in 3 (described in the composition or kit for predicting liver cancer prognosis for predicting the prognosis for each liver cancer stage of the present invention) may be further included.

The sample collected from the liver cancer patient refers to cells or tissues isolated from the human body capable of detecting the expression level or expression pattern of the liver cancer prognostic marker, or the abundance or presence pattern of the protein encoded by the liver cancer prognostic marker. , Blood, plasma, serum, and the like may be exemplified, but are not particularly limited thereto. The tissue may be embedded in a paraffin block.

The gene expression level or expression pattern can be detected by a conventional biochemical analysis method for confirming the amount or pattern of mRNA generated by transcription of the corresponding gene. Analysis methods for confirming the amount or pattern of these mRNAs include RT-PCR, competitive RT-PCR, real-time RT-PCR, and RNase protection assay. , Northern blot, DNA microarray, etc., in addition, any method commonly performed in the art may be used.

Through these analysis methods, the amount or pattern of mRNA in a biological sample of a liver cancer patient can be compared with a reference value, from which the expression level, expression pattern, or both differences of the liver cancer prognostic marker of the present invention are detected. It becomes possible to predict the patient's prognosis.

The kit for measuring the amount or pattern of mRNA by RT-PCR includes a primer specific for the mRNA of the liver cancer prognostic marker of the present invention. RT-PCR kits can be used in test tubes or other suitable containers, reaction buffers, deoxynucleotides (dNTPs), enzymes such as Taq-polymerase and reverse transcriptase, DNase, RNase inhibitor DEPCwater, sterilization according to the specific implementation. It may include a number and the like. Primers can initiate DNA synthesis in the presence of a reagent for polymerization (ie, DNA polymerase or reverse transcriptase) and four different nucleoside triphosphates at an appropriate buffer and temperature.

Methods for measuring the abundance or presence pattern of proteins using antibodies include Western blot, ELISA (enzyme linked immunosorbent assay), radioimmunoassay, radioimmunodiffusion, and Ouchterlony. There are immunodiffusion method, rocket immunoelectrophoresis, tissue immunostaining, immunoprecipitation assay, complement fixation assay, FACS, protein chip, etc. Any method performed by the method can be used.

Through these analysis methods, it is possible to compare the amount of antigen-antibody complex formation in a sample of a target liver cancer patient with a reference value, and the abundance or presence pattern of the protein encoded by the liver cancer prognostic marker of the present invention. And ultimately predict the prognosis of liver cancer patients. Here, "antigen-antibody complex" refers to a combination of a protein encoded by a liver cancer prognostic marker and an antibody specific thereto, and the amount or pattern of formation of the antigen-antibody complex is usually a detection label linked to a secondary antibody. ) Can be measured by detecting the size and pattern of the signal. Examples of such detection labels include enzymes, fluorescent substances, ligands, luminescent substances, microparticles, redox molecules, and radioisotopes, but are not limited thereto. When an enzyme is used as a detection label, available enzymes include β-glucuronidase, β-D-glucosidase, β-D-galactosidase, urease, peroxidase or alkaline phosphatase, acetylcholinese. Therapies, glucose oxidase, hexokinase and GDPase, RNase, glucose oxidase, luciferase, phosphofructokinase, phosphoenolpyruvate carboxylase, aspartate aminotransferase, phospholpyruvate deca But not limited thereto, such as boxylase, β-latamase, and the like. When a fluorescent substance is used as a detection label, available fluorescent substances include fluorescein, isothiocyanate, rhodamine, phycoerytherin, phycocyanin, allophycocyanin, o-phthaldehyde, and fluorescarmine. , Not limited to this. When a ligand is used as a detection label, a biotin derivative may be used as a ligand, but is not limited thereto. When a luminescent substance is used as a detection label, available luminescent substances include, but are not limited to, acridinium ester, luciferin, luciferase, and the like. When microparticles are used as the detection label, available microparticles include colloidal gold and colored latex, but are not limited thereto. When a redox molecule is used as a detection label Available redox molecules include ferrocene, ruthenium complex, biologene, quinone, Ti ion, Cs ion, diimide, 1,4-benzoquinone, hydroquinone, K4W(CN)8 , [Os(bpy)3]2+, [RU(bpy)3]2+, [MO(CN)8]4-, etc., but are not limited thereto. When a radioactive isotope is used as a detection label, available radioactive isotopes include 3H, 14C, 32P, 35S, 36Cl, 51Cr, 57Co, 58Co, 59Fe, 90Y, 125I, 131I or 186Re, but are not limited thereto.

The measurement value is at least one value selected from the expression level or expression pattern of the gene in step (A) obtained from liver cancer tissue, etc., and the reference value is a liver cancer patient group (group A1, group A2, group B, group C) who know the prognosis of liver cancer. It may be a risk score obtained from the gene expression level or the expression level when the probability value (p-value, p value) has the lowest value in the result of processing the measurement value obtained from) by the continuous variable regression method ( N Engl J. Med 2007; 356: 11-20). The measured value and the reference value are the expression levels or expression patterns (high or low expression) obtained in the same manner, and control genes (group) showing a constant expression level regardless of liver cancer (B2M, GAPDH, HMBS, HPRT1, and SDHA, etc.) ) Can be determined based on the average expression.

The measured value of liver cancer patients is compared with the reference value obtained from the above patient group to detect the difference, and any substance capable of detecting such difference can be used to determine the expression level, expression pattern, or both of the liver cancer prognostic marker. It can be used as a substance to specifically detect, and the detection result of the difference between the reference value and the measured value can provide information for determining treatment for liver cancer.

In addition, the present invention is one selected from the group consisting of the genes described in Table 2 (described in the composition or kit for predicting liver cancer prognosis for predicting the prognosis for each stage of liver cancer of the present invention) among samples collected from (A) liver cancer patients. Or measuring at least one selected from two or more gene expression levels or expression patterns; And (B) predicting a liver cancer prognosis by comparing the measured value of step (A) with a reference value.

The group consisting of the genes may further include the genes described in Table 3 (described in the composition or kit for predicting liver cancer prognosis for predicting the prognosis of each liver cancer stage of the present invention).

The matters mentioned in the method for predicting the prognosis of liver cancer for predicting the prognosis for each stage of liver cancer of the present invention are equally applied to the above method unless contradictory.

In addition, the matters mentioned in the composition or kit of the present invention apply equally to the method of the present invention, unless contradictory.

The liver cancer prognosis prediction method of the present invention may be a method of providing information for predicting liver cancer prognosis.

In addition, the present invention provides a use of the nucleic acid or antibody contained in the composition of the present invention to predict the prognosis of liver cancer.

In addition, it provides a nucleic acid or antibody for predicting prognosis of liver cancer, wherein the nucleic acid or antibody is included in the composition of the present invention.

Matters mentioned in the markers, compositions or kits, methods, and uses of the present invention apply equally to each other, unless contradictory to each other.

By the markers, compositions, kits, and methods of the present invention, it is possible to effectively predict the prognosis of liver cancer, preferably, predict the prognosis of liver cancer by stage.

1 shows the BCLC classification table.
2 to 106 are Kaplan-Meier curves showing the liver cancer prognostic markers of the present invention measured in terms of recurrence, survival, and disease-free survival.

Hereinafter, the present invention will be described in more detail by examples, but this is only intended to aid understanding of the present invention and is not intended to limit the scope of the present invention in any way.

Example One: Liver cancer prognosis prediction

In the following method, markers useful for predicting the prognosis of liver cancer were discovered, and it was confirmed that the prognosis of liver cancer could be predicted by using them.

1-1. RNA extraction and cDNA synthesis

Liver cancer tissues and surrounding normal tissues of 547 liver cancer patients whose onset of liver cancer was diagnosed and progress was confirmed were obtained. The liver cancer patients were patients who underwent liver cancer resection without additional treatment after diagnosis, and the tissue was frozen and stored prior to liver cancer resection.

RNA of each tissue was extracted and cDNA was synthesized according to the following method.

Total RNA was extracted from liver cancer tissues and surrounding normal tissues according to the user's manual using RNeasy Minikit (Qiagen, Germany). The obtained RNA extract was quantified for total RNA using Bioanalyzer 2100 (Agilent Technologies, USA). In the extraction step, DNase I was treated to remove contaminated genomic DNA from the RNA extract. A sample containing 4 μg of total RNA was incubated with 2 μl of 10 μM oligod(T)18 primer (Genotech Korea) for 7 minutes at 70° C., and cooled for 5 minutes on ice. Enzyme mixture [0.1 M DTT (Duchefa, Netherlands) 2 μl, 10× reverse transcription buffer 2 μl, 2 mM dNTP 5 μl, 200 U/μl MMLV reverse transcriptase 1 μl, and 40 U/μl RNase inhibitor (Enzynomics Korea) 1 μl; A total of 11 μl] was prepared separately. The enzyme mixture was added to the sample containing the RNA, incubated at 42°C for 90 minutes, and then incubated at 80°C for 10 minutes to inactivate the reverse transcriptase. Diethyl pyrocarbonate (DEPC)-treated water was added to the sample so that the final volume became 400 μl.

1-2. Quantitative real-time PCR

For each of the cDNA samples obtained in Example 1-1, real-time PCR amplification was performed for the gene markers shown in the following table according to the user's manual using PRISM 7900HT (Applied Biosystems, USA).

Real-time PCR analysis was performed using 2×Takman gene expression main mixture (Applied Biosystems, USA) 5 μl, 5 μM forward and reverse primers each 1 μl, 1 μM probe (Genotech Korea) 1 μl, cDNA 2 μl (for the control group, the same amount Real-time PCR analysis was performed in a total volume of 10 μl consisting of (water). After the dissociation step at 95° C. for 10 minutes, dissociation at 95° C. for 15 seconds, and amplification through the synthesis cycle at 60° C. for 1 minute. Primer and probe sequences were designed using Primer Express 3.0 (Applied Biosystems, USA), and all probe sequences were labeled with FAM at the 5'end and TAMRA at the 3'end. For each marker in the following table, primer and probe sequences as shown in Table 16 were used.

[Table 16]

Expression of each marker gene was measured by repeating three times, and normalized by subtracting the average expression of five reference genes (B2M, GAPDH, HMBS, HPRT1, and SDHA). For the reference gene, primers and probe sequences shown in Table 17 below were used.

[Table 17]

The CT of each marker (number of cycles required to achieve the baseline value) was measured, the ΔCT value (CT of each marker-the mean CT of the reference gene) was calculated, and the copy number of mRNA was calculated as 2^-ΔCT. A standard curve was completed from the results of the simultaneous amplification of serial dilutions of cDNA samples.

From the above results, it can be seen that the expression level and expression pattern of the marker can be measured by the nucleic acid contained in the composition of the present invention. In addition, since mRNA, which is a transcript, is translated into protein, it can be seen that the expression level and expression pattern of the marker can be measured by the antibody included in the composition of the present invention.

1-3. Statistical analysis

The significance test was performed after completing the Kaplan-Meier curve, taking into account the normalized expression for each marker obtained in Example 1-2, and the course of the patient who provided each tissue.

The predictions of recurrence, survival, and disease-free survival were listed in order of short duration based on the progress of patients who provided liver cancer tissue. Interval survival rate (or recurrence rate) was calculated by dividing the surviving patients (or relapsed patients) by the number of subjects exposed to risk. The cumulative survival rate (or cumulative recurrence rate) is a conditional probability, and was obtained by multiplying the current interval survival rate (or interval recurrence rate) by the previous cumulative survival rate (or cumulative recurrence rate). The Kaplan-Meier curve was completed by plotting as a step function with the horizontal axis as the survival time (or observation period) and the vertical axis as the cumulative survival rate (or cumulative recurrence rate).

For each marker, a Kaplan-Meier curve for prediction of recurrence, survival, and disease-free survival was completed. The expression of each marker measured in Example 1-2 was classified into high and low expression based on an experimentally determined statistically significant reference value, and Kaplan- The Meyer curve was completed. The reference value was selected as the reference value for the gene expression value when the probability value (p-value, p value) has the lowest value in the result of continuous variable regression analysis ( N Engl J Med 2007; 356: 11-20). Graphs were created by applying to the Kaplan-Meier curve ( J. Amer . Statist. Assn . 53:457481, 1958). The criterion for determining significance in the Kaplan-Meier curve was that the probability value (p-value, p value) in a single gene or combination was lower than 0.05.

Kaplan-Meier curves for prediction of recurrence, survival, and disease-free survival for 57 single genes, 31 single genes, and a gene group consisting of two or more combinations were prepared in 547 patients with unstage liver cancer. Results for 57 single genes are shown in Figs. 2 to 22. Figures 2 to 8 are recurrent Kaplan-Meier curves for 57 species single gene group, Figures 9 to 15 are survival Kaplan-Meier curves for 57 single gene groups, and Figures 16 to 22 are for 57 single gene groups. It is a Kaplan-Meier curve for prediction of disease-free survival.

As can be seen in the figure, in the Kaplan-Meier curve completed in the prediction surface of Recurrence, Overall Survival, and Disease-free Survival, each marker is in the case of high expression and low expression. A curve was formed that clearly distinguishes the cases of. This means that there is a significant difference in the interval recurrence rate or interval survival rate, and the cumulative recurrence rate or cumulative survival rate based on the high and low expression of each marker, and as a result, the expression pattern of each marker is the possibility of recurrence of the patient in the future. In other words, it can be an indicator of viability or viability.

In addition, for each marker and combination of markers, the significance by the log-rank method is a method of calculating the observed value and the expected value at each point of recurrence or death to obtain a chi-square test statistic. Probability values (p-value, p-value) were calculated by performing the test. The results are shown in Tables 18 to 21 below. Table 18 is the results for the 57 markers, Tables 19 to 21 are the results for the 31 marker single and combination. Among them, Table 19 shows recurrence among 31 markers, Table 20 shows survival among 31 markers, and Table 21 shows the results for predicting disease-free survival among 31 markers.

[Table 18]

[Table 19]

[Table 20]

[Table 21]

Each marker or a combination of both showed a significantly low probability value (p-value, p-value) for all predictions of recurrence, survival, and disease-free survival. In particular, in the case of a combination of two or more markers, all probability values (p-value, p-value) for prediction of recurrence, survival, and disease-free survival were preferably less than 0.05. The lower the probability value (p-value, p value) is, the greater the statistical significance.The low probability value (p-value, p value) means that the accuracy of predicting liver cancer prognosis according to each marker or a combination of the two is more accurate. Suggests it will be high.

This result can be seen that the more the markers of the present invention are combined, the lower the probability value (p-value, p value) is. This means that the more the markers of the present invention are combined, the more significantly lower probability values (p-value, p-value) are displayed, and it can be seen that the accuracy of prognostic prediction based on the combination of these markers will be further improved. .

In addition, it can be seen that the liver cancer prognosis of group A2 can be effectively predicted by the method for predicting liver cancer prognosis of the present invention targeting the above markers.

In addition, patients who were not staged for 31 genes were divided into two random groups (positive group: 274 patients, test group: 273 patients), and recurrence and survival in the test group while the baseline value that was statistically significant in the positive group was fixed. , In terms of disease-free survival prediction, the prediction accuracy was calculated at a level of p<0.05, or p<0.001, and cross-validation was performed.

Among the cross-validation results of predicting recurrence, survival, and disease-free survival in at least two combinations of 31 genes for all patients who have not been classified as staging, representative examples showing excellent prediction accuracy in each aspect are as follows.

Recurrence: ATG3_FASLG_ID2_RPS19BP1_SESN3_TCF3 (94% at p<0.05 level)

Survival: CSE1L_FAS_FRAP1_CDH1_BHLHE41_SESN2 (95% at p<0.0001 level)

Disease free survival: ATG12_FASLG_ID2_STAT3_RPS19BP1_TCF3 (95.0% at p<0.05 level)

Example 2: in group A1 Liver cancer prognosis prediction

A1 group {a group of patients with stage 0 or A according to BCLC (Barcelona-Clinic Liver Cancer) stage classification, with a tumor size of 5 cm or less alone or with 3 or less tumors and portal vein invasion negative} It was carried out in the same manner as in Example 1, except that it was carried out for (277 patients). A Kaplan-Meier curve for predicting recurrence, survival, and disease-free survival was created, and the results are shown in Figs. 23 to 43. Figures 23-29 are Kaplan-Meier curves of recurrence, Figures 30-36 are Kaplan-Meier curves of survival, and Figures 37-43 are Kaplan-Meier curves of disease-free survival prediction.

As can be seen in the figure, in the Kaplan-Meier curve completed in terms of prediction of Recurrence, Overall Survival, and Disease-free Survival, each marker is in the case of high expression and low expression. A curve was formed that clearly distinguishes the cases of. This means that there is a significant difference in the interval recurrence rate or interval survival rate, and the cumulative recurrence rate or cumulative survival rate based on the high and low expression of each marker, and as a result, the expression pattern of each marker is the possibility of recurrence of the patient in the future. In other words, it can be an indicator of viability or viability.

In addition, for each marker and combination of markers, probability values (p-value, p-value) obtained by performing a significance test by the log-rank method by calculating the observed value and expected value at each time point of recurrence or death occurred. ) Is shown in Tables 22 to 29 below. Table 22 is a marker alone, Table 23 is a combination of two, Table 24 is a combination of 3, Table 25 is a combination of 4, Table 26 is a combination of 5, Table 27 is a combination of 6, Table 28 is a combination of 7, Table 29 Is the result for 8 combinations.

[Table 22]

[Table 23]

[Table 24]

[Table 25]

[Table 26]

[Table 27]

[Table 28]

[Table 29]

As can be seen from the above table, each marker or combination showed a significantly low probability value (p-value, p value) for all predictions of recurrence, survival, and disease-free survival. In particular, in the case of a combination of two or more markers, it can be seen that all probability values (p-value, p-value) for prediction of recurrence, survival, and disease-free survival are low. In particular, it can be seen that there is a case in which the probability value (p-value, p value) is relatively high in the marker alone, or the probability value (p-value, p value) is lowered by the combination. The lower the probability value (p-value, p value) is, the greater the statistical significance.The low probability value (p-value, p value) indicates that the accuracy of predicting liver cancer prognosis according to each marker or combination thereof will be high. Suggests a point.

This means that a more significantly lower probability value (p-value, p value) is indicated by the combination of the markers of the present invention, and it can be seen that the accuracy of prognostic prediction based on the combination of these markers will be further improved. have.

As a result, it can be seen that the markers and/or combinations of markers in Tables 22 to 29 are effective in predicting the prognosis (recurrence, survival, disease-free survival) of group A1 liver cancer. It can be seen that the prognosis can be effectively predicted.

In addition, it can be seen that the liver cancer prognosis of group A1 can be effectively predicted by the method for predicting liver cancer prognosis of the present invention targeting the above markers.

In addition, cross-validation was performed for combinations of markers that were statistically significant. Patients in each patient group were divided into two randomized groups (positive group: 139 patients, test group: 138 patients), and the test group with a statistically significant reference value calculated in the same manner as in Example 1 for the positive group was fixed. In terms of prediction of recurrence, survival, and disease-free survival, the prediction accuracy was calculated at a level of p<0.05 or p<0.001.

Among the cross-validation results of predicting recurrence, survival, and disease-free survival for group A1, representative examples showing excellent prediction accuracy in each aspect are as follows.

Recurrence: ATG7_FRAP1_LC3_NNMT_STAT3 (95% at p<0.05 level)

Survival: AKT1_CDH1_ID2 (98.7% at p<0.05 level)

Disease-free survival: FRAP1_LC3_TKT_HMGB1_STAT3_TWIST1 (84.0% at p<0.05 level)

Example 3: in group A2 Liver cancer prognosis prediction

It was carried out in the same manner as in Example 1, except that it was performed for the group A2 (the patient group having a tumor size greater than 5 cm and having a negative portal vein invasion) (123 patients). . Kaplan-Meier curves for predicting recurrence, survival, and disease-free survival were prepared, and the results are shown in Figs. 44 to 64. Figures 44-50 are Kaplan-Meier curves of recurrence, Figures 51-57 are Kaplan-Meier curves of survival, and Figures 58-64 are Kaplan-Meier curves of disease-free survival prediction.

As can be seen in the figure, in the Kaplan-Meier curve completed in terms of prediction of Recurrence, Overall Survival, and Disease-free Survival, each marker is in the case of high expression and low expression. A curve was formed that clearly distinguishes the cases of. This means that there is a significant difference in the interval recurrence rate or interval survival rate, and the cumulative recurrence rate or cumulative survival rate based on the high and low expression of each marker, and as a result, the expression pattern of each marker is the possibility of recurrence of the patient in the future. In other words, it can be an indicator of viability or viability.

In addition, for each marker and combination of markers, probability values (p-value, p-value) obtained by performing a significance test by the log-rank method by calculating the observed value and expected value at each time point of recurrence or death occurred. ) Are shown in Tables 30 to 37 below. Table 30 is a marker alone, Table 31 is a combination of two, Table 32 is a combination of 3, Table 33 is a combination of 4, Table 34 is a combination of 5, Table 35 is a combination of 6, Table 36 is a combination of 7, Table 37 Are the results for 8 combinations.

[Table 30]

[Table 31]

[Table 32]

[Table 33]

[Table 34]

[Table 35]

[Table 36]

[Table 37]

As can be seen from the above table, each marker or combination showed a significantly low probability value (p-value, p value) for all predictions of recurrence, survival, and disease-free survival. In particular, in the case of a combination of two or more markers, it can be seen that all probability values (p-values, p values) for prediction of recurrence, survival, and disease-free survival are low. In particular, it can be seen that there is a case in which the probability value (p-value, p value) is relatively high in the marker alone, or the probability value (p-value, p value) is lowered by the combination. The lower the probability value (p-value, p value) is, the greater the statistical significance.The low probability value (p-value, p value) increases the accuracy of predicting liver cancer prognosis according to each marker or a combination thereof. Suggests that it will.

This means that a more significantly lower probability value (p-value, p value) is indicated by the combination of the markers of the present invention, and it can be seen that the accuracy of prognostic prediction based on the combination of these markers will be further improved. have.

As a result, it can be seen that the markers and/or combinations of markers in Tables 30 to 37 are effective in predicting the prognosis (recurrence, survival, disease-free survival) of group A2 liver cancer. It can be seen that the prognosis can be effectively predicted.

In addition, it can be seen that the liver cancer prognosis of group A2 can be effectively predicted by the method for predicting liver cancer prognosis of the present invention targeting the above markers.

In addition, cross-validation was performed for combinations of markers that were statistically significant. Patients in each patient group were divided into two random groups (62 positive group and 61 test group), and recurrence in the test group with a statistically significant reference value calculated in the same manner as in Example 1 for the positive group. , In terms of survival and disease-free survival prediction, the prediction accuracy was calculated at the level of p<0.05, or p<0.001.

Among the cross-validation results of predicting recurrence, survival, and disease-free survival for group A2, representative examples showing excellent prediction accuracy in each aspect are as follows.

Recurrence: TKT_SESN2_VEGF (65.0% at p<0.05 level)

Survival: DIABLO_FAS_LAMP1_BHLHE41_SESN2 (83.3% at p<0.05 level)

Disease-free survival: TKT_SESN2_VEGF (82.0% at p<0.05 level)

Example 4: in group B Liver cancer prognosis prediction

A group of patients judged as group B {intermediate stage patients according to BCLC stage classification, ascites tumors with a tumor size of more than 3cm or ascites tumors with a tumor size greater than 3 and negative for portal vein invasion} (number of patients) 78 people), except that it was carried out in the same manner as in Example 1. A Kaplan-Meier curve for predicting recurrence, survival, and disease-free survival was created, and the results are shown in Figs. 65-85. Figures 65-71 are Kaplan-Meier curves of recurrence, Figures 72-78 are Kaplan-Meier curves of survival, and Figures 79-85 are Kaplan-Meier curves of disease-free survival prediction.

As can be seen in the figure, in the Kaplan-Meier curve completed in terms of prediction of Recurrence, Overall Survival, and Disease-free Survival, each marker is in the case of high expression and low expression. A curve was formed that clearly distinguishes the cases of. This means that there is a significant difference in the interval recurrence rate or interval survival rate, and the cumulative recurrence rate or cumulative survival rate based on the high and low expression of each marker, and as a result, the expression pattern of each marker is the possibility of recurrence of the patient in the future. In other words, it can be an indicator of viability or viability.

In addition, for each marker and combination of markers, the observed value and the expected value were calculated at each time point of recurrence or death, and a significance test was performed by the log-rank method to determine probability values (p-value, p-value). The probability values (p-value, p value) obtained by calculating the are shown in Tables 38 to 45 below. Table 38 is a marker alone, Table 39 is a combination of two, Table 40 is a combination of 3, Table 41 is a combination of 4, Table 42 is a combination of 5, Table 43 is a combination of 6, Table 44 is a combination of 7, Table 45 Is the result for 8 combinations.

[Table 38]

[Table 39]

[Table 40]

[Table 41]

[Table 42]

[Table 43]

[Table 44]

[Table 45]

As can be seen from the above table, each marker or combination showed a significantly low probability value (p-value, p value) for all predictions of recurrence, survival, and disease-free survival. In particular, in the case of a combination of two or more markers, it can be seen that all probability values (p-value, p-value) for prediction of recurrence, survival, and disease-free survival are low. In particular, it can be seen that there is a case in which the probability value (p-value, p value) is relatively high in the marker alone, or the probability value (p-value, p value) is lowered by the combination. The lower the probability value (p-value, p value) is, the greater the statistical significance.The low probability value (p-value, p value) indicates that the accuracy of predicting liver cancer prognosis according to each marker or combination thereof will be high. Suggests a point.

This means that a more significantly lower probability value (p-value, p value) is indicated by the combination of the markers of the present invention, and it can be seen that the accuracy of prognostic prediction based on the combination of these markers will be further improved. have.

As a result, it can be seen that the markers and/or combinations of markers in Tables 38 to 45 are effective in predicting the prognosis (recurrence, survival, disease-free survival) of group B liver cancer. It can be seen that the prognosis can be effectively predicted. In addition, it can be seen that the liver cancer prognosis of group B can be effectively predicted by the method for predicting liver cancer prognosis of the present invention targeting the above markers.

In addition, cross-validation was performed for combinations of markers that were statistically significant. Patients in each patient group were divided into two randomized groups (39 in the positive group and 39 in the test group), and recurrence in the test group with a statistically significant reference value calculated in the same manner as in Example 1 for the positive group, In terms of survival and disease-free survival prediction, the prediction accuracy was calculated at a level of p<0.05, or p<0.001.

Among the results of cross-validation of survival for group B, representative examples showing excellent prediction accuracy in each aspect are as follows.

Survival: DIABLO_BECN1_SIRT1 (79.7% at p<0.05 level)

Example 5: in group C Liver cancer prognosis prediction

It was carried out in the same manner as in Example 1, except that the patient group (69 patients) was judged as group C (regardless of the size or number of cancers). Kaplan-Meier curves for predicting recurrence, survival, and disease-free survival were prepared, and the results are shown in Figs. 86-106. Figures 86-92 are Kaplan-Meier curves of recurrence, Figures 93-99 are Kaplan-Meier curves of survival, and Figures 100-106 are Kaplan-Meier curves of disease-free survival prediction.

As can be seen in the figure, in the Kaplan-Meier curve completed in terms of prediction of Recurrence, Overall Survival, and Disease-free Survival, each marker is in the case of high expression and low expression. A curve was formed that clearly distinguishes the cases of. This means that there is a significant difference in the interval recurrence rate or interval survival rate, and the cumulative recurrence rate or cumulative survival rate based on the high and low expression of each marker, and as a result, the expression pattern of each marker is the possibility of recurrence of the patient in the future. In other words, it can be an indicator of viability or viability.

In addition, for each marker and combination of markers, the observed value and the expected value were calculated at each time point of recurrence or death, and a significance test was performed using the log-rank method to determine probability values (p-value, p-value). The probability values (p-value, p value) obtained by calculating the are shown in Tables 46 to 53 below. Table 46 is a marker alone, Table 47 is a combination of two, Table 48 is a combination of 3, Table 49 is a combination of 4, Table 50 is a combination of 5, Table 51 is a combination of 6, Table 52 is a combination of 7, Table 53 Are the results for 8 combinations.

*[Table 46]

[Table 47]

[Table 48]

[Table 49]

[Table 50]

[Table 51]

[Table 52]

[Table 53]

The table above shows the probability values (p-value, p-value) for each gene and its combination.

As can be seen from the above table, each marker or combination showed a significantly low probability value (p-value, p value) for all predictions of recurrence, survival, and disease-free survival. In particular, in the case of a combination of two or more markers, it can be seen that all probability values (p-value, p-value) for prediction of recurrence, survival, and disease-free survival are low. In particular, it can be seen that there is a case in which the probability value (p-value, p value) is relatively high in the marker alone, or the probability value (p-value, p value) is lowered by the combination. The lower the probability value (p-value, p value) is, the greater the statistical significance.The low probability value (p-value, p value) indicates that the accuracy of predicting liver cancer prognosis according to each marker or combination thereof will be high. Suggests a point.

This means that a more significantly lower probability value (p-value, p value) is indicated by the combination of the markers of the present invention, and it can be seen that the accuracy of prognostic prediction based on the combination of these markers will be further improved. have.

As a result, it can be seen that the markers and/or combinations of markers in Tables 41 to 48 are effective in predicting the prognosis (recurrence, survival, disease-free survival) of group C liver cancer, and by nucleic acids and antibodies targeting the markers, group C liver cancer It can be seen that the prognosis can be effectively predicted. In addition, it can be seen that the liver cancer prognosis of group C can be effectively predicted by the method for predicting liver cancer prognosis of the present invention targeting the above markers.

In addition, cross-validation was performed for combinations of markers that were statistically significant. Patients in each patient group were divided into two random groups (35 in the positive group and 34 in the test group), and for the positive group, recurrence in the test group while fixing the statistically significant reference value calculated in the same manner as in Example 1, In terms of survival and disease-free survival prediction, the prediction accuracy was calculated at a level of p<0.05, or p<0.001.

Among the cross-validation results of predicting recurrence, survival, and disease-free survival for group C, representative examples showing excellent prediction accuracy in each aspect are as follows.

Recurrence: FAS_TCF3_FASLG_RPS19BP1 (69.0% at p<0.05 level)

Survival: CASP3_CDH2_CIAP2 (77.0% at p<0.05 level)

Disease Free Survival: FAS_TCF3_FASLG (75.0% at p<0.05 level)

<110> CbsBiosciences, Inc <120> Composition or Kit and Method for predicting prognosis of liver cancer <130> P10-065-CBS <160> 243 <170> KopatentIn 1.71 <210> 1 <211> 5166 <212> DNA <213> Homo sapiens <400> 1 aatgagcgct ccgggtctca gcggggtgga ggggttgcac tgcggtaata tggctcttcc 60 ttagccagcg gcggcaacgg cggcagcggc ggcagcggcg gcggctactg tctgggctga 120 gcagtagtgc ctctcgggtg gcgggtttct aggctgcagg ggcttggtag gtggtggcaa 180 gggggcggcg gcggatgccg gaagagtgcc cgccccgccg cttggcggcc cctggatcga 240 gatgagcgcc tccgcgtcgg tcgggggccc cgtcccccag ccacccccgg gcccggccgc 300 tgctctgcct cccggttctg ccgcgcgggc cctgcatgtg gagctgccgt ctcagcagcg 360 gcgtcttcga catcttcgga acattgctgc ccggaacatt gttaatagaa atggccatca 420 gctccttgat acctacttta cacttcactt gtgtagtact gaaaagatat ataaagaatt 480 ttatagaagt gaagtgatta agaattcctt gaatcccacg tggcgaagtc tcgattttgg 540 aattatgcca gaccgtcttg atacatctgt gtcttgtttc gtggtgaaga tatggggtgg 600 aaaggagaac atctaccagc tgttgattga atggaaagtc tgtttggatg ggctgaaata 660 cttgggtcag cagattcatg cccgaaacca aaatgaaata atttttgggc tgaatgatgg 720 atactatggt gctccatttg aacataaggg ttattcaaat gctcagaaga ctattcttct 780 gcaggtggat cagaactgtg ttcgcaattc ttacgatgtc ttctctttgc tacggcttca 840 tagagcccag tgtgcaatta aacagactca ggtaactgtt cagaaaattg gaaaggaaat 900 tgaagaaaaa ctaagactca catctacaag caatgaactg aaaaaaaaaa gtgaatgcct 960 gcagttaaaa attttggtgc ttcagaatga actggaacgg cagaagaaag ctttgggacg 1020 ggaggtggca ttactgcata agcaacaaat tgcattacaa gacaaaggaa gtgcattttc 1080 agctgagcac ctcaaacttc aactccagaa ggaatcccta aatgagctga ggaaggagtg 1140 cactgcaaaa agagaactct tcttgaagac taatgctcag ttgacaattc gttgcaggca 1200 gttactctct gagctttcct acatttaccc tattgatttg aatgaacata aggattactt 1260 tgtatgcggt gtcaagttgc ctaattctga ggacttccaa gcaaaagatg atggaagcat 1320 tgctgttgcc cttggttata ctgcacatct ggtctccatg atttcctttt tcctacaagt 1380 gcccctcaga tatcctataa ttcataaggg gtctagatca acaatcaaag acaatatcaa 1440 tgacaaactg acggaaaagg agagagagtt tccactgtat ccaaaaggag gggagaagtt 1500 gcagtttgat tatggtgtct atcttctgaa caaaaatata gcacagctaa gatatcaaca 1560 tggactaggg actccagact tgcggcaaac ccttcccaac ctgaaaaact tcatggagca 1620 tggactaatg gtcaggtgtg acagacatca cacctccagt gcaatccctg ttcctaagag 1680 acaaagctcc atatttgggg gtgcagatgt aggcttctct ggggggatcc cttcaccaga 1740 caaaggacat cgaaaacggg ccagctctga gaatgagaga cttcagtaca aaacccctcc 1800 tcccagttac aactcagcat tagcccagcc tgtgaccacc gtcccctcca tgggagagac 1860 cgagagaaag ataacatctc tatcctcctc cttggatacc tccttggact tctccaaaga 1920 aaacaagaaa aaaggagagg atctagttgg cagcttaaac ggaggccacg cgaatgtgca 1980 ccctagccaa gaacaaggag aagccctctc cgggcaccgg gccacagtca atggcactct 2040 cctacccagc gagcaggccg ggtccgccag tgtccagctt ccaggcgagt tccacccagt 2100 ctcagaagct gagctctgct gtactgtgga gcaagcagaa gaaatcatcg ggctggaagc 2160 cacaggtttc gcctcaggtg atcagctaga agcatttaac tgcatcccag tggacagtgc 2220 tgtggcagta gagtgtgacg aacaagttct gggagaattt gaagagttct cccgaaggat 2280 ctatgcactg aatgaaaacg tatccagctt ccgccggccg cgcaggagtt ccgataagtg 2340 aagtgagcag gtcaacagta ggactggggc agaagctctg cctaaaatga agtgaaagct 2400 gcacttaacc ctttgtgata atgatgacac aaaatgaata ttaatggagg atattcctcg 2460 gaaaaacaga ctttgggaat gaaggaggga ctcaggatca ttgttatcag tgggccaaag 2520 ttagattttg ctttcaagat ttgcttttcg ggcctgatga ttttaaagca aaaatcaccc 2580 tctagttgaa agagcttaca gctcgagtca ccttttagct atttgtctgc tttttattta 2640 cccttgtatg ttatcctcag agggaagatg ataatatata aataatataa tgaacacacc 2700 cttagtttct cataagcatt tgccctcacc atggtttata aaactttggg aaaacggaat 2760 attcagaaat aggtttccgc catgtactga aaggtctgtg gccatctgtg aggtagatga 2820 agaagcagca tagtggtctc cttacatcta ggcctaactg tccctcttcc tgcccccggg 2880 taccacagtc cacctttaga ccctactgtc gccccatctt ctccgtggat gggccatgcg 2940 tcctgaaaac aggacatcag attcactggt tctgtaaccc agtagctgtg acgttccatc 3000 tcttctaacc agccatggcc ttcccctcct ctgccatacc cttaatgcgg ccctcagatt 3060 agatgaaaaa cttgctcctg gtggatccca agggaccctc aaggacctcg aggttactgc 3120 agtcagatgc catctcatcc cctgtggggg ccaaagtttt tatgtgggca gatgctgtgg 3180 tcaggaacta ggcatgcttt ctggcaatgc actcaccaga caaaaatccc ttgatgtaaa 3240 tcccatgtta atttattaaa tttcagtcag aaggtcagca tttacatgac agaatgtatg 3300 tagagagttg gggtgtctgg taggcaaact gcaaggcagt tgagatagtt ggattaagag 3360 gctagacgag acatagaata ctattggtat gtgtgcaatt tcatgaatat taaattatgt 3420 ttcgaagtcc agttgtcatt cccgcattca gatttcattt gctgttgctt tatacgttac 3480 gtacccaagg acattgcctc agggttgcaa actctttaaa ggaaaattta tccatatatc 3540 catgtattat atagaagaat aaaaattgag tttacttcac ccgacctgat ttttttttac 3600 cagcttggaa attcctcttg aacctacgtc tccatatgtc acatcatgac aggactagcc 3660 tgaacaaaag ccatgtctat ctaagcggag gctgttgact tcattcagtt tgcatattgt 3720 atatagcaac acaaacactt gacaggtata tactccagtc gccacatttg tcctgcataa 3780 cagcttcact cacaggcctc accgtcactt tattttgtgt ccaagcattc ctgggctcaa 3840 gtttaatgta tagctacatt gttgttttcc atgtagagaa ctcacaggat gactacatca 3900 caaataaacc caactctcag gcagtcgaaa gctttaactg gatctgcaga agcccatctt 3960 cctccacatg aagaagtggg gctccttcac ctagagcagg agcttctctg cagtgtactg 4020 tctgtcgctc attttggagt cagtgtgggt ggagacagca tcgtggatat gcacgtgctg 4080 cggggccctc cagggaagta acatttacca aaaaaaaaga aaagttctga agggcagtgt 4140 taggattgca gaatggaagg tcaaccccgt gggacttacg attgccccag gtgcgggatg 4200 gacttaaatg tcacaccaaa ctcaaagtag gtacactggg ttgcagggca tccagcctgg 4260 cgctggcacc accaaggagc aggactcctc atgattacag tgtccatctc aggcccacac 4320 aaccatgaga gcctggactc tggggtctac ccgtcagtgc cccccaccgc tgtgcagact 4380 ccctggttga tcctgggctt gtggcttttc accgcacggc ggggagccct gctcttgaat 4440 gtcatcgggc tgctcagagc tgattgctag gtgcctacac atttgcctcg acccacacag 4500 ccccgtggtg atgcctcaaa acaccactta ggtttgggtt cgtttagttc gagtttgggg 4560 ttttcatttg aacttgtttg atgtctgcag tttctgccat gacctgggta gaacctatgg 4620 gattacccgt ctcctggaat aactgtttga cgttttccaa agttgtagag ttagtatggc 4680 ctctgtttaa agtggctggg gccaaaataa gggatgagtt attatctcct actaaccttt 4740 tagttttgta aatcactaag aaaattgttt gcttggaaga tataagttga attggaaact 4800 cattactatc tatttctgaa ctgctaagaa ccctttcagt tttcttacag ctgagacact 4860 tttaaacagc gggcaaatgt tatcaaatga atatttgatt gtgttttttc tcttcacttc 4920 cccttaacca ctttagaaat tccagagatt tttttcccct cagaatatta gttttggaag 4980 attgtgccca gctatatatt ttttagcagt tctaatggtg cccatttatc ctgacctaac 5040 cagttattta aataattttt taaaccacca cgaataataa atggcatgtg aaactgatct 5100 gttggtaact ggaagaaaac tcagcatctg tatttataca ataaaattga ttagtattta 5160 ttttga 5166 <210> 2 <211> 4593 <212> DNA <213> Homo sapiens <400> 2 gctgccgcgc cccgcccttt ctcggccccc ggagggtgac ggggtgaagg cgggggaacc 60 gaggtgggga gtccgccaga gctcccagac tgcgagcacg cgagccgccg cagccgtcac 120 ccgcgccgcg tcacggctcc cgggcccgcc ctcctctgac ccctcccctc tctccgtttc 180 cccctctccc cctcctccgc cgaccgagca gtgacttaag caacggagcg cggtgaagct 240 catttttctc cttcctcgca gccgcgccag ggagctcgcg gcgcgcggcc cctgtcctcc 300 ggcccgagat gaatcctgcg gcagaagccg agttcaacat cctcctggcc accgactcct 360 acaaggttac tcactataaa caatatccac ccaacacaag caaagtttat tcctactttg 420 aatgccgtga aaagaagaca gaaaactcca aattaaggaa ggtgaaatat gaggaaacag 480 tattttatgg gttgcagtac attcttaata agtacttaaa aggtaaagta gtaaccaaag 540 agaaaatcca ggaagccaaa gatgtctaca aagaacattt ccaagatgat gtctttaatg 600 aaaagggatg gaactacatt cttgagaagt atgatgggca tcttccaata gaaataaaag 660 ctgttcctga gggctttgtc attcccagag gaaatgttct cttcacggtg gaaaacacag 720 atccagagtg ttactggctt acaaattgga ttgagactat tcttgttcag tcctggtatc 780 caatcacagt ggccacaaat tctagagagc agaagaaaat attggccaaa tatttgttag 840 aaacttctgg taacttagat ggtctggaat acaagttaca tgattttggc tacagaggag 900 tctcttccca agagactgct ggcataggag catctgctca cttggttaac ttcaaaggaa 960 cagatacagt agcaggactt gctctaatta aaaaatatta tggaacgaaa gatcctgttc 1020 caggctattc tgttccagca gcagaacaca gtaccataac agcttggggg aaagaccatg 1080 aaaaagatgc ttttgaacat attgtaacac agttttcatc agtgcctgta tctgtggtca 1140 gcgatagcta tgacatttat aatgcgtgtg agaaaatatg gggtgaagat ctaagacatt 1200 taatagtatc aagaagtaca caggcaccac taataatcag acctgattct ggaaaccctc 1260 ttgacactgt gttaaaggtt ttggagattt taggtaagaa gtttcctgtt actgagaact 1320 caaagggtta caagttgctg ccaccttatc ttagagttat tcaaggggat ggagtagata 1380 ttaatacctt acaagagatt gtagaaggca tgaaacaaaa aatgtggagt attgaaaata 1440 ttgccttcgg ttctggtgga ggtttgctac agaagttgac aagagatctc ttgaattgtt 1500 ccttcaagtg tagctatgtt gtaactaatg gccttgggat taacgtcttc aaggacccag 1560 ttgctgatcc caacaaaagg tccaaaaagg gccgattatc tttacatagg acgccagcag 1620 ggaattttgt tacactggag gaaggaaaag gagaccttga ggaatatggt caggatcttc 1680 tccatactgt cttcaagaat ggcaaggtga caaaaagcta ttcatttgat gaaataagaa 1740 aaaatgcaca gctgaatatt gaactggaag cagcacatca ttaggcttta tgactgggtg 1800 tgtgttgtgt gtatgtaata cataatgttt attgtacaga tgtgtggggt ttgtgtttta 1860 tgatacatta cagccaaatt atttgttggt ttatggacat actgcccttt catttttttt 1920 cttttccagt gtttaggtga tctcaaatta ggaaatgcat ttaaccatgt aaaagatgag 1980 tgctaaagta agctttttag ggccctttgc caataggtag tcattcaatc tggtattgat 2040 cttttcacaa ataacagaac tgagaaactt ttatatataa ctgatgatca cataaaacag 2100 atttgcataa aattaccatg attgctttat gtttatattt aacttgtatt tttgtacaaa 2160 caagattgtg taagatatat ttgaagtttc agtgatttaa cagtctttcc aacttttcat 2220 gatttttatg agcacagact ttcaagaaaa tacttgaaaa taaattacat tgccttttgt 2280 ccattaatca gcaaataaaa catggcctta acaaagttgt ttgtgttatt gtacaatttg 2340 aaaattatgt cgggacatac cctatagaat tactaacctt actgcccctt gtagaatatg 2400 tattaatcat tctacattaa agaaaataat ggttcttact ggaatgtcta ggcactgtac 2460 agttattata tatcttggtt gttgtattgt accagtgaaa tgccaaattt gaaaggcctg 2520 tactgcaatt ttatatgtca gagattgcct gtggctctaa tatgcacctc aagattttaa 2580 ggagataatg tttttagaga gaatttctgc ttccactata gaatatatac ataaatgtaa 2640 aatacttaca aaagtggaag tagtgtattt taaagtaatt acacttctga atttattttt 2700 catattctat agttggtatg acttaaatga attactggag tgggtagtga gtgtacttaa 2760 atgtttcaat tctgttatat tttttattaa gtttttaaaa aattaaattg gatattaaat 2820 tgtatggaca tcatttatta attttaaact gaatgccctc aataagtaat actgaagcac 2880 attcttaaat gaagataaat tatctccaat gaaaagcatg acatgtgttt caatagaaga 2940 atcttaagtt ggctaaattc aaagtgcttg acatcaaaat gttctagagt gattagctac 3000 tagattctga atcatacatc acatctgact agagaccagt ttctttcgaa tgattctttt 3060 atgtatgtag atctgttctt ctgaggcagc ggttggccaa ctatagccca aaggccaaat 3120 ttggacttct ttttataaat gcagattgtc tatggctgct ttcccactac tccagcctaa 3180 ggtaaacagc tgcaatagaa gccaaatgag aatcgcaaag cccaaaatgt ttattaacct 3240 gccctttaca caaaattaca caaaaagttt cctgatctct gttctaagaa aaggagtgtg 3300 ccttgcattt aaaaggaaat gttggtttct agggaaggga ggaggctaaa taattgatac 3360 ggaattttcc tcttttgtct tcttttttct cacttaagaa tccgatactg gaagactgat 3420 ttagaaaagt ttttaacatg acattaaatg tgaaatttta aaaattgaaa agccataaat 3480 catctgtttt aaatagttac atgagaaaat gatcactaga ataacctaat tagaagtgtt 3540 atcttcatta aatgtttttt gtaagtggta ttagaaagaa tatgtttttc agatggttct 3600 ttaaacatgt agtgagaaca ataagcatta ttcactttta gtaagtcttc tgtaatccat 3660 gatataaaat aattttaaaa tgatttttta atgtatttga gtaaagatga gtagtattaa 3720 gaaaaacaca catttcttca caaaatgtgc taaggggcgt gtaaagaatc aaaagaaact 3780 attaccaata atagttttga taatcaccca taattttgtg tttaaacatt gaaattatag 3840 tacagacagt attctctgtg ttctgtgaat ttcagcagct tcagaataga gtttaattta 3900 gaaatttgca gtgaaaaaag ctatctcttt gttcacaacc ataaatcagg agatggagat 3960 taattctatt ggctcttagt cacttggaac tgattaattc tgactttctg tcactaagca 4020 cttggtattt ggccatctcc attctgagca ccaaacggtt aacacgaatg tccactagaa 4080 ctctgctgtg tgtcaccctt aaatcagtct aaatcttcca gacaaaagca aatggcattt 4140 atggatttaa gtcattagat tttcaactga cattaattaa tccctcttga ttgattatat 4200 catcaagtat ttatatctta aataggaggt aggatttctg tgttaagact cttatttgta 4260 ccctataatt aaagtaaaat gttttttatg agtatccctt gttttccctt cttaaattgt 4320 tatcaaacaa tttttataat gaaatctatc ttggaaaatt agaaagaaaa atggcaaggt 4380 atttattgtt ctgtttgcca taatttagaa ctcacactta agtattttgt agttttacat 4440 tcctttttaa cccattcagt ggagaatgtc agcttttctc ccaagttgta tgttaagtct 4500 attctaatat gtactcaaca tcaagttata aacatgtaat aaacatggaa ataaagttta 4560 gctctattag tgaagtgtta aaaaaaaaaa aaa 4593 <210> 3 <211> 4953 <212> DNA <213> Homo sapiens <400> 3 ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag 60 ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc 120 ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg 180 cgcagccccg gcctctcggc ctctgccgga gaaacaggat ggcccaatgg aatcagctac 240 agcagcttga cacacggtac ctggagcagc tccatcagct ctacagtgac agcttcccaa 300 tggagctgcg gcagtttctg gccccttgga ttgagagtca agattgggca tatgcggcca 360 gcaaagaatc acatgccact ttggtgtttc ataatctcct gggagagatt gaccagcagt 420 atagccgctt cctgcaagag tcgaatgttc tctatcagca caatctacga agaatcaagc 480 agtttcttca gagcaggtat cttgagaagc caatggagat tgcccggatt gtggcccggt 540 gcctgtggga agaatcacgc cttctacaga ctgcagccac tgcggcccag caagggggcc 600 aggccaacca ccccacagca gccgtggtga cggagaagca gcagatgctg gagcagcacc 660 ttcaggatgt ccggaagaga gtgcaggatc tagaacagaa aatgaaagtg gtagagaatc 720 tccaggatga ctttgatttc aactataaaa ccctcaagag tcaaggagac atgcaagatc 780 tgaatggaaa caaccagtca gtgaccaggc agaagatgca gcagctggaa cagatgctca 840 ctgcgctgga ccagatgcgg agaagcatcg tgagtgagct ggcggggctt ttgtcagcga 900 tggagtacgt gcagaaaact ctcacggacg aggagctggc tgactggaag aggcggcaac 960 agattgcctg cattggaggc ccgcccaaca tctgcctaga tcggctagaa aactggataa 1020 cgtcattagc agaatctcaa cttcagaccc gtcaacaaat taagaaactg gaggagttgc 1080 agcaaaaagt ttcctacaaa ggggacccca ttgtacagca ccggccgatg ctggaggaga 1140 gaatcgtgga gctgtttaga aacttaatga aaagtgcctt tgtggtggag cggcagccct 1200 gcatgcccat gcatcctgac cggcccctcg tcatcaagac cggcgtccag ttcactacta 1260 aagtcaggtt gctggtcaaa ttccctgagt tgaattatca gcttaaaatt aaagtgtgca 1320 ttgacaaaga ctctggggac gttgcagctc tcagaggatc ccggaaattt aacattctgg 1380 gcacaaacac aaaagtgatg aacatggaag aatccaacaa cggcagcctc tctgcagaat 1440 tcaaacactt gaccctgagg gagcagagat gtgggaatgg gggccgagcc aattgtgatg 1500 cttccctgat tgtgactgag gagctgcacc tgatcacctt tgagaccgag gtgtatcacc 1560 aaggcctcaa gattgaccta gagacccact ccttgccagt tgtggtgatc tccaacatct 1620 gtcagatgcc aaatgcctgg gcgtccatcc tgtggtacaa catgctgacc aacaatccca 1680 agaatgtaaa cttttttacc aagcccccaa ttggaacctg ggatcaagtg gccgaggtcc 1740 tgagctggca gttctcctcc accaccaagc gaggactgag catcgagcag ctgactacac 1800 tggcagagaa actcttggga cctggtgtga attattcagg gtgtcagatc acatgggcta 1860 aattttgcaa agaaaacatg gctggcaagg gcttctcctt ctgggtctgg ctggacaata 1920 tcattgacct tgtgaaaaag tacatcctgg ccctttggaa cgaagggtac atcatgggct 1980 ttatcagtaa ggagcgggag cgggccatct tgagcactaa gcctccaggc accttcctgc 2040 taagattcag tgaaagcagc aaagaaggag gcgtcacttt cacttgggtg gagaaggaca 2100 tcagcggtaa gacccagatc cagtccgtgg aaccatacac aaagcagcag ctgaacaaca 2160 tgtcatttgc tgaaatcatc atgggctata agatcatgga tgctaccaat atcctggtgt 2220 ctccactggt ctatctctat cctgacattc ccaaggagga ggcattcgga aagtattgtc 2280 ggccagagag ccaggagcat cctgaagctg acccaggcgc tgccccatac ctgaagacca 2340 agtttatctg tgtgacacca acgacctgca gcaataccat tgacctgccg atgtcccccc 2400 gcactttaga ttcattgatg cagtttggaa ataatggtga aggtgctgaa ccctcagcag 2460 gagggcagtt tgagtccctc acctttgaca tggagttgac ctcggagtgc gctacctccc 2520 ccatgtgagg agctgagaac ggaagctgca gaaagatacg actgaggcgc ctacctgcat 2580 tctgccaccc ctcacacagc caaaccccag atcatctgaa actactaact ttgtggttcc 2640 agattttttt taatctccta cttctgctat ctttgagcaa tctgggcact tttaaaaata 2700 gagaaatgag tgaatgtggg tgatctgctt ttatctaaat gcaaataagg atgtgttctc 2760 tgagacccat gatcagggga tgtggcgggg ggtggctaga gggagaaaaa ggaaatgtct 2820 tgtgttgttt tgttcccctg ccctcctttc tcagcagctt tttgttattg ttgttgttgt 2880 tcttagacaa gtgcctcctg gtgcctgcgg catccttctg cctgtttctg taagcaaatg 2940 ccacaggcca cctatagcta catactcctg gcattgcact ttttaacctt gctgacatcc 3000 aaatagaaga taggactatc taagccctag gtttcttttt aaattaagaa ataataacaa 3060 ttaaagggca aaaaacactg tatcagcata gcctttctgt atttaagaaa cttaagcagc 3120 cgggcatggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc ggatcataag 3180 gtcaggagat caagaccatc ctggctaaca cggtgaaacc ccgtctctac taaaagtaca 3240 aaaaattagc tgggtgtggt ggtgggcgcc tgtagtccca gctactcggg aggctgaggc 3300 aggagaatcg cttgaacctg agaggcggag gttgcagtga gccaaaattg caccactgca 3360 cactgcactc catcctgggc gacagtctga gactctgtct caaaaaaaaa aaaaaaaaaa 3420 agaaacttca gttaacagcc tccttggtgc tttaagcatt cagcttcctt caggctggta 3480 atttatataa tccctgaaac gggcttcagg tcaaaccctt aagacatctg aagctgcaac 3540 ctggcctttg gtgttgaaat aggaaggttt aaggagaatc taagcatttt agactttttt 3600 ttataaatag acttattttc ctttgtaatg tattggcctt ttagtgagta aggctgggca 3660 gagggtgctt acaaccttga ctccctttct ccctggactt gatctgctgt ttcagaggct 3720 aggttgtttc tgtgggtgcc ttatcagggc tgggatactt ctgattctgg cttccttcct 3780 gccccaccct cccgacccca gtccccctga tcctgctaga ggcatgtctc cttgcgtgtc 3840 taaaggtccc tcatcctgtt tgttttagga atcctggtct caggacctca tggaagaaga 3900 gggggagaga gttacaggtt ggacatgatg cacactatgg ggccccagcg acgtgtctgg 3960 ttgagctcag ggaatatggt tcttagccag tttcttggtg atatccagtg gcacttgtaa 4020 tggcgtcttc attcagttca tgcagggcaa aggcttactg ataaacttga gtctgccctc 4080 gtatgagggt gtatacctgg cctccctctg aggctggtga ctcctccctg ctggggcccc 4140 acaggtgagg cagaacagct agagggcctc cccgcctgcc cgccttggct ggctagctcg 4200 cctctcctgt gcgtatggga acacctagca cgtgctggat gggctgcctc tgactcagag 4260 gcatggccgg atttggcaac tcaaaaccac cttgcctcag ctgatcagag tttctgtgga 4320 attctgtttg ttaaatcaaa ttagctggtc tctgaattaa gggggagacg accttctcta 4380 agatgaacag ggttcgcccc agtcctcctg cctggagaca gttgatgtgt catgcagagc 4440 tcttacttct ccagcaacac tcttcagtac ataataagct taactgataa acagaatatt 4500 tagaaaggtg agacttgggc ttaccattgg gtttaaatca tagggaccta gggcgagggt 4560 tcagggcttc tctggagcag atattgtcaa gttcatggcc ttaggtagca tgtatctggt 4620 cttaactctg attgtagcaa aagttctgag aggagctgag ccctgttgtg gcccattaaa 4680 gaacagggtc ctcaggccct gcccgcttcc tgtccactgc cccctcccca tccccagccc 4740 agccgaggga atcccgtggg ttgcttacct acctataagg tggtttataa gctgctgtcc 4800 tggccactgc attcaaattc caatgtgtac ttcatagtgt aaaaatttat attattgtga 4860 ggttttttgt cttttttttt tttttttttt tttggtatat tgctgtatct actttaactt 4920 ccagaaataa acgttatata ggaaccgtaa aaa 4953 <210> 4 <211> 5243 <212> DNA <213> Homo sapiens <400> 4 agcgtgagac tcgcgccctc cggcacggaa aaggccaggc gacaggtgtc gcttgaaaag 60 actgggcttg tccttgctgg tgcatgcgtc gtcggcctct gggcagcagg tttacaaagg 120 aggaaaacga cttcttctag attttttttt cagtttcttc tataaatcaa aacatctcaa 180 aatggagacc taaaatcctt aaagggactt agtctaatct cgggaggtag ttttgtgcat 240 gggtaaacaa attaagtatt aactggtgtt ttactatcca aagaatgcta attttataaa 300 catgatcgag ttatataagg tataccataa tgagtttgat tttgaatttg atttgtggaa 360 ataaaggaaa agtgattcta gctggggcat attgttaaag catttttttc agagttggcc 420 aggcagtctc ctactggcac attctcccat tatgtagaat agaaatagta cctgtgtttg 480 ggaaagattt taaaatgagt gacagttatt tggaacaaag agctaataat caatccactg 540 caaattaaag aaacatgcag atgaaagttt tgacacatta aaatacttct acagtgacaa 600 agaaaaatca agaacaaagc tttttgatat gtgcaacaaa tttagaggaa gtaaaaagat 660 aaatgtgatg attggtcaag aaattatcca gttatttaca aggccactga tattttaaac 720 gtccaaaagt ttgtttaaat gggctgttac cgctgagaat gatgaggatg agaatgatgg 780 ttgaaggtta cattttagga aatgaagaaa cttagaaaat taatataaag acagtgatga 840 atacaaagaa gatttttata acaatgtgta aaatttttgg ccagggaaag gaatattgaa 900 gttagataca attacttacc tttgagggaa ataattgttg gtaatgagat gtgatgtttc 960 tcctgccacc tggaaacaaa gcattgaagt ctgcagttga aaagcccaac gtctgtgaga 1020 tccaggaaac catgcttgca aaccactggt aaaaaaaaaa aaaaaaaaaa aaaaaagcca 1080 cagtgacttg cttattggtc attgctagta ttatcgactc agaacctctt tactaatggc 1140 tagtaaatca taattgagaa attctgaatt ttgacaaggt ctctgctgtt gaaatggtaa 1200 atttattatt ttttttgtca tgataaattc tggttcaagg tatgctatcc atgaaataat 1260 ttctgaccaa aactaaattg atgcaatttg attatccatc ttagcctaca gatggcatct 1320 ggtaactttt gactgtttta aaaaataaat ccactatcag agtagatttg atgttggctt 1380 cagaaacatt tagaaaaaca aaagttcaaa aatgttttca ggaggtgata agttgaataa 1440 ctctacaatg ttagttcttt gagggggaca aaaaatttaa aatctttgaa aggtcttatt 1500 ttacagccat atctaaatta tcttaagaaa atttttaaca aagggaatga aatatatatc 1560 atgattctgt ttttccaaaa gtaacctgaa tatagcaatg aagttcagtt ttgttattgg 1620 tagtttgggc agagtctctt tttgcagcac ctgttgtcta ccataattac agaggacatt 1680 tccatgttct agccaagtat actattagaa taaaaaaact taacattgag ttgcttcaac 1740 agcatgaaac tgagtccaaa agaccaaatg aacaaacaca ttaatctctg attatttatt 1800 ttaaatagaa tatttaattg tgtaagatct aatagtatca ttatacttaa gcaatcatat 1860 tcctgatgat ctatgggaaa taactattat ttaattaata ttgaaaccag gttttaagat 1920 gtgttagcca gtcctgttac tagtaaatct ctttatttgg agagaaattt tagattgttt 1980 tgttctcctt attagaagga ttgtagaaag aaaaaaatga ctaattggag aaaaattggg 2040 gatatatcat atttcactga attcaaaatg tcttcagttg taaatcttac cattatttta 2100 cgtacctcta agaaataaaa gtgcttctaa ttaaaatatg atgtcattaa ttatgaaata 2160 cttcttgata acagaagttt taaaatagcc atcttagaat cagtgaaata tggtaatgta 2220 ttattttcct cctttgagtt aggtcttgtg cttttttttc ctggccacta aatttcacaa 2280 tttccaaaaa gcaaaataaa catattctga atatttttgc tgtgaaacac ttgacagcag 2340 agctttccac catgaaaaga agcttcatga gtcacacatt acatctttgg gttgattgaa 2400 tgccactgaa acattctagt agcctggaga agttgaccta cctgtggaga tgcctgccat 2460 taaatggcat cctgatggct taatacacat cactcttctg tgaagggttt taattttcaa 2520 cacagcttac tctgtagcat catgtttaca ttgtatgtat aaagattata caaaggtgca 2580 attgtgtatt tcttccttaa aatgtatcag tataggattt agaatctcca tgttgaaact 2640 ctaaatgcat agaaataaaa ataataaaaa atttttcatt ttggcttttc agcctagtat 2700 taaaactgat aaaagcaaag ccatgcacaa aactacctcc ctagagaaag gctagtccct 2760 tttcttcccc attcatttca ttatgaacat agtagaaaac agcatattct tatcaaattt 2820 gatgaaaagc gccaacacgt ttgaactgaa atacgacttg tcatgtgaac tgtaccgaat 2880 gtctacgtat tccacttttc ctgctggggt tcctgtctca gaaaggagtc ttgctcgtgc 2940 tggtttctat tacactggtg tgaatgacaa ggtcaaatgc ttctgttgtg gcctgatgct 3000 ggataactgg aaaagaggag acagtcctac tgaaaagcat aaaaagttgt atcctagctg 3060 cagattcgtt cagagtctaa attccgttaa caacttggaa gctacctctc agcctacttt 3120 tccttcttca gtaacaaatt ccacacactc attacttccg ggtacagaaa acagtggata 3180 tttccgtggc tcttattcaa actctccatc aaatcctgta aactccagag caaatcaaga 3240 tttttctgcc ttgatgagaa gttcctacca ctgtgcaatg aataacgaaa atgccagatt 3300 acttactttt cagacatggc cattgacttt tctgtcgcca acagatctgg caaaagcagg 3360 cttttactac ataggacctg gagacagagt ggcttgcttt gcctgtggtg gaaaattgag 3420 caattgggaa ccgaaggata atgctatgtc agaacacctg agacattttc ccaaatgccc 3480 atttatagaa aatcagcttc aagacacttc aagatacaca gtttctaatc tgagcatgca 3540 gacacatgca gcccgcttta aaacattctt taactggccc tctagtgttc tagttaatcc 3600 tgagcagctt gcaagtgcgg gtttttatta tgtgggtaac agtgatgatg tcaaatgctt 3660 ttgctgtgat ggtggactca ggtgttggga atctggagat gatccatggg ttcaacatgc 3720 caagtggttt ccaaggtgtg agtacttgat aagaattaaa ggacaggagt tcatccgtca 3780 agttcaagcc agttaccctc atctacttga acagctgcta tccacatcag acagcccagg 3840 agatgaaaat gcagagtcat caattatcca ttttgaacct ggagaagacc attcagaaga 3900 tgcaatcatg atgaatactc ctgtgattaa tgctgccgtg gaaatgggct ttagtagaag 3960 cctggtaaaa cagacagttc agagaaaaat cctagcaact ggagagaatt atagactagt 4020 caatgatctt gtgttagact tactcaatgc agaagatgaa ataagggaag aggagagaga 4080 aagagcaact gaggaaaaag aatcaaatga tttattatta atccggaaga atagaatggc 4140 actttttcaa catttgactt gtgtaattcc aatcctggat agtctactaa ctgccggaat 4200 tattaatgaa caagaacatg atgttattaa acagaagaca cagacgtctt tacaagcaag 4260 agaactgatt gatacgattt tagtaaaagg aaatattgca gccactgtat tcagaaactc 4320 tctgcaagaa gctgaagctg tgttatatga gcatttattt gtgcaacagg acataaaata 4380 tattcccaca gaagatgttt cagatctacc agtggaagaa caattgcgga gactacaaga 4440 agaaagaaca tgtaaagtgt gtatggacaa agaagtgtcc atagtgttta ttccttgtgg 4500 tcatctagta gtatgcaaag attgtgctcc ttctttaaga aagtgtccta tttgtaggag 4560 tacaatcaag ggtacagttc gtacatttct ttcatgaaga agaaccaaaa catcgtctaa 4620 actttagaat taatttatta aatgtattat aactttaact tttatcctaa tttggtttcc 4680 ttaaaatttt tatttattta caactcaaaa aacattgttt tgtgtaacat atttatatat 4740 gtatctaaac catatgaaca tatatttttt agaaactaag agaatgatag gcttttgttc 4800 ttatgaacga aaaagaggta gcactacaaa cacaatattc aatcaaaatt tcagcattat 4860 tgaaattgta agtgaagtaa aacttaagat atttgagtta acctttaaga attttaaata 4920 ttttggcatt gtactaatac cgggaacatg aagccaggtg tggtggtatg tgcctgtagt 4980 cccaggctga ggcaagagaa ttacttgagc ccaggagttt gaatccatcc tgggcagcat 5040 actgagaccc tgcctttaaa aacaaacaga acaaaaacaa aacaccaggg acacatttct 5100 ctgtcttttt tgatcagtgt cctatacatc gaaggtgtgc atatatgttg aatgacattt 5160 tagggacatg gtgtttttat aaagaattct gtgagaaaaa atttaataaa gcaacaaaaa 5220 ttactcttaa aaaaaaaaaa aaa 5243 <210> 5 <211> 3796 <212> DNA <213> Homo sapiens <400> 5 ctggtctggc cggcgacgcg cgtgccctgt ggccaaacac tgcctggagt gagagcaaac 60 taccagcgca gtggggccgg cgcgagtgtg cgtgtgtgtg cgtgtgtgtg tgcgagcgcg 120 gtggaggggg gggaccaact gcttcacact ttcaacactg cactgaagag ggagagcgag 180 agagagactg gagacgcaca gatcccccca aggtctccca agcctaccgt cccacagatt 240 attgtacaga gccccaaaaa tcgaaacaga ggaaacgaac agcagttgaa catggacgaa 300 ggaattcctc atttgcaaga gagacagtta ctggaacata gagattttat aggactggac 360 tattcctctt tgtatatgtg taaacccaaa aggagcatga aacgagacga caccaaggat 420 acctacaaat taccgcacag attaatagaa aagaaaagaa gagaccgaat taatgaatgc 480 attgctcagc tgaaagattt actgcctgaa catctgaaat tgacaactct gggacatctg 540 gagaaagctg tagtcttgga attaactttg aaacacttaa aagctttaac cgccttaacc 600 gagcaacagc atcagaagat aattgcttta cagaatgggg agcgatctct gaaatcgccc 660 attcagtccg acttggatgc gttccactcg ggatttcaaa catgcgccaa agaagtcttg 720 caatacctct cccggtttga gagctggaca cccagggagc cgcggtgtgt ccagctgatc 780 aaccacttgc acgccgtggc cacccagttc ttgcccaccc cgcagctgtt gactcaacag 840 gtccctctga gcaaaggcac cggcgctccc tcggccgccg ggtccgcggc cgccccctgc 900 ctggagcgcg cggggcagaa gctggagccc ctcgcctact gcgtgcccgt catccagcgg 960 actcagccca gcgccgagct cgccgccgag aacgacacgg acaccgacag cggctacggc 1020 ggcgaagccg aggcccggcc ggaccgcgag aaaggcaaag gcgcgggggc gagccgcgtc 1080 accatcaagc aggagcctcc cggggaggac tcgccggcgc ccaagaggat gaagctggat 1140 tcccgcggcg gcggcagcgg cggcggcccg gggggcggcg cggcggcggc ggcagccgcg 1200 cttctggggc ccgaccctgc cgccgcggcc gcgctgctga gacccgacgc cgccctgctc 1260 agctcgctgg tggcgttcgg cggaggcgga ggcgcgccct tcccgcagcc cgcggccgcc 1320 gcggccccct tctgcctgcc cttctgcttc ctctcgcctt ctgcagctgc cgcctacgtg 1380 cagcccttcc tggacaagag cggcctggag aagtatctgt acccggcggc ggctgccgcc 1440 ccgttcccgc tgctataccc cggcatcccc gccccggcgg cagccgcggc agccgccgcc 1500 gccgctgccg ccgccgccgc cgcgttcccc tgcctgtcct cggtgttgtc gccccctccc 1560 gagaaggcgg gcgccgccgc cgcgaccctc ctgccgcacg aggtggcgcc ccttggggcg 1620 ccgcaccccc agcacccgca cggccgcacc cacctgccct tcgccgggcc ccgcgagccg 1680 gggaacccgg agagctctgc tcaggaagat ccctcgcagc caggaaagga agctccctga 1740 atccttgcgt cccgaaggac ggaggttcaa gcagagtgag aagttaaaat acccttaagg 1800 aggttcaagc agagtgagaa gttaaaatac ccttaaggtc tttaagggag gaagtgtaat 1860 agatgcacga caggcataaa caagaacaac aaaacaggtg ttatgtgtac attcggagtt 1920 cctgttttgc tcatcccgca ccaccccacc ctccacacac taacatccct ttcttccccc 1980 caccagctgt aaaagatcct atgcgaaaga cactggctct tttttttaat cccccaaata 2040 aattttgccc ccttttaggc catgttccat tatctcttaa aattggaacc taattcgaga 2100 ggaagtaaga agggtctgtt ctgtggctga gctaggtgaa ccccggggta ggggaaagat 2160 gttaacacct ttgacgtctt tggagttgac atggaacagc aggtagttgt tatgtagagc 2220 tagttctcaa agctgccctg cctgttttag gaggcgttcc acaaacagat tgaggctctt 2280 ttagaattga atttactctt cagtattttc taatgttcag ctttctaaaa ggcatatatt 2340 tttcaaagaa gtgaggatgc agtttctcac gttgcaacct attctgaagt ggtttaaatg 2400 gtatctctta gtaacttgca ctcgttaaag aaacacggag ctgggccatc gtcagaacta 2460 agtcagggaa ggagatggat gagaaggcca gaatcattcc tagtacattt gctaacactt 2520 tattgagaaa ttgaccatga attaatggac tcatcttaat ttcttctaag tccatatata 2580 gatagatatc tatctgtaca gatttctatt tatccataga taggtatcta tacatacaca 2640 tctcaagtgc atctattccc actctcatta atccatcatg ttcctaaatt tttgtaatct 2700 tactgtaaaa aaaagtgcac tgaacttcaa aacaaaacaa aaaacaacaa caacaaaaaa 2760 caagtccaaa ctgatatatc ctatattctg ttaaaattca aaagtgaacg aaagcattta 2820 actggccagt tttgattgca aatgctgtaa agatatagaa tgaagtcctg tgaggccttc 2880 ctatctccaa gtctatgtat tttctggaga ccaaaccaga taccagataa tcacaaagaa 2940 agctttttta ataaggctta aaccaagacc ttgtctagat atttttagtt tgttgccaag 3000 gtagcactgt gagaaatctc acttggatgt tatgtaaggg gtgagacaca acagtctgac 3060 tatgagtgag gaaaatatct gggtcttttc gtcagtttgg tgcatttgct gctgctgttg 3120 ctactgtttg cctcaaacgc tgtgtttaaa caacgttaaa ctcttagcct acaaggtggc 3180 tcttatgtac atagttgtta atacatccaa ttaatgatgt ctgacatgct atttttgtag 3240 ggagaaaata tgtgctaatg atattttgag ttaaaatatc ttttggggag gatttgctga 3300 aaagttgcac ttttgttaca atgcttatgc ttggtacaag cttatgctgt cttaaattat 3360 tttaaaaaaa taaatactgt ctgtgagaaa ccagctggtt tagaaaagtt tagtatgtga 3420 cgataaacta gaaattacct ttatattcta gtattttcag cactccataa attctattac 3480 ctaaatattg ccacactatt ttgtgattta aaaattctta ctaaggaata aaaactttaa 3540 tatacgatat gatattgtct aataattaaa aaagacataa tggatgctca attagtttta 3600 agatatctat aactataggg atacaaatca ctacagttct cagatttaca gctttttttt 3660 gtcattggct tgatgtcaca catttccaat ctcttgcaag cctccaggct ctggctttgt 3720 ctacctgctc gttcccaatg tatcttaatg aaaagtgcaa aagaaaaacc taccaattaa 3780 aaaaaaaaaa aaaaaa 3796 <210> 6 <211> 3549 <212> DNA <213> Homo sapiens <400> 6 acatctggcg gctgccctcc cttgtttccg ctgcatccag acttcctcag gcggtggctg 60 gaggctgcgc atctggggct ttaaacatac aaagggattg ccaggacctg cggcggcggc 120 ggcggcggcg ggggctgggg cgcgggggcc ggaccatgag ccgctgagcc gggcaaaccc 180 caggccaccg agccagcgga ccctcggagc gcagccctgc gccgcggagc aggctccaac 240 caggcggcga ggcggccaca cgcaccgagc cagcgacccc cgggcgacgc gcggggccag 300 ggagcgctac gatggaggcg ctaatggccc ggggcgcgct cacgggtccc ctgagggcgc 360 tctgtctcct gggctgcctg ctgagccacg ccgccgccgc gccgtcgccc atcatcaagt 420 tccccggcga tgtcgccccc aaaacggaca aagagttggc agtgcaatac ctgaacacct 480 tctatggctg ccccaaggag agctgcaacc tgtttgtgct gaaggacaca ctaaagaaga 540 tgcagaagtt ctttggactg ccccagacag gtgatcttga ccagaatacc atcgagacca 600 tgcggaagcc acgctgcggc aacccagatg tggccaacta caacttcttc cctcgcaagc 660 ccaagtggga caagaaccag atcacataca ggatcattgg ctacacacct gatctggacc 720 cagagacagt ggatgatgcc tttgctcgtg ccttccaagt ctggagcgat gtgaccccac 780 tgcggttttc tcgaatccat gatggagagg cagacatcat gatcaacttt ggccgctggg 840 agcatggcga tggatacccc tttgacggta aggacggact cctggctcat gccttcgccc 900 caggcactgg tgttggggga gactcccatt ttgatgacga tgagctatgg accttgggag 960 aaggccaagt ggtccgtgtg aagtatggga acgccgatgg ggagtactgc aagttcccct 1020 tcttgttcaa tggcaaggag tacaacagct gcactgatac cggccgcagc gatggcttcc 1080 tctggtgctc caccacctac aactttgaga aggatggcaa gtacggcttc tgtccccatg 1140 aagccctgtt caccatgggc ggcaacgctg aaggacagcc ctgcaagttt ccattccgct 1200 tccagggcac atcctatgac agctgcacca ctgagggccg cacggatggc taccgctggt 1260 gcggcaccac tgaggactac gaccgcgaca agaagtatgg cttctgccct gagaccgcca 1320 tgtccactgt tggtgggaac tcagaaggtg ccccctgtgt cttccccttc actttcctgg 1380 gcaacaaata tgagagctgc accagcgccg gccgcagtga cggaaagatg tggtgtgcga 1440 ccacagccaa ctacgatgat gaccgcaagt ggggcttctg ccctgaccaa gggtacagcc 1500 tgttcctcgt ggcagcccac gagtttggcc acgccatggg gctggagcac tcccaagacc 1560 ctggggccct gatggcaccc atttacacct acaccaagaa cttccgtctg tcccaggatg 1620 acatcaaggg cattcaggag ctctatgggg cctctcctga cattgacctt ggcaccggcc 1680 ccacccccac gctgggccct gtcactcctg agatctgcaa acaggacatt gtatttgatg 1740 gcatcgctca gatccgtggt gagatcttct tcttcaagga ccggttcatt tggcggactg 1800 tgacgccacg tgacaagccc atggggcccc tgctggtggc cacattctgg cctgagctcc 1860 cggaaaagat tgatgcggta tacgaggccc cacaggagga gaaggctgtg ttctttgcag 1920 ggaatgaata ctggatctac tcagccagca ccctggagcg agggtacccc aagccactga 1980 ccagcctggg actgccccct gatgtccagc gagtggatgc cgcctttaac tggagcaaaa 2040 acaagaagac atacatcttt gctggagaca aattctggag atacaatgag gtgaagaaga 2100 aaatggatcc tggcttcccc aagctcatcg cagatgcctg gaatgccatc cccgataacc 2160 tggatgccgt cgtggacctg cagggcggcg gtcacagcta cttcttcaag ggtgcctatt 2220 acctgaagct ggagaaccaa agtctgaaga gcgtgaagtt tggaagcatc aaatccgact 2280 ggctaggctg ctgagctggc cctggctccc acaggccctt cctctccact gccttcgata 2340 caccgggcct ggagaactag agaaggaccc ggaggggcct ggcagccgtg ccttcagctc 2400 tacagctaat cagcattctc actcctacct ggtaatttaa gattccagag agtggctcct 2460 cccggtgccc aagaatagat gctgactgta ctcctcccag gcgccccttc cccctccaat 2520 cccaccaacc ctcagagcca cccctaaaga gatactttga tattttcaac gcagccctgc 2580 tttgggctgc cctggtgctg ccacacttca ggctcttctc ctttcacaac cttctgtggc 2640 tcacagaacc cttggagcca atggagactg tctcaagagg gcactggtgg cccgacagcc 2700 tggcacaggg cagtgggaca gggcatggcc aggtggccac tccagacccc tggcttttca 2760 ctgctggctg ccttagaacc tttcttacat tagcagtttg ctttgtatgc actttgtttt 2820 tttctttggg tcttgttttt tttttccact tagaaattgc atttcctgac agaaggactc 2880 aggttgtctg aagtcactgc acagtgcatc tcagcccaca tagtgatggt tcccctgttc 2940 actctactta gcatgtccct accgagtctc ttctccactg gatggaggaa aaccaagccg 3000 tggcttcccg ctcagccctc cctgcccctc ccttcaacca ttccccatgg gaaatgtcaa 3060 caagtatgaa taaagacacc tactgagtgg ccgtgtttgc catctgtttt agcagagcct 3120 agacaagggc cacagaccca gccagaagcg gaaacttaaa aagtccgaat ctctgctccc 3180 tgcagggcac aggtgatggt gtctgctgga aaggtcagag cttccaaagt aaacagcaag 3240 agaacctcag ggagagtaag ctctagtccc tctgtcctgt agaaagagcc ctgaagaatc 3300 agcaattttg ttgctttatt gtggcatctg ttcgaggttt gcttcctctt taagtctgtt 3360 tcttcattag caatcatatc agttttaatg ctactactaa caatgaacag taacaataat 3420 atccccctca attaatagag tgctttctat gtgcaaggca cttttcacgt gtcacctatt 3480 ttaacctttc caaccacata aataaaaaag gccattatta gttgaaaaaa aaaaaaaaaa 3540 aaaaaaaaa 3549 <210> 7 <211> 3503 <212> DNA <213> Homo sapiens <400> 7 gctggtgtca gagcccggcg agcgctggca gttccgcggc ggggatgctg aggagcgctg 60 ggtccgggag cagccctggc ccctgcggac ttccgaggcc gtgaaaaccc ctgcgctgcg 120 gcccttccca ggcccccgag gccgttcgcc gttcccgaag cccgactggg ggaagagtcc 180 agcaccaaag cggccgttct cggattccgg agcgttctgg agccccgaga gacgccccgg 240 ggttctagaa gctccccggc ggcgcccagt cccggcttca ttcgggcgtc cctccgaaac 300 ccactcgggt gcacgggtcg tcggcgagcc gcgaccgggt cctggcgcgc accatgatcg 360 tggcggactc cgagtgccgc gcagagctca aggactacct gcggttcgcc ccgggcggcg 420 tcggcgactc gggccccgga gaggagcaga gggagagccg ggctcggcga ggccctcgag 480 ggcccagcgc cttcatcccc gtggaggagg tccttcggga gggggctgag agcctcgagc 540 agcacctggg gctggaggca ctgatgtcct ctgggcgagt agacaacctg gcagtggtga 600 tgggcctgca ccctgactac tttaccagct tctggcgcct gcactacctg ctgctgcaca 660 cggatggtcc cttggccagc tcctggcgcc actacattgc catcatggct gccgcccgcc 720 atcagtgttc ttacctggta ggctcccaca tggccgagtt tctgcagact ggtggtgacc 780 ctgagtggct gctgggcctc caccgggccc ccgagaagct gcgcaaactc agcgagatca 840 acaagttgct ggcgcatcgg ccatggctca tcaccaagga acacatccag gccttgctga 900 agaccggcga gcacacttgg tccctggccg agctcattca ggctctggtc ctgctcaccc 960 actgccactc gctctcctcc ttcgtgtttg gctgtggcat cctccctgag ggggatgcag 1020 atggcagccc tgccccccag gcacctacac cccctagtga acagagcagc cccccaagca 1080 gggacccgtt gaacaactct gggggctttg agtctgcccg cgacgtggag gcgctgatgg 1140 agcgcatgca gcagctgcag gagagcctgc tgcgggatga ggggacgtcc caggaggaga 1200 tggagagccg ctttgagctg gagaagtcag agagcctgct ggtgaccccc tcagctgaca 1260 tcctggagcc ctctccacac ccagacatgc tgtgctttgt ggaagaccct actttcggat 1320 atgaggactt cactcggaga ggggctcagg caccccctac cttccgggcc caggattata 1380 cctgggaaga ccatggctac tcgctgatcc agcggcttta ccctgagggt gggcagctgc 1440 tggatgagaa gttccaggca gcctatagcc tcacctacaa taccatcgcc atgcacagtg 1500 gtgtggacac ctccgtgctc cgcagggcca tctggaacta tatccactgc gtctttggca 1560 tcagatatga tgactatgat tatggggagg tgaaccagct cctggagcgg aacctcaagg 1620 tctatatcaa gacagtggcc tgctacccag agaagaccac ccgaagaatg tacaacctct 1680 tctggaggca cttccgccac tcagagaagg tccacgtgaa cttgctgctc ctggaggcgc 1740 gcatgcaagc cgctctgctg tacgccctcc gtgccatcac ccgctacatg acctgactcc 1800 tgagcaggac ctgggcccgg ttcagctccc cacaaggact tctctgtctg gagacagccc 1860 cagacccttt tgtgtcccat gcccaccctc cccacgctgc agtgggcttg tgtgtgatgt 1920 gcagtcccga agccacaccc tcccttttcc tcactggaat ggacagttca ttgcactgac 1980 tctgggatct cagccctgct cctgggagct ggaagagcac ttggagatcc taagggacca 2040 cacccttcct ccttcccctg cccacagagg cagagggcac aggaaagaag ccgggccaag 2100 ctcggaatta atgtgccaca agtgttgtgg ccttcctgaa ctgggaagtc cctggctggc 2160 ccccggggga gaggggcaaa tgcctccggg actgacactc caggcagctt tgccttctct 2220 cccctgtcat ttccagattt cattacctcc tacttgccat tcacccatca atgtgaaagt 2280 cagggtcaca gctggtctgt gtgtccagtt ccctaaaagc ctgttctgtt gggcagcctg 2340 aggctgttgc ccgaatccta gttcagtttt ttgacttcct ttgccctttt tcccttttct 2400 ccatgcttaa tggtgtgagg cgtcaggaga gaggccaagt acataaaaaa aaaaaaagca 2460 gattatctct agagagtttg agcctttgct ggtcacattg ccttctgaag aggagggagt 2520 attagattat aaatcctctt tattttggtc ctttatgctt gaggttccaa cctggagcca 2580 cagtgtgtga gaggaggagg agagggagaa ttctgttctc ccagagctgc acctgcctcg 2640 cagaggccag caccccactc tcctgcctcc agtggccctg ccgcagatgt ctcccaaaaa 2700 gttgagcctt tctagatggc ttaggtggca ccatggctca gcaggagggg cgggaggcac 2760 cagggttctt gtttggaccc tgcccctggg ccatggccag gtgaccatgg ctacattgcc 2820 aaacctctga ctgccacagc tgcagactga gagggtgggt ctgagtcccc acaatgtctg 2880 aagctgcccc tgggattctc aggccaacct gccaacagca agcggatttt cttgcaagat 2940 cagggacccc atttctgcag ccagtgtctc ctgggtgcct tctgaggact cccaccccca 3000 tcccagtatc tcatctgtcc cctctcctgg ggcttaagtg ggttgcttcc aggcagaagc 3060 agccaaggac cgattccagg cactttctgt agcaaatgac tgtgaattac gacttctctt 3120 gcccttcttc tagcagtctg tgcctcctct ctgaccagtt tggagggcac tgaagaaagg 3180 caagggccgt gctgctgctg ggcggggcag gagaggagcc tggccagtgt gccacattaa 3240 atacccgtgc aggcgcggag aagcaaccgg cacccccttc cggcctgaaa gccctccctg 3300 caagaaggtg tgcaggagag aagaggcccc ggcatgggga tctgggttct agagggcatg 3360 tgatgactgt aaatgttcac tgggtgggta gggagtggta tccagtgttc aagtgcagaa 3420 atctttggct ttgctaccag ttccatatga tgagaaataa acgttcgctg aggttttgtt 3480 tcataaaaaa aaaaaaaaaa aaa 3503 <210> 8 <211> 3428 <212> DNA <213> Homo sapiens <400> 8 tggagagtaa tgttacagag cggagagagt gaggaggctg cgtctggctc ccgctctcac 60 agccattgca gtacattgag ctccatagag acagcgccgg ggcaagtgag agccggacgg 120 gcactgggcg actctgtgcc tcgctgagga aaaataacta aacatgggca aaggagatcc 180 taagaagccg agaggcaaaa tgtcatcata tgcatttttt gtgcaaactt gtcgggagga 240 gcataagaag aagcacccag atgcttcagt caacttctca gagttttcta agaagtgctc 300 agagaggtgg aagaccatgt ctgctaaaga gaaaggaaaa tttgaagata tggcaaaagc 360 ggacaaggcc cgttatgaaa gagaaatgaa aacctatatc cctcccaaag gggagacaaa 420 aaagaagttc aaggatccca atgcacccaa gaggcctcct tcggccttct tcctcttctg 480 ctctgagtat cgcccaaaaa tcaaaggaga acatcctggc ctgtccattg gtgatgttgc 540 gaagaaactg ggagagatgt ggaataacac tgctgcagat gacaagcagc cttatgaaaa 600 gaaggctgcg aagctgaagg aaaaatacga aaaggatatt gctgcatatc gagctaaagg 660 aaagcctgat gcagcaaaaa agggagttgt caaggctgaa aaaagcaaga aaaagaagga 720 agaggaggaa gatgaggaag atgaagagga tgaggaggag gaggaagatg aagaagatga 780 agatgaagaa gaagatgatg atgatgaata agttggttct agcgcagttt tttttttctt 840 gtctataaag catttaaccc ccctgtacac aactcactcc ttttaaagaa aaaaattgaa 900 atgtaaggct gtgtaagatt tgtttttaaa ctgtacagtg tctttttttg tatagttaac 960 acactaccga atgtgtcttt agatagccct gtcctggtgg tattttcaat agccactaac 1020 cttgcctggt acagtatggg ggttgtaaat tggcatggaa atttaaagca ggttcttgtt 1080 ggtgcacagc acaaattagt tatatatggg gatggtagtt ttttcatctt cagttgtctc 1140 tgatgcagct tatacgaaat aattgttgtt ctgttaactg aataccactc tgtaattgca 1200 aaaaaaaaaa aaaagttgca gctgttttgt tgacattctg aatgcttcta agtaaataca 1260 atttttttta ttagtattgt tgtccttttc ataggtctga aatttttctt cttgagggga 1320 agctagtctt ttgcttttgc ccattttgaa tcacatgaat tattacagtg tttatccttt 1380 catatagtta gctaataaaa agcttttgtc tacacaccct gcatatcata atgggggtaa 1440 agttaagttg agatagtttt catccataac tgaacatcca aaatcttgat cagttaagaa 1500 atttcacata gcccacttac atttacaaac tgaagagtaa tcaatctact caaagcatgg 1560 gattattaga atcaaacatt ttgaaagtct gtccttgaag gactaataga aaagtatgtt 1620 ctaaccttta catgaggact ctattcttta actcccatta ccatgtaatg gcagttatat 1680 tttgcagttc ccacattaaa gaagacctga gaatgtatcc ccaaaagcgt gagcttaaaa 1740 tacaagactg ccatattaaa ttttttgttg acattagtct cagtgaagac tatgaaaatg 1800 ctggctatag atgtcttttc ccatttatct aaatatggac tgctcaggaa acgagacttt 1860 ccattacaag tatttttaat taattgggcc agcttttcaa acaaagatgc cacattcaaa 1920 atagggtata ttttcctata ttacggtttg cccctttata aatccaagta gataggaaga 1980 aagaagacaa actttgcatc tcagtatgaa ttattcaatt tatttgaatg atttttcttt 2040 acaaaacaaa ctcattcatt agtcatgttt atctgcttag gagtttaggg aacaatttgg 2100 caattttgtg gttttcgaga ttatcgtttt cttaaagtgc cagtatttta aaatagcgtt 2160 cttgtaattt tacacgcttt tgtgatggag tgctgttttg ttatataatt tagacttgga 2220 ttctttccat ttgcatttgt ttatgtaatt tcaggaggaa tactgaacat ctgagtcctg 2280 gatgatacta ataaactaat aattgcagag gttttaaata ctagttaaat ggctttcact 2340 taagaactta agattttgtt acatattttt aaatcttgtt tctaataata cctcttagca 2400 gtacctttta aataagtata agggatggca aagtttttcc ctttaaaaat actcacttta 2460 tgcttataaa taggttaatg ggctgataaa aggttttgtc aaacattgca agtattcggt 2520 gctatatata aaggaggaaa aactagtttt actttcagaa tgatttaaac aagattttta 2580 aaaacaagat acatgcaagc gaacagcagg gttagtgata ggctgcaatt gtgtcgaaca 2640 tcagattttt tgttaagagg agcaaatgac tcaatctgat ttagatggaa gtttctactg 2700 tatagaaatc accattaatc accaacatta ataattctga tccatttaaa atgaattctg 2760 gctcaaggag aatttgtaac tttagtaggt acgtcatgac aactaccatt tttttaagat 2820 gttgagaatg ggaacagttt ttttagggtt tattcttgac cacagatctt aagaaaatgg 2880 acaaaacccc tcttcaatct gaagattagt atggtttggt gttctaacag tatcccctag 2940 aagttggatg tctaaaactc aagtaaatgg aagtgggagg caatttagat aagtgtaaag 3000 ccttgtaact gaagatgatt ttttttagaa agtgtataga aactatttta atgccaagat 3060 agttacagtg ctgtggggtt taaagacttt gttgacatca agaaaagact aaatctataa 3120 ttaattgggc caacttttaa aatgaagatg ctttttaaaa ctaatgaact aagatgtata 3180 aatcttagtt tttttgtatt ttaaagatag gcatatggca tattgattaa cgagtcaaat 3240 ttcctaactt tgctgtgcaa aggttgagag ctattgctga ttagttacca cagttctgat 3300 gatcgtccca tcacagtgtt gttaatgttt gctgtattta ttaattttct taaagtgaaa 3360 tctgaaaaat gaaatttgtg tgtcctgtgt acccgagggg taatgattaa atgataaaga 3420 taagaaaa 3428 <210> 9 <211> 4110 <212> DNA <213> Homo sapiens <400> 9 gtcgagcggg agcagaggag gcgagggagg agggccagag aggcagttgg aagatggcgg 60 acgaggcggc cctcgccctt cagcccggcg gctccccctc ggcggcgggg gccgacaggg 120 aggccgcgtc gtcccccgcc ggggagccgc tccgcaagag gccgcggaga gatggtcccg 180 gcctcgagcg gagcccgggc gagcccggtg gggcggcccc agagcgtgag gtgccggcgg 240 cggccagggg ctgcccgggt gcggcggcgg cggcgctgtg gcgggaggcg gaggcagagg 300 cggcggcggc aggcggggag caagaggccc aggcgactgc ggcggctggg gaaggagaca 360 atgggccggg cctgcagggc ccatctcggg agccaccgct ggccgacaac ttgtacgacg 420 aagacgacga cgacgagggc gaggaggagg aagaggcggc ggcggcggcg attgggtacc 480 gagataacct tctgttcggt gatgaaatta tcactaatgg ttttcattcc tgtgaaagtg 540 atgaggagga tagagcctca catgcaagct ctagtgactg gactccaagg ccacggatag 600 gtccatatac ttttgttcag caacatctta tgattggcac agatcctcga acaattctta 660 aagatttatt gccggaaaca atacctccac ctgagttgga tgatatgaca ctgtggcaga 720 ttgttattaa tatcctttca gaaccaccaa aaaggaaaaa aagaaaagat attaatacaa 780 ttgaagatgc tgtgaaatta ctgcaagagt gcaaaaaaat tatagttcta actggagctg 840 gggtgtctgt ttcatgtgga atacctgact tcaggtcaag ggatggtatt tatgctcgcc 900 ttgctgtaga cttcccagat cttccagatc ctcaagcgat gtttgatatt gaatatttca 960 gaaaagatcc aagaccattc ttcaagtttg caaaggaaat atatcctgga caattccagc 1020 catctctctg tcacaaattc atagccttgt cagataagga aggaaaacta cttcgcaact 1080 atacccagaa catagacacg ctggaacagg ttgcgggaat ccaaaggata attcagtgtc 1140 atggttcctt tgcaacagca tcttgcctga tttgtaaata caaagttgac tgtgaagctg 1200 tacgaggaga tatttttaat caggtagttc ctcgatgtcc taggtgccca gctgatgaac 1260 cgcttgctat catgaaacca gagattgtgt tttttggtga aaatttacca gaacagtttc 1320 atagagccat gaagtatgac aaagatgaag ttgacctcct cattgttatt gggtcttccc 1380 tcaaagtaag accagtagca ctaattccaa gttccatacc ccatgaagtg cctcagatat 1440 taattaatag agaacctttg cctcatctgc attttgatgt agagcttctt ggagactgtg 1500 atgtcataat taatgaattg tgtcataggt taggtggtga atatgccaaa ctttgctgta 1560 accctgtaaa gctttcagaa attactgaaa aacctccacg aacacaaaaa gaattggctt 1620 atttgtcaga gttgccaccc acacctcttc atgtttcaga agactcaagt tcaccagaaa 1680 gaacttcacc accagattct tcagtgattg tcacactttt agaccaagca gctaagagta 1740 atgatgattt agatgtgtct gaatcaaaag gttgtatgga agaaaaacca caggaagtac 1800 aaacttctag gaatgttgaa agtattgctg aacagatgga aaatccggat ttgaagaatg 1860 ttggttctag tactggggag aaaaatgaaa gaacttcagt ggctggaaca gtgagaaaat 1920 gctggcctaa tagagtggca aaggagcaga ttagtaggcg gcttgatggt aatcagtatc 1980 tgtttttgcc accaaatcgt tacattttcc atggcgctga ggtatattca gactctgaag 2040 atgacgtctt atcctctagt tcttgtggca gtaacagtga tagtgggaca tgccagagtc 2100 caagtttaga agaacccatg gaggatgaaa gtgaaattga agaattctac aatggcttag 2160 aagatgagcc tgatgttcca gagagagctg gaggagctgg atttgggact gatggagatg 2220 atcaagaggc aattaatgaa gctatatctg tgaaacagga agtaacagac atgaactatc 2280 catcaaacaa atcatagtgt aataattgtg caggtacagg aattgttcca ccagcattag 2340 gaactttagc atgtcaaaat gaatgtttac ttgtgaactc gatagagcaa ggaaaccaga 2400 aaggtgtaat atttataggt tggtaaaata gattgttttt catggataat ttttaacttc 2460 attatttctg tacttgtaca aactcaacac taactttttt ttttttaaaa aaaaaaaggt 2520 actaagtatc ttcaatcagc tgttggtcaa gactaacttt cttttaaagg ttcatttgta 2580 tgataaattc atatgtgtat atataatttt ttttgttttg tctagtgagt ttcaacattt 2640 ttaaagtttt caaaaagcca tcggaatgtt aaattaatgt aaagggaaca gctaatctag 2700 accaaagaat ggtattttca cttttctttg taacattgaa tggtttgaag tactcaaaat 2760 ctgttacgct aaacttttga ttctttaaca caattatttt taaacactgg cattttccaa 2820 aactgtggca gctaactttt taaaatctca aatgacatgc agtgtgagta gaaggaagtc 2880 aacaatatgt ggggagagca ctcggttgtc tttactttta aaagtaatac ttggtgctaa 2940 gaatttcagg attattgtat ttacgttcaa atgaagatgg cttttgtact tcctgtggac 3000 atgtagtaat gtctatattg gctcataaaa ctaacctgaa aaacaaataa atgctttgga 3060 aatgtttcag ttgctttaga aacattagtg cctgcctgga tccccttagt tttgaaatat 3120 ttgccattgt tgtttaaata cctatcactg tggtagagct tgcattgatc ttttccacaa 3180 gtattaaact gccaaaatgt gaatatgcaa agcctttctg aatctataat aatggtactt 3240 ctactgggga gagtgtaata ttttggactg ctgttttcca ttaatgagga gagcaacagg 3300 cccctgatta tacagttcca aagtaataag atgttaattg taattcagcc agaaagtaca 3360 tgtctcccat tgggaggatt tggtgttaaa taccaaactg ctagccctag tattatggag 3420 atgaacatga tgatgtaact tgtaatagca gaatagttaa tgaatgaaac tagttcttat 3480 aatttatctt tatttaaaag cttagcctgc cttaaaacta gagatcaact ttctcagctg 3540 caaaagcttc tagtctttca agaagttcat actttatgaa attgcacagt aagcatttat 3600 ttttcagacc atttttgaac atcactccta aattaataaa gtattcctct gttgctttag 3660 tatttattac aataaaaagg gtttgaaata tagctgttct ttatgcataa aacacccagc 3720 taggaccatt actgccagag aaaaaaatcg tattgaatgg ccatttccct acttataaga 3780 tgtctcaatc tgaatttatt tggctacact aaagaatgca gtatatttag ttttccattt 3840 gcatgatgtt tgtgtgctat agatgatatt ttaaattgaa aagtttgttt taaattattt 3900 ttacagtgaa gactgttttc agctcttttt atattgtaca tagtctttta tgtaatttac 3960 tggcatatgt tttgtagact gtttaatgac tggatatctt ccttcaactt ttgaaataca 4020 aaaccagtgt tttttacttg tacactgttt taaagtctat taaaattgtc atttgacttt 4080 tttctgttaa cttaaaaaaa aaaaaaaaaa 4110 <210> 10 <211> 952 <212> DNA <213> Homo sapiens <400> 10 ccacgcgtcc ggcacttccg cccatccccc tccggatccc tctgttcggg ctcgggtttc 60 cgccgagacg acagggactg ccaggtcgga agtagtgtga ggctcgtggg cggagccaag 120 cgccgccatg tccgccgccc tgctgcggcg gggcctggag ctgctggcgg cgtccgaggc 180 cccccgggac cctccaggtc aggccaagcc gagaggggct ccggtgaaac ggccccggaa 240 gacgaaggca attcaggccc agaaactgcg gaactcggcc aagggaaagg tgcccaagtc 300 ggcactggac gagtaccgga agcgagagtg tcgagaccac ctcagagtaa acctgaagtt 360 tctgaccagg acgagaagca ccgtggctga gtctgtgagc cagcagattt tgcgccagaa 420 ccggggccgc aaggcctgtg accggcctgt ggccaagacc aagaagaaga aggctgaggg 480 caccgtgttc accgaggaag acttccagaa gttccagcag gaatacttcg gcagctaggc 540 tccctggagg gcacggtgaa gaggccttca agccctgcag cctccgactc ctgctggctc 600 caggaaccgg ccgtgccgcg cggccagcag atggcgatgc aggaccagcc tggctcgagg 660 aagccgcgga gctgagccga gtggaggctg gaatggagct ggtgggccgg aagtcctggg 720 gaggatttac acacagaccg gagctggctt ccgcaggcct gggcagagca tctgcacctg 780 ccggaaagga acgtatctgt tttgtttgct tttgcccagg tggggcctct gggctgtttg 840 ctgtggagca aggctaattc ctgagccctt ggggacgaca gctccaggag taggaagaag 900 ggtgggcttc caagttacaa taaatgtgaa cccaagaaaa aaaaaaaaaa aa 952 <210> 11 <211> 6603 <212> DNA <213> Homo sapiens <400> 11 aagaaagagc cccgccccta gtcttatgac tcgcactgaa gcgccgattc ctggcttttg 60 caaggctgtg gtcggtggtc atcagtgctc ttgacccagg tccagcgagc cttttccctg 120 gtgttgcagc tgttgttgta ccgccgccgt cgccgccgtc gccgcctgct ctgcggggtc 180 atggtgtgct tccgcctctt cccggttccg ggctcagggc tcgttctggt ctgcctagtc 240 ctgggagctg tgcggtctta tgcattggaa cttaatttga cagattcaga aaatgccact 300 tgcctttatg caaaatggca gatgaatttc acagtacgct atgaaactac aaataaaact 360 tataaaactg taaccatttc agaccatggc actgtgacat ataatggaag catttgtggg 420 gatgatcaga atggtcccaa aatagcagtg cagttcggac ctggcttttc ctggattgcg 480 aattttacca aggcagcatc tacttattca attgacagcg tctcattttc ctacaacact 540 ggtgataaca caacatttcc tgatgctgaa gataaaggaa ttcttactgt tgatgaactt 600 ttggccatca gaattccatt gaatgacctt tttagatgca atagtttatc aactttggaa 660 aagaatgatg ttgtccaaca ctactgggat gttcttgtac aagcttttgt ccaaaatggc 720 acagtgagca caaatgagtt cctgtgtgat aaagacaaaa cttcaacagt ggcacccacc 780 atacacacca ctgtgccatc tcctactaca acacctactc caaaggaaaa accagaagct 840 ggaacctatt cagttaataa tggcaatgat acttgtctgc tggctaccat ggggctgcag 900 ctgaacatca ctcaggataa ggttgcttca gttattaaca tcaaccccaa tacaactcac 960 tccacaggca gctgccgttc tcacactgct ctacttagac tcaatagcag caccattaag 1020 tatctagact ttgtctttgc tgtgaaaaat gaaaaccgat tttatctgaa ggaagtgaac 1080 atcagcatgt atttggttaa tggctccgtt ttcagcattg caaataacaa tctcagctac 1140 tgggatgccc ccctgggaag ttcttatatg tgcaacaaag agcagactgt ttcagtgtct 1200 ggagcatttc agataaatac ctttgatcta agggttcagc ctttcaatgt gacacaagga 1260 aagtattcta cagctcaaga ctgcagtgca gatgacgaca acttccttgt gcccatagcg 1320 gtgggagctg ccttggcagg agtacttatt ctagtgttgc tggcttattt tattggtctc 1380 aagcaccatc atgctggata tgagcaattt tagaatctgc aacctgattg attatataaa 1440 aatacatgca aataacaaga ttttcttacc tctcagttgt tgaaacactt tgcttcttaa 1500 aattgatatg ttgaaacttt aattctttta tcaatcccag cattttgaga tcagtcttta 1560 ttaataaaac ctgttctctt taatcagctt aaaatccaaa gtgtcatatt tactggtcct 1620 ggagacaaac ttgttcaaaa gaacatcaac gtgcaatgtt ttaaggtcta tcttaagaag 1680 ccctggccaa attttgatcc taaccttgaa gtatgccttg aacttattaa catggccatt 1740 ataagaataa aatatgtagt tgtgtcttaa tggaattaat aaatgtcatt tcactactgg 1800 tgttctgttt caatgtataa ggactatagt gatttaaact catcaatgtg cctttgcata 1860 aagttcatta aataaatatt gatgtggtat aaatgcccat cagatatgct taaacttggt 1920 tttcagttga atgaagtaga gaatgtcctc aggaccatca gcattttaaa ggttatgtga 1980 cttttgctga tttctctgag ttcaagttaa gcatgaagtt agtacctcaa gcctgtgatt 2040 tttccctagg gatgatacag acccaagagg ctacaacaga acttaaactg gcttcgtaat 2100 tagagttttt aagataattg tttgtttttc agcaatatag actgaaaaga tccaagcata 2160 tttagccact tgcttttttg tttcttgttt tgttcttctt tggatgcctg attagtattg 2220 aaagatagaa atattctatg aactaattag gacagattgt gttgtgtttc tctacctcat 2280 cttgttgatc tctggagcat taaaatctat ttagtgttgt catcagtgtg gtacttatga 2340 aatgtaagct aacagcaatc tcagaaggga ggcagtgaag catagcaact aggctcttgt 2400 ttcttcaaga tggcccctgt ggggcagtgc atagatgggg gtgtaaagag aagctgttgg 2460 cattaaaatg agctagataa tcagcccttg ttgaagcata ttccatggta taagagtagc 2520 acagacatga aacatagata aagaaggaag gcttaataga ctagaagact tccacattga 2580 agtattatta acccattgta tgtatatagg ggcatgatca gagtctctat aacttcctga 2640 ttaacaatac agtgtatctt gttacccagc tgtcagtctt tgagagcttt cagtaaaata 2700 tagtaaattc tttcagcata ggctaatgtg tggttactga gatgagtgtt gtgtactcag 2760 aaccgtagca acatttttat gaatggtaaa agtacaagag gaggaaaagt taaaattaga 2820 agaaaagtac aagttattgc ttaatcataa atcacaccag ataacacatt ttgttaattt 2880 cattagctat tactggaaag gaccttaacg attatttaca gaaaggggag tgaaattcat 2940 tgaggttcca tatcaagtgg gcaacaaaac tattactagc attttgataa aaattgcccc 3000 taatgaaatc tagtcactca acagtaaaac aacagctggt ttacacttga aattatgaga 3060 tcagaattgg gcactttggg cttccgtact atgttttgct taagtttttt ttttaatact 3120 aatatgggct ttttcagtag taatatacca aaacacttct attttaatct ctgtttgcta 3180 cttcaaaacc taatcctcct cagatgggat catgagcata agaggaaaag agaagagaat 3240 gaatacttgt tgacctcttg atgtgtatca gatgctttag aaatgtaatt gtatttaatc 3300 ctcaaatacc ttataggtat tattatcccc ttcttacaga tgaggaaagt gaggcccagt 3360 ttaaataact tgcccaaggt cctttggcta gtactggaag gagtcaagat ttaaacacag 3420 ttctgtctga atccagaact caaaatctac attgcacatg ttgctttcct ggtggttcgg 3480 tggaatggac tgcaacgcat tagatactgc tgttattctt ccaggccacc gctcagctaa 3540 aaataattgt gtgtgtgtgt atatatatat atatgtacac acacacacat atatatacac 3600 acacacatat atatacacat atacatatat atacacatat atatacacac acatatatat 3660 gtatatatat actacattct tgatcctaag tcttttttaa cttaaatttt attacttata 3720 cagaattctt atttatactt taattatagg tgtgacgaag agaaagagag tagggaaata 3780 cacaggcagt ggttttaagt gtagatgatg gctccttaac ccagtgtcat tagataatca 3840 aacctaaagt cttcccatat taggcaagcg caattctcta ttttggaccc ttcccattct 3900 tcccttacct tctgcttttc gtactgagga atttcgtgtg attttagata aagtgataat 3960 gagatattga gcaaataaga aaatagaggt aatgctataa aaaactaagc tatgtacact 4020 ttcaaaatgc atgtttcttg catgcttttt actacttaat tgcattcttt gctaatttcc 4080 tttccttgct gtctgttctt ttctaacagc tgaagaatgt tctgctgact ctgacctcaa 4140 ctttcttatt cctgttgcag tgggtgtggc cttgggcttc cttataattg ttgtctttat 4200 ctcttatatg attggaagaa ggaaaagtcg tactggttat cagtctgtgt aatcagttaa 4260 atctagtgtt tgtttgtttt tttcaattag aagttacgtt tccattggct aaaagccagg 4320 acatgctgtg caatagattg tttaagatat gcagactaac ttcagtgagt tcctagctaa 4380 cttgggcatg agtacactta tttaagacaa aatatattag gaccaatttt tttctgtttt 4440 ttttcttcct ttgttaaagt ataattaaaa gaaaaattgt ggcttagaat tttttaagta 4500 aataatgatt ttaagcccct ggatccaatt atgaaagcat ttttgctgat gtgtaatttt 4560 atatgttaca gttacttata ttttactact ttgatgttat ttgcaaaatc aaaggtgtta 4620 aagaatttaa cttgcttcag gaaataaatt caagaacata gtggattcat tttcattggt 4680 ggcagacacg aaatttggtt catgataaga cttcctttcc ccacctcctg atcagcatta 4740 tttaaatctg tatttttctg ttagttaaga aagaaatggc ttcatgatat tgtatttaat 4800 agcaaaagtt tggctgtctt cttcattact gttaatagct actatatttt aacaaggaga 4860 tttctttttt tgttgttgtt gttctagagt ttggaatata ctgattatct cagacttgac 4920 atttatactg aaggatgaag taagacctcc agcttttttt aaaaaaggtg ttgatttgga 4980 acacctgtat gggttatggt ttattaaggt tatggtttag aaagtttttt tccctcagag 5040 ccttaacttg ttaagaaggt tcatttatcc tgcactgaaa acaaaaactc tatatacttt 5100 gtttgtgtgc ctcctgcact ctcccattcc ctatgtgaat atgctctagt tgatattttt 5160 aatatattga tttctttttt ctcacagcaa caagtgctta ctctagaggt tagtgggccc 5220 tgatatgtca tcagtcagat gcctgcctag ccaaagctgg actaagatta ttctgtacat 5280 ttgttgatct tgatatagac ttatatccct gtagggactg ctaatggctc cggcttctgg 5340 agtaaggtac tggagaccac tcatccctgt gtctgcttga ttggttcagc tgttgaattg 5400 cccttttatt tggaagcagt gttgaagttg tctagggttc aaatggctgc tttgtacacc 5460 tgtcattagt ataaggcaga tgtttatttt atcaagctat tttatctcta catttaacta 5520 aaaacaaaag ttcccaaaga tctgccttca cttcagaaat tttttttgga ttaaaaaaat 5580 taagcctgaa ccttaaataa agtgagttgg ttattcattc caaggattaa gtcccaatct 5640 acctctcagc acaatgcaga agctcaccac tgtattgctg ccattaactc atgccagaac 5700 cctttgccaa taactggaat tacaaatttt tgttaaagaa aatttatcaa gatctttctt 5760 tactgccttc tctatatgta catctcaaaa acatgtacat ctcaaaaact ggagtagaaa 5820 gttagattgc tcaactacaa ctcctctaga actctatagc tctgacatac agattcacac 5880 tctcctctat ttgctaagta tgtaaagaat gttttctttt aaaatgttct cttttgagaa 5940 caactgctta tttgttataa aagcatttgg ttaaaatgat gtcatcataa aaaacagtgg 6000 ctttgtttca atacatattt ttgagatgat tatctagaag ccagattaat aaaatcagct 6060 tgtgaccttg ctaagcatat aaactggaaa ttcagataca ttcaaaatta tgggttcatt 6120 taaaagtgtt ctaccttttg ggtatgagac taatatcact aattcctcaa tagttatcat 6180 ggctctatct taattaatta gaaaatatgt gtgtttaatt ctttgagaat taaaatagag 6240 aatattaaca gagggttaaa aactgcttca actccaataa gataaaggaa gctcaaaatc 6300 tatgagctga gtgttcaatt agctttgcct actgagttca attttatgtc aatacaacag 6360 tggatcagac agtacgactt tgaactggtg aatgtaaaca attgtttttc acctaagctg 6420 ctttggaaga actgatgctt gctgctaact aaagttttgg atgtatcgat ttagagaacc 6480 aattaatacc tgcaaaataa agcatactgt ggtacttctg tttgatctag tatgtgtgat 6540 tttagattga tggattaaaa attaataaag atcatacatt ccataccaaa aaaaaaaaaa 6600 aaa 6603 <210> 12 <211> 1414 <212> DNA <213> Homo sapiens <400> 12 gccaggaccc tggaaggaag caggatggca gccggaacag cagttggagc ctgggtgctg 60 gtcctcagtc tgtggggggc agtagtaggt gctcaaaaca tcacagcccg gattggcgag 120 ccactggtgc tgaagtgtaa gggggccccc aagaaaccac cccagcggct ggaatggaaa 180 ctgaacacag gccggacaga agcttggaag gtcctgtctc cccagggagg aggcccctgg 240 gacagtgtgg ctcgtgtcct tcccaacggc tccctcttcc ttccggctgt cgggatccag 300 gatgagggga ttttccggtg ccaggcaatg aacaggaatg gaaaggagac caagtccaac 360 taccgagtcc gtgtctacca gattcctggg aagccagaaa ttgtagattc tgcctctgaa 420 ctcacggctg gtgttcccaa taaggtgggg acatgtgtgt cagagggaag ctaccctgca 480 gggactctta gctggcactt ggatgggaag cccctggtgc ctaatgagaa gggagtatct 540 gtgaaggaac agaccaggag acaccctgag acagggctct tcacactgca gtcggagcta 600 atggtgaccc cagcccgggg aggagatccc cgtcccacct tctcctgtag cttcagccca 660 ggccttcccc gacaccgggc cttgcgcaca gcccccatcc agccccgtgt ctgggagcct 720 gtgcctctgg aggaggtcca attggtggtg gagccagaag gtggagcagt agctcctggt 780 ggaaccgtaa ccctgacctg tgaagtccct gcccagccct ctcctcaaat ccactggatg 840 aaggatggtg tgcccttgcc ccttcccccc agccctgtgc tgatcctccc tgagataggg 900 cctcaggacc agggaaccta cagctgtgtg gccacccatt ccagccacgg gccccaggaa 960 agccgtgctg tcagcatcag catcatcgaa ccaggcgagg aggggccaac tgcaggctct 1020 gtgggaggat cagggctggg aactctagcc ctggccctgg ggatcctggg aggcctgggg 1080 acagccgccc tgctcattgg ggtcatcttg tggcaaaggc ggcaacgccg aggagaggag 1140 aggaaggccc cagaaaacca ggaggaagag gaggagcgtg cagaactgaa tcagtcggag 1200 gaacctgagg caggcgagag tagtactgga gggccttgag gggcccacag acagatccca 1260 tccatcagct cccttttctt tttcccttga actgttctgg cctcagacca actctctcct 1320 gtataatctc tctcctgtat aaccccacct tgccaagctt tcttctacaa ccagagcccc 1380 ccacaatgat gattaaacac ctgacacatc ttga 1414 <210> 13 <211> 1987 <212> DNA <213> Homo sapiens <400> 13 agccgccgcc gtctccgccg tcgctggggc agctgccgcg gtggtcgcct ctggcagtgc 60 cgctagcttt caggcagtcg cctctcctcc cgacatcccg ccttgaggag gctgaggcgg 120 aatcgcggct ggcggcgggg ggacggaccg gccctgcagt ggccgcagtg acagcccgga 180 cccggccctc cgcccgctct cgcctcggcg cccgcagcca cgatgaaccg gggcggcggc 240 agcccgtcgg ccgccgccaa ctacctgctc tgtaccaact gccggaaagt gctgcggaag 300 gataaaagaa tcagagtgtc tcaacccttg acaagaggac caagtgcctt tattccagag 360 aaggaagttg tccaagcaaa cacagtggat gaacgtacta actttcttgt ggaagaatac 420 tctacatccg gtcgtctgga caacatcaca caggtcatga gtttacacac tcagtacctg 480 gagtctttct tgcggagcca gttttacatg ttgcgcatgg atggtcccct tcctctacca 540 tacaggcact atattgcaat aatggctgca gctagacatc agtgttctta cttaataaac 600 atgcatgtgg atgaattttt aaagactgga ggtattgctg agtggttgaa tggtttggaa 660 tatgtgccac aaagactgaa aaatcttaat gaaattaata agctgctagc acatcgacct 720 tggctgatca caaaagagca cattcagaaa cttgtcaaaa ctggagaaaa taattggtct 780 ctgcctgaac tggtacatgc tgtggtcctc ctggcacatt atcatgcttt ggcaagcttt 840 gtttttggta gtggtatcaa tccagagaga gatccagaaa tctccaatgg attcaggcta 900 atatcagtca acaatttctg cgtttgtgat cttgctaatg acaacaacat agagaatgca 960 tctctttcag gcagcaactt tgggattgtg gattctctaa gtgagctaga ggccttaatg 1020 gaaaggatga aaagacttca agaagaaagg gaagatgaag aggcgtctca agaagaaatg 1080 agcactcgtt ttgaaaagga gaagaaagaa agtctttttg tggtctctgg agatactttt 1140 cattcatttc ctcattcaga ttttgaggat gacatgatta taacatctga tgtctctcga 1200 tatattgaag accctggttt tgggtatgaa gactttgcca gacgaggaga agagcatttg 1260 ccaacattcc gagctcagga ctatacctgg gaaaatcatg ggttctccct ggtgaacaga 1320 ctttattctg acattggaca tcttcttgat gaaaagtttc ggatggtcta caatctcaca 1380 tataacacta tggccaccca tgaggatgtt gacacaacca tgctgcgcag agctttattt 1440 aactatgttc actgtatgtt tggaatcagg tatgatgact atgattatgg agaagttaat 1500 caattacttg aaagaagcct gaaggtttac attaagacag tgacctgcta tcctgagaga 1560 actacaaaac gcatgtatga tagttactgg cggcagttca aacactcaga aaaagttcat 1620 gtcaatctac ttttaatgga agcacgaatg caagctgaac ttctttatgc tcttcgtgcc 1680 ataactcggc atttgacctg aagtatcacc caaggaaaat gtcatacatg tgtaaagacc 1740 tttcacataa gataaacatt gaagctattt gtgatatagc atcaaaaatt attcagttct 1800 ctagtgtcaa agtttagccg tttgtttttt tttttttgtt ttttgcggct gtaatgtgca 1860 atgatgtgtt ttattttcct tgatgcttaa cattactaac aattgcaaaa ataatactga 1920 ggagcactac tttgcattgt ttgtagttgg agttttggat actgatcata aatcatgaat 1980 ctggcgt 1987 <210> 14 <211> 1402 <212> DNA <213> Homo sapiens <400> 14 ggggacgaag ggaagctcca gcgtgtggcc ccggcgagtg cggataaaag ccgccccgcc 60 gggctcgggc ttcattctga gccgagcccg gtgccaagcg cagctagctc agcaggcggc 120 agcggcggcc tgagcttcag ggcagccagc tccctcccgg tctcgccttc cctcgcggtc 180 agcatgaaag ccttcagtcc cgtgaggtcc gttaggaaaa acagcctgtc ggaccacagc 240 ctgggcatct cccggagcaa aacccctgtg gacgacccga tgagcctgct atacaacatg 300 aacgactgct actccaagct caaggagctg gtgcccagca tcccccagaa caagaaggtg 360 agcaagatgg aaatcctgca gcacgtcatc gactacatct tggacctgca gatcgccctg 420 gactcgcatc ccactattgt cagcctgcat caccagagac ccgggcagaa ccaggcgtcc 480 aggacgccgc tgaccaccct caacacggat atcagcatcc tgtccttgca ggcttctgaa 540 ttcccttctg agttaatgtc aaatgacagc aaagcactgt gtggctgaat aagcggtgtt 600 catgatttct tttattcttt gcacaacaac aacaacaaca aattcacgga atcttttaag 660 tgctgaactt atttttcaac catttcacaa ggaggacaag ttgaatggac ctttttaaaa 720 agaaaaaaaa aatggaagga aaactaagaa tgatcatctt cccagggtgt tctcttactt 780 ggactgtgat attcgttatt tatgaaaaag acttttaaat gccctttctg cagttggaag 840 gttttcttta tatactattc ccaccatggg gagcgaaaac gttaaaatca caaggaattg 900 cccaatctaa gcagactttg ccttttttca aaggtggagc gtgaatacca gaaggatcca 960 gtattcagtc acttaaatga agtcttttgg tcagaaatta cctttttgac acaagcctac 1020 tgaatgctgt gtatatattt atatataaat atatctattt gagtgaaacc ttgtgaactc 1080 tttaattaga gttttcttgt atagtggcag agatgtctat ttctgcattc aaaagtgtaa 1140 tgatgtactt attcatgcta aactttttat aaaagtttag ttgtaaactt aaccctttta 1200 tacaaaataa atcaagtgtg tttattgaat ggtgattgcc tgctttattt cagaggacca 1260 gtgctttgat ttttattatg ctatgttata actgaaccca aataaataca agttcaaatt 1320 tatgtagact gtataagatt ataataaaac atgtctgaag tcaaaaaaaa aaaaaaaaaa 1380 aaaaaaaaaa aaaaaaaaaa aa 1402 <210> 15 <211> 4462 <212> DNA <213> Homo sapiens <400> 15 gcgccgcgtg cccggccgcg cccagcaggg tttccaggcc tgaggtgccc gccctggccc 60 caggagaatg aaccagccgc agaggatggc gcctgtgggc acagacaagg agctcagtga 120 cctcctggac ttcagcatga tgttcccgct gcctgtcacc aacgggaagg gccggcccgc 180 ctccctggcc ggggcgcagt tcggaggttc aggtcttgag gaccggccca gctcaggctc 240 ctggggcagc ggcgaccaga gcagctcctc ctttgacccc agccggacct tcagcgaggg 300 cacccacttc actgagtcgc acagcagcct ctcttcatcc acattcctgg gaccgggact 360 cggaggcaag agcggtgagc ggggcgccta tgcctccttc gggagagacg caggcgtggg 420 cggcctgact caggctggct tcctgtcagg cgagctggcc ctcaacagcc ccgggcccct 480 gtccccttcg ggcatgaagg ggacctccca gtactacccc tcctactccg gcagctcccg 540 gcggagagcg gcagacggca gcctagacac gcagcccaag aaggtccgga aggtcccgcc 600 gggtcttcca tcctcggtgt acccacccag ctcaggtgag gactacggca gggatgccac 660 cgcctacccg tccgccaaga cccccagcag cacctatccc gcccccttct acgtggcaga 720 tggcagcctg cacccctcag ccgagctctg gagtcccccg ggccaggcgg gcttcgggcc 780 catgctgggt gggggctcat ccccgctgcc cctcccgccc ggtagcggcc cggtgggcag 840 cagtggaagc agcagcacgt ttggtggcct gcaccagcac gagcgtatgg gctaccagct 900 gcatggagca gaggtgaacg gtgggctccc atctgcatcc tccttctcct cagcccccgg 960 agccacgtac ggcggcgtct ccagccacac gccgcctgtc agcggggccg acagcctcct 1020 gggctcccga gggaccacag ctggcagctc cggggatgcc ctcggcaaag cactggcctc 1080 gatctactcc ccggatcact caagcaataa cttctcgtcc agcccttcta cccccgtggg 1140 ctccccccag ggcctggcag gaacgtcaca gtggcctcga gcaggagccc ccggtgcctt 1200 atcgcccagc tacgacgggg gtctccacgg cctgcagagt aagatagaag accacctgga 1260 cgaggccatc cacgtgctcc gcagccacgc cgtgggcaca gccggcgaca tgcacacgct 1320 gctgcctggc cacggggcgc tggcctcagg tttcaccggc cccatgtcac tgggcgggcg 1380 gcacgcaggc ctggttggag gcagccaccc cgaggacggc ctcgcaggca gcaccagcct 1440 catgcacaac cacgcggccc tccccagcca gccaggcacc ctccctgacc tgtctcggcc 1500 tcccgactcc tacagtgggc tagggcgagc aggtgccacg gcggccgcca gcgagatcaa 1560 gcgggaggag aaggaggacg aggagaacac gtcagcggct gaccactcgg aggaggagaa 1620 gaaggagctg aaggcccccc gggcccggac cagcccagac gaggacgagg acgaccttct 1680 ccccccagag cagaaggccg agcgggagaa ggagcgccgg gtggccaata acgcccggga 1740 gcggctgcgg gtccgtgaca tcaacgaggc ctttaaggag ctggggcgca tgtgccaact 1800 gcacctcaac agcgagaagc cccagaccaa actgctcatc ctgcaccagg ctgtctcggt 1860 catcctgaac ttggagcagc aagtgcgaga gcggaacctg aatcccaaag cagcctgttt 1920 gaaacggcga gaagaggaaa aggtgtcagg tgtggttgga gacccccaga tggtgctttc 1980 agctccccac ccaggcctga gcgaagccca caaccccgcc gggcacatgt gaaaggtatg 2040 cctccgtggg acgagccacc cgctttcagc cctgtgctct ggccccagaa cggccactcg 2100 agaccccggg cttcatccac atccacacct cacacacctg ttgtcagcat cgagccaaca 2160 ccaacctgac aaggttcgga gtgatggggg cggccaaggt gacactgggt ccaggagctc 2220 cctggggccc tggcctacca ctcactggcc tcgctccccc tgtccccgaa tctcagccac 2280 cgtgtcactc tgtgacctgt cccatggatc ctgaaactgc atcttggccc tgttgcctgg 2340 gctgacagga gcattttttt tttttccagt aaacaaaacc tgaaagcaag caacaaaaca 2400 tacactttgt cagagaagaa aaaaatgcct taactataaa aagcggagaa atggaaacat 2460 atcactcaag ggggatgctg tggaaacctg gcttattctt ctaaagccac cagcaaattg 2520 tgcctaagcg aaatattttt tttaaggaaa ataaaaacat tagttacaag attttttttt 2580 tcttaatgta gatgaaaatt agcaaggatg ctgcctttgg tctctggttt ttttaagctt 2640 tttttgcata tgttttgtaa gcaacaaatt tttttgtata aaagtcccgt gtctctcgct 2700 atttctgctg ctgttcctag actgagcatt gcatttcttg atcaaccaga tgattaaacg 2760 ttgtattaaa aagaccccgt gtaaacctga gcccccccgt cccccccccc ccccggaagc 2820 cactgcacac agacagaacg gggacaggcg gcgggtcttt tgtttttttg atgttggggg 2880 ttctcttggt tttgtcatgt ggaaagtgat gcgtgggcgt tccctgatga aggcaccttg 2940 gggcttccct gccgcatcct ctcccctcag gaaggggact gacctgggct tgggggaagg 3000 gacgtcagca aggtggctct gaccctccca ggtgactctg ccaagcagct gtggccccca 3060 gggctaccct acacaacgcc ctccccaggc ccccctaagc tgctctccct tggaacctgc 3120 acagctctct gaaatggggc attttgttgg gaccagtgac ccctggcatg gggaccacac 3180 cctggagccc ggtgctgggg acctcctgga caccctgtcc ttcactcctt tgccccaggg 3240 acccaggctc atgctctgaa ctctggctga gaggatgctg ctcaggagcc agcacaggac 3300 accccccacc ccaccccacc atgtccccat tacaccagag ggccatcgtg acgtagacag 3360 gatgccaggg gcctggccag cctcccccaa tgctggggag catccctggg cctggggcca 3420 cacctgctgc cctccctctg tgtggtccaa gggcaagagt ggctggagcc gggggactgt 3480 gctggtctga gccccacgaa ggccttgggc tgtgcgtccg accctgctgc agaaccagca 3540 gggtgtcccc tcgggcccat ctgtgtccca tgtcccagca cccaggcctc tctccaggtc 3600 tccttttctg gtcttttgcc atgagggtaa ccagctcttc ccagctggct ggggactgtc 3660 ttgggtttaa aactgcaagt ctcctaccct gggatcccat ccagttccac acgaactagg 3720 gcagtggtca ctgtggcacc caggtgtggg cctggctagc tgggggcctt catgtgccct 3780 tcatgcccct ccctgcattg aggccttgtg gacccctggg ctggctgtgt tcatccccgc 3840 tgcaggtcgg gcgtctcccc ccgtgccact cctgagactc ccaccgttac ccccaggaga 3900 tcctggactg cctgactccc ctccccagac tggcttggga gcctgggccc catggtagat 3960 gcaagggaaa cctcaaggcc agctcaatgc ctggtatctg cccccagtcc aggccaggcg 4020 gaggggaggg gctgtccggc tgcctctccc ttctcggtgg cttcccctac gccctgggag 4080 tttgatctct taagggaact tgcctctccc tcttgttttg ctcctggccc tgcccctagg 4140 tctgggtggg cagtggcccc atagcctctg gaactgtgcg ttctgcatag aattcaaacg 4200 agattcaccc agcgcgagga ggaagaaaca gcagttcctg ggaaccacaa ttatgggggg 4260 tggggggtgt gatctgagtg cctcaagatg gttttcaaaa aaattttttt aaagaaaata 4320 attgtatacg tgtcaacaca gctggctgga tgattgggac tttaaaacga ccctctttca 4380 ggtggattca gagacctgtc ctgtatataa cagcactgta gcaataaacg tgacatttta 4440 taacgaaaaa aaaaaaaaaa aa 4462 <210> 16 <211> 1527 <212> DNA <213> Homo sapiens <400> 16 ggggatgtgg cccgtggcct agctcgtcaa gttgccgtgg cgcggagaac tctgcaaaac 60 aagaggctga ggattgcgtt agagataaac cagttcacgc cggagccccg tgagggaagc 120 gtctccgttg ggtccggccg ctctgcggga ctctgaggaa aagctcgcac caggtggacg 180 cggatctgtc aacatgggta aaggagaccc caacaagccg cggggcaaaa tgtcctcgta 240 cgccttcttc gtgcagacct gccgggaaga gcacaagaag aaacacccgg actcttccgt 300 caatttcgcg gaattctcca agaagtgttc ggagagatgg aagaccatgt ctgcaaagga 360 gaagtcgaag tttgaagata tggcaaaaag tgacaaagct cgctatgaca gggagatgaa 420 aaattacgtt cctcccaaag gtgataagaa ggggaagaaa aaggacccca atgctcctaa 480 aaggccacca tctgccttct tcctgttttg ctctgaacat cgcccaaaga tcaaaagtga 540 acaccctggc ctatccattg gggatactgc aaagaaattg ggtgaaatgt ggtctgagca 600 gtcagccaaa gataaacaac catatgaaca gaaagcagct aagctaaagg agaaatatga 660 aaaggatatt gctgcatatc gtgccaaggg caaaagtgaa gcaggaaaga agggccctgg 720 caggccaaca ggctcaaaga agaagaacga accagaagat gaggaggagg aggaggaaga 780 agaagatgaa gatgaggagg aagaggatga agatgaagaa taaatggcta tcctttaatg 840 atgcgtgtgg aatgtgtgtg tgtgctcagg caattatttt gctaagaatg tgaattcaag 900 tgcagctcaa tactagcttc agtataaaaa ctgtacagat ttttgtatag ctgataagat 960 tctctgtaga gaaaatactt ttaaaaaatg caggttgtag ctttttgatg ggctactcat 1020 acagttagat tttacagctt ctgatgttga atgttcctaa atatttaatg gtttttttaa 1080 tttcttgtgt atggtagcac agcaaacttg taggaattag tatcaatagt aaattttggg 1140 ttttttagga tgttgcattt cgttttttta aaaaaaattt tgtaataaaa ttatgtatat 1200 tatttctatt gtctttgtct taatatgcta agttaatttt cactttaaaa aagccatttg 1260 aagaccagag ctatgttgat ttttttcggt atttctgcct agtagttctt agacacagtt 1320 gacctagtaa aatgtttgag aattaaaacc aaacatgctc atatttgcaa aatgttcttt 1380 aaaagttaca tgttgaactc agtgaacttt ataagaattt atgcagtttt acagaacgtt 1440 aagttttgta cttgacgttt ctgtttatta gctaaattgt tcctcaggtg tgtgtatata 1500 tatatacata tatatatata tatatat 1527 <210> 17 <211> 4927 <212> DNA <213> Homo sapiens <400> 17 cccggcttta tatctatata tacacaggta tatgtgtata ttttatataa ttgttctccg 60 ttcgttgata tcaaagacag ttgaaggaaa tgaattttga aacttcacgg tgtgccaccc 120 tacagtactg ccctgaccct tacatccagc gtttcgtaga aaccccagct catttctctt 180 ggaaagaaag ttattaccga tccaccatgt cccagagcac acagacaaat gaattcctca 240 gtccagaggt tttccagcat atctgggatt ttctggaaca gcctatatgt tcagttcagc 300 ccattgactt gaactttgtg gatgaaccat cagaagatgg tgcgacaaac aagattgaga 360 ttagcatgga ctgtatccgc atgcaggact cggacctgag tgaccccatg tggccacagt 420 acacgaacct ggggctcctg aacagcatgg accagcagat tcagaacggc tcctcgtcca 480 ccagtcccta taacacagac cacgcgcaga acagcgtcac ggcgccctcg ccctacgcac 540 agcccagctc caccttcgat gctctctctc catcacccgc catcccctcc aacaccgact 600 acccaggccc gcacagtttc gacgtgtcct tccagcagtc gagcaccgcc aagtcggcca 660 cctggacgta ttccactgaa ctgaagaaac tctactgcca aattgcaaag acatgcccca 720 tccagatcaa ggtgatgacc ccacctcctc agggagctgt tatccgcgcc atgcctgtct 780 acaaaaaagc tgagcacgtc acggaggtgg tgaagcggtg ccccaaccat gagctgagcc 840 gtgaattcaa cgagggacag attgcccctc ctagtcattt gattcgagta gaggggaaca 900 gccatgccca gtatgtagaa gatcccatca caggaagaca gagtgtgctg gtaccttatg 960 agccacccca ggttggcact gaattcacga cagtcttgta caatttcatg tgtaacagca 1020 gttgtgttgg agggatgaac cgccgtccaa ttttaatcat tgttactctg gaaaccagag 1080 atgggcaagt cctgggccga cgctgctttg aggcccggat ctgtgcttgc ccaggaagag 1140 acaggaaggc ggatgaagat agcatcagaa agcagcaagt ttcggacagt acaaagaacg 1200 gtgatggtac gaagcgcccg tttcgtcaga acacacatgg tatccagatg acatccatca 1260 agaaacgaag atccccagat gatgaactgt tatacttacc agtgaggggc cgtgagactt 1320 atgaaatgct gttgaagatc aaagagtccc tggaactcat gcagtacctt cctcagcaca 1380 caattgaaac gtacaggcaa cagcaacagc agcagcacca gcacttactt cagaaacaga 1440 cctcaataca gtctccatct tcatatggta acagctcccc acctctgaac aaaatgaaca 1500 gcatgaacaa gctgccttct gtgagccagc ttatcaaccc tcagcagcgc aacgccctca 1560 ctcctacaac cattcctgat ggcatgggag ccaacattcc catgatgggc acccacatgc 1620 caatggctgg agacatgaat ggactcagcc ccacccaggc actccctccc ccactctcca 1680 tgccatccac ctcccactgc acacccccac ctccgtatcc cacagattgc agcattgtca 1740 gtttcttagc gaggttgggc tgttcatcat gtctggacta tttcacgacc caggggctga 1800 ccaccatcta tcagattgag cattactcca tggatgatct ggcaagtctg aaaatccctg 1860 agcaatttcg acatgcgatc tggaagggca tcctggacca ccggcagctc cacgaattct 1920 cctccccttc tcatctcctg cggaccccaa gcagtgcctc tacagtcagt gtgggctcca 1980 gtgagacccg gggtgagcgt gttattgatg ctgtgcgatt caccctccgc cagaccatct 2040 ctttcccacc ccgagatgag tggaatgact tcaactttga catggatgct cgccgcaata 2100 agcaacagcg catcaaagag gagggggagt gagcctcacc atgtgagctc ttcctatccc 2160 tctcctaact gccagccccc taaaagcact cctgcttaat cttcaaagcc ttctccctag 2220 ctcctcccct tcctcttgtc tgatttctta ggggaaggag aagtaagagg ctacctctta 2280 cctaacatct gacctggcat ctaattctga ttctggcttt aagccttcaa aactatagct 2340 tgcagaactg tagctgccat ggctaggtag aagtgagcaa aaaagagttg ggtgtctcct 2400 taagctgcag agatttctca ttgactttta taaagcatgt tcacccttat agtctaagac 2460 tatatatata aatgtataaa tatacagtat agatttttgg gtggggggca ttgagtattg 2520 tttaaaatgt aatttaaatg aaagaaaatt gagttgcact tattgaccat tttttaattt 2580 acttgttttg gatggcttgt ctatactcct tcccttaagg ggtatcatgt atggtgatag 2640 gtatctagag cttaatgcta catgtgagtg acgatgatgt acagattctt tcagttcttt 2700 ggattctaaa tacatgccac atcaaacctt tgagtagatc catttccatt gcttattatg 2760 taggtaagac tgtagatatg tattcttttc tcagtgttgg tatattttat attactgaca 2820 tttcttctag tgatgatggt tcacgttggg gtgatttaat ccagttataa gaagaagttc 2880 atgtccaaac gtcctcttta gtttttggtt gggaatgagg aaaattctta aaaggcccat 2940 agcagccagt tcaaaaacac ccgacgtcat gtatttgagc atatcagtaa cccccttaaa 3000 tttaatacca gataccttat cttacaatat tgattgggaa aacatttgct gccattacag 3060 aggtattaaa actaaatttc actactagat tgactaactc aaatacacat ttgctactgt 3120 tgtaagaatt ctgattgatt tgattgggat gaatgccatc tatctagttc taacagtgaa 3180 gttttactgt ctattaatat tcagggtaaa taggaatcat tcagaaatgt tgagtctgta 3240 ctaaacagta agatatctca atgaaccata aattcaactt tgtaaaaatc ttttgaagca 3300 tagataatat tgtttggtaa atgtttcttt tgtttggtaa atgtttcttt taaagaccct 3360 cctattctat aaaactctgc atgtagaggc ttgtttacct ttctctctct aaggtttaca 3420 ataggagtgg tgatttgaaa aatataaaat tatgagattg gttttcctgt ggcataaatt 3480 gcatcactgt atcattttct tttttaaccg gtaagagttt cagtttgttg gaaagtaact 3540 gtgagaaccc agtttcccgt ccatctccct tagggactac ccatagacat gaaaggtccc 3600 cacagagcaa gagataagtc tttcatggct gctgttgctt aaaccactta aacgaagagt 3660 tcccttgaaa ctttgggaaa acatgttaat gacaatattc cagatctttc agaaatataa 3720 cacatttttt tgcatgcatg caaatgagct ctgaaatctt cccatgcatt ctggtcaagg 3780 gctgtcattg cacataagct tccattttaa ttttaaagtg caaaagggcc agcgtggctc 3840 taaaaggtaa tgtgtggatt gcctctgaaa agtgtgtata tattttgtgt gaaattgcat 3900 actttgtatt ttgattattt tttttttctt cttgggatag tgggatttcc agaaccacac 3960 ttgaaacctt tttttatcgt ttttgtattt tcatgaaaat accatttagt aagaatacca 4020 catcaaataa gaaataatgc tacaatttta agaggggagg gaagggaaag ttttttttta 4080 ttattttttt aaaattttgt atgttaaaga gaatgagtcc ttgatttcaa agttttgttg 4140 tacttaaatg gtaataagca ctgtaaactt ctgcaacaag catgcagctt tgcaaaccca 4200 ttaaggggaa gaatgaaagc tgttccttgg tcctagtaag aagacaaact gcttccctta 4260 ctttgctgag ggtttgaata aacctaggac ttccgagcta tgtcagtact attcaggtaa 4320 cactagggcc ttggaaattc ctgtactgtg tctcatggat ttggcactag ccaaagcgag 4380 gcacccttac tggcttacct cctcatggca gcctactctc cttgagtgta tgagtagcca 4440 gggtaagggg taaaaggata gtaagcatag aaaccactag aaagtgggct taatggagtt 4500 cttgtggcct cagctcaatg cagttagctg aagaattgaa aagtttttgt ttggagacgt 4560 ttataaacag aaatggaaag cagagttttc attaaatcct tttacctttt ttttttcttg 4620 gtaatcccct aaaataacag tatgtgggat attgaatgtt aaagggatat ttttttctat 4680 tatttttata attgtacaaa attaagcaaa tgttaaaagt tttatatgct ttattaatgt 4740 tttcaaaagg tattatacat gtgatacatt ttttaagctt cagttgcttg tcttctggta 4800 ctttctgtta tgggcttttg gggagccaga agccaatcta caatctcttt ttgtttgcca 4860 ggacatgcaa taaaatttaa aaaataaata aaaactaatt aagaaattga aaaaaaaaaa 4920 aaaaaaa 4927 <210> 18 <211> 1954 <212> DNA <213> Homo sapiens <400> 18 cgcatgcgca ggcgacagct catggcgttc agggcctgac ggttgctagg gtgacaggga 60 cacaacatgg cggcgggatc tctaacgctc tccttcgagg gaccaccacg gagatcctag 120 tgcgggaccc cgcctcaggg aagtggaaag cagggggaca accttcctgc ttccttcttt 180 tccgtccagt gtcggcaagg ggttgtcacc ggcttccgca tccaagatga agaactataa 240 agcaattggc aaaataggag agggaacgtt ttctgaagtt atgaagatgc aaagcctgag 300 agatggaaac tactatgcat gtaaacaaat gaagcagcgc tttgaaagta ttgagcaagt 360 caacaaccta cgagagatcc aagcactgag gcgcctgaat ccgcacccaa acattcttat 420 gttgcatgaa gtggtttttg acagaaaatc tggttctctt gcactaatat gtgaacttat 480 ggacatgaat atttatgagc taatacgagg gagaagatac ccattatcag aaaaaaaaat 540 tatgcactat atgtaccagt tatgtaagtc cctggatcat attcacagaa atggaatatt 600 tcacagagat gtaaaaccag aaaatatact aataaagcag gatgtcctga aattagggga 660 ctttggctcc tgccggagtg tctattccaa gcagccgtac acggaataca tctccacccg 720 ctggtaccgg gccccggagt gtctcctcac tgatgggttc tacacgtaca agatggacct 780 gtggagcgcc ggctgtgtgt tctacgagat cgccagtctg cagcccctct ttcctggagt 840 aaatgaactg gaccaaatct caaaaatcca cgatgtcatc ggcacacccg ctcagaagat 900 cctcaccaag ttcaaacagt cgagagctat gaattttgat tttcctttta aaaagggatc 960 aggaatacct ctactaacaa ccaatttgtc cccacaatgc ctctccctcc tgcacgcaat 1020 ggtggcctat gatcccgatg agagaatcgc cgcccaccag gccctgcagc acccctactt 1080 ccaagaacag aggaaaacag agaagcgggc tctgggcagc cacagaaaag ctggctttcc 1140 ggagcaccct gtggcaccgg aaccactcag taacagctgc cagatttcca aggagggcag 1200 aaagcagaaa cagtccctaa agcaagagga ggaccgtccc aagagacgag gaccggccta 1260 tgtcatggaa ctgcccaaac taaagctttc gggagtggtc agactgtcgt cttactccag 1320 ccccacgctg cagtccgtgc ttggatctgg aacaaatgga agagtgccgg tgctgagacc 1380 cttgaagtgc atccctgcga gcaagaagac agatccgcag aaggacctta agcctgcccc 1440 gcagcagtgt cgcctgccca ccatagtgcg gaaaggcgga agataactga gcagcaccgt 1500 cgtctcgact tcggaggcaa caccaagccc gaccgggcca ggcctgggtg atctgctgct 1560 gagacgccac ggagggctgg ggatgcgcct gcgtccgttt cgcgctggcc ggggctctgg 1620 gtgctgccct gcgccctgcc gcacccgcgg cccgcgcagc tgcctaggat gttctgggct 1680 aatatacttg taaaaccacc gcattctagg gttttctttc attttcgtta agaatttggg 1740 gcaggaaata ctttgtaact ttgtatatga atcaaaacaa acgagcaggc atttctgtga 1800 tgtgttgggc gtggttggaa ggtgggttct gcgtgtccct tcccagcgct gctggtcagt 1860 cgtggagcgc catcatgtct taccagtgac gctgctgaca cccctgactt ttattaaaga 1920 ataagctgtc gttaaaaaaa aaaaaaaaaa aaaa 1954 <210> 19 <211> 4031 <212> DNA <213> Homo sapiens <400> 19 cctcagtcct cccttggtgg cctcgccgcg gctctgctgg gagacccggc gctggcggct 60 gctgaggccg gagcggaggg cccgggagcg tgggagcagg agggtggcgc gcagccggtt 120 tcgcgtttgg tcggccaggg agctgccttc ccaccagccg gtcgaggaaa caacgggtcg 180 ggcttccggg gagagggccc acacagtctc ctcgccggca ccggcctcct ccatttttcc 240 gggccttgcg tggagggttt tggcggatgt ttttgaacga aggaatgtca tcggggctct 300 ctcgagcccc tcaccccgcc agctactctg ggggtggcgt ggcatagtga gaggagcgct 360 aagttgttgg gaggcctggg tccttttccc cacgactctg aaagaggaca gcgttcccaa 420 tgtcccagtt taagcgccag cggatcaacc cgcttccagg gggacgcaac ttctcaggca 480 cagcttcaac atctcttctg ggccctcctc ctggtttgct cactcctcct gtggccacag 540 aactgtccca gaatgccagg caccttcagg gtggggagaa acagcgggtc ttcactggta 600 ttgttaccag cttgcatgac tactttgggg ttgtggatga agaggtcttt tttcagctaa 660 gtgtggtgaa gggccgtctg ccccagctgg gtgagaaggt gctggtgaag gctgcataca 720 acccaggcca ggcagtgccc tggaatgctg tcaaggtgca aacgctctcc aaccagcccc 780 tactgaagtc cccagcacct cctcttctgc atgtagcagc cctgggccag aagcaaggga 840 tcctgggagc tcagcctcag ttgatcttcc agcctcaccg gattccccca ctctttcctc 900 agaagcctct gagtctcttc caaacatccc acacacttca cctgagccac ctgaacagat 960 ttcctgcccg gggccctcat ggacggttgg atcagggccg aagtgatgac tatgactcca 1020 agaaacgcaa acagcgggct ggtggagagc cctggggtgc taagaagcca aggcatgacc 1080 tgcctcctta ccgggtccac ctcactcctt acactgtgga cagccccatc tgtgacttcc 1140 tagaactcca gcgccgttac cgcagcctcc tggtcccctc agattttctg tccgtgcatc 1200 tgagttggct atcagccttc cccctgagcc agcccttttc cctccatcat ccaagccgga 1260 tccaggtctc ttctgaaaag gaggcagctc cagacgctgg tgctgagccc atcactgcag 1320 acagtgaccc cgcttatagt tcgaaggtac tgctgctctc ttccccgggg ttggaggaat 1380 tgtatcgttg ttgcatgctc tttgtggatg acatggctga gccaagggag acgccagagc 1440 atcctctgaa gcagattaag tttttgctgg gcaggaaaga agaggaggca gtgctggttg 1500 ggggtgaatg gtctccttcc ctggatggcc tcgaccccca ggctgacccg caggtgctgg 1560 tgcgtaccgc catccgctgt gcgcaggccc agactggcat tgatttgagc ggctgtacca 1620 agtggtggcg ctttgccgag tttcagtacc tgcagccggg acccccccgg cggcttcaga 1680 cagtggtggt gtacctgccg gatgtctgga ccatcatgcc tactttggag gagtgggagg 1740 ccctgtgcca gcagaaagct gcagaggcag ctcccccaac ccaggaggca caaggggaaa 1800 cggagcctac tgaacaggca cctgatgcct tggagcaagc agcagacact tctagacgga 1860 acgcagaaac tccagaggcc accacacagc aggaaacgga cactgatctc ccagaggccc 1920 ctccaccccc cctagaacct gctgtcatcg cacgccctgg ctgtgtaaac ctgtccctcc 1980 atgggattgt ggaggatcgg aggccaaagg aaaggatctc ttttgaggtg atggtgctgg 2040 ccgagctgtt tctggagatg ctccagaggg attttggcta tagagtttat aagatgctac 2100 tgagccttcc tgaaaaggtc gtgtccccac ctgaacctga gaaggaggag gcggccaagg 2160 aagaagccac caaggaggaa gaagccatca aagaggaggt ggtcaaggag cccaaggatg 2220 aggcacagaa tgagggcccg gctacagagt cagaggcccc gctgaaggag gatgggcttt 2280 tgcccaaacc actctcttct gggggagagg aagaagaaaa accccggggc gaggcttctg 2340 aggacctgtg tgagatggcc ctggacccag aactgttgct tctgagggat gatggagagg 2400 aggagtttgc aggagcaaag ctggaggatt cggaggtccg gtccgttgcc tcaaaccagt 2460 cagagatgga gttctcttca cttcaggaca tgcccaagga gctggatccc tctgctgtgc 2520 tccccttaga ctgtctgctt gcttttgtgt tctttgatgc caactggtgt ggctacttgc 2580 accggcgaga cttagagagg atcctcctta cccttgggat ccggctcagt gcagagcagg 2640 ccaagcagct ggtcagcagg gtggtgaccc agaacatctg ccagtaccgg agccttcagt 2700 acagccgcca ggagggcctg gatggtggcc ttcccgagga ggtgctcttc ggaaacctgg 2760 acctgctgcc ccctcctggg aaaagcacga agccaggtgc tgcccccaca gaacacaaag 2820 ccttggtgtc ccacaatggc agcctgatta acgtggggag cctgctgcag cgcgcggagc 2880 agcaggacag cggccggctc tacctagaga acaagatcca cacactggag ctgaagctgg 2940 aggagagcca taaccgtttc tcagccactg aagtaaccaa taagacgctg gcggcagaga 3000 tgcaggagct gcgagtccgg ctggcggagg ccgaggagac cgcccggacg gcggagcgac 3060 agaagagcca gctccagcgg ctgctgcagg agctccgcag gcgtctgacc cccctgcagc 3120 tggagatcca gcgggtggtg gaaaaggctg acagctgggt ggagaaggag gagccggcac 3180 ctagcaactg acggcctcgc acggaactgc catcctgtga gggcagcggt ggcgcccggc 3240 aaagttggag cccttgcggt accagaaagc agcgagagcg agacctggga gccagggcag 3300 gggtggctga ccccatgctc agcctctagg ggacggcagg ccatcaggct gggggctgtg 3360 ctatgtggga tggatgtgtg aggaaccccg gttccactta acaactaaat acaacatctt 3420 ttgcacccct agaatgtcat tttgccctca accttggtat ttctcctggg gcccttttag 3480 tcttgtgctg actttctcct gtcctcttcc agtttagaat aagacagggg agaaaaaggc 3540 ttttcgagtg tgggacaagg tctgatgtca gtgaacggaa ctgaagagca agacatggag 3600 cctggctggg gctaagcagc cccctcctcc ggatggcaca ggctctgcta ggttccggac 3660 acaggcttct gggggaaggg tctcccttgg ccatcacggg aatggagtcc atgctagaaa 3720 gagctcagtg ttgggctggg tttgccagta gaacactgcg ttccagtcac cccggtcttg 3780 ccagaagaaa ccagcacctc tttcccgtgg ctcctgtgtt cagaatgtgg tattggctct 3840 ggcccagcct tctcccctgt tacccataat tcttgcctct ttccataatc cgtggtttca 3900 gtttgacttt gtatataaag ttggggtttt tttttttttt ttttggcttg ttttttaaat 3960 aaaccaaagt caaaaacaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 4020 aaaaaaaaaa a 4031 <210> 20 <211> 5423 <212> DNA <213> Homo sapiens <400> 20 tttctcgctc gctcccgttc cccggacgcg gcggatgagc cggccccgct ggggaaggct 60 ccgggcggcg gcgggcggcc gggaggaggc tgcgtgctcg gggctggggc tgcgagcggg 120 gtgattttgt attaaaatga ggaggaggaa gaagaggcac ccacagcggc agcggcggcg 180 gcggcggcag cagcagcagg agcagcggcg gagagggctg cagcccgggc ggacgcgcgg 240 agccgagcgg ggcacggcgg cggcagcgac agcggccggg atgagtcaac taataattta 300 atgggggcag agacggcagc gaggggtaga gctagcgagg gagagagcga gagaagcagc 360 cccgtccggg gactcgcgct cacactcacg cacacacaca aacacacaca cacctctccc 420 tgtgccaccc agcaacaccc ggcctcgtca caacaacaac agccgcggcc gccctctatc 480 ctgcccgggg gcccagccga aagccagggc gactctagag gacgctgccc gcccccctct 540 ttcatttcgg gaaactcctg atcagttttg tcggggtttc tgggtttctt ttcccccaaa 600 gtcctagtgc cattgtggtg ctcgttgttt acctcggact ctggacgagt gagagcttgg 660 cgactttttg gggggagggg gcggggagtt tgtcgctgcc taggcggtgg aggtggctgg 720 gggtgccttc tgatcttcct cctcctcccc ctccccccga acctcttctc tcctcacttg 780 ctgggacccc agacgctcac agccccgcgt caatgggcag ggagagggtc cttgcggctg 840 ttgtcagcga gggcagaatc aaaagtggca ttttagtgcc tttccggggc ttttctcgcg 900 accccctgcc ccccaccctc gctgtccccc gctagatgcc ctcgttgggg gtgcgaggct 960 gtggggaaaa gtttaaggtt tgttaatatt agtcgcgatt gttggcgagg ggggtggggg 1020 tgattggaag ggaggcgagg tggccttccc aatgcgcgtt attcggggtt attgaagaat 1080 aatattgcaa gtgacagcca gaagtagact ttctgtcctc acaccgaaga acccgagtga 1140 gcaggaggga gggagagacg cgaagagacc ttttttcctt tttggagacc ttgtccgcag 1200 tgattttttt ttttttaaga gaatcctcag tcaccacgtc gtttccccag caccatcaca 1260 gtgtacagct cataacgggt tttgctttgt ttttacgatt tccccccaac gaatcacttg 1320 tcagatcaat tttatcttct tcctcctccc tgcttcccac tctcccctcc tccccatcgc 1380 aaaccctgtt ctctgaggtt agacatttta caaaccccta tatgttggtt ttcgaattgt 1440 gatttttttt ttaaacccct ttctcatggc tactcttcta gacgtttatt tctgcccttc 1500 ccccgcttag gggggcgggg gtaggggaaa ggaaaataat acaatttcag gggaagtcgc 1560 cttcaggtct gctgcttttt tatttttttt tttttaatta aaaaaaaaaa ggacatagaa 1620 aacatcagtc ttgaacttct cttcaagaac ccgggctgca aaggaaatct cctttgtttt 1680 tgttatttat gtgctgtcaa gttttgaagt ggtgatcttt agacagtgac tgagtatgga 1740 tcatttgaac gaggcaactc aggggaaaga acattcagaa atgtctaaca atgtgagtga 1800 tccgaagggt ccaccagcca agattgcccg cctggagcag aacgggagcc cgctaggaag 1860 aggaaggctt gggagtacag gtgcaaaaat gcagggagtg cctttaaaac actcgggcca 1920 tctgatgaaa accaacctta ggaaaggaac catgctgcca gttttctgtg tggtggaaca 1980 ttatgaaaac gccattgaat atgattgcaa ggaggagcat gcagaatttg tgctggtgag 2040 aaaggatatg cttttcaacc agctgatcga aatggcattg ctgtctctag gttattcaca 2100 tagctctgct gcccaggcca aagggctaat ccaggttgga aagtggaatc cagttccact 2160 gtcttacgtg acagatgccc ctgatgctac agtagcagat atgcttcaag atgtgtatca 2220 tgtggtcaca ttgaaaattc agttacacag ttgccccaaa ctagaagact tgcctcccga 2280 acaatggtcg cacaccacag tgaggaatgc tctgaaggac ttactgaaag atatgaatca 2340 gagttcattg gccaaggagt gccccctttc acagagtatg atttcttcca ttgtgaacag 2400 tacttactat gcaaatgtct cagcagcaaa atgtcaagaa tttggaaggt ggtacaaaca 2460 tttcaagaag acaaaagata tgatggttga aatggatagt ctttctgagc tatcccagca 2520 aggcgccaat catgtcaatt ttggccagca accagttcca gggaacacag ccgagcagcc 2580 tccatcccct gcgcagctct cccatggcag ccagccctct gtccggacac ctcttccaaa 2640 cctgcaccct gggctcgtat caacacctat cagtcctcaa ttggtcaacc agcagctggt 2700 gatggctcag ctgctgaacc agcagtatgc agtgaataga cttttagccc agcagtcctt 2760 aaaccaacaa tacttgaacc accctccccc tgtcagtaga tctatgaata agcctttgga 2820 gcaacaggtt tcgaccaaca cagaggtgtc ttccgaaatc taccagtggg tacgcgatga 2880 actgaaacga gcaggaatct cccaggcggt atttgcacgt gtggctttta acagaactca 2940 gggcttgctt tcagaaatcc tccgaaagga agaggacccc aagactgcat cccagtcttt 3000 gctggtaaac cttcgggcta tgcagaattt cttgcagtta ccggaagctg aaagagaccg 3060 aatataccag gacgaaaggg aaaggagctt gaatgctgcc tcggccatgg gtcctgcccc 3120 cctcatcagc acaccaccca gccgtcctcc ccaggtgaaa acagctacta ttgccactga 3180 aaggaatggg aaaccagaga acaataccat gaacattaat gcttccattt atgatgagat 3240 tcagcaggaa atgaagcgtg ctaaagtgtc tcaagcactg tttgcaaagg ttgcagcaac 3300 caaaagccag ggatggttgt gcgagctgtt acgctggaaa gaagatcctt ctccagaaaa 3360 cagaaccctg tgggagaacc tctccatgat ccgaaggttc ctcagtcttc ctcagccaga 3420 acgtgatgcc atttatgaac aggagagcaa cgcggtgcat caccatggcg acaggccgcc 3480 ccacattatc catgttccag cagagcagat tcagcaacag cagcagcaac agcaacagca 3540 gcagcagcag cagcaggcac cgccgcctcc acagccacag cagcagccac agacaggccc 3600 tcggctcccc ccacggcaac ccacggtggc ctctccagca gagtcagatg aggaaaaccg 3660 acagaagacc cggccacgaa caaaaatttc agtggaagcc ttgggaatcc tccagagttt 3720 catacaagac gtgggcctgt accctgacga agaggccatc cagactctgt ctgcccagct 3780 cgaccttccc aagtacacca tcatcaagtt ctttcagaac cagcggtact atctcaagca 3840 ccacggcaaa ctgaaggaca attccggttt agaggtcgat gtggcagaat ataaagaaga 3900 ggagctgctg aaggatttgg aagagagtgt ccaagataaa aatactaaca cccttttttc 3960 agtgaaacta gaagaagagc tgtcagtgga aggaaacaca gacattaata ctgatttgaa 4020 agactgagat aaaagtattt gtttcgttca acagtgccac tggtatttac taacaaaatg 4080 aaaagtccac cttgtcttct ctcagaaaac ctttgttgtt cattgtttgg ccaatgaatc 4140 ttcaaaaact tgcacaaaca gaaaagttgg aaaaggataa tacagactgc actaaatgtt 4200 ttcctctgtt ttacaaactg cttggcagcc ccaggtgaag catcaaggat tgtttggtat 4260 taaaatttgt gttcacggga tgcaccaaag tgtgtacccc gtaagcatga aaccagtgtt 4320 ttttgttttt tttttagttc ttattccgga gcctcaaaca agcattatac cttctgtgat 4380 tatgatttcc tctcctataa ttatttctgt agcactccac actgatcttt ggaaacttgc 4440 cccttattta aaaaaaaaaa agaaaaaaaa gagtttgtta ctctattgta tgttacaaaa 4500 gaactataga ctgtggaatg cagtttaaag atgacatatg ccaacaaatg ccttgtatta 4560 tatggcactg ccgtaattca aatttgtttt tattttggaa ataaaagttc actgtacttt 4620 tttttcattc tcattgttac atgatttttt aaaaaaagga aaagaaaatg tgaaacacaa 4680 tttagtcctc attatttatt tgtagatcct gcagcatcat gttgtaatta attttttgga 4740 agtttccgtt aaatgtaata ttgcttctct tgttaccata ctgattcttt tctatttata 4800 aatgtatttt gatgggcagt aaaacaaagt gtcttaaaag ttttaaatag agaaaatgtg 4860 ctttacacag ttgcctataa aaagtgctct atgttatcca agcaattcat actataagct 4920 tcactcttat tgttgtatgc aatttttact atcatgcaaa taagcttagg taaataaaac 4980 taatagatca ccttagaaaa ttatgcaatt aatgtgaaaa taattgatgt ttgcaatgtg 5040 tcttcctttg gtttacaatc aattttaaag ctacatctgt ataaaatttc tgtataaagg 5100 tgtatttctt ttttatgagt ttatggctat gaaaacagct attttgttac agctggctgt 5160 ttttataagt gtatcacaat tttctttatg cagaaatgtt ctgactagga gtggttattg 5220 actgtaacta cacaattaaa attgtttgta tcgtatgaca tggtagggtt tgtctgctta 5280 tgtgaagtaa ctaaaggagt caaaggatgg ccctctcatt taggtgcatg ttaataactt 5340 gttatttcac tgattttaaa aagagcaatt gacaagttac ttgaaacact gtaaatttaa 5400 atcacaaaca catgctcatt ttt 5423 <210> 21 <211> 6856 <212> DNA <213> Homo sapiens <400> 21 cggtgcattc tgggtcctgg caatatggcg tcctccttga tgggctgatg agatgagttt 60 cactgtagct ccaaaccaga gggcaaagct cccatgaccc aataagccca cattgtccct 120 ttcctccgtg gttccgtgtc gcccgtttct caggactcgt tctcaggcag gagagagcct 180 cggggctgaa ggccaggacc agccaggccg cgcggacctg aggttgagga accgggtgca 240 ggcgagcacg atgggccggt cgtggctctg gttgcagcag ctcagacgag tgcgggaccc 300 gcagggctga gagtggctgg aggagaccca gggccctttg aacccgatcc cttggccgga 360 gacctcagcc cagtcggccc agtgggcgaa ccggcaccaa gagcggcctg cctgtcttcg 420 gaactgctga ggcggtggag gccgagagca gggtcatcgt gaggcctgaa gtctcttacg 480 cttttggcag ctcccctcgc agcccctctg gaaacgtaca gcctcaggag cagccagtgg 540 cttgggacct ggggtggtgt gtgtctgcgg agcttcttgg gctgccccat ttcctagcgg 600 cccccacctc cccacttccc gctcagagtt agagataagg atctcagact tttgcctgag 660 taagggtctc cgcactcttt atccatttgg ttttcgattt cccgtttttg tttcttattt 720 caccaattct ggtacacgct agtttttaag gctggaggtt ctcgagcgct tgctgccaag 780 gactccccca ccccctcccc cactgatgga gtccgaaatg ctgcaatcgc ctcttctggg 840 cctgggggag gaagatgagg ctgatcttac agactggaac ctacctttgg cttttatgaa 900 aaagaggcac tgtgagaaaa ttgaaggctc caaatcctta gctcagagct ggaggatgaa 960 ggatcggatg aagacagtca gtgttgcctt agttttgtgc ctgaatgttg gtgtggaccc 1020 tcccgatgtg gtgaagacca cgccctgtgc acgcttggaa tgctggatcg atcctctgtc 1080 gatgggtcct cagaaagctc tggaaaccat cggtgcaaat ttacagaagc agtacgagaa 1140 ctggcagcca agggcccggt acaagcagag ccttgaccca actgtggatg aagtcaagaa 1200 gctctgcacg tccttacgtc gcaacgccaa ggaggagcga gtcctctttc actacaatgg 1260 ccacggggtg ccccggccca cagtcaacgg ggaggtctgg gtcttcaaca agaactacac 1320 gcagtacatc cctctgtcca tatatgacct gcagacgtgg atgggcagcc cgtcgatctt 1380 cgtctacgac tgctccaatg ctggcttgat cgtcaagtcc ttcaagcagt tcgcactaca 1440 gcgggagcag gagctggagg tagctgcaat caacccaaat caccctcttg ctcagatgcc 1500 tttgcctccg tcgatgaaaa actgcatcca gctggcagcc tgcgaggcca ccgagctgct 1560 gcccatgatc cccgacctcc cggctgacct attcacctcc tgcctcacca cccccatcaa 1620 gatcgccctg cgctggtttt gcatgcagaa atgtgtcagt ctggtgcctg gcgtcacact 1680 ggatttgata gaaaagatcc ctggccgcct gaacgacagg aggacgcccc tgggtgaact 1740 gaactggatc ttcacagcca tcacagacac catcgcgtgg aacgtgctcc cccgggatct 1800 cttccaaaag ctcttcagac aggacttgct ggtggctagt ctgtttcgaa attttttatt 1860 ggcggaaagg attatgaggt cgtataactg cactcccgtc agcagcccgc gtctgccgcc 1920 cacgtacatg cacgccatgt ggcaagcctg ggacctggct gttgacatct gtctgtctca 1980 gctgccgacg atcatcgagg aaggcactgc gtttcggcac agcccgttct tcgccgagca 2040 gctgaccgca ttccaggtgt ggctcaccat gggcgtggag aaccgaaacc cacccgaaca 2100 gctgcccatc gtcctgcagg tgctgttaag ccaagtgcac cggctgagag cattggactt 2160 gcttggaaga tttttggacc tgggtccctg ggcagtgagc ctggccttgt ctgtcggcat 2220 cttcccctac gtgctgaagc tgctccagag ctcggcccga gagctgcggc cacttctcgt 2280 tttcatctgg gccaagatcc tcgcagtgga cagctcgtgc caagcggacc tcgtgaagga 2340 caacggccac aagtacttcc tgtcggtcct ggcggacccc tacatgccag ctgaacaccg 2400 gaccatgacg gctttcattc tcgccgtgat cgtcaacagc tatcacacgg ggcaggaagc 2460 ctgccttcag ggaaacctca ttgccatctg cctggagcag ctcaacgacc cgcacccctt 2520 gctgcgccag tgggtggcca tctgcctcgg caggatctgg cagaacttcg actcggcgag 2580 gtggtgcggc gtgagggaca gcgctcatga gaagctctac agcctcctct ccgaccccat 2640 tcccgaggtc cgctgcgcag cggtcttcgc ccttggcacg ttcgtgggca actctgcaga 2700 gaggacggac cactccacca ccatcgacca caacgtggcc atgatgctgg cccagctggt 2760 cagcgacggg agccccatgg tccggaagga gctggtggtg gctctgagtc atcttgtggt 2820 tcagtatgaa agcaatttct gcaccgtggc cctgcagttc atagaagagg aaaagaacta 2880 cgccttgcct tctccagcaa ccacagaggg agggagtttg accccagtgc gagacagccc 2940 gtgcaccccc agacttcgtt ctgtgagctc ctatggaaac atccgtgctg tcgccacagc 3000 caggagcctc aacaaatctt tgcagaacct gagtttgaca gaggaatctg gtggcgcggt 3060 ggcgttctcc cccggaaacc tcagcaccag cagcagcgcc agcagcaccc tgggcagccc 3120 cgagaatgag gagcatatcc tgtccttcga gaccatcgac aagatgcgcc gcgccagctc 3180 ctactcctcc ctcaactccc tcatcggagt ttcctttaac agtgtttaca ctcagatttg 3240 gagagtcctg ctgcacctgg ctgctgaccc ctatccagag gtctcggacg tggccatgaa 3300 agtactcaac agcatcgcct acaaggccac cgtgaacgcc cggccgcagc gcgtcctgga 3360 cacctcctcc ctcacgcagt cggcccccgc cagccccacc aacaagggcg tgcacatcca 3420 ccaggcgggg ggctcccctc cggcgtccag caccagcagc tccagcctga ccaacgatgt 3480 ggccaagcag ccggtcagcc gagacttgcc ttctggccgg ccgggcacca caggccccgc 3540 tggggcgcag tacacccctc actcccacca gttcccccgg acacggaaga tgttcgacaa 3600 gggcccagag cagactgcgg acgacgcgga cgatgctgct ggacacaaaa gtttcatctc 3660 cgccacggtg cagacggggt tctgcgactg gagcgcccgc tattttgccc agcccgtcat 3720 gaagatccca gaagagcacg acctggagag tcagatccgc aaggagcggg agtggcggtt 3780 cctgcgaaac agccgtgtca ggaggcaggc ccagcaagtc attcagaagg gcattacgag 3840 attggacgac caaatatttc tgaacaggaa ccccggcgtc ccctctgtgg tgaaattcca 3900 ccccttcacg ccgtgcatcg ccgtagccga caaggacagc atctgctttt gggactggga 3960 gaaaggggag aagctggatt atttccacaa tgggaaccct cggtacacga gggtcactgc 4020 catggagtat ctgaacggcc aggactgctc gcttctgctg acggccacag acgatggtgc 4080 catcagggtc tggaagaatt ttgctgattt ggaaaagaac ccagagatgg tgaccgcgtg 4140 gcaggggctc tcggacatgc tgccaacgac gcgaggagct gggatggtgg tggactggga 4200 gcaggagacc ggcctcctca tgagctcagg agacgtgcgg atcgtccgga tctgggacac 4260 agaccgtgag atgaaggtgc aggacatccc tacgggcgca gacagctgtg tgacgagtct 4320 gtcctgtgat tcccaccgct cactcatcgt ggctggcctc ggtgacggct ccatccgcgt 4380 ctacgacaga aggatggcac tcagcgaatg ccgcgtcatg acgtaccggg agcacacagc 4440 ctgggtggtg aaggcctccc tgcagaagcg tcccgacggc cacatcgtga gtgtgagcgt 4500 caatggagat gtgcgcatct ttgatccccg gatgcctgag tcggtaaatg tgcttcagat 4560 cgtgaagggg ctgacggccc tggacatcca cccccaggcg gacctgatcg catgtggctc 4620 cgtcaatcag ttcaccgcca tctacaacag cagcggagag ctcatcaaca acatcaagta 4680 ctacgacggc ttcatgggcc agcgggtcgg cgccatcagc tgcctggcct tccacccgca 4740 ctggcctcac ctggccgtgg gaagcaacga ctactacatc tccgtgtact cggtggagaa 4800 gcgtgtcaga tagcggcgtg acccgggccc accaggccac ggccgcctgc tgtacatagt 4860 gaagctgtca ctcgccgggg cacggggcgt cggctgctgc ggccccgcag tgtgaacgtt 4920 ggctgctgcc ttagctgctg atgacggcag gagggccctg ctactcgctt ttgtctgtct 4980 tcgctgtcgt gtctggaatg tcagggaagg ggagggctcg ggttgacggt ggcttcccac 5040 tgagcaccag catccaggtg cacccccgcg gccacggcgc ctctgtccct ctcctgttct 5100 gtgtttctct gagacgctga aaggggaaac acctcacttt atttccatgt aatcagagca 5160 ttagctgcag aaaaaccccc cgacagagcc ctggcggaga ggcaggcgct ggggctccta 5220 cgggtccctg gggcagctgt ccccatcagg ccaagagcga gcgagaggcg ctgccccagc 5280 caggcccacc acctctcaca gtcagtgcac gcaagcaggg acatttccta gccagctggg 5340 ggacactgga aattcgggaa accaagagag aggaagaagg agacgcccct ccaactggcg 5400 ggtgtgaagg aagccgccca ggggtccggg ctgtccttgg ccgctggcag catcactgag 5460 caggaagcgc acagcccacc ctccccgcac ctccaggtct ctggactcca gttttggccc 5520 ctctcacaca gagctgtcag caggggccgc tgtggcggtg cacaggggag gcaggtcctt 5580 ggcgaggtag cccctgcctt aatccacggg gctcctttcc ctccgaaggg ctgctcttcc 5640 ccacaggcgc ggggacagca gcccgacctg tggtctccat gcctgtgccc tcacacaggt 5700 gtagcacacg catgtgcaga tggcaccacg gccggcacct gggggcacac acatgcaggc 5760 ggcgtggtct ccctgctctg tccccacacg ttcctcacat acaggcaaga ggcactgccg 5820 ggtcccggac ggctccgggt gacaccagcc ccgtctccag ccttgagccg cccatgctga 5880 tgcgacctcg gctgacagct gggcctgtgg tgcagacagg agctgtgtgg acagtcccgc 5940 ccaggagggg ccgcagggcg tgtatgagca gttttgcaaa cagaacacaa ccacaatgat 6000 ggtattttga aaagtgttct ttccgtgttc gtcgggaatc aggattattg agaggtgaag 6060 gagccaggtg gcttcattct ggcggtgaga ggcccacgac cacgggagtg agagctggtg 6120 tggcgaggcc cggctctcct gcggtgtggc tggtggcctg ccgtggccaa gagcatcttc 6180 tgggtggatg gaaccctgcc tggtcacatt tggccagaga cacacctggc cctcaggggg 6240 ctgagctgga gactgagctg gggctggccg ggacgtgaca aggcaggaca gaggcggccc 6300 ctccgctgct cctttttgga atgcgagctc ccaccagaag aaggttccgg cacgaatccc 6360 atccccacgt ctgggccgag aaagcagccc gggtccggaa ggtgtagaga gtcccggcct 6420 cactcagctc acagggcgtg ccaggcggca acaccagaat cttccagaag cccagctcca 6480 cccgcacacg cagcttccca tccagtcctt caactcaatt cttacccaac acgcgtttct 6540 gtttgttttg agacaaaatc accacctgtc aaaaggcagg tggctccaga ggggtcaaga 6600 cccccccccg cccccgctcc accctggagc ccacccccat gggcaccgcg tgccgcctgc 6660 acgtgggctg tcttcacagg tctgatgtga aaattcaatc acgacgttaa ccggctcgag 6720 agagcgccgg cctagaggct cattatctat ttattttacc aaacgcgaat tgagacggac 6780 tttgacaaaa cacgaaatgg taatgtgaag ctaagagcag agagtgacca acagtaaaca 6840 acacgcgcag actccg 6856 <210> 22 <211> 2785 <212> DNA <213> Homo sapiens <400> 22 gatccgccac catggctgaa ggagagaatg aagtgagatg ggatggactc tgcagcagag 60 attcaactac tagggagaca gcattggaaa acattaggca aaccattttg aggaaaaccg 120 agtatcttcg ttcggtgaaa gaaacacctc atcgtccatc agacgggctt tcaaataccg 180 agtcttcgga tgggttgaat aagctacttg ctcatctgct tatgctttct aagaggtgtc 240 ccttcaaaga tgtgagagag aaaagtgagt ttattctgaa gagcatccag gaacttggca 300 ttagaattcc tcgaccacta ggacagggac caagcagatt catcccagaa aaggagatcc 360 tccaagtggg gagtgaagac gcacagatgc atgctttatt tgcagattct tttgctgctt 420 tgggccgttt ggataacatt acgttagtga tggttttcca cccacaatat ttagaaagtt 480 tcttaaaaac tcagcactat ctactgcaaa tggatgggcc gttaccccta cattatcgtc 540 actacattgg aataatggct gcggcaagac atcagtgctc ctacttagtg aacctgcatg 600 taaatgattt ccttcatgtt ggtggggacc ccaagtggct caatggttta gagaatgctc 660 ctcaaaaact acagaattta ggagaactta acaaagtgtt agcccataga ccttggctta 720 ttaccaaaga acacattgag ggacttttaa aagctgaaga gcacagctgg tcccttgcgg 780 aattggtaca tgcagtagtt ttactcacac actatcattc tcttgcctca ttcacattcg 840 gctgtggaat cagtccagaa attcattgtg atggtggcca cacattcaga cctccttctg 900 ttagcaacta ctgcatctgt gacattacaa atggcaatca cagtgtggat gagatgccgg 960 tcaactcagc agaaaatgtt tctgtaagtg attctttctt tgaggttgaa gccctcatgg 1020 aaaagatgag gcagttacag gaatgtcgag atgaagaaga ggcaagtcag gaagagatgg 1080 cttcacgttt tgaaatagaa aaaagagaga gtatgtttgt cttctcttca gatgatgaag 1140 aagttacacc agcaagagct gtatctcgtc attttgagga tactagttat ggctataaag 1200 atttctctag acatgggatg catgttccaa catttcgtgt ccaggactat tgctgggaag 1260 atcatggtta ttctttggta aatcgccttt atccagatgt gggacagttg attgatgaaa 1320 aatttcacat tgcttacaat cttacttata atacaatggc aatgcacaaa gatgttgata 1380 cctcaatgct tagacgggca atttggaact atattcactg catgtttgga ataagatatg 1440 atgattatga ctatggtgaa attaaccagc tattggatcg tagctttaaa gtttatatca 1500 aaactgttgt ttgcactcct gaaaaggtta ccaaaagaat gtatgatagc ttctggaggc 1560 agttcaagca ctctgagaag gttcatgtta atctgcttct tatagaagct aggatgcaag 1620 cagaactcct ttatgctctg agagccatta cccgctatat gacctgatgc ctttccttca 1680 ttaaagatga ttctggaatg atcagcagat atagtctaca agggggaagg tactaagccc 1740 caggaccaat ggtagacaaa ataattcaga aatccattgt gccatgattc ctttagtttc 1800 tgctattttt ctgtggaaaa ccactgctgg cacaagcagt gactgtttgg cagcttcaag 1860 tttagagctg tgaagacagg ctgccattca cagtattttg ctttttgaca gtacaagatg 1920 ctgtgtaact gttttaatac agcaaatagt aactctccaa atcctgttgc ttttatgtta 1980 aataagataa caagaattgg agcatgcaaa gaatgggact tggataatga cttaagcttt 2040 atatgtaaag aattttagaa gatcttggtg ctgctattcc tgctggagga atgaatagat 2100 ggctgtttca gttaagctat tagtaataaa agtgaacatt gctactatct gagcctacat 2160 acataacttg tgtgatttca aattaaactt gcattatgtg ttaattttct tgcatctaaa 2220 aaagcataga attcctactc acacagctca gcaacaacca ttttgatggt aacagttaat 2280 ttctttcatt agttttttaa attcagggtt ctggatatta aattaaaatg gcattcttaa 2340 agattttctt caaaaagcaa tcctaaatga aagtgtgtaa attataagaa gctggcgatc 2400 ttttgatatg ctgtttcaca ggatcctgac actggagggc agctgtcttg tgcattactt 2460 gtgttcccag caccaaagtt gtgggacatg ttgctgtaga ctgctgcgca gtcctgggtg 2520 cattcagtct ctctgcctct gcctgcctcc tggtccccac tttaaaggct gtgcagctcc 2580 ttaaataata aagctggaaa atatttttag tcgggttatc aaatttgatt tacaaaaacg 2640 ctaactttgt ttgaaatgca aacaggtttg aaaatatgta ttaagtactt tgtattctgg 2700 aagcgtgaat tgcttttgaa gtctgtcagt attactggta tttttaaata aagaagaatt 2760 tttctccaaa aaaaaaaaaa aaaaa 2785 <210> 23 <211> 5489 <212> DNA <213> Homo sapiens <400> 23 gaaactctta acaaaaacaa ggggctcggg gaggtttccg ctgaggcggc gggggtgcgg 60 cggtgggctg gtcttccgcg gccggcgttg cgccgcggcg gagggtgggc gcgcggggag 120 cgggatggag ccggggctgt gaggccgagg cggcggtgcc tgggaggaag ggtcggatgc 180 cggaccgggg gcaccgctga ggcggtgggt ccccgacctg cgagacaggt ttggaagccc 240 ccgctgcgcc cagtccgtgc ggaccgcgag gccgcgggcg ggtggaggcg cgtctccggc 300 acgatgaagg atttgggggc agagcacttg gcaggtcatg aaggggtcca acttctcggg 360 ttgttgaacg tctacctgga acaagaagag agattccaac ctcgagaaaa agggctgagt 420 ttgattgagg ctaccccgga gaatgataac actttgtgtc caggattgag aaatgccaaa 480 gttgaagatt taaggagttt agccaacttt tttggatctt gcactgaaac ttttgtcctg 540 gctgtcaata ttttggacag gttcttggct cttatgaagg tgaaacctaa acatttgtct 600 tgcattggag tctgttcttt tttgctggct gctagaatag ttgaagaaga ctgcaatatt 660 ccatccactc atgatgtgat ccggattagt cagtgtaaat gtactgcttc tgacataaaa 720 cggatggaaa aaataatttc agaaaaattg cactatgaat tggaagctac tactgcctta 780 aactttttgc acttatacca tactattata ctttgtcata cttcagaaag gaaagaaata 840 ctgagccttg ataaactaga agctcagctg aaagcttgca actgccgact catcttttca 900 aaagcaaaac catctgtatt agccttgtgc cttctcaatt tggaagtgga aactttgaaa 960 tctgttgaat tactggaaat tctcttgcta gttaaaaaac attccaagat taatgacact 1020 gagttcttct actggagaga gttggtttct aaatgcctag ccgagtattc ttctcctgaa 1080 tgttgcaaac cagatcttaa gaagttggtt tggatcgttt caaggcgcac agcccagaac 1140 ctccacaaca gctactatag tgttcctgag ctgccaacga tacctgaggg gggttgtttt 1200 gatgaaagtg aaagtgagga ctcttgtgaa gatatgagtt gtggagagga gagtctcagc 1260 agctctcctc ccagtgatca agagtgcacc ttctttttca acttcaaagt ggcacaaaca 1320 ctgtgctttc catcttagaa atctgattgt tctgtcagaa tttatattta caggtttcaa 1380 agcaataaat gggggaatag gtagtttcct ggtttagccc ccatctagtc aggaattaat 1440 atactggaat acctaccttc tatttgttat tcagatcaga tctggcctat tttcatattt 1500 atcctaagcc atcaaatggg gtagtgcctc ttaaaccatt aacagtactt tagacattgg 1560 cactttattt ttctcgtaga tctttagcta ctttggggag gagggaaggt gctgatacct 1620 tcaatttgtt acttttcaag atttttaaaa ataactagtg tagcttatct taaacatttt 1680 ataaaacctt cagatgtctt taagcagatt ggaagtatgc aagtgcttcc ttagcaggga 1740 cagtggataa tccttaatgg tttatcatag atttcaccct ccccccttct cagaagagtg 1800 agtatgctct taaatgtcaa acacattttt gttgttttgt tttttaaatg atcagtgtct 1860 atttgatgtg atgcagatct tataaatttg ggaattataa tattgacatt tctgtgattt 1920 ttatatatgt aatgtcttaa ttgagatttc tgttaaggca gaaataatta ggctagggct 1980 cttagttttc attcctattg cccaagtatt gtcaaactat ggtattattt taatgttact 2040 ttaaaaatcc ataatctgct agttttgcat gtacttatat gaaaacagtg cagtaagttg 2100 aaaactcagt atctatggaa ttgataaatg ttgatctggt gtagtatatt ttatcgcatt 2160 ttcttatatt aaaaaatgtc tgcatgatta cattttattt cctttgtaat ttacatttca 2220 gaatagtgta ttgctatatg ggtgccaaga ttgaatatga agaacccgag tgtttgtagt 2280 attatagttt taagcaaatc tgtgtggtga tacagccata agaatggggc ttatataaac 2340 tctgtacatg taagattttg tacagagaat ttttaacttt ataaattgta tatgaacatg 2400 taaatctttt aaaatgtaca taaaatactg tattttttta ccttgtgtgt gatagtctag 2460 tcattgcatg taaatataat ttattatgta ttctgtagta taaatcatac attgatgact 2520 tacattttta ctggtaagtc aacatccgtt ggatgttttc tgaagtggct ctttttgaag 2580 tgataataga ttgtaattca aaataaaatt attaatgaat tctccttgtt tgggatcaca 2640 tcttaatttt taatctgtta aaagttcttg atgtatttta atgagaagac tttaggtgag 2700 gctacagtga ttccagagtg agccttctaa ctggctagca gaagttctct aggtttggca 2760 tctgtgcctt ggagatactg aaagagaatc tgtcatttga caattgacct ctttgtggga 2820 tggactcatt aagtatgctc tcagagactg gtatattacc agaatgccta ttaattttca 2880 gtgagaggca acaggtatta agtagaacag aatgctcagg ttggcagatt agaacgatct 2940 ttcaggagac aaagcaagtt ttaatcagtt gtttggttaa taagtatggg gtgttcgctg 3000 tgatagggcc ccgccagctt ctggctcttg tggacctcaa aagtatcagg tggttttgca 3060 agtggtggtc ctttcccctg ccccacccca ataggttccc catctgtcta gtttgatttt 3120 tgtagacctt tgttttctct agttagaaaa tcaggtacac tgaatatggt tttcatgtaa 3180 cacctcttct ctggagatag gggtatgttt tcctaccctt ctagtggaga atcctacttg 3240 aggatgacct ttcctctctt actaaataat attagtaaat agtgggcaat atattctgct 3300 ttcagatttt gatttgttga gatgtaaaag ttgtttgggg cttaccaaat ctcaagactc 3360 tctttagctc ctgcaggatt gtattgcttt tcttactgga tatttttcct gggtaagcat 3420 ctttgtggct tcatctcttc cccctgtggt tttcagtgta tttagtcgag acctctctgc 3480 tgagcttgca acctgtttat tcacatggcc tgccatgcca cttggaggtt tctgattact 3540 cccaaacctg ctggttcttt atgtctttct cagcgaataa ttccatctat tcatgttgga 3600 aacttaggtg atatgctcat ctccttttgc ctgtttatgg aggtcaccag cctctatcat 3660 ttgtatgatt tcgtttacac tgtttatatc tctctgtccc ccctttttct gccattggca 3720 tggtttagac ctgtactctt tatcagcaga ggtactgtaa tatatttgtg atccctcagc 3780 ttccaggctt actcctggtc tctgccttcc tatctacata tccttttaaa ataaaatttt 3840 aactatctcc tgaaaaattg ttgagtaggt cacgcacaat caggagaaaa atctattcat 3900 gacatacaag tctctgtcta atctgaacac tgcacctgtc tctggccttt ttttcttgtc 3960 atttcctaga ccttaaaaaa tgtgtattga gaaagaactc tgttagctat acagaagatg 4020 aactgggcaa tatagagtag cagcatggag accagtctga ctgaactaag gcagtggaag 4080 tgtggatgag gaagagaggt gaaaattgag aagcgctatc ctttctcttt gggcattatt 4140 aggaggctca cagacaagtc caggagcctg gttataccct cctgtgccat tcaaccaggt 4200 ggctttccca tgactgtgat gaataaaatt gagaagcccc tgcccttttc agagcagagg 4260 gtgaggagaa agctaccatt ttgtcctcat ccttaccccc gttgacttgg cgagagattt 4320 gacctttcag gttttgatcc tgtcattttc taggatgtgg tgcacgcact ttgctgttgc 4380 gcatggtgaa gtattgtgcc taggtcctgg gtcttcatct gtttggctct gctactgttt 4440 cctcctccca ggaagtgtgg ttagacaaat aatgtgtttt aattacctgt cacactcagg 4500 attaatacat actcaggtta actgtagaga ggcattggct tcagaacact cctcgtgaca 4560 attttaacca ttttctttgt ctagagtctg cctttttctt ttttacaatt tcttttattt 4620 caacactagg tttcaatatg gtgttcctgc tacctcccac ctccctcctc cctcatcaca 4680 catgcaaatt gtcagcttat tgagacaacc cacttagatt catatatgga caaggacaag 4740 gtattttgca tttgttactg gaattcagtt ttcctaacta tttactacca gaaatggtca 4800 ataacttact ttgtgtttag caaatcaaat tgtgtgatag atagtttccc agtatgatgg 4860 ccagtcagtc tttccatccc tgtgcctaca tgctgctctt cccgtccaca agtggagtct 4920 gtttctcttg agttttggct ggccttatga atggctttgc ttactgaagt gcagcagaag 4980 aaatttagta tatgtccaag cctaggcttt aagagactgg cagctttcct tttatccttt 5040 ttggaagcta gccaccatgc tgcaaagaag ctcagctgga ttactgaaag atgagaggcc 5100 atgtggagag agactcttga ggatgagaga ttatcttgga tgttccagcc ttaagctccc 5160 agctgaatgt gggtgtatcc tcagctacac cacagaaaac agaggaacta ctcagtcgat 5220 cccaatcaac ccacagactc actagaaata acaaattatt gttttaagcc acgaggtttt 5280 gggggagggt tgttaaacag taatagataa gtgagacaga ttgcttgtta tttatggtca 5340 aatggtgatt atctctggtg agattacagg tgatgttttt tttaagttat gcctatctgt 5400 agtttccttt ttttcctaaa attgatttga attattagtg tattaacaga ataaagaatg 5460 aactttaaaa cacaaaaaaa aaaaaaaaa 5489 <210> 24 <211> 4815 <212> DNA <213> Homo sapiens <400> 24 agtggcgtcg gaactgcaaa gcacctgtga gcttgcggaa gtcagttcag actccagccc 60 gctccagccc ggcccgaccc gaccgcaccc ggcgcctgcc ctcgctcggc gtccccggcc 120 agccatgggc ccttggagcc gcagcctctc ggcgctgctg ctgctgctgc aggtctcctc 180 ttggctctgc caggagccgg agccctgcca ccctggcttt gacgccgaga gctacacgtt 240 cacggtgccc cggcgccacc tggagagagg ccgcgtcctg ggcagagtga attttgaaga 300 ttgcaccggt cgacaaagga cagcctattt ttccctcgac acccgattca aagtgggcac 360 agatggtgtg attacagtca aaaggcctct acggtttcat aacccacaga tccatttctt 420 ggtctacgcc tgggactcca cctacagaaa gttttccacc aaagtcacgc tgaatacagt 480 ggggcaccac caccgccccc cgccccatca ggcctccgtt tctggaatcc aagcagaatt 540 gctcacattt cccaactcct ctcctggcct cagaagacag aagagagact gggttattcc 600 tcccatcagc tgcccagaaa atgaaaaagg cccatttcct aaaaacctgg ttcagatcaa 660 atccaacaaa gacaaagaag gcaaggtttt ctacagcatc actggccaag gagctgacac 720 accccctgtt ggtgtcttta ttattgaaag agaaacagga tggctgaagg tgacagagcc 780 tctggataga gaacgcattg ccacatacac tctcttctct cacgctgtgt catccaacgg 840 gaatgcagtt gaggatccaa tggagatttt gatcacggta accgatcaga atgacaacaa 900 gcccgaattc acccaggagg tctttaaggg gtctgtcatg gaaggtgctc ttccaggaac 960 ctctgtgatg gaggtcacag ccacagacgc ggacgatgat gtgaacacct acaatgccgc 1020 catcgcttac accatcctca gccaagatcc tgagctccct gacaaaaata tgttcaccat 1080 taacaggaac acaggagtca tcagtgtggt caccactggg ctggaccgag agagtttccc 1140 tacgtatacc ctggtggttc aagctgctga ccttcaaggt gaggggttaa gcacaacagc 1200 aacagctgtg atcacagtca ctgacaccaa cgataatcct ccgatcttca atcccaccac 1260 gtacaagggt caggtgcctg agaacgaggc taacgtcgta atcaccacac tgaaagtgac 1320 tgatgctgat gcccccaata ccccagcgtg ggaggctgta tacaccatat tgaatgatga 1380 tggtggacaa tttgtcgtca ccacaaatcc agtgaacaac gatggcattt tgaaaacagc 1440 aaagggcttg gattttgagg ccaagcagca gtacattcta cacgtagcag tgacgaatgt 1500 ggtacctttt gaggtctctc tcaccacctc cacagccacc gtcaccgtgg atgtgctgga 1560 tgtgaatgaa gcccccatct ttgtgcctcc tgaaaagaga gtggaagtgt ccgaggactt 1620 tggcgtgggc caggaaatca catcctacac tgcccaggag ccagacacat ttatggaaca 1680 gaaaataaca tatcggattt ggagagacac tgccaactgg ctggagatta atccggacac 1740 tggtgccatt tccactcggg ctgagctgga cagggaggat tttgagcacg tgaagaacag 1800 cacgtacaca gccctaatca tagctacaga caatggttct ccagttgcta ctggaacagg 1860 gacacttctg ctgatcctgt ctgatgtgaa tgacaacgcc cccataccag aacctcgaac 1920 tatattcttc tgtgagagga atccaaagcc tcaggtcata aacatcattg atgcagacct 1980 tcctcccaat acatctccct tcacagcaga actaacacac ggggcgagtg ccaactggac 2040 cattcagtac aacgacccaa cccaagaatc tatcattttg aagccaaaga tggccttaga 2100 ggtgggtgac tacaaaatca atctcaagct catggataac cagaataaag accaagtgac 2160 caccttagag gtcagcgtgt gtgactgtga aggggccgct ggcgtctgta ggaaggcaca 2220 gcctgtcgaa gcaggattgc aaattcctgc cattctgggg attcttggag gaattcttgc 2280 tttgctaatt ctgattctgc tgctcttgct gtttcttcgg aggagagcgg tggtcaaaga 2340 gcccttactg cccccagagg atgacacccg ggacaacgtt tattactatg atgaagaagg 2400 aggcggagaa gaggaccagg actttgactt gagccagctg cacaggggcc tggacgctcg 2460 gcctgaagtg actcgtaacg acgttgcacc aaccctcatg agtgtccccc ggtatcttcc 2520 ccgccctgcc aatcccgatg aaattggaaa ttttattgat gaaaatctga aagcggctga 2580 tactgacccc acagccccgc cttatgattc tctgctcgtg tttgactatg aaggaagcgg 2640 ttccgaagct gctagtctga gctccctgaa ctcctcagag tcagacaaag accaggacta 2700 tgactacttg aacgaatggg gcaatcgctt caagaagctg gctgacatgt acggaggcgg 2760 cgaggacgac taggggactc gagagaggcg ggccccagac ccatgtgctg ggaaatgcag 2820 aaatcacgtt gctggtggtt tttcagctcc cttcccttga gatgagtttc tggggaaaaa 2880 aaagagactg gttagtgatg cagttagtat agctttatac tctctccact ttatagctct 2940 aataagtttg tgttagaaaa gtttcgactt atttcttaaa gctttttttt ttttcccatc 3000 actctttaca tggtggtgat gtccaaaaga tacccaaatt ttaatattcc agaagaacaa 3060 ctttagcatc agaaggttca cccagcacct tgcagatttt cttaaggaat tttgtctcac 3120 ttttaaaaag aaggggagaa gtcagctact ctagttctgt tgttttgtgt atataatttt 3180 ttaaaaaaaa tttgtgtgct tctgctcatt actacactgg tgtgtccctc tgcctttttt 3240 ttttttttaa gacagggtct cattctatcg gccaggctgg agtgcagtgg tgcaatcaca 3300 gctcactgca gccttgtcct cccaggctca agctatcctt gcacctcagc ctcccaagta 3360 gctgggacca caggcatgca ccactacgca tgactaattt tttaaatatt tgagacgggg 3420 tctccctgtg ttacccaggc tggtctcaaa ctcctgggct caagtgatcc tcccatcttg 3480 gcctcccaga gtattgggat tacagacatg agccactgca cctgcccagc tccccaactc 3540 cctgccattt tttaagagac agtttcgctc catcgcccag gcctgggatg cagtgatgtg 3600 atcatagctc actgtaacct caaactctgg ggctcaagca gttctcccac cagcctcctt 3660 tttatttttt tgtacagatg gggtcttgct atgttgccca agctggtctt aaactcctgg 3720 cctcaagcaa tccttctgcc ttggcccccc aaagtgctgg gattgtgggc atgagctgct 3780 gtgcccagcc tccatgtttt aatatcaact ctcactcctg aattcagttg ctttgcccaa 3840 gataggagtt ctctgatgca gaaattattg ggctctttta gggtaagaag tttgtgtctt 3900 tgtctggcca catcttgact aggtattgtc tactctgaag acctttaatg gcttccctct 3960 ttcatctcct gagtatgtaa cttgcaatgg gcagctatcc agtgacttgt tctgagtaag 4020 tgtgttcatt aatgtttatt tagctctgaa gcaagagtga tatactccag gacttagaat 4080 agtgcctaaa gtgctgcagc caaagacaga gcggaactat gaaaagtggg cttggagatg 4140 gcaggagagc ttgtcattga gcctggcaat ttagcaaact gatgctgagg atgattgagg 4200 tgggtctacc tcatctctga aaattctgga aggaatggag gagtctcaac atgtgtttct 4260 gacacaagat ccgtggtttg tactcaaagc ccagaatccc caagtgcctg cttttgatga 4320 tgtctacaga aaatgctggc tgagctgaac acatttgccc aattccaggt gtgcacagaa 4380 aaccgagaat attcaaaatt ccaaattttt ttcttaggag caagaagaaa atgtggccct 4440 aaagggggtt agttgagggg tagggggtag tgaggatctt gatttggatc tctttttatt 4500 taaatgtgaa tttcaacttt tgacaatcaa agaaaagact tttgttgaaa tagctttact 4560 gtttctcaag tgttttggag aaaaaaatca accctgcaat cactttttgg aattgtcttg 4620 atttttcggc agttcaagct atatcgaata tagttctgtg tagagaatgt cactgtagtt 4680 ttgagtgtat acatgtgtgg gtgctgataa ttgtgtattt tctttggggg tggaaaagga 4740 aaacaattca agctgagaaa agtattctca aagatgcatt tttataaatt ttattaaaca 4800 attttgttaa accat 4815 <210> 25 <211> 1909 <212> DNA <213> Homo sapiens <400> 25 gaggtgtttc ccttagctat ggaaactcta taagagagat ccagcttgcc tcctcttgag 60 cagtcagcaa cagggtcccg tccttgacac ctcagcctct acaggactga gaagaagtaa 120 aaccgtttgc tggggctggc ctgactcacc agctgccatg cagcagccct tcaattaccc 180 atatccccag atctactggg tggacagcag tgccagctct ccctgggccc ctccaggcac 240 agttcttccc tgtccaacct ctgtgcccag aaggcctggt caaaggaggc caccaccacc 300 accgccaccg ccaccactac cacctccgcc gccgccgcca ccactgcctc cactaccgct 360 gccacccctg aagaagagag ggaaccacag cacaggcctg tgtctccttg tgatgttttt 420 catggttctg gttgccttgg taggattggg cctggggatg tttcagctct tccacctaca 480 gaaggagctg gcagaactcc gagagtctac cagccagatg cacacagcat catctttgga 540 gaagcaaata ggccacccca gtccaccccc tgaaaaaaag gagctgagga aagtggccca 600 tttaacaggc aagtccaact caaggtccat gcctctggaa tgggaagaca cctatggaat 660 tgtcctgctt tctggagtga agtataagaa gggtggcctt gtgatcaatg aaactgggct 720 gtactttgta tattccaaag tatacttccg gggtcaatct tgcaacaacc tgcccctgag 780 ccacaaggtc tacatgagga actctaagta tccccaggat ctggtgatga tggaggggaa 840 gatgatgagc tactgcacta ctgggcagat gtgggcccgc agcagctacc tgggggcagt 900 gttcaatctt accagtgctg atcatttata tgtcaacgta tctgagctct ctctggtcaa 960 ttttgaggaa tctcagacgt ttttcggctt atataagctc taagagaagc actttgggat 1020 tctttccatt atgattcttt gttacaggca ccgagaatgt tgtattcagt gagggtcttc 1080 ttacatgcat ttgaggtcaa gtaagaagac atgaaccaag tggaccttga gaccacaggg 1140 ttcaaaatgt ctgtagctcc tcaactcacc taatgtttat gagccagaca aatggaggaa 1200 tatgacggaa gaacatagaa ctctgggctg ccatgtgaag agggagaagc atgaaaaagc 1260 agctaccagg tgttctacac tcatcttagt gcctgagagt atttaggcag attgaaaagg 1320 acacctttta actcacctct caaggtgggc cttgctacct caagggggac tgtctttcag 1380 atacatggtt gtgacctgag gatttaaggg atggaaaagg aagactagag gcttgcataa 1440 taagctaaag aggctgaaag aggccaatgc cccactggca gcatcttcac ttctaaatgc 1500 atatcctgag ccatcggtga aactaacaga taagcaagag agatgttttg gggactcatt 1560 tcattcctaa cacagcatgt gtatttccag tgcaattgta ggggtgtgtg tgtgtgtgtg 1620 tgtgtgtgtg tgtgtatgac taaagagaga atgtagatat tgtgaagtac atattaggaa 1680 aatatgggtt gcatttggtc aagattttga atgcttcctg acaatcaact ctaatagtgc 1740 ttaaaaatca ttgattgtca gctactaatg atgttttcct ataatataat aaatatttat 1800 gtagatgtgc atttttgtga aatgaaaaca tgtaataaaa agtatatgtt aggatacaaa 1860 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa 1909 <210> 26 <211> 2689 <212> DNA <213> Homo sapiens <400> 26 acatctcccg gcggcgggcc gcggaagcag tgcagacgcg gctcctagcg gatgggtgct 60 attgtgaggc ggttgtagaa gagtttcgtg agtgctcgca gctcatacct gtggctgtgt 120 atccgtggcc acagctggtt ggcgtcgcct tgaaatccca ggccgtgagg agttagcgag 180 ccctgctcac actcggcgct ctggttttcg gtgggtgtgc cctgcacctg cctcttcccc 240 cattctcatt aataaaggta tccatggaga acactgaaaa ctcagtggat tcaaaatcca 300 ttaaaaattt ggaaccaaag atcatacatg gaagcgaatc aatggactct ggaatatccc 360 tggacaacag ttataaaatg gattatcctg agatgggttt atgtataata attaataata 420 agaattttca taaaagcact ggaatgacat ctcggtctgg tacagatgtc gatgcagcaa 480 acctcaggga aacattcaga aacttgaaat atgaagtcag gaataaaaat gatcttacac 540 gtgaagaaat tgtggaattg atgcgtgatg tttctaaaga agatcacagc aaaaggagca 600 gttttgtttg tgtgcttctg agccatggtg aagaaggaat aatttttgga acaaatggac 660 ctgttgacct gaaaaaaata acaaactttt tcagagggga tcgttgtaga agtctaactg 720 gaaaacccaa acttttcatt attcaggcct gccgtggtac agaactggac tgtggcattg 780 agacagacag tggtgttgat gatgacatgg cgtgtcataa aataccagtg gaggccgact 840 tcttgtatgc atactccaca gcacctggtt attattcttg gcgaaattca aaggatggct 900 cctggttcat ccagtcgctt tgtgccatgc tgaaacagta tgccgacaag cttgaattta 960 tgcacattct tacccgggtt aaccgaaagg tggcaacaga atttgagtcc ttttcctttg 1020 acgctacttt tcatgcaaag aaacagattc catgtattgt ttccatgctc acaaaagaac 1080 tctattttta tcactaaaga aatggttggt tggtggtttt ttttagtttg tatgccaagt 1140 gagaagatgg tatatttggt actgtatttc cctctcattt tgacctactc tcatgctgca 1200 gagggtactt taagacatac tccttccatc aaatagaacc actatgaagc tacctcaaac 1260 ttccagtcag gtagttgcaa ttgaattaaa ttaggaataa ataaaaatgg atactggtgc 1320 agtcattatg agaggcaatg attgttaatt tacagctttc atgattagca agttacagtg 1380 atgctgtgct atgaattttc aagtaattgt gaaaaagtta aacattgaag taatgaattt 1440 ttatgatatt ccccccactt aagactgtgt attctagttt tgtcaaactg tagaaatgat 1500 gatgtggaag aacttaggca tctgtgggca tggtcaaagg ctcaaacctt tattttagaa 1560 ttgatataca cggatgactt aactgcattt ttagaccatt tatctgggat tatggttttg 1620 tgatgtttgt cctgaacact tttgttgtaa aaaaataata ataatgttta atattgagaa 1680 agaaactaat attttatgtg agagaaagtg tgagcaaact aacttgactt ttaaggctaa 1740 aacttaacat tcatagaggg gtggagtttt aactgtaagg tgctacaatg cccctggatc 1800 taccagcata aatatcttct gatttgtccc tatgcatatc agttgagctt catataccag 1860 caatatatct gaagagctat tatataaaaa ccccaaactg ttgattatta gccaggtaat 1920 gtgaataaat tctataggaa catatgaaaa tacaacttaa ataataaaca gtggaatata 1980 aggaaagcaa taaatgaatg ggctgagctg cctgtaactt gagagtagat ggtttgagcc 2040 tgagcagaga catgactcag cctgttccat gaaggcagag ccatggacca cgcaggaagg 2100 gcctacagcc catttctcca tacgcactgg tatgtgtgga tgatgctgcc agggcgccat 2160 cgccaagtaa gaaagtgaag caaatcagaa acttgtgaag tggaaatgtt ctaaaggtgg 2220 tgaggcaata aaaatcatag tactctttgt agcaaaattc ttaagtatgt tattttctgt 2280 tgaagtttac aatcaaagga aaatagtaat gttttatact gtttactgaa agaaaaagac 2340 ctatgagcac ataggactct agacggcatc cagccggagg ccagagctga gccctcagcc 2400 cgggaggcag gctccaggcc tcagcaggtg cggagccgtc actgcaccaa gtctcactgg 2460 ctgtcagtat gacatttcac gggagatttc ttgttgctca aaaaatgagc tcgcatttgt 2520 caatgacagt ttcttttttc ttactagacc tgtaactttt gtaaatacac atagcatgta 2580 atggtatctt aaagtgtgtt tctatgtgac aattttgtac aaatttgtta ttttccattt 2640 ttatttcaaa atatacattc aaacttaaaa ttaaaaaaaa aaaaaaaaa 2689 <210> 27 <211> 2143 <212> DNA <213> Homo sapiens <400> 27 ggaagttttc cggcggctac cgggaagtcg ctgaagacag agcgatggta gttctggagg 60 cctcgctccg gggccgaccc gaggccacag tgcctccgcg gtagaccgga cttgggtgac 120 gggctccggg ctcccgaggt gaagagcatc gggggctgag ggatggaagg gtctaagacg 180 tccaacaaca gcaccatgca ggtgagcttc gtgtgccagc gctgcagcca gcccctgaaa 240 ctggacacga gtttcaagat cctggaccgt gtcaccatcc aggaactcac agctccatta 300 cttaccacag cccaggcgaa accaggagag acccaggagg aagagactaa ctcaggagag 360 gagccattta ttgaaactcc tcgccaggat ggtgtctctc gcagattcat ccccccagcc 420 aggatgatgt ccacagaaag tgccaacagc ttcactctga ttggggaggc atctgatggc 480 ggcaccatgg agaacctcag ccgaagactg aaggtcactg gggacctttt tgacatcatg 540 tcgggccaga cagatgtgga tcacccactc tgtgaggaat gcacagatac tcttttagac 600 cagctggaca ctcagctcaa cgtcactgaa aatgagtgtc agaactacaa acgctgtttg 660 gagatcttag agcaaatgaa tgaggatgac agtgaacagt tacagatgga gctaaaggag 720 ctggcactag aggaggagag gctgatccag gagctggaag acgtggaaaa gaaccgcaag 780 atagtggcag aaaatctcga gaaggtccag gctgaggctg agagactgga tcaggaggaa 840 gctcagtatc agagagaata cagtgaattt aaacgacagc agctggagct ggatgatgag 900 ctgaagagtg ttgaaaacca gatgcgttat gcccagacgc agctggataa gctgaagaaa 960 accaacgtct ttaatgcaac cttccacatc tggcacagtg gacagtttgg cacaatcaat 1020 aacttcaggc tgggtcgcct gcccagtgtt cccgtggaat ggaatgagat taatgctgct 1080 tggggccaga ctgtgttgct gctccatgct ctggccaata agatgggtct gaaatttcag 1140 agataccgac ttgttcctta cggaaaccat tcatatctgg agtctctgac agacaaatct 1200 aaggagctgc cgttatactg ttctgggggg ttgcggtttt tctgggacaa caagtttgac 1260 catgcaatgg tggctttcct ggactgtgtg cagcagttca aagaagaggt tgagaaaggc 1320 gagacacgtt tttgtcttcc ctacaggatg gatgtggaga aaggcaagat tgaagacaca 1380 ggaggcagtg gcggctccta ttccatcaaa acccagttta actctgagga gcagtggaca 1440 aaagctctca agttcatgct gacgaatctt aagtggggtc ttgcttgggt gtcctcacaa 1500 ttttataaca aatgactttt ttccttaggg ggaggtttgc cttaaaggct tttaattttg 1560 ttttgtttgc aaacatgttt taaattaaat tcgggtaata ttaaacagta catgtttaca 1620 ataccaaaaa agaaaaaatc cacaaaagcc actttatttt aaaatatcat gtgacagata 1680 ctttccagag ctacaacatg ccatctatag ttgccagccc tggtcagttt tgattcttaa 1740 ccccatggac tcctttccct ttcttctctg aaaaaaacta atttaaattt gcttttcttt 1800 tttttaactg agttgaattg agattgatgt gttttcactg gatttttatc tctctcaact 1860 tcctgcactt aacaatatga aatagaaact tttgtcttta ctgagatgag gatatgtttg 1920 agatgcacag ttggataatg tgggaaaatg acatctaagc tttacctggt caccatgtga 1980 tgtgatcaga tgcttgaaat ttaacacttt tcacttggtt cttatactga atgccgactc 2040 tgctctgtgt tagagatatg aaatggtgtt tgatactgtt tgagacatta tggagagatt 2100 taattatttg taataaaaga tttgctgcag tctgaaaact gcc 2143 <210> 28 <211> 4380 <212> DNA <213> Homo sapiens <400> 28 ggggagcgcc atccgctcca cttccacctc cacatcctcc accggccaag gtccccgccg 60 ctgcatccct cgcggcttcc gctgcgctcc gggccggagc cgagccgcct gcgctgccac 120 agcagccgcc tccacacact cgcagacgct cacacgctct ccctccctgt tcccccgccc 180 cctccccagc tccttgatct ctgggtctgt tttattactc ctggtgcgag tcccgcggac 240 tccgcggccc gctatttgtc atcagctcgc tctccattgg cggggagcgg agagcagcga 300 agaagggggt ggggagggga ggggaaggga agggggtgga aactgcctgg agccgtttct 360 ccgcgccgct gttggtgctg ccgctgcctc ctcctcctcc gccgccgccg ccgccgccgc 420 cgcctcctcc ggctcttcgc tcggcccctc tccgcctcca tgtgccggat agcgggagcg 480 ctgcggaccc tgctgccgct gctggcggcc ctgcttcagg cgtctgtaga ggcttctggt 540 gaaatcgcat tatgcaagac tggatttcct gaagatgttt acagtgcagt cttatcgaag 600 gatgtgcatg aaggacagcc tcttctcaat gtgaagttta gcaactgcaa tggaaaaaga 660 aaagtacaat atgagagcag tgagcctgca gattttaagg tggatgaaga tggcatggtg 720 tatgccgtga gaagcctcc actctcttct gagcatgcca agttcctgat atatgcccaa 780 gacaaagaga cccaggaaaa gtggcaagtg gcagtaaaat tgagcctgaa gccaacctta 840 actgaggagt cagtgaagga gtcagcagaa gttgaagaaa tagtgttccc aagacaattc 900 agtaagcaca gtggccacct acaaaggcag aagagagact gggtcatccc tccaatcaac 960 ttgccagaaa actccagggg accttttcct caagagcttg tcaggatcag gtctgataga 1020 gataaaaacc tttcactgcg gtacagtgta actgggccag gagctgacca gcctccaact 1080 ggtatcttca ttatcaaccc catctcgggt cagctgtcgg tgacaaagcc cctggatcgc 1140 gagcagatag cccggtttca tttgagggca catgcagtag atattaatgg aaatcaagtg 1200 gagaacccca ttgacattgt catcaatgtt attgacatga atgacaacag acctgagttc 1260 ttacaccagg tttggaatgg gacagttcct gagggatcaa agcctggaac atatgtgatg 1320 accgtaacag caattgatgc tgacgatccc aatgccctca atgggatgtt gaggtacaga 1380 atcgtgtctc aggctccaag caccccttca cccaacatgt ttacaatcaa caatgagact 1440 ggtgacatca tcacagtggc agctggactt gatcgagaaa aagtgcaaca gtatacgtta 1500 ataattcaag ctacagacat ggaaggcaat cccacatatg gcctttcaaa cacagccacg 1560 gccgtcatca cagtgacaga tgtcaatgac aatcctccag agtttactgc catgacgttt 1620 tatggtgaag ttcctgagaa cagggtagac atcatagtag ctaatctaac tgtgaccgat 1680 aaggatcaac cccatacacc agcctggaac gcagtgtaca gaatcagtgg cggagatcct 1740 actggacggt tcgccatcca gaccgaccca aacagcaacg acgggttagt caccgtggtc 1800 aaaccaatcg actttgaaac aaataggatg tttgtcctta ctgttgctgc agaaaatcaa 1860 gtgccattag ccaagggaat tcagcacccg cctcagtcaa ctgcaaccgt gtctgttaca 1920 gttattgacg taaatgaaaa cccttatttt gcccccaatc ctaagatcat tcgccaagaa 1980 gaagggcttc atgccggtac catgttgaca acattcactg ctcaggaccc agatcgatat 2040 atgcagcaaa atattagata cactaaatta tctgatcctg ccaattggct aaaaatagat 2100 cctgtgaatg gacaaataac tacaattgct gttttggacc gagaatcacc aaatgtgaaa 2160 aacaatatat ataatgctac tttccttgct tctgacaatg gaattcctcc tatgagtgga 2220 acaggaacgc tgcagatcta tttacttgat attaatgaca atgcccctca agtgttacct 2280 caagaggcag agacttgcga aactccagac cccaattcaa ttaatattac agcacttgat 2340 tatgacattg atccaaatgc tggaccattt gcttttgatc ttcctttatc tccagtgact 2400 attaagagaa attggaccat cactcggctt aatggtgatt ttgctcagct taatttaaag 2460 ataaaatttc ttgaagctgg tatctatgaa gttcccatca taatcacaga ttcgggtaat 2520 cctcccaaat caaatatttc catcctgcgc gtgaaggttt gccagtgtga ctccaacggg 2580 gactgcacag atgtggacag gattgtgggt gcggggcttg gcaccggtgc catcattgcc 2640 atcctgctct gcatcatcat cctgcttatc cttgtgctga tgtttgtggt atggatgaaa 2700 cgccgggata aagaacgcca ggccaaacaa cttttaattg atccagaaga tgatgtaaga 2760 gataatattt taaaatatga tgaagaaggt ggaggagaag aagaccagga ctatgacttg 2820 agccagctgc agcagcctga cactgtggag cctgatgcca tcaagcctgt gggaatccga 2880 cgaatggatg aaagacccat ccacgccgag ccccagtatc cggtccgatc tgcagcccca 2940 caccctggag acattgggga cttcattaat gagggcctta aagcggctga caatgacccc 3000 acagctccac catatgactc cctgttagtg tttgactatg aaggcagtgg ctccactgct 3060 gggtccttga gctcccttaa ttcctcaagt agtggtggtg agcaggacta tgattacctg 3120 aacgactggg ggccacggtt caagaaactt gctgacatgt atggtggagg tgatgactga 3180 acttcagggt gaacttggtt tttggacaag tacaaacaat ttcaactgat attcccaaaa 3240 agcattcaga agctaggctt taactttgta gtctactagc acagtgcttg ctggaggctt 3300 tggcataggc tgcaaaccaa tttgggctca gagggaatat cagtgatcca tactgtttgg 3360 aaaaacactg agctcagtta cacttgaatt ttacagtaca gaagcactgg gattttatgt 3420 gcctttttgt acctttttca gattggaatt agttttctgt ttaaggcttt aatggtactg 3480 atttctgaaa cgataagtaa aagacaaaat attttgtggt gggagcagta agttaaacca 3540 tgatatgctt caacacgctt ttgttacatt gcatttgctt ttattaaaat acaaaattaa 3600 acaaacaaaa aaactcatgg agcgatttta ttatcttggg ggatgagacc atgagattgg 3660 aaaatgtaca ttacttctag ttttagactt tagtttgttt tttttttttt cactaaaatc 3720 ttaaaactta ctcagctggt tgcaaataaa gggagttttc atatcaccaa tttgtagcaa 3780 aattgaattt tttcataaac tagaatgtta gacacatttt ggtcttaatc catgtacact 3840 tttttatttc tgtatttttc cacttcactg taaaaatagt atgtgtacat aatgttttat 3900 tggcatagtc tatggagaag tgcagaaact tcagaacatg tgtatgtatt atttggacta 3960 tggattcagg ttttttgcat gtttatatct ttcgttatgg ataaagtatt tacaaaacag 4020 tgacatttga ttcaattgtt gagctgtagt tagaatactc aatttttaat ttttttaatt 4080 tttttatttt ttattttctt tttggtttgg ggagggagaa aagttcttag cacaaatgtt 4140 ttacataatt tgtaccaaaa aaaaaaaaaa aggaaaggaa agaaaggggt ggcctgacac 4200 tggtggcact actaagtgtg tgttttttta aaaaaaaaat ggaaaaaaaa aagcttttaa 4260 actggagaga cttctgacaa cagctttgcc tctgtattgt gtaccagaat ataaatgata 4320 cacctctgac cccagcgttc tgaataaaat gctaattttg gatctggaaa aaaaaaaaaa 4380 4380 <210> 29 <211> 1669 <212> DNA <213> Homo sapiens <400> 29 gaggtataag agcctccaag tctgcagctc tcgcccaact cccagacacc tcgcgggctc 60 tgcagcaccg gcaccgtttc caggaggcct ggcggggtgt gcgtccagcc gttgggcgct 120 ttctttttgg acctcggggc catccacacc gtcccctccc cctcccgcct ccctccccgc 180 ctcccccgcg cgccctcccc gcggaggtcc ctcccgtccg tcctcctgct ctctcctccg 240 cgggccgcat cgcccgggcc ggcgccgcgc gcgggggaag ctggcgggct gaggcgcccc 300 gctcttctcc tctgccccgg gcccgcgagg ccacgcgtcg ccgctcgaga gatgatgcag 360 gacgtgtcca gctcgccagt ctcgccggcc gacgacagcc tgagcaacag cgaggaagag 420 ccagaccggc agcagccgcc gagcggcaag cgcgggggac gcaagcggcg cagcagcagg 480 cgcagcgcgg gcggcggcgc ggggcccggc ggagccgcgg gtgggggcgt cggaggcggc 540 gacgagccgg gcagcccggc ccagggcaag cgcggcaaga agtctgcggg ctgtggcggc 600 ggcggcggcg cgggcggcgg cggcggcagc agcagcggcg gcgggagtcc gcagtcttac 660 gaggagctgc agacgcagcg ggtcatggcc aacgtgcggg agcgccagcg cacccagtcg 720 ctgaacgagg cgttcgccgc gctgcggaag atcatcccca cgctgccctc ggacaagctg 780 agcaagattc agaccctcaa gctggcggcc aggtacatcg acttcctcta ccaggtcctc 840 cagagcgacg agctggactc caagatggca agctgcagct atgtggctca cgagcggctc 900 agctacgcct tctcggtctg gaggatggag ggggcctggt ccatgtccgc gtcccactag 960 caggcggagc cccccacccc ctcagcaggg ccggagacct agatgtcatt gtttccagag 1020 aaggagaaaa tggacagtct agagactctg gagctggata actaaaaata aaaatatatg 1080 ccaaagattt tcttggaaat tagaagagca aaatccaaat tcaaagaaac agggcgtggg 1140 gcgcactttt aaaagagaaa gcgagacagg cccgtggaca gtgattccca gacgggcagc 1200 ggcaccatcc tcacacctct gcattctgat agaagtctga acagttgttt gtgttttttt 1260 tttttttttt tttgacgaag aatgttttta tttttatttt tttcatgcat gcattctcaa 1320 gaggtcgtgc caatcagcca ctgaaaggaa aggcatcact atggactttc tctattttaa 1380 aatggtaaca atcagaggaa ctataagaac acctttagaa ataaaaatac tgggatcaaa 1440 ctggcctgca aaaccatagt cagttaattc tttttttcat ccttcctctg aggggaaaaa 1500 caaaaaaaaa cttaaaatac aaaaaacaac attctattta tttattgagg acccatggta 1560 aaatgcaaat agatccggtg tctaaatgca ttcatatttt tatgattgtt ttgtaaatat 1620 ctttgtatat ttttctgcaa taaataaata taaaaaattt agagaaaaa 1669 <210> 30 <211> 2387 <212> DNA <213> Homo sapiens <400> 30 agacacctct gccctcacca tgagcctctg gcagcccctg gtcctggtgc tcctggtgct 60 gggctgctgc tttgctgccc ccagacagcg ccagtccacc cttgtgctct tccctggaga 120 cctgagaacc aatctcaccg acaggcagct ggcagaggaa tacctgtacc gctatggtta 180 cactcgggtg gcagagatgc gtggagagtc gaaatctctg gggcctgcgc tgctgcttct 240 ccagaagcaa ctgtccctgc ccgagaccgg tgagctggat agcgccacgc tgaaggccat 300 gcgaacccca cggtgcgggg tcccagacct gggcagattc caaacctttg agggcgacct 360 caagtggcac caccacaaca tcacctattg gatccaaaac tactcggaag acttgccgcg 420 ggcggtgatt gacgacgcct ttgcccgcgc cttcgcactg tggagcgcgg tgacgccgct 480 caccttcact cgcgtgtaca gccgggacgc agacatcgtc atccagtttg gtgtcgcgga 540 gcacggagac gggtatccct tcgacgggaa ggacgggctc ctggcacacg cctttcctcc 600 tggccccggc attcagggag acgcccattt cgacgatgac gagttgtggt ccctgggcaa 660 gggcgtcgtg gttccaactc ggtttggaaa cgcagatggc gcggcctgcc acttcccctt 720 catcttcgag ggccgctcct actctgcctg caccaccgac ggtcgctccg acggcttgcc 780 ctggtgcagt accacggcca actacgacac cgacgaccgg tttggcttct gccccagcga 840 gagactctac acccaggacg gcaatgctga tgggaaaccc tgccagtttc cattcatctt 900 ccaaggccaa tcctactccg cctgcaccac ggacggtcgc tccgacggct accgctggtg 960 cgccaccacc gccaactacg accgggacaa gctcttcggc ttctgcccga cccgagctga 1020 ctcgacggtg atggggggca actcggcggg ggagctgtgc gtcttcccct tcactttcct 1080 gggtaaggag tactcgacct gtaccagcga gggccgcgga gatgggcgcc tctggtgcgc 1140 taccacctcg aactttgaca gcgacaagaa gtggggcttc tgcccggacc aaggatacag 1200 tttgttcctc gtggcggcgc atgagttcgg ccacgcgctg ggcttagatc attcctcagt 1260 gccggaggcg ctcatgtacc ctatgtaccg cttcactgag gggcccccct tgcataagga 1320 cgacgtgaat ggcatccggc acctctatgg tcctcgccct gaacctgagc cacggcctcc 1380 aaccaccacc acaccgcagc ccacggctcc cccgacggtc tgccccaccg gaccccccac 1440 tgtccacccc tcagagcgcc ccacagctgg ccccacaggt cccccctcag ctggccccac 1500 aggtcccccc actgctggcc cttctacggc cactactgtg cctttgagtc cggtggacga 1560 tgcctgcaac gtgaacatct tcgacgccat cgcggagatt gggaaccagc tgtatttgtt 1620 caaggatggg aagtactggc gattctctga gggcaggggg agccggccgc agggcccctt 1680 ccttatcgcc gacaagtggc ccgcgctgcc ccgcaagctg gactcggtct ttgaggagcg 1740 gctctccaag aagcttttct tcttctctgg gcgccaggtg tgggtgtaca caggcgcgtc 1800 ggtgctgggc ccgaggcgtc tggacaagct gggcctggga gccgacgtgg cccaggtgac 1860 cggggccctc cggagtggca gggggaagat gctgctgttc agcgggcggc gcctctggag 1920 gttcgacgtg aaggcgcaga tggtggatcc ccggagcgcc agcgaggtgg accggatgtt 1980 ccccggggtg cctttggaca cgcacgacgt cttccagtac cgagagaaag cctatttctg 2040 ccaggaccgc ttctactggc gcgtgagttc ccggagtgag ttgaaccagg tggaccaagt 2100 gggctacgtg acctatgaca tcctgcagtg ccctgaggac tagggctccc gtcctgcttt 2160 ggcagtgcca tgtaaatccc cactgggacc aaccctgggg aaggagccag tttgccggat 2220 acaaactggt attctgttct ggaggaaagg gaggagtgga ggtgggctgg gccctctctt 2280 ctcacctttg ttttttgttg gagtgtttct aataaacttg gattctctaa cctttaaaaa 2340 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaa 2387 <210> 31 <211> 3614 <212> DNA <213> Homo sapiens <400> 31 ggcttggggc agccgggtag ctcggaggtc gtggcgctgg gggctagcac cagcgctctg 60 tcgggaggcg cagcggttag gtggaccggt cagcggactc accggccagg gcgctcggtg 120 ctggaatttg atattcattg atccgggttt tatccctctt cttttttctt aaacattttt 180 ttttaaaact gtattgtttc tcgttttaat ttatttttgc ttgccattcc ccacttgaat 240 cgggccgacg gcttggggag attgctctac ttccccaaat cactgtggat tttggaaacc 300 agcagaaaga ggaaagaggt agcaagagct ccagagagaa gtcgaggaag agagagacgg 360 ggtcagagag agcgcgcggg cgtgcgagca gcgaaagcga caggggcaaa gtgagtgacc 420 tgcttttggg ggtgaccgcc ggagcgcggc gtgagccctc ccccttggga tcccgcagct 480 gaccagtcgc gctgacggac agacagacag acaccgcccc cagccccagc taccacctcc 540 tccccggccg gcggcggaca gtggacgcgg cggcgagccg cgggcagggg ccggagcccg 600 cgcccggagg cggggtggag ggggtcgggg ctcgcggcgt cgcactgaaa cttttcgtcc 660 aacttctggg ctgttctcgc ttcggaggag ccgtggtccg cgcgggggaa gccgagccga 720 gcggagccgc gagaagtgct agctcgggcc gggaggagcc gcagccggag gagggggagg 780 aggaagaaga gaaggaagag gagagggggc cgcagtggcg actcggcgct cggaagccgg 840 gctcatggac gggtgaggcg gcggtgtgcg cagacagtgc tccagccgcg cgcgctcccc 900 aggccctggc ccgggcctcg ggccggggag gaagagtagc tcgccgaggc gccgaggaga 960 gcgggccgcc ccacagcccg agccggagag ggagcgcgag ccgcgccggc cccggtcggg 1020 cctccgaaac catgaacttt ctgctgtctt gggtgcattg gagccttgcc ttgctgctct 1080 acctccacca tgccaagtgg tcccaggctg cacccatggc agaaggagga gggcagaatc 1140 atcacgaagt ggtgaagttc atggatgtct atcagcgcag ctactgccat ccaatcgaga 1200 ccctggtgga catcttccag gagtaccctg atgagatcga gtacatcttc aagccatcct 1260 gtgtgcccct gatgcgatgc gggggctgct gcaatgacga gggcctggag tgtgtgccca 1320 ctgaggagtc caacatcacc atgcagatta tgcggatcaa acctcaccaa ggccagcaca 1380 taggagagat gagcttccta cagcacaaca aatgtgaatg cagaccaaag aaagatagag 1440 caagacaaga aaaaaaatca gttcgaggaa agggaaaggg gcaaaaacga aagcgcaaga 1500 aatcccggta taagtcctgg agcgttccct gtgggccttg ctcagagcgg agaaagcatt 1560 tgtttgtaca agatccgcag acgtgtaaat gttcctgcaa aaacacagac tcgcgttgca 1620 aggcgaggca gcttgagtta aacgaacgta cttgcagatg tgacaagccg aggcggtgag 1680 ccgggcagga ggaaggagcc tccctcaggg tttcgggaac cagatctctc accaggaaag 1740 actgatacag aacgatcgat acagaaacca cgctgccgcc accacaccat caccatcgac 1800 agaacagtcc ttaatccaga aacctgaaat gaaggaagag gagactctgc gcagagcact 1860 ttgggtccgg agggcgagac tccggcggaa gcattcccgg gcgggtgacc cagcacggtc 1920 cctcttggaa ttggattcgc cattttattt ttcttgctgc taaatcaccg agcccggaag 1980 attagagagt tttatttctg ggattcctgt agacacaccc acccacatac atacatttat 2040 atatatatat attatatata tataaaaata aatatctcta ttttatatat ataaaatata 2100 tatattcttt ttttaaatta acagtgctaa tgttattggt gtcttcactg gatgtatttg 2160 actgctgtgg acttgagttg ggaggggaat gttcccactc agatcctgac agggaagagg 2220 aggagatgag agactctggc atgatctttt ttttgtccca cttggtgggg ccagggtcct 2280 ctcccctgcc caggaatgtg caaggccagg gcatgggggc aaatatgacc cagttttggg 2340 aacaccgaca aacccagccc tggcgctgag cctctctacc ccaggtcaga cggacagaaa 2400 gacagatcac aggtacaggg atgaggacac cggctctgac caggagtttg gggagcttca 2460 ggacattgct gtgctttggg gattccctcc acatgctgca cgcgcatctc gcccccaggg 2520 gcactgcctg gaagattcag gagcctgggc ggccttcgct tactctcacc tgcttctgag 2580 ttgcccagga gaccactggc agatgtcccg gcgaagagaa gagacacatt gttggaagaa 2640 gcagcccatg acagctcccc ttcctgggac tcgccctcat cctcttcctg ctccccttcc 2700 tggggtgcag cctaaaagga cctatgtcct cacaccattg aaaccactag ttctgtcccc 2760 ccaggagacc tggttgtgtg tgtgtgagtg gttgaccttc ctccatcccc tggtccttcc 2820 cttcccttcc cgaggcacag agagacaggg caggatccac gtgcccattg tggaggcaga 2880 gaaaagagaa agtgttttat atacggtact tatttaatat ccctttttaa ttagaaatta 2940 aaacagttaa tttaattaaa gagtagggtt ttttttcagt attcttggtt aatatttaat 3000 ttcaactatt tatgagatgt atcttttgct ctctcttgct ctcttatttg taccggtttt 3060 tgtatataaa attcatgttt ccaatctctc tctccctgat cggtgacagt cactagctta 3120 tcttgaacag atatttaatt ttgctaacac tcagctctgc cctccccgat cccctggctc 3180 cccagcacac attcctttga aataaggttt caatatacat ctacatacta tatatatatt 3240 tggcaacttg tatttgtgtg tatatatata tatatatgtt tatgtatata tgtgattctg 3300 ataaaataga cattgctatt ctgtttttta tatgtaaaaa caaaacaaga aaaaatagag 3360 aattctacat actaaatctc tctccttttt taattttaat atttgttatc atttatttat 3420 tggtgctact gtttatccgt aataattgtg gggaaaagat attaacatca cgtctttgtc 3480 tctagtgcag tttttcgaga tattccgtag tacatattta tttttaaaca acgacaaaga 3540 aatacagata tatcttaaaa aaaaaaaagc attttgtatt aaagaattta attctgatct 3600 caaaaaaaaa aaaa 3614 <210> 32 <211> 2359 <212> DNA <213> Homo sapiens <400> 32 cgaccgagca cagacacgtt gcccaccgct cctctcccga ggtctgtagt cgcggagaaa 60 cacatgttgc gttactaacg ttcagaggtc tgcgacagct tcgatttgaa tgactagccg 120 ggaacaccaa gtttcactgt gtaattgcgt ccccctactc cggcgcctcc tttgcgacgc 180 tccctggaga aaagcacgcc cactgcacgc gctcagtcgc tacttccgct ctcgagtgtc 240 tccaagcaag atggcggagg agccgcagtc tgtgttgcag cttcctactt caattgctgc 300 tggaggggaa ggacttacgg atgtctcccc agaaacaacc accccggagc ccccgtcttc 360 cgctgcagtt tccccgggaa cagaggaacc tgctggcgac accaagaaaa aaattgacat 420 tttgctaaag gctgtgggag acactcctat tatgaaaaca aagaagtggg cagtagagcg 480 aacacgaacc atccaaggac tcattgactt catcaaaaag tttcttaaac ttgtggcctc 540 agaacagttg tttatttatg tgaatcagtc ctttgctcct tccccagacc aagaagttgg 600 aactctctat gagtgttttg gcagtgatgg taaactggtt ttacattact gcaagtctca 660 ggcgtgggga tgaaccacaa agaaaatcaa cttgctacta catgaaatgg attttcacgg 720 aagagacagc tctgaaaagt tttgatgctt gtggcaagag acttaacaga tgtgatctat 780 ttagtatgtg tctactctat gtttatgcat aagaaaacat ccatagcatg aatggactca 840 gaaaaatgtg atttgtatta atgcaccagt catcataaaa gatggtcatg atagtacacc 900 cattgctcct acttgttact attattgctg cagatctgcc tccaaggttg aaaaggagac 960 taagactgta taaacatctt cattgtcagt tctcaaaatg actgaaattg ttttcatggt 1020 aaaagttaat atactaaagg gttccttttt ttttaatgtt tacatttatc tctatgttta 1080 cctttttagt cacattgacc tgctggctga atacctcaaa tagtccagta gagggcagtc 1140 caccaggcag aaaaggttag gcgttttggt ttcacatctt tgctggggaa taatagggga 1200 aatggctgtt tttgctaatt tttagctaat atctagccag gagagcaagc acataggaca 1260 gactgaaaga ctgtaatttt acacaataca catggcttaa ttattttatt gggatacaga 1320 aaaatataaa ttctggacaa ataagtcata tacctgtttt cagtcctaac atttaaggat 1380 tcttgagtcc caatcacata actgtggtgt tactctgtca tttatatggt gtcaaaagca 1440 cttgatgagt aaacccagta gcatcttttt gagtgtttca taatgcattt tccaacttga 1500 aaacaataat tgaaaaatag ccttattgta tattttatgc catgactaaa agtgccattt 1560 ttactgatgc tattagactg ataatttctt gaagtgaaat ttaacctttt tttctcttta 1620 gtattatgtt tataatgcca tatttttaga aagcattcca gatcaggcat ggtggcttac 1680 acctgtaatc ccagcacttt ggaaggctga ggtgtgggga ttgcgtgaag ccacaagttt 1740 gagaccagcc tggttagcaa ggcaagatcc ccaactctac aaaaaaataa aaattaaaaa 1800 aaaattatta ggctgcagag gcaagaggat cccctgagcc cagaagttca agggtatagt 1860 gagtcgtgat tgtaccactg cattcctgct gagcaacaga gtgagacccc atctcaaaaa 1920 agaaaaaaaa aggcattcta gtaaatcgaa tgtaatgtga atggaatttc aaaacaggat 1980 ctaagatggt atgtagtaga attcaaagta atatcatttt aaagttaaat gagtatggaa 2040 aaggtctgtt ctctagtttt gtccagttca gtttactgaa ggaatatatt taattatatt 2100 catatattta acaaataaaa atatgttgaa ttttcgtatt gtttgccact gagggttcag 2160 atgatagacc tcaaaaaatc gaaaatactg gttgaaattt gtagcatcca tttagttatt 2220 ctttttgacc taaataactt aatagtttat taaatctaag gttagctaaa tatgtagcta 2280 accttatttg ttttctttcc taacaactct gaagaataca taggactttg cacttttttt 2340 tttttttttt ttttttaaa 2359 <210> 33 <211> 2265 <212> DNA <213> Homo sapiens <400> 33 acgcggaggt tgtaattggt ctctagacca cacctagttg ttgagtgccg ctgcttgaaa 60 atctcagttc tgccgagatc gcagaataca cacaagctac ctttgggcac cagagcagac 120 agaaccgcgg agcttcaggg tggaagattc gtggaaactt tgccaaggcc aggacctcgt 180 gtgttcccgt ccgcccctct gggacggcgc cagcccggca ggccgccgac cgtcctgggg 240 ctcccgcgca gcgcgatgcc ggcctcgtcc accgtccacg tgctgcagct gctgcgggag 300 ctgctcgcct tcgtgctcct cagctacacg gtgctcatcg gggcgctgct gctggccggc 360 tggaccactt acttcctggt gctgaagtga cagcgccgtc gccgcgcccg gccccgcctc 420 ccgcccggcc ccgcctcccg cccggccccg cctccctaac tcaccaggaa attcccttca 480 agccctggcc cgaactgagt ccccgcccac ccgccagcgt cacggcgccc gactcagctc 540 cgcgccggac ccacctccgc gccctcaggc cctgcatatg ccccgccccg cgcggaagtt 600 ccggcggttg gttgccttgc gcggccgtta cagcctttgc cctaagcctc gccccctttc 660 cccctgcctg cccaatcccg actgcttcct tgggtggggg cgtggctatg gggcgaggcg 720 ctctcaggtg gaggccgtgc cccgctccgc gctcacgaag ctgcgtcact tccggcgtgt 780 gcgtctggcg tccgcgcgct gcacaatggc ggctctgaag agttggctgt cgcgcagcgt 840 aacttcattc ttcaggtaca gacagtgttt gtgtgttcct gttgtggcta actttaagaa 900 gcggtgtttc tcagaattga taagaccatg gcacaaaact gtgacgattg gctttggagt 960 aaccctgtgt gcggttccta ttgcacagaa atcagagcct cattccctta gtagtgaagc 1020 attgatgagg agagcagtgt ctttggtaac agatagcacc tctacctttc tctctcagac 1080 cacatatgcg ttgattgaag ctattactga atatactaag gctgtttata ccttaacttc 1140 tctttaccga caatatacaa gtttacttgg gaaaatgaat tcagaggagg aagatgaagt 1200 gtggcaggtg atcataggag ccagagctga gatgacttca aaacaccaag agtacttgaa 1260 gctggaaacc acttggatga ctgcagttgg tctttcagag atggcagcag aagctgcata 1320 tcaaactggc gcagatcagg cctctataac cgccaggaat cacattcagc tggtgaaact 1380 gcaggtggaa gaggtgcacc agctctcccg gaaagcagaa accaagctgg cagaagcaca 1440 gatagaagag ctccgtcaga aaacacagga ggaaggggag gagcgggctg agtcggagca 1500 ggaggcctac ctgcgtgagg attgagggcc tgagcacact gccctgtctc cccactcagt 1560 ggggaaagca ggggcagatg ccaccctgcc cagggttggc atgactgtct gtgcaccgag 1620 aagaggcggc agatcctgcc ctggccaatc aggcgagacg cctttgtgag ctgtgagtgc 1680 ctcctgtggt ctcaggcttg cgctggacct ggttcttagc ccttgggcac tgcaccctgt 1740 ttaacatttc accccactct gtacagctgc tcttacccat tttttttacc tcacacccaa 1800 agcattttgc ctacctgggt cagagagagg agtccttttt gtcatgccct taagttcagc 1860 aactgtttaa cctgttttca gtcttattta cgtcgtcaaa aatgatttag tacttgttcc 1920 ctctgttggg atgccagttg tggcaggggg aggggaacct gtccagtttg tacgatttct 1980 ttgtatgtat ttctgatgtg ttctctgatc tgcccccact gtcctgtgag gacagctgag 2040 gccaaggagt gaaaaaccta ttactactaa gagaaggggt gcagagtgtt tacctggtgc 2100 tctcaacagg acttaacatc aacaggactt aacacaggcc tcttgttcct tcctttcttt 2160 ccgtttctct attgtatcca aaggagaaga gtgtaagatt ttgtttgcat ctgaaagaga 2220 aaatgcgtct ctcctggggt cctaaaaaaa aaaaaaaaaa aaaaa 2265 <210> 34 <211> 2722 <212> DNA <213> Homo sapiens <400> 34 ttggcgcgta aaagtggccg ggactttgca ggcagcggcg gccgggggcg gagcgggatc 60 gagccctcgc cgaggcctgc cgccatgggc ccgcgccgcc gccgccgcct gtcacccggg 120 ccgcgcgggc cgtgagcgtc atggccttgg ccggggcccc tgcgggcggc ccatgcgcgc 180 cggcgctgga ggccctgctc ggggccggcg cgctgcggct gctcgactcc tcgcagatcg 240 tcatcatctc cgccgcgcag gacgccagcg ccccgccggc tcccaccggc cccgcggcgc 300 ccgccgccgg cccctgcgac cctgacctgc tgctcttcgc cacaccgcag gcgccccggc 360 ccacacccag tgcgccgcgg cccgcgctcg gccgcccgcc ggtgaagcgg aggctggacc 420 tggaaactga ccatcagtac ctggccgaga gcagtgggcc agctcggggc agaggccgcc 480 atccaggaaa aggtgtgaaa tccccggggg agaagtcacg ctatgagacc tcactgaatc 540 tgaccaccaa gcgcttcctg gagctgctga gccactcggc tgacggtgtc gtcgacctga 600 actgggctgc cgaggtgctg aaggtgcaga agcggcgcat ctatgacatc accaacgtcc 660 ttgagggcat ccagctcatt gccaagaagt ccaagaacca catccagtgg ctgggcagcc 720 acaccacagt gggcgtcggc ggacggcttg aggggttgac ccaggacctc cgacagctgc 780 aggagagcga gcagcagctg gaccacctga tgaatatctg tactacgcag ctgcgcctgc 840 tctccgagga cactgacagc cagcgcctgg cctacgtgac gtgtcaggac cttcgtagca 900 ttgcagaccc tgcagagcag atggttatgg tgatcaaagc ccctcctgag acccagctcc 960 aagccgtgga ctcttcggag aactttcaga tctcccttaa gagcaaacaa ggcccgatcg 1020 atgttttcct gtgccctgag gagaccgtag gtgggatcag ccctgggaag accccatccc 1080 aggaggtcac ttctgaggag gagaacaggg ccactgactc tgccaccata gtgtcaccac 1140 caccatcatc tcccccctca tccctcacca cagatcccag ccagtctcta ctcagcctgg 1200 agcaagaacc gctgttgtcc cggatgggca gcctgcgggc tcccgtggac gaggaccgcc 1260 tgtccccgct ggtggcggcc gactcgctcc tggagcatgt gcgggaggac ttctccggcc 1320 tcctccctga ggagttcatc agcctttccc caccccacga ggccctcgac taccacttcg 1380 gcctcgagga gggcgagggc atcagagacc tcttcgactg tgactttggg gacctcaccc 1440 ccctggattt ctgacagggc ttggagggac cagggtttcc agagatgctc accttgtctc 1500 tgcagccctg gagccccctg tccctggccg tcctcccagc ctgtttggaa acatttaatt 1560 tatacccctc tcctctgtct ccagaagctt ctagctctgg ggtctggcta ccgctaggag 1620 gctgagcaag ccaggaaggg aaggagtctg tgtggtgtgt atgtgcatgc agcctacacc 1680 cacacgtgtg taccgggggt gaatgtgtgt gagcatgtgt gtgtgcatgt accggggaat 1740 gaaggtgaac atacacctct gtgtgtgcac tgcagacacg ccccagtgtg tccacatgtg 1800 tgtgcatgag tccatgtgtg cgcgtggggg ggctctaact gcactttcgg cccttttgct 1860 ctgggggtcc cacaaggccc agggcagtgc ctgctcccag aatctggtgc tctgaccagg 1920 ccaggtgggg aggctttggc tggctgggcg tgtaggacgg tgagagcact tctgtcttaa 1980 aggttttttc tgattgaagc tttaatggag cgttatttat ttatcgaggc ctctttggtg 2040 agcctgggga atcagcaaag gggaggaggg gtgtggggtt gataccccaa ctccctctac 2100 ccttgagcaa gggcaggggt ccctgagctg ttcttctgcc ccatactgaa ggaactgagg 2160 cctgggtgat ttatttattg ggaaagtgag ggagggagac agactgactg acagccatgg 2220 gtggtcagat ggtggggtgg gccctctcca gggggccagt tcagggcccc agctgccccc 2280 caggatggat atgagatggg agaggtgagt gggggacctt cactgatgtg ggcaggaggg 2340 gtggtgaagg cctcccccag cccagaccct gtggtccctc ctgcagtgtc tgaagcgcct 2400 gcctccccac tgctctgccc caccctccaa tctgcacttt gatttgcttc ctaacagctc 2460 tgttccctcc tgctttggtt ttaataaata ttttgatgac gtttgggccg ggttttggga 2520 ctctgttggg aacatttcgg ggcgggagag gccaaggttg ctggggaaat gcccattctc 2580 cacttccctt ctccctgtcc gtgcccgatt tgatttgagc ctcataactc gaagaaaggt 2640 cagcttcctc gctgttttgg tcctaactca aaagcagatc cagtaaaggt ttttgttgta 2700 aaaaaaaaaa aaaaaaaaaa aa 2722 <210> 35 <211> 2560 <212> DNA <213> Homo sapiens <400> 35 tgcggggagc cgagccgccg gcgctcgacg cgcgcgctct cgcgagaccc gcgggatcac 60 gtgacgcccg ggcgcggcgc agctcacgtg acaagcgctg ccggccgcgg tgtcttcttc 120 gtgccggcgt cgcagtggcc gggcctcttg cgtctggtaa cgccgctgtc tctaacgcca 180 gcccttggcg cccgcgcccc gccaccgcag cgcccggcag tccgcggccc aaccgccgcc 240 cgcgcccccg ctccccgcac cgtacccggc cgcctcgcgc catggcggcc cccggcagcg 300 cccggcgacc cctgctgctg ctactgctgt tgctgctgct cggcctcatg cattgtgcgt 360 cagcagcaat gtttatggtg aaaaatggca acgggaccgc gtgcataatg gccaacttct 420 ctgctgcctt ctcagtgaac tacgacacca agagtggccc taagaacatg acctttgacc 480 tgccatcaga tgccacagtg gtgctcaacc gcagctcctg tggaaaagag aacacttctg 540 accccagtct cgtgattgct tttggaagag gacatacact cactctcaat ttcacgagaa 600 atgcaacacg ttacagcgtc cagctcatga gttttgttta taacttgtca gacacacacc 660 ttttccccaa tgcgagctcc aaagaaatca agactgtgga atctataact gacatcaggg 720 cagatataga taaaaaatac agatgtgtta gtggcaccca ggtccacatg aacaacgtga 780 ccgtaacgct ccatgatgcc accatccagg cgtacctttc caacagcagc ttcagcaggg 840 gagagacacg ctgtgaacaa gacaggcctt ccccaaccac agcgccccct gcgccaccca 900 gcccctcgcc ctcacccgtg cccaagagcc cctctgtgga caagtacaac gtgagcggca 960 ccaacgggac ctgcctgctg gccagcatgg ggctgcagct gaacctcacc tatgagagga 1020 aggacaacac gacggtgaca aggcttctca acatcaaccc caacaagacc tcggccagcg 1080 ggagctgcgg cgcccacctg gtgactctgg agctgcacag cgagggcacc accgtcctgc 1140 tcttccagtt cgggatgaat gcaagttcta gccggttttt cctacaagga atccagttga 1200 atacaattct tcctgacgcc agagaccctg cctttaaagc tgccaacggc tccctgcgag 1260 cgctgcaggc cacagtcggc aattcctaca agtgcaacgc ggaggagcac gtccgtgtca 1320 cgaaggcgtt ttcagtcaat atattcaaag tgtgggtcca ggctttcaag gtggaaggtg 1380 gccagtttgg ctctgtggag gagtgtctgc tggacgagaa cagcatgctg atccccatcg 1440 ctgtgggtgg tgccctggcg gggctggtcc tcatcgtcct catcgcctac ctcgtcggca 1500 ggaagaggag tcacgcaggc taccagacta tctagcctgg tgcacgcagg cacagcagct 1560 gcaggggcct ctgttccttt ctctgggctt agggtcctgt cgaaggggag gcacactttc 1620 tggcaaacgt ttctcaaatc tgcttcatcc aatgtgaagt tcatcttgca gcatttacta 1680 tgcacaacag agtaactatc gaaatgacgg tgttaatttt gctaactggg ttaaatattt 1740 tgctaactgg ttaaacatta atatttacca aagtaggatt ttgagggtgg gggtgctctc 1800 tctgaggggg tgggggtgcc gctgtctctg aggggtgggg gtgccgctgt ctctgagggg 1860 tgggggtgcc gctctctctg agggggtggg ggtgccgctt tctctgaggg ggtgggggtg 1920 ccgctctctc tgagggggtg ggggtgctgc tctctccgag gggtggaatg ccgctgtctc 1980 tgaggggtgg gggtgccgct ctaaattggc tccatatcat ttgagtttag ggttctggtg 2040 tttggtttct tcattcttta ctgcactcag atttaagcct tacaaaggga aagcctctgg 2100 ccgtcacacg taggacgcat gaaggtcact cgtggtgagg ctgacatgct cacacattac 2160 aacagtagag agggaaaatc ctaagacaga ggaactccag agatgagtgt ctggagcgct 2220 tcagttcagc tttaaaggcc aggacgggcc acacgtggct ggcggcctcg ttccagtggc 2280 ggcacgtcct tgggcgtctc taatgtctgc agctcaaggg ctggcacttt tttaaatata 2340 aaaatgggtg ttatttttat ttttttttgt aaagtgattt ttggtcttct gttgacattc 2400 ggggtgatcc tgttctgcgc tgtgtacaat gtgagatcgg tgcgttctcc tgatgttttg 2460 ccgtggcttg gggattgtac acgggaccag ctcacgtaat gcattgcctg taacaatgta 2520 ataaaaagcc tctttctttt aaaaaaaaaa aaaaaaaaaa 2560 <210> 36 <211> 1030 <212> DNA <213> Homo sapiens <400> 36 accgggcgag ttacctcccg cagccgcagc cgccgtgctc agcgcgagcc ccggagccct 60 tgagcgcgag gcgcggagcc cccggagccc ccaaaccgca gacacatccc cgcgccccag 120 agccccggcc tgcgcgccca gccgggcccg cgcgatgccc tcagaccggc ctttcaagca 180 gcggcggagc ttcgccgacc gctgtaagga ggtacagcag atccgcgacc agcaccccag 240 caaaatcccg gtgatcatcg agcgctacaa gggtgagaag cagctgcccg tcctggacaa 300 gaccaagttt ttggtcccgg accatgtcaa catgagcgag ttggtcaaga tcatccggcg 360 ccgcctgcag ctgaacccca cgcaggcctt cttcctgctg gtgaaccagc acagcatggt 420 gagtgtgtcc acgcccatcg cggacatcta cgagcaggag aaagacgagg acggcttcct 480 ctatatggtc tacgcctccc aggaaacctt cggcttctga gccagcagta ggggggctcg 540 gcctgggagt cggggggccc cggtcaggcc ctgcccagag agctcctggt tcctgaactg 600 agctgcctct accgtggtgg gctgggcagg catgtgcccc cctagtcaga gggcaccaac 660 ccacctactc tgcccctggg tggatcctgg gccggtcgtg ttagggttgt ccctctgggt 720 gctggctggt gggatggggg agggtgggga gcagctccca gcacccctgc tgtgtggttc 780 atcttttttt taggcccctg cctgtctgcc catctgcccc tcacccaccc gaggctctgc 840 ccaccgcctg gacctgccca cccctgaaag actggcccct ggctccccgc ccctcggtct 900 ccacgtggtg tatggatctg tggtcattgt ccctctgcag aataaagatt gctcaggcct 960 gcctggcaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1020 aaaaaaaaaa 1030 <210> 37 <211> 5059 <212> DNA <213> Homo sapiens <400> 37 ctttgcgcac gcgcgccgct tcccagtggc aagcgcgggc aggaccgcgt tgcgtcatcg 60 gggcgcgcgc ctcagagaga gctgtggttg ccggaagttg agcggcggca agaaataatg 120 gcggcagcta cgggggatcc tggactctct aaactgcagt ttgccccttt tagtagtgcc 180 ttggatgttg ggttttggca tgagttgacc cagaagaagc tgaacgagta tcggctggat 240 gaagctccca aggacattaa gggttattac tacaatggtg actctgctgg gctgccagct 300 cgcttaacat tggagttcag tgcttttgac atgagtgctc ccaccccagc ccgttgctgc 360 ccagctattg gaacactgta taacaccaac acactcgagt ctttcaagac tgcagataag 420 aagctccttt tggaacaagc agcaaatgag atatgggaat ccataaaatc aggcactgct 480 cttgaaaacc ctgtactcct caacaagttc ctcctcttga catttgcaga tctaaagaag 540 taccacttct actattggtt ttgctatcct gccctctgtc ttccagagag tttacctctc 600 attcaggggc cagtgggttt ggatcaaagg ttttcactaa aacagattga agcactagag 660 tgtgcatatg ataatctttg tcaaacagaa ggagtcacag ctcttcctta cttcttaatc 720 aagtatgatg agaacatggt gctggtttcc ttgcttaaac actacagtga tttcttccaa 780 ggtcaaagga cgaagataac aattggtgta tatgatccct gtaacttagc ccagtaccct 840 ggatggcctt tgaggaattt tttggtccta gcagcccaca gatggagtag cagtttccag 900 tctgttgaag ttgtttgctt ccgtgaccgt accatgcagg gggcgagaga cgttgcccac 960 agcatcatct tcgaagtgaa gcttccagaa atggcattta gcccagattg tcctaaagca 1020 gttggatggg aaaagaacca gaaaggaggc atgggaccaa ggatggtgaa cctcagtgaa 1080 tgtatggacc ctaaaaggtt agctgagtca tcagtggatc taaatctcaa actgatgtgt 1140 tggagattgg ttcctacttt agacttggac aaggttgtgt ctgtcaaatg tctgctgctt 1200 ggagccggca ccttgggttg caatgtagct aggacgttga tgggttgggg cgtgagacac 1260 atcacatttg tggacaatgc caagatctcc tactccaatc ctgtgaggca gcctctctat 1320 gagtttgaag attgcctagg gggtggtaag cccaaggctc tggcagcagc ggaccggctc 1380 cagaaaatat tccccggtgt gaatgccaga ggattcaaca tgagcatacc tatgcctggg 1440 catccagtga acttctccag tgtcactctg gagcaagccc gcagagatgt ggagcaactg 1500 gagcagctca tcgaaagcca tgatgtcgtc ttcctattga tggacaccag ggagagccgg 1560 tggcttcctg ccgtcattgc tgcaagcaag agaaagctgg tcatcaatgc tgctttggga 1620 tttgacacat ttgttgtcat gagacatggt ctgaagaaac caaagcagca aggagctggg 1680 gacttgtgtc caaaccaccc tgtggcatct gctgacctcc tgggctcatc gctttttgcc 1740 aacatccctg gttacaagct tggctgctac ttctgcaatg atgtggtggc cccaggagat 1800 tcaaccagag accggacctt ggaccagcag tgcactgtga gtcgtccagg actggccgtg 1860 attgcaggag ccctggccgt ggaattgatg gtatctgttt tgcagcatcc agaagggggc 1920 tatgccattg ccagcagcag tgacgatcgg atgaatgagc ctccaacctc tcttgggctt 1980 gtgcctcacc agatccgggg atttctttca cggtttgata atgtccttcc cgtcagcctg 2040 gcatttgaca aatgtacagc ttgttcttcc aaagttcttg atcaatatga acgagaagga 2100 tttaacttcc tagccaaggt gtttaattct tcacattcct tcttagaaga cttgactggt 2160 cttacattgc tgcatcaaga aacccaagct gctgagatct gggacatgag cgatgatgag 2220 accatctgag atggccccgc tgtggggctg acttctcccc ggccgcctgc tgaggagctc 2280 tccatcgcca gagcaggact gctgacccca ggcctggtga ttctgggccc ctcctccata 2340 ccccgaggtc tgggattccc ccctctgctg cccaggagtg gccagtgttc ggcgttgctc 2400 gggattcaag ataccaccag ttcagagcta aataataacc ttggccttgg ccttgctatt 2460 gacctgggac ttggtcctcc atgcagtttt tatttcttgt cacagtgact gatagccatc 2520 ccccaggatc ctttcccctt ggccctgagg gggtgaccca acacagacca aatggggaaa 2580 tgagcaacca gctcctgccc agagccactg cgggaggtgg caccctcatc cccggaatgt 2640 gctgcccacc gcaccgcagg ctcctcctgt gggggccctg ggcatgggtg agggtgggac 2700 cccgtgagcg cactgcaccc tggccctggt ggagcgggag gaggaggaga gccgagctgg 2760 gtacgagact aaagggccca catgacccag tgacgccaga tttccaccaa ggactgagtg 2820 agctgctcag acatggcttt ctgcctccca gcctgtcctc cactgtgggc atagcatctg 2880 tgcctgcctg cctgcttgag ggagaggagt ttctgctgct gccttgagct ggggggaaga 2940 gcccaggggc agatcctggc agctgcctgg atggggctcc tccctgccct tatgagcagg 3000 ccaggcccag aaaggccgag cctgggctgc cttcctgccc cagccgaggg aggggtcaga 3060 cggctctacc atgggtaact caggcaagag ctggttttcc tctttattct gggtgtgtgc 3120 agctgtgagg ccccaaccca ggagaggcca tggcctaggt acctgtgacc accctgcccc 3180 cgtgtagagg gcatcgtctt tcctgctatt ttattctttc agcttttgtc ttaggcccag 3240 aatcaaagtg aaaattgagt cgagctgacc cttacaacag taggatttag tagggtagat 3300 ttcaaatgag gcttcgcttc tcccaaagta gccagtccaa gttccagtgg ctgtcgttca 3360 gctcatggga gcttcatggg gacacagccg gcacaggtgc agggcccgag tccgcccacc 3420 cagcctggcg ctgaaactgc acacgtacac tatgtggttt aagagcactt tattattgtt 3480 cttaaggcta cttttaagta caaaaaaaga tggcctgcca aacctttttt tttcttcttc 3540 caggaaaaac aggccacaga gaatggtata ttacagattt acacacatga agagaaggtc 3600 agagcgcact gcaggcagcg cggctctggg aagaacttca cggagcccct tcttagagca 3660 gggagggggc tttctcagtg aaatgtttgg ttttctgctg cctcctctgc cccaggcccc 3720 cctccagggt actgcctatc ccagataggt cagtgcacca gggacccggc cgccagcacc 3780 gccgacccct cccagagtga cgcccttgtt cactgacaaa gagacctgtc ccaggagtgt 3840 cctccaccga gccggtcagc tgtgggtggt tttcctgtta cgacgctcag tagcctgtag 3900 caataacaaa ctcgtggcta tgaatgcaga tgcagtgttc tcatagaata actgttcctg 3960 cacttttaca gacaaatcta cgacaaaaaa aaagatcaac tttttttttc cgaacaacaa 4020 aaaaaatgaa tgattacaat aggaaaggga aaaattaaat agctacatat cattaacaaa 4080 ttaatgttct tcaaaaaata cctacaaatt tctctgtaca ttctttacgc acagcgtaac 4140 gatggtctca aaatcaccca tatagaaaag tgttctcaac gatttttcct acagaaaata 4200 taggggcctg aatgccaaag cttggaagcc cagtacagtg ggagtgaaat gtgtgcgggg 4260 caaggagaag ggcttttctt tcctccactt ttcaaaggcc tgcagccact ctgtgactac 4320 aagagccagt cctccgacct tttcacccag tgccaatttc caaaattcaa cagctaaaaa 4380 ctgtaaaacc gggggtcata cggtgtgcag agtccacaaa gccttgcagg tgaggtgacc 4440 acgcccacgt cacctggtca ggtgccatcg tcgtgagcct ctggtgggcc aggtgggaca 4500 cagcacaccc cagggggagg ggatagaaac gctcattgac caaaaaggag cagctgtgac 4560 ctccacagct gtgtctgtca tgcttgcttc atctaatttc tagttagtag ctattaatat 4620 agcaaataat aaatgcagta ataacagtat aaagtcagag gaatgtatac tgccttggcc 4680 ccagcgtacg aggaagcgta taaaacacca tatcacagat tgtctgtcag taatctgctg 4740 ttcagccaag agagttcaaa gggagcagtt tctgcatgta gggaagttgg aagacacaaa 4800 ccccacctcc cctgggagct tgtaacaaag cagacaggga tgcaaaaata aatgatgtca 4860 gcctgcagcc aaactccagc atcccacacc gcagctgacc cactgctcat cgcgagggcc 4920 tgccaggagc tggcctcccg cactacttgt gagtaaagtg aatatcaaat accaatctta 4980 gagtacaact gtaccagcag taagtatatc taggactgta actgacaaaa ataaactaat 5040 tctgaaaaga aaaaaaaaa 5059 <210> 38 <211> 2117 <212> DNA <213> Homo sapiens <400> 38 gacttaacgc gcccccgccc cgcgcccggc ctcggcagcc gcctgtcgcc gcgggagcag 60 ccgctatctc tgtgtgtccg cgtgtgcgcc cggtccccgc ctgccgcacc atggagagct 120 accacaagcc tgaccagcag aagctgcagg ccttgaagga cacggccaac cgcctacgta 180 tcagctccat ccaggccacc actgcggcgg gctctggcca ccccacgtca tgctgcagcg 240 ccgcagagat catggctgtc ctctttttcc acaccatgcg ctacaagtcc caggaccccc 300 ggaatccgca caatgaccgc tttgtgctct ccaagggcca tgcagctccc atcctctacg 360 cggtctgggc tgaagctggt ttcctggccg aggcggagct gctgaacctg aggaagatca 420 gctccgactt ggacgggcac ccggtcccga aacaagcttt caccgacgtg gccactggct 480 ccctgggcca gggcctcggg gccgcttgtg ggatggccta caccggcaaa tacttcgaca 540 aggccagcta ccgagtctat tgcttgctgg gagacgggga gctgtcagag ggctctgtat 600 gggaggccat ggccttcgcc agcatctata agctggacaa ccttgtggcc attctagaca 660 tcaatcgcct gggccagagt gacccggccc cactgcagca ccagatggac atctaccaga 720 agcggtgcga ggccttcggt tggcatgcca tcatcgtgga tggacacagc gtggaggagc 780 tgtgcaaggc ctttggccag gccaagcacc agccaacagc catcattgcc aagaccttca 840 agggccgagg gatcacgggg gtagaagata aggagtcttg gcatgggaag cccctcccca 900 aaaacatggc tgagcagatc atccaggaga tctacagcca gatccagagc aaaaagaaga 960 tcctggcaac ccctccacag gaggacgcac cctcagtgga cattgccaac atccgcatgc 1020 ccagcctgcc cagctacaaa gttggggaca agatagccac ccgcaaggcc tacgggcagg 1080 cactggccaa gctgggccat gccagtgacc gcatcatcgc cctggatggg gacaccaaaa 1140 attccacctt ctcggagatc ttcaaaaagg agcacccgga ccgcttcatc gagtgctaca 1200 ttgctgagca gaacatggtg agcatcgcgg tgggctgtgc cacccgcaac aggacggtgc 1260 ccttctgcag cacttttgca gccttcttca cgcgggcctt tgaccagatt cgcatggccg 1320 ccatctccga gagcaacatc aacctctgcg gctcccactg cggcgtttcc atcggggaag 1380 acgggccctc ccagatggcc ctagaagatc tggctatgtt tcggtcagtc cccacatcaa 1440 ctgtctttta cccaagtgat ggcgttgcta cagagaaggc agtggaacta gccgccaata 1500 caaagggtat ctgcttcatc cggaccagcc gcccagaaaa tgccatcatc tataacaaca 1560 atgaggactt ccaggtcgga caagccaagg tggtcctgaa gagcaaggat gaccaggtga 1620 ccgttatcgg ggctggggtg accctgcacg aggccttggc cgctgccgaa ctgctgaaga 1680 aagaaaagat caacatccgc gtgctggacc ccttcaccat caagcccctg gacagaaaac 1740 tcattctcga cagcgctcgt gccaccaagg gcaggatcct caccgtggag gaccattatt 1800 atgaaggtgg cattggtgag gctgtgtcca gtgcagtagt gggcgagcct ggcatcactg 1860 tcacccacct ggcagttaac cgggtaccaa gaagtgggaa gccggctgag ctgctgaaga 1920 tgtttggtat cgacagggat gccattgcac aagctgtgag gggcctcatc accaaggcct 1980 agggcgggta tgaagtgtgg ggcgggggtc tatacattcc tgagattctg ggaaaggtgc 2040 tcaaagatgt actgagagga ggggtaaata tatgttttga gaaaaatgaa ttggccctga 2100 aaaaaaaaaa aaaaaaa 2117 <210> 39 <211> 2215 <212> DNA <213> Homo sapiens <400> 39 ttccccggct ctagcaggcc ggcttctctg tccaatgccc acccggagct gggaggagga 60 gtctgcgtaa tgtgcgtgtg aagagactgg gggagctggc cggggctcac ggtgtttgac 120 ccgtcggtcg tgcgtgagag gaaagggaag gaggaggtcc cgaatagcgg tcgccgaaat 180 gttccggtgt ggaggcctgg cggcgggtgc tttgaagcag aagctggtgc ccttggtgcg 240 gaccgtgtgc gtccgaagcc cgaggcagag gaaccggctc ccaggcaact tgttccagcg 300 atggcatgtt cctctagaac tccagatgac aagacaaatg gctagctctg gtgcatcagg 360 gggcaaaatc gataattctg tgttagtcct tattgtgggc ttatcaacag taggagctgg 420 tgcctatgcc tacaagacta tgaaagagga tgaaaaaaga tacaatgaaa gaatttcagg 480 gttagggctg acaccagaac agaaacagaa aaaggccgcg ttatctgctt cagaaggaga 540 ggaagttcct caagacaagg cgccaagtca tgttcctttc ctgctaattg gtggaggcac 600 agctgctttt gctgcagcca gatccatccg ggctcgggat cctggggcca gggtactgat 660 tgtatctgaa gatcctgagc tgccgtacat gcgacctcct ctttcaaaag aactgtggtt 720 ttcagatgac ccaaatgtca caaagacact gcgattcaaa cagtggaatg gaaaagagag 780 aagcatatat ttccagccac cttctttcta tgtctctgct caggacctgc ctcatattga 840 gaatggtggt gtggctgtcc tcactgggaa gaaggtagta cagctggatg tgagagacaa 900 catggtgaaa cttaatgatg gctctcaaat aacctatgaa aagtgcttga ttgcaacagg 960 aggtactcca agaagtctgt ctgccattga tagggctgga gcagaggtga agagtagaac 1020 aacgcttttc agaaagattg gagactttag aagcttggag aagatttcac gggaagtcaa 1080 atcaattacg attatcggtg ggggcttcct tggtagcgaa ctggcctgtg ctcttggcag 1140 aaaggctcga gccttgggca cagaagtgat tcaactcttc cccgagaaag gaaatatggg 1200 aaagatcctc cccgaatacc tcagcaactg gaccatggaa aaagtcagac gagagggggt 1260 taaggtgatg cccaatgcta ttgtgcaatc cgttggagtc agcagtggca agttacttat 1320 caagctgaaa gacggcagga aggtagaaac tgaccacata gtggcagctg tgggcctgga 1380 gcccaatgtt gagttggcca agactggtgg cctggaaata gactcagatt ttggtggctt 1440 ccgggtaaat gcagagctac aagcacgctc taacatctgg gtggcaggag atgctgcatg 1500 cttctacgat ataaagttgg gaaggaggcg ggtagagcac catgatcacg ctgttgtgag 1560 tggaagattg gctggagaaa atatgactgg agctgctaag ccgtactggc atcagtcaat 1620 gttctggagt gatttgggcc ccgatgttgg ctatgaagct attggtcttg tggacagtag 1680 tttgcccaca gttggtgttt ttgcaaaagc aactgcacaa gacaacccca aatctgccac 1740 agagcagtca ggaactggta tccgatcaga gagtgagaca gagtccgagg cctcagaaat 1800 tactattcct cccagcaccc cggcagttcc acaggctccc gtccaggggg aggactacgg 1860 caaaggtgtc atcttctacc tcagggacaa agtggtcgtg gggattgtgc tatggaacat 1920 ctttaaccga atgccaatag caaggaagat cattaaggac ggtgagcagc atgaagatct 1980 caatgaagta gccaaactat tcaacattca tgaagactga agccccacag tggaattggc 2040 aaacccactg cagcccctga gaggaggtcg aatgggtaaa ggagcatttt tttattcagc 2100 agactttctc tgtgtatgag tgtgaatgat caagtccttt gtgaatattt tcaactatgt 2160 aggtaaattc ttaatgttca catagtgaaa taaattctga ttcttctaaa ttaaa 2215 <210> 40 <211> 1535 <212> DNA <213> Homo sapiens <400> 40 cctccgctca gtccgggagc gcacgtgggc cgcggcgctc cgacctccgc tttcccaccg 60 cccgcagctg aagcacatcc cgcagcccgg cgcggactcc gatcgccgca gttgccctct 120 ggcgccatgt cgcagaacgg agcgcccggg atgcaggagg agagcctgca gggctcctgg 180 gtagaactgc acttcagcaa taatgggaac gggggcagcg ttccagcctc ggtttctatt 240 tataatggag acatggaaaa aatactgctg gacgcacagc atgagtctgg acggagtagc 300 tccaagagct ctcactgtga cagcccacct cgctcgcaga caccacaaga taccaacagg 360 gcttctgaaa cagataccca tagcattgga gagaaaaaca gctcacagtc tgaggaagat 420 gatattgaaa gaaggaaaga agttgaaagc atcttgaaga aaaactcaga ttggatatgg 480 gattggtcaa gtcggccgga aaatattccc cccaaggagt tcctctttaa acacccgaag 540 cgcacggcca ccctcagcat gaggaacacg agcgtcatga agaaaggggg catattctct 600 gcagaatttc tgaaagtttt ccttccatct ctgctgctct ctcatttgct ggccatcgga 660 ttggggatct atattggaag gcgtctgaca acctccacca gcaccttttg atgaagaact 720 ggagtctgac ttggttcgtt agtggattac ttctgagctt gcaacatagc tcactgaaga 780 gctgttagat cctggggtgg ccacgtcact tgtgtttatt tgttctgtaa atgctgcgtt 840 cctaatttag taaaataaaa gaatagacac taaaatcatg ttgatctata attacaccta 900 tgggatcaat aagcatgtca gactgattaa tgtctactgt gaaaatttgg tagtaaattt 960 tcatttgata ttagatataa atatctgaat ataaataatt ttaatatact agtcatgatg 1020 tgtgttgtat tttaaaaatt atctgcaacc ttaattcagc tgaagtactt tatatttcaa 1080 aagaatgaat aacattgata ataaaatcgc tactttaagg ggtttgtcca aaataaatat 1140 tgtggcctta tatatcacac tattgtagaa agtattattt aatttaaatg gatgcaggtt 1200 gtctactaaa gaaagattat atataactat gctaattgtt cataatcaac agaaaccaag 1260 atagagctac aaactcagct gtacagttcg tacactaaac tcttcttgct tttgcattat 1320 aaggaattaa gtctccgatt attaggtgat caccctggat gatcagtttt ctgctgaagg 1380 cacctactca gtatcttttc ctctttatca ctctgcattg gtgaatttaa tcctctcctt 1440 tgtgttcaac ttttgtgtgc ttttaaaatc agctttattc taagcaaatc tgtgtctact 1500 ttaaaaaact ggaaatggaa aaaaaaataa atctt 1535 <210> 41 <211> 1372 <212> DNA <213> Homo sapiens <400> 41 cgggtgctga tgcgagtcgg tggcagcgag gacattttct gactccctgg cccctgacac 60 ggctgcactt tccatcccgt cgcggggccg gccgctactc cggccccagg atgcagaatg 120 tgattaatac tgtgaaggga aaggcactgg aagtggctga gtacctgacc ccggtcctca 180 aggaatcaaa gtttaaggaa acaggtgtaa ttaccccaga agagtttgtg gcagctggag 240 atcacctagt ccaccactgt ccaacatggc aatgggctac aggggaagaa ttgaaagtga 300 aggcatacct accaacaggc aaacaatttt tggtaaccaa aaatgtgccg tgctataagc 360 ggtgcaaaca gatggaatat tcagatgaat tggaagctat cattgaagaa gatgatggtg 420 atggcggatg ggtagataca tatcacaaca caggtattac aggaataacg gaagccgtta 480 aagagatcac actggaaaat aaggacaata taaggcttca agattgctca gcactatgtg 540 aagaggaaga agatgaagat gaaggagaag ctgcagatat ggaagaatat gaagagagtg 600 gattgttgga aacagatgag gctaccctag atacaaggaa aatagtagaa gcttgtaaag 660 ccaaaactga tgctggcggt gaagatgcta ttttgcaaac cagaacttat gacctttaca 720 tcacttatga taaatattac cagactccac gattatggtt gtttggctat gatgagcaac 780 ggcagccttt aacagttgag cacatgtatg aagacatcag tcaggatcat gtgaagaaaa 840 cagtgaccat tgaaaatcac cctcatctgc caccacctcc catgtgttca gttcacccat 900 gcaggcatgc tgaggtgatg aagaaaatca ttgagactgt tgcagaagga gggggagaac 960 ttggagttca tatgtatctt cttattttct tgaaatttgt acaagctgtc attccaacaa 1020 tagaatatga ctacacaaga cacttcacaa tgtaatgaag agagcataaa atctatccta 1080 attattggtt ctgattttta aagaattaac ccatagatgt gaccattgac catattcatc 1140 aatatataca gtttctctaa taagggactt atatgtttat gcattaaata aaaatatgtt 1200 ccactaccag ccttacttgt ttaataaaaa tcagtgcaaa gaaaaaaaaa aaaaaaaaaa 1260 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 1320 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa 1372 <210> 42 <211> 3553 <212> DNA <213> Homo sapiens <400> 42 gagccagcgc ggtagggcca gagtgggaag gccagagcgg gcgtccccgc cagtgacccc 60 acgccgcccg tccgcgccca acccggcctc cgccgagtgt ccaaaccaaa agcgaaagga 120 acccgacccc gcgtcccctc cggcggctcc gtagtcgcgt ccgcttggag ctcgccgggc 180 gcctccgacc ctgccgggcc gctttgtgac ttcactcgtt tcgcaacaag cccgggcagc 240 ccgcgcccca cccactctgg cccggcagcc tcgccgcccg cagcctcgct ccgctcctcg 300 cgcttcccct ccctccgggg ctgggcctgc cccggccgtc gcggagcctc ccctcccacc 360 gtccgtgagt gtacgcgccc ggccgccgcc tccaggcagc ccggagcaac ccggcgcccg 420 gccccgctgg gcgcagcact ccgtcggcgg cggcggcggc gcgatgctgt gcttcctgag 480 gggaatggct ttcgtcccct tcctcttggt gacctggtcg tcagccgcct tcattatctc 540 ctacgtggtc gccgtgctct ccgggcacgt caaccccttc ctcccgtata tcagtgatac 600 gggaacaaca cctccagaga gtggtatttt tggatttatg ataaacttct ctgcatttct 660 tggtgcagcc acgatgtata caagatacaa aatagtacag aagcaaaatc aaacctgcta 720 tttcagcact cctgttttta acttggtgtc tttagtgctt ggattggtgg gatgtttcgg 780 aatgggcatt gtcgccaatt ttcaggagtt agctgtgcca gtggttcatg acgggggcgc 840 tcttttggcc tttgtctgtg gtgtcgtgta cacgctccta cagtccatca tctcttacaa 900 atcatgtccc cagtggaaca gtctctcgac atgccacata cggatggtca tctctgccgt 960 ttcttgcgca gctgtcatcc ccatgattgt ctgtgcttca ctaatttcca taaccaagct 1020 ggagtggaat ccaagagaaa aggattatgt atatcacgta gtgagtgcga tctgtgaatg 1080 gacagtggcc tttggtttta ttttctactt cctaactttc atccaagatt tccagagtgt 1140 caccctaagg atatccacag aaatcaatgg tgatatttga agaaagaaga attcagtctc 1200 actcagtgaa tgtcgcaggc catttctaaa agtgctacag aggacagaca gggttttgag 1260 gccaccctga ttattgggat gcatctgcag cacatccagg acttgaattt cattacgagt 1320 tcctaatagt tgtatttcta aagatgtgtt tcctagagaa tgtacagcct tatgacactg 1380 tagtgatgtt tttataattt tctaagtaga tttttttata ttaacaaatt catatacaga 1440 aaaaataagg tgttacaaaa aatggagagc tcttattttt gtacagattc tgtcgttttt 1500 gttttatttg tgtgagattt atggaaatac actaaatgag taattcaggt tcagtacatt 1560 tattacaaag tgaaatcagg ggatattcat ttgtaaattt tattcttagt gaatgaactg 1620 tataattttt tttatcagga gagcacttat aaaattcaat ttataaagat catataccca 1680 aatcataaag atttagttga tacattaaca ctaagatact ctgattttta gccgaactaa 1740 acaaagtgct tctactgaga ggcctttata ccaccatgta cagtaactct aagtgaatac 1800 ggaagacctt ggttttgaaa ttctgccacc ttgtttctcc ctgctcatga ggtcgcacct 1860 tttgctcttg ctgctaattg cccattcgta gtgggtgtaa tgccaggtgg aatggtttca 1920 acaagtcagg tgaaaaccat cctttattgt tgctggcaca acttgatata tagtctgact 1980 cagaactgaa gctcacatct caaattcatt tcatgccagt aaatgtggca aagagaagaa 2040 aggcccaaga gcgagacaag aagaatggag aagggggcag ccaagaagaa cttctgggtt 2100 cagggtactg tttatttgct ccttctcttc atgcctgtgg ctggatgtcc cacaacacta 2160 taagaaatat aagtcaagcc ctttgtgtta agcaagaact acagactcca tcttttcacc 2220 caaatcatga atgaccaata aaaagcaagt tattccagag gaagaagcag cccttgaaat 2280 gttaaggctt aggcttgaaa ggtgaagagc aggaattctc tctttcaaat cctagagcat 2340 aaacccatgt gtggccaagt gagatcagcc ctcaagggca catgccaagg gcagagcagc 2400 ccatgtagac agcttcggag ggcatggggg tgtagggagt tcggggtagc tcctcattaa 2460 ctatttgttg ggtgagtaaa ggggtgaggc tcagtggcag gtacctctgc aatgacaagc 2520 tgcctcccct ctatgtgttt agcatatgtt attagaacat gtccgacacc cctaccgctg 2580 ccatttgggc cctttaataa agccaagtag agaaatctgg caataaaagg caaatgtaag 2640 catgctttct ttaagacgca tcataaatgg ttttctttaa gtgaatggaa gagtttgaca 2700 gagatacacc tttgtaagaa aacattaaga atgctggctg gctgtggtgg ctcacacctg 2760 tattcccagc actttgggag gcctaggcag gaggattgct tgagcctggg acttcgagac 2820 cagactggga aacatggcaa aatcccatct ctacaacaaa aatacaaaaa ttagccaagt 2880 gcggtggtgt gcctgtagtc ctagttactt gggaggctga ggtgggagaa tcacctgagc 2940 ccaggaggtg gaggctgcag tgagccatgc caatgcactc cagtctgggc aacagagtga 3000 gaccctgtct caaaaataaa taaataaata aatgaataaa gagaatgcta atcatttctg 3060 ggttcactgc gactcactgt agtgctgggg atcccccttg taacactgga actgaaagac 3120 agtgatgaaa gctatgtcaa gcattcatta ttctgaagag gaggagaaat gccacatacc 3180 tttcccatgg gacctgtggt ggaatgaatc catacttctg cctcacttcg agcagacttt 3240 tgttctcggc gctcctcacg atggagtttc atgcttcatt ttcacatctc tctgcacaat 3300 tagattggga gctccttgag ggcagagtac gtgccttaat ctttatcttt gtaatgccac 3360 aatgaacaga gtgcctcctg gtacactgta ggagcttaag aaatactcac tgaatgcatg 3420 aatgaatgaa tgaacaaatg aaggaatgac taaggatgtt tgtagtgcta taatatagaa 3480 tgggatttac tctgctttac cagttagttt cataataaac aaatagtctg tatcgcctgg 3540 taaaaaaaaa aaa 3553 <210> 43 <211> 3244 <212> DNA <213> Homo sapiens <400> 43 gtgacgtcat ctccgggcgc cgagggtgac tggacttgtg gtgcgctgcc agggctccgc 60 agcgttgccg gttgtattcg ctggatacca gagggcggaa gtgcagcagg gttcagctcc 120 gacctccgcg ccggtgcttt ttgcggctgc gcgggcttcc tggagtcctg ctaccgcgtc 180 cccgcaggac agtgtgtcag gcgggcagct tgccccgccg ccccaccgga gcgcggaatc 240 tgggcgtccc caccagtgcg gggagccgga aggaggagcc atagcttgga gtaggtttgg 300 ctttggttga aataagaatt tagcctgtat gtactgcttt aactcctgga agaatgacag 360 atgacaaaga tgtgcttcga gatgtgtggt ttggacgaat tccaacttgt ttcacgctat 420 atcaggatga gataactgaa agggaagcag aaccatacta tttgcttttg ccaagagtaa 480 gttatttgac gttggtaact gacaaagtga aaaagcactt tcagaaggtt atgagacaag 540 aagacattag tgagatatgg tttgaatatg aaggcacacc actgaaatgg cattatccaa 600 ttggtttgct atttgatctt cttgcatcaa gttcagctct tccttggaac atcacagtac 660 attttaagag ttttccagaa aaagaccttc tgcactgtcc atctaaggat gcaattgaag 720 ctcattttat gtcatgtatg aaagaagctg atgctttaaa acataaaagt caagtaatca 780 atgaaatgca gaaaaaagat cacaagcaac tctggatggg attgcaaaat gacagatttg 840 accagttttg ggccatcaat cggaaactca tggaatatcc tgcagaagaa aatggatttc 900 gttatatccc ctttagaata tatcagacaa cgactgaaag acctttcatt cagaagctgt 960 ttcgtcctgt ggctgcagat ggacagttgc acacactagg agatctcctc aaagaagttt 1020 gtccttctgc tattgatcct gaagatgggg aaaaaaagaa tcaagtgatg attcatggaa 1080 ttgagccaat gttggaaaca cctctgcagt ggctgagtga acatctgagc tacccggata 1140 attttcttca tattagtatc atcccacagc caacagattg aaggatcaac tatttgcctg 1200 aacagaatca tccttaaatg ggatttatca gagcatgtca cccttttgct tcaatcaggt 1260 ttggtggagg caacctgacc agaaacactt cgctgctgca agccagacag gaaaaagatt 1320 ccatgtcaga taaggcaact gggctggtct tactttgcat cacctctgct ttcctccact 1380 gccatcatta aacctcagct gtgacatgaa agacttaccg gaccactgaa ggtcttctgt 1440 aaaatataat gaagctgaaa cctttggcct aagaagaaaa tggaagtatg tgccactcga 1500 tttgtatttc tgattaacaa ataaacaggg gtatttccta aggtgaccat ggttgaactt 1560 tagctcatga aagtggaaac attggtttaa ttttcaagag aattaagaaa gtaaaagaga 1620 aattctgtta tcaataactt gcaagtaatt ttttgtaaaa gattgaatta cagtaaaccc 1680 atctttcctt aacgaaaatt tcctatgttt acagtctgtc tattggtatg caatcttgta 1740 actttgataa tgaacagtga gagattttta aataaagcct ctaaatatgt tttgtcattt 1800 aataacatac agttttgtca cttttcaagt actttctgac tcacatacag tagatcactt 1860 tttactctgt gttaccattt tgactggtcg tcattggcat ggggtggata tagggcatag 1920 gattacttgt ctcagaagct gtcatagaat ttcttgctgc caattaaaaa acctgtgttc 1980 tttacacact acacgtataa atattgtaac tgttcatctt tgttgtttta tcactgtaag 2040 cctgtcaaat catagtatcc taagcatctg taaatgctaa ttttgcattt ttggaaaaac 2100 ccattccttc caagctagtg tttttcattg gctccaggtc taatttttca ctgtggtccc 2160 tggcagccag tcttttgaag tttaaagatt acctgtctct tgactgcagt accttttctt 2220 taatttttac caaaaatatc cagaggttac tggagttctt attcaatata aggaaagttt 2280 gctgcacttt attaccaagc ctctgggatt ttaccagtca aacatatttg tgcattacat 2340 ttcatttctt gtgagctagc tggctgtcca tattgaatgt tgacccattt gagtacgcta 2400 aaaggcttac agtatcagac acgatcatgg ttttagatcc cataataaaa atgaatgttt 2460 ttcttataaa aaattataca aatgctgaag tgagattcta ctattgttca ttgcttcctt 2520 ttctttttcc ttttgcgatt ttcactgatt aatagcacat ttcttcacaa aattagataa 2580 agttggtcaa agaccagata ttctggaatg gaaattgtaa agcttaatca aaaagaatag 2640 ccagtacagc atacaatctc agaaacttag aagcaagtag aaaataattg gttgatgtaa 2700 acgaaagtgc cattttagta aaggcaggaa aaaaatagca atatttgagt tatgtaagga 2760 taaaaaatcc actgacttgt atttttgcac aagaggctgg tctgaatatg attgttcaca 2820 ttaagagtgt ttattcgtcg gttcattttg gggattttcc cccttgatgt tttgacagat 2880 tgaagtgagc tttagtgagc aaaaggatca gaatgcaggg aacactaagc tgtgatgaag 2940 aaagtgtggt aaaaagccag agtagtttta tacagacaaa accagtgtca ggcctttgca 3000 gtaggcttga gtgaacttct gatctagatt tgaaagtaaa ttttatgaag acattgccca 3060 tttttacttc ctcattcatt attgtaccag catcatagct ttattactct aatcccaggt 3120 aagtcaagcc tacaatgccc tagaggaaga gtaaaaccag aaattcatgc tggcttaaat 3180 aatctatttt tgtttctttt catttgaata tttaaatttt atggtttatt aaaaaattaa 3240 ataa 3244 <210> 44 <211> 1579 <212> DNA <213> Homo sapiens <400> 44 gaggaggtgc ttgccagaca ctgggtcatg gcagtggtcg gtgaagctgc agttgcctag 60 ggcagggatg gagagagagt ctgggcatga ggagagggtc tcgggatgtt tggctggact 120 agattttaca gaaagcctta tccaggcttt taaaattact ctttccagac ttcatctgag 180 actccttctt cagccaacat tccttagccc tgaatacatt tcctatcctc atctttccct 240 tctttttttt cctttctttt acatgtttaa atttaaacca ttcttcgtga ccccttttct 300 tgggagattc atggcaagaa cgagaagaat gatggtgctt gttaggggat gtcctgtctc 360 tctgaacttt ggggtcctat gcattaaata attttcctga cgagctcaag tgctccctct 420 ggtctacaat ccctggcggc tggccttcat cccttgggca agcattgcat acagctcatg 480 gccctccctc taccataccc tccacccccg ttcgcctaag ctcccttctc cgggaatttc 540 atcatttcct agaacagcca gaacatttgt ggtctatttc tctgttagtg tttaaccaac 600 catctgttct aaaagaaggg ctgaactgat ggaaggaatg ctgttagcct gagactcagg 660 aagacaactt ctgcagggtc actccctggc ttctggagga aagagaagga gggcagtgct 720 ccagtggtac agaagtgaga cataatggaa tcaggcttca cctccaagga cacctatcta 780 agccatttta accctcggga ttacctagaa aaatattaca agtttggttc taggcactct 840 gcagaaagcc agattcttaa gcaccttctg aaaaatcttt tcaagatatt ctgcctagac 900 ggtgtgaagg gagacctgct gattgacatc ggctctggcc ccactatcta tcagctcctc 960 tctgcttgtg aatcctttaa ggagatcgtc gtcactgact actcagacca gaacctgcag 1020 gagctggaga agtggctgaa gaaagagcca gaggcctttg actggtcccc agtggtgacc 1080 tatgtgtgtg atcttgaagg gaacagagtc aagggtccag agaaggagga gaagttgaga 1140 caggcggtca agcaggtgct gaagtgtgat gtgactcaga gccagccact gggggccgtc 1200 cccttacccc cggctgactg cgtgctcagc acactgtgtc tggatgccgc ctgcccagac 1260 ctccccacct actgcagggc gctcaggaac ctcggcagcc tactgaagcc agggggcttc 1320 ctggtgatca tggatgcgct caagagcagc tactacatga ttggtgagca gaagttctcc 1380 agcctccccc tgggccggga ggcagtagag gctgctgtga aagaggctgg ctacacaatc 1440 gaatggtttg aggtgatctc gcaaagttat tcttccacca tggccaacaa cgaaggactt 1500 ttctccctgg tggcgaggaa gctgagcaga cccctgtgat gcctgtgacc tcaattaaag 1560 caattccttt gacctgtca 1579 <210> 45 <211> 5085 <212> DNA <213> Homo sapiens <400> 45 agcgccatgc gcagactcag ttcctggaga aagatggcga cagccgagaa gcagaaacac 60 gacgggcggg tgaagatcgg ccactacatt ctgggtgaca cgctgggggt cggcaccttc 120 ggcaaagtga aggttggcaa acatgaattg actgggcata aagtagctgt gaagatactc 180 aatcgacaga agattcggag ccttgatgtg gtaggaaaaa tccgcagaga aattcagaac 240 ctcaagcttt tcaggcatcc tcatataatt aaactgtacc aggtcatcag tacaccatct 300 gatattttca tggtgatgga atatgtctca ggaggagagc tatttgatta tatctgtaag 360 aatggaaggc tggatgaaaa agaaagtcgg cgtctgttcc aacagatcct ttctggtgtg 420 gattattgtc acaggcatat ggtggtccat agagatttga aacctgaaaa tgtcctgctt 480 gatgcacaca tgaatgcaaa gatagctgat tttggtcttt caaacatgat gtcagatggt 540 gaatttttaa gaacaagttg tggctcaccc aactatgctg caccagaagt aatttcagga 600 agattgtatg caggcccaga ggtagatata tggagcagtg gggttattct ctatgcttta 660 ttatgtggaa cccttccatt tgatgatgac catgtgccaa ctctttttaa gaagatatgt 720 gatgggatct tctatacccc tcaatattta aatccttctg tgattagcct tttgaaacat 780 atgctgcagg tggatcccat gaagagggcc acaatcaaag atatcaggga acatgaatgg 840 tttaaacagg accttccaaa atatctcttt cctgaggatc catcatatag ttcaaccatg 900 attgatgatg aagccttaaa agaagtatgt gaaaagtttg agtgctcaga agaggaagtt 960 ctcagctgtc tttacaacag aaatcaccag gatcctttgg cagttgccta ccatctcata 1020 atagataaca ggagaataat gaatgaagcc aaagatttct atttggcgac aagcccacct 1080 gattcttttc ttgatgatca tcacctgact cggccccatc ctgaaagagt accattcttg 1140 gttgctgaaa caccaagggc acgccatacc cttgatgaat taaatccaca gaaatccaaa 1200 caccaaggtg taaggaaagc aaaatggcat ttaggaatta gaagtcaaag tcgaccaaat 1260 gatattatgg cagaagtatg tagagcaatc aaacaattgg attatgaatg gaaggttgta 1320 aacccatatt atttgcgtgt acgaaggaag aatcctgtga caagcactta ctccaaaatg 1380 agtctacagt tataccaagt ggatagtaga acttatctac tggatttccg tagtattgat 1440 gatgaaatta cagaagccaa atcagggact gctactccac agagatcggg atcagttagc 1500 aactatcgat cttgccaaag gagtgattca gatgctgagg ctcaaggaaa atcctcagaa 1560 gtttctctta cctcatctgt gacctcactt gactcttctc ctgttgacct aactccaaga 1620 cctggaagtc acacaataga attttttgag atgtgtgcaa atctaattaa aattcttgca 1680 caataaacag aaaactttgc ttatttcttt tgcagcaata agcatgcata ataagtcaca 1740 gccaaatgct tccatttgta atcaagttat acataattat aaccgagggc tggcgttttg 1800 gaatgcaatt tgcacaggga ttggaacatg atttatagtt aaaagcctaa tatgcagaaa 1860 tgaattaaga tcattttgtt gttcattgtg cagtatgtat atagcataat atacacagtg 1920 aattataggt ctcaggctta cttgattttt ggctatttta tatttagtgt acacagggct 1980 ttgaaatatt aatttacata aaggccttca tatattatta cgtgttatat attacgtgtt 2040 ataaatttat tcaataaata tttgcctaga attcccaaga cctttatagg tgattttgtt 2100 ttctgggctc cttaacttca taaatagcta gtatcttcca gcagtagtaa cagtctggat 2160 aacttcttcc atatccctcc ctctttgttt ttttgagaca gtgtcacttt gtcacccagg 2220 ctggagtgca atggtgtggt ctcggctcac tgcaacctcc acctcccggg ttcaagtgat 2280 tctcccgcct cagcttcctg agtagctgga actacaggcg tgtgccacca cacccggcta 2340 atttttcgta tttttagtgt agacggggtt tcactatgtt gcccaggctg gtctcgaact 2400 cctgaccgcg tgatccacca cctcagcttc ccaaagtggt gggattacag gcgtgagcca 2460 ccgcacccgg cctccatatc ccccttttaa aattctgtag tgtatggtaa gtcatatcag 2520 atatcagacc taatttaaat ttcattttag ctttacaagt ccaaaaacac agaatttata 2580 tattcagata ctctagcact aattttagtc ttaaaatatt cccacgatat tctgtacaca 2640 aaatgttctt tttgttacaa gagctgagtt gcatatactg tagataaatc atattatttt 2700 tgccaatttc acaaattcct ctggcccatc atgtcagtca ttattgagta tatgcacaca 2760 ttgctactta tttgattatg tatcttttaa attgattcag tgcatagaaa actatctctt 2820 acaaacttta agtgctctga tatgacttcc cccccaaatt ttattatgaa catttttaaa 2880 aacagaaaaa ttgaaaaact gtttggtaag cacatgtata tctaccattt agattcagca 2940 gttgttaatg ttttgtcatt tgttttctct atacctatat atgtatagat acagctagtt 3000 atgcatatat atgcatatat gtgtttgttt gtgtatgtat atatgctttt ttccccctga 3060 accatttgga tgttacagac atacttatca ccgtgaaaat acttcaagta tctcctacag 3120 ataatgacat tctcctaaaa atccgtaata ccattgtaaa agtaataatt ccccaatatc 3180 atctaatcaa gccatattta aatttctgaa gttaactcca aatttcttta tagctgatta 3240 tttcaaacta ggatccaatt aaagtttaca tatgacactt ggttataact ctttagttgg 3300 atataacatt attattattt tgataaaata tggaacaaat caattctatt aataagtggt 3360 cacatttgtt ttgggcttaa attacttttt aaagatactg gattttccta agatttctga 3420 tttacactga tatttttttt tgtcattctt aattgcatca cacaatagat gtaaatgaag 3480 atgtagtcac ctcagataaa attggtatcg tgtatgataa tattgtatca tttatatttg 3540 ccttatgtta actttaagaa attgattttt ttgtattaat cattttccca ttgcaacaga 3600 gctatatttt ttctatttta agaatcatat tttaggatta tttttggcaa atacagtgag 3660 cacttatgta accagatgat aatgaactca aatgtcatga tagcttgcat aaatggtgac 3720 tctagtagat ttgactcaag cacttctaga atcatgcact gaattcaaaa gaaaaatctt 3780 gctgcttttt gtccagggct tgttctattc aacttctaat ttgaaagctg tacaaagtaa 3840 tagaagttcc atttaaatat gagttcaaaa ctgtatttac tttttatgtg gccctctctt 3900 taggggattc taattttact tagggtctct aagtgcagca taatgttcct gatgttaaca 3960 gaagactgta tttttaaagt tacaaatttg tatatggaat taagtaatgg cgctatatac 4020 gctgttgtgg ggagggggga agaaaaggag gaaccaatta aataggacct tttaaaaatt 4080 gttaattttg taaactttgc ttctcttata agttattgtg attcatttta gttactgtgt 4140 tttattttga aaatatttaa atattgcact tctataaata gtatgataaa tgcacagaca 4200 attgcagtaa attctttttt aagctaggat atttgaaatg acaacctttg gttaagtgtg 4260 tcaaggttgc aacagaattt tcacaatttt tttgttgttt gcaaattgtt actaatattg 4320 aagaggtaag ggaggcaatg caaatgattt ttaatctttt tttattatct tttcagcagt 4380 ttatattttt tgtgacttta tgcaaccata tttttacttt gtcttgacaa ctgaaagatg 4440 tataaggttt tttgccagaa atgtactgta tacatagttt taagtataac agattttact 4500 gatatgtaaa aattttgcca ttaaaataaa tgatttctca ctgagaggaa cttttctacc 4560 aggttggggc atatgggagc ttaatatatc atatctaatt taaaataatt tcactgaaat 4620 aaactccatt gcttttacct aatttttttc ttgagatgct tttgtagttt ttcagagttt 4680 tagatgattt tatacaaaat cctctgccta gcactgctct ttttgatgtt gtagtgacac 4740 catttacatt gaattaatgc ttggtagcct ggggctagat gtggaactcc atggatctgt 4800 gttctgactg gcacctttgg aatgaaagaa aagtgtgtgc tgtccaaatt ttttcccctt 4860 aattctttcc ctcatcttct cacccataat agaaatttta tttccattgt gagttctgac 4920 aagaatgaaa ttccacatac aacataactg taaattgttg gtaggtagaa gttaatattt 4980 gtggttcatg tatattttga ccagagtata tttaagtata taatttcagc ttccttgatt 5040 tagaaatatg atataataaa gaaaaactcc atttatcatc tgtta 5085 <210> 46 <211> 2914 <212> DNA <213> Homo sapiens <400> 46 gtgctctgag tttttggttt ctgtttcacc ttgtgtctga gctggtctga aggctggttg 60 ttcagactga gcttcctgcc tgcctgtacc ccgccaacag cttcagaaga aggtgactgg 120 tggctgcctg aggaatacca gtgggcaaga gaattagcat ttctggagca tctgctgtct 180 gagcagcccc tgggtgcgtc cactttctgg gcacgtgagg ttgggccttg gccgcctgag 240 cccttgagtt ggtcacttga accttgggaa tattgagatt atattctcct gccttttaaa 300 aagatggact tcagcagaaa tctttatgat attggggaac aactggacag tgaagatctg 360 gcctccctca agttcctgag cctggactac attccgcaaa ggaagcaaga acccatcaag 420 gatgccttga tgttattcca gagactccag gaaaagagaa tgttggagga aagcaatctg 480 tccttcctga aggagctgct cttccgaatt aatagactgg atttgctgat tacctaccta 540 aacactagaa aggaggagat ggaaagggaa cttcagacac caggcagggc tcaaatttct 600 gcctacaggt tccacttctg ccgcatgagc tgggctgaag caaacagcca gtgccagaca 660 cagtctgtac ctttctggcg gagggtcgat catctattaa taagggtcat gctctatcag 720 atttcagaag aagtgagcag atcagaattg aggtctttta agtttctttt gcaagaggaa 780 atctccaaat gcaaactgga tgatgacatg aacctgctgg atattttcat agagatggag 840 aagagggtca tcctgggaga aggaaagttg gacatcctga aaagagtctg tgcccaaatc 900 aacaagagcc tgctgaagat aatcaacgac tatgaagaat tcagcaaagg ggaggagttg 960 tgtggggtaa tgacaatctc ggactctcca agagaacagg atagtgaatc acagactttg 1020 gacaaagttt accaaatgaa aagcaaacct cggggatact gtctgatcat caacaatcac 1080 aattttgcaa aagcacggga gaaagtgccc aaacttcaca gcattaggga caggaatgga 1140 acacacttgg atgcaggggc tttgaccacg acctttgaag agcttcattt tgagatcaag 1200 ccccacgatg actgcacagt agagcaaatc tatgagattt tgaaaatcta ccaactcatg 1260 gaccacagta acatggactg cttcatctgc tgtatcctct cccatggaga caagggcatc 1320 atctatggca ctgatggaca ggaggccccc atctatgagc tgacatctca gttcactggt 1380 ttgaagtgcc cttcccttgc tggaaaaccc aaagtgtttt ttattcaggc ttgtcagggg 1440 gataactacc agaaaggtat acctgttgag actgattcag aggagcaacc ctatttagaa 1500 atggatttat catcacctca aacgagatat atcccggatg aggctgactt tctgctgggg 1560 atggccactg tgaataactg tgtttcctac cgaaaccctg cagagggaac ctggtacatc 1620 cagtcacttt gccagagcct gagagagcga tgtcctcgag gcgatgatat tctcaccatc 1680 ctgactgaag tgaactatga agtaagcaac aaggatgaca agaaaaacat ggggaaacag 1740 atgcctcagc ctactttcac actaagaaaa aaacttgtct tcccttctga ttgatggtgc 1800 tattttgttt gttttgtttt gttttgtttt tttgagacag aatctcgctc tgtcgcccag 1860 gctggagtgc agtggcgtga tctcggctca ccgcaagctc cgcctcccgg gttcaggcca 1920 ttctcctgcc tcagcctccc gagtagctgg gactacaggg gcccgccacc acacctggct 1980 aattttttaa aaatattttt agtagagaca gggtttcact gtgttagcca gggtggtctt 2040 gatctcctga cctcgtgatc cacccacctc ggcctcccaa agtgctggga ttacaggcgt 2100 gagccaccgc gcctggccga tggtactatt tagatataac actatgttta tttactaatt 2160 ttctagattt tctactttat taattgtttt gcactttttt ataagagcta aagttaaata 2220 ggatattaac aacaataaca ctgtctcctt tctcttatgc ttaaggcttt gggaatgttt 2280 ttagctggtg gcaataaata ccagacacgt acaaaatcca gctatgaata tagagggctt 2340 atgattcaga ttgttatcta tcaactataa gcccactgtt aatattctat taactttaat 2400 tctctttcaa agctaaattc cacactacca cattaaaaaa attagaaagt agccacgtat 2460 ggtggctcat gtctataatc ccagcacttt gggaggttga ggtgggagga ttgcttgaac 2520 ccaagaggtc aaggctgcag tgagccatgt tcacaccgct gcactcaagc ttgggtgaca 2580 gaacaagacc ccgtctcaaa aaaaattttt tttttaataa aacaaaattt gtttgaaatc 2640 ttttaaaaat tcaaatgatt tttacaagtt ttaaataagc tctccccaaa cttgctttat 2700 gccttcttat tgcttttatg atatatatat gcttggctaa ctatatttgc tttttgctaa 2760 caatgctctg gggtcttttt atgcatttgc atttgctctt tcatctctgc ttggattatt 2820 ttaaatcatt aggaattaag ttatctttaa aatttaagta tcttttttca aaaacatttt 2880 ttaatagaat aaaatataat ttgatcttat taaa 2914 <210> 47 <211> 5239 <212> DNA <213> Homo sapiens <400> 47 ggatccggat tcggattagc agcccgggaa gagtgccgtg gcacaggcgc cggagggagc 60 gcgaccctcg gaccccgcct ggcccgcggg gctgggaccc ggccccggcc tgcccgatgg 120 ggcgcgcggc cccggagatg cgccctcgcc cggccccgcg cccccggccc cgcgcccccg 180 gcccgcccgc cccggcccgc gcctccgcct gagtcccccg cgccttggcc cgccaccccc 240 cgccccgcgc ccccggcccg cctgcgccat ggagcccggc cgcggcggca cagagaccgt 300 gggcaagttc gagttctccc gcaaggacct gatcggccac ggcgccttcg cggtggtctt 360 caagggccgc caccgcgaga agcacgattt ggaggtcgcc gtcaagtgca ttaacaagaa 420 gaacctcgcc aagtctcaga cgctgctggg gaaggaaatc aaaatcctga aggaactgaa 480 acatgaaaac atcgtggccc tgtacgactt ccaggaaatg gctaattctg tctacctggt 540 tatggagtac tgcaacggtg gggacctggc cgactacctg cacgccatgc gcacgctgag 600 cgaggacacc atcaggctct tcctgcagca gatcgcgggc gccatgcggc ttctgcacag 660 caaaggcatc atccaccgcg acctgaaacc gcagaacatc ctgctgtcca accccgccgg 720 ccgccgcgcc aaccccaaca gcatccgcgt caagatcgct gacttcggct tcgcgcggta 780 cctccagagc aacatgatgg cggccacact ctgcggctcc cccatgtaca tggcccccga 840 ggtcatcatg tcccagcact acgacgggaa ggcggacctg tggagcatcg gcaccatcgt 900 ctaccagtgc ctgacgggga aggcgccctt ccaggccagc agcccccagg acctgcgcct 960 gttctacgag aagaacaaga cgttggtccc caccatcccc cgggagacct cggccccgct 1020 gcggcagctg ctcctggccc tactgcaacg caaccacaag gaccgcatgg acttcgatga 1080 gttttttcat caccctttcc tcgatgccag cccctcggtc aggaaatccc cacccgtgcc 1140 tgtgccctcg tacccaagct cggggtccgg cagcagctcc agcagcagct ccacctccca 1200 cctggcctcc ccgccgtccc tgggcgagat gcagcagctg cagaagaccc tggcctcccc 1260 ggctgacacc gctggcttcc tgcacagctc ccgggactct ggtggcagca aggactcttc 1320 ctgtgacaca gacgacttcg tcatggtccc cgcgcagttt ccaggtgacc tggtggctga 1380 ggcgcccagt gccaaacccc cgccagacag cctgatgtgc agtgggagct cactggtggc 1440 ctctgcgggc ttggagagcc acggccggac cccatctcca tccccaccct gcagcagctc 1500 ccccagtccc tcaggccggg ctggcccgtt ctccagcagc aggtgcggcg cctctgtccc 1560 catcccagtc cccacgcagg tgcagaacta ccagcgcatt gagcgaaacc tgcagtcacc 1620 cacccagttc caaacacctc ggtcctctgc catccgcagg tcaggcagca ccagccccct 1680 gggctttgca agggccagcc cctcgccccc tgcccacgct gagcatggag gcgtcctggc 1740 caggaagatg tctctgggtg gaggccggcc ctacacgcca tctcctcaag ttggaaccat 1800 ccctgagcgg ccaggctgga gcgggacgcc ctccccacag ggagctgaga tgcggggtgg 1860 caggtcccct cgtccaggct cctctgcacc cgagcactct ccccgcactt ccgggctggg 1920 ctgccgcctg cacagcgccc ccaacctgtc tgacttgcac gtcgtccgcc ccaagctgcc 1980 caaacccccc acggaccccc tgggagctgt gttcagccca ccacaggcca gccctcccca 2040 gccgtcccac ggcctgcagt cctgccggaa cctgcggggc tcacccaagc tgcccgactt 2100 cctgcagcga aaccccctgc cccccatcct gggctccccc accaaggctg tgccctcctt 2160 tgacttcccg aagaccccca gctcccagaa cctgctggcc ctcctagccc ggcagggcgt 2220 ggtgatgacg ccccctcgaa accggacgct gcccgacctc tcggaggtgg gacccttcca 2280 tggtcagccg ttgggccctg gcctgcggcc aggcgaggac cccaagggcc cctttggccg 2340 gtctttcagc accagccgcc tcactgacct gctccttaag gcggcgtttg ggacacaagc 2400 cccggacccg ggcagcacgg agagcctgca ggagaagccc atggagatcg caccctcagc 2460 tggctttgga gggagcctgc acccaggagc ccgtgctggg ggcaccagca gcccttcccc 2520 ggtggtcttc accgtgggct ctcccccgag cgggagcacg cccccccagg gcccccgcac 2580 caggatgttc tcagcgggcc ccactggctc tgccagctct tctgcccgcc acctggtgcc 2640 tgggccctgc agcgaggccc cagcccctga gctccctgct ccaggacacg gctgcagctt 2700 tgccgacccc attgctgcga acctggaggg ggctgtgacc ttcgaggccc ccgacctccc 2760 tgaggagacc ctcatggagc aagagcacac ggagatcctg cgtggcctgc gcttcacgct 2820 gctgttcgtg cagcacgtcc tggagatcgc agccctgaag ggcagcgcca gtgaggcggc 2880 ggggggccct gagtaccagc tgcaggagag tgtggtggcc gaccagatca gcctgctgag 2940 ccgagaatgg ggcttcgcgg aacagctggt gctgtacctg aaggtggccg agctactgtc 3000 ctccggcctg caaagtgcca tcgaccagat ccgggccggc aagctctgcc tgtcgtccac 3060 tgtgaagcag gtggtgcgca ggctgaatga gctgtacaag gccagcgtgg tgtcctgcca 3120 gggcctgagc ctgcggctgc agcgcttctt cctggacaag cagcggctcc tggaccgcat 3180 tcacagcatc actgccgaga ggctcatctt cagccacgct gtgcagatgg tgcagtcggc 3240 tgccctggac gagatgttcc agcaccgtga gggctgcgtc ccacgctacc acaaggccct 3300 gctgctcctg gaggggctgc agcacatgct ctcggaccag gccgacatcg agaacgtcac 3360 caagtgcaag ctgtgcattg agcggagact ctcggcgctg ctgactggca tctgtgcctg 3420 acctttctgg cctggctggg ccccccgtcc tgccgagccc tgcagagtgg gctctgtgtg 3480 ctggctggac tcctcgggac aagcccatgg cgctgatcgc tggtgctgag ccctgccctg 3540 ggccccacgg acagtcagcc tgccggcctc cctgcagctc acggggcaga accagcacat 3600 ctggagccac acagcttggg gggtgtctcc catcttttac aggtggggat cacagaattt 3660 ctgcccctcc agctgcctgg ctcagcaggc gtgggtgcca ccaccctcta gccccagggc 3720 agccccggag gacaggcaag ggcctgagac cactgccgac tcaaagccaa agcgagctcc 3780 tgcttagggc aggtcagcag gcactgtgcc caggaagagc ctgcggcctc ggcgtccccc 3840 agtctccagg agcctctccc tccgagatac ccacccagct ttgtcaatca cccaagcact 3900 ttatgcatat agagacagaa cctggacctc accagggact gctgggcagc gattcctggc 3960 agtggcctgg tgtttgtaca tacacatatg cagacacatg ccagggcccc ccaagcccga 4020 gcaccggacc acgttgctgc ccaggtctgg acctcagcgg gagaactggc tccgggggga 4080 gtggggccct gcgctagagg cagaggcagt tctttgttca agcgttcctc tggggaccgg 4140 cagcagaggc accgtgttct ctcagccctg gatacgtctt gtaatctttc acactttatt 4200 cctaaaacgt gtcttatttt tatgcagctc attttttctt taaaggagaa aacttgtagg 4260 tgtttaagaa ttggttttgg gagggcgagg actgggccag gttagaggca gatggcacag 4320 gggcgtgtgg cgggcgggtg aggctgcttt gcacacctgt gttggtggct gtcccctgcc 4380 gcccctccct gtggcagcag caggacaggt gtgtgcccag caccctccct acctgggcct 4440 ggaagcagat gaggggaata cttcatgcaa agaaaaaagt aacatgtgca aaagctcccc 4500 gtccagcttt gacagtcagt tttgatgtca gctcctcggc agggtaggcc tgatgacagc 4560 cctgtccctc cctgcctctg ccttgcccaa ggccacggag ggcatctgca gagaggcctg 4620 ccttccggat tccaggcggg catgccctgc aaaccccgcc tgggcctccc ttggtctgcc 4680 cagccctcgg ttagccctgc ctgaatcagt agatacttga acgagtcccc agtctgcggg 4740 aggcagtggt ggggccatgg acccatgcgg ggggttccag ggtcacacgc cacataacag 4800 acaaaaatac acacacgtgt gtttttcttt gcaatacttg aaatattgcc actgtgcttg 4860 gacttagaag aagaaaatcc ccgtgacttc ttcctcatca ccttgatggc tttattctca 4920 ccttgtgggg catgtttgta tttattgctt catggccgac tggaatcctg agtcctggga 4980 agctggcact gcggggatct tgcccggtgt cctggtcctc ttgcttccgt cgcggccgca 5040 tgtgcgtgtg tccaagcagg tcctgggcgc ctcaactgct gcccctggtt gaatgttctc 5100 ttgatagtgc tggacccttt gtctatttta aagcgaattt tgtgtgattt cctgcccttt 5160 gcgttatatt gtataatacc aacgtaagga aataaacctt tggaattgtt gggctggtgt 5220 caaaaaaaaa aaaaaaaaa 5239 <210> 48 <211> 2386 <212> DNA <213> Homo sapiens <400> 48 ggaggaggaa gcaagcgagg gggctggttc ctgagcttcg caattcctgt gtcgccttct 60 gggctcccag cctgccgggt cgcatgatcc ctccggccgg agctggtttt tttgccagcc 120 accgcgaggc cggctgagtt accggcatcc ccgcagccac ctcctctccc gacctgtgat 180 acaaaagatc ttccgggggc tgcacctgcc tgcctttgcc taaggcggat ttgaatctct 240 ttctctccct tcagaatctt atcttggctt tggatcttag aagagaatca ctaaccagag 300 acgagactca gtgagtgagc aggtgttttg gacaatggac tggttgagcc catccctatt 360 ataaaaatgt ctcagagcaa ccgggagctg gtggttgact ttctctccta caagcctcc 420 cagaaaggat acagctggag tcagtttagt gatgtggaag agaacaggac tgaggcccca 480 gaagggactg aatcggagat ggagaccccc agtgccatca atggcaaccc atcctggcac 540 ctggcagaca gccccgcggt gaatggagcc actggccaca gcagcagttt ggatgcccgg 600 gaggtgatcc ccatggcagc agtaaagcaa gcgctgaggg aggcaggcga cgagtttgaa 660 ctgcggtacc ggcgggcatt cagtgacctg acatcccagc tccacatcac cccagggaca 720 gcatatcaga gctttgaaca ggatactttt gtggaactct atgggaacaa tgcagcagcc 780 gagagccgaa agggccagga acgcttcaac cgctggttcc tgacgggcat gactgtggcc 840 ggcgtggttc tgctgggctc actcttcagt cggaaatgac cagacactga ccatccactc 900 taccctccca cccccttctc tgctccacca catcctccgt ccagccgcca ttgccaccag 960 gagaaccact acatgcagcc catgcccacc tgcccatcac agggttgggc ccagatctgg 1020 tcccttgcag ctagttttct agaatttatc acacttctgt gagaccccca cacctcagtt 1080 cccttggcct cagaattcac aaaatttcca caaaatctgt ccaaaggagg ctggcaggta 1140 tggaagggtt tgtggctggg ggcaggaggg ccctacctga ttggtgcaac ccttacccct 1200 tagcctccct gaaaatgttt ttctgccagg gagcttgaaa gttttcagaa cctcttcccc 1260 agaaaggaga ctagattgcc tttgttttga tgtttgtggc ctcagaattg atcattttcc 1320 ccccactctc cccacactaa cctgggttcc ctttccttcc atccctaccc cctaagagcc 1380 atttaggggc cacttttgac tagggattca ggctgcttgg gataaagatg caaggaccag 1440 gactccctcc tcacctctgg actggctaga gtcctcactc ccagtccaaa tgtcctccag 1500 aagcctctgg ctagaggcca gccccaccca ggagggaggg ggctatagct acaggaagca 1560 ccccatgcca aagctagggt ggcccttgca gttcagcacc accctagtcc cttcccctcc 1620 ctggctccca tgaccatact gagggaccaa ctgggcccaa gacagatgcc ccagagctgt 1680 ttatggcctc agctgcctca cttcctacaa gagcagcctg tggcatcttt gccttgggct 1740 gctcctcatg gtgggttcag gggactcagc cctgaggtga aagggagcta tcaggaacag 1800 ctatgggagc cccagggtct tccctacctc aggcaggaag ggcaggaagg agagcctgct 1860 gcatggggtg gggtagggct gactagaagg gccagtcctg cctggccagg cagatctgtg 1920 ccccatgcct gtccagcctg ggcagccagg ctgccaaggc cagagtggcc tggccaggag 1980 ctcttcaggc ctccctctct cttctgctcc acccttggcc tgtctcatcc ccaggggtcc 2040 cagccacccc gggctctctg ctgtacatat ttgagactag tttttattcc ttgtgaagat 2100 gatatactat ttttgttaag cgtgtctgta tttatgtgtg aggagctgct ggcttgcagt 2160 gcgcgtgcac gtggagagct ggtgcccgga gattggacgg cctgatgctc cctcccctgc 2220 cctggtccag ggaagctggc cgagggtcct ggctcctgag gggcatctgc ccctccccca 2280 acccccaccc cacacttgtt ccagctcttt gaaatagtct gtgtgaaggt gaaagtgcag 2340 ttcagtaata aactgtgttt actcagtgaa aaaaaaaaaa aaaaaa 2386 <210> 49 <211> 2755 <212> DNA <213> Homo sapiens <400> 49 cctacccgcg cgcaggccaa gttgctgaat caatggagcc ctccccaacc cgggcgttcc 60 ccagcgaggc ttccttccca tcctcctgac caccggggct tttcgtgagc tcgtctctga 120 tctcgcgcaa gagtgacaca caggtgttca aagacgcttc tggggagtga gggaagcggt 180 ttacgagtga cttggctgga gcctcagggg cgggcactgg cacggaacac accctgaggc 240 cagccctggc tgcccaggcg gagctgcctc ttctcccgcg ggttggtgga cccgctcagt 300 acggagttgg ggaagctctt tcacttcgga ggattgctca acaaccatgc tgggcatctg 360 gaccctccta cctctggttc ttacgtctgt tgctagatta tcgtccaaaa gtgttaatgc 420 ccaagtgact gacatcaact ccaagggatt ggaattgagg aagactgtta ctacagttga 480 gactcagaac ttggaaggcc tgcatcatga tggccaattc tgccataagc cctgtcctcc 540 aggtgaaagg aaagctaggg actgcacagt caatggggat gaaccagact gcgtgccctg 600 ccaagaaggg aaggagtaca cagacaaagc ccatttttct tccaaatgca gaagatgtag 660 attgtgtgat gaaggacatg gcttagaagt ggaaataaac tgcacccgga cccagaatac 720 caagtgcaga tgtaaaccaa actttttttg taactctact gtatgtgaac actgtgaccc 780 ttgcaccaaa tgtgaacatg gaatcatcaa ggaatgcaca ctcaccagca acaccaagtg 840 caaagaggaa ggatccagat ctaacttggg gtggctttgt cttcttcttt tgccaattcc 900 actaattgtt tgggtgaaga gaaaggaagt acagaaaaca tgcagaaagc acagaaagga 960 aaaccaaggt tctcatgaat ctccaacctt aaatcctgaa acagtggcaa taaatttatc 1020 tgatgttgac ttgagtaaat atatcaccac tattgctgga gtcatgacac taagtcaagt 1080 taaaggcttt gttcgaaaga atggtgtcaa tgaagccaaa atagatgaga tcaagaatga 1140 caatgtccaa gacacagcag aacagaaagt tcaactgctt cgtaattggc atcaacttca 1200 tggaaagaaa gaagcgtatg acacattgat taaagatctc aaaaaagcca atctttgtac 1260 tcttgcagag aaaattcaga ctatcatcct caaggacatt actagtgact cagaaaattc 1320 aaacttcaga aatgaaatcc aaagcttggt ctagagtgaa aaacaacaaa ttcagttctg 1380 agtatatgca attagtgttt gaaaagattc ttaatagctg gctgtaaata ctgcttggtt 1440 ttttactggg tacattttat catttattag cgctgaagag ccaacatatt tgtagatttt 1500 taatatctca tgattctgcc tccaaggatg tttaaaatct agttgggaaa acaaacttca 1560 tcaagagtaa atgcagtggc atgctaagta cccaaatagg agtgtatgca gaggatgaaa 1620 gattaagatt atgctctggc atctaacata tgattctgta gtatgaatgt aatcagtgta 1680 tgttagtaca aatgtctatc cacaggctaa ccccactcta tgaatcaata gaagaagcta 1740 tgaccttttg ctgaaatatc agttactgaa caggcaggcc actttgcctc taaattacct 1800 ctgataattc tagagatttt accatatttc taaactttgt ttataactct gagaagatca 1860 tatttatgta aagtatatgt atttgagtgc agaatttaaa taaggctcta cctcaaagac 1920 ctttgcacag tttattggtg tcatattata caatatttca attgtgaatt cacatagaaa 1980 acattaaatt ataatgtttg actattatat atgtgtatgc attttactgg ctcaaaacta 2040 cctacttctt tctcaggcat caaaagcatt ttgagcagga gagtattact agagctttgc 2100 cacctctcca tttttgcctt ggtgctcatc ttaatggcct aatgcacccc caaacatgga 2160 aatatcacca aaaaatactt aatagtccac caaaaggcaa gactgccctt agaaattcta 2220 gcctggtttg gagatactaa ctgctctcag agaaagtagc tttgtgacat gtcatgaacc 2280 catgtttgca atcaaagatg ataaaataga ttcttatttt tcccccaccc ccgaaaatgt 2340 tcaataatgt cccatgtaaa acctgctaca aatggcagct tatacatagc aatggtaaaa 2400 tcatcatctg gatttaggaa ttgctcttgt cataccccca agtttctaag atttaagatt 2460 ctccttacta ctatcctacg tttaaatatc tttgaaagtt tgtattaaat gtgaatttta 2520 agaaataata tttatatttc tgtaaatgta aactgtgaag atagttataa actgaagcag 2580 atacctggaa ccacctaaag aacttccatt tatggaggat ttttttgccc cttgtgtttg 2640 gaattataaa atataggtaa aagtacgtaa ttaaataatg tttttggtaa aaaaaaaaaa 2700 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa 2755 <210> 50 <211> 3579 <212> DNA <213> Homo sapiens <400> 50 tcaggctcgc tgtcgcgcca ttttgccggg gtttgaatgt gaggcggagc ggcggcagga 60 gcgggtagtg ccagctacgg tccgcggctg gggttccctc ctccgtttct gtatccccac 120 gagatcctat agcaatggaa ctcagcgatg caaatctgca aacactaaca gaatatttaa 180 agaaaacact tgatcctgat cctgccatcc gacgtccagc tgagaaattt cttgaatctg 240 ttgaaggaaa tcagaattat ccactgttgc ttttgacatt actggagaag tcccaggata 300 atgttatcaa agtatgtgct tcagtaacat tcaaaaacta tattaaaagg aactggagaa 360 ttgttgaaga tgaaccaaac aaaatttgtg aagccgatcg agtggccatt aaagccaaca 420 tagtgcactt gatgcttagc agcccagagc aaattcagaa gcagttaagt gatgcaatta 480 gcattattgg cagagaagat tttccacaga aatggcctga cttgctgaca gaaatggtga 540 atcgctttca gagtggagat ttccatgtta ttaatggagt cctccgtaca gcacattcat 600 tatttaaaag ataccgtcat gaatttaagt caaacgagtt atggactgaa attaagcttg 660 ttctggatgc ctttgctttg cctttgacta atctttttaa ggccactatt gaactctgca 720 gtacccatgc aaatgatgcc tctgccctga ggattctgtt ttcttccctg atcctgatct 780 caaaattgtt ctatagttta aactttcagg atctccctga attttttgaa gataatatgg 840 aaacttggat gaataatttt catactctct taacattgga taataagctt ttacaaactg 900 atgatgaaga ggaagccggc ttattggagc tcttaaaatc ccagatttgt gataatgccg 960 cactctatgc acaaaagtac gatgaagaat tccagcgata cctgcctcgt tttgttacag 1020 ccatctggaa tttactagtt acaacgggtc aagaggttaa atatgatttg ttggtaagta 1080 atgcaattca atttctggct tcagtttgtg agagacctca ttataagaat ctatttgagg 1140 accagaacac gctgacaagt atctgtgaaa aggttattgt gcctaacatg gaatttagag 1200 ctgctgatga agaagcattt gaagataatt ctgaggagta cataaggaga gatttggaag 1260 gatctgatat tgatactaga cgcagggctg cttgtgatct ggtacgagga ttatgcaagt 1320 tttttgaggg acctgtgaca ggaatcttct ctggttatgt taattccatg ctgcaggaat 1380 acgcaaaaaa tccatctgtc aactggaaac acaaagatgc agccatctac ctagtgacat 1440 ctttggcatc aaaagcccaa acacagaagc atggaattac acaagcaaat gaacttgtaa 1500 acctaactga gttctttgtg aatcacatcc tccctgattt aaaatcagct aatgtgaatg 1560 aatttcctgt ccttaaagct gacggtatca aatatattat gatttttaga aatcaagtgc 1620 caaaagaaca tcttttagtc tcgattcctc tcttgattaa tcatcttcaa gctgaaagta 1680 ttgttgttca tacttacgca gctcatgctc ttgaacggct ctttactatg cgagggccta 1740 acaatgccac tctctttaca gctgcagaaa tcgcaccgtt tgttgagatt ctgctaacaa 1800 accttttcaa agctctcaca cttcctggct cttcagaaaa tgaatatatt atgaaagcta 1860 tcatgagaag tttttctctc ctacaagaag ccataatccc ctacatccct actctcatca 1920 ctcagcttac acagaagcta ttagctgtta gtaagaaccc aagcaaacct cactttaatc 1980 actacatgtt tgaagcaata tgtttatcca taagaataac ttgcaaagct aaccctgctg 2040 ctgttgtaaa ttttgaggag gctttgtttt tggtgtttac tgaaatctta caaaatgatg 2100 tgcaagaatt tattccatac gtctttcaag tgatgtcttt gcttctggaa acacacaaaa 2160 atgacatccc gtcttcctat atggccttat ttcctcatct ccttcagcca gtgctttggg 2220 aaagaacagg aaatattcct gctctagtga ggcttcttca agcattctta gaacgcggtt 2280 caaacacaat agcaagtgct gcagctgaca aaattcctgg gttactaggt gtctttcaga 2340 agctgattgc atccaaagca aatgaccacc aaggttttta tcttctaaac agtataatag 2400 agcacatgcc tcctgaatca gttgaccaat ataggaaaca aatcttcatt ctgctattcc 2460 agagacttca gaattccaaa acaaccaagt ttatcaagag ttttttagtc tttattaatt 2520 tgtattgcat aaaatatggg gcactagcac tacaagaaat atttgatggt atacaaccaa 2580 aaatgtttgg aatggttttg gaaaaaatta ttattcctga aattcagaag gtatctggaa 2640 atgtagagaa aaagatctgt gcggttggca taaccaaatt actaacagaa tgtcccccaa 2700 tgatggacac tgagtatacc aaactgtgga ctccattatt acagtctttg attggtcttt 2760 ttgagttacc cgaagatgat accattcctg atgaggaaca ttttattgac atagaagata 2820 caccaggata tcagactgcc ttctcacagt tggcatttgc tgggaaaaaa gagcatgatc 2880 ctgtaggtca aatggtgaat aaccccaaaa ttcacctggc acagtcactt cacaagttgt 2940 ctaccgcctg tccaggaagg gttccatcaa tggtgagcac cagcctgaat gcagaagcgc 3000 tccagtatct ccaagggtac cttcaggcag ccagtgtgac actgctttaa actgcatttt 3060 tctaatgggc taaacccaga tggtttccta ggaaatcaca ggcttctgag cacagctgca 3120 ttaaaacaaa ggaagttctc cttttgaact tgtcacgaat tccatcttgt aaaggatatt 3180 aaatgttgct ttaacctgaa ccttgagcaa attagttggt ttgtgtgatc atacagttat 3240 gtgggtggct tctagtttgc aacttcaagg gacaagtatt aatagttcag tgtatggcgt 3300 tggtttgtgt tgagcgtttg cacggtttgg ataatcttaa attttgacgg acactgtgga 3360 gactttctgt tactaaatcc ttttgttttg aagctgttgc tatttgtatt tctcttgtcc 3420 tttatatttt ttgtctgttt atttacgctt ttattggaaa tgtgaataag taaagaatta 3480 cttgtgttac ttgccaagca gtgcacattt catagtttca aatctgtaat cagcaataaa 3540 aatcctaaaa tatgtaccta aaaaaaaaaa aaaaaaaaa 3579 <210> 51 <211> 8733 <212> DNA <213> Homo sapiens <400> 51 gctcccggct tagaggacag cggggaaggc gggcggtggg gcagggggcc tgaagcggcg 60 gtaccggtgc tggcggcggc agctgaggcc ttggccgaag ccgcgcgaac ctcagggcaa 120 gatgcttgga accggacctg ccgccgccac caccgctgcc accacatcta gcaatgtgag 180 cgtcctgcag cagtttgcca gtggcctaaa gagccggaat gaggaaacca gggccaaagc 240 cgccaaggag ctccagcact atgtcaccat ggaactccga gagatgagtc aagaggagtc 300 tactcgcttc tatgaccaac tgaaccatca catttttgaa ttggtttcca gctcagatgc 360 caatgagagg aaaggtggca tcttggccat agctagcctc ataggagtgg aaggtgggaa 420 tgccacccga attggcagat ttgccaacta tcttcggaac ctcctcccct ccaatgaccc 480 agttgtcatg gaaatggcat ccaaggccat tggccgtctt gccatggcag gggacacttt 540 taccgctgag tacgtggaat ttgaggtgaa gcgagccctg gaatggctgg gtgctgaccg 600 caatgagggc cggagacatg cagctgtcct ggttctccgt gagctggcca tcagcgtccc 660 taccttcttc ttccagcaag tgcaaccctt ctttgacaac atttttgtgg ccgtgtggga 720 ccccaaacag gccatccgtg agggagctgt agccgccctt cgtgcctgtc tgattctcac 780 aacccagcgt gagccgaagg agatgcagaa gcctcagtgg tacaggcaca catttgaaga 840 agcagagaag ggatttgatg agaccttggc caaagagaag ggcatgaatc gggatgatcg 900 gatccatgga gccttgttga tccttaacga gctggtccga atcagcagca tggagggaga 960 gcgtctgaga gaagaaatgg aagaaatcac acagcagcag ctggtacacg acaagtactg 1020 caaagatctc atgggcttcg gaacaaaacc tcgtcacatt acccccttca ccagtttcca 1080 ggctgtacag ccccagcagt caaatgcctt ggtggggctg ctggggtaca gctctcacca 1140 aggcctcatg ggatttggga cctcccccag tccagctaag tccaccctgg tggagagccg 1200 gtgttgcaga gacttgatgg aggagaaatt tgatcaggtg tgccagtggg tgctgaaatg 1260 caggaatagc aagaactcgc tgatccaaat gacaatcctt aatttgttgc cccgcttggc 1320 tgcattccga ccttctgcct tcacagatac ccagtatctc caagatacca tgaaccatgt 1380 cctaagctgt gtcaagaagg agaaggaacg tacagcggcc ttccaagccc tggggctact 1440 ttctgtggct gtgaggtctg agtttaaggt ctatttgcct cgcgtgctgg acatcatccg 1500 agcggccctg cccccaaagg acttcgccca taagaggcag aaggcaatgc aggtggatgc 1560 cacagtcttc acttgcatca gcatgctggc tcgagcaatg gggccaggca tccagcagga 1620 tatcaaggag ctgctggagc ccatgctggc agtgggacta agccctgccc tcactgcagt 1680 gctctacgac ctgagccgtc agattccaca gctaaagaag gacattcaag atgggctact 1740 gaaaatgctg tccctggtcc ttatgcacaa accccttcgc cacccaggca tgcccaaggg 1800 cctggcccat cagctggcct ctcctggcct cacgaccctc cctgaggcca gcgatgtggg 1860 cagcatcact cttgccctcc gaacgcttgg cagctttgaa tttgaaggcc actctctgac 1920 ccaatttgtt cgccactgtg cggatcattt cctgaacagt gagcacaagg agatccgcat 1980 ggaggctgcc cgcacctgct cccgcctgct cacaccctcc atccacctca tcagtggcca 2040 tgctcatgtg gttagccaga ccgcagtgca agtggtggca gatgtgctta gcaaactgct 2100 cgtagttggg ataacagatc ctgaccctga cattcgctac tgtgtcttgg cgtccctgga 2160 cgagcgcttt gatgcacacc tggcccaggc ggagaacttg caggccttgt ttgtggctct 2220 gaatgaccag gtgtttgaga tccgggagct ggccatctgc actgtgggcc gactcagtag 2280 catgaaccct gcctttgtca tgcctttcct gcgcaagatg ctcatccaga ttttgacaga 2340 gttggagcac agtgggattg gaagaatcaa agagcagagt gcccgcatgc tggggcacct 2400 ggtctccaat gccccccgac tcatccgccc ctacatggag cctattctga aggcattaat 2460 tttgaaactg aaagatccag accctgatcc aaacccaggt gtgatcaata atgtcctggc 2520 aacaatagga gaattggcac aggttagtgg cctggaaatg aggaaatggg ttgatgaact 2580 ttttattatc atcatggaca tgctccagga ttcctctttg ttggccaaaa ggcaggtggc 2640 tctgtggacc ctgggacagt tggtggccag cactggctat gtagtagagc cctacaggaa 2700 gtaccctact ttgcttgagg tgctactgaa ttttctgaag actgagcaga accagggtac 2760 acgcagagag gccatccgtg tgttagggct tttaggggct ttggatcctt acaagcacaa 2820 agtgaacatt ggcatgatag accagtcccg ggatgcctct gctgtcagcc tgtcagaatc 2880 caagtcaagt caggattcct ctgactatag cactagtgaa atgctggtca acatgggaaa 2940 cttgcctctg gatgagttct acccagctgt gtccatggtg gccctgatgc ggatcttccg 3000 agaccagtca ctctctcatc atcacaccat ggttgtccag gccatcacct tcatcttcaa 3060 gtccctggga ctcaaatgtg tgcagttcct gccccaggtc atgcccacgt tccttaacgt 3120 cattcgagtc tgtgatgggg ccatccggga atttttgttc cagcagctgg gaatgttggt 3180 gtcctttgtg aagagccaca tcagacctta tatggatgaa atagtcaccc tcatgagaga 3240 attctgggtc atgaacacct caattcagag cacgatcatt cttctcattg agcaaattgt 3300 ggtagctctt gggggtgaat ttaagctcta cctgccccag ctgatcccac acatgctgcg 3360 tgtcttcatg catgacaaca gcccaggccg cattgtctct atcaagttac tggctgcaat 3420 ccagctgttt ggcgccaacc tggatgacta cctgcattta ctgctgcctc ctattgttaa 3480 gttgtttgat gcccctgaag ctccactgcc atctcgaaag gcagcgctag agactgtgga 3540 ccgcctgacg gagtccctgg atttcactga ctatgcctcc cggatcattc accctattgt 3600 tcgaacactg gaccagagcc cagaactgcg ctccacagcc atggacacgc tgtcttcact 3660 tgtttttcag ctggggaaga agtaccaaat tttcattcca atggtgaata aagttctggt 3720 gcgacaccga atcaatcatc agcgctatga tgtgctcatc tgcagaattg tcaagggata 3780 cacacttgct gatgaagagg aggatccttt gatttaccag catcggatgc ttaggagtgg 3840 ccaaggggat gcattggcta gtggaccagt ggaaacagga cccatgaaga aactgcacgt 3900 cagcaccatc aacctccaaa aggcctgggg cgctgccagg agggtctcca aagatgactg 3960 gctggaatgg ctgagacggc tgagcctgga gctgctgaag gactcatcat cgccctccct 4020 gcgctcctgc tgggccctgg cacaggccta caacccgatg gccagggatc tcttcaatgc 4080 tgcatttgtg tcctgctggt ctgaactgaa tgaagatcaa caggatgagc tcatcagaag 4140 catcgagttg gccctcacct cacaagacat cgctgaagtc acacagaccc tcttaaactt 4200 ggctgaattc atggaacaca gtgacaaggg ccccctgcca ctgagagatg acaatggcat 4260 tgttctgctg ggtgagagag ctgccaagtg ccgagcatat gccaaagcac tacactacaa 4320 agaactggag ttccagaaag gccccacccc tgccattcta gaatctctca tcagcattaa 4380 taataagcta cagcagccgg aggcagcggc cggagtgtta gaatatgcca tgaaacactt 4440 tggagagctg gagatccagg ctacctggta tgagaaactg cacgagtggg aggatgccct 4500 tgtggcctat gacaagaaaa tggacaccaa caaggacgac ccagagctga tgctgggccg 4560 catgcgctgc ctcgaggcct tgggggaatg gggtcaactc caccagcagt gctgtgaaaa 4620 gtggaccctg gttaatgatg agacccaagc caagatggcc cggatggctg ctgcagctgc 4680 atggggttta ggtcagtggg acagcatgga agaatacacc tgtatgatcc ctcgggacac 4740 ccatgatggg gcattttata gagctgtgct ggcactgcat caggacctct tctccttggc 4800 acaacagtgc attgacaagg ccagggacct gctggatgct gaattaactg cgatggcagg 4860 agagagttac agtcgggcat atggggccat ggtttcttgc cacatgctgt ccgagctgga 4920 ggaggttatc cagtacaaac ttgtccccga gcgacgagag atcatccgcc agatctggtg 4980 ggagagactg cagggctgcc agcgtatcgt agaggactgg cagaaaatcc ttatggtgcg 5040 gtcccttgtg gtcagccctc atgaagacat gagaacctgg ctcaagtatg caagcctgtg 5100 cggcaagagt ggcaggctgg ctcttgctca taaaacttta gtgttgctcc tgggagttga 5160 tccgtctcgg caacttgacc atcctctgcc aacagttcac cctcaggtga cctatgccta 5220 catgaaaaac atgtggaaga gtgcccgcaa gatcgatgcc ttccagcaca tgcagcattt 5280 tgtccagacc atgcagcaac aggcccagca tgccatcgct actgaggacc agcagcataa 5340 gcaggaactg cacaagctca tggcccgatg cttcctgaaa cttggagagt ggcagctgaa 5400 tctacagggc atcaatgaga gcacaatccc caaagtgctg cagtactaca gcgccgccac 5460 agagcacgac cgcagctggt acaaggcctg gcatgcgtgg gcagtgatga acttcgaagc 5520 tgtgctacac tacaaacatc agaaccaagc ccgcgatgag aagaagaaac tgcgtcatgc 5580 cagcggggcc aacatcacca acgccaccac tgccgccacc acggccgcca ctgccaccac 5640 cactgccagc accgagggca gcaacagtga gagcgaggcc gagagcaccg agaacagccc 5700 caccccatcg ccgctgcaga agaaggtcac tgaggatctg tccaaaaccc tcctgatgta 5760 cacggtgcct gccgtccagg gcttcttccg ttccatctcc ttgtcacgag gcaacaacct 5820 ccaggataca ctcagagttc tcaccttatg gtttgattat ggtcactggc cagatgtcaa 5880 tgaggcctta gtggaggggg tgaaagccat ccagattgat acctggctac aggttatacc 5940 tcagctcatt gcaagaattg atacgcccag acccttggtg ggacgtctca ttcaccagct 6000 tctcacagac attggtcggt accaccccca ggccctcatc tacccactga cagtggcttc 6060 taagtctacc acgacagccc ggcacaatgc agccaacaag attctgaaga acatgtgtga 6120 gcacagcaac accctggtcc agcaggccat gatggtgagc gaggagctga tccgagtggc 6180 catcctctgg catgagatgt ggcatgaagg cctggaagag gcatctcgtt tgtactttgg 6240 ggaaaggaac gtgaaaggca tgtttgaggt gctggagccc ttgcatgcta tgatggaacg 6300 gggcccccag actctgaagg aaacatcctt taatcaggcc tatggtcgag atttaatgga 6360 ggcccaagag tggtgcagga agtacatgaa atcagggaat gtcaaggacc tcacccaagc 6420 ctgggacctc tattatcatg tgttccgacg aatctcaaag cagctgcctc agctcacatc 6480 cttagagctg caatatgttt ccccaaaact tctgatgtgc cgggaccttg aattggctgt 6540 gccaggaaca tatgacccca accagccaat cattcgcatt cagtccatag caccgtcttt 6600 gcaagtcatc acatccaagc agaggccccg gaaattgaca cttatgggca gcaacggaca 6660 tgagtttgtt ttccttctaa aaggccatga agatctgcgc caggatgagc gtgtgatgca 6720 gctcttcggc ctggttaaca cccttctggc caatgaccca acatctcttc ggaaaaacct 6780 cagcatccag agatacgctg tcatcccttt atcgaccaac tcgggcctca ttggctgggt 6840 tccccactgt gacacactgc acgccctcat ccgggactac agggagaaga agaagatcct 6900 tctcaacatc gagcatcgca tcatgttgcg gatggctccg gactatgacc acttgactct 6960 gatgcagaag gtggaggtgt ttgagcatgc cgtcaataat acagctgggg acgacctggc 7020 caagctgctg tggctgaaaa gccccagctc cgaggtgtgg tttgaccgaa gaaccaatta 7080 tacccgttct ttagcggtca tgtcaatggt tgggtatatt ttaggcctgg gagatagaca 7140 cccatccaac ctgatgctgg accgtctgag tgggaagatc ctgcacattg actttgggga 7200 ctgctttgag gttgctatga cccgagagaa gtttccagag aagattccat ttagactaac 7260 aagaatgttg accaatgcta tggaggttac aggcctggat ggcaactaca gaatcacatg 7320 ccacacagtg atggaggtgc tgcgagagca caaggacagt gtcatggccg tgctggaagc 7380 ctttgtctat gaccccttgc tgaactggag gctgatggac acaaatacca aaggcaacaa 7440 gcgatcccga acgaggacgg attcctactc tgctggccag tcagtcgaaa ttttggacgg 7500 tgtggaactt ggagagccag cccataagaa aacggggacc acagtgccag aatctattca 7560 ttctttcatt ggagacggtt tggtgaaacc agaggcccta aataagaaag ctatccagat 7620 tattaacagg gttcgagata agctcactgg tcgggacttc tctcatgatg acactttgga 7680 tgttccaacg caagttgagc tgctcatcaa acaagcgaca tcccatgaaa acctctgcca 7740 gtgctatatt ggctggtgcc ctttctggta actggaggcc cagatgtgcc catcacgttt 7800 tttctgaggc ttttgtactt tagtaaatgc ttccactaaa ctgaaaccat ggtgagaaag 7860 tttgactttg ttaaatattt tgaaatgtaa atgaaaagaa ctactgtata ttaaaagttg 7920 gtttgaacca actttctagc tgctgttgaa gaatatattg tcagaaacac aaggcttgat 7980 ttggttccca ggacagtgaa acatagtaat accacgtaaa tcaagccatt cattttgggg 8040 aacagaagat ccataacttt agaaatacgg gttttgactt aactcacaag agaactcatc 8100 ataagtactt gctgatggaa gaatgaccta gttgctcctc tcaacatggg tacagcaaac 8160 tcagcacagc caagaagcct caggtcgtgg agaacatgga ttaggatcct agactgtaaa 8220 gacacagaag atgctgacct cacccctgcc acctatccca agacctcact ggtctgtgga 8280 cagcagcaga aatgtttgca agataggcca aaatgagtac aaaaggtctg tcttccatca 8340 gacccagtga tgctgcgact cacacgcttc aattcaagac ctgaccgcta gtagggaggt 8400 ttattcagat cgctggcagc ctcggctgag cagatgcaca gaggggatca ctgtgcagtg 8460 ggaccaccct cactggcctt ctgcagcagg gttctgggat gttttcagtg gtcaaaatac 8520 tctgtttaga gcaagggctc agaaaacaga aatactgtca tggaggtgct gaacacaggg 8580 aaggtctggt acatattgga aattatgagc agaacaaata ctcaactaaa tgcacaaagt 8640 ataaagtgta gccatgtcta gacaccatgt tgtatcagaa taatttttgt gccaataaat 8700 gacatcagaa ttttaaacat atgtaaaaaa aaa 8733 <210> 52 <211> 3008 <212> DNA <213> Homo sapiens <400> 52 taattatggg tctgtaacca ccctggactg ggtgctcctc actgacggac ttgtctgaac 60 ctctctttgt ctccagcgcc cagcactggg cctggcaaaa cctgagacgc ccggtacatg 120 ttggccaaat gaatgaacca gattcagacc ggcaggggcg ctgtggttta ggaggggcct 180 ggggtttctc ccaggaggtt tttgggcttg cgctggaggg ctctggactc ccgtttgcgc 240 cagtggcctg catcctggtc ctgtcttcct catgtttgaa tttctttgct ttcctagtct 300 ggggagcagg gaggagccct gtgccctgtc ccaggatcca tgggtaggaa caccatggac 360 agggagagca aacggggcca tctgtcacca ggggcttagg gaaggccgag ccagcctggg 420 tcaaagaagt caaaggggct gcctggagga ggcagcctgt cagctggtgc atcagaggct 480 gtggccaggc cagctgggct cggggagcgc cagcctgaga ggagcgcgtg agcgtcgcgg 540 gagcctcggg caccatgagc gacgtggcta ttgtgaagga gggttggctg cacaaacgag 600 gggagtacat caagacctgg cggccacgct acttcctcct caagaatgat ggcaccttca 660 ttggctacaa ggagcggccg caggatgtgg accaacgtga ggctcccctc aacaacttct 720 ctgtggcgca gtgccagctg atgaagacgg agcggccccg gcccaacacc ttcatcatcc 780 gctgcctgca gtggaccact gtcatcgaac gcaccttcca tgtggagact cctgaggagc 840 gggaggagtg gacaaccgcc atccagactg tggctgacgg cctcaagaag caggaggagg 900 aggagatgga cttccggtcg ggctcaccca gtgacaactc aggggctgaa gagatggagg 960 tgtccctggc caagcccaag caccgcgtga ccatgaacga gtttgagtac ctgaagctgc 1020 tgggcaaggg cactttcggc aaggtgatcc tggtgaagga gaaggccaca ggccgctact 1080 acgccatgaa gatcctcaag aaggaagtca tcgtggccaa ggacgaggtg gcccacacac 1140 tcaccgagaa ccgcgtcctg cagaactcca ggcacccctt cctcacagcc ctgaagtact 1200 ctttccagac ccacgaccgc ctctgctttg tcatggagta cgccaacggg ggcgagctgt 1260 tcttccacct gtcccgggag cgtgtgttct ccgaggaccg ggcccgcttc tatggcgctg 1320 agattgtgtc agccctggac tacctgcact cggagaagaa cgtggtgtac cgggacctca 1380 agctggagaa cctcatgctg gacaaggacg ggcacattaa gatcacagac ttcgggctgt 1440 gcaaggaggg gatcaaggac ggtgccacca tgaagacctt ttgcggcaca cctgagtacc 1500 tggcccccga ggtgctggag gacaatgact acggccgtgc agtggactgg tgggggctgg 1560 gcgtggtcat gtacgagatg atgtgcggtc gcctgccctt ctacaaccag gaccatgaga 1620 agctttttga gctcatcctc atggaggaga tccgcttccc gcgcacgctt ggtcccgagg 1680 ccaagtcctt gctttcaggg ctgctcaaga aggaccccaa gcagaggctt ggcgggggct 1740 ccgaggacgc caaggagatc atgcagcatc gcttctttgc cggtatcgtg tggcagcacg 1800 tgtacgagaa gaagctcagc ccacccttca agccccaggt cacgtcggag actgacacca 1860 ggtattttga tgaggagttc acggcccaga tgatcaccat cacaccacct gaccaagatg 1920 acagcatgga gtgtgtggac agcgagcgca ggccccactt cccccagttc tcctactcgg 1980 ccagcggcac ggcctgaggc ggcggtggac tgcgctggac gatagcttgg agggatggag 2040 aggcggcctc gtgccatgat ctgtatttaa tggtttttat ttctcgggtg catttgagag 2100 aagccacgct gtcctctcga gcccagatgg aaagacgttt ttgtgctgtg ggcagcaccc 2160 tcccccgcag cggggtaggg aagaaaacta tcctgcgggt tttaatttat ttcatccagt 2220 ttgttctccg ggtgtggcct cagccctcag aacaatccga ttcacgtagg gaaatgttaa 2280 ggacttctgc agctatgcgc aatgtggcat tggggggccg ggcaggtcct gcccatgtgt 2340 cccctcactc tgtcagccag ccgccctggg ctgtctgtca ccagctatct gtcatctctc 2400 tggggccctg ggcctcagtt caacctggtg gcaccagatg caacctcact atggtatgct 2460 ggccagcacc ctctcctggg ggtggcaggc acacagcagc cccccagcac taaggccgtg 2520 tctctgagga cgtcatcgga ggctgggccc ctgggatggg accagggatg ggggatgggc 2580 cagggtttac ccagtgggac agaggagcaa ggtttaaatt tgttattgtg tattatgttg 2640 ttcaaatgca ttttgggggt ttttaatctt tgtgacagga aagccctccc ccttcccctt 2700 ctgtgtcaca gttcttggtg actgtcccac cgggagcctc cccctcagat gatctctcca 2760 cggtagcact tgaccttttc gacgcttaac ctttccgctg tcgccccagg ccctccctga 2820 ctccctgtgg gggtggccat ccctgggccc ctccacgcct cctggccaga cgctgccgct 2880 gccgctgcac cacggcgttt ttttacaaca ttcaacttta gtatttttac tattataata 2940 taatatggaa ccttccctcc aaattcttca ataaaagttg cttttcaaaa aaaaaaaaaa 3000 aaaaaaaa 3008 <210> 53 <211> 891 <212> DNA <213> Homo sapiens <400> 53 tcacgtgacc cgggcgcgct gcggccgccc gcgcggaccc ggcgagaggc ggcggcggga 60 gcggcggtga tggacgggtc cggggagcag cccagaggcg gggggcccac cagctctgag 120 cagatcatga agacaggggc ccttttgctt cagggtttca tccaggatcg agcagggcga 180 atgggggggg aggcacccga gctggccctg gacccggtgc ctcaggatgc gtccaccaag 240 aagctgagcg agtgtctcaa gcgcatcggg gacgaactgg acagtaacat ggagctgcag 300 aggatgattg ccgccgtgga cacagactcc ccccgagagg tctttttccg agtggcagct 360 gacatgtttt ctgacggcaa cttcaactgg ggccgggttg tcgccctttt ctactttgcc 420 agcaaactgg tgctcaaggc cctgtgcacc aaggtgccgg aactgatcag aaccatcatg 480 ggctggacat tggacttcct ccgggagcgg ctgttgggct ggatccaaga ccagggtggt 540 tgggtgagac tcctcaagcc tcctcacccc caccaccgcg ccctcaccac cgcccctgcc 600 ccaccgtccc tgccccccgc cactcctctg ggaccctggg ccttctggag caggtcacag 660 tggtgccctc tccccatctt cagatcatca gatgtggtct ataatgcgtt ttccttacgt 720 gtctgatcaa tccccgattc atctaccctg ctgacctccc agtgacccct gacctcactg 780 tgaccttgac ttgattagtg ccttctgccc tccctggagc ctccactgcc tctggaattg 840 ctcaagttca ttgatgaccc tctgacccta gctctttcct tttttttttt t 891 <210> 54 <211> 6492 <212> DNA <213> Homo sapiens <400> 54 tttctgtgaa gcagaagtct gggaatcgat ctggaaatcc tcctaatttt tactccctct 60 ccccgcgact cctgattcat tgggaagttt caaatcagct ataactggag agtgctgaag 120 attgatggga tcgttgcctt atgcatttgt tttggtttta caaaaaggaa acttgacaga 180 ggatcatgct gtacttaaaa aatacaacat cacagaggaa gtagactgat attaacaata 240 cttactaata ataacgtgcc tcatgaaata aagatccgaa aggaattgga ataaaaattt 300 cctgcatctc atgccaaggg ggaaacacca gaatcaagtg ttccgcgtga ttgaagacac 360 cccctcgtcc aagaatgcaa agcacatcca ataaaatagc tggattataa ctcctcttct 420 ttctctgggg gccgtggggt gggagctggg gcgagaggtg ccgttggccc ccgttgcttt 480 tcctctggga aggatggcgc acgctgggag aacagggtac gataaccggg agatagtgat 540 gaagtacatc cattataagc tgtcgcagag gggctacgag tgggatgcgg gagatgtggg 600 cgccgcgccc ccgggggccg cccccgcacc gggcatcttc tcctcccagc ccgggcacac 660 gccccatcca gccgcatccc gggacccggt cgccaggacc tcgccgctgc agaccccggc 720 tgcccccggc gccgccgcgg ggcctgcgct cagcccggtg ccacctgtgg tccacctgac 780 cctccgccag gccggcgacg acttctcccg ccgctaccgc cgcgacttcg ccgagatgtc 840 cagccagctg cacctgacgc ccttcaccgc gcggggacgc tttgccacgg tggtggagga 900 gctcttcagg gacggggtga actgggggag gattgtggcc ttctttgagt tcggtggggt 960 catgtgtgtg gagagcgtca accgggagat gtcgcccctg gtggacaaca tcgccctgtg 1020 gatgactgag tacctgaacc ggcacctgca cacctggatc caggataacg gaggctggga 1080 tgcctttgtg gaactgtacg gccccagcat gcggcctctg tttgatttct cctggctgtc 1140 tctgaagact ctgctcagtt tggccctggt gggagcttgc atcaccctgg gtgcctatct 1200 gggccacaag tgaagtcaac atgcctgccc caaacaaata tgcaaaaggt tcactaaagc 1260 agtagaaata atatgcattg tcagtgatgt accatgaaac aaagctgcag gctgtttaag 1320 aaaaaataac acacatataa acatcacaca cacagacaga cacacacaca cacaacaatt 1380 aacagtcttc aggcaaaacg tcgaatcagc tatttactgc caaagggaaa tatcatttat 1440 tttttacatt attaagaaaa aaagatttat ttatttaaga cagtcccatc aaaactcctg 1500 tctttggaaa tccgaccact aattgccaag caccgcttcg tgtggctcca cctggatgtt 1560 ctgtgcctgt aaacatagat tcgctttcca tgttgttggc cggatcacca tctgaagagc 1620 agacggatgg aaaaaggacc tgatcattgg ggaagctggc tttctggctg ctggaggctg 1680 gggagaaggt gttcattcac ttgcatttct ttgccctggg ggctgtgata ttaacagagg 1740 gagggttcct gtggggggaa gtccatgcct ccctggcctg aagaagagac tctttgcata 1800 tgactcacat gatgcatacc tggtgggagg aaaagagttg ggaacttcag atggacctag 1860 tacccactga gatttccacg ccgaaggaca gcgatgggaa aaatgccctt aaatcatagg 1920 aaagtatttt tttaagctac caattgtgcc gagaaaagca ttttagcaat ttatacaata 1980 tcatccagta ccttaagccc tgattgtgta tattcatata ttttggatac gcacccccca 2040 actcccaata ctggctctgt ctgagtaaga aacagaatcc tctggaactt gaggaagtga 2100 acatttcggt gacttccgca tcaggaaggc tagagttacc cagagcatca ggccgccaca 2160 agtgcctgct tttaggagac cgaagtccgc agaacctgcc tgtgtcccag cttggaggcc 2220 tggtcctgga actgagccgg ggccctcact ggcctcctcc agggatgatc aacagggcag 2280 tgtggtctcc gaatgtctgg aagctgatgg agctcagaat tccactgtca agaaagagca 2340 gtagaggggt gtggctgggc ctgtcaccct ggggccctcc aggtaggccc gttttcacgt 2400 ggagcatggg agccacgacc cttcttaaga catgtatcac tgtagaggga aggaacagag 2460 gccctgggcc cttcctatca gaaggacatg gtgaaggctg ggaacgtgag gagaggcaat 2520 ggccacggcc cattttggct gtagcacatg gcacgttggc tgtgtggcct tggcccacct 2580 gtgagtttaa agcaaggctt taaatgactt tggagagggt cacaaatcct aaaagaagca 2640 ttgaagtgag gtgtcatgga ttaattgacc cctgtctatg gaattacatg taaaacatta 2700 tcttgtcact gtagtttggt tttatttgaa aacctgacaa aaaaaaagtt ccaggtgtgg 2760 aatatggggg ttatctgtac atcctggggc attaaaaaaa aaatcaatgg tggggaacta 2820 taaagaagta acaaaagaag tgacatcttc agcaaataaa ctaggaaatt tttttttctt 2880 ccagtttaga atcagccttg aaacattgat ggaataactc tgtggcatta ttgcattata 2940 taccatttat ctgtattaac tttggaatgt actctgttca atgtttaatg ctgtggttga 3000 tatttcgaaa gctgctttaa aaaaatacat gcatctcagc gtttttttgt ttttaattgt 3060 atttagttat ggcctataca ctatttgtga gcaaaggtga tcgttttctg tttgagattt 3120 ttatctcttg attcttcaaa agcattctga gaaggtgaga taagccctga gtctcagcta 3180 cctaagaaaa acctggatgt cactggccac tgaggagctt tgtttcaacc aagtcatgtg 3240 catttccacg tcaacagaat tgtttattgt gacagttata tctgttgtcc ctttgacctt 3300 gtttcttgaa ggtttcctcg tccctgggca attccgcatt taattcatgg tattcaggat 3360 tacatgcatg tttggttaaa cccatgagat tcattcagtt aaaaatccag atggcaaatg 3420 accagcagat tcaaatctat ggtggtttga cctttagaga gttgctttac gtggcctgtt 3480 tcaacacaga cccacccaga gccctcctgc cctccttccg cgggggcttt ctcatggctg 3540 tccttcaggg tcttcctgaa atgcagtggt gcttacgctc caccaagaaa gcaggaaacc 3600 tgtggtatga agccagacct ccccggcggg cctcagggaa cagaatgatc agacctttga 3660 atgattctaa tttttaagca aaatattatt ttatgaaagg tttacattgt caaagtgatg 3720 aatatggaat atccaatcct gtgctgctat cctgccaaaa tcattttaat ggagtcagtt 3780 tgcagtatgc tccacgtggt aagatcctcc aagctgcttt agaagtaaca atgaagaacg 3840 tggacgtttt taatataaag cctgttttgt cttttgttgt tgttcaaacg ggattcacag 3900 agtatttgaa aaatgtatat atattaagag gtcacggggg ctaattgctg gctggctgcc 3960 ttttgctgtg gggttttgtt acctggtttt aataacagta aatgtgccca gcctcttggc 4020 cccagaactg tacagtattg tggctgcact tgctctaaga gtagttgatg ttgcattttc 4080 cttattgtta aaaacatgtt agaagcaatg aatgtatata aaagcctcaa ctagtcattt 4140 ttttctcctc ttcttttttt tcattatatc taattatttt gcagttgggc aacagagaac 4200 catccctatt ttgtattgaa gagggattca catctgcatc ttaactgctc tttatgaatg 4260 aaaaaacagt cctctgtatg tactcctctt tacactggcc agggtcagag ttaaatagag 4320 tatatgcact ttccaaattg gggacaaggg ctctaaaaaa agccccaaaa ggagaagaac 4380 atctgagaac ctcctcggcc ctcccagtcc ctcgctgcac aaatactccg caagagaggc 4440 cagaatgaca gctgacaggg tctatggcca tcgggtcgtc tccgaagatt tggcaggggc 4500 agaaaactct ggcaggctta agatttggaa taaagtcaca gaattaagga agcacctcaa 4560 tttagttcaa acaagacgcc aacattctct ccacagctca cttacctctc tgtgttcaga 4620 tgtggccttc catttatatg tgatctttgt tttattagta aatgcttatc atctaaagat 4680 gtagctctgg cccagtggga aaaattagga agtgattata aatcgagagg agttataata 4740 atcaagatta aatgtaaata atcagggcaa tcccaacaca tgtctagctt tcacctccag 4800 gatctattga gtgaacagaa ttgcaaatag tctctatttg taattgaact tatcctaaaa 4860 caaatagttt ataaatgtga acttaaactc taattaattc caactgtact tttaaggcag 4920 tggctgtttt tagactttct tatcacttat agttagtaat gtacacctac tctatcagag 4980 aaaaacagga aaggctcgaa atacaagcca ttctaaggaa attagggagt cagttgaaat 5040 tctattctga tcttattctg tggtgtcttt tgcagcccag acaaatgtgg ttacacactt 5100 tttaagaaat acaattctac attgtcaagc ttatgaaggt tccaatcaga tctttattgt 5160 tattcaattt ggatctttca gggatttttt ttttaaatta ttatgggaca aaggacattt 5220 gttggagggg tgggagggag gaagaatttt taaatgtaaa acattcccaa gtttggatca 5280 gggagttgga agttttcaga ataaccagaa ctaagggtat gaaggacctg tattggggtc 5340 gatgtgatgc ctctgcgaag aaccttgtgt gacaaatgag aaacattttg aagtttgtgg 5400 tacgaccttt agattccaga gacatcagca tggctcaaag tgcagctccg tttggcagtg 5460 caatggtata aatttcaagc tggatatgtc taatgggtat ttaaacaata aatgtgcagt 5520 tttaactaac aggatattta atgacaacct tctggttggt agggacatct gtttctaaat 5580 gtttattatg tacaatacag aaaaaaattt tataaaatta agcaatgtga aactgaattg 5640 gagagtgata atacaagtcc tttagtctta cccagtgaat cattctgttc catgtctttg 5700 gacaaccatg accttggaca atcatgaaat atgcatctca ctggatgcaa agaaaatcag 5760 atggagcatg aatggtactg taccggttca tctggactgc cccagaaaaa taacttcaag 5820 caaacatcct atcaacaaca aggttgttct gcataccaag ctgagcacag aagatgggaa 5880 cactggtgga ggatggaaag gctcgctcaa tcaagaaaat tctgagacta ttaataaata 5940 agactgtagt gtagatactg agtaaatcca tgcacctaaa ccttttggaa aatctgccgt 6000 gggccctcca gatagctcat ttcattaagt ttttccctcc aaggtagaat ttgcaagagt 6060 gacagtggat tgcatttctt ttggggaagc tttcttttgg tggttttgtt tattatacct 6120 tcttaagttt tcaaccaagg tttgcttttg ttttgagtta ctggggttat ttttgtttta 6180 aataaaaata agtgtacaat aagtgttttt gtattgaaag cttttgttat caagattttc 6240 atacttttac cttccatggc tctttttaag attgatactt ttaagaggtg gctgatattc 6300 tgcaacactg tacacataaa aaatacggta aggatacttt acatggttaa ggtaaagtaa 6360 gtctccagtt ggccaccatt agctataatg gcactttgtt tgtgttgttg gaaaaagtca 6420 cattgccatt aaactttcct tgtctgtcta gttaatattg tgaagaaaaa taaagtacag 6480 tgtgagatac tg 6492 <210> 55 <211> 5572 <212> DNA <213> Homo sapiens <400> 55 cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc 60 ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt 120 gatgtggcgg gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact 180 gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc 240 tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga 300 gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct 360 gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct 420 cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg 480 aggcgcggcg gcggcggcgg cacctcccgc tcctggagcg ggggggagaa gcggcggcgg 540 cggcggccgc ggcggctgca gctccaggga gggggtctga gtcgcctgtc accatttcca 600 gggctgggaa cgccggagag ttggtctctc cccttctact gcctccaaca cggcggcggc 660 ggcggcggca catccaggga cccgggccgg ttttaaacct cccgtccgcc gccgccgcac 720 cccccgtggc ccgggctccg gaggccgccg gcggaggcag ccgttcggag gattattcgt 780 cttctcccca ttccgctgcc gccgctgcca ggcctctggc tgctgaggag aagcaggccc 840 agtcgctgca accatccagc agccgccgca gcagccatta cccggctgcg gtccagagcc 900 aagcggcggc agagcgaggg gcatcagcta ccgccaagtc cagagccatt tccatcctgc 960 agaagaagcc ccgccaccag cagcttctgc catctctctc ctcctttttc ttcagccaca 1020 ggctcccaga catgacagcc atcatcaaag agatcgttag cagaaacaaa aggagatatc 1080 aagaggatgg attcgactta gacttgacct atatttatcc aaacattatt gctatgggat 1140 ttcctgcaga aagacttgaa ggcgtataca ggaacaatat tgatgatgta gtaaggtttt 1200 tggattcaaa gcataaaaac cattacaaga tatacaatct ttgtgctgaa agacattatg 1260 acaccgccaa atttaattgc agagttgcac aatatccttt tgaagaccat aacccaccac 1320 agctagaact tatcaaaccc ttttgtgaag atcttgacca atggctaagt gaagatgaca 1380 atcatgttgc agcaattcac tgtaaagctg gaaagggacg aactggtgta atgatatgtg 1440 catatttatt acatcggggc aaatttttaa aggcacaaga ggccctagat ttctatgggg 1500 aagtaaggac cagagacaaa aagggagtaa ctattcccag tcagaggcgc tatgtgtatt 1560 attatagcta cctgttaaag aatcatctgg attatagacc agtggcactg ttgtttcaca 1620 agatgatgtt tgaaactatt ccaatgttca gtggcggaac ttgcaatcct cagtttgtgg 1680 tctgccagct aaaggtgaag atatattcct ccaattcagg acccacacga cgggaagaca 1740 agttcatgta ctttgagttc cctcagccgt tacctgtgtg tggtgatatc aaagtagagt 1800 tcttccacaa acagaacaag atgctaaaaa aggacaaaat gtttcacttt tgggtaaata 1860 cattcttcat accaggacca gaggaaacct cagaaaaagt agaaaatgga agtctatgtg 1920 atcaagaaat cgatagcatt tgcagtatag agcgtgcaga taatgacaag gaatatctag 1980 tacttacttt aacaaaaaat gatcttgaca aagcaaataa agacaaagcc aaccgatact 2040 tttctccaaa ttttaaggtg aagctgtact tcacaaaaac agtagaggag ccgtcaaatc 2100 cagaggctag cagttcaact tctgtaacac cagatgttag tgacaatgaa cctgatcatt 2160 atagatattc tgacaccact gactctgatc cagagaatga accttttgat gaagatcagc 2220 atacacaaat tacaaaagtc tgaatttttt tttatcaaga gggataaaac accatgaaaa 2280 taaacttgaa taaactgaaa atggaccttt ttttttttaa tggcaatagg acattgtgtc 2340 agattaccag ttataggaac aattctcttt tcctgaccaa tcttgtttta ccctatacat 2400 ccacagggtt ttgacacttg ttgtccagtt gaaaaaaggt tgtgtagctg tgtcatgtat 2460 ataccttttt gtgtcaaaag gacatttaaa attcaattag gattaataaa gatggcactt 2520 tcccgtttta ttccagtttt ataaaaagtg gagacagact gatgtgtata cgtaggaatt 2580 ttttcctttt gtgttctgtc accaactgaa gtggctaaag agctttgtga tatactggtt 2640 cacatcctac ccctttgcac ttgtggcaac agataagttt gcagttggct aagagaggtt 2700 tccgaagggt tttgctacat tctaatgcat gtattcgggt taggggaatg gagggaatgc 2760 tcagaaagga aataatttta tgctggactc tggaccatat accatctcca gctatttaca 2820 cacacctttc tttagcatgc tacagttatt aatctggaca ttcgaggaat tggccgctgt 2880 cactgcttgt tgtttgcgca ttttttttta aagcatattg gtgctagaaa aggcagctaa 2940 aggaagtgaa tctgtattgg ggtacaggaa tgaaccttct gcaacatctt aagatccaca 3000 aatgaaggga tataaaaata atgtcatagg taagaaacac agcaacaatg acttaaccat 3060 ataaatgtgg aggctatcaa caaagaatgg gcttgaaaca ttataaaaat tgacaatgat 3120 ttattaaata tgttttctca attgtaacga cttctccatc tcctgtgtaa tcaaggccag 3180 tgctaaaatt cagatgctgt tagtacctac atcagtcaac aacttacact tattttacta 3240 gttttcaatc ataatacctg ctgtggatgc ttcatgtgct gcctgcaagc ttcttttttc 3300 tcattaaata taaaatattt tgtaatgctg cacagaaatt ttcaatttga gattctacag 3360 taagcgtttt ttttctttga agatttatga tgcacttatt caatagctgt cagccgttcc 3420 acccttttga ccttacacat tctattacaa tgaattttgc agttttgcac attttttaaa 3480 tgtcattaac tgttagggaa ttttacttga atactgaata catataatgt ttatattaaa 3540 aaggacattt gtgttaaaaa ggaaattaga gttgcagtaa actttcaatg ctgcacacaa 3600 aaaaaagaca tttgattttt cagtagaaat tgtcctacat gtgctttatt gatttgctat 3660 tgaaagaata gggttttttt tttttttttt tttttttttt ttaaatgtgc agtgttgaat 3720 catttcttca tagtgctccc ccgagttggg actagggctt caatttcact tcttaaaaaa 3780 aatcatcata tatttgatat gcccagactg catacgattt taagcggagt acaactacta 3840 ttgtaaagct aatgtgaaga tattattaaa aaggtttttt tttccagaaa tttggtgtct 3900 tcaaattata ccttcacctt gacatttgaa tatccagcca ttttgtttct taatggtata 3960 aaattccatt ttcaataact tattggtgct gaaattgttc actagctgtg gtctgaccta 4020 gttaatttac aaatacagat tgaataggac ctactagagc agcatttata gagtttgatg 4080 gcaaatagat taggcagaac ttcatctaaa atattcttag taaataatgt tgacacgttt 4140 tccatacctt gtcagtttca ttcaacaatt tttaaatttt taacaaagct cttaggattt 4200 acacatttat atttaaacat tgatatatag agtattgatt gattgctcat aagttaaatt 4260 ggtaaagtta gagacaacta ttctaacacc tcaccattga aatttatatg ccaccttgtc 4320 tttcataaaa gctgaaaatt gttacctaaa atgaaaatca acttcatgtt ttgaagatag 4380 ttataaatat tgttctttgt tacaatttcg ggcaccgcat attaaaacgt aactttattg 4440 ttccaatatg taacatggag ggccaggtca taaataatga cattataatg ggcttttgca 4500 ctgttattat ttttcctttg gaatgtgaag gtctgaatga gggttttgat tttgaatgtt 4560 tcaatgtttt tgagaagcct tgcttacatt ttatggtgta gtcattggaa atggaaaaat 4620 ggcattatat atattatata tataaatata tattatacat actctcctta ctttatttca 4680 gttaccatcc ccatagaatt tgacaagaat tgctatgact gaaaggtttt cgagtcctaa 4740 ttaaaacttt atttatggca gtattcataa ttagcctgaa atgcattctg taggtaatct 4800 ctgagtttct ggaatatttt cttagacttt ttggatgtgc agcagcttac atgtctgaag 4860 ttacttgaag gcatcacttt taagaaagct tacagttggg ccctgtacca tcccaagtcc 4920 tttgtagctc ctcttgaaca tgtttgccat acttttaaaa gggtagttga ataaatagca 4980 tcaccattct ttgctgtggc acaggttata aacttaagtg gagtttaccg gcagcatcaa 5040 atgtttcagc tttaaaaaat aaaagtaggg tacaagttta atgtttagtt ctagaaattt 5100 tgtgcaatat gttcataacg atggctgtgg ttgccacaaa gtgcctcgtt tacctttaaa 5160 tactgttaat gtgtcatgca tgcagatgga aggggtggaa ctgtgcacta aagtgggggc 5220 tttaactgta gtatttggca gagttgcctt ctacctgcca gttcaaaagt tcaacctgtt 5280 ttcatataga atatatatac taaaaaattt cagtctgtta aacagcctta ctctgattca 5340 gcctcttcag atactcttgt gctgtgcagc agtggctctg tgtgtaaatg ctatgcactg 5400 aggatacaca aaaataccaa tatgatgtgt acaggataat gcctcatccc aatcagatgt 5460 ccatttgtta ttgtgtttgt taacaaccct ttatctctta gtgttataaa ctccacttaa 5520 aactgattaa agtctcattc ttgtcaaaaa aaaaaaaaaa aaaaaaaaaa aa 5572 <210> 56 <211> 2609 <212> DNA <213> Homo sapiens <400> 56 acattggccg gcgccggcct ccgcccccgc ctctccgcca atcaccgccc gcctgctccc 60 ctcgccgtgg gtccccgcga ggccgccacc ccggggtcgc cgtctccgcc tcgccgcagt 120 cggggcagcc gctcgcccct cttttccatg tatccgtcca ggatcccatg acagattctg 180 ttgtcacgtc tccttacaga gtttgagcgg tgctgaactg tcagcaccat ctgtccggtc 240 ccagcatgcc ttctgagacc ccccaggcag aagtggggcc cacaggctgc ccccaccgct 300 cagggccaca ctcggcgaag gggagcctgg agaaggggtc cccagaggat aaggaagcca 360 aggagcccct gtggatccgg cccgatgctc cgagcaggtg cacctggcag ctgggccggc 420 ctgcctccga gtccccacat caccacactg ccccggcaaa atctccaaaa atcttgccag 480 atattctgaa gaaaatcggg gacaccccta tggtcagaat caacaagatt gggaagaagt 540 tcggcctgaa gtgtgagctc ttggccaagt gtgagttctt caacgcgggc gggagcgtga 600 aggaccgcat cagcctgcgg atgattgagg atgctgagcg cgacgggacg ctgaagcccg 660 gggacacgat tatcgagccg acatccggga acaccgggat cgggctggcc ctggctgcgg 720 cagtgagggg ctatcgctgc atcatcgtga tgccagagaa gatgagctcc gagaaggtgg 780 acgtgctgcg ggcactgggg gctgagattg tgaggacgcc caccaatgcc aggttcgact 840 ccccggagtc acacgtgggg gtggcctggc ggctgaagaa cgaaatcccc aattctcaca 900 tcctagacca gtaccgcaac gccagcaacc ccctggctca ctacgacacc accgctgatg 960 agatcctgca gcagtgtgat gggaagctgg acatgctggt ggcttcagtg ggcacgggcg 1020 gcaccatcac gggcattgcc aggaagctga aggagaagtg tcctggatgc aggatcattg 1080 gggtggatcc cgaagggtcc atcctcgcag agccggagga gctgaaccag acggagcaga 1140 caacctacga ggtggaaggg atcggctacg acttcatccc cacggtgctg gacaggacgg 1200 tggtggacaa gtggttcaag agcaacgatg aggaggcgtt cacctttgcc cgcatgctga 1260 tcgcgcaaga ggggctgctg tgcggtggca gtgctggcag cacggtggcg gtggccgtga 1320 aggccgcgca ggagctgcag gagggccagc gctgcgtggt cattctgccc gactcagtgc 1380 ggaactacat gaccaagttc ctgagcgaca ggtggatgct gcagaagggc tttctgaagg 1440 aggaggacct cacggagaag aagccctggt ggtggcacct ccgtgttcag gagctgggcc 1500 tgtcagcccc gctgaccgtg ctcccgacca tcacctgtgg gcacaccatc gagatcctcc 1560 gggagaaggg cttcgaccag gcgcccgtgg tggatgaggc gggggtaatc ctgggaatgg 1620 tgacgcttgg gaacatgctc tcgtccctgc ttgccgggaa ggtgcagccg tcagaccaag 1680 ttggcaaagt catctacaag cagttcaaac agatccgcct cacggacacg ctgggcaggc 1740 tctcgcacat cctggagatg gaccacttcg ccctggtggt gcacgagcag atccagtacc 1800 acagcaccgg gaagtccagt cagcggcaga tggtgttcgg ggtggtcacc gccattgact 1860 tgctgaactt cgtggccgcc caggagcggg accagaagtg aagtccggag cgctgggcgg 1920 tgcggagcgg gcccgccacc cttgcccact tctccttcgc tttcctgagc cctaaacaca 1980 cgcgtgattg gtaactgcct ggcctggcac cgttatccct gcacacggca cagagcatcc 2040 gtctcccctc gttaacacat ggcttcctaa atggccctgt ttacggccta tgagatgaaa 2100 tatgtgattt tctctaatgt aacttcctct taggatgttt caccaaggaa atattgagag 2160 agaagtcggc caggtaggat gaacacaggc aatgactgcg cagagtggat taaaggcaaa 2220 agagagaaga gtccaggaag gggcggggag aagcctgggt ggctcagcat cctccacggg 2280 ctgcgccgtc tgctcggggc tgagctggcg ggagcagttt gcgtgtttgg gttttttaat 2340 tgagatgaaa ttcaaataac ctaaaaatca atcacttgaa agtgaacaat cagcggcatt 2400 tagtacatcc agaaagttgt gtaggcacca cctctgtcac gttctggaac attctgtcat 2460 caccccgtga agcaatcatt tcccctcccg tcttcctcct cccctggcaa ctgctgatcg 2520 actttgtgtc tctgttgtct aaaataggtt ttccctgttc tggacatttc atataaatgg 2580 aatcacacaa aaaaaaaaaa aaaaaaaaa 2609 <210> 57 <211> 8413 <212> DNA <213> Homo sapiens <400> 57 tttccagatt ggggctcggg ccgcgcctcc tccgggaccc tccccttgga ccgagccgat 60 cgccgcgggg cagttcgggc cggctgtcct ggcgcgaaaa ggtggacaag tcctattttc 120 aagagaagat gacttttaac agttttgaag gatctaaaac ttgtgtacct gcagacatca 180 ataaggaaga agaatttgta gaagagttta atagattaaa aacttttgct aattttccaa 240 gtggtagtcc tgtttcagca tcaacactgg cacgagcagg gtttctttat actggtgaag 300 gagataccgt gcggtgcttt agttgtcatg cagctgtaga tagatggcaa tatggagact 360 cagcagttgg aagacacagg aaagtatccc caaattgcag atttatcaac ggcttttatc 420 ttgaaaatag tgccacgcag tctacaaatt ctggtatcca gaatggtcag tacaaagttg 480 aaaactatct gggaagcaga gatcattttg ccttagacag gccatctgag acacatgcag 540 actatctttt gagaactggg caggttgtag atatatcaga caccatatac ccgaggaacc 600 ctgccatgta tagtgaagaa gctagattaa agtcctttca gaactggcca gactatgctc 660 acctaacccc aagagagtta gcaagtgctg gactctacta cacaggtatt ggtgaccaag 720 tgcagtgctt ttgttgtggt ggaaaactga aaaattggga accttgtgat cgtgcctggt 780 cagaacacag gcgacacttt cctaattgct tctttgtttt gggccggaat cttaatattc 840 gaagtgaatc tgatgctgtg agttctgata ggaatttccc aaattcaaca aatcttccaa 900 gaaatccatc catggcagat tatgaagcac ggatctttac ttttgggaca tggatatact 960 cagttaacaa ggagcagctt gcaagagctg gattttatgc tttaggtgaa ggtgataaag 1020 taaagtgctt tcactgtgga ggagggctaa ctgattggaa gcccagtgaa gacccttggg 1080 aacaacatgc taaatggtat ccagggtgca aatatctgtt agaacagaag ggacaagaat 1140 atataaacaa tattcattta actcattcac ttgaggagtg tctggtaaga actactgaga 1200 aaacaccatc actaactaga agaattgatg ataccatctt ccaaaatcct atggtacaag 1260 aagctatacg aatggggttc agtttcaagg acattaagaa aataatggag gaaaaaattc 1320 agatatctgg gagcaactat aaatcacttg aggttctggt tgcagatcta gtgaatgctc 1380 agaaagacag tatgcaagat gagtcaagtc agacttcatt acagaaagag attagtactg 1440 aagagcagct aaggcgcctg caagaggaga agctttgcaa aatctgtatg gatagaaata 1500 ttgctatcgt ttttgttcct tgtggacatc tagtcacttg taaacaatgt gctgaagcag 1560 ttgacaagtg tcccatgtgc tacacagtca ttactttcaa gcaaaaaatt tttatgtctt 1620 aatctaactc tatagtaggc atgttatgtt gttcttatta ccctgattga atgtgtgatg 1680 tgaactgact ttaagtaatc aggattgaat tccattagca tttgctacca agtaggaaaa 1740 aaaatgtaca tggcagtgtt ttagttggca atataatctt tgaatttctt gatttttcag 1800 ggtattagct gtattatcca ttttttttac tgttatttaa ttgaaaccat agactaagaa 1860 taagaagcat catactataa ctgaacacaa tgtgtattca tagtatactg atttaatttc 1920 taagtgtaag tgaattaatc atctggattt tttattcttt tcagataggc ttaacaaatg 1980 gagctttctg tatataaatg tggagattag agttaatctc cccaatcaca taatttgttt 2040 tgtgtgaaaa aggaataaat tgttccatgc tggtggaaag atagagattg tttttagagg 2100 ttggttgttg tgttttagga ttctgtccat tttcttttaa agttataaac acgtacttgt 2160 gcgaattatt tttttaaagt gatttgccat ttttgaaagc gtatttaatg atagaatact 2220 atcgagccaa catgtactga catggaaaga tgtcaaagat atgttaagtg taaaatgcaa 2280 gtggcaaaac actatgtata gtctgagcca gatcaaagta tgtatgtttt taatatgcat 2340 agaacaaaag atttggaaag atatacacca aactgttaaa tgtggtttct cttcggggag 2400 ggggggattg ggggaggggc cccagagggg ttttataggg gccttttcac tttctacttt 2460 tttcattttg ttctgttcga attttttata agtatgtatt acttttgtaa tcagaatttt 2520 tagaaagtat tttgctgatt taaaggctta ggcatgttca aacgcctgca aaactactta 2580 tcactcagct ttagtttttc taatccaaga aggcagggca gttaaccttt ttggtgccaa 2640 tgtgaaatgt aaatgatttt atgtttttcc tgctttgtgg atgaaaaata tttctgagtg 2700 gtagtttttt gacaggtaga ccatgtctta tcttgtttca aaataagtat ttctgatttt 2760 gtaaaatgaa atataaaata tgtctcagat cttccaatta attagtaagg attcatcctt 2820 aatccttgct agtttaagcc tgcctaagtc actttactaa aagatctttg ttaactcagt 2880 attttaaaca tctgtcagct tatgtaggta aaagtagaag catgtttgta cactgcttgt 2940 agttatagtg acagctttcc atgttgagat tctcatatca tcttgtatct taaagtttca 3000 tgtgagtttt taccgttagg atgattaaga tgtatatagg acaaaatgtt aagtctttcc 3060 tctacctaca tttgttttct tggctagtaa tagtagtaga tacttctgaa ataaatgttc 3120 tctcaagatc cttaaaacct cttggaaatt ataaaaatat tggcaagaaa agaagaatag 3180 ttgtttaaat attttttaaa aaacacttga ataagaatca gtagggtata aactagaagt 3240 ttaaaaatgc ttcatagaac gtccagggtt tacattacaa gattctcaca acaaacctat 3300 tgtagaggtg agtaaggcat gttactacag aggaaagttt gagagtaaaa ctgtaaaaaa 3360 ttatattttt gttgtacttt ctaagagaaa gagtattgtt atgttctcct aacttctgtt 3420 gattactact ttaagtgata ttcatttaaa acattgcaaa tttattttat ttatttaatt 3480 ttctttttga gatggagtct tgcttgtcac ccaggctgga gtgcagtgga gtgatctctg 3540 ctcactgcaa cctccgcctt ctgggttcaa gcgattctcg tgcctcagct tcctgagtag 3600 ctggaattac aggcaggtgc caccatgccc gactaatttt tttttatttt tagtagagac 3660 ggggtttcac catgttggcc aggctggtat caaactcctg acctcaagag atccactcgc 3720 cttgccctcc caaagtgctg ggattacagg cttgagccac cacgcccggc taaaacattg 3780 caaatttaaa tgagagtttt aaaaattaaa taatgactgc cctgtttctg ttttagtatg 3840 taaatcctca gttcttcacc tttgcactgt ctgccactta gtttggttat atagtcatta 3900 acttgaattt ggtctgtata gtctagactt taaatttaaa gttttctaca aggggagaaa 3960 agtgttaaaa tttttaaaat atgttttcca ggacacttca cttccaagtc aggtaggtag 4020 ttcaatctag ttgttagcca aggactcaag gactgaattg ttttaacata aggcttttcc 4080 tgttctggga gccgcacttc attaaaattc ttctaaaact tgtatgttta gagttaagca 4140 agactttttt tcttcctctc catgagttgt gaaatttaat gcacaacgct gatgtggcta 4200 acaagtttat tttaagaatt gtttagaaat gctgttgctt caggttctta aaatcactca 4260 gcactccaac ttctaatcaa atttttggag acttaacagc atttgtctgt gtttgaacta 4320 taaaaagcac cggatctttt ccatctaatt ccgcaaaaat tgatcatttg caaagtcaaa 4380 actatagcca tatccaaatc ttttccccct cccaagagtt ctcagtgtct acatgtagac 4440 tattcctttt ctgtataaag ttcactctag gatttcaagt caccacttat tttacatttt 4500 agtcatgcaa agattcaagt agttttgcaa taagtactta tctttatttg taataattta 4560 gtctgctgat caaaagcatt gtcttaattt ttgagaactg gttttagcat ttacaaacta 4620 aattccagtt aattaattaa tagctttata ttgcctttcc tgctacattt ggttttttcc 4680 cctgtccctt tgattacggg ctaaggtagg gtagagtggg tgtagtgagt gtatataatg 4740 tgatttggcc ctgtgtatta tgatattttg ttatttttgt tgttatatta tttacatttc 4800 agtagttgtt ttttgtgttt ccattttagt ggataaaatt tgtattttga actatgaatg 4860 gagactaccg ccccagcatt agtttcacat gatataccct ttaaacccga atcattgttt 4920 tatttcctga ttacacaggt gttgaatggg gaaaggggct agtatatcag taggatatac 4980 tatgggatgt atatatatca ttgctgttag agaaatgaaa taaaatgggg ctgggctcag 5040 tggctcacgc ctgtaatccc agcactttgg gaggctgagg caggtggatc acgaggtcag 5100 gagatcgaga ccatcctggc taacacggtg aaaccccgtc tctactaaaa aacagaaaat 5160 tagccgggcg tggtggcggg cgcctgtagt cccagctact cgggaggctg aggcaggaga 5220 atggtgtgaa cccgggaggc agagcttgca gtgagccgag atctcgccac tgcactccag 5280 cctgggcaac agagcaagac tctgtctcaa aaaaaaaaaa aaaagaaata agaaaatggg 5340 aagcaatatt tgacatagtt ctttttagtc aaatctactt gttaaaaaaa gggtagcagt 5400 ttattcatct gtgaaaggaa aataatactt atcttacaag gttgcaagag ctcaaggaga 5460 ccatgtatgt aaagttcctg ctgtaaatat gaactcccat cctaataccc ttttacctct 5520 ctgtgggttt gtcttgacct ggaaatttgg gctaaaactt agaaaaaatt cttacatgat 5580 aactcagtga tgcttactca tagtttttgg tgtttctcat agataagata taaatcagct 5640 gggcgcggtg gctcatgcct gtaatcccag cactttggga ggccgaggcg ggcagatcac 5700 ctgaggtcgg gaggtcgaga ccagcctgac caacatggag aaaccccgtc tctactaaaa 5760 atacaaaatt agctgggcgt ggtggctcat gcctgtaatc ccagctactt gggaggctga 5820 ggcaggagaa tcgcttgaac ccaggaggcg gaggttgtgg tgagcgaaga tcgtgccatt 5880 gcactccagc ctgggcaaca agagcaaaac tctgtctcaa aaaaaaaaaa agatataaat 5940 cacaataaat aaataggtca atacaaatgt tagccaggcg tggtggcaca tgcccatagt 6000 cgcagctact ctggaggcag aggcaggagg atcacttgag cccatgaatt tgaggcagca 6060 gtgagctatg attgtgccac tgtactccag tctgggtgac agagtgagac cccatctcta 6120 aataaatagg tcaaaccctt aaaaatattt aaattcttaa aaaattgaaa agattattct 6180 tctcaaattt agttgagctt tctaagagaa gcaattggct ttttcccact tcaataatca 6240 ttttcagttt gactcataca gttaacacaa tgtgaatttc ttcctcagca taacagagtt 6300 atagaatgac agggctggaa gtgaccttag agagtatcca gttctttcat tttacaggtg 6360 aggcaactga gactcaaagg tgatgtaatt tgtgcaaaga ttatagctaa ttagtagcag 6420 agccctgact gggacatagt ttgaaggtga aaaacttcac caagctacct ttcttgaaag 6480 gtccaaatgt ttatgttttc aactactctt tccactgtac cataactttc actacatatt 6540 aaatgacact ttataactaa tataatagga caatcatcaa tgcatatata gccagccctt 6600 catatctgtg ggttttgcat ccatggattc aaccaaggag gaattgaaaa cactgagaaa 6660 aaaaaaaaag accacacaat aaaaaaaaaa aatacaaaat aatacaaaga aaaagccaaa 6720 attgtcatac tgttgttaag caacagtata acaactattt acatagcatt aaggttggtg 6780 caaaaatgca aaaaaaaaaa aagcaattat ttttaaacca acctaatata ttgtattagg 6840 tattaaagtc atctggacat gaattaaagt atatgatgcc agcctggaca aaaggcaaaa 6900 ccctgtctct acaaaaaata caaaaattag ctgggcatgg tggtgtgtgc ctgtagtcct 6960 ggctactccg gagcctgagg tgggaggatc gcttgagtct gggaggcaga ggctgcattg 7020 agctatgatc atggcactgc attccagcct gggtgacagt gcaagacctt gtctcagaat 7080 aaataaagta tgtgatgaag atgtgcatac attatatgca aatactgttt tttttttttt 7140 taatttaaac agtctcactg tgttgcccag gatggagtgc aatggcacaa tcttggctca 7200 tggcaaactc tgcctcgcaa gcagctggga ctacaggcat gctccacggt gcccagttaa 7260 ttttttttgt attcttagta gagacagggt ttcaccatgt tggccaggct agtcttgaat 7320 ttctgacctc aagtgattca tctcccaaag tgctgggatt acaggcgtga gccaccacgg 7380 ccggctaatt tttgtatttt ttagtagtga ctggtttcgc ggtgttgacc aggctggtct 7440 cgaactcctg atctcaggtg atctgcctgc ctcggcctca caaagtgctg ggattacagg 7500 tgtgaaccac tgctcccggc cttgtgtgat tttatctaag ggacttaagc gtcctcaggt 7560 cctagggggt cgtgaaacca aaaccccagg gatagcaagg gacaattgta tcttcaaagt 7620 agacaaatgg cgccgggcac ggtggctcac gcctgtaatc ccagcagttt ccgaggctga 7680 ggcaggcggc tcacctgagg tcaggagttg gagaccagcc tggccaacat gctgaaaccc 7740 tgtctgtaca aaaatacaaa aatagctggg catggtggcg catgcctgta gtcccagcta 7800 ctagagcgac tgaggcagga gaattgcttg aacctgggag gcggaggttg cagggagcca 7860 agatggcgcc accgcactcc agcctaggtg atagagtgag actccctctc aaaaacaaaa 7920 caaaacaaaa aaattagaca aatgctacat taatgtttgg gtggtcagat tctactttga 7980 atctgaagtt tgcagatatg cctatagatt tttggagttt accactttct tattctgtat 8040 cattaatgta atattttaaa ttactatata tgttaccatt tttctggatt tagtaagaaa 8100 tttgcagttt tggtttgatg taacaagggt tttaatgtaa tttatgttag attttgcatt 8160 tttttcatta ctgttatatt ttaacctgac tgactgatct aattgtatta gtattgtgaa 8220 taatcatgtg aaatgttttg agacagagta ctatatttgt gaatataatt ttatggtttt 8280 tttcacttag aacctttctg tgtggaaaac taagaaaatt gctttctgct gtataatctg 8340 gcattcattg tagattaaag cttatttttc tgtgaataaa acgtattcaa taaaatacta 8400 ttctttaaaa tta 8413 <210> 58 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 58 aatgtgcacc ctagccaaga a 21 <210> 59 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 59 tgctcgctgg gtaggagagt 20 <210> 60 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 60 agaagccctc tccgggcacc g 21 <210> 61 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 61 cggcagaagc cgagttca 18 <210> 62 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 62 gcttgtgttg ggtggatatt gtt 23 <210> 63 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 63 catcctcctg gccaccgact cctac 25 <210> 64 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 64 gccagagagc caggagcat 19 <210> 65 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 65 ggtgtcacac agataaactt ggtctt 26 <210> 66 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 66 agctgaccca ggcgctgccc 20 <210> 67 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 67 tggtttccaa ggtgtgagta cttg 24 <210> 68 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 68 gggctgtctg atgtggatag c 21 <210> 69 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 69 tcatccgtca agttcaagcc agttaccctc 30 <210> 70 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 70 caagcctacc gtcccacaga 20 <210> 71 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 71 ccagtaactg tctctcttgc aaatg 25 <210> 72 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 72 cccaaaaatc gaaacagagg aaacgaacag 30 <210> 73 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 73 ggttgtctga agtcactgca cagt 24 <210> 74 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 74 ctcggtaggg acatgctaag tagag 25 <210> 75 <211> 28 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 75 catctcagcc cacatagtga tggttccc 28 <210> 76 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 76 tgcctccggg actgaca 17 <210> 77 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 77 tgaccctgac tttcacattg atg 23 <210> 78 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 78 tgccttctct cccctgtcat ttccag 26 <210> 79 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 79 cggacaaggc ccgttatg 18 <210> 80 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 80 agaggaagaa ggccgaagga 20 <210> 81 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 81 aaaagaagtt caaggatccc aatgcaccc 29 <210> 82 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 82 aaaaacctcc acgaacacaa aaa 23 <210> 83 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 83 tgcttggtct aaaagtgtga caatc 25 <210> 84 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 84 tcagagttgc cacccacacc tcttca 26 <210> 85 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 85 cggaagacga aggcaattca 20 <210> 86 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 86 gccgacttgg gcaccttt 18 <210> 87 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 87 ccagaaactg cggaactcgg cca 23 <210> 88 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 88 gccccgcccc tagtctta 18 <210> 89 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 89 accgaccaca gccttgca 18 <210> 90 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 90 ctcgcactga agcgccgatt cc 22 <210> 91 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 91 ccgagtccgt gtctaccaga tt 22 <210> 92 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 92 cacatgtccc caccttattg g 21 <210> 93 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 93 tctgcctctg aactcacggc tggtgt 26 <210> 94 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 94 tctgcctgaa ctggtacatg ct 22 <210> 95 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 95 tggattgata ccactaccaa aaaca 25 <210> 96 <211> 28 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 96 tggtcctcct ggcacattat catgcttt 28 <210> 97 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 97 aacgactgct actccaagct caa 23 <210> 98 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 98 ggatttccat cttgctcacc tt 22 <210> 99 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 99 tgcccagcat cccccagaac aa 22 <210> 100 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 100 gctgcctttg gtctctggtt t 21 <210> 101 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 101 agaaatgcaa tgctcagtct agga 24 <210> 102 <211> 28 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 102 agtcccgtgt ctctcgctat ttctgctg 28 <210> 103 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 103 tgccgggaag agcacaa 17 <210> 104 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 104 tccatctctc cgaacacttc ttg 23 <210> 105 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 105 acacccggac tcttccgtca atttcg 26 <210> 106 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 106 gctccacctt cgatgctctc t 21 <210> 107 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 107 tgctcgactg ctggaagga 19 <210> 108 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 108 atcacccgcc atcccctcca ac 22 <210> 109 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 109 ccaatttgtc cccacaatgc 20 <210> 110 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 110 gggcggcgat tctctca 17 <210> 111 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 111 cctcctgcac gcaatggtgg c 21 <210> 112 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 112 cgttgttgca tgctctttgt g 21 <210> 113 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 113 ccagcaaaaa cttaatctgc ttca 24 <210> 114 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 114 ccaagggaga cgccagagca tcc 23 <210> 115 <211> 16 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 115 gacccggcca cgaaca 16 <210> 116 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 116 gtcgagctgg gcagacaga 19 <210> 117 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 117 tttcatacaa gacgtgggcc tgtaccctg 29 <210> 118 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 118 gatggcactc agcgaatgc 19 <210> 119 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 119 atgcgcacat ctccattgac 20 <210> 120 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 120 ctccctgcag aagcgtcccg ac 22 <210> 121 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 121 tcctgggtgc attcagtctc t 21 <210> 122 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 122 ggagctgcac agcctttaaa gt 22 <210> 123 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 123 tgcctctgcc tgcctcctgg tc 22 <210> 124 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 124 tcccagtatg atggccagtc a 21 <210> 125 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 125 ataaggccag ccaaaactca ag 22 <210> 126 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 126 atgctgctct tcccgtccac aagtg 25 <210> 127 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 127 aaatctgaaa gcggctgata ctg 23 <210> 128 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 128 cggaaccgct tccttcatag 20 <210> 129 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 129 ccccacagcc ccgccttatg a 21 <210> 130 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 130 gagatccagc ttgcctcctc tt 22 <210> 131 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 131 cggttttact tcttctcagt cctgta 26 <210> 132 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 132 agcaacaggg tcccgtcctt gaca 24 <210> 133 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 133 cagtggaggc cgacttcttg 20 <210> 134 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 134 atgaaccagg agccatcctt t 21 <210> 135 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 135 tccacagcac ctggttatta ttcttggcg 29 <210> 136 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 136 gatggtgtct ctcgcagatt ca 22 <210> 137 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 137 tcagatgcct ccccaatcag 20 <210> 138 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 138 atgtccacag aaagtgccaa cagcttcac 29 <210> 139 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 139 gcacccgcct cagtcaact 19 <210> 140 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 140 caacatggta ccggcatgaa 20 <210> 141 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 141 aatgaaaacc cttattttgc ccccaatcc 29 <210> 142 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 142 tccgcgtccc actagca 17 <210> 143 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 143 agttatccag ctccagagtc tctagac 27 <210> 144 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 144 caccccctca gcagggccg 19 <210> 145 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 145 gggctcccgt cctgctt 17 <210> 146 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 146 actcctccct ttcctccaga ac 22 <210> 147 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 147 tgccatgtaa atccccactg ggacc 25 <210> 148 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 148 gcttactctc acctgcttct gagtt 25 <210> 149 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 149 tgggctgctt cttccaaca 19 <210> 150 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 150 agaccactgg cagatgtccc ggc 23 <210> 151 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 151 cgacagcttc gatttgaatg ac 22 <210> 152 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 152 gggagcgtcg caaagga 17 <210> 153 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 153 tgtaattgcg tccccctact ccggc 25 <210> 154 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 154 aatcacattc agctggtgaa actg 24 <210> 155 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 155 tgccagcttg gtttctgctt 20 <210> 156 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 156 aagaggtgca ccagctctcc cgg 23 <210> 157 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 157 ctggaccacc tgatgaatat ctgt 24 <210> 158 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 158 caatgctacg aaggtcctga ca 22 <210> 159 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 159 cagctgcgcc tgctctccga 20 <210> 160 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 160 tgcactcaga tttaagcctt acaaa 25 <210> 161 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 161 tcaccacgag tgaccttcat g 21 <210> 162 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 162 aagcctctgg ccgtcacacg tagg 24 <210> 163 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 163 aaccagcaca gcatggtgag t 21 <210> 164 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 164 cctcgtcttt ctcctgctcg ta 22 <210> 165 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 165 tccacgccca tcgcggaca 19 <210> 166 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 166 cggatgaatg agcctccaa 19 <210> 167 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 167 ggacattatc aaaccgtgaa agaa 24 <210> 168 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 168 tcttgggctt gtgcctcacc agatc 25 <210> 169 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 169 gaggctgtgt ccagtgcagt ag 22 <210> 170 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 170 ccacttcttg gtacccggtt aa 22 <210> 171 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 171 cctggcatca ctgtcaccca cctg 24 <210> 172 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 172 tgaagatctc aatgaagtag ccaaactat 29 <210> 173 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 173 ctgcagtggg tttgccaat 19 <210> 174 <211> 28 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 174 caacattcat gaagactgaa gccccaca 28 <210> 175 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 175 ttccccccaa ggagttcct 19 <210> 176 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 176 cgctcgtgtt cctcatgct 19 <210> 177 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 177 acccgaagcg cacggccac 19 <210> 178 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 178 ccattgaaaa tcaccctcat ctg 23 <210> 179 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 179 cacctcagca tgcctgcat 19 <210> 180 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 180 caccacctcc catgtgttca gttcacc 27 <210> 181 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 181 cagccgcctt cattatctcc ta 22 <210> 182 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 182 tggaggtgtt gttcccgtat c 21 <210> 183 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 183 tgctctccgg gcacgtcaac c 21 <210> 184 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 184 tttcctccac tgccatcatt aa 22 <210> 185 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 185 ggccaaaggt ttcagcttca 20 <210> 186 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 186 cctcagctgt gacatgaaag acttaccgg 29 <210> 187 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 187 ttgaggtgat ctcgcaaagt tatt 24 <210> 188 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 188 ctcgccacca gggagaaa 18 <210> 189 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 189 ccaccatggc caacaacgaa ggac 24 <210> 190 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 190 ggcagttgcc taccatctca taa 23 <210> 191 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 191 gccgagtcag gtgatgatca 20 <210> 192 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 192 tctatttggc gacaagccca cctgatt 27 <210> 193 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 193 ccttctgatt gatggtgcta ttttg 25 <210> 194 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 194 gcggtgagcc gagatcac 18 <210> 195 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 195 cagaatctcg ctctgtcgcc cagg 24 <210> 196 <211> 14 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 196 tcgcggccgc atgt 14 <210> 197 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 197 aagggtccag cactatcaag aga 23 <210> 198 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 198 agcaggtcct gggcgcctca ac 22 <210> 199 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 199 gattgccttt gttttgatgt ttgt 24 <210> 200 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 200 ggaaagggaa cccaggttag tg 22 <210> 201 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 201 cagaattgat cattttcccc ccactctcc 29 <210> 202 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 202 aatggtgtca atgaagccaa aat 23 <210> 203 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 203 gtcatacgct tctttctttc catga 25 <210> 204 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 204 tgacaatgtc caagacacag cagaacagaa 30 <210> 205 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 205 gcatgatcct gtaggtcaaa tgg 23 <210> 206 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 206 caggcggtag acaacttgtg aa 22 <210> 207 <211> 30 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 207 aataacccca aaattcacct ggcacagtca 30 <210> 208 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 208 aggccgcatt gtctctatca a 21 <210> 209 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 209 gcagtaaatg caggtagtca tcca 24 <210> 210 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 210 tgcaatccag ctgtttggcg cc 22 <210> 211 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 211 tctcgggtgc atttgagaga a 21 <210> 212 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 212 acagcacaaa aacgtctttc ca 22 <210> 213 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 213 ccacgctgtc ctctcgagcc ca 22 <210> 214 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 214 ggttgtcgcc cttttctact ttg 23 <210> 215 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 215 cagttccggc accttggt 18 <210> 216 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 216 cagcaaactg gtgctcaagg ccct 24 <210> 217 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 217 catgtgtgtg gagagcgtca a 21 <210> 218 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 218 gccggttcag gtactcagtc a 21 <210> 219 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 219 cctggtggac aacatcgccc tgt 23 <210> 220 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 220 tggcggaact tgcaatcc 18 <210> 221 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 221 gctgagggaa ctcaaagtac atga 24 <210> 222 <211> 29 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 222 atattcctcc aattcaggac ccacacgac 29 <210> 223 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 223 gttggcaaag tcatctacaa gca 23 <210> 224 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 224 gggcgaagtg gtccatctc 19 <210> 225 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 225 acgctgggca ggctctcgca c 21 <210> 226 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 226 gacaggccat ctgagacaca tg 22 <210> 227 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 227 agcatagtct ggccagttct gaa 23 <210> 228 <211> 28 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 228 agacaccata tacccgagga accctgcc 28 <210> 229 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 229 cattcgggcc gagatgtct 19 <210> 230 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 230 ctccaggcca gaaagagaga gtag 24 <210> 231 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 231 ccgtggcctt agctgtgctc gc 22 <210> 232 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 232 cacatggcct ccaaggagta a 21 <210> 233 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 233 tgagggtctc tctcttcctc ttgt 24 <210> 234 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 234 ctggaccacc agccccagca ag 22 <210> 235 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 235 ccagggattt gcctcacctt 20 <210> 236 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 236 aaagagatga agcccccaca t 21 <210> 237 <211> 26 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 237 ccttgatgac tgccttgcct cctcag 26 <210> 238 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 238 gctcgagatg tgatgaagga gat 23 <210> 239 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 239 ccagcaggtc agcaaagaat t 21 <210> 240 <211> 28 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 240 ccatcacatt gtagccctct gtgtgctc 28 <210> 241 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> forward primer <400> 241 cacctagtgg ctgggagctt 20 <210> 242 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> reverse primer <400> 242 gcccagtttt atcatctcac aaga 24 <210> 243 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> probe <400> 243 tggcacttac ctttgtccct tgcttca 27

Claims (41)

An expression pattern, or both, of a liver cancer prognostic marker comprising HMGB2 (high-mobility group box 2) represented by SEQ ID NO: 16 and CDH1 (cadherin 1) represented by SEQ ID NO: 24, / RTI &gt; for the prognosis of liver cancer. The composition according to claim 1, wherein the nucleic acid is a probe or a primer. The composition according to claim 1, wherein said liver cancer prognosis prediction is a prognosis prediction after liver cancer resection. The method according to claim 1, wherein the expression level, expression pattern, or both of the liver cancer prognostic markers is specifically detected by RT-PCR, competitive RT-PCR, real-time RT- Wherein the composition is predicted by at least one selected from the group consisting of PCR, RNase protection assay, Northern blot, and DNA microarray. An expression pattern, or both of the expression pattern or both of the liver cancer prognostic marker comprising HMGB2 (high-mobility group box 2) shown in SEQ ID NO: 16 and CDH1 (cadherin 1) A composition for predicting the prognosis of liver cancer comprising an antibody of a sex marker. 6. The composition of claim 5, wherein said liver cancer prognosis prediction is a prognosis prediction after liver cancer resection. 6. The method according to claim 5, wherein specific expression of the expression level, expression pattern, or both of the liver cancer prognostic marker is detected by Western blotting, enzyme linked immunosorbent assay (ELISA), radioimmunoassay, radioimmunodiffusion, Which is composed of Ouchterlony immunodiffusion method, rocket immunoelectrophoresis, tissue immuno staining, Immunoprecipitation Assay, Complement Fixation Assay, FACS, or protein chip Wherein the composition comprises at least one selected from the group consisting of: &lt; RTI ID = 0.0 &gt; An expression pattern, or both, of a liver cancer prognostic marker comprising HMGB2 (high-mobility group box 2) represented by SEQ ID NO: 16 and CDH1 (cadherin 1) represented by SEQ ID NO: 24, A liver cancer prognosis prediction kit. 9. The kit according to claim 8, wherein the nucleic acid is a probe or a primer. 9. The kit according to claim 8, wherein the prognosis of liver cancer is predictive of prognosis after liver cancer resection. 9. The method of claim 8, wherein the expression level, expression pattern, or both of the liver cancer prognostic markers is specifically detected by RT-PCR, competitive RT-PCR, real-time RT- A kit for predicting the prognosis of liver cancer, which is detected by at least one selected from the group consisting of PCR, RNase protection assay, northern blot, and DNA microarray. An expression pattern, or both of the expression pattern or both of the liver cancer prognostic marker comprising HMGB2 (high-mobility group box 2) shown in SEQ ID NO: 16 and CDH1 (cadherin 1) A kit for predicting prognosis of liver cancer comprising an antibody of a sex marker. 14. The kit according to claim 12, wherein the prognosis of liver cancer is predictive of prognosis after liver cancer resection. The method according to claim 12, wherein specific expression of the expression level, expression pattern, or both of the liver cancer prognostic marker is detected by Western blotting, enzyme linked immunosorbent assay (ELISA), radioimmunoassay, radioimmunodiffusion, Which is composed of Ouchterlony immunodiffusion method, rocket immunoelectrophoresis, tissue immuno staining, Immunoprecipitation Assay, Complement Fixation Assay, FACS, or protein chip A kit for predicting the prognosis of liver cancer. delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete delete

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