CA2419958A1 - Pyrrole-imines et pyrazole-imines fusionnees et substituees - Google Patents

Pyrrole-imines et pyrazole-imines fusionnees et substituees Download PDF

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Publication number
CA2419958A1
CA2419958A1 CA002419958A CA2419958A CA2419958A1 CA 2419958 A1 CA2419958 A1 CA 2419958A1 CA 002419958 A CA002419958 A CA 002419958A CA 2419958 A CA2419958 A CA 2419958A CA 2419958 A1 CA2419958 A1 CA 2419958A1
Authority
CA
Canada
Prior art keywords
alkyl
c6alkyl
substituted
alkoxy
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002419958A
Other languages
English (en)
Inventor
George Maynard
Linghong Xie
Stanislaw Rachwal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2419958A1 publication Critical patent/CA2419958A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

L'invention concerne des composés représentés par la formule (I) dans laquelle R, Ar, A, n, R¿1? et R¿2? sont tels que définis dans le descriptif. L'invention concerne également les sels pharmaceutiquement acceptables desdits composés. Ces composés sont des agonistes, des antagonistes ou des agonistes inverses hautement sélectifs pour les récepteurs cérébraux GABA¿A? ou des promédicaments d'agonistes, d'antagonistes ou d'agonistes inverses pour ces récepteurs. Ils sont donc utiles pour le diagnostic et le traitement de l'anxiété, de la dépression, du syndrome de Down, des troubles du sommeil et des troubles épileptiques, de la surdose de médicaments à la benzodiazépine et pour l'amélioration de la mémoire. L'invention concerne également des compositions pharmaceutiques, notamment des compositions pharmaceutiques conditionnées.
CA002419958A 2000-09-06 2001-09-06 Pyrrole-imines et pyrazole-imines fusionnees et substituees Abandoned CA2419958A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23049800P 2000-09-06 2000-09-06
US60/230,498 2000-09-06
PCT/US2001/027643 WO2002020480A1 (fr) 2000-09-06 2001-09-06 Pyrrole-imines et pyrazole-imines fusionnees et substituees

Publications (1)

Publication Number Publication Date
CA2419958A1 true CA2419958A1 (fr) 2002-03-14

Family

ID=22865462

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002419958A Abandoned CA2419958A1 (fr) 2000-09-06 2001-09-06 Pyrrole-imines et pyrazole-imines fusionnees et substituees

Country Status (8)

Country Link
US (2) US6743817B2 (fr)
EP (1) EP1326831A1 (fr)
JP (1) JP2004508352A (fr)
AU (1) AU2001290641A1 (fr)
BR (1) BR0113696A (fr)
CA (1) CA2419958A1 (fr)
MX (1) MXPA03001951A (fr)
WO (1) WO2002020480A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002020480A1 (fr) * 2000-09-06 2002-03-14 Neurogen Corporation Pyrrole-imines et pyrazole-imines fusionnees et substituees
CA2441926A1 (fr) 2001-03-27 2002-10-03 Neurogen Corporation (oxo-pyrazolo[1,5a]pyrimidin-2-yl)alkyl-carboxamides
US6852730B2 (en) 2002-02-07 2005-02-08 Neurogen Corporation Substituted fused pyrazolecarboxylic acid arylamides and related compounds
EP1732864B1 (fr) * 2004-03-18 2013-12-25 Suntory Holdings Limited Dérivé radiomarqué 3-[3-(benzoyl-amido)benzyloxy d'acide aspartique et procédé de préparation
MX2007010227A (es) 2005-02-25 2007-11-07 Serenex Inc Derivados de tetrahidroindolona y tetrahidroindazolona.
US20080070933A1 (en) * 2006-08-24 2008-03-20 Huang Kenneth H Purine, Pyrimidine, and Azaindole Derivatives
US20150374705A1 (en) 2012-02-14 2015-12-31 Shanghai Institues for Biological Sciences Substances for treatment or relief of pain
AR094263A1 (es) 2012-12-21 2015-07-22 Plexxikon Inc Compuestos moduladores selectivos de proteinquinasas

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5637725A (en) * 1995-06-05 1997-06-10 Neurogen Corporation Substituted aryl and cycloalkyl imidazolones; a new class of GABA brain receptor ligands
US5804686A (en) * 1996-01-19 1998-09-08 Neurogen Corporation fused pyrrolecarboxamides; a new class of GABA brain receptor ligands
GB9900222D0 (en) 1999-01-06 1999-02-24 Merck Sharp & Dohme Therapeutic compounds
EE200200111A (et) * 1999-08-31 2003-06-16 Neurogen Corporation Kondenseerunud pürroolkarboksamiidid: aju GABA-retseptori ligandid
WO2002020480A1 (fr) * 2000-09-06 2002-03-14 Neurogen Corporation Pyrrole-imines et pyrazole-imines fusionnees et substituees

Also Published As

Publication number Publication date
AU2001290641A1 (en) 2002-03-22
JP2004508352A (ja) 2004-03-18
US20050059826A1 (en) 2005-03-17
US6743817B2 (en) 2004-06-01
WO2002020480A1 (fr) 2002-03-14
BR0113696A (pt) 2003-07-22
MXPA03001951A (es) 2003-10-15
US20020128236A1 (en) 2002-09-12
EP1326831A1 (fr) 2003-07-16
US7282498B2 (en) 2007-10-16

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued