CA2416654A1 - Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers - Google Patents

Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers Download PDF

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Publication number
CA2416654A1
CA2416654A1 CA002416654A CA2416654A CA2416654A1 CA 2416654 A1 CA2416654 A1 CA 2416654A1 CA 002416654 A CA002416654 A CA 002416654A CA 2416654 A CA2416654 A CA 2416654A CA 2416654 A1 CA2416654 A1 CA 2416654A1
Authority
CA
Canada
Prior art keywords
substituted
group
phenyl
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002416654A
Other languages
English (en)
Inventor
Shao-Po Lu
R. Normand Hebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Lion Bioscience AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Bioscience AG filed Critical Lion Bioscience AG
Publication of CA2416654A1 publication Critical patent/CA2416654A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne de nouveaux composés dérivés d'hydantoïne bicycliques de formule (I) suivante : dans laquelle R?1¿ à R?5¿ et n sont tels que définis dans la description. L'invention concerne, en outre, des bibliothèques combinatoires contenant deux ou plusieurs de ces composés, ainsi que des procédés de préparation des composés dérivés d'hydantoïne bicycliques.
CA002416654A 2000-07-21 2001-07-18 Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers Abandoned CA2416654A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62117700A 2000-07-21 2000-07-21
US09/621,177 2000-07-21
PCT/EP2001/008322 WO2002008227A2 (fr) 2000-07-21 2001-07-18 Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers

Publications (1)

Publication Number Publication Date
CA2416654A1 true CA2416654A1 (fr) 2002-01-31

Family

ID=24489060

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002416654A Abandoned CA2416654A1 (fr) 2000-07-21 2001-07-18 Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers

Country Status (4)

Country Link
EP (1) EP1301512A2 (fr)
AU (1) AU2001281995A1 (fr)
CA (1) CA2416654A1 (fr)
WO (1) WO2002008227A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002227128A1 (en) 2000-12-01 2002-06-11 Bristol-Myers Squibb Company Hydantoin compounds useful as anti-inflammatory agents
US7199149B2 (en) 2003-10-01 2007-04-03 Bristol Myers Squibb Company Monocyclic and bicyclic lactams as factor Xa inhibitors
US7897785B2 (en) 2005-09-02 2011-03-01 Nippoh Chemicals Co., Ltd. 1,3-Diiodohydantoin compound and production method thereof
CA2689016C (fr) 2007-05-25 2014-08-12 Ipsen Pharma S.A.S. Ligands de recepteurs de la melanocortine modifies au moyen d'hydantoine
JP6470045B2 (ja) 2012-12-19 2019-02-13 日宝化学株式会社 ハロヒダントイン化合物の製造方法
WO2014097788A1 (fr) 2012-12-19 2014-06-26 日宝化学株式会社 Procédé et dispositif de production d'un composé d'halohydrantoïne, système réutilisable, et composé d'halohydrantoïne

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198423A (en) * 1979-03-20 1980-04-15 Basf Aktiengesellschaft 1,3-Bis-(trihalomethylsulfenyl)-imidazoline-2,4-diones
HUT62296A (en) * 1990-12-18 1993-04-28 Sandoz Ag Herbicidal composition comprising hydantoin derivative as active ingredient and process for producing the active ingredient
AU2115595A (en) * 1994-03-01 1995-09-18 Degussa A.G. Herbicidal bicyclic hydantoins
WO1997047626A1 (fr) * 1996-06-14 1997-12-18 Sagami Chemical Research Center Derives d'hydantoine bicycliques, produits intermediaires destines a leur fabrication, procede de preparation de ces derives et herbicides les contenant en qualite d'ingredient actif
AU4074297A (en) * 1996-08-26 1998-03-19 Eli Lilly And Company Combinatorial process for preparing substituted pyrrolidine libraries
JPH1087663A (ja) * 1996-09-12 1998-04-07 Sagami Chem Res Center 双環性ヒダントイン誘導体、それらの製造方法およびそれらを有効成分とする除草剤
US5859190A (en) * 1997-02-04 1999-01-12 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
ATE360818T1 (de) * 1999-06-15 2007-05-15 Aventis Pharma Inc Festphasensynthese von n,n-disubstituierten diazacycloalkylcarboxy-derivaten
KR100496940B1 (ko) * 1999-10-20 2005-06-23 다나베 세이야꾸 가부시키가이샤 αＬβ2 개재된 세포 접착 억제제

Also Published As

Publication number Publication date
AU2001281995A1 (en) 2002-02-05
EP1301512A2 (fr) 2003-04-16
WO2002008227A2 (fr) 2002-01-31
WO2002008227A3 (fr) 2002-08-29

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Legal Events

Date Code Title Description
FZDE Discontinued