EP1301512A2 - Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers - Google Patents

Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers

Info

Publication number
EP1301512A2
EP1301512A2 EP01960516A EP01960516A EP1301512A2 EP 1301512 A2 EP1301512 A2 EP 1301512A2 EP 01960516 A EP01960516 A EP 01960516A EP 01960516 A EP01960516 A EP 01960516A EP 1301512 A2 EP1301512 A2 EP 1301512A2
Authority
EP
European Patent Office
Prior art keywords
substituted
group
phenyl
formula
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01960516A
Other languages
German (de)
English (en)
Inventor
Shao-Po Lu
R. Normand Hebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sygnis Pharma AG
Original Assignee
Lion Bioscience AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Bioscience AG filed Critical Lion Bioscience AG
Publication of EP1301512A2 publication Critical patent/EP1301512A2/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures

Abstract

L'invention concerne de nouveaux composés dérivés d'hydantoïne bicycliques de formule (I) suivante : dans laquelle R1 à R5 et n sont tels que définis dans la description. L'invention concerne, en outre, des bibliothèques combinatoires contenant deux ou plusieurs de ces composés, ainsi que des procédés de préparation des composés dérivés d'hydantoïne bicycliques.
EP01960516A 2000-07-21 2001-07-18 Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers Withdrawn EP1301512A2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US621177 1996-03-21
US62117700A 2000-07-21 2000-07-21
PCT/EP2001/008322 WO2002008227A2 (fr) 2000-07-21 2001-07-18 Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers

Publications (1)

Publication Number Publication Date
EP1301512A2 true EP1301512A2 (fr) 2003-04-16

Family

ID=24489060

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01960516A Withdrawn EP1301512A2 (fr) 2000-07-21 2001-07-18 Derives d'hydantoine bicycliques et bibliotheques combinatoires de ces derniers

Country Status (4)

Country Link
EP (1) EP1301512A2 (fr)
AU (1) AU2001281995A1 (fr)
CA (1) CA2416654A1 (fr)
WO (1) WO2002008227A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044181A1 (fr) * 2000-12-01 2002-06-06 Bristol-Myers Squibb Company Composes d'hydantoine utiles en tant qu'agents anti-inflammatoires
US7199149B2 (en) 2003-10-01 2007-04-03 Bristol Myers Squibb Company Monocyclic and bicyclic lactams as factor Xa inhibitors
WO2007026766A1 (fr) * 2005-09-02 2007-03-08 Nippoh Chemicals Co., Ltd. Compose 1,3-diiodohydantoine et son procede de fabrication
US8563000B2 (en) 2007-05-25 2013-10-22 Ipsen Pharma S.A.S. Melanocortin receptor ligands modified with hydantoin
JP6470045B2 (ja) 2012-12-19 2019-02-13 日宝化学株式会社 ハロヒダントイン化合物の製造方法
WO2014097788A1 (fr) 2012-12-19 2014-06-26 日宝化学株式会社 Procédé et dispositif de production d'un composé d'halohydrantoïne, système réutilisable, et composé d'halohydrantoïne

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4198423A (en) * 1979-03-20 1980-04-15 Basf Aktiengesellschaft 1,3-Bis-(trihalomethylsulfenyl)-imidazoline-2,4-diones
HUT62296A (en) * 1990-12-18 1993-04-28 Sandoz Ag Herbicidal composition comprising hydantoin derivative as active ingredient and process for producing the active ingredient
WO1995023509A1 (fr) * 1994-03-01 1995-09-08 E.I. Du Pont De Nemours And Company Hydantoïnes bicycliques herbicides
AU3106997A (en) * 1996-06-14 1998-01-07 Kaken Pharmaceutical Co., Ltd. Bicyclic hydantoin derivatives, intermediates for the preparation thereof, process for the preparation of them, and herbicides containing the same as active ingredient
WO1998008813A1 (fr) * 1996-08-26 1998-03-05 Eli Lilly And Company Procede combinatoire de preparation d'echantillotheques de pyrrolidine substituee
JPH1087663A (ja) * 1996-09-12 1998-04-07 Sagami Chem Res Center 双環性ヒダントイン誘導体、それらの製造方法およびそれらを有効成分とする除草剤
US5859190A (en) * 1997-02-04 1999-01-12 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
WO2000077519A1 (fr) * 1999-06-15 2000-12-21 Aventis Pharmaceuticals Products Inc. Synthese en phase solide de derives de diazacycloalkylcarboxy n,n-disubstitues
WO2001030781A2 (fr) * 1999-10-20 2001-05-03 Tanabe Seiyaku Co., Ltd. Inhibiteurs d'adhesion cellulaire induite par alphalbeta¿2?

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0208227A3 *

Also Published As

Publication number Publication date
CA2416654A1 (fr) 2002-01-31
WO2002008227A3 (fr) 2002-08-29
AU2001281995A1 (en) 2002-02-05
WO2002008227A2 (fr) 2002-01-31

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20021220

AK Designated contracting states

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: HEBERT, R., NORMAND

Inventor name: LU, SHAO-PO

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: LION BIOSCIENCE AG

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20050201