CA2409614A1 - Separation of the enantiomers of piperidone derivatives with simultaneous racemisation in situ of the unwanted enantiomer - Google Patents
Separation of the enantiomers of piperidone derivatives with simultaneous racemisation in situ of the unwanted enantiomer Download PDFInfo
- Publication number
- CA2409614A1 CA2409614A1 CA002409614A CA2409614A CA2409614A1 CA 2409614 A1 CA2409614 A1 CA 2409614A1 CA 002409614 A CA002409614 A CA 002409614A CA 2409614 A CA2409614 A CA 2409614A CA 2409614 A1 CA2409614 A1 CA 2409614A1
- Authority
- CA
- Canada
- Prior art keywords
- enantiomers
- simultaneous
- racemisation
- situ
- separation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(CC(C)(C)*)CC(*)(*)C(CCN)=O Chemical compound CC(CC(C)(C)*)CC(*)(*)C(CCN)=O 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The invention relates to a process which can be used on an industrial scale for dynamically separating the enantiomers of piperidone derivatives of general formula (1) (see formula 1) wherein R1, R2, R3 and n may have the meanings given in the specification and claims, with simultaneous in situ racemisation of the unreacted enantiomer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10029851A DE10029851A1 (en) | 2000-06-16 | 2000-06-16 | Optical resolution of 2-substituted 4-piperidone derivatives, for use as pharmaceutical intermediates, by simultaneous formation of salt with optically active acid and racemization |
DE10029851.6 | 2000-06-16 | ||
PCT/EP2001/006552 WO2001096306A1 (en) | 2000-06-16 | 2001-06-09 | Enantiomer separation of piperidone derivatives with simultaneous in situ racemization of the unwanted enantiomer |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2409614A1 true CA2409614A1 (en) | 2001-12-20 |
CA2409614C CA2409614C (en) | 2008-08-05 |
Family
ID=7646064
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA 2409614 Expired - Fee Related CA2409614C (en) | 2000-06-16 | 2001-06-09 | Separation of the enantiomers of piperidone derivatives with simultaneous racemisation in situ of the unwanted enantiomer |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1305287A1 (en) |
JP (1) | JP2004503539A (en) |
KR (1) | KR100863922B1 (en) |
AR (1) | AR028957A1 (en) |
AU (1) | AU2001270563A1 (en) |
CA (1) | CA2409614C (en) |
DE (1) | DE10029851A1 (en) |
IL (2) | IL153085A0 (en) |
MX (1) | MXPA02012301A (en) |
WO (1) | WO2001096306A1 (en) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0736724B2 (en) * | 1992-08-07 | 1995-04-26 | 株式会社スリオンテック | Seeding and raising seedling sheet using ultraviolet curing adhesive and method for producing the same |
CA2200490C (en) * | 1994-09-23 | 2007-01-09 | Chiroscience Limited | Racemisation and asymmetric transformation processes used in the manufacture of levobupivacaine and analogues thereof |
DE19528472A1 (en) * | 1995-08-03 | 1997-02-06 | Boehringer Ingelheim Kg | New process for the production of norbenzomorphan of an intermediate stage in the production of pharmaceutically valuable benzomorphan derivatives, in particular of (-) - (1R, 5S, S "R) -3'-hydroxy-2- (2-methoxypropyl -) - 5.9.9 -trimethyl-6.7 benzomorphan |
-
2000
- 2000-06-16 DE DE10029851A patent/DE10029851A1/en not_active Ceased
-
2001
- 2001-06-09 CA CA 2409614 patent/CA2409614C/en not_active Expired - Fee Related
- 2001-06-09 AU AU2001270563A patent/AU2001270563A1/en not_active Abandoned
- 2001-06-09 WO PCT/EP2001/006552 patent/WO2001096306A1/en active Application Filing
- 2001-06-09 KR KR1020027016915A patent/KR100863922B1/en not_active IP Right Cessation
- 2001-06-09 MX MXPA02012301A patent/MXPA02012301A/en active IP Right Grant
- 2001-06-09 JP JP2002510449A patent/JP2004503539A/en active Pending
- 2001-06-09 EP EP01949395A patent/EP1305287A1/en not_active Withdrawn
- 2001-06-09 IL IL15308501A patent/IL153085A0/en active IP Right Grant
- 2001-06-15 AR ARP010102869A patent/AR028957A1/en not_active Suspension/Interruption
-
2002
- 2002-11-26 IL IL153085A patent/IL153085A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
CA2409614C (en) | 2008-08-05 |
MXPA02012301A (en) | 2003-04-25 |
DE10029851A1 (en) | 2001-12-20 |
IL153085A (en) | 2008-11-26 |
AU2001270563A1 (en) | 2001-12-24 |
IL153085A0 (en) | 2003-06-24 |
KR20030016288A (en) | 2003-02-26 |
AR028957A1 (en) | 2003-05-28 |
EP1305287A1 (en) | 2003-05-02 |
JP2004503539A (en) | 2004-02-05 |
WO2001096306A1 (en) | 2001-12-20 |
KR100863922B1 (en) | 2008-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |