CA2402798A1 - Faims apparatus and method with ion diverting device - Google Patents

Faims apparatus and method with ion diverting device Download PDF

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Publication number
CA2402798A1
CA2402798A1 CA002402798A CA2402798A CA2402798A1 CA 2402798 A1 CA2402798 A1 CA 2402798A1 CA 002402798 A CA002402798 A CA 002402798A CA 2402798 A CA2402798 A CA 2402798A CA 2402798 A1 CA2402798 A1 CA 2402798A1
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Canada
Prior art keywords
ion
diverter
ions
flow path
diverting
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Granted
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CA002402798A
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French (fr)
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CA2402798C (en
Inventor
Roger Guevremont
Randy Purves
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National Research Council of Canada
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Individual
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Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]

Abstract

A method and apparatus for selectively transmitting ions using a FAIMS
analyzer is disclosed. An ion diverter is included within the FAIMS analyzer for afffecting the trajectories of ions after separation to direct the ions in a known fashion. The ion diverter is optionally a gas flow source or an electrode for generating an electrical field to alter ion flow.

Claims (35)

1. An apparatus for separating ions, comprising:

a high f eld asymmetric waveform ion mobility spectrometer including:

two electrodes at least one of which is for receiving an asymmetric waveform electrical signal and for producing a field between the electrodes;

an ion inlet;

an analyzer region in communication with the ion inlet and defined by at least a first ion flow path between the two electrodes; and, an ion diverter separate from the two electrodes for diverting the ions from the ion flow path in a known fashion.
2. An apparatus according to claim 1, comprising an inlet for introducing a flow of a carrier gas into the analyser region.
3. An apparatus according to claim 2, wherein the ion diverter comprises a diverter for receiving an electrical signal and for producing an electric field for diverting the ions relative to the ion flow path absent the ion diverter in a known fashion as the ions exit from between the two electrodes.
4. An apparatus according to claim 3, wherein the ion diverter is disposed approximately between the at least a first ion flow path and a second other ion flow path.
5. An apparatus according to claim 4, wherein the two electrodes are concentric coaxially aligned generally cylindrical inner and outer electrode bodies forming an annular space therebetween, such that the at least a first ion flow path and the second other ion flow path are on opposing sides of the inner electrode.
6. An apparatus according to claim 4, wherein the inner electrode is provided with a terminus shaped for directing ions generally radially inward toward the central axis of the inner electrode.
7. An apparatus according to claim 6, wherein the outer surface of the ion diverter is along an approximately continuous curve with the outer surface of the inner electrode over a region of the terminus of the inner electrode.
8. An apparatus according to claim 7, comprising an annular space between the ion diverter and the inner electrode for providing a flow of a diverting gas for diverting the ions within the ion flow path in a known fashion as the ions exit from between the two electrodes.
9. An apparatus according to claim 3, wherein the diverter and at least a second other diverter are disposed on opposing sides of the at least a first ion flow path.
10. An apparatus according to claim 2, wherein the ion diverter is a port for providing a gas flow for diverting the ions relative to the ion flow path absent the ion diverter in a known fashion.
11. An apparatus according to claim 10, wherein the ion diverter is disposed approximately between the at least a first ion flow path and a second other ion flow path.
12. An apparatus according to claim 10, wherein the ion diverter includes a second other ion diverter and wherein the ion diverters are disposed on opposing sides of the at least a first ion flow path.
13. A method for separating ions comprising the steps of:

a) providing an asymmetric waveform and a direct-current compensation voltage to an electrode to form an analyzer electric field, the field for effecting a difference in net displacement between ions in a time of one cycle of the applied asymmetric waveform for effecting a first separation of the ions by forming a subset thereof;

b) producing ions within an ionization source;

c) transporting said produced ions through the electric field along at least a first ion flow path in a direction approximately transverse to the electric field;
and, d) diverting the selectively transmitted ions relative to the ion flow path as it would be absent the step of diverting in a predetermined fashion after separation.
14. A method according to claim 13, wherein the step of transporting includes the step of: providing a flow of a carrier gas for transporting said produced ions through the electric field along at least a first ion flow path.
15. A method according to claim 13, wherein the step of diverting the ions comprises the step of:

providing an electrical signal to a diverter electrode for producing a diverter electric field for diverting the selectively transmitted ions in a known fashion as the ions exit from the analyzer electric field.
16. A method according to claim 15, comprising the step of providing an annular space between the diverter electrode and the inner electrode for providing a flow of a gas for diverting the ions relative to the average ion flow path absent the ion diverter.
17. A method according to claim 15, wherein the selectively transmitted ions are diverted from the ion flow path such that the ions are attracted to a terminus of the diverter electrode to collide therewith.
18. A method according to claim 17, wherein the first ion diverter includes an ion detector for detecting at least an ion current.
19. A method according to claim 15, wherein the selectively transmitted ions are diverted such that the ions are directed generally toward an outlet to pass therethrough.
20. A method according to claim 15, wherein the first ion diverter is disposed approximately between the first ion flow path and a second other ion flow path.
21. A method according to claim 15, wherein the ion diverter includes two diverters electrodes disposed on opposing sides of the ion flow path.
22. A method according to claim 21, wherein the selectively transmitted ions are diverted such that a first species of ion is attracted to a terminus of the diverter electrode to collide therewith and a second other species of ion is attracted to a terminus of a second other diverter electrode to collide therewith.
23. A method according to claim 22, wherein the diverter electrodes each includes an ion detector for detecting at least an ion current.
24. A method according to claim 21, comprising the step of providing at least an electric signal to each of the diverter electrodes for displacing the selectively transmitted ions away from the diverter electrodes.
25. A method according to claim 24, wherein the ions are displaced toward an outlet orifice in communication with a low pressure region of a mass spectrometer.
26. A method according to claim 13, wherein the step of diverting comprises a step of providing a diverter gas flow for diverting the selectively transmitted ions relative to an average ion flow path absent the diverter gas flow in a known fashion.
27. A method according to claim 26, wherein the diverter gas flow is a flow of an inert gas for directing the selectively transmitted ions in a direction of the gas flow.
28. A method according to claim 27, wherein the ion diverter includes an ion detector for detecting at least an ion current.
29. A method according to claim 27, wherein the selectively transmitted ions are diverted such that the ions are directed generally toward an ion outlet to pass therethrough.
30. A method according to claim 26, wherein the diverter gas flow includes a flow of a reactive gas.
31. A method according to claim 30, wherein the reactive gas is selected to form at least a complex with at least some of the selectively transmitted ions within the ion flow path for effecting a second different separation of the ions.
32. A method according to claim 30, wherein the reactive gas includes at least an ionic species reactive with at least an ionic species of the selectively transmitted ions.
33. A method according to claim 32, wherein the at least an ionic species reactive with at least an ionic species of the selectively transmitted ions forms a neutral compound therewith.
34. A method according to claim 32, wherein the at least an ionic species reactive with at least an ionic species of the selectively transmitted ions forms at least a third different ionic species.
35. A method according to claim 26, wherein the diverter gas flow includes a flow of an inert gas.
CA2402798A 2000-03-14 2001-03-14 Faims apparatus and method with ion diverting device Expired - Fee Related CA2402798C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18908500P 2000-03-14 2000-03-14
US60/189,085 2000-03-14
PCT/CA2001/000309 WO2001069217A2 (en) 2000-03-14 2001-03-14 Faims apparatus and method with ion diverting device

Publications (2)

Publication Number Publication Date
CA2402798A1 true CA2402798A1 (en) 2001-09-20
CA2402798C CA2402798C (en) 2010-04-27

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Family Applications (6)

Application Number Title Priority Date Filing Date
CA2402798A Expired - Fee Related CA2402798C (en) 2000-03-14 2001-03-14 Faims apparatus and method with ion diverting device
CA2401802A Expired - Fee Related CA2401802C (en) 2000-03-14 2001-03-14 Tandem high field asymmetric waveform ion mobility spectrometry (faims)/tandem mass spectrometry
CA002401722A Expired - Fee Related CA2401722C (en) 2000-03-14 2001-03-14 Faims apparatus and method with laser-based ionization source
CA002402628A Abandoned CA2402628A1 (en) 2000-03-14 2001-03-14 Apparatus and method for trandem icp/faims/ms
CA002401735A Expired - Lifetime CA2401735C (en) 2000-03-14 2001-03-14 Faims apparatus and method using carrier gas of mixed composition
CA2402812A Expired - Fee Related CA2402812C (en) 2000-03-14 2001-03-14 Tandem faims/ion-trapping apparatus and method

Family Applications After (5)

Application Number Title Priority Date Filing Date
CA2401802A Expired - Fee Related CA2401802C (en) 2000-03-14 2001-03-14 Tandem high field asymmetric waveform ion mobility spectrometry (faims)/tandem mass spectrometry
CA002401722A Expired - Fee Related CA2401722C (en) 2000-03-14 2001-03-14 Faims apparatus and method with laser-based ionization source
CA002402628A Abandoned CA2402628A1 (en) 2000-03-14 2001-03-14 Apparatus and method for trandem icp/faims/ms
CA002401735A Expired - Lifetime CA2401735C (en) 2000-03-14 2001-03-14 Faims apparatus and method using carrier gas of mixed composition
CA2402812A Expired - Fee Related CA2402812C (en) 2000-03-14 2001-03-14 Tandem faims/ion-trapping apparatus and method

Country Status (8)

Country Link
US (6) US6653627B2 (en)
EP (4) EP1266395A2 (en)
JP (1) JP4783533B2 (en)
AT (2) ATE308115T1 (en)
AU (10) AU3907301A (en)
CA (6) CA2402798C (en)
DE (2) DE60114394T2 (en)
WO (6) WO2001069646A2 (en)

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