CA2402268C - Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections - Google Patents

Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections Download PDF

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Publication number
CA2402268C
CA2402268C CA2402268A CA2402268A CA2402268C CA 2402268 C CA2402268 C CA 2402268C CA 2402268 A CA2402268 A CA 2402268A CA 2402268 A CA2402268 A CA 2402268A CA 2402268 C CA2402268 C CA 2402268C
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CA
Canada
Prior art keywords
iss
virus
infection
respiratory
polynucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2402268A
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English (en)
French (fr)
Other versions
CA2402268A1 (en
Inventor
Gary Van Nest
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dynavax Technologies Corp
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Dynavax Technologies Corp
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Filing date
Publication date
Application filed by Dynavax Technologies Corp filed Critical Dynavax Technologies Corp
Publication of CA2402268A1 publication Critical patent/CA2402268A1/en
Application granted granted Critical
Publication of CA2402268C publication Critical patent/CA2402268C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2402268A 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections Expired - Fee Related CA2402268C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18858300P 2000-03-10 2000-03-10
US60/188,583 2000-03-10
US09/802,686 US20010046967A1 (en) 2000-03-10 2001-03-09 Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide
US09/802,686 2001-03-09
PCT/US2001/007839 WO2001068116A2 (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections

Publications (2)

Publication Number Publication Date
CA2402268A1 CA2402268A1 (en) 2001-09-20
CA2402268C true CA2402268C (en) 2012-10-02

Family

ID=26884244

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2402268A Expired - Fee Related CA2402268C (en) 2000-03-10 2001-03-12 Immunostimulatory polynucleotide sequences for use in preventing and treating respiratory viral infections

Country Status (8)

Country Link
US (3) US20010046967A1 (https=)
EP (1) EP1261352B1 (https=)
JP (1) JP2003526672A (https=)
AT (1) ATE476983T1 (https=)
AU (2) AU4358701A (https=)
CA (1) CA2402268C (https=)
DE (1) DE60142775D1 (https=)
WO (1) WO2001068116A2 (https=)

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US8466116B2 (en) 2001-12-20 2013-06-18 The Unites States Of America As Represented By The Secretary Of The Department Of Health And Human Services Use of CpG oligodeoxynucleotides to induce epithelial cell growth
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US8263091B2 (en) 2002-09-18 2012-09-11 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating and preventing infections in immunocompromised subjects with immunostimulatory CpG oligonucleotides
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US8158768B2 (en) 2002-12-23 2012-04-17 Dynavax Technologies Corporation Immunostimulatory sequence oligonucleotides and methods of using the same
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US20080027006A1 (en) * 2004-02-12 2008-01-31 The Regents Of The University Of Colorado Compositions And Methods For Modification And Prevention Of Sars Coronavirus Infectivity
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US8815817B2 (en) * 2008-05-15 2014-08-26 Dynavax Technologies Corporation Long term disease modification using immunostimulatory oligonucleotides
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Also Published As

Publication number Publication date
CA2402268A1 (en) 2001-09-20
AU2001243587C1 (en) 2006-11-16
DE60142775D1 (de) 2010-09-23
AU2001243587B2 (en) 2005-11-24
JP2003526672A (ja) 2003-09-09
US20010046967A1 (en) 2001-11-29
EP1261352A2 (en) 2002-12-04
WO2001068116A3 (en) 2002-08-08
ATE476983T1 (de) 2010-08-15
AU4358701A (en) 2001-09-24
WO2001068116A2 (en) 2001-09-20
US8226957B2 (en) 2012-07-24
US20100035975A1 (en) 2010-02-11
US20040009942A1 (en) 2004-01-15
EP1261352B1 (en) 2010-08-11

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