CA2402223A1 - Production directe de desacetylcephalosporine c - Google Patents

Production directe de desacetylcephalosporine c Download PDF

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Publication number
CA2402223A1
CA2402223A1 CA002402223A CA2402223A CA2402223A1 CA 2402223 A1 CA2402223 A1 CA 2402223A1 CA 002402223 A CA002402223 A CA 002402223A CA 2402223 A CA2402223 A CA 2402223A CA 2402223 A1 CA2402223 A1 CA 2402223A1
Authority
CA
Canada
Prior art keywords
cephalosporin
dna
esterase
desacetylcephalosporin
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002402223A
Other languages
English (en)
Inventor
Shu-Jen David Chiang
Jonathan David Basch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2402223A1 publication Critical patent/CA2402223A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/06—Cephalosporin C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

La présente invention concerne la production directe de désacétylcéphalosporine C par culture d'une souche d'Acremonium chrysogenum contenant des acides nucléiques de recombinaison codant pour la céphalosporine estérase de Rhodosporidium toruloides.
CA002402223A 2000-03-09 2001-03-08 Production directe de desacetylcephalosporine c Abandoned CA2402223A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18803300P 2000-03-09 2000-03-09
US60/188,033 2000-03-09
PCT/US2001/007417 WO2001066767A2 (fr) 2000-03-09 2001-03-08 Production directe de desacetylcephalosporine c

Publications (1)

Publication Number Publication Date
CA2402223A1 true CA2402223A1 (fr) 2001-09-13

Family

ID=22691506

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002402223A Abandoned CA2402223A1 (fr) 2000-03-09 2001-03-08 Production directe de desacetylcephalosporine c

Country Status (6)

Country Link
US (1) US20020048781A1 (fr)
EP (1) EP1263969A2 (fr)
JP (1) JP2004500826A (fr)
AU (1) AU2001240112A1 (fr)
CA (1) CA2402223A1 (fr)
WO (1) WO2001066767A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20071951A1 (it) 2007-10-09 2008-01-08 Acs Dobfar Spa Processo per la produzione di 7-metossi-3-desacetilcefalotina
CN105219830B (zh) * 2014-06-12 2020-06-16 上海医药工业研究院 一种头孢霉素c的制备方法及其所用的基因工程菌
CN111793075A (zh) * 2020-07-10 2020-10-20 伊犁川宁生物技术有限公司 一种高纯度3-去乙酰基头孢菌素c钠盐的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8005266L (sv) * 1979-07-19 1981-01-20 Glaxo Group Ltd Framstellning av en cefalosporin genom jesning
JPH04144688A (ja) * 1990-10-08 1992-05-19 Asahi Chem Ind Co Ltd 新規ｄｎａ化合物
WO1998012345A1 (fr) * 1996-09-18 1998-03-26 Bristol-Myers Squibb Company GENE DE LA CEPHALOSPORINE ESTERASETIRE DE $i(RHODOSPORIDIUM TORULOIDES)

Also Published As

Publication number Publication date
EP1263969A2 (fr) 2002-12-11
JP2004500826A (ja) 2004-01-15
WO2001066767A3 (fr) 2002-01-03
US20020048781A1 (en) 2002-04-25
AU2001240112A1 (en) 2001-09-17
WO2001066767A2 (fr) 2001-09-13

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Legal Events

Date Code Title Description
FZDE Discontinued