CA2399566A1 - Peptides et polypeptides de par4 - Google Patents

Peptides et polypeptides de par4 Download PDF

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Publication number
CA2399566A1
CA2399566A1 CA002399566A CA2399566A CA2399566A1 CA 2399566 A1 CA2399566 A1 CA 2399566A1 CA 002399566 A CA002399566 A CA 002399566A CA 2399566 A CA2399566 A CA 2399566A CA 2399566 A1 CA2399566 A1 CA 2399566A1
Authority
CA
Canada
Prior art keywords
gly
par4
pro
peptide
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002399566A
Other languages
English (en)
Inventor
Nand Baindur
Robert R. West
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of CA2399566A1 publication Critical patent/CA2399566A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Des membres de la famille du récepteur activé par protéase (PAR) induisent une signalisation cellulaire dans la réponse à des protéases. Ces récepteurs sont caractérisés par un ligand peptidique attaché au niveau de la terminaison amino-extracellulaire généré par une protéolyse mineure. Une analyse de structure-activité a révélé que des peptides et des polypeptides peuvent être conçus pour activer le PAR4 humain.
CA002399566A 2000-02-09 2001-02-06 Peptides et polypeptides de par4 Abandoned CA2399566A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50064600A 2000-02-09 2000-02-09
US09/500,646 2000-02-09
PCT/US2001/003807 WO2001058930A1 (fr) 2000-02-09 2001-02-06 Peptides et polypeptides de par4

Publications (1)

Publication Number Publication Date
CA2399566A1 true CA2399566A1 (fr) 2001-08-16

Family

ID=23990336

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002399566A Abandoned CA2399566A1 (fr) 2000-02-09 2001-02-06 Peptides et polypeptides de par4

Country Status (4)

Country Link
EP (1) EP1254160A1 (fr)
AU (1) AU2001233333A1 (fr)
CA (1) CA2399566A1 (fr)
WO (1) WO2001058930A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004080372A2 (fr) * 2003-03-11 2004-09-23 Bayer Healthcare Ag Diagnostic et traitement de maladies associees au recepteur 4 active par la proteinase et couple aux proteines g (par 4)
EP2841448A1 (fr) * 2012-04-26 2015-03-04 Bristol-Myers Squibb Company Peptides agonistes de par4

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010041418A (ko) * 1998-02-27 2001-05-15 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 프로테아제-활성화되는 수용체 4 및 그것의 사용
US6111075A (en) * 1998-04-01 2000-08-29 Zymogenetics, Inc. Protese-activated receptor PAR4 (ZCHEMR2)

Also Published As

Publication number Publication date
EP1254160A1 (fr) 2002-11-06
WO2001058930A1 (fr) 2001-08-16
AU2001233333A1 (en) 2001-08-20

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Legal Events

Date Code Title Description
FZDE Discontinued