CA2372805A1 - Variantes de l'autotaxine et leurs utilisations dans le traitement des troubles du metabolisme - Google Patents

Variantes de l'autotaxine et leurs utilisations dans le traitement des troubles du metabolisme Download PDF

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Publication number
CA2372805A1
CA2372805A1 CA002372805A CA2372805A CA2372805A1 CA 2372805 A1 CA2372805 A1 CA 2372805A1 CA 002372805 A CA002372805 A CA 002372805A CA 2372805 A CA2372805 A CA 2372805A CA 2372805 A1 CA2372805 A1 CA 2372805A1
Authority
CA
Canada
Prior art keywords
autotaxin
amino acid
seq
leu
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002372805A
Other languages
English (en)
Inventor
James D. Kelly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2372805A1 publication Critical patent/CA2372805A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Les altérations de la sensibilité insulinique sont associées au diabète et à des troubles tels que l'obésité et la dyslipidémie. Des niveaux élevés d'acide gras en circulation libre sous forme de triglycérides, qui constituent une facteur de risque important pour l'athérosclérose, viennent compliquer ces troubles. Les troubles du métabolisme tels que l'obésité, la dyslipidémie et le diabète peuvent être traités au moyen de compositions pharmaceutiques renfermant soit des polypeptides d'autotaxine ou des fragments fonctionnels de ces derniers, soit des molécules d'acides nucléiques codant pour lesdits polypeptides ou leurs fragments. Les polypeptides d'autotaxine convenant pour de telles méthodes thérapeutiques renferment par exemples de nouvelles formes d'autotaxine de l'homme et du rat.
CA002372805A 1999-05-07 2000-05-05 Variantes de l'autotaxine et leurs utilisations dans le traitement des troubles du metabolisme Abandoned CA2372805A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30697999A 1999-05-07 1999-05-07
US09/306,979 1999-05-07
PCT/US2000/012402 WO2000068386A1 (fr) 1999-05-07 2000-05-05 Variantes de l'autotaxine et leurs utilisations dans le traitement des troubles du metabolisme

Publications (1)

Publication Number Publication Date
CA2372805A1 true CA2372805A1 (fr) 2000-11-16

Family

ID=23187734

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002372805A Abandoned CA2372805A1 (fr) 1999-05-07 2000-05-05 Variantes de l'autotaxine et leurs utilisations dans le traitement des troubles du metabolisme

Country Status (7)

Country Link
EP (1) EP1177298A1 (fr)
JP (1) JP2002543789A (fr)
AU (1) AU4825000A (fr)
CA (1) CA2372805A1 (fr)
IL (1) IL146237A0 (fr)
NZ (1) NZ515193A (fr)
WO (1) WO2000068386A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040053893A1 (en) * 2000-12-28 2004-03-18 Tatsuya Kishimoto Method of assaying iysophospholipase d activity
US20050222070A1 (en) 2002-05-29 2005-10-06 Develogen Aktiengesellschaft Fuer Entwicklungsbiologische Forschung Pancreas-specific proteins
WO2003028543A2 (fr) * 2001-10-03 2003-04-10 Pfizer Products Inc. Molecules d'acide nucleique, polypeptides et utilisations associees comprenant le diagnostic et le traitement de la maladie d'alzheimer
WO2003031615A1 (fr) * 2001-10-04 2003-04-17 Apro Life Science Institute, Inc. Inhibiteur de l'acide lysophosphatidique synthase
EP1507553A2 (fr) * 2002-05-29 2005-02-23 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung Proteines specifiques du pancreas
CA2609208C (fr) 2005-06-10 2016-10-18 Per-Ake Albertsson Utilisation d'une membrane de cellule vegetale pour le traitement de l'obesite
CN101523213B (zh) * 2006-08-03 2017-03-08 国立大学法人东京大学 天然形式人自分泌运动因子特异的抗体、其筛选方法、以及通过测定自分泌运动因子而检测恶性淋巴瘤的方法和检测试剂
JP5864918B2 (ja) * 2011-07-06 2016-02-17 国立大学法人東北大学 オートタキシンアイソフォーム特異的抗体および検出方法
EP2825199A4 (fr) * 2012-03-15 2016-01-27 Janssen Biotech Inc Anticorps dirigés contre l'autotaxine humaine et procédés d'utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731167A (en) * 1992-01-17 1998-03-24 The United States Of America As Represented By The Department Of Health And Human Services Autotaxin: motility stimulating protein useful in cancer diagnosis and therapy

Also Published As

Publication number Publication date
AU4825000A (en) 2000-11-21
EP1177298A1 (fr) 2002-02-06
NZ515193A (en) 2003-05-30
IL146237A0 (en) 2002-07-25
JP2002543789A (ja) 2002-12-24
WO2000068386A1 (fr) 2000-11-16

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Legal Events

Date Code Title Description
FZDE Discontinued