CA2398929C - Neuroprotective, antithrombotic and anti-flammatory uses of activated protein c (apc) - Google Patents
Neuroprotective, antithrombotic and anti-flammatory uses of activated protein c (apc) Download PDFInfo
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- CA2398929C CA2398929C CA2398929A CA2398929A CA2398929C CA 2398929 C CA2398929 C CA 2398929C CA 2398929 A CA2398929 A CA 2398929A CA 2398929 A CA2398929 A CA 2398929A CA 2398929 C CA2398929 C CA 2398929C
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Classifications
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/49—Urokinase; Tissue plasminogen activator
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6464—Protein C (3.4.21.69)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Immunology (AREA)
- Biochemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
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- Psychiatry (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18022700P | 2000-02-04 | 2000-02-04 | |
| US60/180,227 | 2000-02-04 | ||
| PCT/US2001/003758 WO2001056532A2 (en) | 2000-02-04 | 2001-02-05 | Neuroprotective, antithrombotic and anti-inflammatory uses of activated protein c (apc) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2398929A1 CA2398929A1 (en) | 2001-08-09 |
| CA2398929C true CA2398929C (en) | 2011-05-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2398929A Expired - Fee Related CA2398929C (en) | 2000-02-04 | 2001-02-05 | Neuroprotective, antithrombotic and anti-flammatory uses of activated protein c (apc) |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7074402B2 (https=) |
| EP (1) | EP1255556B1 (https=) |
| JP (1) | JP2004508280A (https=) |
| AT (1) | ATE504310T1 (https=) |
| AU (1) | AU2001238034A1 (https=) |
| CA (1) | CA2398929C (https=) |
| DE (1) | DE60144366D1 (https=) |
| WO (1) | WO2001056532A2 (https=) |
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| US20040096443A1 (en) * | 2002-03-08 | 2004-05-20 | Traynelis Stephen Francis | Treatment of neurodegenerative diseases and conditions using par1 antagonists |
| JP4351041B2 (ja) | 2001-06-13 | 2009-10-28 | ザ・ユニバーシティ・オブ・シドニー | 傷治癒のための処置および組成物 |
| US20030073636A1 (en) * | 2001-09-19 | 2003-04-17 | Oklahoma Medical Research Foundation | Method of treating diabetes |
| WO2004030619A2 (en) | 2002-09-30 | 2004-04-15 | Socratech L.L.C. | Protein s protects the nervous system from injury |
| CA2508276C (en) * | 2002-12-05 | 2018-03-27 | Socratech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
| WO2004056309A2 (en) * | 2002-12-05 | 2004-07-08 | Socratech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
| US20070142272A1 (en) * | 2003-01-24 | 2007-06-21 | Zlokovic Berislav V | Neuroprotective activity of activated protein c independent of its anticoagulant activity |
| US9192657B2 (en) * | 2003-07-08 | 2015-11-24 | The Scripps Research Institute | Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity |
| JP2008507561A (ja) * | 2004-07-23 | 2008-03-13 | ザ ユニバーシティ オブ ロチェスター | 活性化プロテインｃによる、脳内のプラスミノゲン活性化因子の不都合な作用の阻害 |
| EP1841442A4 (en) * | 2005-01-07 | 2009-12-09 | Northern Sydney And Central Co | TREATMENT OF AUTOIMMUNE DISEASES AND INFLAMMATORY DISEASES |
| US7785857B2 (en) * | 2006-08-31 | 2010-08-31 | Saint Louis University | Protein C variant |
| EP2182978A4 (en) | 2007-07-20 | 2012-03-21 | Sanomune Inc | TISSUE KALLIKREIN FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID PROTEIN |
| US8257700B2 (en) * | 2008-02-05 | 2012-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Proteomic analysis of active multiple sclerosis lesions |
| CA2759490A1 (en) * | 2009-04-22 | 2010-10-28 | Sanomune Inc. | Tissue kallikrein for the treatment of huntington's disease |
| AU2013286812B2 (en) | 2012-07-04 | 2017-04-20 | Zz Biotech Llc | Treatment of inflammatory skin disorders |
| CN104122396A (zh) * | 2013-04-23 | 2014-10-29 | 中国科学院上海生命科学研究院 | 维生素k依赖性蛋白s作为糖尿病标志物的应用 |
| PL3131572T3 (pl) | 2014-04-16 | 2022-02-07 | Zz Biotech Llc | Analog apc do zastosowania w zaleczaniu rany |
| PT3137102T (pt) | 2014-04-16 | 2021-09-28 | Zz Biotech Llc | Apc para utilização no tratamento de cicatrização cutânea anormal |
| CN105806818B (zh) * | 2016-04-01 | 2019-11-22 | 南京医科大学 | 检测血小板nmda受体活性的方法及其应用 |
| EP3464322B1 (en) | 2016-06-05 | 2023-04-05 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Novel molecules for the treatment of inflammation |
| CN110446501A (zh) | 2017-03-09 | 2019-11-12 | 代阿麦迪卡股份有限公司 | 组织激肽释放酶1的剂型 |
| CA3176941A1 (en) * | 2020-03-24 | 2021-09-30 | Talengen International Limited | Method and medicine for treating huntington's disease |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084274A (en) * | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
| US5009889A (en) * | 1987-12-31 | 1991-04-23 | Oklahoma Medical Research Foundation | Treatment of dysfunctional vascular endothelium using activated protein C |
| US5254532A (en) * | 1989-06-26 | 1993-10-19 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Preparation for treating and preventing thromboses and thromboembolic complications, use of such a preparation and a method of producing the same |
| AT402153B (de) * | 1989-06-26 | 1997-02-25 | Immuno Ag | Protein-s-hältige pharmazeutische präparation |
| ID23176A (id) * | 1997-03-24 | 2000-03-23 | Lilly Co Eli | Metoda untuk mengobati gangguan pembuluh darah |
| WO1998055142A1 (en) * | 1997-06-05 | 1998-12-10 | Eli Lilly And Company | Methods for treating thrombotic disorders |
| HUP0001237A3 (en) * | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
-
2001
- 2001-02-05 WO PCT/US2001/003758 patent/WO2001056532A2/en not_active Ceased
- 2001-02-05 CA CA2398929A patent/CA2398929C/en not_active Expired - Fee Related
- 2001-02-05 US US09/777,484 patent/US7074402B2/en not_active Expired - Fee Related
- 2001-02-05 JP JP2001556226A patent/JP2004508280A/ja active Pending
- 2001-02-05 AT AT01910427T patent/ATE504310T1/de not_active IP Right Cessation
- 2001-02-05 EP EP01910427A patent/EP1255556B1/en not_active Expired - Lifetime
- 2001-02-05 DE DE60144366T patent/DE60144366D1/de not_active Expired - Lifetime
- 2001-02-05 AU AU2001238034A patent/AU2001238034A1/en not_active Abandoned
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|---|---|
| US20020028199A1 (en) | 2002-03-07 |
| DE60144366D1 (de) | 2011-05-19 |
| CA2398929A1 (en) | 2001-08-09 |
| EP1255556A4 (en) | 2003-07-02 |
| WO2001056532A2 (en) | 2001-08-09 |
| EP1255556A2 (en) | 2002-11-13 |
| WO2001056532A3 (en) | 2001-12-06 |
| ATE504310T1 (de) | 2011-04-15 |
| JP2004508280A (ja) | 2004-03-18 |
| WO2001056532A9 (en) | 2003-01-09 |
| AU2001238034A1 (en) | 2001-08-14 |
| EP1255556B1 (en) | 2011-04-06 |
| US7074402B2 (en) | 2006-07-11 |
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