CA2398808A1 - Molecules biocides, cibles macromoleculaires, et procedes de production et d'utilisation - Google Patents

Molecules biocides, cibles macromoleculaires, et procedes de production et d'utilisation Download PDF

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Publication number
CA2398808A1
CA2398808A1 CA002398808A CA2398808A CA2398808A1 CA 2398808 A1 CA2398808 A1 CA 2398808A1 CA 002398808 A CA002398808 A CA 002398808A CA 2398808 A CA2398808 A CA 2398808A CA 2398808 A1 CA2398808 A1 CA 2398808A1
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CA
Canada
Prior art keywords
peptide
seq
molecule
heat shock
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002398808A
Other languages
English (en)
Inventor
Laszlo Otvos
Magdalena Blaszczyk-Thurin
Mark Rogers
Sandor Lovas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Creighton University
Wistar Institute of Anatomy and Biology
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2398808A1 publication Critical patent/CA2398808A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne un procédé d'identification d'un composé présentant une activité biocide contre un organisme désigné. A cet effet, on recherche systématiquement parmi des molécules peptides et non peptides connues ou inconnues une molécule de test capable de liaison sélective à une séquence cible d'un couvercle de protéine de stress de l'organisme. La liaison du composé de test inhibe chez cette protéine l'activité de repliement de la protéine. L'un des modes de réalisation d'un tel procédé convient à l'identification ou la conception d'un composé biocide ou antibiotique pharmaceutique ou vétérinaire, de préférence d'un composé spécifique d'un pathogène et/ou d'une souche. A cet effet, le composé ne se lie pas à la protéine de choc qui est homologue du sujet mammalien à traiter avec le composé. Les procédés de recherche systématique peuvent comporter des procédures à liaison directe ou d'essais par compétition. Les molécules ou composés identifiés au moyen de ces procédés conviennent comme biocides à vocations notamment pharmaceutiques, vétérinaires, pesticides, insecticides et rodenticides.
CA002398808A 2000-01-21 2001-01-19 Molecules biocides, cibles macromoleculaires, et procedes de production et d'utilisation Abandoned CA2398808A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17756500P 2000-01-21 2000-01-21
US60/177,565 2000-01-21
US23759900P 2000-10-03 2000-10-03
US60/237,599 2000-10-03
PCT/US2001/001812 WO2001053509A2 (fr) 2000-01-21 2001-01-19 Molecules biocides, cibles macromoleculaires, et procedes de production et d'utilisation

Publications (1)

Publication Number Publication Date
CA2398808A1 true CA2398808A1 (fr) 2001-07-26

Family

ID=26873442

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002398808A Abandoned CA2398808A1 (fr) 2000-01-21 2001-01-19 Molecules biocides, cibles macromoleculaires, et procedes de production et d'utilisation

Country Status (4)

Country Link
EP (1) EP1252517A4 (fr)
AU (1) AU2795801A (fr)
CA (1) CA2398808A1 (fr)
WO (1) WO2001053509A2 (fr)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9200949D0 (en) * 1992-01-17 1992-03-11 Medical Res Council Diagnostic peptides
WO1994025616A1 (fr) * 1993-04-28 1994-11-10 Worcester Foundation For Experimental Biology Agents porogenes lytiques cibles sur des cellules
CA2176808A1 (fr) * 1993-11-18 1995-05-26 Scott Hultgren Composes et compositions pharmaceutiques de traitement et de prophylaxie d'infections bacteriennes
IT1282287B1 (it) * 1995-05-16 1998-03-16 Ist Superiore Sanita La sequenza del dna completo dell'inserto carlubo codificante per una proteina heat shch di forda (cansp 70) di candida albicans ceppo atcc
CN1192241A (zh) * 1995-06-07 1998-09-02 生化疫苗公司 Hsp70家族的链球菌热休克蛋白
US6503881B2 (en) * 1996-08-21 2003-01-07 Micrologix Biotech Inc. Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6462070B1 (en) * 1997-03-06 2002-10-08 The General Hospital Corporation Photosensitizer conjugates for pathogen targeting
AU769157B2 (en) * 1999-06-23 2004-01-15 Wistar Institute Of Anatomy And Biology, The Novel pyrrhocoricin-derived peptides, and methods of use thereof

Also Published As

Publication number Publication date
EP1252517A2 (fr) 2002-10-30
EP1252517A4 (fr) 2004-10-20
WO2001053509A2 (fr) 2001-07-26
WO2001053509A9 (fr) 2002-10-24
WO2001053509A3 (fr) 2001-12-20
AU2795801A (en) 2001-07-31

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