CA2397292A1 - Production de cellules - Google Patents

Production de cellules Download PDF

Info

Publication number
CA2397292A1
CA2397292A1 CA002397292A CA2397292A CA2397292A1 CA 2397292 A1 CA2397292 A1 CA 2397292A1 CA 002397292 A CA002397292 A CA 002397292A CA 2397292 A CA2397292 A CA 2397292A CA 2397292 A1 CA2397292 A1 CA 2397292A1
Authority
CA
Canada
Prior art keywords
cells
neurectoderm
cell
neural
differentiated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002397292A
Other languages
English (en)
Inventor
Peter David Rathjen
Joy Rathjen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viacyte Georgia Inc
Original Assignee
Bresagen Limited
Peter David Rathjen
Joy Rathjen
Bresagen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AUPQ5098A external-priority patent/AUPQ509800A0/en
Priority claimed from AUPQ7045A external-priority patent/AUPQ704500A0/en
Priority claimed from AUPQ7143A external-priority patent/AUPQ714300A0/en
Application filed by Bresagen Limited, Peter David Rathjen, Joy Rathjen, Bresagen Inc. filed Critical Bresagen Limited
Publication of CA2397292A1 publication Critical patent/CA2397292A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/14—Coculture with; Conditioned medium produced by hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
CA002397292A 2000-01-14 2001-01-12 Production de cellules Abandoned CA2397292A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
AUPQ5098A AUPQ509800A0 (en) 2000-01-14 2000-01-14 Cell production
AUPQ5098 2000-01-14
AUPQ7045 2000-04-20
AUPQ7045A AUPQ704500A0 (en) 2000-04-20 2000-04-20 Cell production
AUPQ7143 2000-04-27
AUPQ7143A AUPQ714300A0 (en) 2000-04-27 2000-04-27 Cell production
PCT/AU2001/000030 WO2001051611A1 (fr) 2000-01-14 2001-01-12 Production de cellules

Publications (1)

Publication Number Publication Date
CA2397292A1 true CA2397292A1 (fr) 2001-07-19

Family

ID=27158200

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002397292A Abandoned CA2397292A1 (fr) 2000-01-14 2001-01-12 Production de cellules

Country Status (3)

Country Link
EP (1) EP1254211A4 (fr)
CA (1) CA2397292A1 (fr)
WO (2) WO2001051611A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US10638734B2 (en) 2004-01-05 2020-05-05 Abt Holding Company Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US8252280B1 (en) 1999-08-05 2012-08-28 Regents Of The University Of Minnesota MAPC generation of muscle
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
IL157332A0 (en) 2001-02-14 2004-02-19 Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof
KR101089591B1 (ko) 2001-12-07 2011-12-05 제론 코포레이션 인간 배아 줄기세포 유래의 섬세포
US7799324B2 (en) 2001-12-07 2010-09-21 Geron Corporation Using undifferentiated embryonic stem cells to control the immune system
WO2003050251A2 (fr) 2001-12-07 2003-06-19 Geron Corporation Obtention de cellules hematopoietiques a partir de cellules souches embryonnaires humaines
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US20050101014A1 (en) 2002-07-11 2005-05-12 Keirstead Hans S. Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US7153650B2 (en) 2003-03-13 2006-12-26 Geron Corporation Marker system for preparing and characterizing high-quality human embryonic stem cells
US8426200B2 (en) 2003-07-02 2013-04-23 Regents Of The University Of Minnesota Neuronal differentiation of stem cells
EP2267116B1 (fr) 2004-07-13 2017-05-31 Asterias Biotherapeutics, Inc. Milieu de croissance pour cellules souches embryonnaires de primates
JP5560391B2 (ja) 2005-06-22 2014-07-23 アステリアス バイオセラピューティクス インコーポレイテッド ヒト胚性幹細胞の懸濁培養法
AU2006262329B2 (en) 2005-06-22 2011-04-07 Asterias Biotherapeutics, Inc. Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells
WO2007149182A2 (fr) 2006-06-19 2007-12-27 Geron Corporation Différenciation et enrichissement de cellules de type cellules des îlots pancréatiques à partir de cellules souches pluripotentes humaines
AU2007321928A1 (en) 2006-11-24 2008-05-29 Regents Of The University Of Minnesota Endodermal progenitor cells
KR101635750B1 (ko) 2008-01-30 2016-07-04 아스테리아스 바이오세라퓨틱스, 인크. 줄기 세포 유래 올리고덴드로사이트 전구 세포를 배양하기 위한 합성 표면
WO2009120891A2 (fr) 2008-03-27 2009-10-01 Geron Corporation Différenciation de cellules souches pluripotentes de primate en cellules de lignage hématopoïétique
GB0906424D0 (en) 2009-04-09 2009-05-20 Antoxis Ltd Use of compounds for differentiation of cells
WO2011091048A1 (fr) 2010-01-19 2011-07-28 The Board Of Trustees Of The Leland Stanford Junior University Conversion directe de cellules en cellules d'autres lignées
JP5926240B2 (ja) 2010-04-08 2016-05-25 ザ・ユニバーシティ・コート・オブ・ザ・ユニバーシティ・オブ・エディンバラＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｃｏｕｒｔ ｏｆ ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｅｄｉｎｂｕｒｇｈ 軟骨形成性始原細胞、細胞の派生のためのプロトコールおよびその使用
SI2561078T1 (sl) 2010-04-23 2019-01-31 Cold Spring Harbor Laboratory Nove strukturno oblikovane shRNA
GB201206773D0 (en) * 2012-04-17 2012-05-30 Cambridge Entpr Ltd Stem cells from the mammalian neural plate
RU2016100219A (ru) 2013-06-11 2017-07-17 Президент Энд Феллоус Оф Гарвард Колледж КЛЕТКИ SC-β И КОМПОЗИЦИИ, И СПОСОБЫ ДЛЯ ИХ СОЗДАНИЯ
KR20240004504A (ko) 2021-04-11 2024-01-11 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 심근세포 및 이를 생산하기 위한 조성물 및 방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2140884A1 (fr) * 1992-07-27 1994-02-03 David J. Anderson Cellules souches nerveuses mammaliennes pluripotentes
DE19756864C5 (de) * 1997-12-19 2014-07-10 Oliver Brüstle Neurale Vorläuferzellen, Verfahren zu ihrer Herstellung und ihre Verwendung zur Therapie von neuralen Defekten
EP1068295A4 (fr) * 1998-04-09 2002-08-21 Bresagen Ltd Facteur de differentiation/de proliferation et de conservation des cellules et procedes d'utilisation correspondants

Also Published As

Publication number Publication date
WO2001051610A1 (fr) 2001-07-19
WO2001051611A1 (fr) 2001-07-19
EP1254211A4 (fr) 2003-07-16
EP1254211A1 (fr) 2002-11-06

Similar Documents

Publication Publication Date Title
CA2397292A1 (fr) Production de cellules
Rathjen et al. Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population
US7211434B2 (en) Primitive neural stem cells and method for differentiation of stem cells to neural cells
JP5982286B2 (ja) 細胞の再プログラミングのための方法とその用途
KR100763477B1 (ko) 사람 배아 줄기세포로부터 최종적으로 분화된 도파민작용성 뉴런의 유도
AU755028B2 (en) Neural precursor cells, method for the production and use thereof in neural defect therapy
US8809052B2 (en) Methods of generating mature oligodendrocytes
KR20190039434A (ko) 만능 세포를 분화시키는 방법
JP4900587B2 (ja) ヒト胚幹細胞由来の最終分化ドーパミン作動性神経細胞の誘導
EP1523549A2 (fr) Oligodendrocytes derives de cellules souches embryonnaires humaines pour remyelinisation et traitement de lesion de la moelle epiniere
JP2010536357A (ja) 多能性幹細胞からのニューロン細胞の生成
Barald et al. Immortalized cell lines from embryonic avian and murine otocysts: tools for molecular studies of the developing inner ear
Osakada et al. Neural induction and patterning in Mammalian pluripotent stem cells
Zholudeva et al. Preparation of neural stem cells and progenitors: neuronal production and grafting applications
US20070020608A1 (en) Method for the generation of neural progenitor cells
WO2013012269A2 (fr) Procédé de production d'une cellule précurseur d'oligodendrocyte à partir d'une cellule souche pluripotente
Billon et al. Generation and characterization of oligodendrocytes from lineage-selectable embryonic stem cells in vitro
US20030134413A1 (en) Cell production
JP2023054306A (ja) 無担体３ｄ球体浮遊培養における網膜ニューロン生成のための方法および組成物
AU2654401A (en) Cell production
KR20050083106A (ko) 인간 배아줄기세포로부터 인간 신경전구세포주의 제조방법
CA3195622A1 (fr) Procedes de generation de cellules ciliees de l'oreille interne
Bertacchi In vitro neural differentiation of mouse embryonic stem cells: the positional identity of mouse ES-generated neurons is affected by BMP, Wnt and activin signaling
Lamba et al. Regenerative medicine for diseases of the retina
Apicella Embryonic stem cell-derived populations retain their tumorigenic potential

Legal Events

Date Code Title Description
FZDE Dead