CA2395094A1 - Derives peptidiques d'acryloyle, procede de preparation et leur utilisation en tant qu'agents antitumoraux - Google Patents

Derives peptidiques d'acryloyle, procede de preparation et leur utilisation en tant qu'agents antitumoraux Download PDF

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Publication number
CA2395094A1
CA2395094A1 CA002395094A CA2395094A CA2395094A1 CA 2395094 A1 CA2395094 A1 CA 2395094A1 CA 002395094 A CA002395094 A CA 002395094A CA 2395094 A CA2395094 A CA 2395094A CA 2395094 A1 CA2395094 A1 CA 2395094A1
Authority
CA
Canada
Prior art keywords
amino
methyl
carbonyl
pyrrol
pyrrole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002395094A
Other languages
English (en)
Inventor
Maria Cristina Rosa Geroni
Pier Giovanni Baraldi
Paolo Cozzi
Italo Beria
Romeo Romagnoli
Marina Caldarelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2395094A1 publication Critical patent/CA2395094A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Les composés de l'invention se présentent comme des dérivés peptidiques d'acryloyle de la formule (I) dans laquelle n est 3 ou 4; m est 0, 1 ou 2; X et Y sont identiques ou différents et sont sélectionnés, indépendamment de chaque noyau hétérocyclique, entre N ou CH; R(1) et R(2), identiques ou différents, sont sélectionnés entre hydrogène, halogène ou alkyle C(1)-C(4); R(3) est hydrogène ou halogène, B est sélectionnés parmi les groupes correspondant à la formule (II), dans laquelle R(4), R(5), R(7), et R(8) sont indépendamment les uns des autres hydrogène ou alkyle C(1)-C(4); R(6) est hydrogène, hydroxy ou alkyle C(1)-C(4); ou un sel pharmaceutiquement acceptable de ceux-ci; et ce à condition que X et Y ne sont pas tous deux des atomes N pour le même noyau hétérocyclique; lorsque X et Y sont des groupes CH et m est 0, au moins un des R(4), R(5), ou R(6) est différent d'hydrogène; lorsqu'au moins un des X et Y est autre que CH, au moins un parmi R(4) et R(5) est différent d'hydrogène. Les composés sont utilisés comme agents antitumoraux.
CA002395094A 1999-12-03 2000-11-23 Derives peptidiques d'acryloyle, procede de preparation et leur utilisation en tant qu'agents antitumoraux Abandoned CA2395094A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9928703.9A GB9928703D0 (en) 1999-12-03 1999-12-03 Acryloyl peptidic derivatives,process for their preparation and their use as antitumour agents
GB9928703.9 1999-12-03
PCT/EP2000/011714 WO2001040181A1 (fr) 1999-12-03 2000-11-23 Derives peptidiques d'acryloyle, procede de preparation et leur utilisation en tant qu'agents antitumoraux

Publications (1)

Publication Number Publication Date
CA2395094A1 true CA2395094A1 (fr) 2001-06-07

Family

ID=10865724

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002395094A Abandoned CA2395094A1 (fr) 1999-12-03 2000-11-23 Derives peptidiques d'acryloyle, procede de preparation et leur utilisation en tant qu'agents antitumoraux

Country Status (10)

Country Link
EP (1) EP1242374A1 (fr)
JP (1) JP2003515586A (fr)
KR (1) KR20020084069A (fr)
AU (1) AU781657B2 (fr)
BR (1) BR0016115A (fr)
CA (1) CA2395094A1 (fr)
GB (1) GB9928703D0 (fr)
NZ (1) NZ519581A (fr)
WO (1) WO2001040181A1 (fr)
ZA (1) ZA200204722B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0011059D0 (en) * 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015446D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites
GB0015447D0 (en) 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
GB0016447D0 (en) 2000-07-04 2000-08-23 Pharmacia & Upjohn Spa Process for preparing distamycin derivatives
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives
US6969592B2 (en) 2001-09-26 2005-11-29 Pharmacia Italia S.P.A. Method for predicting the sensitivity to chemotherapy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9416005D0 (en) * 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
GB9610079D0 (en) * 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9806689D0 (en) * 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents

Also Published As

Publication number Publication date
KR20020084069A (ko) 2002-11-04
EP1242374A1 (fr) 2002-09-25
AU781657B2 (en) 2005-06-02
NZ519581A (en) 2004-05-28
ZA200204722B (en) 2004-02-03
BR0016115A (pt) 2002-08-20
GB9928703D0 (en) 2000-02-02
AU2837001A (en) 2001-06-12
JP2003515586A (ja) 2003-05-07
WO2001040181A1 (fr) 2001-06-07

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