CA2393834A1 - Fragments de proteines de la famille wasp, et leurs utilisations - Google Patents

Info

Publication number

CA2393834A1

CA2393834A1 CA002393834A CA2393834A CA2393834A1 CA 2393834 A1 CA2393834 A1 CA 2393834A1 CA 002393834 A CA002393834 A CA 002393834A CA 2393834 A CA2393834 A CA 2393834A CA 2393834 A1 CA2393834 A1 CA 2393834A1

Authority

CA

Canada

Prior art keywords

ala

pro

ser

gly

gln

Prior art date

1999-12-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

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• 108090000623 proteins and genes Proteins 0.000 title claims abstract description 209
• 102000004169 proteins and genes Human genes 0.000 title claims abstract description 207
• 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 333
• 108010033276 Peptide Fragments Proteins 0.000 claims abstract description 107
• 102000007079 Peptide Fragments Human genes 0.000 claims abstract description 107
• 210000004292 cytoskeleton Anatomy 0.000 claims abstract description 40
• 238000000034 method Methods 0.000 claims abstract description 34
• 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 25
• 108010085238 Actins Proteins 0.000 claims abstract description 24
• 102000007469 Actins Human genes 0.000 claims abstract description 24
• 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 22
• 230000015572 biosynthetic process Effects 0.000 claims abstract description 19
• 238000012216 screening Methods 0.000 claims abstract description 18
• 230000002401 inhibitory effect Effects 0.000 claims abstract description 11
• 230000001413 cellular effect Effects 0.000 claims abstract description 9
• 230000004936 stimulating effect Effects 0.000 claims abstract 3
• 150000001413 amino acids Chemical class 0.000 claims description 178
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• 108010077112 prolyl-proline Proteins 0.000 claims description 121
• 108010000434 glycyl-alanyl-leucine Proteins 0.000 claims description 97
• PJYSOYLLTJKZHC-GUBZILKMSA-N Leu-Asp-Gln Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CCC(N)=O PJYSOYLLTJKZHC-GUBZILKMSA-N 0.000 claims description 74
• 108010038633 aspartylglutamate Proteins 0.000 claims description 59
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• 108010093296 prolyl-prolyl-alanine Proteins 0.000 claims description 58
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• VSVZIEVNUYDAFR-YUMQZZPRSA-N Gly-Ala-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)CN VSVZIEVNUYDAFR-YUMQZZPRSA-N 0.000 claims description 45
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• RCYUBVHMVUHEBM-RCWTZXSCSA-N Pro-Pro-Thr Chemical compound [H]N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(O)=O RCYUBVHMVUHEBM-RCWTZXSCSA-N 0.000 claims description 31
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• 125000001433 C-terminal amino-acid group Chemical group 0.000 claims description 29
• CLODWIOAKCSBAN-BQBZGAKWSA-N Gly-Arg-Asp Chemical compound NC(N)=NCCC[C@H](NC(=O)CN)C(=O)N[C@@H](CC(O)=O)C(O)=O CLODWIOAKCSBAN-BQBZGAKWSA-N 0.000 claims description 29
• BJWKOATWNQJPSK-SRVKXCTJSA-N Leu-Met-Glu Chemical compound CC(C)C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)O)N BJWKOATWNQJPSK-SRVKXCTJSA-N 0.000 claims description 29
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• 108010069020 alanyl-prolyl-glycine Proteins 0.000 claims description 29
• XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims description 29
• NMXKFWOEASXOGB-QSFUFRPTSA-N Ala-Ile-His Chemical compound C[C@H](N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](C(O)=O)CC1=CN=CN1 NMXKFWOEASXOGB-QSFUFRPTSA-N 0.000 claims description 28
• VIJMRAIWYWRXSR-CIUDSAMLSA-N His-Ser-Ser Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC1=CN=CN1 VIJMRAIWYWRXSR-CIUDSAMLSA-N 0.000 claims description 28
• NCVJJAJVWILAGI-SRVKXCTJSA-N Met-Gln-Lys Chemical compound CSCC[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)O)N NCVJJAJVWILAGI-SRVKXCTJSA-N 0.000 claims description 28
• 241001529936 Murinae Species 0.000 claims description 28
• KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 claims description 28
• 108010031719 prolyl-serine Proteins 0.000 claims description 28
• 108010062796 arginyllysine Proteins 0.000 claims description 27
• 108010073472 leucyl-prolyl-proline Proteins 0.000 claims description 27
• MIIVFRCYJABHTQ-ONGXEEELSA-N Gly-Leu-Val Chemical compound [H]NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(O)=O MIIVFRCYJABHTQ-ONGXEEELSA-N 0.000 claims description 26
• VCHVSKNMTXWIIP-SRVKXCTJSA-N Leu-Lys-Ser Chemical compound [H]N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O VCHVSKNMTXWIIP-SRVKXCTJSA-N 0.000 claims description 26
• KDBHVPXBQADZKY-GUBZILKMSA-N Pro-Pro-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCCC1 KDBHVPXBQADZKY-GUBZILKMSA-N 0.000 claims description 26
• GISFCCXBVJKGEO-QEJZJMRPSA-N Asp-Glu-Trp Chemical compound [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O GISFCCXBVJKGEO-QEJZJMRPSA-N 0.000 claims description 25
• 108010087924 alanylproline Proteins 0.000 claims description 25
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• WCFCYFDBMNFSPA-ACZMJKKPSA-N Asp-Asp-Glu Chemical compound OC(=O)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(O)=O)CCC(O)=O WCFCYFDBMNFSPA-ACZMJKKPSA-N 0.000 claims description 23
• 102000009652 Neuronal Wiskott-Aldrich Syndrome Protein Human genes 0.000 claims description 23
• CELJCNRXKZPTCX-XPUUQOCRSA-N Val-Gly-Ala Chemical compound CC(C)[C@H](N)C(=O)NCC(=O)N[C@@H](C)C(O)=O CELJCNRXKZPTCX-XPUUQOCRSA-N 0.000 claims description 23
• JPHYJQHPILOKHC-ACZMJKKPSA-N Glu-Asp-Asp Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(O)=O JPHYJQHPILOKHC-ACZMJKKPSA-N 0.000 claims description 22
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• 150000007513 acids Chemical class 0.000 claims description 22
• 108010055341 glutamyl-glutamic acid Proteins 0.000 claims description 22
• FFZJHQODAYHGPO-KZVJFYERSA-N Ala-Pro-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N FFZJHQODAYHGPO-KZVJFYERSA-N 0.000 claims description 21
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• 101000621420 Homo sapiens Neural Wiskott-Aldrich syndrome protein Proteins 0.000 claims description 21
• XMQZLGBUJMMODC-AVGNSLFASA-N Met-His-Val Chemical compound [H]N[C@@H](CCSC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(O)=O XMQZLGBUJMMODC-AVGNSLFASA-N 0.000 claims description 21
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• 102000001392 Wiskott Aldrich Syndrome protein Human genes 0.000 claims description 21
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• KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 claims description 21
• 102000056716 human WASL Human genes 0.000 claims description 21
• NFLFJGGKOHYZJF-BJDJZHNGSA-N Lys-Ala-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN NFLFJGGKOHYZJF-BJDJZHNGSA-N 0.000 claims description 20
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