CA2391129A1 - Transduction de cellules souches hematopoietiques par vecteur de lentivirus - Google Patents
Transduction de cellules souches hematopoietiques par vecteur de lentivirus Download PDFInfo
- Publication number
- CA2391129A1 CA2391129A1 CA002391129A CA2391129A CA2391129A1 CA 2391129 A1 CA2391129 A1 CA 2391129A1 CA 002391129 A CA002391129 A CA 002391129A CA 2391129 A CA2391129 A CA 2391129A CA 2391129 A1 CA2391129 A1 CA 2391129A1
- Authority
- CA
- Canada
- Prior art keywords
- vector
- hematopoietic stem
- cells
- stem cells
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16045—Special targeting system for viral vectors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des compositions et des procédés de préparation et d'utilisation de ces compositions en rapport avec la transduction de cellules souches hématopoïétiques. Elle concerne des vecteurs de lentivirus capables d'effectuer la transduction de populations purifiées de cellules souches hématopoïétiques. On peut mettre en application ces compositions et ces procédés afin de traiter des maladies présentant des troubles sanguins, telles que la drépanocytose ou la thalassémie.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16462599P | 1999-11-10 | 1999-11-10 | |
US60/164,625 | 1999-11-10 | ||
PCT/US2000/030882 WO2001034843A1 (fr) | 1999-11-10 | 2000-11-10 | Transduction de cellules souches hematopoietiques par vecteur de lentivirus |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2391129A1 true CA2391129A1 (fr) | 2001-05-17 |
Family
ID=22595350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002391129A Abandoned CA2391129A1 (fr) | 1999-11-10 | 2000-11-10 | Transduction de cellules souches hematopoietiques par vecteur de lentivirus |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1230394A4 (fr) |
JP (1) | JP2003517301A (fr) |
AU (1) | AU784988B2 (fr) |
CA (1) | CA2391129A1 (fr) |
WO (1) | WO2001034843A1 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7575924B2 (en) | 2000-11-13 | 2009-08-18 | Research Development Foundation | Methods and compositions relating to improved lentiviral vectors and their applications |
IL160132A0 (en) | 2001-08-02 | 2004-06-20 | Inst Clayton De La Rech | Methods and compositions relating to improved lentiviral vector production systems |
CA2915676C (fr) | 2001-10-02 | 2017-06-06 | Institut Clayton De La Recherche | Vecteurs lentiviraux a expression reduite |
US7566535B2 (en) | 2002-03-07 | 2009-07-28 | University Of Delaware | Enhanced oligonucleotide-mediated nucleic acid sequence alteration |
PL3214091T3 (pl) * | 2010-12-09 | 2019-03-29 | The Trustees Of The University Of Pennsylvania | Zastosowanie komórek T modyfikowanych chimerycznymi receptorami antygenowymi do leczenia nowotworów |
WO2012094193A2 (fr) * | 2011-01-03 | 2012-07-12 | Bluebird Bio, Inc. | Procédés pour améliorer l'administration de cellules transduites avec un gène |
TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
SG10202109752XA (en) | 2014-04-07 | 2021-10-28 | Novartis Ag | Treatment of cancer using anti-cd19 chimeric antigen receptor |
US10653123B2 (en) | 2014-05-27 | 2020-05-19 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for perturbing gene expression in hematopoietic stem cell lineages in vivo |
SG11201708191XA (en) | 2015-04-08 | 2017-11-29 | Novartis Ag | Cd20 therapies, cd22 therapies, and combination therapies with a cd19 chimeric antigen receptor (car) - expressing cell |
TWI650419B (zh) * | 2016-09-13 | 2019-02-11 | 中央研究院 | 藉移植增加壽命及/或治療細胞增殖疾病之方法 |
CN110225927B (zh) | 2016-10-07 | 2024-01-12 | 诺华股份有限公司 | 用于治疗癌症的嵌合抗原受体 |
WO2019009979A1 (fr) | 2017-07-06 | 2019-01-10 | The Medical College Of Wisconsin, Inc. | Nouvelle stratégie d'enrichissement in vitro et in vivo ciblant les lymphocytes dérivés de csh transduites par un vecteur pour la thérapie de troubles |
-
2000
- 2000-11-10 EP EP00978485A patent/EP1230394A4/fr not_active Withdrawn
- 2000-11-10 JP JP2001536768A patent/JP2003517301A/ja active Pending
- 2000-11-10 CA CA002391129A patent/CA2391129A1/fr not_active Abandoned
- 2000-11-10 WO PCT/US2000/030882 patent/WO2001034843A1/fr not_active Application Discontinuation
- 2000-11-10 AU AU15944/01A patent/AU784988B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1230394A4 (fr) | 2002-12-18 |
AU1594401A (en) | 2001-06-06 |
WO2001034843A1 (fr) | 2001-05-17 |
EP1230394A1 (fr) | 2002-08-14 |
JP2003517301A (ja) | 2003-05-27 |
AU784988B2 (en) | 2006-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Hanawa et al. | Efficient gene transfer into rhesus repopulating hematopoietic stem cells using a simian immunodeficiency virus–based lentiviral vector system | |
Moritz et al. | Human cord blood cells as targets for gene transfer: potential use in genetic therapies of severe combined immunodeficiency disease. | |
KR101990068B1 (ko) | 렌티바이러스 벡터의 안정한 제조 | |
US8501464B2 (en) | Lentiviral vectors carrying synthetic bi-directional promoters and uses thereof | |
EP2761010B1 (fr) | Vecteurs de lentivirus pseudotypés avec des glycoprotéines d'enveloppe de baev mutees | |
Vassilopoulos et al. | Gene transfer into murine hematopoietic stem cells with helper-free foamy virus vectors | |
Nagano et al. | Lentiviral vector transduction of male germ line stem cells in mice | |
US20090148425A1 (en) | Therapeutic method for blood coagulation disorder | |
US20200347404A1 (en) | Lentiviral vectors expressing foxp3 in hematopoietic stem cells to treat immune deficiencies and autoimmune diseases | |
AU784988B2 (en) | Lentiviral vector transduction of hematopoietic stem cells | |
Chen et al. | Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice | |
JP2018519827A (ja) | 逆配向のヒトユビキチンcプロモーターを含むレトロウイルスベクター | |
Tahara-Hanaoka et al. | Lentiviral vector–mediated transduction of murine CD34− hematopoietic stem cells | |
KR101891626B1 (ko) | 렌티바이러스 벡터의 반-안정성 산물 | |
Douglas et al. | Efficient human immunodeficiency virus-based vector transduction of unstimulated human mobilized peripheral blood CD34+ cells in the SCID-hu Thy/Liv model of human T cell lymphopoiesis | |
Liu et al. | Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34+ NOD/SCID-repopulating cells | |
Pan et al. | Prolonged adherence of human immunodeficiency virus-derived vector particles to hematopoietic target cells leads to secondary transduction in vitro and in vivo | |
WO2008136656A1 (fr) | Procédés perfectionnés et moyens pour l'administration de gènes lentiviraux | |
US20220378937A1 (en) | Lentiviral vectors in hematopoietic stem cells to treat x-linked chronic granulomatous disease | |
Derdouch et al. | Reconstitution of the myeloid and lymphoid compartments after the transplantation of autologous and genetically modified CD34+ bone marrow cells, following gamma irradiation in cynomolgus macaques | |
CA3219359A1 (fr) | Vecteurs lentiviraux et utilisations de ceux-ci | |
Mouly et al. | CD4 regulation in human lymphoid non-T-cells: a role for the silencer element | |
EP2021484B1 (fr) | Vecteurs d'expression comprenant le promoteur hs1 de l'oncogène vav1 et leurs utilisations pour la préparation de compositions pharmaceutiques destinées à une thérapie génique somatique |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Dead |