CA2389479A1 - Butyne diol derivatives - Google Patents
Butyne diol derivatives Download PDFInfo
- Publication number
- CA2389479A1 CA2389479A1 CA002389479A CA2389479A CA2389479A1 CA 2389479 A1 CA2389479 A1 CA 2389479A1 CA 002389479 A CA002389479 A CA 002389479A CA 2389479 A CA2389479 A CA 2389479A CA 2389479 A1 CA2389479 A1 CA 2389479A1
- Authority
- CA
- Canada
- Prior art keywords
- pyrimidinyl
- methoxyphenoxy
- butynyloxy
- hydroxy
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EPPCT/EP99/10276 | 1999-12-22 | ||
EP9910276 | 1999-12-22 | ||
PCT/EP2000/012743 WO2001046156A1 (en) | 1999-12-22 | 2000-12-14 | Butyne diol derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2389479A1 true CA2389479A1 (en) | 2001-06-28 |
Family
ID=8167542
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002389479A Abandoned CA2389479A1 (en) | 1999-12-22 | 2000-12-14 | Butyne diol derivatives |
Country Status (12)
Country | Link |
---|---|
JP (1) | JP2003518102A (zh) |
KR (1) | KR20020068373A (zh) |
CN (1) | CN1407973A (zh) |
AU (1) | AU3536701A (zh) |
BR (1) | BR0016241A (zh) |
CA (1) | CA2389479A1 (zh) |
HU (1) | HUP0204168A2 (zh) |
IL (1) | IL149529A0 (zh) |
MX (1) | MXPA02006250A (zh) |
NO (1) | NO20022971L (zh) |
WO (1) | WO2001046156A1 (zh) |
ZA (1) | ZA200203796B (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001263850A1 (en) * | 2000-04-20 | 2001-11-07 | Actelion Pharmaceuticals Ltd | Pyrimidine-sulfonamides having endothelin-antagonist activity |
EP1345920B1 (en) * | 2000-12-18 | 2006-04-12 | Actelion Pharmaceuticals Ltd. | Novel sulfamides and their use as endothelin receptor antagonists |
MXPA06013941A (es) | 2004-06-08 | 2007-12-10 | Neurosearch Sweden Ab | Fenilpiperidinas disustituidas, novedosas, como moduladores de la neurotransmision de dopamina y serotonina. |
AR062501A1 (es) | 2006-08-29 | 2008-11-12 | Actelion Pharmaceuticals Ltd | Composiciones terapeuticas |
MX2010001837A (es) | 2007-08-17 | 2010-03-10 | Actelion Pharmaceuticals Ltd | Derivados de 4-pirimidinasulfamida. |
US8916385B2 (en) * | 2007-12-13 | 2014-12-23 | Quest Diagnostics Investments, Inc. | Methods for detecting estrone by mass spectrometry |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
CA2162630C (en) * | 1994-11-25 | 2007-05-01 | Volker Breu | Sulfonamides |
TW313568B (zh) * | 1994-12-20 | 1997-08-21 | Hoffmann La Roche | |
CZ289090B6 (cs) * | 1994-12-20 | 2001-10-17 | F. Hoffmann-La Roche Ag | Derivát arylsulfonamidu a heteroarylsulfonamidu, způsob jeho přípravy a jeho pouľití |
US5739333A (en) * | 1995-05-16 | 1998-04-14 | Tanabe Seiyaku Co., Ltd. | Sulfonamide derivative and process for preparing the same |
CZ260596A3 (en) * | 1995-10-12 | 1997-12-17 | Hoffmann La Roche | Sulfonamide derivative, process of its preparation and pharmaceutical composition containing thereof |
JP3087968B2 (ja) * | 1995-12-20 | 2000-09-18 | 山之内製薬株式会社 | アリールエテンスルホンアミド誘導体及びその医薬組成物 |
JP4125787B2 (ja) * | 1996-07-23 | 2008-07-30 | 塩野義製薬株式会社 | 新規ピリミジン化合物および医薬組成物 |
WO1999036408A1 (en) * | 1998-01-19 | 1999-07-22 | Shionogi & Co., Ltd. | Novel pyrimidine derivatives |
-
2000
- 2000-12-14 AU AU35367/01A patent/AU3536701A/en not_active Abandoned
- 2000-12-14 HU HU0204168A patent/HUP0204168A2/hu unknown
- 2000-12-14 KR KR1020027007566A patent/KR20020068373A/ko not_active Application Discontinuation
- 2000-12-14 CN CN00816718A patent/CN1407973A/zh active Pending
- 2000-12-14 CA CA002389479A patent/CA2389479A1/en not_active Abandoned
- 2000-12-14 IL IL14952900A patent/IL149529A0/xx unknown
- 2000-12-14 WO PCT/EP2000/012743 patent/WO2001046156A1/en not_active Application Discontinuation
- 2000-12-14 BR BR0016241-8A patent/BR0016241A/pt not_active Application Discontinuation
- 2000-12-14 JP JP2001547067A patent/JP2003518102A/ja active Pending
- 2000-12-14 MX MXPA02006250A patent/MXPA02006250A/es unknown
-
2002
- 2002-05-13 ZA ZA200203796A patent/ZA200203796B/en unknown
- 2002-06-20 NO NO20022971A patent/NO20022971L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20020068373A (ko) | 2002-08-27 |
NO20022971D0 (no) | 2002-06-20 |
JP2003518102A (ja) | 2003-06-03 |
HUP0204168A2 (hu) | 2003-04-28 |
AU3536701A (en) | 2001-07-03 |
IL149529A0 (en) | 2002-11-10 |
NO20022971L (no) | 2002-06-20 |
BR0016241A (pt) | 2002-11-12 |
ZA200203796B (en) | 2003-10-29 |
CN1407973A (zh) | 2003-04-02 |
WO2001046156A1 (en) | 2001-06-28 |
MXPA02006250A (es) | 2004-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1345920B1 (en) | Novel sulfamides and their use as endothelin receptor antagonists | |
US6596719B1 (en) | 6 alkoxy-4-pyrimidinyl bis-sulfonamides | |
CA2507334C (en) | Pyrimidine-sulfamides and their use as endothelian receptor antagonist | |
US7091201B2 (en) | Arylalkane-sulfonamides having endothelin-antagonist activity | |
AU2002212171A1 (en) | Arylalkane-sulfonamides having endothelin-antagonist activity | |
EP1309564B1 (en) | Arylethene-sulfonamides, their preparation and their use as endothelin antagonists | |
WO2001081338A1 (en) | Substituted sulfonylaminopyrimidines | |
WO2001081335A1 (en) | Pyrimidine-sulfonamides having endothelin-antagonist activity | |
CA2389479A1 (en) | Butyne diol derivatives | |
US6720322B2 (en) | Butyne diol derivatives | |
WO2002083650A1 (en) | Novel sulfonylamino-pyrimidines | |
EP1244637A1 (en) | Butyne diol derivatives | |
WO2003055863A1 (en) | Novel alkansulfonamides as endothelin antagonists | |
EP1465875B1 (en) | Novel alkansulfonamides as endothelin antagonists | |
EP1322624B1 (en) | Arylalkane-sulfonamides having endothelin-antagonist activity |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |