CA2383244A1 - Protein kinases - Google Patents

Protein kinases Download PDF

Info

Publication number
CA2383244A1
CA2383244A1 CA002383244A CA2383244A CA2383244A1 CA 2383244 A1 CA2383244 A1 CA 2383244A1 CA 002383244 A CA002383244 A CA 002383244A CA 2383244 A CA2383244 A CA 2383244A CA 2383244 A1 CA2383244 A1 CA 2383244A1
Authority
CA
Canada
Prior art keywords
seq
polypeptide
kinase
group
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002383244A
Other languages
English (en)
French (fr)
Inventor
Gregory D. Plowman
Ricardo Martinez
David Whyte
Sucha Sudersanam
Gerard Manning
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sugen LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2383244A1 publication Critical patent/CA2383244A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002383244A 1999-05-28 2000-05-26 Protein kinases Abandoned CA2383244A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13650399P 1999-05-28 1999-05-28
US60/136,503 1999-05-28
PCT/US2000/014842 WO2000073469A2 (en) 1999-05-28 2000-05-26 Protein kinases

Publications (1)

Publication Number Publication Date
CA2383244A1 true CA2383244A1 (en) 2000-12-07

Family

ID=22473127

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002383244A Abandoned CA2383244A1 (en) 1999-05-28 2000-05-26 Protein kinases

Country Status (6)

Country Link
US (1) US20060234344A1 (https=)
EP (1) EP1180151A2 (https=)
JP (1) JP2003501038A (https=)
AU (1) AU5173400A (https=)
CA (1) CA2383244A1 (https=)
WO (1) WO2000073469A2 (https=)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020028772A1 (en) * 1997-05-21 2002-03-07 Children's Med. Corporation, Modulators of activity of G-protein-coupled receptor kinases
US7037891B2 (en) 1997-05-21 2006-05-02 Children's Medical Center Corporation Methods of modulating G-protein-coupled receptor kinase-associated signal transduction
EP1032687A2 (en) 1998-08-04 2000-09-06 Immunex Corporation Human cdnas encoding polypeptides having kinase functions
AU5252799A (en) 1998-08-04 2000-02-28 Immunex Corporation Ikr-1 and ikr-2, protein kinases which are related to the i kappa b kinases
US20030028004A1 (en) * 2000-12-22 2003-02-06 Millennium Pharmaceuticals, Inc. 68730 and 69112, protein kinase molecules and uses therefor
US20020077312A1 (en) * 2000-09-25 2002-06-20 Millennium Pharmaceuticals, Inc. 3700, a novel human protein kinase and uses therefor
US6660490B2 (en) * 1998-12-11 2003-12-09 Millennnium Pharmaceuticals, Inc. CARK protein and nucleic acid molecules and uses therefor
US6261818B1 (en) * 1998-12-11 2001-07-17 Millennium Pharmaceuticals, Inc. CARK protein and nucleic acid molecules and uses therefor
CA2374612A1 (en) 1999-05-28 2000-12-07 Immunex Corporation Novel murine and human kinases
US7001752B1 (en) 1999-05-28 2006-02-21 Immunex Corporation Murine and human kinases
US6656698B1 (en) * 1999-06-30 2003-12-02 Millennium Pharmaceuticals, Inc. 12832, a novel human kinase-like molecule and uses thereof
CA2386213A1 (en) * 1999-09-28 2001-04-05 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
US6716616B1 (en) 1999-09-28 2004-04-06 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
EP1484408A1 (en) * 1999-09-28 2004-12-08 Lexicon Genetics Incorporated Human kinase proteins and polynucleotides encoding the same
CA2382859A1 (en) * 1999-10-07 2001-04-12 Genentech, Inc. Novel polypeptides, their nucleic acids, and methods for their use in angiogenesis and vascularization
US6428980B1 (en) * 1999-11-16 2002-08-06 Rigel Pharmaceuticals, Inc. Nucleic acids encoding RIP3 associated cell cycle proteins
AU1926001A (en) * 1999-11-24 2001-06-04 Sugen, Inc. Novel human protein kinases and protein kinase-like enzymes
EP1244695A2 (en) * 1999-12-10 2002-10-02 Incyte Genomics, Inc. Extracellular matrix and cell adhesion proteins as well as genes encoding them
GB9929542D0 (en) * 1999-12-14 2000-02-09 Glaxo Wellcome Kk Ikk4
US20020006618A1 (en) * 2000-02-09 2002-01-17 Galvin Katherine M. Methods for using 20893, a human protein kinase
AU2001238488A1 (en) * 2000-02-17 2001-08-27 Incyte Genomics, Inc. Human kinases
US7198930B2 (en) 2000-02-29 2007-04-03 Millennium Pharmaceuticals, Inc. Human protein kinase, phosphatase, and protease family members and uses thereof
US6864078B2 (en) 2000-02-29 2005-03-08 Millennium Pharmaceuticals, Inc. 14790, novel protein kinase molecule and uses therefor
WO2001066762A1 (en) * 2000-03-08 2001-09-13 Merck Patent Gmbh Human extracellular signal regulated kinases
US6458561B1 (en) 2000-03-13 2002-10-01 Incyte Genomics, Inc. Human NIM1 kinase
US20020025931A1 (en) 2000-03-24 2002-02-28 Rachel Meyers 3714, 16742, 23546, and 13887 novel protein kinase molecules and uses therefor
US20030198953A1 (en) * 2000-03-30 2003-10-23 Spytek Kimberly A. Novel proteins and nucleic acids encoding same
US20020090701A1 (en) * 2000-04-13 2002-07-11 Rosana Kapeller-Libermann 14257 novel protein kinase molecules and their uses therefor
JP2004511205A (ja) * 2000-04-25 2004-04-15 レキシコン・ジェネティクス・インコーポレーテッド 新規ヒトキナーゼプロテインおよびそれをコードするポリヌクレオチド
EP1294896A2 (en) * 2000-04-25 2003-03-26 Millennium Pharmaceuticals, Inc. 13295 novel protein kinase molecules and uses therefor
US20030108933A1 (en) * 2000-05-12 2003-06-12 Burkhard Scharm Novel serine-threonine kinase-3
WO2001085921A2 (en) * 2000-05-12 2001-11-15 Merck Patent Gmbh Human serine-threonine kinase-4
AU7634301A (en) * 2000-05-26 2001-12-03 Bayer Aktiengesellschaft Regulation of human p78-like serine/threonine kinase
US6413756B2 (en) 2000-06-06 2002-07-02 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6416990B2 (en) 2000-06-06 2002-07-09 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6323016B1 (en) 2000-06-09 2001-11-27 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
CA2410610A1 (en) * 2000-06-15 2001-12-20 Incyte Genomics, Inc. Human kinases
WO2002002780A2 (en) * 2000-07-05 2002-01-10 Merck Patent Gmbh Human serine-threonine kinase
EP1322768A2 (en) * 2000-07-28 2003-07-02 Chiron Corporation Isolation of drosophila and human polynucleotides encoding par-1 kinase, polypeptides encoded by the polynucleotides and methods utilizing the polynucleotides and polypeptides
WO2002012456A2 (en) * 2000-08-03 2002-02-14 1149336 Ontario Inc. Ampk-related serine/threonine kinase, designated snark
US6759221B1 (en) * 2000-08-18 2004-07-06 Millennium Pharmaceuticals, Inc. 14189, a novel human kinase and uses thereof
AU2001286575A1 (en) * 2000-08-21 2002-03-04 Millennium Pharmaceuticals, Inc. 15985, a human serine/threonine protein kinase family member and uses thereof
US6455291B1 (en) * 2000-08-24 2002-09-24 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6555352B2 (en) * 2000-08-31 2003-04-29 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US6372468B1 (en) 2000-09-14 2002-04-16 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
AU2002223950A1 (en) * 2000-09-20 2002-04-02 Qlt Inc. Cancer associated protein kinases and their uses
AU2002213183A1 (en) * 2000-10-12 2002-04-22 Lexicon Genetics Incorporated Human kinases and polynucleotides encoding the same
AU2002214021A1 (en) 2000-10-16 2002-04-29 Bayer Aktiengesellschaft Regulation of human serine-threonine protein kinase
WO2002033056A2 (en) * 2000-10-16 2002-04-25 Bayer Aktiengesellschaft Regulation of human serine-threonine protein kinase
IL155800A0 (en) * 2000-11-09 2003-12-23 Univ Virginia Nucleic acid sequences encoding human testis specific kinases
EP1443117B1 (en) * 2000-11-09 2010-08-11 University Of Virginia Patent Foundation Human testis specific serine/threonine kinase
AU2002239483A1 (en) * 2000-12-08 2002-06-18 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
CA2431210A1 (en) * 2000-12-12 2002-06-20 Lexicon Genetics Incorporated Novel human kinases and uses thereof
EP1676917A3 (en) * 2000-12-12 2006-07-12 Lexicon Genetics Incorporated Novel human kinases and uses thereof
US6410294B1 (en) * 2000-12-13 2002-06-25 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
CA2439800A1 (en) * 2000-12-14 2002-06-20 Pe Corporation (Ny) Isolated human kinase proteins, their encoding nucleic acid molecules, and uses thereof
US7119185B2 (en) * 2000-12-21 2006-10-10 Trustees Of The University Of Pennsylvania Hormonally up-regulated, neu-tumor-associated kinase
WO2002053749A2 (en) * 2001-01-03 2002-07-11 Bayer Aktiengesellschaft Regulation of human serine-threonine protein kinase
WO2002055681A2 (en) * 2001-01-11 2002-07-18 Bayer Ag Regulation of human tau-tubulin kinase
DE10102797A1 (de) * 2001-01-22 2003-05-08 Deutsches Krebsforsch HIPK-Kinasen und deren Verwendung zur Beeinflussung der Zellteilung und Zellproliferation
US6686176B2 (en) * 2001-01-23 2004-02-03 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
EP1227156A3 (en) * 2001-01-30 2004-01-02 Aeomica, Inc. A human protein kinase domain-containing protein
US6492154B2 (en) * 2001-01-31 2002-12-10 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
WO2002070678A2 (en) * 2001-02-05 2002-09-12 Bayer Aktiengesellschaft Regulation of human serine/threonine protein kinase
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same
US20030036183A1 (en) * 2001-05-10 2003-02-20 Boylan John F. Serine threonine kinase member, h2520-40
DE60237917D1 (de) 2001-06-05 2010-11-18 Exelixis Inc Gfats als modifikatoren des p53-wegs und verwendungsverfahren
AU2002312976A1 (en) * 2001-06-07 2002-12-16 Bayer Aktiengesellschaft Human serine/threonine protein kinase-like enzyme
US20030059918A1 (en) * 2001-06-07 2003-03-27 Bayer Aktiengesellschaft Regulation of human serine/threonine protein kinase
JP4491567B2 (ja) * 2001-07-19 2010-06-30 財団法人新産業創造研究機構 ヒト由来のスフィンゴシン・キナーゼ１に結合する新規タンパク質、及び当該タンパク質をコードするポリヌクレオチド
WO2003037257A2 (en) * 2001-10-31 2003-05-08 Millennium Pharmaceuticals, Inc. Methods and compositions for the diagnosis and treatment of cellular proliferation disorders using 20750
US20050053938A1 (en) * 2001-11-27 2005-03-10 Kohler Rainer H. Regulation of human serine/threonine protein kinase
US7482138B2 (en) 2001-12-28 2009-01-27 The Trustees Of Columbia University In The City Of New York PAK5-related compositions and methods
WO2003076577A2 (en) * 2002-03-05 2003-09-18 Applera Corporation Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
US7189551B2 (en) 2002-03-20 2007-03-13 Bioptik Technology, Inc. Human RPS6KA6-related gene variant associated with lung cancers
PT1536827E (pt) * 2002-08-14 2009-03-20 Silence Therapeutics Ag Utilização de proteína cinase n beta
EP1393742A1 (en) * 2002-08-14 2004-03-03 atugen AG Use of protein kinase N beta
WO2004018669A1 (ja) * 2002-08-21 2004-03-04 Proteinexpress Co., Ltd. 塩誘導性キナーゼ２及びその用途
CA2501752A1 (en) 2002-10-10 2004-04-22 Wyeth Compositions, organisms and methodologies employing a novel human kinase
MXPA05003673A (es) * 2002-10-10 2005-06-08 Wyeth Corp Composiciones, organismos y metodologias que emplean una cinasa humana novedosa.
EP1554385A2 (en) 2002-10-24 2005-07-20 Wyeth Calcineurin-like human phoshphoesterase
AU2003290664A1 (en) 2002-11-27 2004-06-23 Wei Liu Compositions, organisms and methodologies employing a novel human kinase
US7829682B1 (en) * 2003-04-30 2010-11-09 Incyte Corporation Human β-adrenergic receptor kinase nucleic acid molecule
GB0328928D0 (en) * 2003-12-12 2004-01-14 Cancer Rec Tech Ltd Materials and methods relating to cell cycle control
WO2006069782A2 (en) 2004-12-27 2006-07-06 Silence Therapeutics Ag. Lipid complexes coated with peg and their use
DE102004059781A1 (de) * 2004-12-10 2006-06-22 Sanofi-Aventis Deutschland Gmbh Verwendung der Serum-/Glucocorticoid regulierten Kinase
KR101670085B1 (ko) 2006-07-21 2016-10-28 사일런스 테라퓨틱스 게엠베하 단백질 키나아제 3의 발현을 억제하기 위한 수단
US8399637B2 (en) * 2006-08-24 2013-03-19 The Trustees Of The University Of Pennsylvania Nucleic acids encoding proteins for modulating Na,K-ATPase
WO2011042030A1 (en) * 2009-10-06 2011-04-14 Tallinn University Of Technology Inhibition or activation of serine/threonine ulk3 kinase activity
WO2025006571A1 (en) * 2023-06-26 2025-01-02 University Of Kentucky Research Foundation Targeted destruction of pask by peptide-based degron

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0658204B1 (en) * 1992-08-31 2002-06-05 Massachusetts Institute Of Technology DNA ENCODING THE HEME-REGULATED EUKARYOTIC INITIATION FACTOR 2$g(a) KINASE
NZ331866A (en) * 1996-03-15 2000-05-26 Corixa Corp Compounds for immunotherapy and immunodiagnosis of prostate cancer
DK0914451T3 (da) * 1996-06-10 2006-11-13 Immunex Corp IL-1/TNF-alpha-aktiveret kinase (ITAK) og fremgangsmåder til fremstilling og anvendelse deraf
US5863729A (en) * 1996-07-09 1999-01-26 Washington University DNA sequences encoding human TcAK1 kinase
US5863780A (en) * 1996-09-12 1999-01-26 Incyte Pharmaceuticals, Inc. Human Protein Kinases
EP0972026A2 (en) * 1997-01-21 2000-01-19 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
CA2280206A1 (en) * 1997-02-07 1998-08-13 Merck & Co., Inc. Cyclin-dependent protein kinase
US6479274B1 (en) * 1997-02-13 2002-11-12 Amrad Operations Pty., Ltd. DNA molecules encoding human HELA2 or testisin serine proteinases
DE19708173A1 (de) * 1997-02-28 1998-09-03 Dade Behring Marburg Gmbh Zellvolumenregulierte humane Kinase h-sgk
US5965420A (en) * 1997-03-05 1999-10-12 Smithkline Beecham Corporation Human protein kinases hYAK3
US5885803A (en) * 1997-06-19 1999-03-23 Incyte Pharmaceuticals, Inc. Disease associated protein kinases
EP0996857B1 (en) * 1997-07-17 2009-09-09 Ludwig Institute For Cancer Research Cancer associated nucleic acids and polypeptides
AU1991899A (en) * 1997-12-19 1999-07-12 Karolinska Innovations Ab Molecules associated with the human fused gene
AU1691499A (en) * 1997-12-26 1999-07-19 Asahi Kasei Kogyo Kabushiki Kaisha Novel kinase
US6432668B1 (en) * 1997-12-30 2002-08-13 Chiron Corporation Polynucleotides encoding human cyclin-dependent kinase (hPFTAIRE)
US5962232A (en) * 1998-01-30 1999-10-05 Incyte Pharmaceuticals, Inc. Protein kinase molecules
EP1073756A4 (en) * 1998-03-26 2003-01-22 Gene Logic Inc IDENTIFICATION OF A cDNA ASSOCIATED WITH HUMAN HEART ISCHEMISTRY
WO1999050395A1 (fr) * 1998-03-27 1999-10-07 Helix Research Institute Serine-threonine proteine-kinase exprimee dans le rein
WO1999057144A2 (en) * 1998-05-05 1999-11-11 Incyte Pharmaceuticals, Inc. Human transcriptional regulator molecules
JP2002514401A (ja) * 1998-05-13 2002-05-21 インサイト・ファーマスーティカルズ・インコーポレイテッド 細胞シグナルタンパク質
WO1999064589A1 (en) * 1998-06-11 1999-12-16 Astrazeneca Ab Human receptor tyrosine kinase
WO2000006728A2 (en) * 1998-07-28 2000-02-10 Incyte Pharmaceuticals, Inc. Phosphorylation effectors
US6262228B1 (en) * 1998-08-17 2001-07-17 Tularik Inc. IRAK3 polypeptides and methods
US6183962B1 (en) * 1998-09-09 2001-02-06 Millennium Pharmaceuticals, Inc. Protein kinase molecules and uses therefor
US6013455A (en) * 1998-10-15 2000-01-11 Incyte Pharmaceuticals, Inc. Protein kinase homologs
ATE373676T1 (de) * 1998-12-14 2007-10-15 Univ Dundee Verfahren zur aktivierung von sgk durch phosphorylierung.
CA2296792A1 (en) * 1999-02-26 2000-08-26 Genset S.A. Expressed sequence tags and encoded human proteins
JP2002538827A (ja) * 1999-03-18 2002-11-19 インサイト・ファーマスーティカルズ・インコーポレイテッド 細胞内リン酸化反応のレギュレータ
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'

Also Published As

Publication number Publication date
AU5173400A (en) 2000-12-18
WO2000073469A2 (en) 2000-12-07
US20060234344A1 (en) 2006-10-19
EP1180151A2 (en) 2002-02-20
JP2003501038A (ja) 2003-01-14
WO2000073469A3 (en) 2001-11-29

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