CA2383184A1 - Procede de preparation de h-tyr-d-ala-phe(f)-phe-nh2 - Google Patents

Procede de preparation de h-tyr-d-ala-phe(f)-phe-nh2 Download PDF

Info

Publication number
CA2383184A1
CA2383184A1 CA002383184A CA2383184A CA2383184A1 CA 2383184 A1 CA2383184 A1 CA 2383184A1 CA 002383184 A CA002383184 A CA 002383184A CA 2383184 A CA2383184 A CA 2383184A CA 2383184 A1 CA2383184 A1 CA 2383184A1
Authority
CA
Canada
Prior art keywords
group
derivative
ester
protecting group
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002383184A
Other languages
English (en)
Inventor
Marten Ellburg
Henry Franzen
Maths Nilsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CA2383184A1 publication Critical patent/CA2383184A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne un procédé nouveau et amélioré de préparation du tétrapeptide H-Tyr-D-Ala-Phe(F)-Phe-NH¿2? qui est un peptide de formule (I). On décrit ce tétrapeptide ou un sel pharmaceutiquement acceptable de ce dernier ainsi que de nouveaux intermédiaires utiles dans la préparation dudit tétrapeptide. Le nouveau procédé est une synthèse fragmentaire à étapes parallèles en nombre réduit qui est adaptée à la production de masse.
CA002383184A 1999-09-15 2000-09-07 Procede de preparation de h-tyr-d-ala-phe(f)-phe-nh2 Abandoned CA2383184A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9903291-4 1999-09-15
SE9903291A SE9903291D0 (sv) 1999-09-15 1999-09-15 New process
PCT/SE2000/001747 WO2001019849A1 (fr) 1999-09-15 2000-09-07 Procede de preparation de h-tyr-d-ala-phe(f)-phe-nh¿2?

Publications (1)

Publication Number Publication Date
CA2383184A1 true CA2383184A1 (fr) 2001-03-22

Family

ID=20416994

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002383184A Abandoned CA2383184A1 (fr) 1999-09-15 2000-09-07 Procede de preparation de h-tyr-d-ala-phe(f)-phe-nh2

Country Status (6)

Country Link
EP (1) EP1212350A1 (fr)
JP (1) JP2003509437A (fr)
AU (1) AU7466900A (fr)
CA (1) CA2383184A1 (fr)
SE (1) SE9903291D0 (fr)
WO (1) WO2001019849A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1594517T1 (sl) 2003-01-28 2007-10-31 Microbia Inc Sestavki za zdravljenje gastrointestinalnih motenj
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP4540568B2 (ja) * 2005-07-26 2010-09-08 株式会社トクヤマ Ｌ−カルノシンの製造方法
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
FR2928372B1 (fr) * 2008-03-10 2010-12-31 Solvay Procede de synthese peptidique
CA2726917C (fr) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
CA2730603C (fr) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase utiles dans le traitement des affections gastro-intestinales, de l'inflammation gastro-intestinale, du cancer gastro-intestinal et d'autres affections
CA2994066A1 (fr) 2008-12-03 2010-06-10 Synergy Pharmaceuticals, Inc. Formulations d'agonistes de guanylate cyclase c et methode d'utilisation
MX345283B (es) 2008-12-31 2017-01-24 Ardelyx Inc Compuestos y metodos para inhibir el antiporte mediado por intercambiador de iones de sodio/iones de hidrogeno (nhe) en el tratamiento de trastornos asociados con retencion de fluido o sobrecarga de sal y trastornos del tracto gastrointestinal.
WO2018129556A1 (fr) 2017-01-09 2018-07-12 Ardelyx, Inc. Composés et procédés pour l'inhibition d'un antiport à médiation par échangeur sodium/proton (nhe) dans le traitement de troubles associés à une rétention d'eau ou à une surcharge en sel et de troubles du tractus gastro-intestinal
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012118972A2 (fr) 2011-03-01 2012-09-07 Synegy Pharmaceuticals Inc. Procédé de préparation d'agonistes du guanylate cyclase c
MX366293B (es) 2012-08-21 2019-07-04 Ardelyx Inc Compuestos y metodos para inhibir al antipuerto mediado por nhe en el tratamiento de trastornos asociados con la retencion de fluidos o la sobrecarga de sal y trastornos del tracto gastrointestinal.
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
EP2970384A1 (fr) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
JP6377132B2 (ja) 2013-04-12 2018-08-22 アーデリクス，インコーポレーテッド Ｎｈｅ３結合化合物およびリン酸輸送の阻害方法
CN113388007A (zh) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
EP3565808A1 (fr) 2017-01-09 2019-11-13 Ardelyx, Inc. Composés utiles pour le traitement de troubles du tractus digestif
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2567524B1 (fr) * 1984-07-10 1987-11-27 Sanofi Sa Procede de synthese de la somatocrinine en phase liquide et peptides intermediaires
GB9516994D0 (en) * 1995-08-18 1995-10-18 Iaf Biochem Int Solution synthesis of peripheral acting analgestic opioid tetrapeptides
SE9800865D0 (sv) * 1998-03-16 1998-03-16 Astra Ab New Process

Also Published As

Publication number Publication date
AU7466900A (en) 2001-04-17
JP2003509437A (ja) 2003-03-11
WO2001019849A1 (fr) 2001-03-22
EP1212350A1 (fr) 2002-06-12
SE9903291D0 (sv) 1999-09-15

Similar Documents

Publication Publication Date Title
CA2383184A1 (fr) Procede de preparation de h-tyr-d-ala-phe(f)-phe-nh2
US9346850B2 (en) Method of producing peptide
AU8649098A (en) Phenethylamine derivatives
US5977302A (en) Liquid phase process for the preparation of GnRH peptides
US6211333B1 (en) Method for producing peptides and their salts which have an agonist activity of luteinizing hormone releasing hormones secreted from the hypothalamus
KR101268794B1 (ko) 슈도프롤린 다이펩타이드
Katakai Peptide synthesis using o-nitrophenylsulfenyl N-carboxy. alpha.-amino acid anhydrides
CA2315222A1 (fr) Unites structurales ramifiees pour synthetiser des peptides cycliques
WO2008000641A1 (fr) Pseudo dipeptides de proline
EP0410182A2 (fr) Technique pour le couplage rapide des peptides
AU2968899A (en) Process for the preparation of a tetrapeptide
US20040101864A1 (en) Chemical process
US3780015A (en) Process for preparing lysine containing peptides
EP0292228A2 (fr) Groupes protecteurs de l'asparagine et de la glutamine dans la synthèse peptidique
RU2111972C1 (ru) СПОСОБ ПОЛУЧЕНИЯ ПЕПТИДА δ СНА
EP0564587A1 (fr) Procede pour preparer en phase de solution un peptide
MXPA00008828A (en) Process for the preparation of a tetrapeptide
Sureshbabu et al. HOAt. DCHA as co-coupling agent in the synthesis of peptides employing Fmoc-amino acid chlorides as coupling agents: Application to the synthesis of β-casomorphin
HU189204B (en) Process for producing cholecistokinin-octapeptide-sulfate-ester and salts thereof
KR19990071181A (ko) 고체상 반응을 통한 아자펩티드 유도체의 제조방법
JPH035499A (ja) 新規トリペプチド並びにその製造方法及び使用
HU179926B (hu) Eljárás a gasztrin C-terminális tetrapeptid-szekvenciájának előállítására

Legal Events

Date Code Title Description
FZDE Dead