CA2382877A1 - Aminoalkylenephosphonates destines au traitement de maladies osseuses - Google Patents

Aminoalkylenephosphonates destines au traitement de maladies osseuses Download PDF

Info

Publication number
CA2382877A1
CA2382877A1 CA002382877A CA2382877A CA2382877A1 CA 2382877 A1 CA2382877 A1 CA 2382877A1 CA 002382877 A CA002382877 A CA 002382877A CA 2382877 A CA2382877 A CA 2382877A CA 2382877 A1 CA2382877 A1 CA 2382877A1
Authority
CA
Canada
Prior art keywords
aminoalkylenephosphonate
alk
pharmaceutically acceptable
acceptable salt
aminoalkylenephophonate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002382877A
Other languages
English (en)
Inventor
R. Keith Frank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Global Technologies LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2382877A1 publication Critical patent/CA2382877A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé destiné à empêcher ou à minimiser la perte de teneur minérale des os chez les mammifères. Ce procédé consiste à administrer à un mammifère une quantité efficace d'un aminoalkylènephosphonate destinée à empêcher ou à minimiser la perte de teneur minérale des os. Les aminoalkylènephosphonates de la présente invention contiennent au moins un groupe R-N(Alk-PO¿3?H¿2?)¿2? ou au moins deux groupes RRïN-Alk-PO¿3?H¿2? dans lesquels R et R' peuvent être égaux ou différents, une fraction aliphatique ou cyclique, et Alk représente un groupe alcoylène possédant 1 à 4 atomes de carbone.
CA002382877A 1999-10-18 2000-10-17 Aminoalkylenephosphonates destines au traitement de maladies osseuses Abandoned CA2382877A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16001999P 1999-10-18 1999-10-18
US60/160,019 1999-10-18
PCT/US2000/028713 WO2001028567A2 (fr) 1999-10-18 2000-10-17 Aminoalkylenephosphonates destines au traitement de maladies osseuses

Publications (1)

Publication Number Publication Date
CA2382877A1 true CA2382877A1 (fr) 2001-04-26

Family

ID=22575141

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002382877A Abandoned CA2382877A1 (fr) 1999-10-18 2000-10-17 Aminoalkylenephosphonates destines au traitement de maladies osseuses

Country Status (6)

Country Link
EP (1) EP1225903A2 (fr)
JP (1) JP2003512331A (fr)
CN (1) CN1378454A (fr)
AU (1) AU1092601A (fr)
CA (1) CA2382877A1 (fr)
WO (1) WO2001028567A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014522808A (ja) * 2011-06-17 2014-09-08 サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィク 二官能性ホスホネートキレート剤
RU2527439C2 (ru) * 2011-10-24 2014-08-27 Открытое акционерное общество "Полипласт" (ОАО "Полипласт") Биоцидная добавка для бетонов и строительных растворов

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4937333A (en) * 1989-08-04 1990-06-26 The Dow Chemical Company Method for purifying aminomethylenephosphonic acids for pharmaceutical use
IL106159A0 (en) * 1992-06-30 1993-10-20 Dow Chemical Co Targeted delivery of growth factors for bone regeneration
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US5714604A (en) * 1993-05-06 1998-02-03 The Dow Chemical Company Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives
US5902825A (en) * 1997-01-07 1999-05-11 Mitreoak, Ltd. Composition and method for the palliation of pain associated with diseases of the bone and bone joints

Also Published As

Publication number Publication date
WO2001028567A3 (fr) 2001-11-29
JP2003512331A (ja) 2003-04-02
AU1092601A (en) 2001-04-30
CN1378454A (zh) 2002-11-06
EP1225903A2 (fr) 2002-07-31
WO2001028567A2 (fr) 2001-04-26

Similar Documents

Publication Publication Date Title
YU54802A (sh) Farmaceutska parenteralna kompozicija koja sadrži bifosfonat
CA2120538C (fr) Utilisation de derives de l'acide disphosphonique pour promouvoir la reparation osseuse, et medicaments derives
AU693541B2 (en) Use of certain methanebisphosphonic acid derivatives to prevent prosthesis loosening and prosthesis migration
Fleisch Bisphosphonates: mechanisms of action and clinical use in osteoporosis-an update
WO1994014455A1 (fr) Therapie utilisant des bisphosphonates et des ×strogenes en vue de traiter et de prevenir la resorption osseuse
BG63102B1 (bg) Използване на бисфосфонати за инхибиране на костна резорбция след имплантиране на ортопедична протеза
US5616571A (en) Bisphosphonates prevent bone loss associated with immunosuppressive therapy
NZ515541A (en) Pharmaceutical compositions comprising bisphosphonates to treat angiogenesis
Brown et al. Developments in the therapeutic applications of bisphosphonates
Bell et al. Bisphosphonates in the treatment of osteoporosis
CA2396393A1 (fr) Utilisation de bisphosphonates a faible dose pour inhiber la calcification cardiaque et arterielle
Rossini et al. Intramuscular clodronate therapy in postmenopausal osteoporosis
JPS637526B2 (fr)
CA2409930A1 (fr) Utilisation de zoledronate pour la fabrication d'un medicament visant a traiter les troubles du metabolisme osseux
Shinkai et al. Alendronate
US6794371B1 (en) Aminoalkylenephosphonates for treatment of bone disorders
CA2382877A1 (fr) Aminoalkylenephosphonates destines au traitement de maladies osseuses
US6399592B1 (en) Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
CZ20012231A3 (cs) Použití bisfosfonátů k profylaxi a k ošetřování infekčních procesů
JP3796693B2 (ja) オルパドロネートからなる骨塊同化組成物
AU670337B2 (en) Use of certain methanebisphosphonic acid derivatives in fracture healing
CA2221416A1 (fr) Traitement par bisphosphonates de la deperdition osseuse associee a l'arthrite rhumatoide
AU2001277115A1 (en) Use of estramustine phosphate in the treatment of bone metastasis
Fleisch Bisphosphonates
DeRuiter et al. Bisphosphonates: calcium antiresorptive agents

Legal Events

Date Code Title Description
FZDE Dead