CA2382345A1 - Extended duration light activated cancer therapy - Google Patents
Extended duration light activated cancer therapy Download PDFInfo
- Publication number
- CA2382345A1 CA2382345A1 CA002382345A CA2382345A CA2382345A1 CA 2382345 A1 CA2382345 A1 CA 2382345A1 CA 002382345 A CA002382345 A CA 002382345A CA 2382345 A CA2382345 A CA 2382345A CA 2382345 A1 CA2382345 A1 CA 2382345A1
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- Prior art keywords
- light
- target tissue
- irradiating
- photosensitizer compound
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
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- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Radiation-Therapy Devices (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Surgical Instruments (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Families Citing this family (44)
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| US6602274B1 (en) * | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
| US6454789B1 (en) | 1999-01-15 | 2002-09-24 | Light Science Corporation | Patient portable device for photodynamic therapy |
| EP1131099A2 (en) * | 1999-01-15 | 2001-09-12 | Light Sciences Corporation | Noninvasive vascular therapy |
| US7897140B2 (en) | 1999-12-23 | 2011-03-01 | Health Research, Inc. | Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents |
| EP1267935A2 (en) * | 2000-01-12 | 2003-01-02 | Light Sciences Corporation | Novel treatment for eye disease |
| WO2002013820A1 (en) * | 2000-08-11 | 2002-02-21 | Ceramoptec Industries, Inc. | Photosensitizing ointment |
| US7223282B1 (en) | 2001-09-27 | 2007-05-29 | Advanced Cardiovascular Systems, Inc. | Remote activation of an implantable device |
| WO2003061696A2 (en) * | 2002-01-23 | 2003-07-31 | Light Sciences Corporation | Systems and methods for photodynamic therapy |
| IL148921A0 (en) | 2002-03-26 | 2002-09-12 | Peptor Ltd | Photo active backbone cyclized somatostatin analogs for optical imaging and photodynamic therapy |
| AU2003248747A1 (en) | 2002-06-27 | 2004-01-19 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
| EP1606291A2 (en) | 2002-07-02 | 2005-12-21 | Health Research, Inc. | Efficient synthesis of pyropheophorbide a and its dervatives |
| CN2885311Y (zh) | 2006-01-18 | 2007-04-04 | 郑成福 | 经尿道光动力疗法前列腺治疗仪 |
| US20080269846A1 (en) * | 2003-03-14 | 2008-10-30 | Light Sciences Oncology, Inc. | Device for treatment of blood vessels using light |
| US10376711B2 (en) * | 2003-03-14 | 2019-08-13 | Light Sciences Oncology Inc. | Light generating guide wire for intravascular use |
| US20060282132A1 (en) * | 2003-06-20 | 2006-12-14 | Keio University | Photodynamic therapy equipment, method for controlling photodynamic therapy equipment and method of photodynamic method |
| AU2005280528B2 (en) * | 2004-07-30 | 2010-12-23 | Adeza Biomedical Corporation | Oncofetal fibronectin as a marker for disease and other conditions and methods for detection of oncofetal fibronectin |
| US20060234959A1 (en) * | 2005-04-14 | 2006-10-19 | Advanced Photodynamic Technologies, Inc. | Photodynamic therapy utilizing multiple duty cycle light modulation |
| HRP20060149B1 (en) * | 2006-04-19 | 2008-11-30 | Institut "Ruđer Bošković" | Intelligent sequential illuminator photodynamic therapy |
| US8057464B2 (en) | 2006-05-03 | 2011-11-15 | Light Sciences Oncology, Inc. | Light transmission system for photoreactive therapy |
| AU2012203963B2 (en) * | 2006-06-07 | 2015-03-19 | Gary S. Rogers | Continuous low irradiance photodynamic therapy system and method |
| US8585707B2 (en) * | 2006-06-07 | 2013-11-19 | Gary S. Rogers | Continuous low irradiance photodynamic therapy method |
| US7993640B2 (en) | 2008-08-06 | 2011-08-09 | Light Sciences Oncology, Inc. | Enhancement of light activated therapy by immune augmentation using anti-CTLA-4 antibody |
| US20100256125A1 (en) * | 2009-04-06 | 2010-10-07 | Zila Pharmaceuticals, Inc. | Use of improved toluidine blue in photodynamic therapy |
| US20110008372A1 (en) * | 2009-07-08 | 2011-01-13 | Light Sciences Oncology, Inc. | Enhancement of light activated drug therapy through combination with other therapeutic agents |
| US20110009464A1 (en) * | 2009-07-09 | 2011-01-13 | Light Sciences Oncology, Inc. | Immune system stimulation by light therapy induced apoptotic cell death in abnormal tissue |
| EP3089690B1 (en) | 2014-01-04 | 2018-08-29 | CranioVation, Inc. | Device for use of photodynamic therapy |
| EP3110448B1 (en) * | 2014-02-26 | 2020-09-09 | The Board of Regents of The University of Texas System | Nitrobenzaldehyde proton release for manipulation of cellular acidosis |
| ES2589833B1 (es) * | 2015-05-15 | 2017-08-03 | Intermèdic Arfran, S.A. | Equipo para la terapia fotodinámica |
| US11890268B2 (en) * | 2018-04-11 | 2024-02-06 | Saint Louis University | Dibenzothiophene derivatives and methods of treating cancer therewith |
| JP7168770B2 (ja) * | 2018-09-20 | 2022-11-09 | エンビアル インコーポレイテッド | ヘリコバクター・ピロリ認知用高分子複合体及びそれを含む光線力学治療用組成物 |
| US12138308B2 (en) | 2018-09-20 | 2024-11-12 | Enbiar Inc. | Polymer composite for helicobacter pylori recognition and composition for photodynamic therapy comprising same |
| JP7474773B2 (ja) | 2019-02-13 | 2024-04-25 | アルフェウス メディカル，インク． | 非侵襲的音響化学療法 |
| JP2020138940A (ja) * | 2019-02-28 | 2020-09-03 | テルモ株式会社 | 治療方法 |
| US20220226471A1 (en) | 2019-05-29 | 2022-07-21 | Sonalasense,Inc. | Sonosensitization |
| JP7676366B2 (ja) * | 2020-03-30 | 2025-05-14 | テルモ株式会社 | 治療装置 |
| CA3185803A1 (en) | 2020-08-07 | 2022-02-10 | Vijay Agarwal | Ultrasound arrays for enhanced sonodynamic therapy for treating cancer |
| US11529153B2 (en) | 2020-08-21 | 2022-12-20 | University Of Washington | Vaccine generation |
| WO2022040258A1 (en) | 2020-08-21 | 2022-02-24 | University Of Washington | Disinfection method and apparatus |
| US11425905B2 (en) | 2020-09-02 | 2022-08-30 | University Of Washington | Antimicrobial preventive netting |
| US11458220B2 (en) | 2020-11-12 | 2022-10-04 | Singletto Inc. | Microbial disinfection for personal protection equipment |
| EP4323060A1 (en) * | 2021-04-16 | 2024-02-21 | Virtual Biotech - INH. Yon Chong Kim | Systems, methods, and substances for controlled endoluminal energy application |
| US20240350828A1 (en) * | 2021-08-31 | 2024-10-24 | Board Of Regents, The University Of Texas System | Theranostic Methods |
| US12359369B2 (en) | 2022-08-11 | 2025-07-15 | Singletto Inc. | Skin protection against microbial particles |
| EP4556063A4 (en) * | 2023-03-03 | 2025-06-25 | Illumi Medical Inc. | LIGHT IRRADIATION DEVICE AND LIGHT IRRADIATION SYSTEM |
Family Cites Families (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4521762A (en) * | 1981-08-27 | 1985-06-04 | Gte Automatic Electric Laboratories, Incorporated | Integratable D/A converter |
| US4649151A (en) * | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
| US4577636A (en) * | 1982-11-23 | 1986-03-25 | The Beth Israel Hospital Association | Method for diagnosis of atherosclerosis |
| US4693885A (en) * | 1984-07-18 | 1987-09-15 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| US4675338A (en) * | 1984-07-18 | 1987-06-23 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| US4753958A (en) * | 1985-02-07 | 1988-06-28 | University Of Cal | Photochemotherapy of epithelial diseases with derivatives of hematoporphyrins |
| US4656186A (en) * | 1985-04-30 | 1987-04-07 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| US5066274A (en) * | 1985-04-30 | 1991-11-19 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole therapeutic agents |
| US5534506A (en) * | 1986-01-02 | 1996-07-09 | University Of Toledo | Use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US5216012A (en) * | 1986-01-02 | 1993-06-01 | University Of Toledo | Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US5051415A (en) * | 1986-01-02 | 1991-09-24 | The University Of Toledo | Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US4861876A (en) * | 1986-11-26 | 1989-08-29 | Wayne State University | Hematoporphyrin derivative and method of preparation and purification |
| US5095030A (en) * | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US4878891A (en) * | 1987-06-25 | 1989-11-07 | Baylor Research Foundation | Method for eradicating infectious biological contaminants in body tissues |
| US4957481A (en) * | 1987-10-01 | 1990-09-18 | U.S. Bioscience | Photodynamic therapeutic technique |
| US5004811A (en) * | 1987-12-24 | 1991-04-02 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole aminocarboxylic acids |
| US5053006A (en) * | 1988-04-19 | 1991-10-01 | Watson Brant D | Method for the permanent occlusion of arteries |
| US4925736A (en) * | 1988-07-06 | 1990-05-15 | Long Island Jewish Medical Center | Topical hematoporphyrin |
| US5028594A (en) * | 1988-12-27 | 1991-07-02 | Naxcor | Use of photodynamic compositions for cytotoxic effects |
| US4935498A (en) * | 1989-03-06 | 1990-06-19 | Board Of Regents, The University Of Texas System | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
| US5041078A (en) * | 1989-03-06 | 1991-08-20 | Baylor Research Foundation, A Nonprofit Corporation Of The State Of Texas | Photodynamic viral deactivation with sapphyrins |
| US4997639A (en) * | 1989-11-27 | 1991-03-05 | Nippon Petrochemicals Company, Limited | Method for detecting cholesterol deposited in bodies of mammals |
| US5594136A (en) * | 1989-12-21 | 1997-01-14 | Pharmacyclics, Inc. | Texaphyrin solid supports and devices |
| US5238940A (en) * | 1990-03-22 | 1993-08-24 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
| US5484778C1 (en) * | 1990-07-17 | 2001-05-08 | Univ Cleveland Hospitals | Phthalocynine photosensitizers for photodynamic therapy and methods for their use |
| US5549660A (en) * | 1990-11-15 | 1996-08-27 | Amron, Ltd. | Method of treating acne |
| US5500009A (en) * | 1990-11-15 | 1996-03-19 | Amron, Ltd. | Method of treating herpes |
| JP3154742B2 (ja) * | 1991-04-30 | 2001-04-09 | 日本石油化学株式会社 | 哺乳類の動脈硬化症治療剤 |
| US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
| US5807881A (en) * | 1992-05-27 | 1998-09-15 | Quadra Logic Technologies, Inc. | Method for selectively reducing activated leukocyte cell population |
| US5976535A (en) * | 1992-06-09 | 1999-11-02 | Neorx Corporation | Pretargeting protocols for the enhanced localization of cytotoxins to target sites and cytotoxic combinations useful therefore |
| US5298018A (en) * | 1992-08-14 | 1994-03-29 | Pdt Cardiovascular, Inc. | Method for treating cardiovascular disease through adjunctive photodynamic therapy |
| EP0660712B1 (en) * | 1992-09-21 | 2001-05-30 | Quadra Logic Technologies Inc. | Transcutaneous in vivo activation of photosensitive agents in blood |
| FI952436L (fi) * | 1992-11-20 | 1995-07-05 | Univ British Columbia | Menetelmä valoherkkien aineiden aktivoimiseksi |
| US5368841A (en) * | 1993-02-11 | 1994-11-29 | The General Hospital Corporation | Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides |
| JP3565442B2 (ja) * | 1993-04-22 | 2004-09-15 | 新日本石油化学株式会社 | 哺乳類の関節炎の診断剤および／または治療剤 |
| US5445608A (en) * | 1993-08-16 | 1995-08-29 | James C. Chen | Method and apparatus for providing light-activated therapy |
| US5514669A (en) * | 1993-09-29 | 1996-05-07 | Medical College Of Ohio | Use of photodynamic therapy to treat prostatic tissue |
| US5441531A (en) * | 1993-10-18 | 1995-08-15 | Dusa Pharmaceuticals Inc. | Illuminator and methods for photodynamic therapy |
| US5556612A (en) * | 1994-03-15 | 1996-09-17 | The General Hospital Corporation | Methods for phototherapeutic treatment of proliferative skin diseases |
| US5498710A (en) * | 1994-04-22 | 1996-03-12 | Health Research, Inc. | Alkyl ether analogues of benzoporphyrin derivatives |
| ITFI940095A1 (it) * | 1994-05-23 | 1995-11-23 | Molteni & C | Coniugati fotodinamici aventi proprieta' biocide |
| US5591847A (en) * | 1994-05-23 | 1997-01-07 | Health Research, Inc. | Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages |
| DE4445065A1 (de) * | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| US5882328A (en) * | 1995-01-13 | 1999-03-16 | Qlt Phototherapeutics, Inc. | Method to prevent transplant rejection |
| US6107325A (en) * | 1995-01-17 | 2000-08-22 | Qlt Phototherapeutics, Inc. | Green porphyrins as immunomodulators |
| US5643334A (en) * | 1995-02-07 | 1997-07-01 | Esc Medical Systems Ltd. | Method and apparatus for the diagnostic and composite pulsed heating and photodynamic therapy treatment |
| US5576013A (en) * | 1995-03-21 | 1996-11-19 | Eastern Virginia Medical School | Treating vascular and neoplastic tissues |
| US5571152A (en) * | 1995-05-26 | 1996-11-05 | Light Sciences Limited Partnership | Microminiature illuminator for administering photodynamic therapy |
| IT1275571B (it) * | 1995-07-19 | 1997-08-07 | Consiglio Nazionale Ricerche | Substrati fluorogenici suscettibili di fotoattivazione previa trasformazione per via enzimatica atti alla diagnosi ed alla terapia fotodinamica dei tumori |
| AU7237896A (en) * | 1995-09-06 | 1997-03-27 | Research Foundation Of The State University Of New York, The | Two-photon upconverting dyes and applications |
| JP2961074B2 (ja) * | 1995-09-06 | 1999-10-12 | 明治製菓株式会社 | 光化学療法用の新生血管閉塞剤 |
| US5824080A (en) * | 1995-09-28 | 1998-10-20 | The General Hospital Corporation | Photochemistry for the preparation of biologic grafts--allografts and xenografts |
| WO1997026885A1 (en) * | 1996-01-23 | 1997-07-31 | The General Hospital Corporation Doing Business As Massachusetts General Hospital | Benzophenothiazine and benzoporphyrin dye combination photodynamic therapy of tumors |
| US5885557A (en) * | 1996-02-08 | 1999-03-23 | Estee Lauder Inc. | Compositions useful in the phototherapeutic treatment of proliferative skin disorders |
| US5800478A (en) * | 1996-03-07 | 1998-09-01 | Light Sciences Limited Partnership | Flexible microcircuits for internal light therapy |
| US5952366A (en) * | 1996-03-08 | 1999-09-14 | Health Research, Inc. | Alkyl ether analogs of chlorins having an N-substituted imide ring |
| DE19702898A1 (de) * | 1996-04-04 | 1998-07-23 | Somatex Medizintechnische Inst | Laser-Applikationskatheter |
| AU3813897A (en) * | 1996-07-25 | 1998-02-20 | Light Medicine, Inc. | Photodynamic therapy apparatus and methods |
| US5814008A (en) * | 1996-07-29 | 1998-09-29 | Light Sciences Limited Partnership | Method and device for applying hyperthermia to enhance drug perfusion and efficacy of subsequent light therapy |
| US5715837A (en) * | 1996-08-29 | 1998-02-10 | Light Sciences Limited Partnership | Transcutaneous electromagnetic energy transfer |
| US5849027A (en) * | 1996-09-04 | 1998-12-15 | Mbg Technologies, Inc. | Photodynamic therapy method and apparatus |
| US5913884A (en) * | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
| KR100463478B1 (ko) * | 1996-10-01 | 2004-12-29 | 와이스 가부시키가이샤 | 이미노클로린아스파르트산 유도체 |
| US5942534A (en) * | 1996-10-10 | 1999-08-24 | The General Hospital Corporation | Photodynamic therapy for the treatment of osteoarthritis |
| US5832931A (en) * | 1996-10-30 | 1998-11-10 | Photogen, Inc. | Method for improved selectivity in photo-activation and detection of molecular diagnostic agents |
| US5741316A (en) * | 1996-12-02 | 1998-04-21 | Light Sciences Limited Partnership | Electromagnetic coil configurations for power transmission through tissue |
| US6080160A (en) * | 1996-12-04 | 2000-06-27 | Light Sciences Limited Partnership | Use of shape memory alloy for internally fixing light emitting device at treatment site |
| US5782896A (en) * | 1997-01-29 | 1998-07-21 | Light Sciences Limited Partnership | Use of a shape memory alloy to modify the disposition of a device within an implantable medical probe |
| US5876427A (en) * | 1997-01-29 | 1999-03-02 | Light Sciences Limited Partnership | Compact flexible circuit configuration |
| US5827186A (en) * | 1997-04-11 | 1998-10-27 | Light Sciences Limited Partnership | Method and PDT probe for minimizing CT and MRI image artifacts |
| US5957960A (en) * | 1997-05-05 | 1999-09-28 | Light Sciences Limited Partnership | Internal two photon excitation device for delivery of PDT to diffuse abnormal cells |
| US6100893A (en) * | 1997-05-23 | 2000-08-08 | Light Sciences Limited Partnership | Constructing solid models using implicit functions defining connectivity relationships among layers of an object to be modeled |
| US5921244A (en) * | 1997-06-11 | 1999-07-13 | Light Sciences Limited Partnership | Internal magnetic device to enhance drug therapy |
| CA2298526A1 (en) * | 1997-07-28 | 1999-02-04 | Dermatolazer Technologies Ltd | Phototherapy based method for treating pathogens and composition for effecting same |
| US6138681A (en) * | 1997-10-13 | 2000-10-31 | Light Sciences Limited Partnership | Alignment of external medical device relative to implanted medical device |
| US5865840A (en) * | 1997-10-22 | 1999-02-02 | Light Sciences Limited Partnership | Enhancement of light activation effect by immune augmentation |
| US6071944A (en) * | 1997-11-12 | 2000-06-06 | Bowling Green State University | Method of treatment of pigmented cancer cells utilizing photodynamic therapy |
| US6123923A (en) * | 1997-12-18 | 2000-09-26 | Imarx Pharmaceutical Corp. | Optoacoustic contrast agents and methods for their use |
| US6281611B1 (en) * | 1998-02-10 | 2001-08-28 | Light Sciences Corporation | Use of moving element to produce heat |
| US5945762A (en) * | 1998-02-10 | 1999-08-31 | Light Sciences Limited Partnership | Movable magnet transmitter for inducing electrical current in an implanted coil |
| US6103751A (en) * | 1998-06-22 | 2000-08-15 | Health Research, Inc. | Carotene analogs of porphyrins, chlorins and bacteriochlorins as therapeutic and diagnostic agents |
| US6416531B2 (en) * | 1998-06-24 | 2002-07-09 | Light Sciences Corporation | Application of light at plural treatment sites within a tumor to increase the efficacy of light therapy |
| US6096066A (en) * | 1998-09-11 | 2000-08-01 | Light Sciences Limited Partnership | Conformal patch for administering light therapy to subcutaneous tumors |
| US6117862A (en) * | 1998-10-09 | 2000-09-12 | Qlt, Inc. | Model and method for angiogenesis inhibition |
| US6344050B1 (en) * | 1998-12-21 | 2002-02-05 | Light Sciences Corporation | Use of pegylated photosensitizer conjugated with an antibody for treating abnormal tissue |
| US6602274B1 (en) * | 1999-01-15 | 2003-08-05 | Light Sciences Corporation | Targeted transcutaneous cancer therapy |
| US6273904B1 (en) * | 1999-03-02 | 2001-08-14 | Light Sciences Corporation | Polymer battery for internal light device |
| US6210425B1 (en) * | 1999-07-08 | 2001-04-03 | Light Sciences Corporation | Combined imaging and PDT delivery system |
| US6238426B1 (en) * | 1999-07-19 | 2001-05-29 | Light Sciences Corporation | Real-time monitoring of photodynamic therapy over an extended time |
| US6534040B2 (en) * | 1999-12-23 | 2003-03-18 | Health Research, Inc. | Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals |
| EP1267935A2 (en) * | 2000-01-12 | 2003-01-02 | Light Sciences Corporation | Novel treatment for eye disease |
| US20020030342A1 (en) * | 2000-04-05 | 2002-03-14 | Christopher Rotz | Handcycle |
| US6520669B1 (en) * | 2000-06-19 | 2003-02-18 | Light Sciences Corporation | Flexible substrate mounted solid-state light sources for exterior vehicular lighting |
| US6495585B2 (en) * | 2001-03-07 | 2002-12-17 | Health Research, Inc. | Method for treating hyperproliferative tissue in a mammal |
| WO2003061696A2 (en) * | 2002-01-23 | 2003-07-31 | Light Sciences Corporation | Systems and methods for photodynamic therapy |
| AU2003248747A1 (en) * | 2002-06-27 | 2004-01-19 | Health Research, Inc. | Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy |
| EP1606291A2 (en) * | 2002-07-02 | 2005-12-21 | Health Research, Inc. | Efficient synthesis of pyropheophorbide a and its dervatives |
-
1999
- 1999-08-31 US US09/386,692 patent/US20030114434A1/en not_active Abandoned
-
2000
- 2000-08-31 EP EP00957944A patent/EP1212057A4/en not_active Withdrawn
- 2000-08-31 JP JP2001519908A patent/JP2003508124A/ja active Pending
- 2000-08-31 CA CA002382345A patent/CA2382345A1/en not_active Abandoned
- 2000-08-31 WO PCT/US2000/024120 patent/WO2001015694A1/en not_active Ceased
- 2000-08-31 AU AU69494/00A patent/AU6949400A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003508124A (ja) | 2003-03-04 |
| WO2001015694A9 (en) | 2002-09-12 |
| EP1212057A4 (en) | 2006-01-04 |
| AU6949400A (en) | 2001-03-26 |
| US20030114434A1 (en) | 2003-06-19 |
| WO2001015694A1 (en) | 2001-03-08 |
| EP1212057A1 (en) | 2002-06-12 |
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