CA2377513A1 - Peptides bispirales a hetero-association - Google Patents

Peptides bispirales a hetero-association Download PDF

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Publication number
CA2377513A1
CA2377513A1 CA002377513A CA2377513A CA2377513A1 CA 2377513 A1 CA2377513 A1 CA 2377513A1 CA 002377513 A CA002377513 A CA 002377513A CA 2377513 A CA2377513 A CA 2377513A CA 2377513 A1 CA2377513 A1 CA 2377513A1
Authority
CA
Canada
Prior art keywords
poly
peptide
hetero
associating
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002377513A
Other languages
English (en)
Inventor
Andreas Pluckthun
Katja Arndt
Kristian Muller
Joelle Pelletier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Zuerich
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2377513A1 publication Critical patent/CA2377513A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés relatifs à l'identification de peptides bispiralés à hétéro-association et les utilisations de ces peptides pour l'hétérodimérisation de protéines de fusion. L'invention concerne en outre des vecteurs et des cellules hôtes utiles pour l'élaboration des peptides considérés, ainsi que des (poly)peptides/protéines renfermant lesdits peptides.
CA002377513A 1999-06-25 2000-06-26 Peptides bispirales a hetero-association Abandoned CA2377513A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34409699A 1999-06-25 1999-06-25
US09/344,096 1999-06-25
PCT/EP2000/005922 WO2001000814A2 (fr) 1999-06-25 2000-06-26 Peptides bispirales a hetero-association

Publications (1)

Publication Number Publication Date
CA2377513A1 true CA2377513A1 (fr) 2001-01-04

Family

ID=23349034

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002377513A Abandoned CA2377513A1 (fr) 1999-06-25 2000-06-26 Peptides bispirales a hetero-association

Country Status (3)

Country Link
EP (1) EP1194539A2 (fr)
CA (1) CA2377513A1 (fr)
WO (1) WO2001000814A2 (fr)

Families Citing this family (37)

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Publication number Priority date Publication date Assignee Title
US7192596B2 (en) 1996-08-23 2007-03-20 The Health Protection Agency Ipsen Limited Recombinant toxin fragments
US20030035798A1 (en) 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
CA2377573A1 (fr) * 1999-06-26 2001-01-04 Joelle Nina Pelletier Selection in vivo bibliotheque contre bibliotheque d'interactions proteine-proteine optimisees
US7030219B2 (en) 2000-04-28 2006-04-18 Johns Hopkins University B7-DC, Dendritic cell co-stimulatory molecules
ES2370417T3 (es) 2005-06-03 2011-12-15 Ares Trading S.A. Producción de una proteína de unión a il-18 recombinante.
EP1999154B1 (fr) * 2006-03-24 2012-10-24 Merck Patent GmbH Domaines de proteine heterodimerique d'ingenierie
US7989173B2 (en) 2006-12-27 2011-08-02 The Johns Hopkins University Detection and diagnosis of inflammatory disorders
CA2735006A1 (fr) 2008-08-25 2010-03-11 Amplimmune, Inc. Antagonistes de pd-1 et leurs procedes d'utilisation
FR2948940B1 (fr) 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
IN2012DN02753A (fr) 2009-08-31 2015-09-18 Amplimmune Inc
CA3079122A1 (fr) 2010-03-26 2011-09-29 Trustees Of Dartmouth College Vista, une proteine mediatrice regulatrice des lymphocytes t, agents de liaison a vista et utilisation associee
US10745467B2 (en) 2010-03-26 2020-08-18 The Trustees Of Dartmouth College VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
US20150231215A1 (en) 2012-06-22 2015-08-20 Randolph J. Noelle VISTA Antagonist and Methods of Use
CN107441480A (zh) 2010-06-30 2017-12-08 卡姆普根有限公司 多肽及其作为用于治疗多发性硬化、类风湿性关节炎以及其他自身免疫病症的药物的用途
WO2012035518A1 (fr) 2010-09-17 2012-03-22 Compugen Ltd. Compositions et procédés de traitement d'un myélome multiple résistant aux médicaments
US9409987B2 (en) 2011-04-15 2016-08-09 Compugen Ltd Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
EP2726503B1 (fr) 2011-06-30 2019-09-04 Compugen Ltd. Polypeptides et leurs utilisations pour traiter les troubles auto-immuns et l'infection
US9890215B2 (en) 2012-06-22 2018-02-13 King's College London Vista modulators for diagnosis and treatment of cancer
JP6309518B2 (ja) * 2012-07-05 2018-04-11 ジェネンテック， インコーポレイテッド 発現及び分泌システム
CN105246507B (zh) 2012-09-07 2019-01-25 达特茅斯大学理事会 用于诊断和治疗癌症的vista调节剂
RS60026B1 (sr) 2013-02-18 2020-04-30 Vegenics Pty Ltd Molekuli koji vezuju ligande i njihove upotrebe
US20160146806A1 (en) 2013-05-17 2016-05-26 Amplimmune, Inc. Receptors for b7-h4
ES2920677T3 (es) 2013-12-24 2022-08-08 Janssen Pharmaceutica Nv Anticuerpos y fragmentos anti-VISTA
US11014987B2 (en) 2013-12-24 2021-05-25 Janssen Pharmaceutics Nv Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
MX2016016310A (es) 2014-06-11 2017-10-20 A Green Kathy Uso de agonistas y antagonistas vista para suprimir o aumentar la inmunidad humoral.
JP2016002009A (ja) * 2014-06-13 2016-01-12 国立大学法人名古屋大学 タグ付抗体
US20170275344A1 (en) 2014-08-26 2017-09-28 Compugen Ltd. Polypeptides and uses thereof as a drug for treatment of autoimmune disorders
WO2016090347A1 (fr) 2014-12-05 2016-06-09 Immunext, Inc. Identification de vsig8 en tant que récepteur putatif de vista et son utilisation pour produire des modulateurs de vista/vsig8
DK3313882T3 (da) 2015-06-24 2020-05-11 Janssen Pharmaceutica Nv Anti-VISTA antistoffer og fragmenter
WO2017009712A1 (fr) 2015-07-13 2017-01-19 Compugen Ltd. Compositions de hide1 et méthodes associées
CA3014013A1 (fr) 2016-02-12 2017-08-17 Janssen Pharmaceutica Nv Anticorps anti-vista (b7h5)
MA44776A (fr) 2016-04-15 2019-03-06 Immunext Inc Anticorps anti-vista humain et leur utilisation
WO2018027042A1 (fr) 2016-08-03 2018-02-08 Bio-Techne Corporation Identification de vsig3/vista comme nouveau point de contrôle immunitaire et son utilisation en immunothérapie
CN110036034A (zh) 2016-12-09 2019-07-19 西雅图遗传学公司 卷曲螺旋掩蔽的二价抗体
WO2019152810A1 (fr) 2018-02-02 2019-08-08 Bio-Techne Corporation Composés permettant de moduler l'interaction de vista et de vsig3, procédés de fabrication et d'utilisation
EP3790904A1 (fr) * 2018-05-08 2021-03-17 Amgen Inc. Anticorps bispécifiques ayant des étiquettes appairées à des charges c-terminales clivables
WO2022227066A1 (fr) * 2021-04-30 2022-11-03 深圳普瑞金生物药业有限公司 PROCÉDÉ POUR LE CRIBLAGE DE MUTANTS D'HETERODIMÈRES αβ-TCR

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2196496A1 (fr) * 1997-01-31 1998-07-31 Stephen William Watson Michnick Epreuve de complementation de fragments de proteines pour la detection d'interactions entre proteines

Also Published As

Publication number Publication date
WO2001000814A3 (fr) 2001-03-22
EP1194539A2 (fr) 2002-04-10
WO2001000814A2 (fr) 2001-01-04

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20050627