CA2377427A1 - Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori - Google Patents

Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori Download PDF

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Publication number
CA2377427A1
CA2377427A1 CA002377427A CA2377427A CA2377427A1 CA 2377427 A1 CA2377427 A1 CA 2377427A1 CA 002377427 A CA002377427 A CA 002377427A CA 2377427 A CA2377427 A CA 2377427A CA 2377427 A1 CA2377427 A1 CA 2377427A1
Authority
CA
Canada
Prior art keywords
seq
leu
glycosyltransferase
lys
lps
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002377427A
Other languages
English (en)
Inventor
Susan M. Logan
Warren Wakarchuk
Wayne Conlan
Mario A. Monteiro
Eleonora Altman
Koji Hiratsuka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2377427A1 publication Critical patent/CA2377427A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne de nouveaux polynucléotides isolés codant pour les glycosyltransférases participant à la biosynthèse du lipopolysaccharide de Helicobacter pylori ainsi que des structures d'ADN et des vecteurs recombinants contenant des séquences polynucléotidiques codant pour ces glycosyltransférases. Ces structures d'acides nucléiques et vecteurs peuvent être utilisés dans la préparation des glycosyltransférases pour lesquelles elles codent au moyen de l'expression des séquences polynucléotidiques codantes dans des cellules cibles appropriés. L'invention concerne aussi des polypeptides isolés possédant l'activité enzymatique des glycosyltransférases de Helicobacter. Ces polypeptides sont particulièrement utiles pour cribler les modulateurs de leur activité enzymatique, notamment les inhibiteurs enzymatiques possédant une éventuelle activité antibactérienne.
CA002377427A 1999-06-28 2000-06-28 Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori Abandoned CA2377427A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14082099P 1999-06-28 1999-06-28
US60/140,820 1999-06-28
PCT/CA2000/000777 WO2001000796A2 (fr) 1999-06-28 2000-06-28 Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori

Publications (1)

Publication Number Publication Date
CA2377427A1 true CA2377427A1 (fr) 2001-01-04

Family

ID=22492927

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002377427A Abandoned CA2377427A1 (fr) 1999-06-28 2000-06-28 Glycosyltransferases de helicobacter pylori utilisees comme nouvelle cible dans la prevention et le traitement des infections par h. pylori

Country Status (3)

Country Link
AU (1) AU5668400A (fr)
CA (1) CA2377427A1 (fr)
WO (1) WO2001000796A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110997714A (zh) * 2017-02-17 2020-04-10 赛诺菲 对肌营养不良蛋白聚糖和层粘连蛋白-2具有特异性的多特异性结合分子

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11221079A (ja) 1998-02-04 1999-08-17 Kyowa Hakko Kogyo Co Ltd 糖転移酵素および該酵素をコードするｄｎａ
EP1299549A1 (fr) * 2000-06-28 2003-04-09 National Research Council of Canada Polypeptides de l'heptosyltransferase d'helicobacter pylori
EP1299527A2 (fr) * 2000-06-28 2003-04-09 National Research Council Of Canada Helicobacter dd-heptosyltransferase
GB0017149D0 (en) * 2000-07-12 2000-08-30 Chiron Spa Helicobacter pylori mutants

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK165197A3 (en) * 1995-06-07 1999-01-11 Astra Ab Nucleic acid and amino acid sequences relating to helicobacter pylori for diagnostics and therapeutics
JPH11221079A (ja) * 1998-02-04 1999-08-17 Kyowa Hakko Kogyo Co Ltd 糖転移酵素および該酵素をコードするｄｎａ

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110997714A (zh) * 2017-02-17 2020-04-10 赛诺菲 对肌营养不良蛋白聚糖和层粘连蛋白-2具有特异性的多特异性结合分子
CN110997714B (zh) * 2017-02-17 2024-05-03 赛诺菲 对肌营养不良蛋白聚糖和层粘连蛋白-2具有特异性的多特异性结合分子

Also Published As

Publication number Publication date
WO2001000796A2 (fr) 2001-01-04
AU5668400A (en) 2001-01-31
WO2001000796A3 (fr) 2001-08-09

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued