CA2377254C - Non-malignant disease treatment with ras antagonists - Google Patents
Non-malignant disease treatment with ras antagonists Download PDFInfo
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- CA2377254C CA2377254C CA002377254A CA2377254A CA2377254C CA 2377254 C CA2377254 C CA 2377254C CA 002377254 A CA002377254 A CA 002377254A CA 2377254 A CA2377254 A CA 2377254A CA 2377254 C CA2377254 C CA 2377254C
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- 230000025033 vasoconstriction Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/60—Salicylic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14019299P | 1999-06-18 | 1999-06-18 | |
| US60/140,192 | 1999-06-18 | ||
| PCT/US2000/016863 WO2000078303A1 (en) | 1999-06-18 | 2000-06-19 | Non-malignant disease treatment with ras antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2377254A1 CA2377254A1 (en) | 2000-12-28 |
| CA2377254C true CA2377254C (en) | 2009-08-18 |
Family
ID=22490144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002377254A Expired - Fee Related CA2377254C (en) | 1999-06-18 | 2000-06-19 | Non-malignant disease treatment with ras antagonists |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6462086B1 (enExample) |
| EP (1) | EP1187605A4 (enExample) |
| JP (1) | JP2003502365A (enExample) |
| AU (1) | AU5497000A (enExample) |
| CA (1) | CA2377254C (enExample) |
| WO (1) | WO2000078303A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2477604A1 (en) | 2002-03-13 | 2003-09-25 | Signum Biosciences, Inc. | Modulation of protein methylation and phosphoprotein phosphate |
| WO2004103352A1 (en) * | 2003-05-23 | 2004-12-02 | Ramot At Tel Aviv University, Ltd. | Ras antagonists for treating neurodegenerative disorders |
| WO2005018562A2 (en) * | 2003-08-22 | 2005-03-03 | University Of Virginia Patent Foundation | Blockade of mtor to prevent a hormonal adaptive response |
| US20050216049A1 (en) * | 2004-03-29 | 2005-09-29 | Jones Donald K | Vascular occlusive device with elastomeric bioresorbable coating |
| US7416757B2 (en) * | 2004-04-08 | 2008-08-26 | Cordis Neurovascular, Inc. | Method of making active embolic coil |
| US8338648B2 (en) * | 2004-06-12 | 2012-12-25 | Signum Biosciences, Inc. | Topical compositions and methods for epithelial-related conditions |
| EP2301528B1 (en) * | 2004-08-18 | 2013-04-03 | Kadmon Corporation, LLC | Use of FTS for treating malignant disorders |
| US7923041B2 (en) | 2005-02-03 | 2011-04-12 | Signum Biosciences, Inc. | Compositions and methods for enhancing cognitive function |
| EP1843734A4 (en) | 2005-02-03 | 2008-09-10 | Signum Biosciences Inc | COMPOSITIONS AND METHOD FOR INTENSIFYING COGNITIVE FUNCTIONS |
| US8278349B2 (en) * | 2005-11-28 | 2012-10-02 | Ramot At Tel-Aviv University Ltd. | Cancer treatment using FTS and 2-deoxyglucose |
| MX2008013017A (es) * | 2006-04-11 | 2008-11-27 | Univ Ramot | Tratamiento de malignidades hematologicas con fts y un inhibidor de tirosina cinasa de bcr-abl. |
| WO2008126094A1 (en) * | 2007-04-17 | 2008-10-23 | Ramot At Tel Aviv University Ltd. | Treatment of myocarditis using fts |
| US20130035390A1 (en) * | 2010-01-13 | 2013-02-07 | Ramot At Tel-Aviv University Ltd. | Treatment of multiple sclerosis |
| WO2012104846A1 (en) * | 2011-01-07 | 2012-08-09 | Ramot At Tel-Aviv University Ltd. | Ras inhibitors for treating diseases or pathological conditions characterized insulin resistance |
| CN103906518B (zh) * | 2011-10-07 | 2020-03-13 | 派西斯治疗有限责任公司 | 使用ras拮抗剂的恶性的和非恶性的疾病治疗 |
| US9738614B2 (en) | 2011-10-07 | 2017-08-22 | Pisces Therapeutics, Llc | Malignant and non-malignant disease treatment with Ras antagonists |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994028009A1 (en) | 1993-06-01 | 1994-12-08 | Ludwig Institute For Cancer Research | Fragments of neurofibromin (nf1) and method to reverse activated ras induced malignant transformation in mammalian cells |
| IL107587A (en) * | 1993-11-12 | 1998-08-16 | Univ Ramot | Farnesyl geranyl or geranyl-geranyl derivatives pharmaceutical compositions containing them and methods for their preparation |
| US6011029A (en) * | 1996-02-26 | 2000-01-04 | Bristol-Myers Squibb Company | Inhibitors of farnesyl protein transferase |
| WO1998002436A1 (en) * | 1996-07-15 | 1998-01-22 | Bristol-Myers Squibb Company | Thiadioxobenzodiazepine inhibitors of farnesyl protein transferase |
| DE19644422C2 (de) * | 1996-10-25 | 2000-06-15 | Stefan Schulz | Verwendung von Terpenen zur Behandlung von Autoimmunkrankheiten und bei Transplantat-Abstoßungsreaktionen |
| AU9315698A (en) * | 1997-09-11 | 1999-03-29 | Beth Israel Deaconess Medical Center | (rin2), a novel inhibitor of ras-mediated signaling |
| EP1027042A4 (en) * | 1997-09-29 | 2004-08-18 | Bristol Myers Squibb Co | FARNESYL PROTEIN TRANSFERASE INHIBITORS |
-
2000
- 2000-06-19 AU AU54970/00A patent/AU5497000A/en not_active Abandoned
- 2000-06-19 CA CA002377254A patent/CA2377254C/en not_active Expired - Fee Related
- 2000-06-19 WO PCT/US2000/016863 patent/WO2000078303A1/en not_active Ceased
- 2000-06-19 JP JP2001504367A patent/JP2003502365A/ja active Pending
- 2000-06-19 EP EP00939967A patent/EP1187605A4/en not_active Ceased
- 2000-06-19 US US09/597,332 patent/US6462086B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU5497000A (en) | 2001-01-09 |
| EP1187605A1 (en) | 2002-03-20 |
| JP2003502365A (ja) | 2003-01-21 |
| US6462086B1 (en) | 2002-10-08 |
| EP1187605A4 (en) | 2004-05-26 |
| WO2000078303A1 (en) | 2000-12-28 |
| CA2377254A1 (en) | 2000-12-28 |
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| MKLA | Lapsed |