CA2377084A1 - Procedes et compositions pour la mise au point de vaccins attenues - Google Patents
Procedes et compositions pour la mise au point de vaccins attenues Download PDFInfo
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- CA2377084A1 CA2377084A1 CA002377084A CA2377084A CA2377084A1 CA 2377084 A1 CA2377084 A1 CA 2377084A1 CA 002377084 A CA002377084 A CA 002377084A CA 2377084 A CA2377084 A CA 2377084A CA 2377084 A1 CA2377084 A1 CA 2377084A1
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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Abstract
Cette invention porte sur des vaccins atténués et sur des procédés visant à obtenir ces vaccins. Les vaccins de cette invention comprennent des parasites bactériens et viraux de recombinaison et autres organismes qui sont mis au point de façon à être fortement atténués sans que le vaccin perde son efficacité. Ces procédés consistent à créer des bibliothèques d'acides nucléiques de recombinaison (à savoir, des génomes entiers ou partiels, ou en particulier des acides nucléiques) qui sont introduits dans les virus ou autres organismes composant le vaccin, puis à rechercher systématiquement et/ou sélectionner ces virus ou organismes qui ont été atténués.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/344,655 | 1999-06-25 | ||
US09/344,655 US6121736A (en) | 1998-07-10 | 1999-06-25 | Control apparatus for motor, and motor unit having the control apparatus |
PCT/US2000/016984 WO2001000234A2 (fr) | 1999-06-25 | 2000-06-20 | Procedes et compositions pour la mise au point de vaccins attenues |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2377084A1 true CA2377084A1 (fr) | 2001-01-04 |
Family
ID=23351426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002377084A Abandoned CA2377084A1 (fr) | 1999-06-25 | 2000-06-20 | Procedes et compositions pour la mise au point de vaccins attenues |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1196552A2 (fr) |
JP (1) | JP2003503039A (fr) |
AU (1) | AU5880900A (fr) |
CA (1) | CA2377084A1 (fr) |
WO (1) | WO2001000234A2 (fr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6764835B2 (en) | 1995-12-07 | 2004-07-20 | Diversa Corporation | Saturation mutageneis in directed evolution |
US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
EP2471938A3 (fr) * | 2005-11-24 | 2013-04-24 | The Research Foundation for Microbial Diseases of Osaka University | Vaccin polyvalent recombiné |
ES2660000T3 (es) | 2008-09-26 | 2018-03-20 | Ambrx, Inc. | Vacunas y microorganismos dependientes de la replicación de aminoácidos no naturales |
CA2800824A1 (fr) | 2010-06-02 | 2011-12-08 | Virginia Tech Intellectual Properties, Inc. | Vaccins vivants attenues inedits et vaccins sous-unitaires crees par recombinaison aleatoire de l'adn (« dna shuffling ») contre le virus du syndrome reproducteur et respiratoireporcin (vsrrp) |
US20150306209A1 (en) * | 2012-12-19 | 2015-10-29 | Intervet Inc. | CANINE PARVOVIRUS TYPE 2c ISOLATES AND METHODS OF USE |
JP2014236748A (ja) * | 2014-08-26 | 2014-12-18 | 一般財団法人阪大微生物病研究会 | 組換え多価ワクチン |
JP7053488B2 (ja) * | 2016-04-26 | 2022-04-12 | ロンドン スクール オブ ハイジーン アンド トロピカル メディシン | レオウイルス科ワクチン |
US10174295B1 (en) * | 2017-08-01 | 2019-01-08 | The Charles Stark Draper Laboratory, Inc. | Composition of matter: engineering of Escherichia coli phage K1E |
CN108641993A (zh) * | 2018-05-17 | 2018-10-12 | 新疆农垦科学院 | 一种食品级表达牛病毒性腹泻病毒e2蛋白的重组乳酸菌口服疫苗株 |
MX2021004907A (es) * | 2018-10-31 | 2021-06-15 | Boehringer Ingelheim Vetmedica Gmbh | Vacuna de ibv 4/91 con proteina espicular heterologa. |
CN110184242B (zh) * | 2019-06-11 | 2021-08-20 | 武汉生物制品研究所有限责任公司 | 柯萨奇病毒a组6型(cva6)的小鼠强毒力攻毒株及其应用 |
GB202009701D0 (en) * | 2020-06-25 | 2020-08-12 | Theolytics Ltd | Generation of diverse viral libraries |
CN113061581A (zh) * | 2021-03-22 | 2021-07-02 | 华中农业大学 | 一种山羊源牛疱疹病毒1型毒株及其应用 |
CN116036253B (zh) * | 2022-11-24 | 2023-12-26 | 畜科生物工程有限公司 | 一种猪繁殖与呼吸综合征活疫苗及其制备方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6117679A (en) * | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
WO1999023107A1 (fr) * | 1997-10-31 | 1999-05-14 | Maxygen, Incorporated | Modification du tropisme viral et de la diversite d'especes hote par recombinaison du genome viral |
-
2000
- 2000-06-20 EP EP00944760A patent/EP1196552A2/fr not_active Withdrawn
- 2000-06-20 JP JP2001505941A patent/JP2003503039A/ja not_active Withdrawn
- 2000-06-20 CA CA002377084A patent/CA2377084A1/fr not_active Abandoned
- 2000-06-20 WO PCT/US2000/016984 patent/WO2001000234A2/fr not_active Application Discontinuation
- 2000-06-20 AU AU58809/00A patent/AU5880900A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU5880900A (en) | 2001-01-31 |
WO2001000234A2 (fr) | 2001-01-04 |
EP1196552A2 (fr) | 2002-04-17 |
JP2003503039A (ja) | 2003-01-28 |
WO2001000234A3 (fr) | 2001-08-02 |
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