CA2376420A1 - Statine-derived tetrapeptide inhibitors of beta-secretase - Google Patents

Statine-derived tetrapeptide inhibitors of beta-secretase Download PDF

Info

Publication number
CA2376420A1
CA2376420A1 CA002376420A CA2376420A CA2376420A1 CA 2376420 A1 CA2376420 A1 CA 2376420A1 CA 002376420 A CA002376420 A CA 002376420A CA 2376420 A CA2376420 A CA 2376420A CA 2376420 A1 CA2376420 A1 CA 2376420A1
Authority
CA
Canada
Prior art keywords
group
acid
phenyl
propyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002376420A
Other languages
English (en)
French (fr)
Inventor
Varghese John
Jay Tung
Lawrence Fang
Shumeye S. Mamo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2376420A1 publication Critical patent/CA2376420A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002376420A 1999-06-15 2000-06-15 Statine-derived tetrapeptide inhibitors of beta-secretase Abandoned CA2376420A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13917399P 1999-06-15 1999-06-15
US60/139,173 1999-06-15
PCT/US2000/016643 WO2000077030A1 (en) 1999-06-15 2000-06-15 Statine-derived tetrapeptide inhibitors of beta-secretase

Publications (1)

Publication Number Publication Date
CA2376420A1 true CA2376420A1 (en) 2000-12-21

Family

ID=22485425

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002376420A Abandoned CA2376420A1 (en) 1999-06-15 2000-06-15 Statine-derived tetrapeptide inhibitors of beta-secretase

Country Status (5)

Country Link
EP (1) EP1192177A1 (de)
JP (1) JP2003502342A (de)
AU (1) AU5619400A (de)
CA (1) CA2376420A1 (de)
WO (1) WO2000077030A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6545127B1 (en) 1999-06-28 2003-04-08 Oklahoma Medical Research Foundation Catalytically active recombinant memapsin and methods of use thereof
EP1666452A2 (de) 2000-06-30 2006-06-07 Elan Pharmaceuticals, Inc. Verbindungen zur Behandlung der Alzheimerischen Krankheit
CA2450202A1 (en) * 2001-06-12 2002-12-19 Elan Pharmaceuticals, Inc. Macrocycles useful in the treatment of alzheimer's disease
MXPA04000328A (es) 2001-07-10 2004-07-23 Pharmacia & Upjohn Comapny Derivados de alfa-hidroxiamida estatina para tratamiento de enfermedad de alzheimer.
JP4547152B2 (ja) 2001-10-23 2010-09-22 オクラホマ メディカル リサーチ ファウンデーション β−セクレターゼ阻害剤および使用方法
JP2005511735A (ja) 2001-12-06 2005-04-28 イーラン ファーマスーティカルズ、インコーポレイテッド 置換ヒドロキシエチルアミン
EP1458745A2 (de) 2002-01-04 2004-09-22 Elan Pharmaceuticals, Inc. Substituierte aminocarboxamide zur behandlung der alzheimerschen krankheit
WO2003094854A2 (en) 2002-05-07 2003-11-20 Elan Pharmaceuticals, Inc. Succinoyl aminopyrazoles and related compounds
US7557137B2 (en) * 2002-08-05 2009-07-07 Bristol-Myers Squibb Company Gamma-lactams as beta-secretase inhibitors
CA2507484A1 (en) 2002-11-27 2004-06-17 Elan Pharmaceuticals, Inc. Substituted ureas and carbamates
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
CA2515975C (en) 2003-02-28 2013-02-05 Yoshiaki Kiso Peptide derivatives having .beta.-secretase inhibitory activity
US20050090449A1 (en) * 2003-05-13 2005-04-28 Boehringer Ingelheim International Gmbh Novel statine derivatives for the treatment of Alzheimer's disease
EP1633350B1 (de) 2003-06-05 2012-10-03 Elan Pharmaceuticals, Inc. Acylierte aminosäure-amidyl-pyrazole und verwandte verbindungen
WO2006050862A1 (en) * 2004-11-10 2006-05-18 Boehringer Ingelheim International Gmbh Statine derivatives for the treatment of alzheimer's disease
WO2006050861A2 (en) * 2004-11-10 2006-05-18 Boehringer Ingelheim International Gmbh Statine derivatives for the treatment of alzheimer's disease
TW200815349A (en) 2006-06-22 2008-04-01 Astrazeneca Ab New compounds
CN101348456B (zh) * 2007-07-17 2011-05-11 中国科学院上海药物研究所 苄基哌啶类化合物及其制备方法和用途
TW201020244A (en) 2008-11-14 2010-06-01 Astrazeneca Ab New compounds
EP2281824A1 (de) 2009-08-07 2011-02-09 Noscira, S.A. Furan-Imidazolon-Derivate zur Behandlung von kognitiven, neurodegenerativen oder neuronalen Erkrankungen oder Funktionsstörungen
EP2643299B1 (de) 2010-11-22 2016-06-22 Noscira, S.A. Bipyridinsulfonamidderivate zur behandlung von neurodegenerativen erkrankungen oder zuständen

Also Published As

Publication number Publication date
JP2003502342A (ja) 2003-01-21
EP1192177A1 (de) 2002-04-03
AU5619400A (en) 2001-01-02
WO2000077030A1 (en) 2000-12-21

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