CA2374209A1 - Utilisations therapeutiques d'inhibiteurs d'oxyde nitrique - Google Patents
Utilisations therapeutiques d'inhibiteurs d'oxyde nitrique Download PDFInfo
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- CA2374209A1 CA2374209A1 CA002374209A CA2374209A CA2374209A1 CA 2374209 A1 CA2374209 A1 CA 2374209A1 CA 002374209 A CA002374209 A CA 002374209A CA 2374209 A CA2374209 A CA 2374209A CA 2374209 A1 CA2374209 A1 CA 2374209A1
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- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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- A61K31/13—Amines
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- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Abstract
L'oxyde nitrique (NO) constitue un important régulateur de croissance dans un organisme en développement intact. Cette invention se rapporte à un procédé permettant d'accroître chez un mammifère la population de cellules souches hématopoïétiques qui sont capables de subir une hématopoïèse, une différenciation et une maturation normales du tissu hématopoïétique, lequel est mis en contact avec des doses multiples d'au moins un inhibiteur de NO, tel que des inhibiteurs d'oxyde nitrique synthase (NOS). Cette invention se rapporte également à un procédé qui sert à augmenter la population de cellules en phase S dans un tissu d'un mammifère et consistant à cet effet à mettre en contact le tissu avec des doses multiples d'au moins un inhibiteur de NO, tel qu'un inhibiteur de NOS. Cette invention concerne en outre un procédé servant à régénérer des tissus chez un mammifère adulte et consistant à mettre en contact un tissu sélectionné (par exemple sang, peau, os et épithélium digestif) ou des cellules précurseurs, avec des doses multiples d'au moins un inhibiteur de NO, qui inhibe la différenciation et induit la prolifération de cellules de ce tissu.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/315,929 US6372796B1 (en) | 1996-11-13 | 1999-05-20 | Therapeutic uses for nitric oxide inhibitors |
| US09/315,929 | 1999-05-20 | ||
| PCT/US2000/013685 WO2000071112A1 (fr) | 1997-11-13 | 2000-05-18 | Utilisations therapeutiques d'inhibiteurs d'oxyde nitrique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2374209A1 true CA2374209A1 (fr) | 2000-11-30 |
Family
ID=23226694
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002374209A Abandoned CA2374209A1 (fr) | 1999-05-20 | 2000-05-18 | Utilisations therapeutiques d'inhibiteurs d'oxyde nitrique |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1185258A1 (fr) |
| JP (1) | JP2003500355A (fr) |
| AU (1) | AU5275200A (fr) |
| CA (1) | CA2374209A1 (fr) |
| WO (1) | WO2000071112A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201406116RA (en) * | 2009-09-29 | 2014-11-27 | Dart Neuroscience Cayman Ltd | Genes, methods, and compositions related to neurogenesis and its modulation |
| CN116947976B (zh) * | 2023-07-27 | 2024-01-09 | 重庆市铂而斐细胞生物技术有限公司 | 一种间充质干细胞治疗软骨损伤的方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998020865A2 (fr) * | 1996-11-13 | 1998-05-22 | Cold Spring Harbor Laboratory | Utilisations therapeutiques d'inhibiteurs d'oxyde nitrique |
-
2000
- 2000-05-18 AU AU52752/00A patent/AU5275200A/en not_active Abandoned
- 2000-05-18 CA CA002374209A patent/CA2374209A1/fr not_active Abandoned
- 2000-05-18 JP JP2000619419A patent/JP2003500355A/ja active Pending
- 2000-05-18 WO PCT/US2000/013685 patent/WO2000071112A1/fr active Application Filing
- 2000-05-18 EP EP00937605A patent/EP1185258A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003500355A (ja) | 2003-01-07 |
| EP1185258A1 (fr) | 2002-03-13 |
| AU5275200A (en) | 2000-12-12 |
| WO2000071112A1 (fr) | 2000-11-30 |
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