CA2373276C - Substrate sections with improved storage stability during their storage in bags, and a method for producing the same - Google Patents
Substrate sections with improved storage stability during their storage in bags, and a method for producing the same Download PDFInfo
- Publication number
- CA2373276C CA2373276C CA002373276A CA2373276A CA2373276C CA 2373276 C CA2373276 C CA 2373276C CA 002373276 A CA002373276 A CA 002373276A CA 2373276 A CA2373276 A CA 2373276A CA 2373276 C CA2373276 C CA 2373276C
- Authority
- CA
- Canada
- Prior art keywords
- carrier layer
- sections
- pressure
- sensitive adhesive
- substrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000758 substrate Substances 0.000 title claims abstract description 31
- 238000003860 storage Methods 0.000 title claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 title description 4
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 22
- 239000010410 layer Substances 0.000 claims description 40
- 239000011159 matrix material Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 3
- 239000000853 adhesive Substances 0.000 abstract description 8
- 230000001070 adhesive effect Effects 0.000 abstract description 8
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000013543 active substance Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000004520 agglutination Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000005022 packaging material Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
- A61M35/006—Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
- A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Preparation (AREA)
- Bag Frames (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Adhesive Tapes (AREA)
- Packages (AREA)
- Supplying Of Containers To The Packaging Station (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention relates to substrate sections provided with a pressure-sensitive adhesive surface which are sealed in bags to protect against degradation of the active ingredients. The pressure-sensitive adhesive surface is covered by a carrier layer which at least partially projects further than said adhesive surface. The carrier layer is subdivided by an incision which forms a removal aid. During storage, adhesive in cold flow can escape through this incision, causing adhesion to the bag. Said substrate sections are characterised in that the carrier layer is configured as two carrier-layer sections (2, 3) which overlap in their adjoining areas (4), in order to improve storage stability by preventing the adhesive from escaping.
Description
The invention relates to substrate sections which have been rendered pressure-sensitive adhesive and are sealed in bags so as to be protected against loss of active substance, the pressure-sensitive adhesive surface of which is covered by a carrier layer which at least partially projects beyond the said substrate sections and is divided by an incision, thus forming a release aid, through which incision pres-sure-sensitive adhesive may leak out in cold flow during storage and may cause agglutination with the bag.
it is known how to manufacture and use flat-shaped pres-sure-sensitive adhesive substrate sections. These may be, for example, active substance-containing transdermal therapeutic systems. if such systems contain volatile components, for example as active agents, there results the necessity of protecting the substrate sections which have been provided with these components against evaporation of the volatile components during the time span between manufacture and use, that is, during their storage up to their application.
This is achieved, for example, by providing the pressure-sensitive adhesive substrate sections with a detachable carrier layer so as to protect their pressure-sensitive adhesive surface and subsequently sealing the sections in a bag surrounding the same on all sides. Here it is con-venient for the carrier layer to project beyond the pres-sure-sensitive adhesive surface of a substrate section so as to, on the one hand, facilitate the peeling of the carrier layer off the substrate layer prior to use, and, on the other hand, prevent the substrate sections from sticking to the package surfaces as a result of pressure-sensitive adhaolva material leaking in co].d flow. when the packags is open only at one side, such sticking would make removixig the laminate more dif f icult or evon render it impossible.
To olimf.nate this problem, it has already been proposed to provide an incision in the detachable carrier layer, which results in easier detachment of the carrier layer and enablas application of the pressure-sensitive adhesive substrate sections to the site of application in a patient.
A disadvantage of this measure raxuits from the fact that during storage of the packaged substrate sections it is still possible for the pressure-senaitive adhesive to leak out at the cutting edge of the detachable carrier layer by way of cold flow, it may thus cause extremely dieadvatstiage-ous sticking of the sections to the aurfaces of the package, so that e,vitbdrawing the laminate from a package which is open at one side is made even more difficult or impossible.
It i.a the object of the presant invention to provide, =in a substrate section of the kind mentioned as defined herein, an embcdimer-t of the carrier layer provided with a releasing aid, by means of which embodiment the leaking-out of pressure-aensitive adhesive in cold flow caa be prevented easiZy,and with simple means, thus facili-tating easy withdxawzll of substrate aeations from a package which is open oaly at one side.
'1'his object is achieved by the invention in a substrate section of the kind mentioried at the beginning hereof by the fact that to incraaae the storage stability the carrier layer is configured with two carrier layer sections which overlap each other*ia the area where they are joined together, prevent3.ng the leaking-out of adhesive.
.
=
it is known how to manufacture and use flat-shaped pres-sure-sensitive adhesive substrate sections. These may be, for example, active substance-containing transdermal therapeutic systems. if such systems contain volatile components, for example as active agents, there results the necessity of protecting the substrate sections which have been provided with these components against evaporation of the volatile components during the time span between manufacture and use, that is, during their storage up to their application.
This is achieved, for example, by providing the pressure-sensitive adhesive substrate sections with a detachable carrier layer so as to protect their pressure-sensitive adhesive surface and subsequently sealing the sections in a bag surrounding the same on all sides. Here it is con-venient for the carrier layer to project beyond the pres-sure-sensitive adhesive surface of a substrate section so as to, on the one hand, facilitate the peeling of the carrier layer off the substrate layer prior to use, and, on the other hand, prevent the substrate sections from sticking to the package surfaces as a result of pressure-sensitive adhaolva material leaking in co].d flow. when the packags is open only at one side, such sticking would make removixig the laminate more dif f icult or evon render it impossible.
To olimf.nate this problem, it has already been proposed to provide an incision in the detachable carrier layer, which results in easier detachment of the carrier layer and enablas application of the pressure-sensitive adhesive substrate sections to the site of application in a patient.
A disadvantage of this measure raxuits from the fact that during storage of the packaged substrate sections it is still possible for the pressure-senaitive adhesive to leak out at the cutting edge of the detachable carrier layer by way of cold flow, it may thus cause extremely dieadvatstiage-ous sticking of the sections to the aurfaces of the package, so that e,vitbdrawing the laminate from a package which is open at one side is made even more difficult or impossible.
It i.a the object of the presant invention to provide, =in a substrate section of the kind mentioned as defined herein, an embcdimer-t of the carrier layer provided with a releasing aid, by means of which embodiment the leaking-out of pressure-aensitive adhesive in cold flow caa be prevented easiZy,and with simple means, thus facili-tating easy withdxawzll of substrate aeations from a package which is open oaly at one side.
'1'his object is achieved by the invention in a substrate section of the kind mentioried at the beginning hereof by the fact that to incraaae the storage stability the carrier layer is configured with two carrier layer sections which overlap each other*ia the area where they are joined together, prevent3.ng the leaking-out of adhesive.
.
=
To great advantage, by means of this surprisingly simple embodiment of the carrier layer, the leakage of adhesive and thus any sticking to the packaging material is pre-vented, and the removal of the laminate when the package is open only at one side is facilitated without difficulty, while the detachability of the carrier layer from the substrate section remains undiminished.
A process for forming substrate sections comprising carrier layer sections, which carrier layer sections project beyond the said substrate sections and form a region of overlap, is characterized in that the said carrier layer sections are supplied with the pressure-sensitive adhesive substrate sections via a dispensing process, for example, according to WO 92/17237, after the carrier layer sections have been overlapped.
Further details, features and advantages of the invention will become apparent from the following explanation of an embodiment example represented schematically in the drawing.
Fig. 1 shows the substrate layer 1 in cross-section, comprising a backing layer 5 and a matrix 6 connected thereto. Said matrix may either be comprised entirely of a pressure-sensitive adhesive material or be rendered pressure-sensitive adhesive on its application surface by providing it with a pressure-sensitive adhesive layer (not shown). The pressure-sensitive adhesive surface or the pressure sensitive adhesive-rendered matrix 6, respective-ly, is covered by a carrier layer which projects beyond said matrix 6 at least partially and which according to the invention is configured with two carrier layer sections 2,3 which overlap each other in the region where they are joined.
Due to the fact that the carrier layer sections 2, 3 project beyond the matrix 6 at the side edges 7, 8 in a manner known per se, in the possible case of adhesive leaking out, any sticking to the package bag is reliably prevented.
On account of the fact that the carrier layer 2,3, which is assembled in two parts for reasons of better detachability, is configured with a region of overlap 4, the said carrier layer prevents, also in this region, the leaking-out of pressure-sensitive adhesive in cold flow during a prolonged storage.
One embodiment provides for one of the carrier layer sections 2 to be wider than the other section 3 by the amount of the overlap 4.
However, one may also take the measure of configuring both carrier layer sections 2, 3 to be wider, by an amount of half of the overlap, than half the width dimension of an undivided carrier layer 1.
Furthermore the region of overlap 4 may be placed either centrally or eccentrically on the substrate section 1, without diminishing its function as a detachment aid. This measure facilitates manufacture and its control.
A process for forming substrate sections 1 comprising carrier layer sections 2, 3 which project beyond the said substrate sections and form a region of overlap 4 is characterized in that the carrier layer sections 2, 3 are supplied with the pressure-sensitive adhesive substrate sections 1 after the said carrier layer sections 2, 3 have been overlapped.
The solution according to the present invention is surprisingly simple and optimally solves the task posed at the beginning hereof.
A process for forming substrate sections comprising carrier layer sections, which carrier layer sections project beyond the said substrate sections and form a region of overlap, is characterized in that the said carrier layer sections are supplied with the pressure-sensitive adhesive substrate sections via a dispensing process, for example, according to WO 92/17237, after the carrier layer sections have been overlapped.
Further details, features and advantages of the invention will become apparent from the following explanation of an embodiment example represented schematically in the drawing.
Fig. 1 shows the substrate layer 1 in cross-section, comprising a backing layer 5 and a matrix 6 connected thereto. Said matrix may either be comprised entirely of a pressure-sensitive adhesive material or be rendered pressure-sensitive adhesive on its application surface by providing it with a pressure-sensitive adhesive layer (not shown). The pressure-sensitive adhesive surface or the pressure sensitive adhesive-rendered matrix 6, respective-ly, is covered by a carrier layer which projects beyond said matrix 6 at least partially and which according to the invention is configured with two carrier layer sections 2,3 which overlap each other in the region where they are joined.
Due to the fact that the carrier layer sections 2, 3 project beyond the matrix 6 at the side edges 7, 8 in a manner known per se, in the possible case of adhesive leaking out, any sticking to the package bag is reliably prevented.
On account of the fact that the carrier layer 2,3, which is assembled in two parts for reasons of better detachability, is configured with a region of overlap 4, the said carrier layer prevents, also in this region, the leaking-out of pressure-sensitive adhesive in cold flow during a prolonged storage.
One embodiment provides for one of the carrier layer sections 2 to be wider than the other section 3 by the amount of the overlap 4.
However, one may also take the measure of configuring both carrier layer sections 2, 3 to be wider, by an amount of half of the overlap, than half the width dimension of an undivided carrier layer 1.
Furthermore the region of overlap 4 may be placed either centrally or eccentrically on the substrate section 1, without diminishing its function as a detachment aid. This measure facilitates manufacture and its control.
A process for forming substrate sections 1 comprising carrier layer sections 2, 3 which project beyond the said substrate sections and form a region of overlap 4 is characterized in that the carrier layer sections 2, 3 are supplied with the pressure-sensitive adhesive substrate sections 1 after the said carrier layer sections 2, 3 have been overlapped.
The solution according to the present invention is surprisingly simple and optimally solves the task posed at the beginning hereof.
Claims (4)
1. A substrate section which is sealed in a bag, comprising a backing layer and a matrix which is connected with said backing layer and is comprised entirely of a pressure-sensitive adhesive material or has been rendered pressure-sensitive adhesive on its application surface by providing said surface with a pressure-sensitive adhesive layer, the pressure-sensitive adhesive surface of said matrix being covered by a carrier layer which projects at least partially beyond said substrate sections and is divided by an Incision, wherein to increase storage stability by avoiding leakage of pressure-sensitive adhesive, the carrier layer is configured with two carrier layer sections which overlap each other In the region where they are joined.
2. The substrate section according to Claim 1, wherein one of the carrier layer sections Is wider than the other section by the amount of the overlap.
3. The substrate section according to Claim 1, wherein both carrier layer sections are, by the amount of half the overlap, wider than half the width dimension of an undivided carrier layer.
4. The substrate section according to any one of Claims 1 to 3, wherein the region of overlap is positioned centrally or eccentrically on the substrate section.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19925338.2 | 1999-06-02 | ||
| DE19925338A DE19925338A1 (en) | 1999-06-02 | 1999-06-02 | Substrate sections with increased storage stability during their storage in pouch packaging, and methods for their production |
| PCT/EP2000/004588 WO2000074660A2 (en) | 1999-06-02 | 2000-05-20 | Substrate sections with improved storage stability during their storage in bags, and a method for producing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2373276A1 CA2373276A1 (en) | 2000-12-14 |
| CA2373276C true CA2373276C (en) | 2008-07-15 |
Family
ID=7910056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002373276A Expired - Lifetime CA2373276C (en) | 1999-06-02 | 2000-05-20 | Substrate sections with improved storage stability during their storage in bags, and a method for producing the same |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1180023B1 (en) |
| JP (2) | JP5565890B2 (en) |
| KR (1) | KR100599235B1 (en) |
| AT (1) | ATE283690T1 (en) |
| AU (1) | AU4758200A (en) |
| CA (1) | CA2373276C (en) |
| DE (2) | DE19925338A1 (en) |
| ES (1) | ES2233374T3 (en) |
| IL (2) | IL146820A0 (en) |
| WO (1) | WO2000074660A2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007025973A1 (en) | 2007-06-04 | 2008-12-11 | Lts Lohmann Therapie-Systeme Ag | Storage stable laminate sections |
| DE102010000661A1 (en) * | 2010-01-04 | 2011-07-07 | Acino Ag, 83714 | Method and device for producing an overlapping protective film for a transdermal therapeutic system |
| DE102011080390B3 (en) | 2011-08-03 | 2012-07-12 | Acino Ag | application aid |
| DE102013008726A1 (en) | 2013-05-23 | 2014-11-27 | Amw Gmbh | Plaster with removal aid |
| DE102013008727A1 (en) | 2013-05-23 | 2014-11-27 | Amw Gmbh | Plaster with notched peel-off film |
| CN106572981B (en) | 2014-07-04 | 2020-03-03 | 绿叶制药股份公司 | Apparatus for manufacturing drug patch |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4613598Y1 (en) * | 1968-12-10 | 1971-05-14 | ||
| JPS521877U (en) * | 1975-06-24 | 1977-01-07 | ||
| NO821782L (en) * | 1981-06-04 | 1982-12-06 | John Michael Simpson | SURGICAL PLASTER. |
| DE3810658A1 (en) * | 1988-03-29 | 1989-10-12 | Lohmann Gmbh & Co Kg | PLASTER, ESPECIALLY EPIKUTANT TEST PLASTER AND METHOD FOR PRODUCING THE SAME |
| JPH0451782Y2 (en) * | 1988-04-16 | 1992-12-07 | ||
| NO894195L (en) * | 1989-06-05 | 1990-12-06 | Bertek Inc | DEVICE FOR APPLICATION OF A THIN FILM. |
| US5124157A (en) * | 1989-08-18 | 1992-06-23 | Cygnus Therapeutic Systems | Method and device for administering dexmedetomidine transdermally |
| US5202125A (en) * | 1990-12-10 | 1993-04-13 | Theratech, Inc. | Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes |
| DE4110027C2 (en) * | 1991-03-27 | 1996-08-29 | Lohmann Therapie Syst Lts | Process for packaging transdermal therapeutic patches |
| SE9501670L (en) * | 1995-05-05 | 1996-06-10 | Perstorp Ab | Omläggningsset |
| JP2791317B2 (en) * | 1995-12-26 | 1998-08-27 | 株式会社三和化学研究所 | Multilayer film preparation |
| US5829442A (en) * | 1996-06-12 | 1998-11-03 | Medical Concepts Development, Inc. | Antimicrobial containing solventless hot melt adhesive composition |
| DE19650329A1 (en) * | 1996-12-04 | 1998-06-10 | Hexal Ag | Flat self-adhesive active ingredient plaster |
| DE19706824C1 (en) * | 1997-02-21 | 1998-03-26 | Lohmann Therapie Syst Lts | Plaster for transdermal drug delivery |
-
1999
- 1999-06-02 DE DE19925338A patent/DE19925338A1/en not_active Withdrawn
-
2000
- 2000-05-20 KR KR1020017015502A patent/KR100599235B1/en active IP Right Grant
- 2000-05-20 WO PCT/EP2000/004588 patent/WO2000074660A2/en active IP Right Grant
- 2000-05-20 IL IL14682000A patent/IL146820A0/en active IP Right Grant
- 2000-05-20 JP JP2001501197A patent/JP5565890B2/en not_active Expired - Lifetime
- 2000-05-20 AU AU47582/00A patent/AU4758200A/en not_active Abandoned
- 2000-05-20 DE DE50008843T patent/DE50008843D1/en not_active Expired - Lifetime
- 2000-05-20 CA CA002373276A patent/CA2373276C/en not_active Expired - Lifetime
- 2000-05-20 ES ES00929544T patent/ES2233374T3/en not_active Expired - Lifetime
- 2000-05-20 AT AT00929544T patent/ATE283690T1/en not_active IP Right Cessation
- 2000-05-20 EP EP00929544A patent/EP1180023B1/en not_active Expired - Lifetime
-
2001
- 2001-11-29 IL IL146820A patent/IL146820A/en not_active IP Right Cessation
-
2011
- 2011-12-28 JP JP2011287161A patent/JP5554317B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL146820A (en) | 2006-08-20 |
| EP1180023A2 (en) | 2002-02-20 |
| KR20020012589A (en) | 2002-02-16 |
| DE50008843D1 (en) | 2005-01-05 |
| ATE283690T1 (en) | 2004-12-15 |
| JP2012111949A (en) | 2012-06-14 |
| JP5565890B2 (en) | 2014-08-06 |
| WO2000074660A3 (en) | 2001-06-28 |
| KR100599235B1 (en) | 2006-07-13 |
| JP2003501380A (en) | 2003-01-14 |
| IL146820A0 (en) | 2002-07-25 |
| ES2233374T3 (en) | 2005-06-16 |
| WO2000074660A2 (en) | 2000-12-14 |
| AU4758200A (en) | 2000-12-28 |
| EP1180023B1 (en) | 2004-12-01 |
| JP5554317B2 (en) | 2014-07-23 |
| DE19925338A1 (en) | 2000-12-07 |
| CA2373276A1 (en) | 2000-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20200520 |