IL146820A

IL146820A - Substrate sections with improved storage stability during their storage in bags, and a method for producing the same

Info

Publication number: IL146820A
Application number: IL146820A
Authority: IL
Original assignee: Lohmann Therapie Syst Lts
Priority date: 1999-06-02
Filing date: 2001-11-29
Publication date: 2006-08-20
Also published as: KR100599235B1; WO2000074660A2; AU4758200A; ATE283690T1; JP2003501380A; EP1180023B1; JP5565890B2; CA2373276C; EP1180023A2; ES2233374T3; DE50008843D1; JP5554317B2; KR20020012589A; IL146820A0; DE19925338A1; CA2373276A1; JP2012111949A; WO2000074660A3

Abstract

The invention relates to substrate sections provided with a pressure-sensitive adhesive surface which are sealed in bags to protect against degradation of the active ingredients. The pressure-sensitive adhesive surface is covered by a carrier layer which at least partially projects further than said adhesive surface. The carrier layer is subdivided by an incision which forms a removal aid. During storage, adhesive in cold flow can escape through this incision, causing adhesion to the bag. Said substrate sections are characterised in that the carrier layer is configured as two carrier-layer sections (2, 3) which overlap in their adjoining areas (4), in order to improve storage stability by preventing the adhesive from escaping.

Description

13924/01 146820/2 m r"1? ni uji ,ιτρϋπ iurrK mmn maiam IIDTTK mrmj DU macoti 'Ρ^η SUBSTRATE SECTIONS WITH IMPROVED STORAGE STABILITY DURING THEIR STORAGE IN BAGS, AND A METHOD FOR PRODUCING THE SAME The invention relates to substrate sections which have been rendered pressure-sensitive adhesive and are sealed in bags so as to be protected against loss of active substance, the pressure-sensitive adhesive surface of which is covered by a carrier layer which at least partially projects beyond the said substrate sections and is divided by an incision, thus forming a release aid, through which incision pressure-sensitive adhesive may leak out in cold flow during storage and may cause agglutination with the bag.

It is known how to manufacture and use flat-shaped pressure-sensitive adhesive substrate sections. These may be, for example, active substance-containing transdermal therapeutic systems . If such systems contain volatile components, for example as active agents, there results the necessity of protecting the substrate sections which have been provided with these components against evaporation of the volatile components during the time span between manufacture and use, that is, during their storage up to their application.

This is achieved, for example, by providing the pressure-sensitive adhesive substrate sections with a detachable carrier layer so as to protect their pressure-sensitive adhesive surface and subsequently sealing the sections in a bag surrounding the same on all sides. Here it is convenient for the carrier layer to project beyond the pressure-sensitive adhesive surface of a substrate section so as to, on the one hand, facilitate the peeling of the carrier layer off the substrate layer prior to use, and, on the other hand, prevent the substrate sections from sticking to the package surfaces as a result of pressure- sensitive adhesive material leaking in cold flow. When the package is open only at one side, such sticking would make removing the laminate more difficult or even render it impossible.

To eliminate this problem, it has already been proposed to provide an incision in the detachable carrier layer, which results in easier detachment of the carrier layer and enables application of the pressure-sensitive adhesive substrate sections to the site of application in a patient . A disadvantage of this measure results from the fact that during storage of the packaged substrate sections it is still possible for the pressure-sensitive adhesive to leak out at the cutting edge of the detachable carrier layer by way of cold flow, it may thus cause extremely disadvantageous sticking of the sections to the surfaces of the package, so that withdrawing the laminate from a package which is open at one side is made even more difficult or impossible.

It is the object of the present invention to provide, in a substrate section of the kind mentioned in the introductory part of Claim 1, an embodiment of the carrier layer provided with a releasing aid, by means of which embodiment the leaking-out of pressure-sensitive adhesive in cold flow can be prevented easily and with simple means, thus facilitating easy withdrawal of substrate sections from a package which is open only at one side.

This object is achieved by the invention in a substrate section of the kind mentioned at the beginning hereof by the fact that to increase the storage stability the carrier layer is configured with two carrier layer sections which overlap each other in the area where they are joined together, preventing the leaking-out of adhesive.

To great advantage, by means of this surprisingly simple embodiment of the carrier layer, the leakage of adhesive and thus any sticking to the packaging material is prevented, and the removal of the laminate when the package is open only at one side is facilitated without difficulty, while the detachability of the carrier layer from the substrate section remains undiminished.

A process for forming substrate sections comprising carrier layer sections, which carrier layer sections project beyond the said substrate sections and form a region of overlap, is characterized in that the said carrier layer sections are supplied with the pressure-sensitive adhesive substrate sections via a dispensing process, for example, according to WO 92/17237, after the carrier layer sections have been overlapped.

Further details, features and advantages of the invention will become apparent from the following explanation of an embodiment example represented schematically in the drawing.

Fig. 1 shows the substrate layer 1 in cross-section, comprising a backing layer 5 and a matrix 6 connected thereto. Said matrix may either be comprised entirely of a pressure-sensitive adhesive material or be rendered pressure-sensitive adhesive on its application surface by providing it with a pressure-sensitive adhesive layer (not shown) . The pressure-sensitive adhesive surface or the pressure sensitive adhesive-rendered matrix 6, respectively, is covered by a carrier layer which projects beyond said matrix 6 at least partially and which according to the invention is configured with two carrier layer sections 2,3 which overlap each other in the region where they are joined.

Due to the fact that the carrier layer sections 2, 3 project beyond the matrix 6 at the side edges 7, 8 in a maimer known per se, in the possible case of adhesive leaking out, any sticking to the package bag is reliably prevented .

On account of the fact that the carrier layer 2,3, which is assembled in two parts for reasons of better detachabllity, is configured with a region of overlap 4, the said carrier layer prevents, also in this region, the leaking-out of pressure-sensitive adhesive in cold flow during a prolonged storage.

One embodiment provides for one of the carrier layer sections 2 to be wider than the other section 3 by the amount of the overlap 4.

However, one may also take the measure of configuring both carrier layer sections 2, 3 to be wider, by an amount of half of the overlap, than half the width dimension of an undivided carrier layer 1.

Furthermore the region of overlap 4 may be placed either centrally or eccentrically on the substrate section 1, without diminishing its function as a detachment aid. This measure facilitates manufacture and its control .

A process for forming substrate sections 1 comprising carrier layer sections 2, 3 which project beyond the said substrate sections and form a region of overlap 4 is characterized in that the carrier layer sections 2, 3 are supplied with the pressure-sensitive adhesive substrate sections 1 after the said carrier layer sections 2, 3 have been overlapped.

The solution according to the present invention is surprisingly simple and optimally solves the task posed at the beginning hereof.

Claims

5 146820/2 Claims

1. Substrate sections which are sealed in bags so as to be protected against loss of active substance and comprising a backing layer and a matrix which is connected with said backing layer and is comprised entirely of a pressure-sensitive adhesive material or has been rendered pressure-sensitive adhesive on its application surface by providing said surface with a pressure-sensitive adhesive layer, the pressure-sensitive adhesive surface of said matrix being covered by a carrier layer which projects at least partially beyond said substrate sections and is divided by an incision, thus forming a detachment aid, through which incision adhesive may leak out in cold flow during storage and may cause the substrate section to stick to the bag, characterized in that in order to increase storage stability by avoiding leakage of pressure-sensitive adhesive, the carrier layer is configured with two carrier layer sections which overlap each other in the region where they are joined.

2. Substrate section according to Claim 1, characterized in that one of the carrier layer sections is wider than the other section by the amount of the overlap.

3. Substrate section according to Claim 1 , characterized in that both carrier layer sections are, by the amount of half the overlap, wider than half the width dimension of an undivided carrier layer.

4. Substrate section according to Claims 1 to 3, characterized in that the region of overlap is positioned centrally or eccentrically on the substrate section.