CA2372393A1 - Novel proteins with insulin-like activity useful in the treatment of diabetes - Google Patents

Novel proteins with insulin-like activity useful in the treatment of diabetes Download PDF

Info

Publication number
CA2372393A1
CA2372393A1 CA002372393A CA2372393A CA2372393A1 CA 2372393 A1 CA2372393 A1 CA 2372393A1 CA 002372393 A CA002372393 A CA 002372393A CA 2372393 A CA2372393 A CA 2372393A CA 2372393 A1 CA2372393 A1 CA 2372393A1
Authority
CA
Canada
Prior art keywords
protein
insulin
sequence
amino acid
residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002372393A
Other languages
English (en)
French (fr)
Inventor
Bassil I. Dahiyat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xencor Inc
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of CA2372393A1 publication Critical patent/CA2372393A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA002372393A 1999-05-19 2000-05-19 Novel proteins with insulin-like activity useful in the treatment of diabetes Abandoned CA2372393A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13493099P 1999-05-19 1999-05-19
US60/134,930 1999-05-19
PCT/US2000/013764 WO2000069901A2 (en) 1999-05-19 2000-05-19 Proteins with insulin-like activity useful in the treatment of diabetes

Publications (1)

Publication Number Publication Date
CA2372393A1 true CA2372393A1 (en) 2000-11-23

Family

ID=22465651

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002372393A Abandoned CA2372393A1 (en) 1999-05-19 2000-05-19 Novel proteins with insulin-like activity useful in the treatment of diabetes

Country Status (4)

Country Link
JP (1) JP2003518917A (ja)
AU (1) AU5144400A (ja)
CA (1) CA2372393A1 (ja)
WO (1) WO2000069901A2 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000040612A1 (en) 1999-01-06 2000-07-13 Genentech, Inc. Insulin-like growth factor (igf) i mutant variants
JP3971108B2 (ja) 1999-01-06 2007-09-05 ジェネンテック・インコーポレーテッド インシュリン様成長因子（ｉｇｆ）ｉ突然変異体
AU2001263215A1 (en) 2000-05-16 2001-11-26 Genentech Inc. Method for treating cartilage disorders
EP1644411A2 (en) * 2003-07-11 2006-04-12 Novo Nordisk A/S Stabilised insulin compositions
WO2008034881A1 (en) * 2006-09-22 2008-03-27 Novo Nordisk A/S Protease resistant insulin analogues
EP2254905B1 (en) 2008-03-14 2016-12-14 Novo Nordisk A/S Protease-stabilized insulin analogues
WO2009115469A1 (en) 2008-03-18 2009-09-24 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
JP2012511506A (ja) * 2008-12-09 2012-05-24 ノヴォ・ノルディスク・アー／エス 新規インスリンアナログ
CN103533952B (zh) * 2011-03-15 2017-02-15 诺沃—诺迪斯克有限公司 包含半胱氨酸置换的人胰岛素类似物和衍生物
US9896496B2 (en) 2013-10-07 2018-02-20 Novo Nordisk A/S Derivative of an insulin analogue
AU2017378102B2 (en) 2016-12-16 2022-10-13 Novo Nordisk A/S Insulin containing pharmaceutical compositions
US10919949B2 (en) * 2017-08-17 2021-02-16 Novo Nordisk A/S Acylated insulin analogues and uses thereof
CN112843082B (zh) * 2021-02-02 2022-07-05 四川大学 Dna四面体在制备治疗糖尿病的药物中的用途
CN112843081B (zh) * 2021-02-02 2022-07-05 四川大学 一种dna四面体-白藜芦醇复合物及其制备方法和用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268453A (en) * 1991-08-08 1993-12-07 Scios Inc. Tissue-selective insulin analogs

Also Published As

Publication number Publication date
WO2000069901A2 (en) 2000-11-23
JP2003518917A (ja) 2003-06-17
AU5144400A (en) 2000-12-05
WO2000069901A3 (en) 2002-09-12

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead