CA2372187A1 - Ras oncogen p21 peptide vaccines - Google Patents
Ras oncogen p21 peptide vaccines Download PDFInfo
- Publication number
- CA2372187A1 CA2372187A1 CA002372187A CA2372187A CA2372187A1 CA 2372187 A1 CA2372187 A1 CA 2372187A1 CA 002372187 A CA002372187 A CA 002372187A CA 2372187 A CA2372187 A CA 2372187A CA 2372187 A1 CA2372187 A1 CA 2372187A1
- Authority
- CA
- Canada
- Prior art keywords
- peptides
- peptide
- ras
- peptide mixture
- patients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 229940023041 peptide vaccine Drugs 0.000 title description 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 115
- 102000016914 ras Proteins Human genes 0.000 claims abstract description 80
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 47
- 239000000203 mixture Substances 0.000 claims abstract description 33
- 238000009566 cancer vaccine Methods 0.000 claims abstract description 4
- 229940022399 cancer vaccine Drugs 0.000 claims abstract description 4
- 230000007969 cellular immunity Effects 0.000 claims abstract description 4
- 238000011394 anticancer treatment Methods 0.000 claims abstract description 3
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 45
- 108010014186 ras Proteins Proteins 0.000 claims description 41
- 206010028980 Neoplasm Diseases 0.000 claims description 39
- 150000001413 amino acids Chemical class 0.000 claims description 22
- 201000011510 cancer Diseases 0.000 claims description 14
- 102000043276 Oncogene Human genes 0.000 claims description 11
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- 238000001727 in vivo Methods 0.000 claims description 2
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- 102200006532 rs112445441 Human genes 0.000 abstract 1
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- 239000000427 antigen Substances 0.000 description 16
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- 102000036639 antigens Human genes 0.000 description 16
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 12
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 12
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- 238000002347 injection Methods 0.000 description 11
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- 108090000623 proteins and genes Proteins 0.000 description 10
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 8
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- 230000004044 response Effects 0.000 description 8
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- 108700020978 Proto-Oncogene Proteins 0.000 description 4
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- 108010002350 Interleukin-2 Proteins 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
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- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 229940021747 therapeutic vaccine Drugs 0.000 description 2
- 101150080340 tlcD gene Proteins 0.000 description 2
- 230000005951 type IV hypersensitivity Effects 0.000 description 2
- 230000003442 weekly effect Effects 0.000 description 2
- VVQIIIAZJXTLRE-QMMMGPOBSA-N (2s)-2-amino-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid Chemical compound CC(C)(C)OC(=O)NCCCC[C@H](N)C(O)=O VVQIIIAZJXTLRE-QMMMGPOBSA-N 0.000 description 1
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- 206010027476 Metastases Diseases 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 230000006044 T cell activation Effects 0.000 description 1
- 230000006052 T cell proliferation Effects 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 239000012317 TBTU Substances 0.000 description 1
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 1
- CLZISMQKJZCZDN-UHFFFAOYSA-N [benzotriazol-1-yloxy(dimethylamino)methylidene]-dimethylazanium Chemical compound C1=CC=C2N(OC(N(C)C)=[N+](C)C)N=NC2=C1 CLZISMQKJZCZDN-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000002072 anti-mutant effect Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
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- 238000013459 approach Methods 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 210000003719 b-lymphocyte Anatomy 0.000 description 1
- 230000037429 base substitution Effects 0.000 description 1
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- 230000005907 cancer growth Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000022534 cell killing Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 238000010367 cloning Methods 0.000 description 1
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- 239000000824 cytostatic agent Substances 0.000 description 1
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- RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
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- 230000006870 function Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000007614 genetic variation Effects 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 102000055277 human IL2 Human genes 0.000 description 1
- 210000003917 human chromosome Anatomy 0.000 description 1
- 230000005934 immune activation Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 210000001165 lymph node Anatomy 0.000 description 1
- 210000003810 lymphokine-activated killer cell Anatomy 0.000 description 1
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- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000009401 metastasis Effects 0.000 description 1
- 230000000869 mutational effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 108700042226 ras Genes Proteins 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
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- 101150009136 tlcA gene Proteins 0.000 description 1
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- 230000005945 translocation Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001164—GTPases, e.g. Ras or Rho
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO19992102 | 1999-04-30 | ||
| NO19992102A NO309798B1 (no) | 1999-04-30 | 1999-04-30 | Peptidblanding, samt farmasoytisk sammensetning og kreftvaksine som innbefatter peptidblandingen |
| PCT/NO2000/000142 WO2000066153A1 (en) | 1999-04-30 | 2000-04-28 | RAS ONCOGEN p21 PEPTIDE VACCINES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2372187A1 true CA2372187A1 (en) | 2000-11-09 |
Family
ID=19903274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002372187A Abandoned CA2372187A1 (en) | 1999-04-30 | 2000-04-28 | Ras oncogen p21 peptide vaccines |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1173199A1 (no) |
| JP (1) | JP2002543149A (no) |
| AR (1) | AR023806A1 (no) |
| AU (1) | AU4438900A (no) |
| CA (1) | CA2372187A1 (no) |
| NO (1) | NO309798B1 (no) |
| WO (1) | WO2000066153A1 (no) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11771749B2 (en) | 2017-02-03 | 2023-10-03 | The Medical College Of Wisconsin, Inc. | KRAS peptide vaccine compositions and method of use |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2836684B1 (fr) * | 2002-03-04 | 2004-12-17 | Inst Nat Sante Rech Med | Peptides ras mutes et leur utilisation en immunotherapie |
| AU2003301021C1 (en) | 2002-12-16 | 2010-02-18 | Globelmmune, Inc. | Yeast-based vaccines as immunotherapy |
| US8343502B2 (en) | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
| TW200806789A (en) | 2006-03-27 | 2008-02-01 | Globeimmune Inc | RAS mutation and compositions and methods related thereto |
| GB0821616D0 (en) | 2008-11-26 | 2008-12-31 | Lytix Biopharma As | Compounds |
| CN104548089B (zh) * | 2009-09-03 | 2017-09-26 | 辉瑞疫苗有限责任公司 | Pcsk9疫苗 |
| CA2797868C (en) | 2010-05-14 | 2023-06-20 | The General Hospital Corporation | Compositions and methods of identifying tumor specific neoantigens |
| CN102060929A (zh) * | 2010-06-07 | 2011-05-18 | 夏书奇 | T细胞免疫平衡肽 |
| US10801070B2 (en) | 2013-11-25 | 2020-10-13 | The Broad Institute, Inc. | Compositions and methods for diagnosing, evaluating and treating cancer |
| US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| EP3369432A1 (en) | 2013-12-09 | 2018-09-05 | Targovax Asa | A peptide mixture |
| CN106456724A (zh) | 2013-12-20 | 2017-02-22 | 博德研究所 | 使用新抗原疫苗的联合疗法 |
| US9757439B2 (en) * | 2014-05-06 | 2017-09-12 | Targovax Asa | Peptide vaccine comprising mutant RAS peptide and chemotherapeutic agent |
| EP3234130B1 (en) | 2014-12-19 | 2020-11-25 | The Broad Institute, Inc. | Methods for profiling the t-cell- receptor repertoire |
| EP3234193B1 (en) | 2014-12-19 | 2020-07-15 | Massachusetts Institute of Technology | Molecular biomarkers for cancer immunotherapy |
| TWI806815B (zh) | 2015-05-20 | 2023-07-01 | 美商博德研究所有限公司 | 共有之ｇａｔａ３相關之腫瘤特異性新抗原 |
| RU2018101225A (ru) * | 2015-06-16 | 2019-07-16 | Тарговакс Аса | Мутированные фрагменты белка ras |
| US11549149B2 (en) | 2017-01-24 | 2023-01-10 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| BR112019015797A2 (pt) | 2017-02-01 | 2020-03-17 | Modernatx, Inc. | Composições de mrna terapêuticas imunomoduladoras que codificam peptídeos de mutação de oncogene de ativação |
| TW201930340A (zh) | 2017-12-18 | 2019-08-01 | 美商尼恩醫療公司 | 新抗原及其用途 |
| CN114573688A (zh) * | 2018-10-19 | 2022-06-03 | 杭州纽安津生物科技有限公司 | 通用性多肽疫苗及其在制备治疗/预防胰腺癌药物中的应用 |
| JPWO2020145222A1 (no) * | 2019-01-07 | 2020-07-16 | ||
| IL266728B (en) * | 2019-05-19 | 2020-11-30 | Yeda Res & Dev | Identification of recurrent mutant neopeptides |
| IL295624A (en) * | 2020-02-19 | 2022-10-01 | Aelin Therapeutics | Protein targeting molecules |
| CN115427057A (zh) * | 2020-02-19 | 2022-12-02 | 艾琳治疗公司 | 靶向突变ras蛋白的分子 |
| WO2022219152A1 (en) * | 2021-04-16 | 2022-10-20 | Oblique Therapeutics Ab | Kras antibodies |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957859A (en) * | 1988-02-16 | 1990-09-18 | Hoffmann-La Roche Inc. | Antibodies for transforming ras protein |
| GB9103974D0 (en) * | 1991-02-26 | 1991-04-10 | Norsk Hydro As | Therapeutically useful peptides or peptide fragments |
| ATE220718T1 (de) * | 1996-04-19 | 2002-08-15 | Us Gov Sec Health | Mutierte ras peptide zur zeugung von cd8+ zytitoxischen t lymphoizyten |
| GB9620350D0 (en) * | 1996-09-30 | 1996-11-13 | Maudsley David J | Cancer vaccine |
| GB2328689A (en) * | 1997-08-27 | 1999-03-03 | Norsk Hydro As | Peptides based on the p21 ras proto-oncogene protein for the treatment of cancer |
-
1999
- 1999-04-30 NO NO19992102A patent/NO309798B1/no not_active IP Right Cessation
-
2000
- 2000-04-28 AR ARP000102059A patent/AR023806A1/es unknown
- 2000-04-28 WO PCT/NO2000/000142 patent/WO2000066153A1/en not_active Application Discontinuation
- 2000-04-28 AU AU44389/00A patent/AU4438900A/en not_active Abandoned
- 2000-04-28 JP JP2000615037A patent/JP2002543149A/ja active Pending
- 2000-04-28 CA CA002372187A patent/CA2372187A1/en not_active Abandoned
- 2000-04-28 EP EP00925746A patent/EP1173199A1/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11771749B2 (en) | 2017-02-03 | 2023-10-03 | The Medical College Of Wisconsin, Inc. | KRAS peptide vaccine compositions and method of use |
Also Published As
| Publication number | Publication date |
|---|---|
| AU4438900A (en) | 2000-11-17 |
| AR023806A1 (es) | 2002-09-04 |
| WO2000066153A1 (en) | 2000-11-09 |
| JP2002543149A (ja) | 2002-12-17 |
| EP1173199A1 (en) | 2002-01-23 |
| NO992102D0 (no) | 1999-04-30 |
| NO309798B1 (no) | 2001-04-02 |
| NO992102L (no) | 2000-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |