CA2370284A1 - Peptide perturbateur de membrane oligomerise par covalence - Google Patents

Peptide perturbateur de membrane oligomerise par covalence Download PDF

Info

Publication number
CA2370284A1
CA2370284A1 CA002370284A CA2370284A CA2370284A1 CA 2370284 A1 CA2370284 A1 CA 2370284A1 CA 002370284 A CA002370284 A CA 002370284A CA 2370284 A CA2370284 A CA 2370284A CA 2370284 A1 CA2370284 A1 CA 2370284A1
Authority
CA
Canada
Prior art keywords
peptide
modified
membrane disruptive
delivery complex
complex according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002370284A
Other languages
English (en)
Inventor
Ross Owen Phillips
John Hamilton Welsh
Rhonda Darphi Husain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovata Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9909567.1A external-priority patent/GB9909567D0/en
Priority claimed from GBGB9916912.0A external-priority patent/GB9916912D0/en
Priority claimed from GBGB9928303.8A external-priority patent/GB9928303D0/en
Application filed by Individual filed Critical Individual
Publication of CA2370284A1 publication Critical patent/CA2370284A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43572—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from bees
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Insects & Arthropods (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

la présente invention concerne un peptide perturbateur de membrane modifié. Cette invention concerne aussi un complexe d'administration comprenant ce peptide perturbateur de membrane modifié et l'utilisation de ce complexe. Ce peptide perturbateur de membrane modifié est modifié de façon à former un multimère lié par covalence.
CA002370284A 1999-04-26 2000-04-25 Peptide perturbateur de membrane oligomerise par covalence Abandoned CA2370284A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB9909567.1 1999-04-26
GBGB9909567.1A GB9909567D0 (en) 1999-04-26 1999-04-26 A modified membrane disruptive peptide
US13237699P 1999-05-04 1999-05-04
US60/132,376 1999-05-04
GB9916912.0 1999-07-19
GBGB9916912.0A GB9916912D0 (en) 1999-07-19 1999-07-19 A modified membrane disruptive peptide
GBGB9928303.8A GB9928303D0 (en) 1999-11-30 1999-11-30 A modified membrane disruptive peptide
GB9928303.8 1999-11-30
PCT/GB2000/001588 WO2000064929A1 (fr) 1999-04-26 2000-04-25 Peptide perturbateur de membrane oligomerise par covalence

Publications (1)

Publication Number Publication Date
CA2370284A1 true CA2370284A1 (fr) 2000-11-02

Family

ID=27451899

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002370284A Abandoned CA2370284A1 (fr) 1999-04-26 2000-04-25 Peptide perturbateur de membrane oligomerise par covalence

Country Status (9)

Country Link
EP (1) EP1173474A1 (fr)
JP (1) JP2002544126A (fr)
KR (1) KR20020007382A (fr)
CN (1) CN1349543A (fr)
AU (1) AU4584800A (fr)
CA (1) CA2370284A1 (fr)
HK (1) HK1044003A1 (fr)
IL (1) IL145885A0 (fr)
WO (1) WO2000064929A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7446099B2 (en) 2004-02-27 2008-11-04 Nitto Denko Corporation Compositions and methods for biodegradable polymer-peptide mediated transfection
CN106589102A (zh) * 2016-11-30 2017-04-26 青岛大学 Orexin‑A聚乙二醇化修饰物制备及用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1010692C2 (nl) * 1998-12-01 2000-06-06 Stichting Tech Wetenschapp Antivirale peptiden.

Also Published As

Publication number Publication date
JP2002544126A (ja) 2002-12-24
HK1044003A1 (zh) 2002-10-04
IL145885A0 (en) 2002-07-25
EP1173474A1 (fr) 2002-01-23
WO2000064929A1 (fr) 2000-11-02
AU4584800A (en) 2000-11-10
KR20020007382A (ko) 2002-01-26
CN1349543A (zh) 2002-05-15

Similar Documents

Publication Publication Date Title
Hofer et al. Members of the low density lipoprotein receptor family mediate cell entry of a minor-group common cold virus.
CN108064173B (zh) 胰岛素受体部分激动剂
Myszka et al. Design and characterization of an intramolecular antiparallel coiled coil peptide
CN107075574A (zh) 铁调素和微型铁调素类似物及其用途
KR20100085527A (ko) 신규한 세포막 투과 도메인 및 이를 포함하는 세포내 전달 시스템
JP2003514564A (ja) 核局在化シグナルまたはタンパク質導入領域の多量体を含むポリペプチド、および分子を細胞内へ移入するためのその使用法
US11952432B2 (en) Cell-permeable stapled peptide modules for cellular delivery
WO1994022466A1 (fr) Procedes d'utilisation de proteines de liaison de facteurs de croissance semblables a l'insuline
EP1756160A2 (fr) Peptides oligomeres et leur utilisation pour traiter des infections a vih
WO2016019872A1 (fr) Vecteur d'acide nucleique, procede de preparation et utilisation de celui-ci
KR20150032265A (ko) 세포 침투성 펩티드 및 세포 침투성 펩티드의 식별 방법
BRPI0203394B1 (pt) proteína de fusão, ácido nucleico, e, processo para a preparação de uma proteína de fusão tendo atividade intensificada in vivo da epo humana
IL290414B1 (en) ATF5 peptide variants and uses thereof
Cary et al. Conformation and Domain Structure of the Non‐histone Chromosomal Proteins, HMG 1 and 2: Isolation of Two Folded Fragments from HMG 1 and 2
KR20020010928A (ko) 인테그린 αｖβ６의 억제제로서의 사이클릭 펩타이드유도체
US20160038567A1 (en) Eif4e binding peptides
Yang et al. The structure and configuration changes of multifunctional peptide vectors enhance gene delivery efficiency
CA2370284A1 (fr) Peptide perturbateur de membrane oligomerise par covalence
Khemtémourian et al. Synthesis and secondary structure in membranes of the Bcl‐2 anti‐apoptotic domain BH4
AU2021304762A1 (en) Novel polypeptide and therapeutic use thereof
CN114940711B (zh) 载脂蛋白a-i模拟肽及其应用
Freulon et al. Spacer length dependence on the efficiency of dimeric anionic peptides in gene transfer by glycosylated polylysine/plasmid complexes
AU6221198A (en) Compositions and methods for highly efficient transfection
KR101444197B1 (ko) 세포막 투과용 단백질 및 그 용도
CN109134659B (zh) 一种核酸载体及其用途

Legal Events

Date Code Title Description
FZDE Discontinued