CA2367648A1 - Recombinant adeno-associated virus transfer of genes affecting demyelination - Google Patents

Recombinant adeno-associated virus transfer of genes affecting demyelination Download PDF

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Publication number
CA2367648A1
CA2367648A1 CA002367648A CA2367648A CA2367648A1 CA 2367648 A1 CA2367648 A1 CA 2367648A1 CA 002367648 A CA002367648 A CA 002367648A CA 2367648 A CA2367648 A CA 2367648A CA 2367648 A1 CA2367648 A1 CA 2367648A1
Authority
CA
Canada
Prior art keywords
catalase
raav
optic nerve
composition
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002367648A
Other languages
English (en)
French (fr)
Inventor
Xiaoping Qi
William W. Hauswirth
John Guy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2367648A1 publication Critical patent/CA2367648A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA002367648A 1999-03-15 2000-03-15 Recombinant adeno-associated virus transfer of genes affecting demyelination Abandoned CA2367648A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12439899P 1999-03-15 1999-03-15
US60/124,398 1999-03-15
PCT/US2000/006839 WO2000054595A1 (en) 1999-03-15 2000-03-15 Recombinant adeno-associated virus transfer of genes affecting demyelination

Publications (1)

Publication Number Publication Date
CA2367648A1 true CA2367648A1 (en) 2000-09-21

Family

ID=22414629

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002367648A Abandoned CA2367648A1 (en) 1999-03-15 2000-03-15 Recombinant adeno-associated virus transfer of genes affecting demyelination

Country Status (4)

Country Link
EP (1) EP1162887A4 (de)
AU (1) AU3629200A (de)
CA (1) CA2367648A1 (de)
WO (1) WO2000054595A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008065429A1 (en) * 2006-11-30 2008-06-05 Ucl Business Plc Method for delivering gene therapy vectors to the optic nerve head
WO2014124142A2 (en) * 2013-02-07 2014-08-14 The Cleveland Clinic Foundation Methods of treating spinal cord injury
JP6317440B2 (ja) 2013-10-29 2018-04-25 プレジデント アンド フェローズ オブ ハーバード カレッジ 酸化ストレスを阻害するための方法および組成物
RU2649814C1 (ru) * 2017-02-14 2018-04-04 Общество с ограниченной ответственностью "Медсервис" Средство для лечения состояний человеческого организма, связанных с уменьшением уровня экспрессии гена сат и/или уменьшением активности белка каталазы на основе генно-терапевтических субстанций с геном сат, способ получения и использования

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE386131T1 (de) * 1994-04-13 2008-03-15 Univ Rockefeller Aav-vermittelte überbringung von dna in zellen des nervensystems
US5658785A (en) * 1994-06-06 1997-08-19 Children's Hospital, Inc. Adeno-associated virus materials and methods

Also Published As

Publication number Publication date
EP1162887A1 (de) 2001-12-19
AU3629200A (en) 2000-10-04
EP1162887A4 (de) 2003-06-25
WO2000054595A1 (en) 2000-09-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued