EP1162887A4 - Rekombinanter adeno-assoziierter virus transfer von die demyelination beeinflussenden genen - Google Patents

Rekombinanter adeno-assoziierter virus transfer von die demyelination beeinflussenden genen

Info

Publication number
EP1162887A4
EP1162887A4 EP00914979A EP00914979A EP1162887A4 EP 1162887 A4 EP1162887 A4 EP 1162887A4 EP 00914979 A EP00914979 A EP 00914979A EP 00914979 A EP00914979 A EP 00914979A EP 1162887 A4 EP1162887 A4 EP 1162887A4
Authority
EP
European Patent Office
Prior art keywords
demyelination
associated virus
recombinant adeno
genes affecting
virus transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00914979A
Other languages
English (en)
French (fr)
Other versions
EP1162887A1 (de
Inventor
John Guy
Xiaoping Qi
William W Hauswirth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP1162887A1 publication Critical patent/EP1162887A1/de
Publication of EP1162887A4 publication Critical patent/EP1162887A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
EP00914979A 1999-03-15 2000-03-15 Rekombinanter adeno-assoziierter virus transfer von die demyelination beeinflussenden genen Withdrawn EP1162887A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12439899P 1999-03-15 1999-03-15
US124398P 1999-03-15
PCT/US2000/006839 WO2000054595A1 (en) 1999-03-15 2000-03-15 Recombinant adeno-associated virus transfer of genes affecting demyelination

Publications (2)

Publication Number Publication Date
EP1162887A1 EP1162887A1 (de) 2001-12-19
EP1162887A4 true EP1162887A4 (de) 2003-06-25

Family

ID=22414629

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00914979A Withdrawn EP1162887A4 (de) 1999-03-15 2000-03-15 Rekombinanter adeno-assoziierter virus transfer von die demyelination beeinflussenden genen

Country Status (4)

Country Link
EP (1) EP1162887A4 (de)
AU (1) AU3629200A (de)
CA (1) CA2367648A1 (de)
WO (1) WO2000054595A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008065429A1 (en) * 2006-11-30 2008-06-05 Ucl Business Plc Method for delivering gene therapy vectors to the optic nerve head
US11439690B2 (en) 2013-02-07 2022-09-13 The Cleveland Clinic Foundation Methods of treating spinal cord injury
WO2015066190A1 (en) 2013-10-29 2015-05-07 President And Fellows Of Harvard College Methods and compositions for inhibting oxidative stress
RU2649814C1 (ru) * 2017-02-14 2018-04-04 Общество с ограниченной ответственностью "Медсервис" Средство для лечения состояний человеческого организма, связанных с уменьшением уровня экспрессии гена сат и/или уменьшением активности белка каталазы на основе генно-терапевтических субстанций с геном сат, способ получения и использования

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028493A1 (en) * 1994-04-13 1995-10-26 The Rockefeller University Aav-mediated delivery of dna to cells of the nervous system
WO1995034670A2 (en) * 1994-06-06 1995-12-21 Children's Hospital, Inc. Recombinant aav genome encoding immunodeficiency virus protein

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028493A1 (en) * 1994-04-13 1995-10-26 The Rockefeller University Aav-mediated delivery of dna to cells of the nervous system
WO1995034670A2 (en) * 1994-06-06 1995-12-21 Children's Hospital, Inc. Recombinant aav genome encoding immunodeficiency virus protein

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
GUY J ET AL: "rAAV mediated gene transfer of catalase suppresses optic neuritis in transgenic ECSOD mice sensitized for experimental allergic encephalomyelitis (EAE).", IOVS, vol. 40, no. 4, 15 March 1999 (1999-03-15), Annual Meeting of the Association for Research in Vision and Ophthalmology;Fort Lauderdale, Florida, USA; May 9-14, 1999, pages S446, XP009001280 *
GUY J ET AL: "Viral mediated gene transfer of MnSOD suppresses, while Cu/Zn SOD exacerbates experimental optic neuritis.", IOVS, vol. 41, no. 4, 15 March 2000 (2000-03-15), Annual Meeting of the Association for Research in Vision and Ophthalmology.;Fort Lauderdale, Florida, USA; April 30-May 05, 2000, pages S129, XP001119816 *
QI XIAOPING ET AL: "Increase of manganese superoxide dismutase, but not of Cu/Zn-SOD, in experimental optic neuritis.", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 38, no. 6, 1997, pages 1203 - 1212, XP009001342, ISSN: 0146-0404 *
ROSEN D R ET AL: "Mutations in copper-zinc superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 362, no. 6415, 1993, pages 59 - 62, XP002204594, ISSN: 0028-0836 *
ROWLAND L P: "Amyotrophic lateral sclerosis: human challenge for neuroscience.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. UNITED STATES 28 FEB 1995, vol. 92, no. 5, 28 February 1995 (1995-02-28), pages 1251 - 1253, XP002237399, ISSN: 0027-8424 *
See also references of WO0054595A1 *
VAN DER VEEN ROEL C ET AL: "Contrasting roles for nitric oxide and peroxynitrite in the peroxidation of myelin lipids.", JOURNAL OF NEUROIMMUNOLOGY, vol. 95, no. 1-2, 1 March 1999 (1999-03-01), pages 1 - 7, XP001120096, ISSN: 0165-5728 *

Also Published As

Publication number Publication date
AU3629200A (en) 2000-10-04
WO2000054595A1 (en) 2000-09-21
EP1162887A1 (de) 2001-12-19
CA2367648A1 (en) 2000-09-21

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