CA2367015A1 - Methods of treating tardive dyskinesia and other movement disorders - Google Patents
Methods of treating tardive dyskinesia and other movement disorders Download PDFInfo
- Publication number
- CA2367015A1 CA2367015A1 CA002367015A CA2367015A CA2367015A1 CA 2367015 A1 CA2367015 A1 CA 2367015A1 CA 002367015 A CA002367015 A CA 002367015A CA 2367015 A CA2367015 A CA 2367015A CA 2367015 A1 CA2367015 A1 CA 2367015A1
- Authority
- CA
- Canada
- Prior art keywords
- disorder
- gaba
- disorders
- nmda
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 208000016285 Movement disease Diseases 0.000 title claims abstract description 37
- 238000000034 method Methods 0.000 title claims description 110
- 206010043118 Tardive Dyskinesia Diseases 0.000 title description 18
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 119
- AFCGFAGUEYAMAO-UHFFFAOYSA-N acamprosate Chemical compound CC(=O)NCCCS(O)(=O)=O AFCGFAGUEYAMAO-UHFFFAOYSA-N 0.000 claims abstract description 100
- 208000024891 symptom Diseases 0.000 claims abstract description 95
- 229960004047 acamprosate Drugs 0.000 claims abstract description 92
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 84
- 238000011282 treatment Methods 0.000 claims abstract description 82
- 230000000694 effects Effects 0.000 claims abstract description 77
- 208000027520 Somatoform disease Diseases 0.000 claims abstract description 65
- 239000003483 4 aminobutyric acid A receptor stimulating agent Substances 0.000 claims abstract description 46
- 239000011777 magnesium Substances 0.000 claims abstract description 42
- 208000019901 Anxiety disease Diseases 0.000 claims abstract description 41
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical group [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims abstract description 41
- 229910052749 magnesium Inorganic materials 0.000 claims abstract description 41
- 239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims abstract description 37
- 208000028017 Psychotic disease Diseases 0.000 claims abstract description 21
- 150000001875 compounds Chemical class 0.000 claims abstract description 20
- 239000003825 glutamate receptor antagonist Substances 0.000 claims abstract description 16
- 208000019022 Mood disease Diseases 0.000 claims abstract description 12
- BUVGWDNTAWHSKI-UHFFFAOYSA-L acamprosate calcium Chemical compound [Ca+2].CC(=O)NCCCS([O-])(=O)=O.CC(=O)NCCCS([O-])(=O)=O BUVGWDNTAWHSKI-UHFFFAOYSA-L 0.000 claims abstract description 12
- 230000036963 noncompetitive effect Effects 0.000 claims abstract description 5
- 102000004310 Ion Channels Human genes 0.000 claims abstract description 4
- 108090000862 Ion Channels Proteins 0.000 claims abstract description 4
- 208000028173 post-traumatic stress disease Diseases 0.000 claims description 130
- 208000035475 disorder Diseases 0.000 claims description 112
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 86
- 239000003814 drug Substances 0.000 claims description 58
- 229940079593 drug Drugs 0.000 claims description 55
- 230000005062 synaptic transmission Effects 0.000 claims description 48
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 45
- 229930195712 glutamate Natural products 0.000 claims description 45
- 230000008448 thought Effects 0.000 claims description 41
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims description 40
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 40
- 230000005540 biological transmission Effects 0.000 claims description 38
- 230000006399 behavior Effects 0.000 claims description 31
- 208000000323 Tourette Syndrome Diseases 0.000 claims description 29
- 208000016620 Tourette disease Diseases 0.000 claims description 29
- 230000003252 repetitive effect Effects 0.000 claims description 26
- 231100000252 nontoxic Toxicity 0.000 claims description 24
- 230000003000 nontoxic effect Effects 0.000 claims description 24
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 claims description 23
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 claims description 23
- 230000008447 perception Effects 0.000 claims description 22
- 230000003285 pharmacodynamic effect Effects 0.000 claims description 22
- 208000022266 body dysmorphic disease Diseases 0.000 claims description 21
- 210000004556 brain Anatomy 0.000 claims description 19
- 230000007423 decrease Effects 0.000 claims description 19
- 229940002612 prodrug Drugs 0.000 claims description 19
- 239000000651 prodrug Substances 0.000 claims description 19
- 230000001225 therapeutic effect Effects 0.000 claims description 19
- 238000011161 development Methods 0.000 claims description 15
- 201000009032 substance abuse Diseases 0.000 claims description 15
- 210000004369 blood Anatomy 0.000 claims description 14
- 239000008280 blood Substances 0.000 claims description 14
- 239000006187 pill Substances 0.000 claims description 14
- 229940122459 Glutamate antagonist Drugs 0.000 claims description 13
- 208000033039 Somatisation disease Diseases 0.000 claims description 13
- 208000016994 somatization disease Diseases 0.000 claims description 13
- 229940099433 NMDA receptor antagonist Drugs 0.000 claims description 12
- SNKZJIOFVMKAOJ-UHFFFAOYSA-N 3-Aminopropanesulfonate Chemical class NCCCS(O)(=O)=O SNKZJIOFVMKAOJ-UHFFFAOYSA-N 0.000 claims description 11
- 239000003477 4 aminobutyric acid receptor stimulating agent Substances 0.000 claims description 11
- 210000004227 basal ganglia Anatomy 0.000 claims description 11
- 150000002500 ions Chemical class 0.000 claims description 11
- 210000004185 liver Anatomy 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- 201000000980 schizophrenia Diseases 0.000 claims description 11
- 208000011117 substance-related disease Diseases 0.000 claims description 11
- 201000001916 Hypochondriasis Diseases 0.000 claims description 10
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 claims description 10
- 230000033001 locomotion Effects 0.000 claims description 10
- 229910001425 magnesium ion Inorganic materials 0.000 claims description 10
- 159000000003 magnesium salts Chemical class 0.000 claims description 10
- 208000014094 Dystonic disease Diseases 0.000 claims description 9
- 208000023105 Huntington disease Diseases 0.000 claims description 9
- 208000012839 conversion disease Diseases 0.000 claims description 9
- 210000003715 limbic system Anatomy 0.000 claims description 9
- 231100000736 substance abuse Toxicity 0.000 claims description 9
- 208000007848 Alcoholism Diseases 0.000 claims description 8
- 201000007930 alcohol dependence Diseases 0.000 claims description 8
- 201000002904 focal dystonia Diseases 0.000 claims description 7
- 208000020925 Bipolar disease Diseases 0.000 claims description 6
- 206010008748 Chorea Diseases 0.000 claims description 6
- 208000018737 Parkinson disease Diseases 0.000 claims description 6
- 208000027522 Sydenham chorea Diseases 0.000 claims description 6
- 239000013543 active substance Substances 0.000 claims description 6
- 230000003190 augmentative effect Effects 0.000 claims description 6
- 239000013522 chelant Chemical class 0.000 claims description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 6
- 231100000419 toxicity Toxicity 0.000 claims description 6
- 230000001988 toxicity Effects 0.000 claims description 6
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 5
- 150000002148 esters Chemical class 0.000 claims description 5
- 229910052744 lithium Inorganic materials 0.000 claims description 5
- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical group C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 claims description 5
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 5
- 229940121869 GABA A receptor agonist Drugs 0.000 claims description 4
- 206010026749 Mania Diseases 0.000 claims description 4
- 229940127523 NMDA Receptor Antagonists Drugs 0.000 claims description 4
- 230000007812 deficiency Effects 0.000 claims description 4
- 229960004640 memantine Drugs 0.000 claims description 4
- 208000022610 schizoaffective disease Diseases 0.000 claims description 4
- 239000006188 syrup Substances 0.000 claims description 4
- 235000020357 syrup Nutrition 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 230000002195 synergetic effect Effects 0.000 claims description 3
- 108091006146 Channels Proteins 0.000 claims description 2
- 229940124447 delivery agent Drugs 0.000 claims 2
- 239000000203 mixture Substances 0.000 abstract description 12
- 239000002981 blocking agent Substances 0.000 abstract 1
- 238000011221 initial treatment Methods 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 30
- 230000036407 pain Effects 0.000 description 28
- 230000004044 response Effects 0.000 description 27
- 208000014674 injury Diseases 0.000 description 22
- 230000008733 trauma Effects 0.000 description 21
- 239000003772 serotonin uptake inhibitor Substances 0.000 description 20
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 description 19
- 230000001965 increasing effect Effects 0.000 description 19
- 230000000472 traumatic effect Effects 0.000 description 16
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 15
- 230000036506 anxiety Effects 0.000 description 15
- 208000020016 psychiatric disease Diseases 0.000 description 15
- 230000000306 recurrent effect Effects 0.000 description 14
- 230000009471 action Effects 0.000 description 13
- 230000018109 developmental process Effects 0.000 description 13
- 230000035882 stress Effects 0.000 description 13
- 206010029897 Obsessive thoughts Diseases 0.000 description 12
- 206010010219 Compulsions Diseases 0.000 description 10
- 206010016754 Flashback Diseases 0.000 description 10
- 102000004300 GABA-A Receptors Human genes 0.000 description 10
- 108090000839 GABA-A Receptors Proteins 0.000 description 10
- 230000001684 chronic effect Effects 0.000 description 10
- 230000007246 mechanism Effects 0.000 description 10
- 230000001404 mediated effect Effects 0.000 description 10
- 210000000225 synapse Anatomy 0.000 description 10
- 208000011580 syndromic disease Diseases 0.000 description 10
- 206010049119 Emotional distress Diseases 0.000 description 9
- 230000008901 benefit Effects 0.000 description 9
- 230000007310 pathophysiology Effects 0.000 description 9
- 102000005962 receptors Human genes 0.000 description 9
- 108020003175 receptors Proteins 0.000 description 9
- 210000000278 spinal cord Anatomy 0.000 description 9
- 239000005557 antagonist Substances 0.000 description 8
- 239000003210 dopamine receptor blocking agent Substances 0.000 description 8
- 230000002996 emotional effect Effects 0.000 description 8
- 208000024714 major depressive disease Diseases 0.000 description 8
- 239000000935 antidepressant agent Substances 0.000 description 7
- 229940049706 benzodiazepine Drugs 0.000 description 7
- 206010005159 blepharospasm Diseases 0.000 description 7
- 230000000744 blepharospasm Effects 0.000 description 7
- 230000004064 dysfunction Effects 0.000 description 7
- 238000002483 medication Methods 0.000 description 7
- 230000003236 psychic effect Effects 0.000 description 7
- 208000012661 Dyskinesia Diseases 0.000 description 6
- 206010029412 Nightmare Diseases 0.000 description 6
- 210000004727 amygdala Anatomy 0.000 description 6
- 150000001557 benzodiazepines Chemical class 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 230000009429 distress Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 230000001537 neural effect Effects 0.000 description 6
- 239000002858 neurotransmitter agent Substances 0.000 description 6
- 239000002831 pharmacologic agent Substances 0.000 description 6
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 6
- 230000000638 stimulation Effects 0.000 description 6
- 208000037490 Medically Unexplained Symptoms Diseases 0.000 description 5
- 208000012902 Nervous system disease Diseases 0.000 description 5
- 208000000450 Pelvic Pain Diseases 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000008484 agonism Effects 0.000 description 5
- 230000008485 antagonism Effects 0.000 description 5
- 229940005513 antidepressants Drugs 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 230000027928 long-term synaptic potentiation Effects 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 239000003176 neuroleptic agent Substances 0.000 description 5
- 230000001242 postsynaptic effect Effects 0.000 description 5
- 238000012552 review Methods 0.000 description 5
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 5
- 241000282412 Homo Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 208000025966 Neurological disease Diseases 0.000 description 4
- 208000026345 acute stress disease Diseases 0.000 description 4
- 230000037007 arousal Effects 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 238000010494 dissociation reaction Methods 0.000 description 4
- 230000005593 dissociations Effects 0.000 description 4
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
- 230000002964 excitative effect Effects 0.000 description 4
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 4
- 230000004179 hypothalamic–pituitary–adrenal axis Effects 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 210000001577 neostriatum Anatomy 0.000 description 4
- 230000000701 neuroleptic effect Effects 0.000 description 4
- 208000019906 panic disease Diseases 0.000 description 4
- 239000008177 pharmaceutical agent Substances 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 230000000862 serotonergic effect Effects 0.000 description 4
- 230000000392 somatic effect Effects 0.000 description 4
- 230000024188 startle response Effects 0.000 description 4
- 208000016686 tic disease Diseases 0.000 description 4
- DBGIVFWFUFKIQN-VIFPVBQESA-N (+)-Fenfluramine Chemical compound CCN[C@@H](C)CC1=CC=CC(C(F)(F)F)=C1 DBGIVFWFUFKIQN-VIFPVBQESA-N 0.000 description 3
- 206010016275 Fear Diseases 0.000 description 3
- 102000018899 Glutamate Receptors Human genes 0.000 description 3
- 108010027915 Glutamate Receptors Proteins 0.000 description 3
- 208000015592 Involuntary movements Diseases 0.000 description 3
- 208000001294 Nociceptive Pain Diseases 0.000 description 3
- 102000003946 Prolactin Human genes 0.000 description 3
- 108010057464 Prolactin Proteins 0.000 description 3
- 206010058895 Psychogenic seizure Diseases 0.000 description 3
- 208000027465 Psychotic Affective disease Diseases 0.000 description 3
- 206010042458 Suicidal ideation Diseases 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 3
- 230000005856 abnormality Effects 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 239000001961 anticonvulsive agent Substances 0.000 description 3
- 239000000164 antipsychotic agent Substances 0.000 description 3
- 239000002249 anxiolytic agent Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000003169 central nervous system Anatomy 0.000 description 3
- 230000001149 cognitive effect Effects 0.000 description 3
- 229960004597 dexfenfluramine Drugs 0.000 description 3
- 230000008482 dysregulation Effects 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 229960004038 fluvoxamine Drugs 0.000 description 3
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 description 3
- 208000013403 hyperactivity Diseases 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 230000002197 limbic effect Effects 0.000 description 3
- 230000015654 memory Effects 0.000 description 3
- 230000003340 mental effect Effects 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000036651 mood Effects 0.000 description 3
- 230000017311 musculoskeletal movement, spinal reflex action Effects 0.000 description 3
- 230000000926 neurological effect Effects 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000002085 persistent effect Effects 0.000 description 3
- 230000003518 presynaptic effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 229940097325 prolactin Drugs 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 229940076279 serotonin Drugs 0.000 description 3
- 230000001568 sexual effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 210000001103 thalamus Anatomy 0.000 description 3
- 230000009898 traumatic memory Effects 0.000 description 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 2
- 208000008811 Agoraphobia Diseases 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 2
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 2
- 206010011953 Decreased activity Diseases 0.000 description 2
- 208000020401 Depressive disease Diseases 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 206010063006 Facial spasm Diseases 0.000 description 2
- 102000005915 GABA Receptors Human genes 0.000 description 2
- 108010005551 GABA Receptors Proteins 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 208000004095 Hemifacial Spasm Diseases 0.000 description 2
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 description 2
- 208000013716 Motor tics Diseases 0.000 description 2
- 208000007443 Neurasthenia Diseases 0.000 description 2
- 108010093625 Opioid Peptides Proteins 0.000 description 2
- 102000001490 Opioid Peptides Human genes 0.000 description 2
- 208000021155 Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infection Diseases 0.000 description 2
- 206010033664 Panic attack Diseases 0.000 description 2
- LHNKBXRFNPMIBR-UHFFFAOYSA-N Picrotoxin Natural products CC(C)(O)C1(O)C2OC(=O)C1C3(O)C4OC4C5C(=O)OC2C35C LHNKBXRFNPMIBR-UHFFFAOYSA-N 0.000 description 2
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 208000008234 Tics Diseases 0.000 description 2
- 208000031674 Traumatic Acute Stress disease Diseases 0.000 description 2
- 229940123445 Tricyclic antidepressant Drugs 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 2
- 239000000384 adrenergic alpha-2 receptor agonist Substances 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 239000003194 amino acid receptor blocking agent Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 229940125713 antianxiety drug Drugs 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 230000003416 augmentation Effects 0.000 description 2
- 239000000749 benzodiazepine receptor blocking agent Substances 0.000 description 2
- 230000003925 brain function Effects 0.000 description 2
- QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 description 2
- 229960002495 buspirone Drugs 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- DGBIGWXXNGSACT-UHFFFAOYSA-N clonazepam Chemical compound C12=CC([N+](=O)[O-])=CC=C2NC(=O)CN=C1C1=CC=CC=C1Cl DGBIGWXXNGSACT-UHFFFAOYSA-N 0.000 description 2
- 229960003120 clonazepam Drugs 0.000 description 2
- 229960002896 clonidine Drugs 0.000 description 2
- 230000007278 cognition impairment Effects 0.000 description 2
- 208000010877 cognitive disease Diseases 0.000 description 2
- 231100000867 compulsive behavior Toxicity 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 description 2
- 229960001140 cyproheptadine Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 229960003638 dopamine Drugs 0.000 description 2
- 208000024732 dysthymic disease Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- OFBIFZUFASYYRE-UHFFFAOYSA-N flumazenil Chemical compound C1N(C)C(=O)C2=CC(F)=CC=C2N2C=NC(C(=O)OCC)=C21 OFBIFZUFASYYRE-UHFFFAOYSA-N 0.000 description 2
- 229960004381 flumazenil Drugs 0.000 description 2
- 230000003371 gabaergic effect Effects 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 229960003878 haloperidol Drugs 0.000 description 2
- 229960000890 hydrocortisone Drugs 0.000 description 2
- 230000000266 injurious effect Effects 0.000 description 2
- 230000003834 intracellular effect Effects 0.000 description 2
- 238000009140 magnesium supplementation Methods 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000002899 monoamine oxidase inhibitor Substances 0.000 description 2
- 239000004050 mood stabilizer Substances 0.000 description 2
- 229940127237 mood stabilizer Drugs 0.000 description 2
- 230000002969 morbid Effects 0.000 description 2
- 230000001423 neocortical effect Effects 0.000 description 2
- 208000004296 neuralgia Diseases 0.000 description 2
- 238000002610 neuroimaging Methods 0.000 description 2
- 210000002569 neuron Anatomy 0.000 description 2
- 208000021722 neuropathic pain Diseases 0.000 description 2
- 229960002748 norepinephrine Drugs 0.000 description 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 2
- 229940127240 opiate Drugs 0.000 description 2
- 230000010355 oscillation Effects 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 230000037361 pathway Effects 0.000 description 2
- 210000000578 peripheral nerve Anatomy 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000008288 physiological mechanism Effects 0.000 description 2
- VJKUPQSHOVKBCO-AHMKVGDJSA-N picrotoxin Chemical compound O=C([C@@]12O[C@@H]1C[C@]1(O)[C@@]32C)O[C@@H]3[C@H]2[C@@H](C(=C)C)[C@@H]1C(=O)O2.O=C([C@@]12O[C@@H]1C[C@]1(O)[C@@]32C)O[C@@H]3[C@H]2[C@@H](C(C)(O)C)[C@@H]1C(=O)O2 VJKUPQSHOVKBCO-AHMKVGDJSA-N 0.000 description 2
- 210000004044 posterior horn cell Anatomy 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000004884 risky behavior Effects 0.000 description 2
- 230000022676 rumination Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 238000011272 standard treatment Methods 0.000 description 2
- QMGVPVSNSZLJIA-FVWCLLPLSA-N strychnine Chemical compound O([C@H]1CC(N([C@H]2[C@H]1[C@H]1C3)C=4C5=CC=CC=4)=O)CC=C1CN1[C@@H]3[C@]25CC1 QMGVPVSNSZLJIA-FVWCLLPLSA-N 0.000 description 2
- 230000009469 supplementation Effects 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- 239000003029 tricyclic antidepressant agent Substances 0.000 description 2
- 208000037975 work-related injury Diseases 0.000 description 2
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 1
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- ZYHIUZAQPKGNSO-UHFFFAOYSA-N 1-acetamidopropane-1-sulfonic acid Chemical group CCC(S(O)(=O)=O)NC(C)=O ZYHIUZAQPKGNSO-UHFFFAOYSA-N 0.000 description 1
- ZIRURAJAJIQZFG-UHFFFAOYSA-N 1-aminopropane-1-sulfonic acid Chemical group CCC(N)S(O)(=O)=O ZIRURAJAJIQZFG-UHFFFAOYSA-N 0.000 description 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 description 1
- 239000003140 4 aminobutyric acid A receptor blocking agent Substances 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 206010002859 Anxiety disorder due to a general medical condition Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 102000007527 Autoreceptors Human genes 0.000 description 1
- 108010071131 Autoreceptors Proteins 0.000 description 1
- 101800005049 Beta-endorphin Proteins 0.000 description 1
- 208000021465 Brief psychotic disease Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 108090000312 Calcium Channels Proteins 0.000 description 1
- 102000003922 Calcium Channels Human genes 0.000 description 1
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010010778 Constricted affect Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 101800000414 Corticotropin Proteins 0.000 description 1
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
- DYDCUQKUCUHJBH-UWTATZPHSA-N D-Cycloserine Chemical compound N[C@@H]1CONC1=O DYDCUQKUCUHJBH-UWTATZPHSA-N 0.000 description 1
- DYDCUQKUCUHJBH-UHFFFAOYSA-N D-Cycloserine Natural products NC1CONC1=O DYDCUQKUCUHJBH-UHFFFAOYSA-N 0.000 description 1
- 206010011971 Decreased interest Diseases 0.000 description 1
- 208000024254 Delusional disease Diseases 0.000 description 1
- 206010013470 Dissociative states Diseases 0.000 description 1
- 108700003861 Dominant Genes Proteins 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 206010049096 Dysmorphophobia Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 229940121909 GABA receptor agonist Drugs 0.000 description 1
- 230000009508 GABAergic inhibition Effects 0.000 description 1
- 208000011688 Generalised anxiety disease Diseases 0.000 description 1
- 102000008214 Glutamate decarboxylase Human genes 0.000 description 1
- 108091022930 Glutamate decarboxylase Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010019196 Head injury Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010020852 Hypertonia Diseases 0.000 description 1
- 206010048533 Hypervigilance Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000004404 Intractable Pain Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 206010027387 Merycism Diseases 0.000 description 1
- 206010027944 Mood disorder due to a general medical condition Diseases 0.000 description 1
- 206010061296 Motor dysfunction Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 description 1
- 208000025174 PANDAS Diseases 0.000 description 1
- 206010052794 Panic disorder with agoraphobia Diseases 0.000 description 1
- 206010033668 Panic disorder without agoraphobia Diseases 0.000 description 1
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 1
- 206010034912 Phobia Diseases 0.000 description 1
- 206010037180 Psychiatric symptoms Diseases 0.000 description 1
- 206010037211 Psychomotor hyperactivity Diseases 0.000 description 1
- 206010061921 Psychotic disorder due to a general medical condition Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 208000020186 Schizophreniform disease Diseases 0.000 description 1
- 208000033712 Self injurious behaviour Diseases 0.000 description 1
- 208000019568 Shared Paranoid disease Diseases 0.000 description 1
- 208000028810 Shared psychotic disease Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041250 Social phobia Diseases 0.000 description 1
- 206010072005 Spinal pain Diseases 0.000 description 1
- 208000035286 Spontaneous Remission Diseases 0.000 description 1
- 208000013200 Stress disease Diseases 0.000 description 1
- 241001279009 Strychnos toxifera Species 0.000 description 1
- 208000003028 Stuttering Diseases 0.000 description 1
- 208000011962 Substance-induced mood disease Diseases 0.000 description 1
- 231100000395 Substance-induced mood disorder Toxicity 0.000 description 1
- 208000011963 Substance-induced psychotic disease Diseases 0.000 description 1
- 231100000393 Substance-induced psychotic disorder Toxicity 0.000 description 1
- 102100031274 Translocator protein Human genes 0.000 description 1
- 101710166801 Translocator protein Proteins 0.000 description 1
- 208000030886 Traumatic Brain injury Diseases 0.000 description 1
- 229960001157 acamprosate calcium Drugs 0.000 description 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
- 229960004373 acetylcholine Drugs 0.000 description 1
- 230000001919 adrenal effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000003281 allosteric effect Effects 0.000 description 1
- VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 230000000049 anti-anxiety effect Effects 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 239000003420 antiserotonin agent Substances 0.000 description 1
- 230000007529 anxiety like behavior Effects 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 239000003693 atypical antipsychotic agent Substances 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 208000018300 basal ganglia disease Diseases 0.000 description 1
- 230000003542 behavioural effect Effects 0.000 description 1
- 239000002876 beta blocker Substances 0.000 description 1
- WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 208000028683 bipolar I disease Diseases 0.000 description 1
- 208000022257 bipolar II disease Diseases 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 230000008344 brain blood flow Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000009460 calcium influx Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000013216 cat model Methods 0.000 description 1
- 210000001159 caudate nucleus Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 description 1
- 229960004606 clomipramine Drugs 0.000 description 1
- 238000011260 co-administration Methods 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
- 229960000258 corticotropin Drugs 0.000 description 1
- 235000019788 craving Nutrition 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 208000026725 cyclothymic disease Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000003001 depressive effect Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 229960003957 dexamethasone Drugs 0.000 description 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 229940052760 dopamine agonists Drugs 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 230000003291 dopaminomimetic effect Effects 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 208000010118 dystonia Diseases 0.000 description 1
- 239000006274 endogenous ligand Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000002461 excitatory amino acid Effects 0.000 description 1
- 239000003257 excitatory amino acid Substances 0.000 description 1
- 230000009540 excitatory neurotransmission Effects 0.000 description 1
- 230000036749 excitatory postsynaptic potential Effects 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 210000005153 frontal cortex Anatomy 0.000 description 1
- 210000001652 frontal lobe Anatomy 0.000 description 1
- 230000009760 functional impairment Effects 0.000 description 1
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 1
- 230000028579 gamma-aminobutyric acid uptake involved in synaptic transmission Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000029364 generalized anxiety disease Diseases 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 210000001905 globus pallidus Anatomy 0.000 description 1
- 229940049906 glutamate Drugs 0.000 description 1
- 230000000848 glutamatergic effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000001320 hippocampus Anatomy 0.000 description 1
- 230000009610 hypersensitivity Effects 0.000 description 1
- 230000003528 hypoglutamatergic effect Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000005032 impulse control Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000031891 intestinal absorption Effects 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 150000002634 lipophilic molecules Chemical class 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 230000000897 modulatory effect Effects 0.000 description 1
- 201000005518 mononeuropathy Diseases 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 229960004127 naloxone Drugs 0.000 description 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 description 1
- 230000008279 neurobiological mechanism Effects 0.000 description 1
- 230000007996 neuronal plasticity Effects 0.000 description 1
- 238000010855 neuropsychological testing Methods 0.000 description 1
- 230000003957 neurotransmitter release Effects 0.000 description 1
- 230000006959 non-competitive inhibition Effects 0.000 description 1
- 230000002474 noradrenergic effect Effects 0.000 description 1
- 231100000862 numbness Toxicity 0.000 description 1
- 210000004789 organ system Anatomy 0.000 description 1
- 208000027753 pain disease Diseases 0.000 description 1
- 230000037324 pain perception Effects 0.000 description 1
- 208000002851 paranoid schizophrenia Diseases 0.000 description 1
- 229960002296 paroxetine Drugs 0.000 description 1
- 230000001991 pathophysiological effect Effects 0.000 description 1
- 230000009914 physiological arousal Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 210000000976 primary motor cortex Anatomy 0.000 description 1
- 229940124811 psychiatric drug Drugs 0.000 description 1
- 230000008433 psychological processes and functions Effects 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000001739 rebound effect Effects 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 230000001020 rhythmical effect Effects 0.000 description 1
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 description 1
- 229960001534 risperidone Drugs 0.000 description 1
- 208000015212 rumination disease Diseases 0.000 description 1
- 230000000698 schizophrenic effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000000697 serotonin reuptake Effects 0.000 description 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 description 1
- 238000002603 single-photon emission computed tomography Methods 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- AEQFSUDEHCCHBT-UHFFFAOYSA-M sodium valproate Chemical compound [Na+].CCCC(C([O-])=O)CCC AEQFSUDEHCCHBT-UHFFFAOYSA-M 0.000 description 1
- 230000008914 somatic perception Effects 0.000 description 1
- 201000001716 specific phobia Diseases 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000008925 spontaneous activity Effects 0.000 description 1
- 239000000021 stimulant Substances 0.000 description 1
- 229960005453 strychnine Drugs 0.000 description 1
- 230000002739 subcortical effect Effects 0.000 description 1
- 230000007428 synaptic transmission, GABAergic Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000542 thalamic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000003325 tomography Methods 0.000 description 1
- 238000002646 transcutaneous electrical nerve stimulation Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000009529 traumatic brain injury Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 231100000402 unacceptable toxicity Toxicity 0.000 description 1
- 229940102566 valproate Drugs 0.000 description 1
- 230000001755 vocal effect Effects 0.000 description 1
- 238000004018 waxing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/273,036 | 1999-03-19 | ||
| US09/273,036 US6391922B1 (en) | 1998-01-13 | 1999-03-19 | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
| PCT/US2000/007119 WO2000056301A2 (en) | 1999-03-19 | 2000-03-17 | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2367015A1 true CA2367015A1 (en) | 2000-09-28 |
Family
ID=23042279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002367015A Abandoned CA2367015A1 (en) | 1999-03-19 | 2000-03-17 | Methods of treating tardive dyskinesia and other movement disorders |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6391922B1 (enExample) |
| EP (1) | EP1162960A2 (enExample) |
| JP (1) | JP4633262B2 (enExample) |
| AU (1) | AU3895000A (enExample) |
| CA (1) | CA2367015A1 (enExample) |
| WO (1) | WO2000056301A2 (enExample) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6391922B1 (en) * | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
| US20020022657A1 (en) * | 1998-02-11 | 2002-02-21 | Francine Gervais | Methods for modulating neuronal cell death |
| EP1852113A3 (en) * | 2000-12-07 | 2008-03-12 | Neuromolecular Inc. | Methods for treating neuropsychiatric disorders with NMDA receptors antagonists |
| EP1383465B1 (en) * | 2001-03-29 | 2011-08-10 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with d-cycloserine |
| US6462084B1 (en) * | 2001-05-14 | 2002-10-08 | Brookhaven Science Associates, Llc | Treatment for obsessive-compulsive disorder (OCD) and OCD-related disorders using GVG |
| US20030045541A1 (en) * | 2001-07-23 | 2003-03-06 | Christopher Bruckner | GABA-Receptor modulators with NMDA-Antagonistic activity |
| US20040034106A1 (en) * | 2001-11-06 | 2004-02-19 | Read Holly Ann | Treatment of anxiety disorders |
| EP1471909A4 (en) * | 2002-01-16 | 2007-07-25 | Endo Pharmaceuticals Inc | PHARMACEUTICAL COMPOSITION AND METHOD FOR THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM |
| WO2004093910A1 (ja) * | 2003-04-22 | 2004-11-04 | Astellas Pharma Inc. | PPARδアゴニストによる脳神経変性疾患治療剤 |
| US7422753B2 (en) * | 2003-04-25 | 2008-09-09 | Allergan, Inc. | Methods for treating trichotillomania |
| US7393537B2 (en) * | 2003-04-25 | 2008-07-01 | Allergan, Inc. | Botulinum toxin for treatment of obsessive compulsive finger biting disorder |
| US7396535B2 (en) * | 2003-04-25 | 2008-07-08 | Ackerman Alan H | Therapy for obsessive compulsive head banging |
| US7390496B2 (en) * | 2003-04-25 | 2008-06-24 | Allergan, Inc. | Therapeutic treatments for repetitive hand washing |
| US8617572B2 (en) | 2003-10-29 | 2013-12-31 | Allergan, Inc. | Botulinum toxin treatments of depression |
| US8734810B2 (en) | 2003-10-29 | 2014-05-27 | Allergan, Inc. | Botulinum toxin treatments of neurological and neuropsychiatric disorders |
| US8609112B2 (en) | 2003-10-29 | 2013-12-17 | Allergan, Inc. | Botulinum toxin treatments of depression |
| US8609113B2 (en) | 2003-10-29 | 2013-12-17 | Allergan, Inc. | Botulinum toxin treatments of depression |
| EP1701730B1 (en) * | 2003-12-09 | 2013-08-21 | Yeda Research And Development Co., Ltd. | Method and vaccine comprising copolymer 1 for treatment of psychiatric disorders |
| US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| WO2006066197A1 (en) * | 2004-12-17 | 2006-06-22 | Janssen Pharmaceutica, N.V. | Tetrahydroisoquinoline compounds for treatment of cns disorders |
| US20060167068A1 (en) * | 2005-01-26 | 2006-07-27 | Seth Feuerstein | Method of treating self-injurious behavior with glutamate modulating agents |
| PL2982372T3 (pl) | 2005-04-05 | 2020-12-28 | Yale University | Środki modulujące stężenie glutaminianu stosowane w leczeniu zaburzeń psychicznych |
| EP1874282B1 (en) | 2005-04-06 | 2010-09-15 | Adamas Pharmaceuticals, Inc. | Methods and compositions for treatment of cns disorders |
| US20060252830A1 (en) * | 2005-05-06 | 2006-11-09 | Brandon Stephen F | Method for the treatment of magnesium and potassium deficiencies |
| US20060252831A1 (en) * | 2005-05-06 | 2006-11-09 | Christopher Offen | Method for the treatment of magnesium and potassium deficiencies |
| KR20080059208A (ko) * | 2005-09-16 | 2008-06-26 | 세레우사이언스 아베 | 수면 호흡 장애를 예방 및 치료하는 방법과 그 수단 |
| MX2008008213A (es) * | 2005-12-22 | 2008-09-03 | Neurochem Int Ltd | Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias. |
| MX2009006768A (es) * | 2006-12-22 | 2009-08-31 | Bellus Health Int Ltd | Metodos, compuestos, y composiciones para tratar trastornos metabolicos y diabetes. |
| WO2008086483A2 (en) * | 2007-01-11 | 2008-07-17 | Braincells, Inc. | Modulation of neurogenesis with use of modafinil |
| US20090104160A1 (en) * | 2007-02-01 | 2009-04-23 | Moraga Biotechnology Corporation | Mobilization of Stem Cells After Trauma and Methods Therefor |
| NZ583193A (en) * | 2007-07-23 | 2012-05-25 | Biotie Therapies Inc | Treatment of post-traumatic stress disorder with nepicastat |
| US20090082464A1 (en) * | 2007-09-07 | 2009-03-26 | Bernd Jandeleit | Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| US8168617B2 (en) * | 2007-09-07 | 2012-05-01 | Xenoport, Inc. | Complex pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| US20090099253A1 (en) * | 2007-10-15 | 2009-04-16 | Xenoport, Inc. | Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use |
| US20090156886A1 (en) * | 2007-12-12 | 2009-06-18 | Synapse Research Company | Method and apparatus for providing automatic eye focused therapy |
| EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
| ES2530047T3 (es) | 2009-02-12 | 2015-02-26 | Indiana University Research And Technology Corporation | Material y métodos para el tratamiento de trastornos del desarrollo que incluyen autismo idiopático y comórbido |
| EP2482838A4 (en) | 2009-09-30 | 2013-04-10 | Toxcure Inc | USE OF BOTULINUM NEUROTOXIN FOR THE TREATMENT OF SUBSTANCE DEPENDENCE |
| EP2322163A1 (en) | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
| CA2850468C (en) | 2010-09-28 | 2019-08-13 | Depomed, Inc. | Gastric retentive dosage forms for extended release of acamprosate into the upper gastrointestinal tract |
| MX383953B (es) | 2010-11-15 | 2025-03-14 | Agenebio Inc | Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo. |
| EP2705842A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| CN108057033A (zh) * | 2011-03-01 | 2018-05-22 | 法耐斯特公司 | 用于治疗肌萎缩性侧索硬化症的新组合物 |
| US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| TR201809351T4 (tr) * | 2011-03-01 | 2018-07-23 | Pharnext | Nörolojik bozuklukların baklofen ve akamprosat tabanlı terapisi. |
| US20130143867A1 (en) | 2011-12-02 | 2013-06-06 | Sychroneuron Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
| MX2015002378A (es) * | 2012-08-23 | 2015-09-25 | Stuart L Weg | Composicion ansiolitica, formulacion y metodo de uso. |
| CN105431144A (zh) | 2013-06-05 | 2016-03-23 | 思康脑侒股份有限公司 | 阿坎酸制剂、使用阿坎酸制剂的方法以及包含阿坎酸制剂的组合 |
| MX381561B (es) | 2013-12-20 | 2025-03-12 | Agenebio Inc | Derivados de benzodiazepina, composiciones, y métodos para tratar el deterioro cognitivo. |
| US9717903B1 (en) * | 2015-03-17 | 2017-08-01 | Gary Barrett | Electronic process to restore, improve and/or strengthen the libido; method to mend the sex drive in males and females |
| US10431109B2 (en) * | 2015-06-03 | 2019-10-01 | Cambia Health Solutions, Inc. | Systems and methods for somatization identification and treatment |
| US10815242B2 (en) | 2015-06-19 | 2020-10-27 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US11505555B2 (en) | 2016-12-19 | 2022-11-22 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| JP7312116B2 (ja) | 2017-05-25 | 2023-07-20 | グリテック, エルエルシー | 外傷後ストレス障害の治療用の製剤 |
| US10682086B2 (en) * | 2017-09-12 | 2020-06-16 | AebeZe Labs | Delivery of a digital therapeutic method and system |
| US11157700B2 (en) * | 2017-09-12 | 2021-10-26 | AebeZe Labs | Mood map for assessing a dynamic emotional or mental state (dEMS) of a user |
| CA3104478A1 (en) | 2018-06-19 | 2019-12-26 | Agenebio, Inc. | Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment |
| US11694786B1 (en) * | 2019-01-04 | 2023-07-04 | Yasmine Van Wilt | Recommendation methods, systems and devices |
| TW202139981A (zh) | 2020-01-22 | 2021-11-01 | 美商西羅斯醫療公司 | 降低nmda拮抗劑之副作用 |
| WO2025106574A1 (en) | 2023-11-14 | 2025-05-22 | Aardwolf Therapeutics, Inc. | Flumazenil for treating post-traumatic stress disorder and anxiety |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2457281A1 (fr) | 1979-05-23 | 1980-12-19 | Meram Lab | Nouveaux derives de l'acide 3-aminopropanesulfonique ayant une activite membranaire renforcee |
| US4745126A (en) | 1987-03-12 | 1988-05-17 | Eli Lilly And Company | Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides |
| US4985256A (en) | 1988-04-27 | 1991-01-15 | Bionix Corporation | Methods for diagnosing, monitoring and controlling the onset and progression of certain dementias and impeding memory loss or improving impairment of memory |
| US4962128A (en) | 1989-11-02 | 1990-10-09 | Pfizer Inc. | Method of treating anxiety-related disorders using sertraline |
| US5028612A (en) | 1990-03-22 | 1991-07-02 | Hillel Glover | Method for treating emotional numbness |
| US5086072A (en) | 1990-06-18 | 1992-02-04 | The United States Of America As Represented By The Department Of Health And Human Services | Treatment of mood disorders with functional antagonists of the glycine/nmda receptor complex |
| US5145866A (en) | 1991-04-22 | 1992-09-08 | Hoechst-Roussel Pharmaceuticals Incorporated | Method of treating anxiety with the aid of r(+)-3-amino-1-hydroxy-pyrrolidin-2-one |
| US5602150A (en) | 1992-10-02 | 1997-02-11 | Research Foundation For Mental Hygiene, Inc. | Treatment of central nervous system disorders associated with psychotic behavior and dementia with a combination of neuroleptic drugs and taurine, or derivatives thereof, to prevent the development of tardive dyskinesia |
| US5356902A (en) | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
| US5475019A (en) | 1993-02-08 | 1995-12-12 | East Carolina University | Method of treating anxiety-related disorders with 2-aminocycloaliphatic amide compounds |
| US5475007A (en) | 1993-05-28 | 1995-12-12 | The Regents Of The University Of California | 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof |
| US5665757A (en) | 1994-07-13 | 1997-09-09 | Robert W. Dunn | Method for treating anxiety |
| US5597922A (en) | 1994-07-29 | 1997-01-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Glycine receptor antagonist pharmacophore |
| US6562862B1 (en) | 1994-10-20 | 2003-05-13 | Eli Lilly And Company | Methods of inhibiting physiological conditions associated with an excess of neuropeptide Y |
| US5484794A (en) | 1994-11-09 | 1996-01-16 | Eli Lilly And Company | Method for treating anxiety |
| US5488056A (en) | 1994-10-31 | 1996-01-30 | Eli Lilly And Company | Method for treating anxiety |
| US5726193A (en) | 1994-10-31 | 1998-03-10 | Eli Lilly And Company | Method for treating anxiety |
| US5574028A (en) | 1994-10-31 | 1996-11-12 | Eli Lilly And Company | Method for treating anxiety |
| US5476933A (en) | 1994-11-16 | 1995-12-19 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | Azepine synthesis via a diels-alder reaction |
| US5614508A (en) | 1995-06-07 | 1997-03-25 | Warner-Lambert Company | Amino acid derivatives of substituted quinoxaline 2,3-dione derivatives as glutamate receptor antagonists |
| US5654303A (en) | 1995-06-07 | 1997-08-05 | Warner-Lambert Company | Alkyl amine derivatives of substituted quinoxaline 2,3-diones as glutamate receptor antagonists |
| US5852037A (en) | 1995-11-13 | 1998-12-22 | Eli Lilly And Company | Method for treating anxiety |
| US5763457A (en) | 1995-11-13 | 1998-06-09 | Eli Lilly And Company | Method for treating anxiety |
| US5681578A (en) | 1996-01-22 | 1997-10-28 | Sahley; Billie J. | Composition for relieving stress anxiety, grief, and depression |
| US5776969A (en) | 1997-02-27 | 1998-07-07 | Eli Lilly And Company | Treatment of sleep disorders |
| US5866585A (en) | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
| US5883083A (en) | 1997-06-09 | 1999-03-16 | Harlmen, Inc. | Dietary supplement for alleviating behavioral problems in canines and reducing seizures in canines and felines |
| US6294583B1 (en) | 1998-01-13 | 2001-09-25 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders |
| EP1047436B1 (en) | 1998-01-13 | 2009-10-21 | Synchroneuron, LLC | N-acetylhomotaurinates for use in treating hyperkinesias |
| US6391922B1 (en) * | 1998-01-13 | 2002-05-21 | Synchroneuron, Llc | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders |
-
1999
- 1999-03-19 US US09/273,036 patent/US6391922B1/en not_active Expired - Lifetime
-
2000
- 2000-03-17 WO PCT/US2000/007119 patent/WO2000056301A2/en not_active Ceased
- 2000-03-17 JP JP2000606206A patent/JP4633262B2/ja not_active Expired - Lifetime
- 2000-03-17 EP EP00918076A patent/EP1162960A2/en not_active Withdrawn
- 2000-03-17 AU AU38950/00A patent/AU3895000A/en not_active Abandoned
- 2000-03-17 CA CA002367015A patent/CA2367015A1/en not_active Abandoned
-
2002
- 2002-03-01 US US10/087,357 patent/US6689816B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000056301A2 (en) | 2000-09-28 |
| US6689816B2 (en) | 2004-02-10 |
| WO2000056301A3 (en) | 2000-12-28 |
| JP4633262B2 (ja) | 2011-02-16 |
| EP1162960A2 (en) | 2001-12-19 |
| US6391922B1 (en) | 2002-05-21 |
| US20020119912A1 (en) | 2002-08-29 |
| AU3895000A (en) | 2000-10-09 |
| JP2002539245A (ja) | 2002-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6689816B2 (en) | Treatment of posttraumatic stress disorder, obsessive-compulsive disorder and related neuropsychiatric disorders | |
| US6294583B1 (en) | Methods of treating tardive dyskinesia and other movement disorders | |
| US6057373A (en) | Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists | |
| Addolorato et al. | Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation | |
| EP1047436B1 (en) | N-acetylhomotaurinates for use in treating hyperkinesias | |
| WO2013007698A1 (en) | Pharmaceutical composition for neurological disorders | |
| US20060252761A1 (en) | Augmentation of extinction via administration of sub-antimicrobial doses of D-cycloserine | |
| JP2009517393A (ja) | 不安症の治療方法 | |
| Lippiello et al. | From cannabis to cannabidiol to treat epilepsy, where are we? | |
| Karabin et al. | The monoamine theory of depression as a target to effective pharmacotherapy | |
| CA2444269C (en) | Treatment of disorders secondary to organic impairments | |
| EP2168584B1 (en) | Pharmaceutical composition comprising the combination of a triazolobenzodiazepine and a selective serotonin reuptake inhibitor | |
| AU2002258820A1 (en) | Treatment of disorders secondary to organic impairments | |
| Stock et al. | Pharmacological treatment of paediatric | |
| MXPA01009484A (es) | Tratamiento de trastorno de estres post-traumatico, trastorno obsesivo-compulsivo y trastornos neuropsiquiatricos relacionados | |
| MXPA01001179A (es) | Metodos y composiciones para el uso de la moclobemida. | |
| US20120225916A1 (en) | Compositions and Methods to Improve Treatment of Medical Conditions Using D-Cycloserine | |
| Troppoli | Fast and Furious: Identifying the Target Engagement and Mechanisms Underlying the Rapid Behavioral and Synaptic Actions of Mrk-016, a Negative Allosteric Modulator of Αlpha5-Containing Gabaars, and the Commonalities with Other Fast-Acting Antidepressant Compounds | |
| Clark | Headaches and Chronic Pain | |
| EP2047852A1 (en) | Use of flumazenil in the production of a medicament for the treatment of depressive disorders | |
| Cassidy | rehabilitation of patients with traumatic brain injury | |
| MXPA00006716A (en) | Methods of treating tardive dyskinesia and other movement disorders |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |