CA2366707A1 - Transplantation de moelle osseuse pour la regeneration et la reparation hepatique - Google Patents

Transplantation de moelle osseuse pour la regeneration et la reparation hepatique Download PDF

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Publication number
CA2366707A1
CA2366707A1 CA002366707A CA2366707A CA2366707A1 CA 2366707 A1 CA2366707 A1 CA 2366707A1 CA 002366707 A CA002366707 A CA 002366707A CA 2366707 A CA2366707 A CA 2366707A CA 2366707 A1 CA2366707 A1 CA 2366707A1
Authority
CA
Canada
Prior art keywords
cells
oval
liver
bone marrow
hepatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002366707A
Other languages
English (en)
Inventor
Bryon E. Petersen
Julie P. Goff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2366707A1 publication Critical patent/CA2366707A1/fr
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention porte sur des procédés et des compositions permettant de stimuler la régénération du foie chez des sujets souffrant de troubles du foie. Plus particulièrement, les procédés et les compositions décrits dans la présente invention sont utiles pour la transplantation de cellules de moelle osseuse sur un hôte receveur en quantités suffisantes pour permettre la production d'hépatocytes, de cellules biliaires canalaires et de cellules ovales pendant la régénération du foie. Cette invention est basée sur le constat selon lequel les cellules dérivées de la moelle osseuse peuvent jouer un rôle actif dans la production d'hépatocytes, de cellules biliaires canalaires et de cellules ovales pendant la régénération du foie. En outre, cette invention porte sur des procédés utilisés pour dériver des populations enrichies de cellules ovales hépatiques, considérées comme étant des cellules souches hépatiques, à l'aide d'anticorps capables de reconnaître l'antigène de surface cellulaire Thy-1 exprimé à la surface des cellules ovales hépatiques. On peut transplanter les populations enrichies de cellules ovales hépatiques sur un hôte afin de stimuler la régénération du foie chez les sujets souffrant de troubles du foie.
CA002366707A 1999-02-26 2000-02-25 Transplantation de moelle osseuse pour la regeneration et la reparation hepatique Abandoned CA2366707A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12225099P 1999-02-26 1999-02-26
US60/122,250 1999-02-26
PCT/US2000/004744 WO2000050048A2 (fr) 1999-02-26 2000-02-25 Transplantation de moelle osseuse pour la regeneration et la reparation hepatique

Publications (1)

Publication Number Publication Date
CA2366707A1 true CA2366707A1 (fr) 2000-08-31

Family

ID=22401591

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002366707A Abandoned CA2366707A1 (fr) 1999-02-26 2000-02-25 Transplantation de moelle osseuse pour la regeneration et la reparation hepatique

Country Status (4)

Country Link
EP (1) EP1154780A2 (fr)
AU (1) AU3376300A (fr)
CA (1) CA2366707A1 (fr)
WO (1) WO2000050048A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US7473555B2 (en) 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
US7282366B2 (en) 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
US6458589B1 (en) * 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
WO2004016747A2 (fr) * 2002-08-14 2004-02-26 University Of Florida Differenciation de cellules de moelle osseuse
WO2004030628A2 (fr) * 2002-10-02 2004-04-15 New York University Cellules souches derivees de la moelle osseuse adulte
WO2004035761A2 (fr) 2002-10-18 2004-04-29 University Of Florida Differenciation de cellules de la moelle osseuse
EP2387998A1 (fr) * 2003-04-29 2011-11-23 Glaxosmithkline LLC Procédés de traitement de maladies/lésions dégénératives
CA2535680A1 (fr) 2003-08-11 2005-02-24 University Of South Florida Cellules vigilantes
US7332336B2 (en) 2003-08-19 2008-02-19 Effector Cell Institute, Inc. Methods for inducing differentiation of pluripotent cells
JP4563705B2 (ja) * 2004-03-19 2010-10-13 グンゼ株式会社 胆管組織再生用基材
EP2024492B1 (fr) 2006-06-02 2017-03-29 Asterias Biotherapeutics, Inc. Différentiation de cellules pluripotentes de primates en cellules de lignées hépatocytaires
ES2520044T3 (es) 2007-03-30 2014-11-11 The Cleveland Clinic Foundation SDF-1 para su uso en el tratamiento de trastornos vasculares periféricos isquémicos
CA2709398C (fr) 2007-12-14 2017-11-07 The Cleveland Clinic Foundation Utilisation du facteur 1 derive de cellules stromales afin de favoriser la guerison des plaies
CA2772610C (fr) 2009-08-28 2018-01-23 The Cleveland Clinic Foundation Administration de sdf-1 en vue du traitement de tissus ischemiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018972A1 (fr) * 1990-05-30 1991-12-12 Cellco, Inc. Culture de cellules de moelle osseuse utilisees en immunotherapie adoptive
EP1559778A1 (fr) * 1991-08-07 2005-08-03 Albert Einstein College Of Medicine Of Yeshiva University Prolifération de précurseurs d'hépatocytes
AU2590399A (en) * 1998-02-09 1999-08-23 Gere Dizerega Method of promoting hepatic cell proliferation

Also Published As

Publication number Publication date
WO2000050048A2 (fr) 2000-08-31
WO2000050048A3 (fr) 2001-02-01
EP1154780A2 (fr) 2001-11-21
AU3376300A (en) 2000-09-14
WO2000050048A9 (fr) 2002-03-14

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FZDE Dead