WO2000050048A3 - Transplantation de moelle osseuse pour la regeneration et la reparation hepatique - Google Patents

Transplantation de moelle osseuse pour la regeneration et la reparation hepatique Download PDF

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Publication number
WO2000050048A3
WO2000050048A3 PCT/US2000/004744 US0004744W WO0050048A3 WO 2000050048 A3 WO2000050048 A3 WO 2000050048A3 US 0004744 W US0004744 W US 0004744W WO 0050048 A3 WO0050048 A3 WO 0050048A3
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WO
WIPO (PCT)
Prior art keywords
cells
hepatic
liver regeneration
bone marrow
oval
Prior art date
Application number
PCT/US2000/004744
Other languages
English (en)
Other versions
WO2000050048A9 (fr
WO2000050048A2 (fr
Inventor
Bryon E Petersen
Julie P Goff
Original Assignee
Univ Pittsburgh
Bryon E Petersen
Julie P Goff
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh, Bryon E Petersen, Julie P Goff filed Critical Univ Pittsburgh
Priority to EP00911954A priority Critical patent/EP1154780A2/fr
Priority to CA002366707A priority patent/CA2366707A1/fr
Priority to AU33763/00A priority patent/AU3376300A/en
Publication of WO2000050048A2 publication Critical patent/WO2000050048A2/fr
Publication of WO2000050048A3 publication Critical patent/WO2000050048A3/fr
Publication of WO2000050048A9 publication Critical patent/WO2000050048A9/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention porte sur des procédés et des compositions permettant de stimuler la régénération du foie chez des sujets souffrant de troubles du foie. Plus particulièrement, les procédés et les compositions décrits dans la présente invention sont utiles pour la transplantation de cellules de moelle osseuse sur un hôte receveur en quantités suffisantes pour permettre la production d'hépatocytes, de cellules biliaires canalaires et de cellules ovales pendant la régénération du foie. Cette invention est basée sur le constat selon lequel les cellules dérivées de la moelle osseuse peuvent jouer un rôle actif dans la production d'hépatocytes, de cellules biliaires canalaires et de cellules ovales pendant la régénération du foie. En outre, cette invention porte sur des procédés utilisés pour dériver des populations enrichies de cellules ovales hépatiques, considérées comme étant des cellules souches hépatiques, à l'aide d'anticorps capables de reconnaître l'antigène de surface cellulaire Thy-1 exprimé à la surface des cellules ovales hépatiques. On peut transplanter les populations enrichies de cellules ovales hépatiques sur un hôte afin de stimuler la régénération du foie chez les sujets souffrant de troubles du foie.
PCT/US2000/004744 1999-02-26 2000-02-25 Transplantation de moelle osseuse pour la regeneration et la reparation hepatique WO2000050048A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00911954A EP1154780A2 (fr) 1999-02-26 2000-02-25 Transplantation de moelle osseuse pour la regeneration et la reparation hepatique
CA002366707A CA2366707A1 (fr) 1999-02-26 2000-02-25 Transplantation de moelle osseuse pour la regeneration et la reparation hepatique
AU33763/00A AU3376300A (en) 1999-02-26 2000-02-25 Bone marrow transplantation for hepatic regeneration and repair

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12225099P 1999-02-26 1999-02-26
US60/122,250 1999-03-03

Publications (3)

Publication Number Publication Date
WO2000050048A2 WO2000050048A2 (fr) 2000-08-31
WO2000050048A3 true WO2000050048A3 (fr) 2001-02-01
WO2000050048A9 WO2000050048A9 (fr) 2002-03-14

Family

ID=22401591

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004744 WO2000050048A2 (fr) 1999-02-26 2000-02-25 Transplantation de moelle osseuse pour la regeneration et la reparation hepatique

Country Status (4)

Country Link
EP (1) EP1154780A2 (fr)
AU (1) AU3376300A (fr)
CA (1) CA2366707A1 (fr)
WO (1) WO2000050048A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
US6458589B1 (en) * 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
US7282366B2 (en) 2000-04-27 2007-10-16 Geron Corporation Hepatocytes for therapy and drug screening made from embryonic stem cells
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
US7473555B2 (en) 2000-04-27 2009-01-06 Geron Corporation Protocols for making hepatocytes from embryonic stem cells
WO2004016747A2 (fr) * 2002-08-14 2004-02-26 University Of Florida Differenciation de cellules de moelle osseuse
US20040136969A1 (en) * 2002-10-02 2004-07-15 New York University Adult bone marrow derived stem cells
WO2004035761A2 (fr) 2002-10-18 2004-04-29 University Of Florida Differenciation de cellules de la moelle osseuse
WO2004096154A2 (fr) * 2003-04-29 2004-11-11 Smithkline Beecham Corporation Procedes de traitement de maladies/lesions degeneratives
CA2535683A1 (fr) 2003-08-11 2005-02-24 University Of South Florida Balise de cellule souche
US7332336B2 (en) 2003-08-19 2008-02-19 Effector Cell Institute, Inc. Methods for inducing differentiation of pluripotent cells
JP4563705B2 (ja) * 2004-03-19 2010-10-13 グンゼ株式会社 胆管組織再生用基材
US8148151B2 (en) 2006-06-02 2012-04-03 Geron Corporation Differentiation of primate pluripotent cells to hepatocyte-lineage cells
ES2520044T3 (es) 2007-03-30 2014-11-11 The Cleveland Clinic Foundation SDF-1 para su uso en el tratamiento de trastornos vasculares periféricos isquémicos
WO2009079451A2 (fr) 2007-12-14 2009-06-25 The Cleveland Clinic Foundation Compositions et procédés pour favoriser la guérison d'une plaie
WO2011026041A2 (fr) 2009-08-28 2011-03-03 The Cleveland Clinic Foundation Administration de sdf-1 en vue du traitement de tissus ischémiques

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018972A1 (fr) * 1990-05-30 1991-12-12 Cellco, Inc. Culture de cellules de moelle osseuse utilisees en immunotherapie adoptive
US5789246A (en) * 1991-08-07 1998-08-04 Albert Einstein College Of Medicine Compositions comprising hepatocyte precursors
WO1999039743A2 (fr) * 1998-02-09 1999-08-12 University Of Southern California Procede de stimulation de la proliferation des cellules hepatiques

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991018972A1 (fr) * 1990-05-30 1991-12-12 Cellco, Inc. Culture de cellules de moelle osseuse utilisees en immunotherapie adoptive
US5789246A (en) * 1991-08-07 1998-08-04 Albert Einstein College Of Medicine Compositions comprising hepatocyte precursors
WO1999039743A2 (fr) * 1998-02-09 1999-08-12 University Of Southern California Procede de stimulation de la proliferation des cellules hepatiques

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALISON MALCOLM ET AL: "Wound healing in the liver with particular reference to stem cells.", PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON B BIOLOGICAL, vol. 353, no. 1370, 29 June 1998 (1998-06-29), June 29, 1998, pages 877 - 894, XP000946107, ISSN: 0962-8436 *
PETERSEN B E ET AL: "Bone marrow as a potential source of hepatic oval cells.", SCIENCE (WASHINGTON D C), vol. 284, no. 5417, 14 May 1999 (1999-05-14), pages 1168 - 1170, XP002147735, ISSN: 0036-8075 *
PETERSEN BRYON E ET AL: "Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat.", HEPATOLOGY, vol. 27, no. 2, February 1998 (1998-02-01), pages 433 - 445, XP000946076, ISSN: 0270-9139 *
PETERSEN BRYON E ET AL: "Thy-1+ sorted hepatic oval cells in culture maintain oval cell phenotypic markers.", FASEB JOURNAL, vol. 12, no. 4, 17 March 1998 (1998-03-17), pages A468, XP002147734, ISSN: 0892-6638 *
YASUI OUKI ET AL: "Isolation of oval cells from Long-Evans Cinnamon rats and their transformation into hepatocytes in vivo in the rat liver.", HEPATOLOGY, vol. 25, no. 2, 1997, pages 329 - 334, XP000946193, ISSN: 0270-9139 *

Also Published As

Publication number Publication date
EP1154780A2 (fr) 2001-11-21
CA2366707A1 (fr) 2000-08-31
AU3376300A (en) 2000-09-14
WO2000050048A9 (fr) 2002-03-14
WO2000050048A2 (fr) 2000-08-31

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