CA2365915C - Recombinant toxin a/toxin b vaccine against clostridium difficile - Google Patents
Recombinant toxin a/toxin b vaccine against clostridium difficile Download PDFInfo
- Publication number
- CA2365915C CA2365915C CA2365915A CA2365915A CA2365915C CA 2365915 C CA2365915 C CA 2365915C CA 2365915 A CA2365915 A CA 2365915A CA 2365915 A CA2365915 A CA 2365915A CA 2365915 C CA2365915 C CA 2365915C
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- Prior art keywords
- asn
- toxin
- gly
- ile
- protein
- Prior art date
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| US60/190,111 | 2000-03-20 | ||
| PCT/US2000/009525 WO2000061762A1 (en) | 1999-04-09 | 2000-04-10 | RECOMBINANT TOXIN A/TOXIN B VACCINE AGAINST $i(CLOSTRIDIUM DIFFICILE) |
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| GB0205206D0 (en) * | 2002-03-06 | 2002-04-17 | Oxoid Ltd | Synthetic peptides |
| US6912151B2 (en) | 2002-06-28 | 2005-06-28 | Synopsys, Inc. | Negative differential resistance (NDR) based memory device with reduced body effects |
| UA105508C2 (uk) * | 2008-12-03 | 2014-05-26 | Бьорінгер Інгельхайм Ветмедіка Гмбх | Спосіб одержання вакцини проти clostridium difficile |
| PL2753352T5 (pl) | 2010-09-03 | 2022-10-17 | Valneva Austria Gmbh | Izolowany polipeptyd białek toksyny a i toksyny b z c. difficile i jego zastosowania |
| GB201016742D0 (en) | 2010-10-05 | 2010-11-17 | Health Prot Agency | Clostridium difficile antigens |
| TWI815599B (zh) | 2011-04-22 | 2023-09-11 | 美商惠氏有限責任公司 | 與難養芽胞梭菌（Ｃｌｏｓｔｒｉｄｉｕｍ ｄｉｆｆｉｃｉｌｅ）之突變毒素有關之組成物及彼之方法 |
| AU2016203241B2 (en) * | 2011-05-27 | 2018-05-10 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| HUE037126T2 (hu) | 2011-05-27 | 2018-08-28 | Glaxosmithkline Biologicals Sa | Immunogén készítmény |
| WO2013084071A2 (en) | 2011-12-08 | 2013-06-13 | Novartis Ag | Clostridium difficile toxin-based vaccine |
| GB201206070D0 (en) * | 2012-04-04 | 2012-05-16 | Health Prot Agency | Clostridium difficile antigens |
| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| WO2014086787A1 (en) | 2012-12-05 | 2014-06-12 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| ES2750525T3 (es) | 2012-12-27 | 2020-03-26 | Glaxosmithkline Biologicals Sa | Procedimientos y composiciones relacionados con CRM197 |
| BE1022949B1 (fr) * | 2014-06-25 | 2016-10-21 | Glaxosmithkline Biologicals S.A. | Composition immunogene |
| CA2976976C (en) | 2015-02-19 | 2023-02-28 | Immune Biosolutions Inc. | Clostridium difficile toxins a and/or b antigen and epitope antibody, and pharmaceutical uses thereof |
| US12076352B2 (en) | 2018-06-19 | 2024-09-03 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| CN113329766A (zh) * | 2018-11-16 | 2021-08-31 | 马特里瓦克斯公司 | 艰难梭菌多组分疫苗 |
| WO2021255690A2 (en) | 2020-06-19 | 2021-12-23 | Pfizer Inc. | Immunogenic compositions against clostridioides (clostridium) difficile and methods thereof |
| CN112442472B (zh) * | 2020-11-30 | 2023-05-26 | 四川大学华西医院 | 抗艰难梭菌的重组乳酸乳球菌、活载体疫苗及其制备方法 |
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| US4879218A (en) | 1982-09-13 | 1989-11-07 | Virginia Tech Intellectual Properties, Inc. | Antibody for C.difficile |
| US4530833A (en) | 1982-09-13 | 1985-07-23 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4533630A (en) | 1982-09-13 | 1985-08-06 | Wilkins Tracy D | Toxins and antibodies of C. difficile |
| US4863852A (en) | 1985-07-03 | 1989-09-05 | Virginia Tech Intellectual Properties, Inc. | Method of detecting, isolating and purifying clostridium difficile toxin A and its receptors |
| GB8517071D0 (en) * | 1985-07-05 | 1985-08-14 | Hoffmann La Roche | Gram-positive expression control sequence |
| US5736139A (en) | 1989-10-31 | 1998-04-07 | Ochidian Pharmaceuticals, Inc. | Treatment of Clostridium difficile induced disease |
| US5098826A (en) | 1990-03-09 | 1992-03-24 | Virginia Tech Intellectual Properties, Inc. | Detection, isolation and purification of Clostridium difficile toxin A with toxin receptors |
| US7018809B1 (en) * | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
| NZ295998A (en) * | 1994-10-24 | 1999-10-28 | Ophidian Pharm Inc | Neutralizing antitoxins against clostridium difficile and clostidium botulinum toxins |
| US5919463A (en) | 1995-07-07 | 1999-07-06 | Oravax, Inc. | Clostridium difficle toxins as mucosal adjuvants |
| NZ312502A (en) * | 1995-07-07 | 1999-03-29 | Oravax Inc | Clostridium difficile toxins as mucosal adjuvants |
| JPH09323999A (ja) * | 1996-06-03 | 1997-12-16 | Unitika Ltd | 人工タンパク質ポリマー |
| EP1000155A1 (en) * | 1997-06-20 | 2000-05-17 | QUEEN MARY & WESTFIELD COLLEGE | Immunogenic fragments of toxin a of clostridium difficile |
| PL2753352T5 (pl) * | 2010-09-03 | 2022-10-17 | Valneva Austria Gmbh | Izolowany polipeptyd białek toksyny a i toksyny b z c. difficile i jego zastosowania |
-
2000
- 2000-04-10 JP JP2000611685A patent/JP2002542169A/ja active Pending
- 2000-04-10 EP EP00931926A patent/EP1169456B1/en not_active Expired - Lifetime
- 2000-04-10 WO PCT/US2000/009525 patent/WO2000061762A1/en not_active Ceased
- 2000-04-10 CA CA2365915A patent/CA2365915C/en not_active Expired - Fee Related
- 2000-04-10 EP EP12155470A patent/EP2502998A3/en not_active Withdrawn
- 2000-04-10 AU AU49732/00A patent/AU781175B2/en not_active Ceased
-
2009
- 2009-12-28 JP JP2009298925A patent/JP5566684B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU781175B2 (en) | 2005-05-12 |
| EP2502998A3 (en) | 2013-02-27 |
| CA2365915A1 (en) | 2000-10-19 |
| JP2010083898A (ja) | 2010-04-15 |
| JP2002542169A (ja) | 2002-12-10 |
| WO2000061762A1 (en) | 2000-10-19 |
| AU4973200A (en) | 2000-11-14 |
| EP1169456A1 (en) | 2002-01-09 |
| EP2502998A2 (en) | 2012-09-26 |
| JP5566684B2 (ja) | 2014-08-06 |
| EP1169456B1 (en) | 2012-07-11 |
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| MKLA | Lapsed |
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