CA2364245C - Sel double soluble de metaux des groupes ia et iia d'acide (-) hydroxycitrique - Google Patents

Sel double soluble de metaux des groupes ia et iia d'acide (-) hydroxycitrique Download PDF

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Publication number
CA2364245C
CA2364245C CA2364245A CA2364245A CA2364245C CA 2364245 C CA2364245 C CA 2364245C CA 2364245 A CA2364245 A CA 2364245A CA 2364245 A CA2364245 A CA 2364245A CA 2364245 C CA2364245 C CA 2364245C
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CA
Canada
Prior art keywords
hydroxycitric acid
group
weight
metal salt
iia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2364245A
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English (en)
Other versions
CA2364245A1 (fr
Inventor
Pillarisetti Venkata Subbarao
Karnam Balasubramanyam
Bhaskaran Chandrashekar
Candadai Seshadri Ramadoss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vittal Mallya Scientific Research Foundation
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Vittal Mallya Scientific Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vittal Mallya Scientific Research Foundation filed Critical Vittal Mallya Scientific Research Foundation
Publication of CA2364245A1 publication Critical patent/CA2364245A1/fr
Application granted granted Critical
Publication of CA2364245C publication Critical patent/CA2364245C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/48—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Child & Adolescent Psychology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un nouveau sel double soluble de métaux des groupes IA et IIA d'acide (-)hydroxycitrique représenté par les formules générales (I) et plus particulièrement (II). L'invention concerne également un procédé permettant de préparer le sel double soluble de métaux des groupes IA et IIA d'acide (-)hydroxycitrique représenté par la formule générale (I). Ce procédé consiste à préparer un concentré liquide d'acide (-)hydroxycitrique ou une lactone solide de ce dernier à partir d'un extrait de Garcinia, à neutraliser l'acide (-)hydroxycitrique libre présent dans ce concentré liquide/lactone solide d'acide (-)hydroxycitrique à l'aide d'hydroxydes métalliques du groupe IA, à déplacer partiellement les ions métalliques du groupe IA dans les solutions salines ci-dessus par l'adjonction de chlorures métalliques du groupe IIA afin de former un sel double soluble de métaux des groupes IA et IIA d'acide (-)hydroxycitrique, puis à précipiter ce sel double métallique. L'invention concerne en outre l'utilisation de ce sel double métallique soluble d'acide (-)hydroxycitrique dans des boissons et d'autres produits alimentaires.
CA2364245A 1999-02-18 1999-02-18 Sel double soluble de metaux des groupes ia et iia d'acide (-) hydroxycitrique Expired - Fee Related CA2364245C (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN1999/000004 WO2000048983A1 (fr) 1999-02-18 1999-02-18 Sel double soluble de metaux des groupes ia et iia d'acide (-) hydroxycitrique

Publications (2)

Publication Number Publication Date
CA2364245A1 CA2364245A1 (fr) 2000-08-24
CA2364245C true CA2364245C (fr) 2010-10-05

Family

ID=11076651

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2364245A Expired - Fee Related CA2364245C (fr) 1999-02-18 1999-02-18 Sel double soluble de metaux des groupes ia et iia d'acide (-) hydroxycitrique

Country Status (6)

Country Link
EP (1) EP1154978A1 (fr)
JP (1) JP2002542152A (fr)
AU (1) AU2851799A (fr)
CA (1) CA2364245C (fr)
IL (1) IL144827A0 (fr)
WO (1) WO2000048983A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1011660A1 (fr) 1997-07-14 2000-06-28 Inter-Health Nutraceuticals Incorporated Compositions d'acide hydroxycitrique, complements alimentaires et pharmaceutiques et produits alimentaires fabriques a partir de ces compositions, et procede d'utilisation de tels produits pour la reduction du poids corporel
US7119110B2 (en) 2001-10-05 2006-10-10 Interhealth Nutraceuticals Incorporated Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
US20030119913A1 (en) 2001-12-20 2003-06-26 Ohia Sunny E. Method for increasing serotonin levels in a person by administration of a composition incorporating (-)-hydroxycitric acid, and related compositions thereof
US6875891B2 (en) * 2003-05-12 2005-04-05 Laila Impex Process for preparing highly water soluble double salts of hydroxycitric acid particularly alkali and alkaline earth metal double salts
WO2005025544A1 (fr) * 2003-09-11 2005-03-24 Glykon Technologies Group, Llc Administration enterique d'acide (-)-hydroxycitrique
US20100152488A1 (en) * 2007-02-16 2010-06-17 Vittal Mallya Scientific Research Foundation High Purity (-) Hydroxycitric Acid Metal Salt Derivatives and Method of Preparation of the Same
JP2011079752A (ja) * 2009-10-05 2011-04-21 Kracie Home Products Ltd 膵リパーゼ阻害剤並びにそれを含有する飲食品組成物及び医薬品組成物
EP3509578B1 (fr) * 2016-09-08 2022-12-21 Glykon Technologies Group, LLC Composés d'acide hydroxycitrique bimétalliques monomères et leurs procédés de fabrication et utilisation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536630A (en) * 1968-05-21 1970-10-27 Us Agriculture Calcium sequestration in highly alkaline medium
US5536516A (en) * 1994-08-24 1996-07-16 Renaissance Herbs, Inc. Hydroxycitric acid concentrate and food products prepared therefrom
AU5736096A (en) * 1995-05-15 1996-11-29 Sabinsa Corporation A new process for the production of potassium hydroxy citric acid, and compositions containing the potassium hydroxy cit ric acid

Also Published As

Publication number Publication date
EP1154978A1 (fr) 2001-11-21
WO2000048983A1 (fr) 2000-08-24
CA2364245A1 (fr) 2000-08-24
IL144827A0 (en) 2002-06-30
JP2002542152A (ja) 2002-12-10
AU2851799A (en) 2000-09-04

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