CA2361584C - Anticonvulsant derivatives useful in treating autism - Google Patents
Anticonvulsant derivatives useful in treating autism Download PDFInfo
- Publication number
- CA2361584C CA2361584C CA002361584A CA2361584A CA2361584C CA 2361584 C CA2361584 C CA 2361584C CA 002361584 A CA002361584 A CA 002361584A CA 2361584 A CA2361584 A CA 2361584A CA 2361584 C CA2361584 C CA 2361584C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- formula
- effective amount
- therapeutically effective
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000020706 Autistic disease Diseases 0.000 title claims abstract description 19
- 206010003805 Autism Diseases 0.000 title claims abstract description 18
- 239000001961 anticonvulsive agent Substances 0.000 title abstract description 6
- 230000001773 anti-convulsant effect Effects 0.000 title abstract description 4
- 229960003965 antiepileptics Drugs 0.000 title abstract description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 29
- 150000001875 compounds Chemical class 0.000 claims description 26
- 239000001257 hydrogen Substances 0.000 claims description 15
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- -1 methylenedioxy group Chemical group 0.000 claims description 11
- KJADKKWYZYXHBB-XBWDGYHZSA-N Topiramic acid Chemical compound C1O[C@@]2(COS(N)(=O)=O)OC(C)(C)O[C@H]2[C@@H]2OC(C)(C)O[C@@H]21 KJADKKWYZYXHBB-XBWDGYHZSA-N 0.000 claims description 9
- 229960004394 topiramate Drugs 0.000 claims description 9
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 7
- 239000001301 oxygen Substances 0.000 claims description 7
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 5
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
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- 239000003826 tablet Substances 0.000 description 2
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- WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
- 208000036640 Asperger disease Diseases 0.000 description 1
- 201000006062 Asperger syndrome Diseases 0.000 description 1
- 206010005885 Blunted affect Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
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- 239000002202 Polyethylene glycol Substances 0.000 description 1
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- 241000700159 Rattus Species 0.000 description 1
- 208000006289 Rett Syndrome Diseases 0.000 description 1
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- 150000001298 alcohols Chemical class 0.000 description 1
- 125000002009 alkene group Chemical group 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
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- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 201000007201 aphasia Diseases 0.000 description 1
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- 150000001540 azides Chemical class 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- UWTDFICHZKXYAC-UHFFFAOYSA-N boron;oxolane Chemical compound [B].C1CCOC1 UWTDFICHZKXYAC-UHFFFAOYSA-N 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
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- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
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- YUMNNMSNSLHINV-UHFFFAOYSA-N chloro sulfamate Chemical compound NS(=O)(=O)OCl YUMNNMSNSLHINV-UHFFFAOYSA-N 0.000 description 1
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- 208000013500 continuous spikes and waves during sleep Diseases 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
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- 229910052700 potassium Inorganic materials 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
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- 150000008163 sugars Chemical class 0.000 description 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-M sulfamate Chemical compound NS([O-])(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-M 0.000 description 1
- YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 235000013759 synthetic iron oxide Nutrition 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
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- 235000005074 zinc chloride Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11910499P | 1999-02-08 | 1999-02-08 | |
| US60/119,104 | 1999-02-08 | ||
| PCT/US2000/001127 WO2000045812A1 (en) | 1999-02-08 | 2000-01-18 | Anticonvulsant derivatives useful in treating autism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2361584A1 CA2361584A1 (en) | 2000-08-10 |
| CA2361584C true CA2361584C (en) | 2005-06-14 |
Family
ID=22382571
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002361584A Expired - Fee Related CA2361584C (en) | 1999-02-08 | 2000-01-18 | Anticonvulsant derivatives useful in treating autism |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6552000B2 (enExample) |
| EP (1) | EP1152756B1 (enExample) |
| JP (1) | JP2002536328A (enExample) |
| AR (1) | AR029334A1 (enExample) |
| AT (1) | ATE299371T1 (enExample) |
| AU (1) | AU763601B2 (enExample) |
| CA (1) | CA2361584C (enExample) |
| DE (1) | DE60021252T2 (enExample) |
| DK (1) | DK1152756T3 (enExample) |
| ES (1) | ES2244411T3 (enExample) |
| MX (1) | MXPA01008038A (enExample) |
| PT (1) | PT1152756E (enExample) |
| TR (1) | TR200103125T2 (enExample) |
| WO (1) | WO2000045812A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060020037A1 (en) * | 2004-07-22 | 2006-01-26 | Allergan, Inc. | Tazarotenic acid and esters thereof for treating autism |
| US9095713B2 (en) * | 2004-12-21 | 2015-08-04 | Allison M. Foster | Methods and systems for treating autism by decreasing neural activity within the brain |
| US20070038264A1 (en) * | 2004-12-21 | 2007-02-15 | Jaax Kristen N | Methods and systems for treating autism |
| US9327069B2 (en) * | 2004-12-21 | 2016-05-03 | Boston Scientific Neuromodulation Corporation | Methods and systems for treating a medical condition by promoting neural remodeling within the brain |
| US20070034214A1 (en) * | 2005-08-12 | 2007-02-15 | Dochniak Michael J | Method to affect the development of autism spectrum disorders |
| US20090076128A1 (en) * | 2007-09-15 | 2009-03-19 | Protia Llc | Deuterium-enriched topiramate |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| AU2015298618A1 (en) * | 2014-05-30 | 2016-12-08 | The Children's Hospital Of Philadelphia | Genetic alterations associated with autism and autistic phenotype and methods of diagnosing and treating autism |
| US11219617B2 (en) | 2014-05-30 | 2022-01-11 | The Children's Hospital Of Philadelphia | Methods of diagnosing and treating autism |
| WO2018057596A1 (en) * | 2016-09-21 | 2018-03-29 | JC Pharma, Inc. | Method and composition for acute treatment of seizures |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4513006A (en) * | 1983-09-26 | 1985-04-23 | Mcneil Lab., Inc. | Anticonvulsant sulfamate derivatives |
| US5753693A (en) | 1996-06-28 | 1998-05-19 | Ortho Pharmaceutical Corporation | Anticonvulsant derivatives useful in treating manic-depressive bipolar disorder |
| US6020310A (en) * | 1997-05-19 | 2000-02-01 | Repligen Corporation | Method for assisting in differential diagnosis and treatment of autistic syndromes |
-
2000
- 2000-01-18 WO PCT/US2000/001127 patent/WO2000045812A1/en not_active Ceased
- 2000-01-18 DE DE60021252T patent/DE60021252T2/de not_active Expired - Fee Related
- 2000-01-18 CA CA002361584A patent/CA2361584C/en not_active Expired - Fee Related
- 2000-01-18 AU AU26156/00A patent/AU763601B2/en not_active Ceased
- 2000-01-18 AT AT00904390T patent/ATE299371T1/de not_active IP Right Cessation
- 2000-01-18 MX MXPA01008038A patent/MXPA01008038A/es active IP Right Grant
- 2000-01-18 DK DK00904390T patent/DK1152756T3/da active
- 2000-01-18 JP JP2000596932A patent/JP2002536328A/ja not_active Withdrawn
- 2000-01-18 EP EP00904390A patent/EP1152756B1/en not_active Expired - Lifetime
- 2000-01-18 TR TR2001/03125T patent/TR200103125T2/xx unknown
- 2000-01-18 PT PT00904390T patent/PT1152756E/pt unknown
- 2000-01-18 US US09/484,522 patent/US6552000B2/en not_active Expired - Fee Related
- 2000-01-18 ES ES00904390T patent/ES2244411T3/es not_active Expired - Lifetime
- 2000-02-07 AR ARP000100525A patent/AR029334A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AU763601B2 (en) | 2003-07-31 |
| WO2000045812A1 (en) | 2000-08-10 |
| DK1152756T3 (da) | 2005-10-10 |
| US6552000B2 (en) | 2003-04-22 |
| AU2615600A (en) | 2000-08-25 |
| US20020035068A1 (en) | 2002-03-21 |
| JP2002536328A (ja) | 2002-10-29 |
| PT1152756E (pt) | 2005-09-30 |
| EP1152756B1 (en) | 2005-07-13 |
| CA2361584A1 (en) | 2000-08-10 |
| EP1152756A1 (en) | 2001-11-14 |
| ATE299371T1 (de) | 2005-07-15 |
| TR200103125T2 (tr) | 2002-04-22 |
| ES2244411T3 (es) | 2005-12-16 |
| AR029334A1 (es) | 2003-06-25 |
| MXPA01008038A (es) | 2002-04-24 |
| DE60021252D1 (de) | 2005-08-18 |
| DE60021252T2 (de) | 2006-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |