CA2361191A1 - Gene repair involving the induction of double-stranded dna cleavage at a chromosomal target site - Google Patents
Gene repair involving the induction of double-stranded dna cleavage at a chromosomal target site Download PDFInfo
- Publication number
- CA2361191A1 CA2361191A1 CA002361191A CA2361191A CA2361191A1 CA 2361191 A1 CA2361191 A1 CA 2361191A1 CA 002361191 A CA002361191 A CA 002361191A CA 2361191 A CA2361191 A CA 2361191A CA 2361191 A1 CA2361191 A1 CA 2361191A1
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- dna
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- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C07K2319/00—Fusion polypeptide
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11866999P | 1999-02-03 | 1999-02-03 | |
| US60/118,669 | 1999-02-03 | ||
| PCT/US2000/003014 WO2000046386A2 (en) | 1999-02-03 | 2000-02-03 | Gene repair involving the induction of double-stranded dna cleavage at a chromosomal target site |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2361191A1 true CA2361191A1 (en) | 2000-08-10 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002361191A Abandoned CA2361191A1 (en) | 1999-02-03 | 2000-02-03 | Gene repair involving the induction of double-stranded dna cleavage at a chromosomal target site |
Country Status (6)
| Country | Link |
|---|---|
| US (7) | US20020107214A1 (enExample) |
| EP (1) | EP1147209A2 (enExample) |
| JP (1) | JP2002535995A (enExample) |
| AU (1) | AU2982900A (enExample) |
| CA (1) | CA2361191A1 (enExample) |
| WO (1) | WO2000046386A2 (enExample) |
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| JPH0777556B2 (ja) * | 1990-08-21 | 1995-08-23 | 理化学研究所 | 部位特異的エンドヌクレアーゼＳｃｅＩの小サブユニットの遺伝子 |
| US5792640A (en) | 1992-04-03 | 1998-08-11 | The Johns Hopkins University | General method to clone hybrid restriction endonucleases using lig gene |
| US5436150A (en) * | 1992-04-03 | 1995-07-25 | The Johns Hopkins University | Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease |
| US5474896A (en) * | 1992-05-05 | 1995-12-12 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| US5792632A (en) * | 1992-05-05 | 1998-08-11 | Institut Pasteur | Nucleotide sequence encoding the enzyme I-SceI and the uses thereof |
| ATE178654T1 (de) * | 1993-12-20 | 1999-04-15 | Akzo Nobel Nv | Impstoff zum schutze von pferden gegen pferdeherpesvirus-infektionen |
| US5830729A (en) * | 1996-04-18 | 1998-11-03 | Institut Pasteur | I Sce I-induced gene replacement and gene conversion in embryonic stem cells |
| US6534261B1 (en) | 1999-01-12 | 2003-03-18 | Sangamo Biosciences, Inc. | Regulation of endogenous gene expression in cells using zinc finger proteins |
| CA2360878A1 (en) * | 1999-02-03 | 2000-08-10 | The Children's Medical Center Corporation | Gene repair involving excision of targeting dna |
| WO2000046386A2 (en) * | 1999-02-03 | 2000-08-10 | The Children's Medical Center Corporation | Gene repair involving the induction of double-stranded dna cleavage at a chromosomal target site |
| EP2180058A1 (en) * | 2008-10-23 | 2010-04-28 | Cellectis | Meganuclease recombination system |
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|---|---|
| US20100111924A1 (en) | 2010-05-06 |
| US8921332B2 (en) | 2014-12-30 |
| EP1147209A2 (en) | 2001-10-24 |
| US20120230971A1 (en) | 2012-09-13 |
| US20020107214A1 (en) | 2002-08-08 |
| US20040019002A1 (en) | 2004-01-29 |
| AU2982900A (en) | 2000-08-25 |
| US20170037434A1 (en) | 2017-02-09 |
| WO2000046386A2 (en) | 2000-08-10 |
| WO2000046386A3 (en) | 2000-12-14 |
| JP2002535995A (ja) | 2002-10-29 |
| US9458439B2 (en) | 2016-10-04 |
| US7629326B2 (en) | 2009-12-08 |
| WO2000046386A9 (en) | 2001-09-27 |
| US20150259655A1 (en) | 2015-09-17 |
| US20070141038A1 (en) | 2007-06-21 |
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