CA2361115A1 - Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs - Google Patents

Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs Download PDF

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Publication number
CA2361115A1
CA2361115A1 CA002361115A CA2361115A CA2361115A1 CA 2361115 A1 CA2361115 A1 CA 2361115A1 CA 002361115 A CA002361115 A CA 002361115A CA 2361115 A CA2361115 A CA 2361115A CA 2361115 A1 CA2361115 A1 CA 2361115A1
Authority
CA
Canada
Prior art keywords
complex
cyclam
derivative
group
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002361115A
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English (en)
Inventor
J. Donald Chapman
Richard F. Schneider
Edward L. Engelhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fox Chase Cancer Center
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2361115A1 publication Critical patent/CA2361115A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Du 1,4,8,11-tétraazaclyclotétradécane qui est chimiquement lié à un ou plusieurs groupes nitroimidazole dont le nombre peut varier entre un et quatre constitue un agent de radiodiagnostic efficace permettant de déterminer l'hypoxie tissulaire et la radiorésistance de tissus tumoraux.
CA002361115A 1999-01-26 2000-01-26 Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs Abandoned CA2361115A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11725399P 1999-01-26 1999-01-26
US60/117,253 1999-01-26
PCT/US2000/001754 WO2000043004A1 (fr) 1999-01-26 2000-01-26 Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs

Publications (1)

Publication Number Publication Date
CA2361115A1 true CA2361115A1 (fr) 2000-07-27

Family

ID=22371814

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002361115A Abandoned CA2361115A1 (fr) 1999-01-26 2000-01-26 Derives 1,4,8,11-tetraazacyclotetradecane utiles en tant qu'agents de radiodiagnostic et utilisation de ces derniers dans la determination de l'hypoxie et de la radioresistance des tumeurs

Country Status (3)

Country Link
EP (1) EP1148878A4 (fr)
CA (1) CA2361115A1 (fr)
WO (1) WO2000043004A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9408928B2 (en) 2007-03-27 2016-08-09 Radiomedix, Inc. Compositions for targeted imaging and therapy
US9550001B2 (en) 2011-06-20 2017-01-24 Radiomedix Inc. Compositions, methods of synthesis and use of carbohydrate targeted agents

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002026748A2 (fr) 2000-09-25 2002-04-04 The Procter & Gamble Company Complexes de metaux a utiliser dans des applications medicales et therapeutiques
WO2005087275A2 (fr) * 2004-03-11 2005-09-22 Board Of Regents, The University Of Texas System Agents d'imagerie tep radiomarques metalliques
US7842278B2 (en) * 2006-10-27 2010-11-30 Natural Pharmacia International, Inc. Hypoxia-selective, weakly basic 2-nitroimidazole delivery agents and methods of use thereof
CN101486707B (zh) * 2009-02-27 2012-08-29 北京师范大学 亲乏氧肿瘤的硝基咪唑类配合物及其制备方法和应用
CN101486708B (zh) * 2009-02-27 2012-08-29 北京师范大学 一类锝-99m标记的肿瘤乏氧显像剂及其制备方法和应用
CN103189057B (zh) * 2010-08-26 2015-02-18 崔坤元 大环脂类化合物及其应用
WO2019056098A1 (fr) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta Composés activés par bioréduction, leurs promédicaments, produits radiopharmaceutiques, les compositions et leurs applications dans la gestion théranostique multimodale de l'hypoxie, dont le cancer
CA3076256A1 (fr) * 2017-09-19 2019-03-28 The Governors Of The University Of Alberta Marqueurs, conjugues, compositions et procedes d'imagerie, de cartographie et de therapie de l'hypoxie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2654102B1 (fr) * 1989-11-09 1992-01-10 Air Liquide Procede de synthese de derives polyazotes cycliques.
JP2885944B2 (ja) * 1991-02-01 1999-04-26 富士写真フイルム株式会社 複素環基を有するアミン化合物
US5708022A (en) * 1994-10-28 1998-01-13 Procept, Inc. Method for inhibiting immune response
GB9511357D0 (en) * 1995-06-06 1995-08-02 Johnson Matthey Plc Improved antiviral compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9408928B2 (en) 2007-03-27 2016-08-09 Radiomedix, Inc. Compositions for targeted imaging and therapy
US9550001B2 (en) 2011-06-20 2017-01-24 Radiomedix Inc. Compositions, methods of synthesis and use of carbohydrate targeted agents

Also Published As

Publication number Publication date
WO2000043004A1 (fr) 2000-07-27
EP1148878A4 (fr) 2003-04-02
EP1148878A1 (fr) 2001-10-31

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Legal Events

Date Code Title Description
FZDE Discontinued