CA2361034A1 - Proteines associees a la regeneration neuronale et leur utilisation - Google Patents

Proteines associees a la regeneration neuronale et leur utilisation Download PDF

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Publication number
CA2361034A1
CA2361034A1 CA002361034A CA2361034A CA2361034A1 CA 2361034 A1 CA2361034 A1 CA 2361034A1 CA 002361034 A CA002361034 A CA 002361034A CA 2361034 A CA2361034 A CA 2361034A CA 2361034 A1 CA2361034 A1 CA 2361034A1
Authority
CA
Canada
Prior art keywords
ser
hnprap
leu
ala
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002361034A
Other languages
English (en)
Inventor
Peter H. St. George-Hyslop
Paul E. Fraser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toronto
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2361034A1 publication Critical patent/CA2361034A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un procédé de stimulation de la croissance nerveuse, notamment de régénération nerveuse, consistant à mettre en contact des cellules nerveuses avec la protéine humaine neuronale Armadillo (hNPRAP), apparentée à la Plakophiline. Dans un mode de réalisation spécifique, la protéine hNPRAP provoque le développement de nombreuses extensions cellulaires, longiformes, similaires à un bourgeonnement axonal observé lors de la régénération neuronale et de la formation de synapses. L'invention concerne encore des compositions pharmaceutiques comprenant la protéine hNPRAP, ou bien un vecteur de thérapie génique exprimant la protéine hNPRAP, de même que des procédés d'identification de substances modulant l'expression de la protéine hNPRAP.
CA002361034A 1999-02-12 2000-02-11 Proteines associees a la regeneration neuronale et leur utilisation Abandoned CA2361034A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11983599P 1999-02-12 1999-02-12
US60/119,835 1999-02-12
PCT/CA2000/000126 WO2000047615A2 (fr) 1999-02-12 2000-02-11 Proteines associees a la regeneration neuronale et leur utilisation

Publications (1)

Publication Number Publication Date
CA2361034A1 true CA2361034A1 (fr) 2000-08-17

Family

ID=22386671

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002361034A Abandoned CA2361034A1 (fr) 1999-02-12 2000-02-11 Proteines associees a la regeneration neuronale et leur utilisation

Country Status (6)

Country Link
EP (1) EP1165604A2 (fr)
JP (1) JP2002541060A (fr)
AU (1) AU2652600A (fr)
CA (1) CA2361034A1 (fr)
MX (1) MXPA01007944A (fr)
WO (1) WO2000047615A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021041324A2 (fr) * 2019-08-23 2021-03-04 Duke University Compositions et procédés pour le traitement de douleurs et de démangeaisons pathologiques

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0876483A1 (fr) * 1996-01-26 1998-11-11 HSC Research and Development Limited Partnership Acides nucleiques et proteines lies a la maladie d'alzheimer et leurs utilisations
JP2001510991A (ja) * 1996-12-02 2001-08-07 ザ ブリガム アンド ウイメンズ ホスピタル，インク． Ａｌａｒｍ関連ペプチドおよび核酸ならびにそれらを用いた診断

Also Published As

Publication number Publication date
AU2652600A (en) 2000-08-29
EP1165604A2 (fr) 2002-01-02
WO2000047615A2 (fr) 2000-08-17
WO2000047615A3 (fr) 2000-11-30
MXPA01007944A (es) 2003-09-10
JP2002541060A (ja) 2002-12-03

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FZDE Dead