CA2359416A1 - 6-arylphenanthridines with pde-iv inhibiting activity - Google Patents
6-arylphenanthridines with pde-iv inhibiting activity Download PDFInfo
- Publication number
- CA2359416A1 CA2359416A1 CA002359416A CA2359416A CA2359416A1 CA 2359416 A1 CA2359416 A1 CA 2359416A1 CA 002359416 A CA002359416 A CA 002359416A CA 2359416 A CA2359416 A CA 2359416A CA 2359416 A1 CA2359416 A1 CA 2359416A1
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- Canada
- Prior art keywords
- hydrogen
- alkoxy
- alkyl
- formula
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100705 | 1999-01-15 | ||
| EP99100705.5 | 1999-01-15 | ||
| PCT/EP2000/000152 WO2000042019A1 (en) | 1999-01-15 | 2000-01-12 | 6-arylphenanthridines with pde-iv inhibiting activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2359416A1 true CA2359416A1 (en) | 2000-07-20 |
Family
ID=8237353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002359416A Abandoned CA2359416A1 (en) | 1999-01-15 | 2000-01-12 | 6-arylphenanthridines with pde-iv inhibiting activity |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6479505B1 (enExample) |
| EP (1) | EP1147088B1 (enExample) |
| JP (1) | JP2002534507A (enExample) |
| AT (1) | ATE315029T1 (enExample) |
| AU (1) | AU2289400A (enExample) |
| CA (1) | CA2359416A1 (enExample) |
| CY (1) | CY1105427T1 (enExample) |
| DE (1) | DE60025327T2 (enExample) |
| DK (1) | DK1147088T3 (enExample) |
| ES (1) | ES2255483T3 (enExample) |
| PT (1) | PT1147088E (enExample) |
| SI (1) | SI1147088T1 (enExample) |
| WO (1) | WO2000042019A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200101938T2 (tr) * | 1999-01-15 | 2001-12-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pde-ıv inhibe edici aktivitesi olan fenilfenantridinler. |
| ES2236288T3 (es) | 2000-07-14 | 2005-07-16 | Altana Pharma Ag | 6-heteroarilfenantridinas. |
| JP2004532228A (ja) * | 2001-04-18 | 2004-10-21 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Ｐｄｅ阻害作用をもつアリールインデノピリジン |
| US6958328B2 (en) | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
| US6903109B2 (en) | 2001-04-18 | 2005-06-07 | Ortho-Muniel Pharmaceutical, Inc. | Arylindenopyridines and related therapeutic and prophylactic methods |
| US20040127510A1 (en) | 2002-04-16 | 2004-07-01 | Heintzelman Geoffrey R. | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods |
| WO2004018431A2 (en) * | 2002-08-17 | 2004-03-04 | Altana Pharma Ag | Novel phenanthridines |
| WO2004019945A1 (en) | 2002-08-29 | 2004-03-11 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| CN100556904C (zh) | 2004-01-23 | 2009-11-04 | 三共农业株式会社 | 3-(二氢(四氢)异喹啉-1-基)喹啉化合物 |
| WO2005077906A1 (en) | 2004-02-18 | 2005-08-25 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
| AU2005219576B2 (en) * | 2004-03-03 | 2011-06-30 | Takeda Gmbh | Novel hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
| WO2006092417A1 (en) * | 2005-03-02 | 2006-09-08 | Nycomed Gmbh | 6 -heteroaryl-1, 2, 3,4,4a, 1ob-hexahydro-phenanthridines as pde-4 inhibitors for the treatment of inflammatory disorders |
| NZ589278A (en) | 2005-03-02 | 2012-04-27 | Nycomed Gmbh | Selected salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives |
| JP5164567B2 (ja) * | 2005-05-17 | 2013-03-21 | 大鵬薬品工業株式会社 | 慢性副鼻腔炎の重症度および再発性の検査方法 |
| NO340563B1 (no) * | 2016-09-05 | 2017-05-15 | Takeda Gmbh | Nye salter av 6-heterocyklylsubstituerte heksahydrofenantridinderivater |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE233735T1 (de) | 1996-01-31 | 2003-03-15 | Altana Pharma Ag | Neue phenanthridine |
| PT889886E (pt) * | 1996-03-26 | 2003-02-28 | Altana Pharma Ag | Novas fenantridinas substituidas na posicao 6 |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| WO1999005113A1 (en) | 1997-07-25 | 1999-02-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituted 6-phenylphenanthridines |
| ATE260899T1 (de) | 1997-07-25 | 2004-03-15 | Altana Pharma Ag | Neue tetrazolderivate |
-
2000
- 2000-01-12 JP JP2000593587A patent/JP2002534507A/ja not_active Withdrawn
- 2000-01-12 EP EP00901530A patent/EP1147088B1/en not_active Expired - Lifetime
- 2000-01-12 US US09/889,143 patent/US6479505B1/en not_active Expired - Fee Related
- 2000-01-12 AT AT00901530T patent/ATE315029T1/de not_active IP Right Cessation
- 2000-01-12 ES ES00901530T patent/ES2255483T3/es not_active Expired - Lifetime
- 2000-01-12 CA CA002359416A patent/CA2359416A1/en not_active Abandoned
- 2000-01-12 WO PCT/EP2000/000152 patent/WO2000042019A1/en not_active Ceased
- 2000-01-12 AU AU22894/00A patent/AU2289400A/en not_active Abandoned
- 2000-01-12 SI SI200030823T patent/SI1147088T1/sl unknown
- 2000-01-12 DK DK00901530T patent/DK1147088T3/da active
- 2000-01-12 PT PT00901530T patent/PT1147088E/pt unknown
- 2000-01-12 DE DE60025327T patent/DE60025327T2/de not_active Expired - Fee Related
-
2006
- 2006-03-13 CY CY20061100351T patent/CY1105427T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2002534507A (ja) | 2002-10-15 |
| WO2000042019A1 (en) | 2000-07-20 |
| SI1147088T1 (sl) | 2006-06-30 |
| EP1147088A1 (en) | 2001-10-24 |
| EP1147088B1 (en) | 2006-01-04 |
| CY1105427T1 (el) | 2010-04-28 |
| PT1147088E (pt) | 2006-05-31 |
| ATE315029T1 (de) | 2006-02-15 |
| ES2255483T3 (es) | 2006-07-01 |
| DE60025327D1 (de) | 2006-03-30 |
| AU2289400A (en) | 2000-08-01 |
| DK1147088T3 (da) | 2006-05-15 |
| DE60025327T2 (de) | 2006-08-24 |
| US6479505B1 (en) | 2002-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |