CA2353578A1 - Application de contrainte de cisaillement par ecoulement a des cellules de muscle lisse pour la production d'implants - Google Patents
Application de contrainte de cisaillement par ecoulement a des cellules de muscle lisse pour la production d'implants Download PDFInfo
- Publication number
- CA2353578A1 CA2353578A1 CA002353578A CA2353578A CA2353578A1 CA 2353578 A1 CA2353578 A1 CA 2353578A1 CA 002353578 A CA002353578 A CA 002353578A CA 2353578 A CA2353578 A CA 2353578A CA 2353578 A1 CA2353578 A1 CA 2353578A1
- Authority
- CA
- Canada
- Prior art keywords
- cells
- shear flow
- smooth muscle
- scaffold
- flow stress
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0691—Vascular smooth muscle cells; 3D culture thereof, e.g. models of blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/52—Fibronectin; Laminin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
La présente invention se rapporte à des procédés de culture de cellules de muscle lisse destinées à la production de greffons tissulaires ou d'autres structures de remplacement implantables. L'invention concerne plus spécifiquement l'application de contrainte de cisaillement par écoulement appliquée à des cellules de muscle lisse en culture, dans laquelle les cellules prennent un alignement perpendiculaire à la direction de l'écoulement, alignement qui est proche de l'orientation des cellules in vivo. Les cultures résultantes et les procédés sont utiles pour la production de greffons vasculaires améliorés, de vaisseaux et d'autres structures implantables destinées à la correction de défauts ou de tissus anormaux du corps.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11176098P | 1998-12-11 | 1998-12-11 | |
US60/111,760 | 1998-12-11 | ||
PCT/US1999/029257 WO2000034442A2 (fr) | 1998-12-11 | 1999-12-10 | Application de contrainte de cisaillement par ecoulement a des cellules de muscle lisse pour la production d'implants |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2353578A1 true CA2353578A1 (fr) | 2000-06-15 |
Family
ID=22340317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002353578A Abandoned CA2353578A1 (fr) | 1998-12-11 | 1999-12-10 | Application de contrainte de cisaillement par ecoulement a des cellules de muscle lisse pour la production d'implants |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1144596A2 (fr) |
JP (1) | JP2002531118A (fr) |
AU (1) | AU2171900A (fr) |
CA (1) | CA2353578A1 (fr) |
IL (1) | IL143564A0 (fr) |
WO (1) | WO2000034442A2 (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1782849A3 (fr) * | 1999-04-12 | 2007-05-23 | Theregen, Inc. | Tissu stromal tridimensionnel |
US20030007954A1 (en) | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
DE10061704A1 (de) * | 2000-12-12 | 2002-06-20 | Hans Joerg Bauer | Verfahren und Vorrichtung zur Herstellung von biologischem Gewebe in einer Wachstumskammer |
JP2002315566A (ja) * | 2001-04-24 | 2002-10-29 | Takagi Ind Co Ltd | 細胞・組織培養装置 |
US20050079604A1 (en) * | 2001-11-28 | 2005-04-14 | Lucie Germain | Method for improving functionality of tissue constructs |
US20050019488A1 (en) * | 2001-11-30 | 2005-01-27 | Cambridge Polymer Group, Inc., Boston, Ma | Layered aligned polymer structures and methods of making same |
US7048963B2 (en) | 2001-11-30 | 2006-05-23 | Cambridge Polymers Group, Inc. | Layered aligned polymer structures and methods of making same |
US7387645B2 (en) * | 2003-04-25 | 2008-06-17 | Medtronic Vascular, Inc. | Cellular therapy to heal vascular tissue |
WO2005010172A2 (fr) * | 2003-07-16 | 2005-02-03 | Boston Scientific Limited | Structures d'echafaudage alignees pour regeneration myocardique accrue |
WO2005039396A2 (fr) * | 2003-10-22 | 2005-05-06 | Medtrain Technologies, Llc | Systeme d'imagerie analytique de constructions tissulaires artificielles et procede permettant d'obtenir et d'analyser des constructions tissulaires artificielles |
WO2006113382A2 (fr) | 2005-04-15 | 2006-10-26 | Wake Forest University Health Sciences | Systeme de bioreacteur et procede destine a ameliorer la fonctionnalite du muscle cultive in vitro |
JP4919296B2 (ja) * | 2005-12-26 | 2012-04-18 | 国立大学法人大阪大学 | 生体形状を含んだ三次元組織の培養方法 |
JP4989108B2 (ja) | 2006-05-25 | 2012-08-01 | Jnc株式会社 | 血管平滑筋細胞の培養方法、培養器材および培養によって得られる医療用材料 |
US8058057B2 (en) | 2008-05-30 | 2011-11-15 | Corning Incorporated | Cell culture apparatus and method |
JP2012523238A (ja) | 2009-04-09 | 2012-10-04 | ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティ・オブ・アリゾナ | 三次元繊維芽細胞構築物の細胞播種および共培養 |
US8507263B2 (en) | 2009-08-07 | 2013-08-13 | Maria Adelaide Asnaghi | Rotating bioreactor |
WO2012021814A2 (fr) | 2010-08-13 | 2012-02-16 | Wake Forest University Health Sciences | Méthodes de préparation in vitro d'un substitut de réparation musculaire destiné à être implanté in vivo |
WO2014174899A1 (fr) * | 2013-04-23 | 2014-10-30 | 国立大学法人徳島大学 | Cellule compressée ou tissu compressé en tant que modèle cellulaire d'affection pathologique et procédé de fabrication associé |
AU2018283372A1 (en) | 2017-06-16 | 2020-02-06 | Avery Therapeutics, Inc. | Three dimensional tissue compositions and methods of use |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2195095A (en) * | 1994-03-24 | 1995-10-09 | University Of Washington | Devices and methods for implanting transduced cells |
US5792603A (en) * | 1995-04-27 | 1998-08-11 | Advanced Tissue Sciences, Inc. | Apparatus and method for sterilizing, seeding, culturing, storing, shipping and testing tissue, synthetic or native, vascular grafts |
-
1999
- 1999-12-10 CA CA002353578A patent/CA2353578A1/fr not_active Abandoned
- 1999-12-10 JP JP2000586876A patent/JP2002531118A/ja active Pending
- 1999-12-10 IL IL14356499A patent/IL143564A0/xx unknown
- 1999-12-10 WO PCT/US1999/029257 patent/WO2000034442A2/fr not_active Application Discontinuation
- 1999-12-10 EP EP99966089A patent/EP1144596A2/fr not_active Withdrawn
- 1999-12-10 AU AU21719/00A patent/AU2171900A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2002531118A (ja) | 2002-09-24 |
WO2000034442A2 (fr) | 2000-06-15 |
WO2000034442A3 (fr) | 2001-11-01 |
IL143564A0 (en) | 2002-04-21 |
AU2171900A (en) | 2000-06-26 |
EP1144596A2 (fr) | 2001-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20031210 |