CA2352571C - Biocapteur in vivo et son procede d'utilisation - Google Patents

Biocapteur in vivo et son procede d'utilisation Download PDF

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Publication number
CA2352571C
CA2352571C CA002352571A CA2352571A CA2352571C CA 2352571 C CA2352571 C CA 2352571C CA 002352571 A CA002352571 A CA 002352571A CA 2352571 A CA2352571 A CA 2352571A CA 2352571 C CA2352571 C CA 2352571C
Authority
CA
Canada
Prior art keywords
implantable
bioelectronic device
cells
bioreporter
monolithic bioelectronic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002352571A
Other languages
English (en)
Other versions
CA2352571A1 (fr
Inventor
Gary S. Sayler
Michael L. Simpson
Bruce M. Applegate
Steven A. Ripp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UT Battelle LLC
University of Tennessee Research Foundation
Original Assignee
UT Battelle LLC
University of Tennessee Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UT Battelle LLC, University of Tennessee Research Foundation filed Critical UT Battelle LLC
Publication of CA2352571A1 publication Critical patent/CA2352571A1/fr
Application granted granted Critical
Publication of CA2352571C publication Critical patent/CA2352571C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Analytical Chemistry (AREA)
  • Surgery (AREA)
  • Emergency Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)

Abstract

Cette invention concerne des dispositifs à circuit intégré avec bioreporter bioluminescent capables de détecter certains analysats dans des liquides, une fois implantés dans l'organisme d'un animal. Le dispositif comprend un bioreporter mis au point par génie génétique. Ce bioreporter renferme un segment d'acides nucléiques comprenant un élément de réponse cis-activant qui répond à la subsistance retenue, laquelle substance est fonctionnellement liée à un gène codant pour le polypeptide reporter bioluminescent. Selon des modes de réalisation préférés, l'analysat cible est le glucose, le glicagon et l'insuline. L'exposition du bioreporter à la substance cible conduit l'élément de réponse à assurer une régulation positive de la séquence d'acides nucléiques codant pour le polypeptide reporter, lequel produit une réponse bioluminescente qui est détectée et quantifiée. Selon des modes de réalisation types, le dispositif bioreporter est encapsulé sur un circuit intégré qui est capable de détecter la lumière émise, de traiter le signal correspondant et de communiquer les résultats à distance. L'invention traite également de systèmes d'administration de médicaments qui sont commandés directement ou indirectement par le dispositif de détection et qui permettent d'administrer des médicaments tels que de l'insuline à un animal en réponse à la quantité d'analysat cible présente dans les liquides organiques.
CA002352571A 1998-12-02 1999-12-02 Biocapteur in vivo et son procede d'utilisation Expired - Fee Related CA2352571C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11068498P 1998-12-02 1998-12-02
US60/110,684 1998-12-02
PCT/US1999/028733 WO2000033065A1 (fr) 1998-12-02 1999-12-02 Biocapteur in vivo et son procede d'utilisation

Publications (2)

Publication Number Publication Date
CA2352571A1 CA2352571A1 (fr) 2000-06-08
CA2352571C true CA2352571C (fr) 2007-02-27

Family

ID=22334332

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002352571A Expired - Fee Related CA2352571C (fr) 1998-12-02 1999-12-02 Biocapteur in vivo et son procede d'utilisation

Country Status (7)

Country Link
EP (1) EP1135677A1 (fr)
JP (1) JP2002531194A (fr)
KR (1) KR20010102951A (fr)
AU (1) AU762948B2 (fr)
CA (1) CA2352571C (fr)
HK (1) HK1040767A1 (fr)
WO (1) WO2000033065A1 (fr)

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Also Published As

Publication number Publication date
JP2002531194A (ja) 2002-09-24
WO2000033065A1 (fr) 2000-06-08
AU762948B2 (en) 2003-07-10
CA2352571A1 (fr) 2000-06-08
HK1040767A1 (zh) 2002-06-21
KR20010102951A (ko) 2001-11-17
EP1135677A1 (fr) 2001-09-26
AU2040800A (en) 2000-06-19

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